Genetic basis of human congenital anomalies of the kidney and urinary tract
Simone Sanna-Cherchi, … , Gian Marco Ghiggeri, Ali G. Gharavi
Simone Sanna-Cherchi, … , Gian Marco Ghiggeri, Ali G. Gharavi
Published January 2, 2018
Citation Information: J Clin Invest. 2018;128(1):4-15. https://doi.org/10.1172/JCI95300.
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Genetic basis of human congenital anomalies of the kidney and urinary tract

Abstract

The clinical spectrum of congenital anomalies of the kidney and urinary tract (CAKUT) encompasses a common birth defect in humans that has significant impact on long-term patient survival. Overall, data indicate that approximately 20% of patients may have a genetic disorder that is usually not detected based on standard clinical evaluation, implicating many different mutational mechanisms and pathogenic pathways. In particular, 10% to 15% of CAKUT patients harbor an unsuspected genomic disorder that increases risk of neurocognitive impairment and whose early recognition can impact clinical care. The emergence of high-throughput genomic technologies is expected to provide insight into the common and rare genetic determinants of diseases and offer opportunities for early diagnosis with genetic testing.

Authors

Simone Sanna-Cherchi, Rik Westland, Gian Marco Ghiggeri, Ali G. Gharavi

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