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Citations to this article

Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs
Cezmi A. Akdis, Mübeccel Akdis
Cezmi A. Akdis, Mübeccel Akdis
Published November 3, 2014
Citation Information: J Clin Invest. 2014;124(11):4678-4680. https://doi.org/10.1172/JCI78891.
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Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs

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Abstract

During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors, such as IL-10 and TGF-β, the production of IgG4 isotype allergen–specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues.

Authors

Cezmi A. Akdis, Mübeccel Akdis

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