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WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors
Lu Cui, Yuan Guan, Zepeng Qu, Jingfa Zhang, Bing Liao, Bo Ma, Jiang Qian, Dangsheng Li, Weiye Li, Guo-Tong Xu, and Ying Jin
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Published October 3, 2016 - More info
J Clin Invest. 2016;126(10):4061–4061. https://doi.org/10.1172/JCI89436.
Copyright © 2016, American Society for Clinical Investigation
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Abstract
Tumor formation constitutes a major obstacle to the clinical application of embryonic stem cell–derived (ESC-derived) cells. In an attempt to find major extracellular signaling and intrinsic factors controlling tumorigenicity and therapeutic functionality of transplanted ESC-derived retinal progenitor cells (ESC-RPCs), we evaluated multiple kinds of ESC-RPCs in a mouse retinal degeneration model and conducted genome-wide gene expression profiling. We identified canonical WNT signaling as a critical determinant for the tumorigenicity and therapeutic function of ESC-RPCs. The function of WNT signaling is primarily mediated by TCF7, which directly induces expression of
Authors
Lu Cui, Yuan Guan, Zepeng Qu, Jingfa Zhang, Bing Liao, Bo Ma, Jiang Qian, Dangsheng Li, Weiye Li, Guo-Tong Xu, Ying Jin
Original citation: J Clin Invest. 2013;123(4):1647–1661. doi:10.1172/JCI65048.
Citation for this corrigendum: J Clin Invest. 2016;126(10):4061. doi:10.1172/JCI89436.
In Figure 4D, the merged image showing fTCF7, NESTIN, and BrdU staining of Vector-ESC-RPCs and the merged image showing SOX2, PCNA, and BrdU staining of ΔNTcf7-ESC-RPCs were mislabeled. The correctly labeled images are below.
The authors regret the error.
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ISSN: 0021-9738 (print), 1558-8238 (online)