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Citations to this article

Junctional communication of pancreatic β cells contributes to the control of insulin secretion and glucose tolerance
Anne Charollais, … , Pedro L. Herrera, Paolo Meda
Anne Charollais, … , Pedro L. Herrera, Paolo Meda
Published January 15, 2000
Citation Information: J Clin Invest. 2000;106(2):235-243. https://doi.org/10.1172/JCI9398.
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Junctional communication of pancreatic β cells contributes to the control of insulin secretion and glucose tolerance

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Abstract

Proper insulin secretion requires the coordinated functioning of the numerous β cells that form pancreatic islets. This coordination depends on a network of communication mechanisms whereby β cells interact with extracellular signals and adjacent cells via connexin channels. To assess whether connexin-dependent communication plays a role in vivo, we have developed transgenic mice in which connexin 32 (Cx32), one of the vertebrate connexins found in the pancreas, is expressed in β cells. We show that the altered β-cell coupling that results from this expression causes reduced insulin secretion in response to physiologically relevant concentrations of glucose and abnormal tolerance to the sugar. These alterations were observed in spite of normal numbers of islets, increased insulin content, and preserved secretory response to glucose by individual β cells. Moreover, glucose-stimulated islets showed improved electrical synchronization of these cells and increased cytosolic levels of Ca2+. The results show that connexins contribute to the control of β cells in vivo and that their excess is detrimental for insulin secretion.

Authors

Anne Charollais, Asllan Gjinovci, Joachim Huarte, Juliette Bauquis, Angel Nadal, Franz Martín, Etelvina Andreu, Juan V. Sánchez-Andrés, Alessandra Calabrese, Domenico Bosco, Bernat Soria, Claes B. Wollheim, Pedro L. Herrera, Paolo Meda

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2001 Total
Citations: 2 1 1 1 3 1 2 4 3 1 5 1 1 2 1 1 1 2 4 1 38
Citation information
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Citations to this article (38)

Title and authors Publication Year
Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases
Bkaily G, Jacques D
International journal of molecular sciences 2023
Increased hexosamine biosynthetic pathway flux alters cell–cell adhesion in INS-1E cells and murine islets
Lofrumento DD, Miraglia A, La Pesa V, Treglia AS, Chieppa M, De Nuccio F, Nicolardi G, Miele C, Beguinot F, Garbi C, Di Jeso B
Endocrine 2023
Basal and Stress-Induced Network Activity in the Adrenal Medulla In Vivo
Lopez Ruiz JR, Ernst SA, Holz RW, Stuenkel EL
Frontiers in Endocrinology 2022
Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?
S Bourgeois, T Sawatani, AV Mulders, ND Leu, Y Heremans, H Heimberg, M Cnop, W Staels
Cells 2021
Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes
S Gheibi, T Singh, JP da Cunha, M Fex, H Mulder
Cells 2020
A simple method for the generation of insulin producing cells from bone marrow mesenchymal stem cells
G Daryabor, EH Shiri, E Kamali-Sarvestani
In vitro cellular & developmental biology. Animal 2019
Phenotypic characterization of a novel type 2 diabetes animal model in a SHANXI MU colony of Chinese hamsters
L Wang, C Wang, R Zhang, Y Liu, C Wang, G Song, J Yu, Z Chen
Endocrine 2019
MicroRNA-127 inhibits cell proliferation via targeting Kif3b in pancreatic β cells
Z Shen, H Jiang, HT Hsu, L Qian, Q Fu, M Shen, S Chen, T Yang
Aging 2019
Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans
A Galli, E Maffioli, E Sogne, S Moretti, ES Cairano, A Negri, S Nonnis, GD Norata, F Bonacina, F Borghi, A Podestà, F Bertuzzi, P Milani, C Lenardi, G Tedeschi, C Perego
Scientific Reports 2018
Signals in the pancreatic islet microenvironment influence β-cell proliferation: AAMODT et al
KI Aamodt, AC Powers
Diabetes Obesity and Metabolism 2017
Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells
M Gosak, A Stožer, R Markovič, J Dolenšek, M Perc, MS Rupnik, M Marhl
Frontiers in physiology 2017
Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells
AD Green, S Vasu, NH McClenaghan, PR Flatt
Pflügers Archiv - European Journal of Physiology 2015
Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells
F Lebreton, A Pirog, I Belouah, D Bosco, T Berney, P Meda, Y Bornat, B Catargi, S Renaud, M Raoux, J Lang
Diabetologia 2015
Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion
B Yesildag, T Bock, K Herrmanns, B Wollscheid, M Stoffel
The Journal of biological chemistry 2015
Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis
J Dolenšek, D Špelič, M Klemen, B Žalik, M Gosak, M Rupnik, A Stožer
Sensors (Basel, Switzerland) 2015
Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, L Boesmans, EJ Cauwelier, M Granvik, VP Pruniau, L Van Lommel, J Van Schoors, JS Stancill, I Smolders, V Goffin, N Binart, P in’t Veld, J Declercq, MA Magnuson, JW Creemers, F Schuit, A Schraenen
Cell Metabolism 2014
A Conserved Rule for Pancreatic Islet Organization
DT Hoang, H Matsunari, M Nagaya, H Nagashima, JM Millis, P Witkowski, V Periwal, M Hara, J Jo, T Cai
PloS one 2014
Phase transitions in pancreatic islet cellular networks and implications for type-1 diabetes
Stamper IJ, Jackson E, Wang X
Physical review. E, Statistical, nonlinear, and soft matter physics 2014
Protein-Mediated Interactions of Pancreatic Islet Cells
P Meda
Scientifica 2013
Bursting synchronization dynamics of pancreatic β-cells with electrical and chemical coupling
P Meng, Q Wang, Q Lu
Cognitive neurodynamics 2012
High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton
RW Yeo, K Yang, GD Li, SK Lim
PloS one 2012
Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse
WS Head, ML Orseth, CS Nunemaker, LS Satin, DW Piston, RK Benninger
Diabetes 2012
Changes in MicroRNA Expression Contribute to Pancreatic  -Cell Dysfunction in Prediabetic NOD Mice
E Roggli, S Gattesco, D Caille, C Briet, C Boitard, P Meda, R Regazzi
Diabetes 2012
The In Vivo  -to- -Cell Chat Room: Connexin Connections Matter
P Meda
Diabetes 2012
Connexins protect murine pancreatic β-cells against apoptosis
Philippe Klee, Florent Allagnat, Helena Pontes, Manon Cederroth, Anne Charollais, Dorothée Caille, Aurore Britan, Jacques-Antoine Haefliger, Paolo Meda
Journal of Clinical Investigation 2011
Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells
E Roggli, A Britan, S Gattesco, N Lin-Marq, A Abderrahmani, P Meda, R Regazzi
Diabetes 2010
MODY-like diabetes associated with an apparently balanced translocation: possible involvement of MPP7 gene and cell polarity in the pathogenesis of diabetes
EJ Bhoj, S Romeo, MG Baroni, G Bartov, RA Schultz, AR Zinn
Molecular cytogenetics 2009
In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy
M Villiger, J Goulley, M Friedrich, A Grapin-Botton, P Meda, T Lasser, RA Leitgeb
Diabetologia 2009
The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation
A Nittala, X Wang
Theoretical Biology and Medical Modelling 2008
Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels
E Charpantier, J Cancela, P Meda
Diabetologia 2007
Diffusion of calcium and metabolites in pancreatic islets: killing oscillations with a pitchfork
K Tsaneva-Atanasova, CL Zimliki, R Bertram, A Sherman
Biophysical Journal 2006
Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents
E Somm, P Cettour-Rose, C Asensio, A Charollais, M Klein, C Theander-Carrillo, CE Juge-Aubry, JM Dayer, MJ Nicklin, P Meda, F Rohner-Jeanrenaud, CA Meier
Diabetologia 2005
The estrogenic effect of bisphenol A disrupts pancreatic beta-cell function in vivo and induces insulin resistance
P Alonso-Magdalena, S Morimoto, C Ripoll, E Fuentes, A Nadal
Environmental Health Perspectives 2005
Three roads to islet bursting: emergent oscillations in coupled phantom bursters
CL Zimliki, D Mears, A Sherman
Biophysical Journal 2004
Wave speeds of density dependent Nagumo diffusion equations – inspired by oscillating gap-junction conductance in the islets of Langerhans
MG Pedersen
Journal of Mathematical Biology 2004
Homogenization of Heterogeneously Coupled Bistable ODE's-Applied to Excitation Waves in Pancreatic Islets of Langerhans
MG Pedersen
Journal of Biological Physics 2004
Comparison of Metabolic Oscillations from Mouse Pancreatic Beta Cells and Islets
CS Nunemaker, LS Satin
Endocrine 2004
Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP
EM TenBroek, PD Lampe, JL Solan, JK Reynhout, RG Johnson
The Journal of Cell Biology 2001

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