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Conditionally replicating herpes vectors for cancer therapy
Robert L. Martuza
Robert L. Martuza
Published April 1, 2000
Citation Information: J Clin Invest. 2000;105(7):841-846. https://doi.org/10.1172/JCI9744.
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Conditionally replicating herpes vectors for cancer therapy

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Abstract

Authors

Robert L. Martuza

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Figure 1

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Targeting HSV to general cancer cell pathways: A general map of HSV-1 de...
Targeting HSV to general cancer cell pathways: A general map of HSV-1 demonstrates the unique long (UL) and unique short (US) sequences of HSV-1 flanked by the long and short repeat sequences. Also shown are the mutations introduced to create the vector G207, which infects and lyses tumor cells efficiently but is not virulent in normal tissue, even the brain.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 9 patents
23 readers on Mendeley
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