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Claudia Goettsch, … , Sasha A. Singh, Elena Aikawa
Published March 7, 2016
Citation Information: J Clin Invest. 2016;126(4):1323-1336. https://doi.org/10.1172/JCI80851.
Citation Information: J Clin Invest. 2016;126(4):1323-1336. https://doi.org/10.1172/JCI80851.
Abstract
Vascular calcification is a common feature of major cardiovascular diseases. Extracellular vesicles participate in the formation of microcalcifications that are implicated in atherosclerotic plaque rupture; however, the mechanisms that regulate formation of calcifying extracellular vesicles remain obscure. Here, we have demonstrated that sortilin is a key regulator of smooth muscle cell (SMC) calcification via its recruitment to extracellular vesicles. Sortilin localized to calcifying vessels in human and mouse atheromata and participated in formation of microcalcifications in SMC culture. Sortilin regulated the loading of the calcification protein tissue nonspecific alkaline phosphatase (TNAP) into extracellular vesicles, thereby conferring its calcification potential. Furthermore, SMC calcification required Rab11-dependent trafficking and FAM20C/casein kinase 2–dependent C-terminal phosphorylation of sortilin. In a murine model,
Authors
Claudia Goettsch, Joshua D. Hutcheson, Masanori Aikawa, Hiroshi Iwata, Tan Pham, Anders Nykjaer, Mads Kjolby, Maximillian Rogers, Thomas Michel, Manabu Shibasaki, Sumihiko Hagita, Rafael Kramann, Daniel J. Rader, Peter Libby, Sasha A. Singh, Elena Aikawa
Total citations by year
Citation information
Citations to this article (129)
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The Journal of biological chemistry | 2018 |
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Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks
A Dickhout, RR Koenen |
Frontiers in Cardiovascular Medicine | 2018 |
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Sheep-Specific Immunohistochemical Panel for the Evaluation of Regenerative and Inflammatory Processes in Tissue-Engineered Heart Valves
S Dekker, D van Geemen, AJ van den Bogaerdt, A Driessen-Mol, E Aikawa, AI Smits |
Frontiers in Cardiovascular Medicine | 2018 |
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Highlights From Vascular Discovery: From Genes to Medicine Scientific Sessions 2018
BA Bartolo, AC Straub |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
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S100/RAGE-Mediated Inflammation and Modified Cholesterol Lipoproteins as Mediators of Osteoblastic Differentiation of Vascular Smooth Muscle Cells
B Chellan, NR Sutton, MA Bowman |
Frontiers in Cardiovascular Medicine | 2018 |
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Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism
MC Blaser, E Aikawa |
Frontiers in Cardiovascular Medicine | 2018 |
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Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative StressNovelty and Significance
MA Rogers, N Maldonado, JD Hutcheson, C Goettsch, S Goto, I Yamada, T Faits, H Sesaki, M Aikawa, E Aikawa |
Circulation research | 2017 |
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Extracellular vesicles in coronary artery disease
CM Boulanger, X Loyer, PE Rautou, N Amabile |
Nature Reviews Cardiology | 2017 |
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Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice
J Li, DJ Matye, Y Wang, T Li |
FEBS Letters | 2017 |
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Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease
S Glerup, R Schulz, U Laufs, KD Schlüter |
Basic Research in Cardiology | 2017 |
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Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD
M Haarhaus, V Brandenburg, K Kalantar-Zadeh, P Stenvinkel, P Magnusson |
Nature Reviews Nephrology | 2017 |
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Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus
TJ Oh, CH Ahn, BR Kim, KM Kim, JH Moon, S Lim, KS Park, C Lim, HC Jang, SH Choi |
Cardiovascular Diabetology | 2017 |
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Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in MenHighlights
C Goettsch, H Iwata, JD Hutcheson, CJ ODonnell, R Chapurlat, NR Cook, M Aikawa, P Szulc, E Aikawa |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
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A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis
E Aikawa, P Libby |
Circulation | 2017 |
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Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3 T3-L1 adipocytes
J Li, C Chen, Y Li, DJ Matye, Y Wang, WX Ding, T Li |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 |
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Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field
JD Hutcheson, MC Blaser, E Aikawa |
Circulation research | 2017 |
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In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease
CF van der Ven, PJ Wu, MW Tibbitt, A Mil, JP Sluijter, R Langer, E Aikawa |
Clinical Science | 2017 |
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Extracellular Vesicles as Protagonists of Diabetic Cardiovascular Pathology
D Gustafson, S Veitch, JE Fish |
Frontiers in Cardiovascular Medicine | 2017 |
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Microvesicles in Atherosclerosis and Angiogenesis: From Bench to Bedside and Reverse
L Badimon, R Suades, G Arderiu, E Peña, G Chiva-Blanch, T Padró |
Frontiers in Cardiovascular Medicine | 2017 |
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Extracellular Vesicles As Mediators of Cardiovascular Calcification
AB Nik, JD Hutcheson, E Aikawa |
Frontiers in Cardiovascular Medicine | 2017 |
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Endothelial- and Immune Cell-Derived Extracellular Vesicles in the Regulation of Cardiovascular Health and Disease
F Jansen, Q Li, A Pfeifer, N Werner |
JACC: Basic to Translational Science | 2017 |
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Sortilin and Its Multiple Roles in Cardiovascular and Metabolic DiseasesHighlights
C Goettsch, M Kjolby, E Aikawa |
Arteriosclerosis, thrombosis, and vascular biology | 2017 |
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Imaging Atherosclerotic Plaque Calcification: Translating Biology
G Bailey, J Meadows, AR Morrison |
Current Atherosclerosis Reports | 2016 |
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A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification
C Goettsch, JD Hutcheson, S Hagita, MA Rogers, MD Creager, T Pham, J Choi, AK Mlynarchik, B Pieper, M Kjolby, M Aikawa, E Aikawa |
Atherosclerosis | 2016 |
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Calcification in atherosclerotic lesions:
H Lu, M Sheppard, A Daugherty |
Current Opinion in Lipidology | 2016 |
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Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β ProductionHighlights
N Ceneri, L Zhao, BD Young, A Healy, S Coskun, H Vasavada, TO Yarovinsky, K Ike, R Pardi, L Qin, L Qin, G Tellides, K Hirschi, J Meadows, R Soufer, HJ Chun, MM Sadeghi, JR Bender, AR Morrison |
Arteriosclerosis, thrombosis, and vascular biology | 2016 |
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