(A) In many RP patients, the loss of rod photoreceptors leads to night blindness. Secondary to this effect, there is reduced clearance of ROS, causing increased oxidative stress and nutrient shortage via decreased glucose metabolism in the outer segments. These two factors contribute to cone cell death over time. (B) Since cone cell death occurs slowly, there is a window of opportunity to preserve cone survival and function. The studies by Venkatesh et al. (5) and Xiong et al. (4) demonstrate that constitutive activation of mTORC1 or AAV-mediated NRF2 expression can extend cone survival and preserve cone outer segment morphology and function in mouse models of retinal degeneration. While mTORC1 activation targeted nutrient shortage in the cones by increasing glucose metabolism, NRF2 expression reduced ROS and decreased oxidative stress, thereby preserving cone vision.