B cells expressing the transcription factor T-bet drive lupus-like autoimmunity
Kira Rubtsova, … , John W. Kappler, Philippa Marrack
Kira Rubtsova, … , John W. Kappler, Philippa Marrack
Published February 27, 2017
Citation Information: J Clin Invest. 2017;127(4):1392-1404. https://doi.org/10.1172/JCI91250.
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Research Article Autoimmunity Immunology Article has an altmetric score of 109

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

Abstract

B cells contribute to multiple aspects of autoimmune disorders and may play a role in triggering disease. Thus, targeting B cells may be a promising strategy for treating autoimmune disorders. Better understanding of the B cell subsets that are responsible for the development of autoimmunity will be critical for developing efficient therapies. Here we have reported that B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice. B cell–specific deletion of T-bet was also associated with lower activation of both B cells and T cells. Taken together, our results suggest that targeting T-bet–expressing B cells may be a potential target for therapy for autoimmune diseases.

Authors

Kira Rubtsova, Anatoly V. Rubtsov, Joshua M. Thurman, Johanna M. Mennona, John W. Kappler, Philippa Marrack

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