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Conditionally replicating herpes vectors for cancer therapy
Robert L. Martuza
Robert L. Martuza
Published April 1, 2000
Citation Information: J Clin Invest. 2000;105(7):841-846. https://doi.org/10.1172/JCI9744.
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Conditionally replicating herpes vectors for cancer therapy

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Abstract

Authors

Robert L. Martuza

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Figure 2

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Targeting specific cancer cell types (reproduced from references 29 and ...
Targeting specific cancer cell types (reproduced from references 29 and 30 with permission). G92A expresses ICP4 under the control of an albumin promoter/enhancer sequence and preferentially replicates within albumin expressing cells. Albumin expressing human hepatomas grown in athymic mice are effectively treated by either one or two doses of G92A (left) whereas albumin non-expressing human prostate cancer cells are unaffected (right). In contrast, hrR3, an ICP6-deficient vector that is not promoter regulated is effective against either tumor type.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 9 patents
23 readers on Mendeley
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