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Usage Information

The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance
Stanley Chun-Wei Lee, Omar Abdel-Wahab
Stanley Chun-Wei Lee, Omar Abdel-Wahab
Published September 17, 2014
Citation Information: J Clin Invest. 2014;124(10):4227-4230. https://doi.org/10.1172/JCI77984.
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Commentary

The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

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Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a disorder of hematopoietic stem cells that has largely been considered a monogenic disorder due to acquisition of mutations in the gene encoding PIGA, which is required for glycosylphosphatidylinositol (GPI) anchor biosynthesis. In this issue of the JCI, Shen et al. discovered that PNH is in fact a complex genetic disorder orchestrated by many genetic alterations in addition to PIGA mutations. Some of these mutations predate the acquisition of PIGA mutations, while others occur later. Surprisingly, this work indicates that PNH has a clonal evolution and architecture strikingly similar to that of other myeloid neoplasms, highlighting a potentially broader mechanism of disease pathogenesis in this disorder.

Authors

Stanley Chun-Wei Lee, Omar Abdel-Wahab

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