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Heyu Ni, … , Richard O. Hynes, Denisa D. Wagner
Published August 1, 2000
Citation Information: J Clin Invest. 2000;106(3):385-392. https://doi.org/10.1172/JCI9896.
Citation Information: J Clin Invest. 2000;106(3):385-392. https://doi.org/10.1172/JCI9896.
Abstract
We used intravital microscopy to observe the formation of platelet plugs in ferric chloride–injured arterioles of live mice. With this model, we evaluated thrombus growth in mice lacking von Willebrand factor (vWF) and fibrinogen (Fg), the two key ligands known to mediate platelet adhesion and aggregation. In vWF–/– mice, despite the presence of arterial shear, delayed platelet adhesion occurred and stable thrombi formed. In many mice, a persisting high-shear channel never occluded. Abundant thrombi formed in Fg–/– mice, but they detached from the subendothelium, which ultimately caused downstream occlusion in all cases. Surprisingly, mice deficient in both vWF and Fg successfully formed thrombi with properties characteristic of both mutations, leading to vessel occlusion in the majority of vessels. Platelets of these doubly deficient mice specifically accumulated fibronectin in their α-granules, suggesting that fibronectin could be the ligand supporting the platelet aggregation.
Authors
Heyu Ni, Cécile V. Denis, Sangeetha Subbarao, Jay L. Degen, Thomas N. Sato, Richard O. Hynes, Denisa D. Wagner
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Citation information
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Theranostics | 2015 |
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Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia
B Vadasz, P Chen, I Yougbaré, D Zdravic, J Li, C Li, N Carrim, H Ni |
Genes & Diseases | 2015 |
|
Transport Regulation of Two-Dimensional Receptor-Ligand Association
L Ju, J Qian, C Zhu |
Biophysical Journal | 2015 |
|
Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis
Hou Y, Carrim N, Wang Y, Gallant RC, Marshall A, Ni H |
Journal of Biomedical Research | 2015 |
|
Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice
A Fotinos, M Klier, NS Gowert, P Münzer, C Klatt, S Beck, O Borst, P Billuart, M Schaller, F Lang, M Gawaz, M Elvers |
Journal of Thrombosis and Haemostasis | 2015 |
|
Four-Dimensional Characterization of Thrombosis in a Live-Cell, Shear-Flow Assay: Development and Application to Xenotransplantation
DG Harris, PK Benipal, X Cheng, L Burdorf, AM Azimzadeh, RN Pierson, M Chrzanowska-Wodnicka |
PloS one | 2015 |
|
Analysis of the influence of antithrombin on microvascular thrombosis: anti-inflammation is crucial for anticoagulation
H Sorg, JO Hoffmann, JN Hoffmann, B Vollmar |
Intensive Care Medicine Experimental | 2015 |
|
Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia
B Vadasz, P Chen, I Yougbaré, D Zdravic, J Li, C Li, N Carrim, H Ni |
Genes & Diseases | 2015 |
|
Resolution of fibrinogen deficiency in a patient with congenital afibrinogenemia after liver transplantation
N Gallastegui, EL Kimble, TJ Harrington |
Haemophilia | 2015 |
|
Ferric chloride thrombosis model: unravelling the vascular effects of a highly corrosive oxidant
SM Schoenwaelder, SP Jackson |
Blood | 2015 |
|
Lys-plasminogen stimulates vitronectin exposure on the platelet surface
DD Zhernossekov, YM Roka-Moiia, AA Tykhomyrov, TV Grinenko |
Biopolymers and Cell | 2015 |
|
Thromboembolic events in patients with severe inherited fibrinogen deficiency
A Rottenstreich, A Lask, L Schliamser, A Zivelin, U Seligsohn, Y Kalish |
Journal of Thrombosis and Thrombolysis | 2015 |
|
Factor concentrates for rare congenital coagulation disorders: where are we now?
A Casini, P Moerloose |
Expert Opinion on Orphan Drugs | 2015 |
|
Plasma fibronectin is an important hemostatic factor and a unique thrombosis regulator
Yiming Wang, Adili Reheman, Christopher Spring, Jalil Kalantari, Alexandra Marshall, Alisa S. Wolberg, Peter Gross, Jeffrey I. Weitz, Margaret Rand, Deane Mosher, John Freedman, Heyu Ni |
Journal of Clinical Investigation | 2014 |
|
Platelet PI3K and GSK3 regulate thrombus stability at a high shear rate
PA Laurent, S Severin, B Hechler, B Vanhaesebroeck, B Payrastre, MP Gratacap |
Blood | 2014 |
|
Thrombospondin 1 requires von Willebrand factor to modulate arterial thrombosis in mice
P Prakash, PP Kulkarni, AK Chauhan |
Blood | 2014 |
|
Of von Willebrand factor and platelets
M Bryckaert, JP Rosa, CV Denis, PJ Lenting |
Cellular and Molecular Life Sciences | 2014 |
|
von Willebrand factor, Jedi knight of the bloodstream
TA Springer |
Blood | 2014 |
|
Involvement of neutrophils in thrombus formation in living mice
R Darbousset, S Mezouar, F Dignat-George, L Panicot-Dubois, C Dubois |
Pathologie Biologie | 2014 |
|
Novel aspects of platelet aggregation
YM Roka-Moya, VL Bilous, DD Zhernossekov, TV Grinenko |
Biopolymers and Cell | 2014 |
|
Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis
W Du, PF Wu, LM Qing, CY Wang, JY Liang, F Yu, JY Tang |
Inflammation | 2014 |
|
The fibrinogen but not the Factor VIII content of transfused plasma determines its effectiveness at reducing bleeding in coagulopathic mice: Plasma Transfusion in Coagulopathic Mice
LJ Eltringham-Smith, X Lei, A Reheman, MD Lambourne, EL Pryzdial, H Ni, WP Sheffield |
Transfusion | 2014 |
|
The various states of von Willebrand factor and their function in physiology and pathophysiology:
V Huck, MF Schneider, C Gorzelanny, SW Schneider |
Thrombosis and Haemostasis | 2014 |
|
FGB mutations leading to congenital quantitative fibrinogen deficiencies: An update and report of four novel mutations
A Casini, S Lukowski, VL Quintard, A Crutu, M Zak, S Regazzoni, P Moerloose, M Neerman-Arbez |
Thrombosis Research | 2014 |
|
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
|
Red blood cells mediate the onset of thrombosis in the ferric chloride murine model
Justin D. Barr, Anil K. Chauhan, Gilbert V. Schaeffer, Jessica K. Hansen, David G. Motto |
Blood | 2013 |
|
Emerging Understanding of Roles for Arterioles in Inflammation
R Sumagin, IH Sarelius |
Microcirculation | 2013 |
|
Von Willebrand Factor Abnormalities Studied in the Mouse Model: What We Learned about VWF Functions
C Casari, PJ Lenting, OD Christophe, CV Denis |
Mediterranean journal of hematology and infectious diseases | 2013 |
|
High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo
VR Taqueti, FA Jaffer |
Integrative Biology | 2013 |
|
Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner
E Westein, AD van der Meer, MJ Kuijpers, JP Frimat, A Berg, JW Heemskerk |
Proceedings of the National Academy of Sciences | 2013 |
|
Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice
K Martinod, M Demers, TA Fuchs, SL Wong, A Brill, M Gallant, J Hu, Y Wang, DD Wagner |
Proceedings of the National Academy of Sciences | 2013 |
|
The effects of arterial flow on platelet activation, thrombus growth, and stabilization
JM Cosemans, A Angelillo-Scherrer, NJ Mattheij, JW Heemskerk |
Cardiovascular Research | 2013 |
|
Haemodilution-induced changes in coagulation and effects of haemostatic components under flow conditions
S Ogawa, T Ohnishi, K Hosokawa, F Szlam, EP Chen, KA Tanaka |
British Journal of Anaesthesia | 2013 |
|
Pulmonary embolism in a patient with congenital afibrinogenemia
J Chapin, M DeSancho |
Haemophilia | 2013 |
|
Encryption and decryption of tissue factor
VM Chen, PJ Hogg |
Journal of Thrombosis and Haemostasis | 2013 |
|
Fibrin(ogen) and thrombotic disease
RA Ariëns |
Journal of Thrombosis and Haemostasis | 2013 |
|
Shear-Responsive Platelet Mimetics for Targeted Drug Delivery
N Korin, M Kanapathipillai, DE Ingber |
Israel Journal of Chemistry | 2013 |
|
Statins as regulators of redox signalling in platelets
F Violi, P Pignatelli |
Antioxidants & Redox Signaling | 2013 |
|
Contribution of blood platelets to vascular pathology in Alzheimer's disease
W Zhang, W Huang, F Jing |
Journal of blood medicine | 2013 |
|
Coagulation and the vessel wall in pulmonary embolism
S Alias, IM Lang |
Pulmonary circulation | 2013 |
|
Synergistic Effect of AJW200, a von Willebrand Factor Neutralizing Antibody with Low Dose (0.9 mg/mg) Thrombolytic Therapy Following Embolic Stroke in Rabbits
PA Lapchak, S Doyan, X Fan, CM Woods |
Journal of neurology & neurophysiology | 2013 |
|
Perioperative factor concentrate therapy
KA Tanaka, S Esper, D Bolliger |
British Journal of Anaesthesia | 2013 |
|
Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment
PF Lalor, J Herbert, R Bicknell, DH Adams |
AJP Gastrointestinal and Liver Physiology | 2013 |
|
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
HG Vogel, J Maas, FJ Hock, D Mayer |
2013 | |
|
GDF-15 prevents platelet integrin activation and thrombus formation
J Rossaint, D Vestweber, A Zarbock |
Journal of Thrombosis and Haemostasis | 2012 |
|
The mouse dorsal skinfold chamber as a model for the study of thrombolysis by intravital microscopy :
Y Boulaftali, L Lamrani, MC Rouzaud, S Loyau, M Jandrot-Perrus, MC Bouton, B Ho-Tin-Noé |
Thrombosis and Haemostasis | 2012 |
|
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
C Li, J Li, Y Li, S Lang, I Yougbare, G Zhu, P Chen, H Ni |
Advances in Hematology | 2012 |
|
Plant Food Delphinidin-3-Glucoside Significantly Inhibits Platelet Activation and Thrombosis: Novel Protective Roles against Cardiovascular Diseases
Y Yang, Z Shi, A Reheman, JW Jin, C Li, Y Wang, MC Andrews, P Chen, G Zhu, W Ling, H Ni |
PloS one | 2012 |
|
ADAMTS13 exerts a thrombolytic effect in microcirculation:
M Crescente, GM Thomas, M Demers, JR Voorhees, SL Wong, B Ho-Tin-Noé, DD Wagner |
Thrombosis and Haemostasis | 2012 |
|
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
N Korin, M Kanapathipillai, BD Matthews, M Crescente, A Brill, T Mammoto, K Ghosh, S Jurek, SA Bencherif, D Bhatta, AU Coskun, CL Feldman, DD Wagner, DE Ingber |
Science | 2012 |
|
New Models of Hemostasis
M McMichael |
Topics in Companion Animal Medicine | 2012 |
|
In vitro and in vivo evaluation of the effect of elevated factor VIII on the thrombogenic process:
M Golder, J Mewburn, D Lillicrap |
Thrombosis and Haemostasis | 2012 |
|
Rotational Thromboelastometry (ROTEM)-Based Coagulation Management in Cardiac Surgery and Major Trauma
KA Tanaka, D Bolliger, R Vadlamudi, A Nimmo |
Journal of Cardiothoracic and Vascular Anesthesia | 2012 |
|
Platelets, glycoprotein Ib-IX, and von Willebrand factor are required for FeCl(3)-induced occlusive thrombus formation in the inferior vena cava of mice
MV Joglekar, J Ware, J Xu, ME Fitzgerald, TK Gartner |
Platelets | 2012 |
|
Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment
PF Lalor, J Herbert, R Bicknell, DH Adams |
American journal of physiology. Gastrointestinal and liver physiology | 2012 |
|
Extracellular Matrix Proteins in Hemostasis and Thrombosis
W Bergmeier, RO Hynes |
Cold Spring Harbor perspectives in biology | 2012 |
|
Plant Food Delphinidin-3-Glucoside Significantly Inhibits Platelet Activation and Thrombosis: Novel Protective Roles against Cardiovascular Diseases
Y Yang, Z Shi, A Reheman, JW Jin, C Li, Y Wang, MC Andrews, P Chen, G Zhu, W Ling, H Ni, C Schulz |
PloS one | 2012 |
|
Cadherin 6 Has a Functional Role in Platelet Aggregation and Thrombus Formation
E Dunne, CM Spring, A Reheman, W Jin, MC Berndt, DK Newman, PJ Newman, H Ni, D Kenny |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
|
Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis
TA Fuchs, A Brill, DD Wagner |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
|
von Willebrand Factor: An Emerging Target in Stroke Therapy
SF Meyer, G Stoll, DD Wagner, C Kleinschnitz |
Stroke; a journal of cerebral circulation | 2012 |
|
N-Acetylcysteine Reduces the Size and Activity of von Willebrand Factor: A Potential Therapy for Thrombotic Thrombocytopenic Purpura
Junmei Chen, Adili Reheman, Francisca Gushiken, Leticia Nolasco, Xiaoyun Fu, Joel Moake, Heyu Ni, José López |
Journal of Clinical Investigation | 2011 |
|
Maternal immune response to fetal platelet GPIbalpha causes frequent miscarriage that can be prevented by intravenous IgG and anti-FcRn therapies
Conglei Li, Siavash Piran, Pingguo Chen, Sean Lang, Alessandro Zarpellon, Joseph Jin, Guangheng Zhu, Adili Reheman, Dianne van der Wal, Elisa Simpson, Ran Ni, Peter Gross, Jerry Ware, Zaverio Ruggeri, John Freedman, Heyu Ni |
Journal of Clinical Investigation | 2011 |
|
Arterial thrombosis—insidious, unpredictable and deadly
SP Jackson |
Nature Medicine | 2011 |
|
Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation
G Passacquale, A Ferro |
British Journal of Clinical Pharmacology | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
Platelets and Megakaryocytes
JM Gibbins, MP Mahaut-Smith |
Platelets and Megakaryocytes | 2011 |
|
The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy
M Stolla, L Stefanini, RC Roden, M Chavez, J Hirsch, T Greene, TD Ouellette, SF Maloney, SL Diamond, M Poncz, DS Woulfe, W Bergmeier |
Blood | 2011 |
|
Extracellular matrix proteins in hemostasis and thrombosis
W Bergmeier, RO Hynes |
Cold Spring Harbor perspectives in biology | 2011 |
|
Von Willebrand Disease
PM Mannucci, M Franchini |
Von Willebrand Disease | 2011 |
|
Platelets at work in primary hemostasis
K Broos, HB Feys, SF de Meyer, K Vanhoorelbeke, H Deckmyn |
Blood Reviews | 2011 |
|
Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?
F Violi, S Basili, V Raparelli, P Chowdary, A Gatt, AK Burroughs |
Journal of Hepatology | 2011 |
|
Elevated fibrinogen causes thrombosis
RA Ariens |
Blood | 2011 |
|
Mechanisms underlying FeCl3-induced arterial thrombosis
A Eckly, B Hechler, M Freund, M Zerr, JP Cazenave, F Lanza, PH Mangin, C Gachet |
Journal of Thrombosis and Haemostasis | 2011 |
|
A ride with ferric chloride
A Brill |
Journal of Thrombosis and Haemostasis | 2011 |
|
Polymers for the rapid and effective activation and aggregation of platelets
A Hansen, L McMillan, A Morrison, J Petrik, M Bradley |
Biomaterials | 2011 |
|
Plasma and cellular fibronectin: distinct and independent functions during tissue repair
WS To, KS Midwood |
Fibrogenesis & Tissue Repair | 2011 |
|
High mortality associated with intracardiac and intrapulmonary thromboses after cardiopulmonary bypass
S Ogawa, JE Richardson, T Sakai, M Ide, KA Tanaka |
Journal of Anesthesia | 2011 |
|
Diminished Thrombogenic Responses by Deletion of the Podocalyxin Gene in Mouse Megakaryocytes
M Pericacho, S Alonso-Martín, S Larrucea, C González-Manchón, D Fernández, I Sánchez, MS Ayuso, R Parrilla |
PloS one | 2011 |
|
The Role of Platelets in Atherothrombosis
ZS Kaplan, SP Jackson |
Hematology | 2011 |
|
Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin
A Bültmann, Z Li, S Wagner, M Peluso, T Schönberger, C Weis, I Konrad, K Stellos, S Massberg, B Nieswandt, M Gawaz, M Ungerer, G Münch |
Journal of Molecular and Cellular Cardiology | 2010 |
|
Platelet receptor signaling in thrombus formation
D Stegner, B Nieswandt |
Journal of Molecular Medicine | 2010 |
|
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear
MA Berny, IC Munnix, JM Auger, SE Schols, JM Cosemans, P Panizzi, PE Bock, SP Watson, OJ McCarty, JW Heemskerk |
PloS one | 2010 |
|
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
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Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
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Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
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Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
|
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
|
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
|
Anticoagulants, Antiplatelets, and Thrombolytics
SA Mousa |
2010 | |
|
Burger's Medicinal Chemistry and Drug Discovery
S Bruno, L Ronda, S Faggiano, S Bettati, A Mozzarelli |
Burger's Medicinal Chemistry and Drug Discovery | 2010 |
|
Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis
RE Rumbaut, P Thiagarajan |
Colloquium Series on Integrated Systems Physiology: From Molecule to Function | 2010 |
|
Postgraduate Haematology
PM Mannucci, F Peyvandi, R Palla |
Postgraduate Haematology | 2010 |
|
Mice with deleted multimerin 1 and α-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1
A Reheman, S Tasneem, H Ni, CP Hayward |
Thrombosis Research | 2010 |
|
Emerging roles of fibronectin in thrombosis
LM Maurer, BR Tomasini-Johansson, DF Mosher |
Thrombosis Research | 2010 |
|
A ferric chloride induced arterial injury model used as haemostatic effect model
F Møller, M Tranholm |
Haemophilia | 2010 |
|
Inherited disorders of platelet function and challenges to diagnosis of mucocutaneous bleeding
SJ Israels, M El-Ekiaby, T Quiroga, D Mezzano |
Haemophilia | 2010 |
|
The molecular origins of the mechanical properties of fibrin
MR Falvo, OV Gorkun, ST Lord |
Biophysical Chemistry | 2010 |
|
Principles of perioperative coagulopathy
P Innerhofer, J Kienast |
Best Practice & Research Clinical Anaesthesiology | 2010 |
|
Platelet Biology and Implications for Antiplatelet Therapy in Atherothrombotic Disease
G Montalescot |
Clinical and Applied Thrombosis/Hemostasis | 2010 |
|
Platelet adhesion under flow
ZM Ruggeri |
Microcirculation (New York, N.Y. : 1994) | 2009 |
|
von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke
BQ Zhao, AK Chauhan, M Canault, IS Patten, JJ Yang, M Dockal, F Scheiflinger, DD Wagner |
Blood | 2009 |
|
Transforming growth factor- -induced protein (TGFBIp/ ig-h3) activates platelets and promotes thrombogenesis
HJ Kim, PK Kim, SM Bae, HN Son, DS Thoudam, JE Kim, BH Lee, RW Park, IS Kim |
Blood | 2009 |
|
Pathogenesis of thrombosis
B Furie |
Hematology | 2009 |
|
Blood Coagulation: Hemostasis and Thrombin Regulation
KA Tanaka, NS Key, JH Levy |
Anesthesia & Analgesia | 2009 |
|
A deep intronic mutation inFGBcreates a consensus exonic splicing enhancer motif that results in afibrinogenemia caused by aberrant mRNA splicing, which can be corrected in vitro with antisense oligonucleotide treatment
RL Davis, VM Homer, PM George, SO Brennan |
Human Mutation | 2009 |
|
Platelet adhesion to multimerin 1in vitro: influences of platelet membrane receptors, von Willebrand factor and shear
S Tasneem, F Adam, I Minullina, M Pawlikowska, SK Hui, S Zheng, JL Miller, CP Hayward |
Journal of Thrombosis and Haemostasis | 2009 |
|
Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV
T Gui, A Reheman, H Ni, PL Gross, F Yin, D Monroe, PE Monahan, DW Stafford |
Journal of Thrombosis and Haemostasis | 2009 |
|
Dynamics of platelet thrombus formation
SP Jackson, WS Nesbitt, E Westein |
Journal of Thrombosis and Haemostasis | 2009 |
|
Platelets and innate immunity
JW Semple, J Freedman |
Cellular and Molecular Life Sciences | 2009 |
|
TGFBIp: more than meets the eye?
JW Rowley, AS Weyrich, RA Campbell |
Blood | 2009 |
|
Deficiency of von Willebrand factor protects mice from ischemic stroke
C Kleinschnitz, SF de Meyer, T Schwarz, M Austinat, K Vanhoorelbeke, B Nieswandt, H Deckmyn, G Stoll |
Blood | 2009 |
|
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression
H Yang, S Lang, Z Zhai, L Li, WH Kahr, P Chen, J Brkic, CM Spring, MJ Flick, JL Degen, J Freedman, H Ni |
Blood | 2009 |
|
The Effects of Fibrinogen Levels on Thromboelastometric Variables in the Presence of Thrombocytopenia
T Lang, K Johanning, H Metzler, S Piepenbrock, C Solomon, N Rahe-Meyer, KA Tanaka |
Anesthesia & Analgesia | 2009 |
|
In vivo time-lapse microscopy reveals no loss of myonuclei during disuse atrophy in skeletal muscle
Jo C. Bruusgaard Kristian Gundersen |
Journal of Clinical Investigation | 2008 |
|
Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor
A Reheman, H Yang, G Zhu, W Jin, F He, CM Spring, X Bai, PL Gross, J Freedman, H Ni |
Blood | 2008 |
|
Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo
T Hayashi, H Mogami, Y Murakami, T Nakamura, N Kanayama, H Konno, T Urano |
Pflügers Archiv - European Journal of Physiology | 2008 |
|
Evaluation of the physiological significance of botrocetin/ von Willebrand factorin vitrosignaling
J Liu, M Joglekar, J Ware, ME Fitzgerald, CA Lowell, MC Berndt, TK Gartner |
Journal of Thrombosis and Haemostasis | 2008 |
|
The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation
F Banno, AK Chauhan, K Kokame, J Yang, S Miyata, DD Wagner, T Miyata |
Blood | 2008 |
|
Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa
I Marx, OD Christophe, PJ Lenting, A Rupin, MO Vallez, TJ Verbeuren, CV Denis |
Blood | 2008 |
|
Function of von Willebrand factor in haemostasis and thrombosis
AJ Reininger |
Haemophilia | 2008 |
|
Treatment of congenital fibrinogen disorders
P Moerloose, M Neerman-Arbez |
Expert Opinion on Biological Therapy | 2008 |
|
Reduced levels of fibrin (antithrombin I) and antithrombin III underlie coagulopathy following complex cardiac surgery
RM Sniecinski, EP Chen, KA Tanaka |
Blood Coagulation & Fibrinolysis | 2008 |
|
New insights into form and function of fibronectin splice variants
ES White, FE Baralle, AF Muro |
The Journal of Pathology | 2008 |
|
CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo
C Wong, Y Liu, J Yip, R Chand, JL Wee, L Oates, B Nieswandt, A Reheman, H Ni, N Beauchemin, DE Jackson |
Blood | 2008 |
|
Molecular Imaging
JC Wu |
Journal of the American College of Cardiology | 2008 |
|
Molecular regulation of platelet adhesion
MC BERNDT, RK ANDREWS |
Japanese Journal of Thrombosis and Hemostasis | 2008 |
|
Platelet function in intravascular device implant-induced intimal injury
B Tesfamariam |
Cardiovascular Revascularization Medicine | 2008 |
|
Afibrinogenemia resulting from homozygous nonsense mutation in A alpha chain gene associated with multiple thrombotic episodes
I Simsek, P Mazancourt, MH Horellou, H Erdem, S Pay, A Dinc, MM Samama |
Blood Coagulation & Fibrinolysis | 2008 |
|
Rare inherited disorders of fibrinogen
SS Acharya, DM Dimichele |
Haemophilia | 2008 |
|
Fibrinogen and von Willebrand factor mediated platelet adhesion to polystyrene under flow conditions
M Zhang, Y Wu, K Hauch, TA Horbett |
Journal of Biomaterials Science, Polymer Edition | 2008 |
|
In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation
JA Guerrero, G Shafirstein, S Russell, KI Varughese, T Kanaji, J Liu, TK Gartner, W Bäumler, GE Jarvis, J Ware |
Journal of Thrombosis and Haemostasis | 2008 |
|
Multimerin 1
SB Jeimy, S Tasneem, EM Cramer, CP Hayward |
Platelets | 2008 |
|
Degradation of Circulating von Willebrand Factor and Its Regulator ADAMTS13 Implicates Secreted Bacillus anthracis Metalloproteases in Anthrax Consumptive Coagulopathy
MC Chung, TG Popova, SC Jorgensen, L Dong, V Chandhoke, CL Bailey, SG Popov |
The Journal of biological chemistry | 2008 |
|
Thrombin-initiated platelet activation in vivo is von Willebrand factor-independent during thrombus formation in a laser injury model
Christophe Dubois Laurence Panicot-Dubois Justin Gainor Barbara C. Furie Bruce Furie |
Journal of Clinical Investigation | 2007 |
|
Mice lacking the signaling molecule, CalDAG-GEFI, represent a model for leukocyte adhesion deficiency type III
Wolfgang Bergmeier, Tobias Goerge, Hong-Wei Wang, Jill R. Crittenden, Andrew C.W. Baldwin, Stephen M. Cifuni, David E. Housman, Ann M. Graybiel, and Denisa D. Wagner |
Journal of Clinical Investigation | 2007 |
|
The growing complexity of platelet aggregation
SP Jackson |
Blood | 2007 |
|
In vivo thrombus formation: In vivo thrombus formation
B FURIE, BC Furie |
Journal of Thrombosis and Haemostasis | 2007 |
|
Mutations in the fibrinogen gene cluster accounting for congenital afibrinogenemia: an update and report of 10 novel mutations
M Neerman-Arbez, P Moerloose |
Human Mutation | 2007 |
|
Platelet integrins and immunoreceptors
A Kasirer-Friede, ML Kahn, SJ Shattil |
Immunological Reviews | 2007 |
|
The C-terminus of ?2-antiplasmin interacts with endothelial cells
L Thomas, NR Moore, S Miller, NA Booth |
British Journal of Haematology | 2007 |
|
A mechanism to safeguard platelet adhesion under high shear flow: von Willebrand factor?glycoprotein Ib and integrin ?2?1?collagen interactions make complementary, collagen-type-specific contributions to adhesion
M Moroi, SM Jung |
Journal of Thrombosis and Haemostasis | 2007 |
|
Programmed autologous cleavage of platelet receptors
MC Berndt, D Karunakaran, EE Gardiner, RK Andrews |
Journal of Thrombosis and Haemostasis | 2007 |
|
Vascular bed-specific thrombosis
WC Aird |
Journal of Thrombosis and Haemostasis | 2007 |
|
Fibrinogen controls human platelet fibronectin internalization and cell-surface retention
Z Zhai, J Wu, X Xu, K Ding, R Ni, W Hu, Z Sun, H Ni |
Journal of Thrombosis and Haemostasis | 2007 |
|
Preclinical toxicity biomarkers for combination treatment with clotting factors rFXIII and rFVIIa
MB Oleksiewicz, R Schaal-Jensen, B Kiehr, JS Krabbe, C Sommer |
Biomarkers | 2007 |
|
Platelet Activation and Atherothrombosis
G Davì, C Patrono |
New England Journal of Medicine | 2007 |
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In vivo response to vascular injury in the absence of factor IX: Examination in factor IX knockout mice
T Gui, A Reheman, WK Funkhouser, DA Bellinger, JR Hagaman, DW Stafford, PE Monahan, H Ni |
Thrombosis Research | 2007 |
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Segregation of Platelet Aggregatory and Procoagulant Microdomains in Thrombus Formation: Regulation by Transient Integrin Activation
IC Munnix, MJ Kuijpers, J Auger, CM Thomassen, P Panizzi, MA van Zandvoort, J Rosing, PE Bock, SP Watson, JW Heemskerk |
Arteriosclerosis, thrombosis, and vascular biology | 2007 |
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Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo
H Yang, A Reheman, P Chen, G Zhu, RO Hynes, J Freedman, DD Wagner, H Ni |
Journal of Thrombosis and Haemostasis | 2006 |
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Systemic antithrombotic effects of ADAMTS13
AK Chauhan, DG Motto, CB Lamb, W Bergmeier, M Dockal, B Plaimauer, F Scheiflinger, D Ginsburg, DD Wagner |
Journal of Experimental Medicine | 2006 |
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von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins
AK Chauhan, J Kisucka, CB Lamb, W Bergmeier, DD Wagner |
Blood | 2006 |
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Thrombus Formation In a Living Mouse
B Furie, BC Furie |
Journal of Clinical Investigation | 2006 |
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Role of fibronectin assembly in platelet thrombus formation
J Cho, DF Mosher |
Journal of Thrombosis and Haemostasis | 2006 |
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Distinct antithrombotic consequences of platelet glycoprotein Ibα and VI deficiency in a mouse model of arterial thrombosis
S Konstantinides, J Ware, P Marchese, F Almus-Jacobs, DJ Loskutoff, ZM Ruggeri |
Journal of Thrombosis and Haemostasis | 2006 |
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The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
W Bergmeier, CL Piffath, T Goerge, SM Cifuni, ZM Ruggeri, J Ware, DD Wagner |
Proceedings of the National Academy of Sciences | 2006 |
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Activation-independent platelet adhesion and aggregation under elevated shear stress
ZM Ruggeri, JN Orje, R Habermann, AB Federici, AJ Reininger |
Blood | 2006 |
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Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13
A Bonnefoy, K Daenens, HB Feys, RD Vos, P Vandervoort, J Vermylen, J Lawler, MF Hoylaerts |
Blood | 2006 |
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Glanzmann thrombasthenia
AT Nurden |
Orphanet Journal of Rare Diseases | 2006 |
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Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo
J Liu, ME Fitzgerald, MC Berndt, CW Jackson, TK Gartner |
Blood | 2006 |
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Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
ER Vandendries, JR Hamilton, SR Coughlin, B Furie, BC Furie |
Proceedings of the National Academy of Sciences | 2006 |
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Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
J Kisucka, CE Butterfield, DG Duda, SC Eichenberger, S Saffaripour, J Ware, ZM Ruggeri, RK Jain, J Folkman, DD Wagner |
Proceedings of the National Academy of Sciences | 2006 |
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Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase
JU Peter, N Alenina, M Bader, DJ Walther |
Molecular and Cellular Biochemistry | 2006 |
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The Synergy Site of Fibronectin Is Required for Strong Interaction with the Platelet Integrin αIIbβ3
D Chada, T Mather, MU Nollert |
Annals of Biomedical Engineering | 2006 |
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Platelet interactions with vessel wall components during thrombogenesis
ZM Ruggeri |
Blood Cells, Molecules, and Diseases | 2006 |
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Unveiling the new face of fibronectin in thrombosis and hemostasis
H Ni |
Journal of Thrombosis and Haemostasis | 2006 |
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ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb vs. P2X1
C Oury, K Daenens, H Hu, E Toth-Zsamboki, M Bryckaert, MF Hoylaerts |
Journal of Thrombosis and Haemostasis | 2006 |
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Relationship between lipoprotein(a), fibrinogen, and fibronectin in non-diabetic hemodialyzed uremic patients
HA Tzanatos, K Retsa, L Soubassi, D Rizos, M Skiadas, G Bougatsos, B Agroyannis |
Dialysis & Transplantation | 2006 |
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Expression of functional recombinant mosquito salivary apyrase: A potential therapeutic platelet aggregation inhibitor
D Sun, A Mcnicol, AA James, Z Peng |
Platelets | 2006 |
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Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets
H Schwertz, ND Tolley, JM Foulks, MM Denis, BW Risenmay, M Buerke, RE Tilley, MT Rondina, EM Harris, LW Kraiss, N Mackman, GA Zimmerman, AS Weyrich |
Journal of Experimental Medicine | 2006 |
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Thrombus Formation In a Living Mouse
B Furie, BC Furie |
Pathophysiology of Haemostasis and Thrombosis | 2006 |
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Middle Cerebral Arterial Thrombosis in a Patient with Hypofibrinogenemia, 5 Days After rFVIIa and FFP Infusion
T Patiroglu, M Karakukcu |
Clinical and Applied Thrombosis/Hemostasis | 2006 |
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The Vascular Endothelium II
S Moncada, A Higgs |
2006 | |
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Size regulation of von Willebrand factor–mediated platelet thrombi by ADAMTS13 in flowing blood
R Donadelli, JN Orje, C Capoferri, G Remuzzi, ZM Ruggeri |
Blood | 2006 |
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Glycoprotein VI–dependent and –independent pathways of thrombus formation in vivo
C Dubois, L Panicot-Dubois, G Merrill-Skoloff, B Furie, BC Furie |
Blood | 2006 |
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The P-selectin, tissue factor, coagulation triad
J Polgar, J Matuskova, DD Wagner |
Journal of Thrombosis and Haemostasis | 2005 |
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Fibrinogen and fibrin structure and functions
MW Mosesson |
Journal of Thrombosis and Haemostasis | 2005 |
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Platelets in atherothrombosis: lessons from mouse models
B Nieswandt, B Aktas, A Moers, U Sachs |
Journal of Thrombosis and Haemostasis | 2005 |
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Thrombus formation in vivo
B Furie, BC Furie |
Journal of Clinical Investigation | 2005 |
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Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation
A Reheman, P Gross, H Yang, P Chen, D Allen, V Leytin, J Freedman, H Ni |
Journal of Thrombosis and Haemostasis | 2005 |
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Vitronectin: back into the spotlight
EF Plow |
Journal of Thrombosis and Haemostasis | 2005 |
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New perspectives on von Willebrand factor functions in hemostasis and thrombosis
GL Mendolicchio, ZM Ruggeri |
Seminars in Hematology | 2005 |
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Factor V Leiden improves in vivo hemostasis in murine hemophilia models
A Schlachterman, J Schuettrumpf, JH Liu, CF Freguia, R Toso, M Poncz, RM Camire, VR Arruda |
Journal of Thrombosis and Haemostasis | 2005 |
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Snake venom probes of platelet adhesion receptors and their ligands
LC Wijeyewickrema, MC Berndt, RK Andrews |
Toxicon | 2005 |
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Fibrin but Not Adsorbed Fibrinogen Supports Fibronectin Assembly by Spread Platelets: EFFECTS OF THE INTERACTION OF αIIbβ3 WITH THE C TERMINUS OF THE FIBRINOGEN γ-CHAIN
J Cho, JL Degen, BS Coller, DF Mosher |
The Journal of biological chemistry | 2005 |
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Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin
YP Wu, HJ Bloemendal, EE Voest, T Logtenberg, PG de Groot, MF Gebbink, HC de Boer |
Blood | 2004 |
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Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction
JS Palumbo, M Zogg, KE Talmage, JL Degen, H Weiler, BH Isermann |
Journal of Thrombosis and Haemostasis | 2004 |
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A new role in hemostasis for the adhesion receptor P-selectin
B Cambien, DD Wagner |
Trends in Molecular Medicine | 2004 |
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alphaIIbbeta3 antagonism vs. antiadhesive treatment to prevent platelet interactions with vascular subendothelium
E Melis, A Bonnefoy, K Daenens, H Yamamoto, J Vermylen, MF Hoylaerts |
Journal of Thrombosis and Haemostasis | 2004 |
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Pregnancy-related thrombosis in a woman with congenital afibrinogenemia: A report of two successful pregnancies
H Roqu�, C Stephenson, MJ Lee, EF Funai, D Popiolek, E Kim, D Hart |
American Journal of Hematology | 2004 |
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Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion
OJ Mccarty, Y Zhao, N Andrew, LM Machesky, D Staunton, J Frampton, SP Watson |
Journal of Thrombosis and Haemostasis | 2004 |
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Platelet physiology and thrombosis
RK Andrews, MC Berndt |
Thrombosis Research | 2004 |
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Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency
E Camerer |
Blood | 2004 |
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Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation
J Chou |
Blood | 2004 |
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The Physiological Genomics of the Critically Ill Mouse
C Ince |
2004 | |
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Transgenic Models in Pharmacology
S Offermanns, L Hein |
2004 | |
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P2Y12 as the hub of the platelet activation process. P2Y12 regulates platelet adhesion/activation, thrombus growth and thrombus stability in injured arteries.
Patrick Andre, Suzanne Delaney, Thomas LaRocca, Diana Vincent, Francis DeGuzman, Marzena Jurek, Beverley Koller, David R. Phillips, Pamela B. Conley |
Journal of Clinical Investigation | 2003 |
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Anti-thrombotic activity of Tumor Necrosis Factor-alpha
Beatrice Cambien, Wolfgang Bergmeier, Simin Saffaripour, Heather A. Mitchell, Denisa D. Wagner |
Journal of Clinical Investigation | 2003 |
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Antiplatelet therapy: in search of the 'magic bullet'
SP Jackson, SM Schoenwaelder |
Nature Reviews Drug Discovery | 2003 |
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Thrombospondin‐1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor
K Jurk, KJ Clemetson, PG Groot, MF Brodde, M Steiner, N Savion, D Varon, JJ Sixma, HV Aken, BE Kehrel |
The FASEB Journal | 2003 |
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Fibrinogen gamma chain functions
MW Mosesson |
Journal of Thrombosis and Haemostasis | 2003 |
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Inhibition of von Willebrand factor-GPIb/IX/V interactions as a strategy to prevent arterial thrombosis
A Bonnefoy, J Vermylen, MF Hoylaerts |
Expert Review of Cardiovascular Therapy | 2003 |
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Von Willebrand factor
ZM Ruggeri |
Current Opinion in Hematology | 2003 |
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Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor
K Matsushita, CN Morrell, B Cambien, SX Yang, M Yamakuchi, C Bao, MR Hara, RA Quick, W Cao, B O'Rourke, JM Lowenstein, J Pevsner, DD Wagner, CJ Lowenstein |
Cell | 2003 |
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Signaling events underlying thrombus formation
SP Jackson, WS Nesbitt, S Kulkarni |
Journal of Thrombosis and Haemostasis | 2003 |
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Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host Defense
AR Gear, D Camerini |
Microcirculation | 2003 |
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Intercellular calcium communication regulates platelet aggregation and thrombus growth
WS Nesbitt, S Giuliano, S Kulkarni, SM Dopheide, IS Harper, SP Jackson |
The Journal of Cell Biology | 2003 |
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Plasma fibronectin promotes thrombus growth and stability in injured arterioles
H Ni, PS Yuen, JM Papalia, JE Trevithick, T Sakai, R Fässler, RO Hynes, DD Wagner |
Proceedings of the National Academy of Sciences | 2003 |
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Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor
K Matsushita, CN Morrell, B Cambien, SX Yang, M Yamakuchi, C Bao, MR Hara, RA Quick, W Cao, B O'Rourke, JM Lowenstein, J Pevsner, DD Wagner, CJ Lowenstein |
Cell | 2003 |
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Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release
DJ Walther, JU Peter, S Winter, M Höltje, N Paulmann, M Grohmann, J Vowinckel, V Alamo-Bethencourt, CS Wilhelm, G Ahnert-Hilger, M Bader |
Cell | 2003 |
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Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen
M Jirousková, I Chereshnev, H Väänänen, JL Degen, BS Coller |
Blood | 2003 |
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Platelets in hemostasis and thrombosis: role of integrins and their ligands
H Ni, J Freedman |
Transfusion and Apheresis Science | 2003 |
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Von Willebrand factor, platelets and endothelial cell interactions
Z M Ruggeri |
Journal of Thrombosis and Haemostasis | 2003 |
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Integrin α IIb β 3 -dependent Calcium Signals Regulate Platelet-Fibrinogen Interactions under Flow: INVOLVEMENT OF PHOSPHOLIPASE Cγ2
I Goncalves, SC Hughan, SM Schoenwaelder, CL Yap, Y Yuan, SP Jackson |
The Journal of biological chemistry | 2003 |
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Control of thrombus embolization and fibronectin internalization by integrin αIIbβ3 engagement of the fibrinogen γ chain
H Ni, JM Papalia, JL Degen, DD Wagner |
Blood | 2003 |
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Fibrinogen is necessary for platelet function in vivo after all
JS Bennett |
Blood | 2003 |
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Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia
G Theilmeier, C Michiels, E Spaepen, I Vreys, D Collen, J Vermylen, MF Hoylaerts |
Blood | 2002 |
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Fibrinogen Stabilizes Placental-Maternal Attachment During Embryonic Development in the Mouse
T Iwaki, MJ Sandoval-Cooper, M Paiva, T Kobayashi, VA Ploplis, FJ Castellino |
The American Journal of Pathology | 2002 |
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CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism
P André, KS Prasad, CV Denis, M He, JM Papalia, RO Hynes, DR Phillips, DD Wagner |
Nature Medicine | 2002 |
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Platelets in atherothrombosis
ZM Ruggeri |
Nature Medicine | 2002 |
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Zinc Finger Protein, Hzf , Is Required for Megakaryocyte Development and Hemostasis
Y Kimura, A Hart, M Hirashima, C Wang, D Holmyard, J Pittman, XL Pang, CW Jackson, A Bernstein |
Journal of Experimental Medicine | 2002 |
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Vascular PG-M/versican variants promote platelet adhesion at low shear rates and cooperate with collagens to induce aggregation
M Mazzucato, MR Cozzi, P Pradella, D Perissinotto, A Malmström, M Mörgelin, P Spessotto, A Colombatti, LD Marco, R Perris |
The FASEB Journal | 2002 |
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Drug Discovery and Evaluation
HG Vogel, WH Vogel, BA Schölkens, J Sandow, G Müller, WF Vogel |
2002 | |
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Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin αIIbβ3
CL Yap, KE Anderson, SC Hughan, SM Dopheide, HH Salem, SP Jackson |
Blood | 2002 |
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Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow
H Matsui, M Sugimoto, T Mizuno, S Tsuji, S Miyata, M Matsuda, A Yoshioka |
Blood | 2002 |
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Leptin promotes platelet aggregation and arterial thrombosis in vivo: A potential mechanism for atherothrombotic disease in obesity
Stavros Konstantinides, Katrin Schäfer, Stefan Koschnick and David J. Loskutoff |
Journal of Clinical Investigation | 2001 |
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Localized reduction of atherosclerosis in von Willebrand factor-deficient mice
N Methia, P André, CV Denis, M Economopoulos, DD Wagner |
Blood | 2001 |
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Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice
D Praticò, C Tillmann, ZB Zhang, H Li, GA FitzGerald |
Proceedings of the National Academy of Sciences | 2001 |
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Japanese Journal of Thrombosis and Hemostasis
M OKUDAIRA, H ASAKURA, Y SANO, Y SUGA, M YAMAZAKI, K AOSHIMA, E MORISHITA, M SAITO, Y ONTACHI, T MIZUTANI, M KATO, T ITO, K MIYAMOTO, S NAKAO |
Japanese Journal of Thrombosis and Hemostasis | 2001 |
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Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation
ZM Ruggeri |
Best Practice & Research Clinical Haematology | 2001 |
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Long-Term Antithrombotic Protection by in Vivo Depletion of Platelet Glycoprotein VI in Mice
B Nieswandt, V Schulte, W Bergmeier, R Mokhtari-Nejad, K Rackebrandt, JP Cazenave, P Ohlmann, C Gachet, H Zirngibl |
Journal of Experimental Medicine | 2001 |
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Genetic Manipulation of Fibrinogen and Fibrinolysis in Mice
JL Degen, AF Drew, JS Palumbo, KW Kombrinck, JA Bezerra, MJ Danton, K Holmbäck, TT Suh |
Annals of the New York Academy of Sciences | 2001 |
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NEW ASPECTS IN THE PATHOGENESIS AND TREATMENT OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND HEMOLYTIC UREMIC SYNDROME
T Raife, R Montgomery |
Reviews in Clinical and Experimental Hematology | 2001 |
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Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
B Nieswandt, V Schulte, W Bergmeier, R Mokhtari-Nejad, K Rackebrandt, JP Cazenave, P Ohlmann, C Gachet, H Zirngibl |
Journal of Experimental Medicine | 2001 |
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Rodent models of susceptibility: what is their place in inhalation toxicology?
UP Kodavanti, DL Costa |
Respiration Physiology | 2001 |
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A role for fibronectin in self-repair after ischemic injury
DF Mosher |
Nature Medicine | 2001 |
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Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation
S Moog, P Mangin, N Lenain, C Strassel, C Ravanat, S Schuhler, M Freund, M Santer, M Kahn, B Nieswandt, C Gachet, JP Cazenave, F Lanza |
Blood | 2001 |
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Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists
OE Olorundare, O Peyruchaud, RM Albrecht, DF Mosher |
Blood | 2001 |
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Insights into Extracellular Matrix Functions from Mutant Mouse Models
E Gustafsson, R Fässler |
Experimental Cell Research | 2000 |
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Platelets
JN George |
The Lancet | 2000 |
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Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
P André, CV Denis, J Ware, S Saffaripour, RO Hynes, ZM Ruggeri, DD Wagner |
Blood | 2000 |
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Hämostaseologie
G Müller-Berghaus, B Pötzsch |
Hämostaseologie | 1999 |
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Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists
H Ni, V Ramakrishnan, ZM Ruggeri, JM Papalia, DR Phillips, DD Wagner |
Blood | 1989 |
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