Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The role for autophagy in cancer
Eileen White
Eileen White
Published January 2, 2015
Citation Information: J Clin Invest. 2015;125(1):42-46. https://doi.org/10.1172/JCI73941.
View: Text | PDF
Review Article has an altmetric score of 45

The role for autophagy in cancer

  • Text
  • PDF
Abstract

Autophagy is a survival-promoting pathway that captures, degrades, and recycles intracellular proteins and organelles in lysosomes. Autophagy preserves organelle function, prevents the toxic buildup of cellular waste products, and provides substrates to sustain metabolism in starvation. Although in some contexts autophagy suppresses tumorigenesis, in most contexts autophagy facilitates tumorigenesis. Cancers can upregulate autophagy to survive microenvironmental stress and to increase growth and aggressiveness. Mechanisms by which autophagy promotes cancer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic function of mitochondria. Efforts to inhibit autophagy to improve cancer therapy have thereby attracted great interest.

Authors

Eileen White

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2009 Total
Citations: 19 66 59 85 101 102 86 87 70 60 18 1 1 755
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (755)

Title and authors Publication Year
The protective role of baicalin regulation of autophagy in cancers
Zhang Q, Guo S, Ge H, Wang H
Cytotechnology 2025
Identifying Potential Autophagy Modulators in Panch Phoron Spices (P5S): An In Silico approach
Parveen S, Ikhlas S, Faruqui T, Hasan A, Khatoon A, Saeed M, Alkhathami AG, Siddiqui S, Uddin S, Mir SS
ACS Omega 2025
Loss of DDX24 inhibits lung cancer progression by stimulating IKBKG splicing-mediated autophagy
Sun S, Jing X, Tong G, Chen C, Xie S, Wang C, Chen D, Zhao J, Qi Y, Zhang W, Liu C, Zhang G, Zhang J, Sun B, Wang Y, Lv Y
Theranostics 2025
Sustained induction of autophagy enhances survival during prolonged starvation in newt cells
Hasan MM, Goto S, Sekiya R, Hayashi T, Li TS, Kawabata T
Life Science Alliance 2025
Dietary Restrictions and Cancer Prevention: State of the Art
Caprara G, Pallavi R, Sanyal S, Pelicci PG
Nutrients 2025
Hypoxia‐Induced Metabolic and Functional Changes in Oral CSCs: Implications for Stemness and Viability Modulation Through BNIP3‐Driven Mitophagy
Li X, Chaouhan HS, Yu S, Wang I, Yu T, Chuang Y, Chen K, Lin F, Chen MY, Hsu C, Sun K, Li C
Journal of Cellular and Molecular Medicine 2025
Chronic IL-1-Exposed LNCaP Cells Evolve High Basal p62-KEAP1 Complex Accumulation and NRF2/KEAP1-Dependent and -Independent Hypersensitive Nutrient Deprivation Response
Dahl-Wilkie H, Gomez J, Kelley A, Manjit K, Mansoor B, Kanumuri P, Pardo S, Molleur D, Falah R, Konakalla AR, Omiyale M, Weintraub S, Delk NA
Cells 2025
The Role of the Fox Gene in Breast Cancer Progression
Pei S, Zhang D, Li Z, Liu J, Li Z, Chen J, Xie Z
International Journal of Molecular Sciences 2025
Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy
Chou HL, Lin IL, Chen YT, Chang WT, Yu A, Chen WC, Wu CY, Chiou SJ, Shu CW, Chiu CC, Liu PF
Cancer Cell International 2025
Current and future therapies for small cell lung carcinoma
Zhai X, Zhang Z, Chen Y, Wu Y, Zhen C, Liu Y, Lin Y, Chen C
Journal of Hematology & Oncology 2025
The role of autophagy in cancer: from molecular mechanism to therapeutic window
Jalali P, Shahmoradi A, Samii A, Mazloomnejad R, Hatamnejad MR, Saeed A, Namdar A, Salehi Z
Frontiers in Immunology 2025
RNA-binding proteins and autophagy in lung cancer: mechanistic insights and therapeutic perspectives
Lei X, Zheng Y, SU W
Discover Oncology 2025
The role and machine learning analysis of mitochondrial autophagy-related gene expression in lung adenocarcinoma
Wang B, Liu D, Shi D, Li X, Li Y
Frontiers in Immunology 2025
Natural compounds and programmed necrosis: pioneering a new frontier in cancer treatments.
Al Amin M, Bouhenni H, Zehravi M, Sweilam SH, Durgawale TP, Qureshi MS, Durgapal S, Haque MA, Vodeti R, Urs D, Shatu MM, Rab SO, Doukani K, Emran TB
Naunyn-Schmiedeberg's archives of pharmacology 2025
cGAS-STING signaling in melanoma: regulation and therapeutic targeting.
Jiang T, Fei L
Naunyn-Schmiedeberg's archives of pharmacology 2025
Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis.
Wang X, Li S, Lin S, Han Y, Zhan T, Huang Z, Wang J, Li Y, Deng H, Zhang M, Feng D, Ge L
Cell research 2025
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Xu X, Pang Y, Fan X
Signal Transduction and Targeted Therapy 2025
Deciphering the dual role of autophagy in gastric cancer and gastroesophageal junction cancer: from tumor suppression to cancer progression
Lei L, Zhang J, Wei R, Dong B, Wang X, Zhou Y
Discover Oncology 2025
Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer.
McCabe M, Bhattacharyya R, Sereda R, Santiago-Fernández O, Khawaja RR, Diaz A, Lindenau K, Ozturk DG, Garner TP, Sidoli S, Cuervo AM, Gavathiotis E
EMBO molecular medicine 2025
JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells.
Zhao Y, Lin S, Zeng W, Lin X, Qin X, Miu B, Gao S, Wu H, Liu J, Chen X
Journal of Cancer 2024
Evaluation of Beclin1 and mTOR genes and p62 protein expression in breast tumor tissues of Iranian patients.
Adelipour M, Naghashpour M, Roshanazadeh MR, Chenaneh H, Mohammadi A, Pourangi P, Miri SR, Zahedi A, Haghighatnezhad M, Golabi S
Molecular Biology Research Communications 2024
Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer.
Zhou W, Lim A, Edderkaoui M, Osipov A, Wu H, Wang Q, Pandol S
International journal of biological sciences 2024
Molecular basis and current insights of atypical Rho small GTPase in cancer.
Huang H, Wang S, Guan Y, Ren J, Liu X
Molecular Biology Reports 2024
Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy
Shi Y, Wang S, Liu D, Wang Z, Zhu Y, Li J, Xu K, Li F, Wen H, Yang R
Burns & Trauma 2024
Synthesis and Structural Optimization of ATG4B Inhibitors for the Attenuation of Autophagy in Glioblastoma
Kim DR, Orr MJ, Yu X, Munshi HH, Wang A, Trudeau C, Kwong AJ, Cheng SY, Scheidt KA
ACS Medicinal Chemistry Letters 2024
Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer
Yang X, Xiong S, Zhao X, Jin J, Yang X, Du Y, Zhao L, He Z, Gong C, Guo L, Liang T
International journal of molecular sciences 2024
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.
Wang Z, Yan M, Ye L, Zhou Q, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B, Lu Z, Xu D
The EMBO Journal 2024
Transcription factor EB-mediated autophagy affects cell migration and inhibits apoptosis to promote endometriosis.
Chen Q, Zhou Y, Yu M, Zhu S, Sun J, Du W, Chen Z, Tao J, Feng X, Zhang Q, Zhao Y
Apoptosis : an international journal on programmed cell death 2024
Autophagy: a necessary evil in cancer and inflammation.
Mathur A, Ritu, Chandra P, Das A
3 Biotech 2024
Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer
Cancemi G, Caserta S, Gangemi S, Pioggia G, Allegra A
Journal of Clinical Medicine 2024
The Role of Autophagy in Human Uveal Melanoma and the Development of Potential Disease Biomarkers and Novel Therapeutic Paradigms
Wang JZ, Paulus P, Niu Y, Zhu L, Morisseau C, Rawling T, Murray M, Hammock BD, Zhou F
Biomedicines 2024
RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway
Ding X, Li X, Jiang Y, Li Y, Li H, Shang L, Feng G, Zhang H, Xu Z, Yang L, Li B, Zhao RC
Cancer Cell International 2024
The multiple roles of autophagy in uveal melanoma and the microenvironment
Liu B, Yao X, Shang Y, Dai J
Journal of Cancer Research and Clinical Oncology 2024
ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m(6)A-dependent manner.
Wang H, Zhao S, Liu H, Liu Y, Zhang Z, Zhou Z, Wang P, Qi S, Xie J
International journal of biological sciences 2024
Global research and emerging trends in autophagy in lung cancer: a bibliometric and visualized study from 2013 to 2022.
Liu BN, Chen J, Piao Y
Frontiers in pharmacology 2024
Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine
Liu Z, Lu T, Qian R, Wang Z, Qi R, Zhang Z
International Journal of Nanomedicine 2024
Cell Death in Liver Disease and Liver Surgery
Stoess C, Choi YK, Onyuru J, Friess H, Hoffman HM, Hartmann D, Feldstein AE
Biomedicines 2024
YAP1 Regulates the YAP1/AR/PSA Axis through Autophagy in Castration-Resistant Prostate Cancer and Mediates T-Cell Immune and Inflammatory Cytokine Infiltration
Wang Y, Wu N, Li J, Zhou D, Liang J, Cao Q, Guan Z, Xu Y, Jiang N
Biomedicines 2024
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy.
Chen RX, Xu SD, Deng MH, Hao SH, Chen JW, Ma XD, Zhuang WT, Cao JH, Lv YR, Lin JL, Li SY, Qiao GB, Xie D, Wang FW
Signal Transduction and Targeted Therapy 2024
Natural products targeting autophagy and apoptosis in NSCLC: a novel therapeutic strategy
Qin P, Li Q, Zu Q, Dong R, Qi Y
Frontiers in Oncology 2024
IGF2BP2 modulates autophagy and serves as a prognostic marker in glioma
Li N, Deng L, Zhang Y, Tang X, Lei B, Zhang Q
2024
Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway.
Wong MM, Aziz NA, Ch'ng ES, Armon S, Chook JB, Bong JJ, Peh SC, Wu YS, Teow SY
Journal Of Molecular Histology 2024
The multifaceted role of extracellular vesicles (EVs) in colorectal cancer: metastasis, immune suppression, therapy resistance, and autophagy crosstalk
Rahmati S, Moeinafshar A, Rezaei N
Journal of Translational Medicine 2024
Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer
Hong GL, Kim KH, Kim YJ, Lee HJ, Cho SP, Han SY, Yang SW, Lee JS, Kang SK, Lim JS, Jung JY
Biological research 2024
Dynamic Proteomic Changes in Tumor and Immune Organs Reveal Systemic Immune Response to Tumor Development
Li Z, Liu S, Gao Z, Ji L, Jiao J, Zheng N, Li X, Wang G, Qin J, Wang Y
Molecular & cellular proteomics : MCP 2024
Regulation of Cancer-Associated miRNAs Expression under Hypoxic Conditions
Valencia-Cervantes J, Sierra-Vargas MP
Analytical cellular pathology (Amsterdam) 2024
Multifaceted role of TRIM21 in inflammation.
Tanveer S, Afzal A, Gul Z, Afzal H, Noureen A, Sharif M, Khawar MB
2024
Exogenous Metabolic Modulators Improve Response to Carboplatin in Triple-Negative Breast Cancer
Ho AN, Kiesel VA, Gates CE, Brosnan BH, Connelly SP, Glenny EM, Cozzo AJ, Hursting SD, Coleman MF
Cells 2024
The role of chaperone-mediated autophagy in drug resistance
Teixeira AB, Ramalho MC, de Souza I, de Andrade IA, Osawa IY, Guedes CB, de Oliveira BS, de Souza CH Filho, da Silva TL, Moreno NC, Latancia MT, Rocha CR
Genetics and molecular biology 2024
Exploring the Role and Prognostic Value of TMEM208 in Head and Neck Squamous Cell Carcinoma
Yang J, Song T
Asian Pacific Journal of Cancer Prevention 2024
Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy
Liu AB, Liu J, Wang S, Ma L, Zhang JF
Cancer Cell International 2024
Enhancing Therapeutic Efficacy in Cancer Treatment: Integrating Nanomedicine with Autophagy Inhibition Strategies
Walweel N, Aydin O
ACS Omega 2024
NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer
Ling L, Chen J, Zhan L, Fu J, He R, Wang W, Wei B, Ma X, Cao Y
Scientific Reports 2024
The role of Phafin proteins in cell signaling pathways and diseases
Tang T, Sun J, Li C
Open Life Sciences 2024
OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell
Kim YJ, Lee HJ, Kim KH, Cho SP, Jung JY
Discover. Oncology 2024
MiR-200b-3p elevates 5-FU sensitivity in cholangiocarcinoma cells via autophagy inhibition by targeting KLF4
Peng F, He R, Liu Y, Xie Y, Xiong G, Li X, Wang M, Zhao C, Zhang H, Xu S, Qin R
Non-coding RNA Research 2024
Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective
Raza S, Siddiqui JA, Srivastava A, Chattopadhyay N, Sinha RA, Chakravarti B
2024
MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases
Qi J, Li Q, Xin T, Lu Q, Lin J, Zhang Y, Luo H, Zhang F, Xing Y, Wang W, Cui D, Wang M
Autophagy 2024
Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling.
Sun J, Zhang JX, Li MS, Qin MB, Cheng RX, Wu QR, Chen QL, Yang D, Liao C, Liu SQ, Huang JA
World Journal of Gastroenterology 2024
Nutrient vitamins enabled metabolic regulation of ferroptosis via reactive oxygen species biology.
Wu J, Shi Y, Zhou M, Chen M, Ji S, Liu X, Zhou M, Xia R, Zheng X, Wang W
Frontiers in pharmacology 2024
Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy.
Xing Z, Jiang X, Wu Y, Yu Z
Current cancer drug targets 2024
Primary cilia-associated signalling in squamous cell carcinoma of head and neck region
Putnová I, Putnová BM, Hurník P, Štembírek J, Buchtová M, Kolísková P
Frontiers in Oncology 2024
Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity
Huang Y, Luo G, Peng K, Song Y, Wang Y, Zhang H, Li J, Qiu X, Pu M, Liu X, Peng C, Neculai D, Sun Q, Zhou T, Huang P, Liu W
The Journal of Cell Biology 2024
Global Challenges After a Global Challenge: Lessons Learned from the COVID-19 Pandemic.
Yazdanpanah N, Sedikides C, Ochs HD, Camargo CA Jr, Darmstadt GL, Cerda A, Cauda V, Peters GJ, Sellke F, Wong ND, Comini E, Jimeno AR, Glover V, Hatziargyriou N, Vincenot CE, Bordas SPA, Rao IM, Abolhassani H, Gharehpetian GB, Weiskirchen R, Gupta M, Chandel SS, Olusanya BO, Cheson B, Pomponio A, Tanzer M, Myles PS, Ma WX, Bella F, Ghavami S, Moein Moghimi S, Pratico D, Hernandez AM, Martinez-Urbistondo M, Urbistondo DM, Fereshtehnejad SM, Ali I, Kimura S, Wallace Hayes A, Cai W, Ernest CKJ, Thomas S, Rahimi K, Sorooshian A, Schreiber M, Kato K, Luong JHT, Pluchino S, Lozano AM, Seymour JF, Kosik KS, Hofmann SG, McIntyre RS, Perc M, Leemans A, Klein RS, Ogino S, Wlezien C, Perry G, Nieto JJ, Levin L, Klionsky DJ, Mobasher B, Dorigo T, Rezaei N
Advances in experimental medicine and biology 2024
Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma
Wang C, Wang L
Chinese Medical Journal 2024
Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono- or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms.
Eity TA, Bhuia MS, Chowdhury R, Ahmmed S, Salehin Sheikh, Akter R, Islam MT
Journal of tropical medicine 2024
The role of SIRT1 in autophagy and drug resistance: unveiling new targets and potential biomarkers in cancer therapy.
Tang Y, Ju W, Liu Y, Deng Q
Frontiers in pharmacology 2024
Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy
Rajendran P, Renu K, Ali EM, Genena MA, Veeraraghavan V, Sekar R, Sekar AK, Tejavat S, Barik P, Abdallah BM
Immunity, Inflammation and Disease 2024
Nanotechnology-Based Drug Delivery Systems for Treating Acute Kidney Injury
Qin W, Huang J, Zhang M, Xu M, He J, Liu Q
ACS Biomaterials Science & Engineering 2024
Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance
Wang F, Liao Q, Qin Z, Li J, Wei Q, Li M, Deng H, Xiong W, Tan M, Zhou M
Cell Death & Disease 2024
Catharanthine, an anticancer vinca alkaloid: an in silico and in vitro analysis of the autophagic system as the major mechanism of cell death in liver HepG2 cells.
Gholami F, Seyedalipour B, Heidari-Kalvani N, Nabi-Afjadi M, Yaghoubzad-Maleki M, Fathi Z, Alipourfard I, Barjesteh F, Bahreini E
Naunyn-Schmiedeberg's archives of pharmacology 2024
The Function of Autophagy in the Initiation, and Development of Breast Cancer.
Beilankouhi EAV, Valilo M, Dastmalchi N, Teimourian S, Safaralizadeh R
Current medicinal chemistry 2024
Transcription factor EB reprograms branched‐chain amino acid metabolism and promotes pancreatic cancer progression via transcriptional regulation of BCAT1
Wang T, Hu Q, Li B, Fan G, Jing D, Xu J, Hu Y, Dang Q, Ji S, Zhou C, Zhuo Q, Xu X, Qin Y, Yu X, Li Z
Cell Proliferation 2024
NKX3-2 Induces Ovarian Cancer Cell Migration by HDAC6-Mediated Repositioning of Lysosomes and Inhibition of Autophagy
Ferraresi A, Ghezzi I, Salwa A, Esposito A, Dhanasekaran DN, Isidoro C
Cells 2024
ISO-upregulated BECN1 specifically promotes LC3B-dependent autophagy and anticancer activity in invasive bladder cancer
Hua X, Xiang D, Xu J, Zhang S, Wu S, Tian Z, Zhu J, Huang C
Translational Oncology 2024
Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species
Ju S, Singh MK, Han S, Ranbhise J, Ha J, Choe W, Yoon KS, Yeo SG, Kim SS, Kang I
International Journal of Molecular Sciences 2024
Autophagy Involvement in Non-Neoplastic and Neoplastic Endometrial Pathology: The State of the Art with a Focus on Carcinoma
Pizzimenti C, Fiorentino V, Ruggeri C, Franchina M, Ercoli A, Tuccari G, Ieni A
International Journal of Molecular Sciences 2024
结核杆菌抗原85B抑制自噬促进霍奇金淋巴瘤细胞凋亡机制研究
Chinese Journal of Contemporary Pediatrics 2024
Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy
Wang X, Fang L, Xiao L, Zhong G, Han M, Wang B, Ren J, Zang Y
Frontiers in Immunology 2024
Wnt Signaling in Hepatocellular Carcinoma: Biological Mechanisms and Therapeutic Opportunities
Zhu Y, He Y, Gan R
Cells 2024
Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy
Mengistu BA, Tsegaw T, Demessie Y, Getnet K, Bitew AB, Kinde MZ, Beirhun AM, Mebratu AS, Mekasha YT, Feleke MG, Fenta MD
Cancer Cell International 2024
Autophagy and cancer therapy
Pimentel JM, Zhou JY, Wu GS
Cancer letters 2024
TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway
Lei J, Zhu Q, Guo J, Chen J, Qi L, Cui M, Jiang Z, Fan C, Wang L, Lai T, Jin Y, Si L, Liu Y, Yang Q, Bao D, Guo R
Journal of Translational Medicine 2024
BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons
Jin Y, Zhao L, Zhang Y, Chen T, Shi H, Sun H, Ding S, Chen S, Cao H, Zhang G, Li Q, Gao J, Xiao M, Sheng C
Autophagy 2024
Exosomes derived from cancer-associated fibrolasts mediated ciplatin resistance
Meng Y, Shao H, Wu L
CytoJournal 2024
DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis.
Yu W, Ma L, Li X
Oncology reports 2023
The role of autophagy in viral infections.
Chen T, Tu S, Ding L, Jin M, Chen H, Zhou H
Journal of biomedical science 2023
Fluoride in the Central Nervous System and Its Potential Influence on the Development and Invasiveness of Brain Tumours-A Research Hypothesis.
Żwierełło W, Maruszewska A, Skórka-Majewicz M, Gutowska I
International journal of molecular sciences 2023
Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules.
Martins-Gomes C, Nunes FM, Silva AM
International journal of molecular sciences 2023
Autophagy Paradox: Strategizing Treatment Modality in Melanoma
Pangilinan C, Xu X, Herlyn M, Liang C
Current Treatment Options in Oncology 2023
A novel antimicrobial peptide M1‐8 targets the lysosomal pathway to inhibit autolysosome formation and promote apoptosis in liver cancer cells
Zeng J, Wang J, Wu J, Deng R, Zhang L, Chen Q, Wang J, Jin X, Gui S, Xu Y, Lu X
Journal of Cellular and Molecular Medicine 2023
Solanine Represses Gastric Cancer Growth by Mediating Autophagy Through AAMDC/MYC/ATF4/Sesn2 Signaling Pathway
Tang X, Guo Y, Zhang S, Wang X, Teng Y, Jin Q, Jin Q, Shen W, Wang R
Drug design, development and therapy 2023
An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma
Ren Y, Da J, Ren J, Song Y, Han J
BMC oral health 2023
Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction.
Kim B, Gwak J, Kim M, Yang S, Hwang S, Shin S, Kim JH, Son J, Jeong SM
Cancer Gene Therapy 2023
Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling.
Yang F, Kalantari S, Ruan B, Sun S, Bian Z, Guan JL
Nature Communications 2023
Identification of an Autophagy-Related Signature for Prognosis and Immunotherapy Response Prediction in Ovarian Cancer.
Ding J, Wang C, Sun Y, Guo J, Liu S, Cheng Z
Biomolecules 2023
Protein homeostasis in aging and cancer
Chen XQ, Shen T, Fang SJ, Sun XM, Li GY, Li YF
Frontiers in Cell and Developmental Biology 2023
Hydroalcoholic extract of Buxus sempervirens shows antiproliferative effect on melanoma, colorectal carcinoma and prostate cancer cells by affecting the autophagic flow
Volpe AR, Carmignani M, Cesare P
Frontiers in pharmacology 2023
Where is the field of autophagy research heading?
Abeliovich H, Debnath J, Ding WX, Jackson WT, Kim DH, Klionsky DJ, Ktistakis N, Margeta M, Münz C, Petersen M, Sadoshima J, Vergne I
Autophagy 2023
Carcinogenic Effects of Areca Nut and Its Metabolites: A Review of the Experimental Evidence.
Senevirathna K, Pradeep R, Jayasinghe YA, Jayawickrama SM, Illeperuma R, Warnakulasuriya S, Jayasinghe RD
Clinics and Practice 2023
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms.
Altabbal S, Athamnah K, Rahma A, Wali AF, Eid AH, Iratni R, Al Dhaheri Y
Pharmaceuticals (Basel, Switzerland) 2023
PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy
Liu Y, Wu M, Xu S, Niu X, Liu W, Miao C, Lin A, Xu Y, Yu L
Cell & Bioscience 2023
A new glance at autophagolysosomal-dependent or -independent function of transcriptional factor EB in human cancer.
Wang T, Qin Y, Ye Z, Jing DS, Fan GX, Liu MQ, Zhuo QF, Ji SR, Chen XM, Yu XJ, Xu XW, Li Z
Acta Pharmacologica Sinica 2023
Targeting mTOR for Anti-Aging and Anti-Cancer Therapy
Fu W, Wu G
Molecules (Basel, Switzerland) 2023
The crosstalk between autophagy and myeloid-derived suppressor cell responses in cancer.
Nie J, Wang D, Li M
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023
Impact of context-dependent autophagy states on tumor progression.
Assi M, Kimmelman AC
Nature cancer 2023
Temozolomide Resistance in Glioblastoma by NRF2: Protecting the Evil
Almeida Lima K, Osawa IY, Ramalho MC, de Souza I, Guedes CB, de Souza Filho CH, Monteiro LK, Latancia MT, Rocha CR
Biomedicines 2023
Reviewing the Prospective Pharmacological Potential of Isothiocyanates in Fight against Female-Specific Cancers
Shoaib S, Khan FB, Alsharif MA, Malik MS, Ahmed SA, Jamous YF, Uddin S, Tan CS, Ardianto C, Tufail S, Ming LC, Yusuf N, Islam N
Cancers 2023
Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation
Broadbent DG, Barnaba C, Perez GI, Schmidt JC
The Journal of Cell Biology 2023
Delineating the twin role of autophagy in lung cancer.
Zhang S, Qian Y, Ye L
2023
An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?
Teraiya M, Perreault H, Chen VC
Frontiers in Oncology 2023
Autophagy in the pharmacological activities of celastrol (Review)
Zhang C, Wang W, Du C, Li H, Zhou K, Luan Z, Chang Y, Liu S, Wei Y
Experimental and therapeutic medicine 2023
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer
Hui Wang, Yingkuan Liang, Te Zhang, Xinnian Yu, Xuming Song, Yuzhong Chen, Qixing Mao, Wenjie Xia, Bing Chen, Lin Xu, Gaochao Dong, Feng Jiang
Cell Death and Differentiation 2023
HRD1 promotes non-small cell lung carcinoma metastasis by blocking autophagy-mediated MIEN1 degradation.
Zeng C, Guo J, Wu J, Che T, Huang X, Liu H, Lin Z
The Journal of biological chemistry 2023
Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill.
Tian Y, Ma B, Yu S, Li Y, Pei H, Tian S, Zhao X, Liu C, Zuo Z, Wang Z
Chinese Herbal Medicines 2023
Autophagy: A challengeable paradox in cancer treatment
Ahmadi\u2010Dehlaghi F, Mohammadi P, Valipour E, Pournaghi P, Kiani S, Mansouri K
Cancer Medicine 2023
MFAP2 enhances cisplatin resistance in gastric cancer cells by regulating autophagy.
Li M, Zhang HY, Zhang RG
PeerJ 2023
Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention
Jin D, Huang NN, Wei JX
Frontiers in pharmacology 2023
Stromal cell‐derived small extracellular vesicles enhance radioresistance of prostate cancer cells via interleukin‐8‐induced autophagy
Wang X, Xu F, Kou H, Zheng Y, Yang J, Xu Z, Fang Y, Sun W, Zhu S, Jiang Q, Wei X, Xu Y
Journal of Extracellular Vesicles 2023
Update on Autophagy Inhibitors in Cancer: Opening up to a Therapeutic Combination with Immune Checkpoint Inhibitors
Bestion E, Raymond E, Mezouar S, Halfon P
Cells 2023
AKR7A3 modulates the metastasis of pancreatic ductal adenocarcinoma through regulating PHGDH‐suppressed autophagy
Hua L, Song Y, Min J, Wang R, Li H, Zhu L, Guo Y, Gan D, Li S, Ma P, Yang C, Yang J, Shi J, Li J, Su H
Cancer Science 2023
An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer.
Zhang X, Shan G, Li N, Chen J, Ji C, Li X, Jiang L, Lee TKW, Keng VW, Zhao Y
Cell Death Discovery 2023
ATG16L1 and ATG12 Gene Polymorphisms Are Involved in the Progression of Atrophic Gastritis
Yamaguchi N, Sakaguchi T, Isomoto H, Inamine T, Ueda H, Fukuda D, Ohnita K, Kanda T, Kurumi H, Matsushima K, Hirayama T, Yashima K, Tsukamoto K
Journal of Clinical Medicine 2023
BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma.
Wang J, Chen A, Xue Z, Liu J, He Y, Liu G, Zhao Z, Li W, Zhang Q, Chen A, Wang J, Li X, Wang X, Huang B
Cell Death and Disease 2023
The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.
Delorme-Axford E, Wen X, Klionsky DJ
Autophagy 2023
TNFSF10, an autophagy related gene, was a prognostic and immune infiltration marker in skin cutaneous melanoma
Xue L, Zhang W, Ju Y, Xu X, Bo H, Zhong X, Hu Z, Zheng C, Fang B, Tang S
Journal of Cancer 2023
Mechanisms of exercise in the treatment of lung cancer – a mini-review
Luo Z, Wan R, Liu S, Feng X, Peng Z, Wang Q, Chen S, Shang X
Frontiers in immunology 2023
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway.
Wang HL, Li JN, Kan WJ, Xu GY, Luo GH, Song N, Wu WB, Feng B, Fu JF, Tu YT, Liu MM, Xu R, Zhou YB, Wei G, Li J
Acta Pharmacologica Sinica 2023
Inhibition of Dipeptidyl Peptidase-4 Activates Autophagy to Promote Survival of Breast Cancer Cells via the mTOR/HIF-1α Pathway
Kawakita E, Yang F, Shi S, Takagaki Y, Koya D, Kanasaki K
Cancers 2023
The Current Status of the Liver Liquid Biopsy in MASH Related HCC: Overview and Future Directions
Ugonabo O, Udoh UA, Rajan PK, Reeves H, Arcand C, Nakafuku Y, Joshi T, Finley R, Pierre SV, Sanabria JR
Biomolecules 2023
The Crosstalk Between Autophagy and MicroRNAs in Esophageal Carcinoma: -
Gorjizadeh N, poudineh S, Barghgir B, Eghbali M, Sarlak A, poudineh M
Galen medical journal 2023
Ferroptosis, autophagy, tumor and immunity
Xie Y, Zhou Y, Wang J, Du L, Ren Y, Liu F
Heliyon 2023
Updating the therapeutic role of ginsenosides in breast cancer: a bibliometrics study to an in-depth review
Deng X, Wang J, Lu C, Zhou Y, Shen L, Ge A, Fan H, Liu L
Frontiers in pharmacology 2023
The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress
Seo G, Yu C, Han H, Xing L, Kattan RE, An J, Kizhedathu A, Yang B, Luo A, Buckle AL, Tifrea D, Edwards R, Huang L, Ju HQ, Wang W
Molecular Cell 2023
Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma
Rajan PK, Udoh UA, Nakafuku Y, Pierre SV, Sanabria J
Cells 2023
Genetic assessment of pathogenic germline alterations in lysosomal genes among Asian patients with pancreatic ductal adenocarcinoma
Koh Y, Kim H, Joo SY, Song S, Choi YH, Kim HR, Moon B, Byun J, Hong J, Shin DY, Park S, Lee KH, Lee KT, Lee JK, Park D, Lee SH, Jang JY, Lee H, Kim JA, Yoon SS, Park JK
Journal of Translational Medicine 2023
Mechanisms and effects of metformin on skeletal muscle disorders
Shang R, Miao J
Frontiers in neurology 2023
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration
Liang P, Zhang J, Wu Y, Zheng S, Xu Z, Yang S, Wang J, Ma S, Xiao L, Hu T, Jiang W, Huang C, Xing Q, Kundu M, Wang B
EMBO reports 2023
CPT1A mediates chemoresistance in human hypopharyngeal squamous cell carcinoma via ATG16L1-dependent cellular autophagy
Sun L, Wang X, Chen L, Gao Z, Xu S, Hu C, Fan G, Wang B, Feng T, Wang W, Ying X
2023
The Role of Bcl-2 and Beclin-1 Complex in “Switching” between Apoptosis and Autophagy in Human Glioma Cells upon LY294002 and Sorafenib Treatment
Zając A, Maciejczyk A, Sumorek-Wiadro J, Filipek K, Deryło K, Langner E, Pawelec J, Wasiak M, Ścibiorski M, Rzeski W, Tchórzewski M, Reichert M, Jakubowicz-Gil J
Cells 2023
MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma
Meng L, Gao J, Mo W, Wang B, Shen H, Cao W, Ding M, Diao W, Chen W, Zhang Q, Shu J, Dai H, Guo H
Redox Biology 2023
CCL2 promotes metastasis and epithelial–mesenchymal transition of non‐small cell lung cancer via PI3K/Akt/mTOR and autophagy pathways
Xu H, Wang J, Al\u2010Nusaif M, Ma H, Le W
Cell Proliferation 2023
Crosstalk between the mTOR pathway and primary cilia in human diseases
Prosseda PP, Prosseda SD, Tran M, Liton PB, Sun Y
Current topics in developmental biology 2023
Repressing IRS1/2 by NT157 inhibits the malignant behaviors of ovarian cancer through inactivating PI3K/AKT/mTOR pathway and inducing autophagy
Li C, Men C, Yang W, Chen R, Zhu J, Cheng Z
The Kaohsiung Journal of Medical Sciences 2023
AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression
L Wan, R Jia, L Ji, X Qin, L Hu, F Hu, Y Han, Y Pan, C Jiang, W Liu
Journal of Neuroinflammation 2022
Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment
L Si, Z Yang, L Ding, D Zhang
Journal of Cancer Research and Clinical Oncology 2022
Insight of Autophagy in Spontaneous Miscarriage
X Qin, H Shen, W Zhou, J Mei, H Lu, X Tan, R Zhu, W Zhou, D Li, T Zhang, J Ye, M Li
International journal of biological sciences 2022
Human Papillomavirus Type 16 Early Protein E7 Activates Autophagy through Inhibition of Dual-Specificity Phosphatase 5
C Hua, Q Zheng, J Zhu, S Chen, Y Song, S van der Veen, H Cheng, N Krasteva
Oxidative Medicine & Cellular Longevity 2022
Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives
S Eltayeb, G Ciarimboli, K Beul, G Marco, V Barz
International journal of molecular sciences 2022
Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox
Hasan A, Rizvi SF, Parveen S, Pathak N, Nazir A, Mir SS
Frontiers in Oncology 2022
The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence
Zhu W, Feng D, Shi X, Wei Q, Yang L
Frontiers in Cell and Developmental Biology 2022
Autophagy regulation by RNA alternative splicing and implications in human diseases
González-Rodríguez P, Klionsky DJ, Joseph B
Nature Communications 2022
Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms
Zhao H, Han B, Li X, Sun C, Zhai Y, Li M, Jiang M, Zhang W, Liang Y, Kai G
Frontiers in pharmacology 2022
Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62
Greer SU, Chen J, Ogmundsdottir MH, Ayala C, Lau BT, Delacruz RG, Sandoval IT, Kristjansdottir S, Jones DA, Haslem DS, Romero R, Fulde G, Bell JM, Jonasson JG, Steingrimsson E, Ji HP, Nadauld LD
Scientific Reports 2022
Isolation of Autophagy Competent Lysosomes from Cancer Cells by Differential Large-Scale Multilayered Density Gradient Centrifugations.
Kacal M, Vakifahmetoglu-Norberg H
Methods in molecular biology (Clifton, N.J.) 2022
Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose.
Frapporti G, Colombo E, Ahmed H, Assoni G, Polito L, Randazzo P, Arosio D, Seneci P, Piccoli G
Pharmaceutics 2022
Estrogen-Induced Extracellular Calcium Influx Promotes Endometrial Cancer Progress by Regulating Lysosomal Activity and Mitochondrial ROS.
Shen B, Hao J, Lin Y, Li X, Yang X, Huang T, Wang J, Jia Y, Zhou J, Wang J
Frontiers in Medicine 2022
FOXK2 promotes the proliferation of papillary thyroid cancer cell by down-regulating autophagy
Li S, Wang P, Ju H, Zhu T, Shi J, Huang Y
Journal of Cancer 2022
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
Zhang S, Peng X, Yang S, Li X, Huang M, Wei S, Liu J, He G, Zheng H, Yang L, Li H, Fan Q
Cell Death and Disease 2022
p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets
Rahman MA, Park MN, Rahman MH, Rashid MM, Islam R, Uddin MJ, Hannan MA, Kim B
Frontiers in Cell and Developmental Biology 2022
Autophagy related long non-coding RNA and breast cancer prognosis analysis and prognostic risk model establishment
Luo Z, Nong B, Ma Y, Fang D
Annals of translational medicine 2022
Construction and Validation of a Prognostic Risk Model for Triple-Negative Breast Cancer Based on Autophagy-Related Genes
Yan C, Liu Q, Jia R
Frontiers in Oncology 2022
The Bright and the Dark Side of TGF-β Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications
Gungor MZ, Uysal M, Senturk S
Cancers 2022
PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage
Brunelli F, Torosantucci L, Gelmetti V, Franzone D, Grünewald A, Krüger R, Arena G, Valente EM
Cells 2022
CARM1 promotes gastric cancer progression by regulating TFE3 mediated autophagy enhancement through the cytoplasmic AMPK-mTOR and nuclear AMPK-CARM1-TFE3 signaling pathways.
Yang S, Zhang J, Chen D, Cao J, Zheng Y, Han Y, Jin Y, Wang S, Wang T, Ma L, Luo T, Wang Y, Qin W, Dong L
Cancer Cell International 2022
Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling.
Zhu T, Zhang H, Li S, Wu K, Yin Y, Zhang X
Experimental & molecular medicine 2022
Survival of HT29 cancer cells is influenced by hepatocyte growth factor receptor inhibition through modulation of self-DNA-triggered TLR9-dependent autophagy response.
Bohusné Barta B, Simon Á, Nagy L, Dankó T, Raffay RE, Petővári G, Zsiros V, Sebestyén A, Sipos F, Műzes G
PloS one 2022
Identification of Prognostic Biomarkers in Patients With Malignant Rhabdoid Tumor of the Kidney Based on mTORC1 Signaling Pathway-Related Genes.
Zhanghuang C, Yao Z, Tang H, Zhang K, Wu C, Li L, Xie Y, Yang Z, Yan B
Frontiers in Molecular Biosciences 2022
SIRT1 regulates mitotic catastrophe via autophagy and BubR1 signaling.
Zhao W, Wang Q, Li L, Xie C, Wu Y, Gautam M, Li L
Molecular and Cellular Biochemistry 2022
Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway
Li T, Tang Z, Li C, Liu X, Cheng L, Yang Z, Zhu X, Liu W, Huang Y
Frontiers in pharmacology 2022
Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway
Xie X, Hu L, Liu L, Wang J, Liu Y, Ma L, Sun G, Li C, Aisa HA, Meng S
Translational oncology 2022
USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model.
Kwon J, Choi H, Ware AD, Morillo BC, Wang H, Bouker KB, Lu X, Waldman T, Han C
Oncogene 2022
The nociceptin receptor promotes autophagy through NF-kB signaling and is transcriptionally regulated by E2F1 in HCC
Zhou X, Chen D, Yan Y, Li Q, Xing W, Liu Y, Chen Y, Wang D, Yuan Y, Xie J, Zeng W, Pan J
Cell Death Discovery 2022
Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival.
Yan RL, Luan CL, Liao CC, Liu LH, Chen FY, Chen HY, Chen RH
Journal of biomedical science 2022
Diclofenac: A Nonsteroidal Anti-Inflammatory Drug Inducing Cancer Cell Death by Inhibiting Microtubule Polymerization and Autophagy Flux
Choi S, Kim S, Park J, Lee SE, Kim C, Kang D
Antioxidants 2022
Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response
Sipos F, Bohusné Barta B, Simon Á, Nagy L, Dankó T, Raffay RE, Petővári G, Zsiros V, Wichmann B, Sebestyén A, Műzes G
2022
The role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker
Jung KT, Oh SH
Experimental & molecular medicine 2022
A novel signature based on autophagy-related lncRNA for prognostic prediction and candidate drugs for lung adenocarcinoma
Gong Z, Li Q, Li J, Xie J, Wang W
Translational cancer research 2022
Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress
Chipurupalli S, Ganesan R, Martini G, Mele L, Reggio A, Esposito M, Kannan E, Namasivayam V, Grumati P, Desiderio V, Robinson N
Cell Death and Disease 2022
Mechanism of cancer stemness maintenance in human liver cancer
Liang N, Yang T, Huang Q, Yu P, Liu C, Chen L, Wang Q, Wang G, He X
Cell Death and Disease 2022
Liquid-liquid phase separation drives cellular function and dysfunction in cancer.
Mehta S, Zhang J
Nature reviews. Cancer 2022
lncRNA H19 promotes glioblastoma multiforme development by activating autophagy by sponging miR-491-5p.
Wang G, Lin X, Han H, Zhang H, Li X, Feng M, Jiang C
Bioengineered 2022
ILP-2: A New Bane and Therapeutic Target for Human Cancers
Zhang Z, Xiang S, Cui R, Peng H, Mridul R, Xiang M
Frontiers in Oncology 2022
Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells
He Y, Li Y, Liang T, Mo S, Liao Y, Chen Z, Zhao S, Ran Q, Han C, Hoa PT
Journal of Gastrointestinal Oncology 2022
Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1α/TGF-β1/SMAD pathway
Shi Y, Wang S, Zhang W, Zhu Y, Fan Z, Huang Y, Li F, Yang R
Stem Cell Research & Therapy 2022
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis
Yang Y, Zhu Y, Zhou S, Tang P, Xu R, Zhang Y, Wei D, Wen J, Thorne RF, Zhang XD, Guan J, Liu L, Wu M, Chen S
The EMBO Journal 2022
Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions
Erfanparast L, Taghizadieh M, Shekarchi AA
Frontiers in Oncology 2022
A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer
Molero-Valenzuela A, Fontova P, Alonso-Carrillo D, Carreira-Barral I, Torres AA, García-Valverde M, Benítez-García C, Pérez-Tomás R, Quesada R, Soto-Cerrato V
Cancers 2022
Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets.
Asgharian P, Tazekand AP, Hosseini K, Forouhandeh H, Ghasemnejad T, Ranjbar M, Hasan M, Kumar M, Beirami SM, Tarhriz V, Soofiyani SR, Kozhamzharova L, Sharifi-Rad J, Calina D, Cho WC
Cancer Cell International 2022
Deacetylation of ATG4B promotes autophagy initiation under starvation
Sun L, Xiong H, Chen L, Dai X, Yan X, Wu Y, Yang M, Shan M, Li T, Yao J, Jiang W, He H, He F, Lian J
Science Advances 2022
Protective Effect of Escitalopram on Hepatocellular Carcinoma by Inducing Autophagy
Chen LJ, Hsu TC, Chan HL, Lin CF, Huang JY, Stewart R, Tzang BS, Chen VC
International journal of molecular sciences 2022
Overview of Research into mTOR Inhibitors
Mao B, Zhang Q, Ma L, Zhao DS, Zhao P, Yan P
Molecules (Basel, Switzerland) 2022
Autophagy-related prognostic signature characterizes tumor microenvironment and predicts response to ferroptosis in gastric cancer.
Li H, Xu B, Du J, Wu Y, Shao F, Gao Y, Zhang P, Zhou J, Tong X, Wang Y, Li Y
Frontiers in Oncology 2022
Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy
Brown H, Chung M, Üffing A, Batistatou N, Tsang T, Doskocil S, Mao W, Willbold D, Bast RC Jr, Lu Z, Weiergräber OH, Kritzer JA
Journal of the American Chemical Society 2022
The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up.
Shim MS, Liton PB
Progress in Retinal and Eye Research 2022
Role of the JNK Pathway in Bladder Cancer.
Lee EH, Kim HT, Chun SY, Chung JW, Choi SH, Lee JN, Kim BS, Yoo ES, Kwon TG, Kim TH, Ha YS
OncoTargets and therapy 2022
Targeting the Metabolic Rewiring in Pancreatic Cancer and Its Tumor Microenvironment
Yamamoto K, Iwadate D, Kato H, Nakai Y, Tateishi K, Fujishiro M
Cancers 2022
Establishment and validation of individualized clinical prognostic markers for LUAD patients based on autophagy-related genes
Fei Y, Xu J, Ge L, Chen L, Yu H, Pan L, Chen P
Aging 2022
The role of lncRNA H19 in tumorigenesis and drug resistance of human Cancers
Zhang X, Luo M, Zhang J, Guo B, Singh S, Lin X, Xiong H, Ju S, Wang L, Zhou Y, Zhou J
Frontiers in Genetics 2022
Influence of nitric oxide signaling mechanisms in cancer
Ramírez-Patiño R, Avalos-Navarro G, Figuera L, Varela-Hernández J, Bautista-Herrera L, Muñoz-Valle J, Gallegos-Arreola M
International journal of immunopathology and pharmacology 2022
The Role of Autophagy in Childhood Central Nervous System Tumors.
Wang Y, Xu Y, Zhu C
Current Treatment Options in Oncology 2022
Adipokines as Regulators of Autophagy in Obesity-Linked Cancer.
García-Miranda A, Garcia-Hernandez A, Castañeda-Saucedo E, Navarro-Tito N, Maycotte P
Cells 2022
Targeting Both Autophagy and Immunotherapy in Breast Cancer Treatment.
Giannopoulos S, Bozkus CC, Zografos E, Athanasiou A, Bongiovanni AM, Doulaveris G, Bakoyiannis CN, Theodoropoulos GE, Zografos GC, Witkin SS, Orfanelli T
Metabolites 2022
Metabolic Reprogramming and Lipophagy Mediates Survival of Ascites Derived Metastatic Ovarian Cancer Cells.
S SK, N Swamy S, Devaraj VR, Premalatha CS, Pallavi VR, Sagar BC, Shinde DD, Gawari R
Asian Pacific Journal of Cancer Prevention 2022
Exosome-encapsulated ncRNAs: Emerging yin and yang of tumor hallmarks.
Khan N, Umar MS, Haq M, Rauf T, Zubair S, Owais M
Frontiers in Genetics 2022
Redox balance and autophagy regulation in cancer progression and their therapeutic perspective.
Khan SU, Fatima K, Aisha S, Hamza B, Malik F
Medical Oncology 2022
A Seven-Autophagy-Related Long Non-Coding RNA Signature Can Accurately Predict the Prognosis of Patients with Renal Cell Carcinoma
Du R, Xiao Q, Huang J, Feng W, Zheng X, Yi T
International journal of general medicine 2022
ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction.
González-Rodríguez P, Cheray M, Keane L, Engskog-Vlachos P, Joseph B
Autophagy 2022
Study on the multitarget mechanism of alliin activating autophagy based on network pharmacology and molecular docking.
Cheng B, Li T, Li F
Journal of Cellular and Molecular Medicine 2022
Dieckol Inhibits Autophagic Flux and Induces Apoptotic Cell Death in A375 Human Melanoma Cells via Lysosomal Dysfunction and Mitochondrial Membrane Impairment
Jo MH, Kim YT, Park SJ
International journal of molecular sciences 2022
Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress.
Catapano J, Luty M, Wróbel T, Pudełek M, Piwowarczyk K, Kędracka-Krok S, Siedlar M, Madeja Z, Czyż J
Cellular & Molecular Biology Letters 2022
Inactivation of Autophagy in Keratinocytes Reduces Tumor Growth in Mouse Models of Epithelial Skin Cancer
Barresi C, Rossiter H, Buchberger M, Pammer J, Sukseree S, Sibilia M, Tschachler E, Eckhart L
Cells 2022
The lysosome as a novel therapeutic target of EGFR-mediated tumor inflammation
Sung WJ, Kim D, Zhu A, Cho N, Yoo HM, Noh JH, Kim KM, Lee HS, Hong J
Frontiers in pharmacology 2022
Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy
Yang H, Xu S, Tang L, Gong J, Fang H, Wei J, Su D
Frontiers in pharmacology 2022
Proton-coupled monocarboxylate transporters in cancer: From metabolic crosstalk, immunosuppression and anti-apoptosis to clinical applications
Duan Q, Zhang S, Wang Y, Lu D, Sun Y, Wu Y
Frontiers in Cell and Developmental Biology 2022
Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy
Alam R, Kabir MF, Kim HR, Chae HJ
Cells 2022
USP5-Beclin 1 axis overrides p53-dependent senescence and drives Kras-induced tumorigenicity.
Li J, Wang Y, Luo Y, Liu Y, Yi Y, Li J, Pan Y, Li W, You W, Hu Q, Zhao Z, Zhang Y, Cao Y, Zhang L, Yuan J, Xiao ZJ
Nature Communications 2022
Purvalanol A induces apoptosis and reverses cisplatin resistance in ovarian cancer
Zhang X, Hong S, Yang J, Liu J, Wang Y, Peng J, Wang H, Hong L
Anti-Cancer Drugs 2022
Co-Targeting the EGFR and PI3K/Akt Pathway to Overcome Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma: What about Autophagy?
Zaryouh H, Van Loenhout J, Peeters M, Vermorken JB, Lardon F, Wouters A
Cancers 2022
Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases
Lashgari NA, Roudsari NM, Zadeh SS, Momtaz S, Abbasifard M, Reiner Ž, Abdolghaffari AH, Sahebkar A
InflammoPharmacology 2022
One-Carbon and Polyamine Metabolism as Cancer Therapy Targets.
Islam A, Shaukat Z, Hussain R, Gregory SL
Biomolecules 2022
FUT2 Facilitates Autophagy and Suppresses Apoptosis via p53 and JNK Signaling in Lung Adenocarcinoma Cells.
Zhang Y, Yao E, Liu Y, Zhang Y, Ding M, Liu J, Chen X, Fan S
Cells 2022
Autophagy-Related ncRNAs in Pancreatic Cancer.
Donati S, Aurilia C, Palmini G, Falsetti I, Iantomasi T, Brandi ML
Pharmaceuticals (Basel, Switzerland) 2022
Inhibition of bromodomain-containing protein 4 enhances the migration of esophageal squamous cell carcinoma cells by inducing cell autophagy.
Yang WQ, Liang R, Gao MQ, Liu YZ, Qi B, Zhao BS
World journal of gastrointestinal oncology 2022
An autophagy-related long non-coding RNA prognostic model and related immune research for female breast cancer
Chen J, Li X, Yan S, Li J, Zhou Y, Wu M, Ding J, Yang J, Yuan Y, Zhu Y, Wu W
Frontiers in Oncology 2022
Role of autophagy in aging: The good, the bad, and the ugly
Tabibzadeh S
Aging Cell 2022
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2022
Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region
Yi F, Cai C, Ruan B, Hao M, Yeo SK, Haas M, Yang F, Zhang X, Guan JL
Autophagy 2022
Dichotomous role of autophagy in cancer
Arif A, Khawar MB, Mehmood R, Abbasi MH, Sheikh N
2022
Autophagy in major human diseases
DJ Klionsky, G Petroni, RK Amaravadi, EH Baehrecke, A Ballabio, P Boya, JM Pedro, K Cadwell, F Cecconi, AM Choi, ME Choi, CT Chu, P Codogno, MI Colombo, AM Cuervo, V Deretic, I Dikic, Z Elazar, EL Eskelinen, GM Fimia, DA Gewirtz, DR Green, M Hansen, M Jäättelä, T Johansen, G Juhász, V Karantza, C Kraft, G Kroemer, NT Ktistakis, S Kumar, C LopezOtin, KF Macleod, F Madeo, J Martinez, A Meléndez, N Mizushima, C Münz, JM Penninger, RM Perera, M Piacentini, F Reggiori, DC Rubinsztein, KM Ryan, J Sadoshima, L Santambrogio, L Scorrano, HU Simon, AK Simon, A Simonsen, A Stolz, N Tavernarakis, SA Tooze, T Yoshimori, J Yuan, Z Yue, Q Zhong, L Galluzzi, F Pietrocola
The EMBO Journal 2021
Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms
Y Yung, E Lee, HT Chu, PK Yip, H Gill
International journal of molecular sciences 2021
Transcriptional coregualtor NUPR1 maintains tamoxifen resistance in breast cancer cells
L Wang, J Sun, Y Yin, Y Sun, J Ma, R Zhou, X Chang, D Li, Z Yao, S Tian, K Zhang, Z Liu, Z Ma
Cell Death and Disease 2021
Autophagy Paradox of Cancer: Role, Regulation, and Duality
AK Verma, PS Bharti, S Rafat, D Bhatt, Y Goyal, KK Pandey, S Ranjan, SA Almatroodi, MA Alsahli, AH Rahmani, A Almatroudi, K Dev, MC Albertini
Oxidative Medicine & Cellular Longevity 2021
The functions of autophagy at the tumour‐immune interface
X Luo, Y Qiu, P Dinesh, W Gong, L Jiang, X Feng, J Li, Y Jiang, YL Lei, Q Chen
Journal of Cellular and Molecular Medicine 2021
Systems Medicine Design for Triple-Negative Breast Cancer and Non-Triple-Negative Breast Cancer Based on Systems Identification and Carcinogenic Mechanisms
SJ Yeh, BJ Hsu, BS Chen
International journal of molecular sciences 2021
p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation
A Nowosad, J Creff, P Jeannot, R Culerrier, P Codogno, S Manenti, L Nguyen, A Besson
Cell Death and Disease 2021
Autophagy: A Friend or Foe in Allergic Asthma?
E Theofani, G Xanthou
International journal of molecular sciences 2021
Advances in the role of autophagy in the development of retinoblastoma (Review)
T Wan, M Fu, Z Wu, X Gao, S Zhou
Oncology Letters 2021
A Perspective on the Role of Autophagy in Cancer
AR Ariosa, V Lahiri, Y Lei, Y Yang, Z Yin, Z Zhang, DJ Klionsky
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2021
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
J Liu, S Li, X Fei, , Y Shen, H Xiu, SA Cormier, C Lu, C Guo, S Wang, Z Cai, P Wang
Autophagy 2021
LC3A-mediated autophagy regulates lung cancer cell plasticity
CC Miao, W Hwang, LY Chu, LH Yang, CT Ha, PY Chen, MH Kuo, SC Lin, YY Yang, SE Chuang, CC Yu, ST Pan, MC Kao, CR Chang, YT Chou
Autophagy 2021
Autophagy and the Lysosomal System in Cancer
S Kumar, M Sánchez-Álvarez, FN Lolo, F Trionfetti, R Strippoli, M Cordani
Cells 2021
CDK4, CDK6/cyclin-D1 Complex Inhibition and Radiotherapy for Cancer Control: A Role for Autophagy
V Nardone, M Barbarino, A Angrisani, P Correale, P Pastina, S Cappabianca, A Reginelli, L Mutti, C Miracco, R Giannicola, A Giordano, L Pirtoli
International journal of molecular sciences 2021
Moments in autophagy and disease: Past and present
X Wen, Y Yang, DJ Klionsky
Molecular Aspects of Medicine 2021
Small Molecules Targeting Programmed Cell Death in Breast Cancer Cells
S Maniam, S Maniam
International journal of molecular sciences 2021
Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib
Y Liu, Y Du
Technology in cancer research & treatment 2021
Protein clearance strategies for disease intervention
F Hommen, S Bilican, D Vilchez
Journal of Neural Transmission 2021
Inhibition of TLR7 and TLR9 Reduces Human Cholangiocarcinoma Cell Proliferation and Tumor Development
FE Mohamed, R Jalan, S Minogue, F Andreola, A Habtesion, A Hall, A Winstanley, SO Damink, M Malagó, N Davies, TV Luong, A Dhillon, R Mookerjee, D Dhar, RM Al-Jehani
Digestive Diseases and Sciences 2021
Autophagy and organelle homeostasis in cancer
DR Miller, A Thorburn
Developmental Cell 2021
Autophagy in Viral Development and Progression of Cancer
A Suares, MV Medina, O Coso
Frontiers in Oncology 2021
Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance
R Shafabakhsh, F Arianfar, M Vosough, HR Mirzaei, M Mahjoubin-Tehran, H khanbabaei, H Kowsari, L Shojaie, ME Azar, MR Hamblin, H Mirzaei
Cancer Gene Therapy 2021
Autophagy Induction by Trichodermic Acid Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis in Colon Cancer Cells
J Qu, C Zeng, T Zou, X Chen, X Yang, Z Lin
International journal of molecular sciences 2021
Recent Advances in Understanding the Role of Autophagy in Paediatric Brain Tumours
F Gatto, G Milletti, A Carai, A Mastronuzzi, F Nazio
Diagnostics 2021
The Oxygen-Generating Calcium Peroxide-Modified Magnetic Nanoparticles Attenuate Hypoxia-Induced Chemoresistance in Triple-Negative Breast Cancer
FY Cheng, CH Chan, BJ Wang, YL Yeh, YJ Wang, HW Chiu
Cancers 2021
Molecular interactions of miR-338 during tumor progression and metastasis
M Moghbeli
Cellular & Molecular Biology Letters 2021
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells
A Besaratinia, AW Caliri, S Tommasi
DNA repair 2021
Autophagy-Related Three-Gene Prognostic Signature for Predicting Survival in Esophageal Squamous Cell Carcinoma
H Cui, Y Weng, N Ding, C Cheng, L Wang, Y Zhou, L Zhang, Y Cui, W Zhang
Frontiers in Oncology 2021
mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
A Cayo, R Segovia, W Venturini, R Moore-Carrasco, C Valenzuela, N Brown
International journal of molecular sciences 2021
ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1
Ž Frangež, D Gérard, Z He, M Gavriil, Y Fernández-Marrero, SM Jafari, RE Hunger, P Lucarelli, S Yousefi, T Sauter, L Sinkkonen, HU Simon
Frontiers in Oncology 2021
Establishment of an Autophagy-Related Clinical Prognosis Model for Predicting the Overall Survival of Osteosarcoma
J Li, X Tang, Y Du, J Dong, Z Zhao, H Hu, T Song, J Guo, Y Wang, T Xu, C Shao, Y Sheng, , SA Rotenberg
BioMed Research International 2021
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
YH Cui, S Yang, J Wei, CR Shea, W Zhong, F Wang, P Shah, MG Kibriya, X Cui, H Ahsan, C He, YY He
Nature Communications 2021
Lipid Droplets and Their Autophagic Turnover via the Raft-Like Vacuolar Microdomains
MA Rahman, R Kumar, E Sanchez, TY Nazarko
International journal of molecular sciences 2021
The Interplay Between Tumor Suppressor p53 and Hypoxia Signaling Pathways in Cancer
C Zhang, J Liu, J Wang, T Zhang, D Xu, W Hu, Z Feng
Frontiers in Cell and Developmental Biology 2021
CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity
B Liu, Y Lu, T Zhang, X Yu, Q Wang, Y Chi, S Jin, G Cheng
Cell Communication and Signaling 2021
Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease
Y Ohashi
Autophagy 2021
Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway
XP Tan, Y He, YN Huang, CC Zheng, JQ Li, QW Liu, ML He, B Li, WW Xu
2021
Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease
P Díaz, A Sandoval-Bórquez, R Bravo-Sagua, AF Quest, S Lavandero
Frontiers in Cell and Developmental Biology 2021
Mutant p53 as a Regulator and Target of Autophagy
Y Shi, E Norberg, H Vakifahmetoglu-Norberg
Frontiers in Oncology 2021
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR
M He, G Yan, Y Wang, R Gong, H Lei, S Yu, X He, G Li, W Du, T Ma, M Gao, M Yu, S Liu, Z Xu, E Idiiatullina, N Zagidullin, V Pavlov, B Cai, Y Yuan, L Yang
Journal of Cellular and Molecular Medicine 2021
Directed evolution of cyclic peptides for inhibition of autophagy
JP Gray, N Uddin, R Chaudhari, MN Sutton, H Yang, P Rask, H Locke, BJ Engel, N Batistatou, J Wang, BJ Grindel, P Bhattacharya, ST Gammon, S Zhang, D Piwnica-Worms, JA Kritzer, Z Lu, RC Bast, SW Millward
Chemical Science 2021
CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51
W Zheng, Q Chen, H Liu, S Hu, Y Zhou, Y Bai, J Zhang, Y Pan, C Shao
Cancers 2021
YAP promotes autophagy and progression of gliomas via upregulating HMGB1
M Zhao, Y Zhang, Y Jiang, K Wang, X Wang, D Zhou, Y Wang, R Yu, X Zhou
Journal of Experimental & Clinical Cancer Research 2021
Modulation of Autophagy in Cancer Cells by Dietary Polyphenols
C Musial, K Siedlecka-Kroplewska, Z Kmiec, M Gorska-Ponikowska
Antioxidants 2021
A Novel Autophagy-Related lncRNA Prognostic Signature Associated with Immune Microenvironment and Survival Outcomes of Gastric Cancer Patients
D Chen, M Wang, Y Xu, X Jiang, L Xiong, L Zhang, H Yu, Z Xiong
International journal of general medicine 2021
Emerging roles of ATG7 in human health and disease
JJ Collier, F Suomi, M Oláhová, TG McWilliams, RW Taylor
EMBO Molecular Medicine 2021
Cell Survival and Cell Death at the Intersection of Autophagy and Apoptosis: Implications for Current and Future Cancer Therapeutics
N Bata, ND Cosford
2021
Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications
D Chen, S Ping, Y Xu, M Wang, X Jiang, L Xiong, L Zhang, H Yu, Z Xiong
Frontiers in Cell and Developmental Biology 2021
New Look of EBV LMP1 Signaling Landscape
L Wang, S Ning
Cancers 2021
Atg5 Regulates Selective Autophagy of the Parental Macronucleus during Tetrahymena Sexual Reproduction
T Bo, Y Kang, Y Liu, J Xu, W Wang
Cells 2021
Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation
Y Luo, S Zheng, Q Wu, J Wu, R Zhou, C Wang, Z Wu, X Rong, N Huang, L Sun, J Bin, Y Liao, M Shi, W Liao
Autophagy 2021
Autophagy and tumorigenesis
M Rangel, J Kong, V Bhatt, K Khayati, J Guo
The FEBS journal 2021
Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression
C Cerda-Troncoso, M Varas-Godoy, P Burgos
Frontiers in Oncology 2021
A Blueprint for Cancer-Related Inflammation and Host Innate Immunity
L García-López, I Adrados, D Ferres-Marco, M Dominguez
Cells 2021
Beclin 1, LC3 and P62 Expression in Equine Sarcoids
M Martano, G Altamura, K Power, P Liguori, B Restucci, G Borzacchiello, P Maiolino
Animals 2021
A narrative review of multiple mechanisms of progranulin in cancer: a potential target for anti-cancer therapy
C Zhou, Y Huang, J Wu, Y Wei, X Chen, Z Lin, S Nie
Translational cancer research 2021
LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation
L Liang, L Huan, J Wang, Y Wu, S Huang, X He
Cell Discovery 2021
PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
P Fan, V Jordan
Molecular cancer research : MCR 2021
Therapeutic Targeting of Autophagy in Pancreatic Ductal Adenocarcinoma
AG Raufi, NR Liguori, L Carlsen, C Parker, LH Borrero, S Zhang, X Tian, A Louie, L Zhou, AA Seyhan, WS El-Deiry
Frontiers in pharmacology 2021
Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells
Chen Y, Wang R, Huang S, Henson ES, Bi J, Gibson SB
Cancers 2021
miR-143-3p inhibits endometriotic stromal cell proliferation and invasion by inactivating autophagy in endometriosis
Yang H, Hu T, Hu P, Qi C, Qian L
Molecular medicine reports 2021
Identification of novel autophagy-related lncRNAs associated with a poor prognosis of colon adenocarcinoma through bioinformatics analysis
Wu D, Yin Z, Ji Y, Li L, Li Y, Meng F, Ren X, Xu M
Scientific Reports 2021
PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway
Han Z, Liu D, Chen L, He Y, Tian X, Qi L, Chen L, Luo Y, Chen Z, Hu X, Li G, Zhan L, Wang Y, Li Q, Chen P, Liu Z, Guo H
Cell Death and Disease 2021
A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation
Sabarwal A, Wedel J, Liu K, Zurakowski D, Chakraborty S, Flynn E, Briscoe DM, Balan M, Pal S
Carcinogenesis 2021
Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway.
Wang C, Wang W, Han X, Du L, Li A, Huang G
Oncology Letters 2021
MYG1 promotes proliferation and inhibits autophagy in lung adenocarcinoma cells via the AMPK/mTOR complex 1 signaling pathway.
Han X, Li A, Wang W, Du L, Wang C, Huang G
Oncology Letters 2021
Macrophage autophagy protects against hepatocellular carcinogenesis in mice.
Deust A, Chobert MN, Demontant V, Gricourt G, Denaës T, Thiolat A, Ruiz I, Rodriguez C, Pawlotsky JM, Teixeira-Clerc F
Scientific Reports 2021
Dynamic supramolecular self-assembly of platinum(ii) complexes perturbs an autophagy-lysosomal system and triggers cancer cell death.
Tong KC, Wan PK, Lok CN, Che CM
Chemical Science 2021
Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches-a narrative review.
Zolondick AA, Gaudino G, Xue J, Pass HI, Carbone M, Yang H
2021
A gene toolbox for monitoring autophagy transcription
Bordi M, De Cegli R, Testa B, Nixon RA, Ballabio A, Cecconi F
Cell Death and Disease 2021
Autophagy-Related Gene Pairs Signature for the Prognosis of Hepatocellular Carcinoma
Luo Y, Liu F, Han S, Qi Y, Hu X, Zhou C, Liang H, Zhang Z
Frontiers in Molecular Biosciences 2021
Acute Valproate Exposure Induces Mitochondrial Biogenesis and Autophagy with FOXO3a Modulation in SH-SY5Y Cells
Jang EH, Lee JH, Kim SA
Cells 2021
Modulation of Cancer Cell Autophagic Responses by Graphene-Based Nanomaterials: Molecular Mechanisms and Therapeutic Implications.
Ristic B, Harhaji-Trajkovic L, Bosnjak M, Dakic I, Mijatovic S, Trajkovic V
Cancers 2021
Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells-Are There New Avenues for Treatment?
Apilan AG, Mothersill C
International journal of molecular sciences 2021
TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma.
Lu H, Zhu C, Ruan Y, Fan L, Wei K, Yang Z, Chen Q
Analytical cellular pathology (Amsterdam) 2021
Regulation of Butyrate-Induced Resistance through AMPK Signaling Pathway in Human Colon Cancer Cells.
Yoo HY, Park SY, Chang SY, Kim SH
Biomedicines 2021
Polysaccharides from sporoderm-removed spores of Ganoderma lucidum induce apoptosis in human gastric cancer cells via disruption of autophagic flux
Zhong J, Fang L, Chen R, Xu J, Guo D, Guo C, Guo C, Chen J, Chen C, Wang X
Oncology Letters 2021
Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide
Bischoff ME, Zang Y, Chu J, Price AD, Ehmer B, Talbot NJ, Newbold MJ, Paul A, Guan JL, Plas DR, Meller J, Czyzyk-Krzeska MF
The Journal of Cell Biology 2021
Epigenomic Analysis of RAD51 ChIP-seq Data Reveals cis-regulatory Elements Associated with Autophagy in Cancer Cell Lines
Kang K, Choi Y, Moon H, You C, Seo M, Kwon G, Yun J, Beck B, Kang K
Cancers 2021
Autophagy: The Potential Link between SARS-CoV-2 and Cancer
Habibzadeh P, Dastsooz H, Eshraghi M, Łos MJ, Klionsky DJ, Ghavami S
Cancers 2021
HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent Insights
Passaro E, Papulino C, Chianese U, Toraldo A, Congi R, Del Gaudio N, Nicoletti MM, Benedetti R, Altucci L
Cancers 2021
Saponins in Cancer Treatment: Current Progress and Future Prospects
Elekofehinti OO, Iwaloye O, Olawale F, Ariyo EO
Pathophysiology 2021
NICE-3-knockdown induces cell cycle arrest and autophagy in lung adenocarcinoma cells via the AKT/mTORC1 signaling pathway.
Du L, Wu Y, Han X, Wang C, Li A, Huang G
Experimental and therapeutic medicine 2021
Sestrin2 as a gatekeeper of cellular homeostasis: Physiological effects for the regulation of hypoxia-related diseases.
Pan C, Chen Z, Li C, Han T, Liu H, Wang X
Journal of Cellular and Molecular Medicine 2021
The Carcinogen Cadmium Activates Lysine 63 (K63)-Linked Ubiquitin-Dependent Signaling and Inhibits Selective Autophagy
Chargui A, Belaid A, Ndiaye PD, Imbert V, Samson M, Guigonis JM, Tauc M, Peyron JF, Poujeol P, Brest P, Hofman P, Mograbi B
Cancers 2021
原纤毛及其在肿瘤发生发展中的作用
MAO H, SUN Y
2021
CDCA4 suppresses epithelial–mesenchymal transtion (EMT) and metastasis in Non-small cell lung cancer through modulating autophagy
Xu C, Cao H, Sui Y, Zhang H, Shi C, Wu J, Ma R, Feng J
Cancer Cell International 2021
Autophagy and Exosomes Relationship in Cancer: Friends or Foes?
Colletti M, Ceglie D, Di Giannatale A, Nazio F
Frontiers in Cell and Developmental Biology 2021
Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy
Wang Z, Xie Q, Zhou H, Zhang M, Shen J, Ju D
Frontiers in pharmacology 2021
Insights of roles played by septins in pathogenic fungi
Li L, Zhu XM, Su ZZ, Del Poeta M, Liu XH, Lin FC
Virulence 2021
ATG4B Inhibitor UAMC-2526 Potentiates the Chemotherapeutic Effect of Gemcitabine in a Panc02 Mouse Model of Pancreatic Ductal Adenocarcinoma
Takhsha FS, Vangestel C, Tanc M, De Bruycker S, Berg M, Pintelon I, Stroobants S, De Meyer GR, Van Der Veken P, Martinet W
Frontiers in Oncology 2021
Identification and validation of an autophagy-related signature for predicting survival in lower-grade glioma.
Feng S, Liu H, Dong X, Du P, Guo H, Pang Q
Bioengineered 2021
Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling.
Nazio F, Po A, Abballe L, Ballabio C, Diomedi Camassei F, Bordi M, Camera A, Caruso S, Caruana I, Pezzullo M, Ferraina C, Milletti G, Gianesello M, Reddel S, De Luca CD, Ceglie D, Marinelli S, Campello S, Papaleo E, Miele E, Cacchione A, Carai A, Vinci M, Velardi E, De Angelis B, Tiberi L, Quintarelli C, Mastronuzzi A, Ferretti E, Locatelli F, Cecconi F
Acta Neuropathologica 2021
LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
Chen H, Wei L, Luo M, Wang X, Zhu C, Huang H, Liu X, Lu H, Zhong Y
Cell Biology and Toxicology 2021
Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production
Liang X, Wang P, Yang C, Huang F, Wu H, Shi H, Wu X
Frontiers in pharmacology 2021
Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression
Gong X, Jiang L, Li W, Liang Q, Li Z
Bioengineered 2021
Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo
Ji Y, Hu W, Jin Y, Yu H, Fang J
Bioengineered 2021
Assessment of the Nutraceutical Effects of Oleuropein and the Cytotoxic Effects of Adriamycin, When Administered Alone and in Combination, in MG-63 Human Osteosarcoma Cells.
Gioti K, Papachristodoulou A, Benaki D, Aligiannis N, Skaltsounis AL, Mikros E, Tenta R
Nutrients 2021
ATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary report.
Rapisarda V, Broggi G, Caltabiano R, Lombardo C, Castorina S, Trovato A, Ledda C, Filetti V, Loreto C
Histology and histopathology 2021
Post-transcriptional regulation of ATG1 is a critical node that modulates autophagy during distinct nutrient stresses
Lahiri V, Metur SP, Hu Z, Song X, Mari M, Hawkins WD, Bhattarai J, Delorme-Axford E, Reggiori F, Tang D, Dengjel J, Klionsky DJ
Autophagy 2021
LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy.
Huang X, Zhang W, Pu F, Zhang Z
Genes & Diseases 2021
Autophagic Inhibition via Lysosomal Integrity Dysfunction Leads to Antitumor Activity in Glioma Treatment
HY Hwang, YS Cho, JY Kim, KN Yun, JS Yoo, E Lee, I Kim, HJ Kwon
Cancers 2020
Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles
O Unal, Y Akkoc, M Kocak, E Nalbat, AI Dogan-Ekici, HY Acar, D Gozuacik
Journal of nanobiotechnology 2020
Multi-Habitat Radiomics Unravels Distinct Phenotypic Subtypes of Glioblastoma with Clinical and Genomic Significance
SW Choi, HH Cho, H Koo, KR Cho, KH Nenning, G Langs, J Furtner, B Baumann, A Woehrer, HJ Cho, JK Sa, DS Kong, HJ Seol, JI Lee, DH Nam, H Park
Cancers 2020
miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells
W Liu, D Jiang, F Gong, Y Huang, Y Luo, Y Rong, J Wang, X Ge, C Ji, J Fan, W Cai
Cell Death and Disease 2020
Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein
E Dai, L Han, J Liu, Y Xie, G Kroemer, DJ Klionsky, HJ Zeh, R Kang, J Wang, D Tang
Autophagy 2020
Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein
JS Lee, EH Jang, HA Woo, K Lee
Cells 2020
IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro
Y Ma, J Li, ZP, J Zhang
Cell Death and Disease 2020
Role and Mechanisms of Mitophagy in Liver Diseases
X Ma, T McKeen, J Zhang, WX Ding
Cells 2020
Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition
P Peng, X Zhang, T Qi, H Cheng, Q Kong, L Liu, X Cao, Z Ding
FEBS Open Bio 2020
Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function: PIK3C3/VPS34 in T cell metabolism and function
G Yang, W Song, JL Postoak, J Chen, J Martinez, J Zhang, L Wu, LV Kaer
Autophagy 2020
Life, death, and autophagy in cancer: NF-κB turns up everywhere
D Verzella, A Pescatore, D Capece, D Vecchiotti, MV Ursini, G Franzoso, E Alesse, F Zazzeroni
Cell Death and Disease 2020
Targeting the HGF/MET Axis in Cancer Therapy: Challenges in Resistance and Opportunities for Improvement
X Huang, E Li, H Shen, X Wang, T Tang, X Zhang, J Xu, Z Tang, C Guo, X Bai, T Liang
Frontiers in Cell and Developmental Biology 2020
Molecular Insights Into Therapeutic Potential of Autophagy Modulation by Natural Products for Cancer Stem Cells
A Rahman, SK Saha, S Rahman, J Uddin, S Uddin, MG Pang, H Rhim, SG Cho
Frontiers in Cell and Developmental Biology 2020
Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition
AM Blessing, JM SantiagoO'Farrill, W Mao, L Pang, J Ning, D Pak, LR Bollu, P Rask, LK Iles, H Yang, S Tran, E Elmir, G Bartholomeusz, R Langley, Z Lu, RC Bast
Cancer 2020
A Novel Role for NUAK1 in Promoting Ovarian Cancer Metastasis through Regulation of Fibronectin Production in Spheroids
JL Fritz, O Collins, P Saxena, A Buensuceso, YR Valdes, KE Francis, KR Brown, B Larsen, K Colwill, AC Gingras, R Rottapel, TG Shepherd
Cancers 2020
A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status
A Garufi, S Baldari, R Pettinari, MS Montani, V DOrazi, G Pistritto, A Crispini, E Giorno, G Toietta, F Marchetti, M Cirone, G DOrazi
Journal of Experimental & Clinical Cancer Research 2020
Co-targeting Mitochondrial Ca2+ Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity
C Dubois, A Kondratskyi, G Bidaux, L Noyer, E Vancauwenberghe, V Farfariello, RA Toillon, M Roudbaraki, D Tierny, JL Bonnal, N Prevarskaya, FV Abeele
iScience 2020
Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes
H Jung, SB Seo, T Liu
PloS one 2020
Crosstalks between inflammasome and autophagy in cancer
C Chung, W Seo, P Silwal, EK Jo
Journal of Hematology & Oncology 2020
Anti-tumor immunity influences cancer cell reliance upon ATG7
MD Arensman, XS Yang, W Zhong, S Bisulco, E Upeslacis, EC Rosfjord, S Deng, RT Abraham, CH Eng
OncoImmunology 2020
Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era
X Zhang, CP Deibert, WJ Kim, E Jaman, AV Rao, MT Lotze, NM Amankulor
Cancer Gene Therapy 2020
A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
J Cui, J Liu, L Fan, Y Zhu, B Zhou, Y Wang, W Hua, W Wei, G Sun
Translational oncology 2020
Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond
N Wesch, V Kirkin, VV Rogov
Cells 2020
Merkel Cell Polyomavirus and Merkel Cell Carcinoma
V Pietropaolo, C Prezioso, U Moens
Cancers 2020
DEPDC1 up‐regulates RAS expression to inhibit autophagy in lung adenocarcinoma cells
W Wang, A Li, X Han, Q Wang, J Guo, Y Wu, C Wang, G Huang
Journal of Cellular and Molecular Medicine 2020
Autophagy and liver cancer
X Chao, H Qian, S Wang, S Fulte, WX Ding
Clinical and Molecular Hepatology 2020
New Insights into Therapy-Induced Progression of Cancer
PV Shnaider, OM Ivanova, IK Malyants, KS Anufrieva, IA Semenov, MS Pavlyukov, MA Lagarkova, VM Govorun, VO Shender
International journal of molecular sciences 2020
The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway
J Liu, C Zhang, J Wang, W Hu, Z Feng
International journal of molecular sciences 2020
Menin-mediated Repression of Glycolysis in Combination with Autophagy Protects Colon Cancer Against Small-molecule EGFR Inhibitors
BW Katona, T Hojnacki, RA Glynn, KE Paulosky, KM Szigety, Y Cao, X Zhang, Z Feng, X He, J Ma, X Hua
Molecular cancer therapeutics 2020
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer
J Ma, J Qi, S Li, C Zhang, H Wang, L Shao, X Yuan, Q Sha
Technology in cancer research & treatment 2020
Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer
H Ren, NA Bakas, M Vamos, A Chaikuad, AS Limpert, CD Wimer, SN Brun, LJ Lambert, L Tautz, M Celeridad, DJ Sheffler, S Knapp, RJ Shaw, ND Cosford
Journal of Medicinal Chemistry 2020
At a glance: A history of autophagy and cancer
X Wen, DJ Klionsky
Seminars in Cancer Biology 2020
HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner
S Castro-Gonzalez, Y Shi, M Colomer-Lluch, Y Song, K Mowery, S Almodovar, A Bansal, F Kirchhoff, K Sparrer, C Liang, R Serra-Moreno
Autophagy 2020
Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine
MP George, MT Gladwin, BB Graham
American journal of respiratory cell and molecular biology 2020
Dietary Energy Modulation and Autophagy: Exploiting Metabolic Vulnerabilities to Starve Cancer
AJ Cozzo, MF Coleman, JB Pearce, AJ Pfeil, SK Etigunta, SD Hursting
Frontiers in Cell and Developmental Biology 2020
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes
Y Jiang, Y Gu, H Xu, X Tian, X Zhang, X Xu, W Yan, X Zhang
2020
Co‐targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics
AA AlBari
Journal of Cellular and Molecular Medicine 2020
Autophagy Takes Center Stage as a Possible Cancer Hallmark
JG Alvarez-Meythaler, Y Garcia-Mayea, C Mir, H Kondoh, ME LLeonart
Frontiers in Oncology 2020
Multifaceted activities of transcription factor EB in cancer onset and progression
E Astanina, F Bussolino, G Doronzo
Molecular Oncology 2020
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC
Y Cui, F Li, Q Xie, S Zhao, T Guo, P Guo, S Hu, J Hao, C Tian, W Yu, Z Li, L Fang, L Zhao, M Chen, T Wu, C Gu
Cell Death and Disease 2020
Autophagy and autophagy-related proteins in cancer
X Li, S He, B Ma
Molecular Cancer 2020
Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells
ST Pan, J Zhou, F Yang, SF Zhou, T Ren
BMC Cancer 2020
Increased Expression of Autophagy Protein LC3 in Two Patients With Progressing Chronic Lymphocytic Leukemia
DS Arroyo, CM Rodriguez, C Bussi, C Manzone-Rodriguez, D Sastre, V Heller, C Stanganelli, I Slavutsky, P Iribarren
Frontiers in Endocrinology 2020
The Role of Autophagy in Liver Cancer: Crosstalk in Signaling Pathways and Potential Therapeutic Targets
J Cui, HM Shen, LH Lim
Pharmaceuticals (Basel, Switzerland) 2020
The RBP1–CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma
L Gao, Q Wang, W Ren, J Zheng, S Li, Z Dou, X Kong, X Liang, K Zhi
Cell Death and Disease 2020
The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside
K Görgülü, KN Diakopoulos, E Kaya-Aksoy, KJ Ciecielski, J Ai, M Lesina, H Algül
Cells 2020

Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer


Y Liu, N Zhang, H Zhang, L Wang, Y Duan, X Wang, T Chen, Y Liang, Y Li, X Song, C Li, D Han, B Chen, W Zhao, Q Yang
Drug design, development and therapy 2020
High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways
SB Song, ES Hwang
Biomolecules 2020
Combination of an Autophagy Inducer and an Autophagy Inhibitor: A Smarter Strategy Emerging in Cancer Therapy
T Liu, J Zhang, K Li, L Deng, H Wang
Frontiers in pharmacology 2020
Biological functions and theranostic potential of HMGB family members in human cancers
L Niu, W Yang, L Duan, X Wang, Y Li, C Xu, C Liu, Y Zhang, W Zhou, J Liu, Q Zhao, Y Han, L Hong, D Fan
Therapeutic advances in medical oncology 2020
DAPK3 inhibits gastric cancer progression via activation of ULK1-dependent autophagy
GM Li, L Li, MQ Li, X Chen, Q Su, ZJ Deng, HB Liu, B Li, WH Zhang, YX Jia, WJ Wang, JY Ma, HL Zhang, D Xie, XF Zhu, YL He, XY Guan, J Bi
Cell Death and Differentiation 2020
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
M Dohmen, S Krieg, G Agalaridis, X Zhu, SN Shehata, E Pfeiffenberger, J Amelang, M Bütepage, E Buerova, CM Pfaff, D Chanda, S Geley, C Preisinger, K Sakamoto, B Lüscher, D Neumann, J Vervoorts
Nature Communications 2020
LOXL2 Upregulation in Gliomas Drives Tumorigenicity by Activating Autophagy to Promote TMZ Resistance and Trigger EMT
Q Zhang, L Yang, G Guan, P Cheng, W Cheng, A Wu
Frontiers in Oncology 2020
Autophagy as a modulator of cell death machinery
M Noguchi, N Hirata, T Tanaka, F Suizu, H Nakajima, JA Chiorini
Cell Death and Disease 2020
Autophagy Roles in Genome Maintenance
S Ambrosio, B Majello
Cancers 2020
Development of an autophagy-related gene prognostic signature in lung adenocarcinoma and lung squamous cell carcinoma
J Zhu, M Wang, D Hu
PeerJ 2020
Identification of small molecule drugs and development of a novel autophagy‐related prognostic signature for kidney renal clear cell carcinoma
Q Xing, C Ji, B Zhu, R Cong, Y Wang
Cancer Medicine 2020
Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer
EA Nollet, M Cardo-Vila, SS Ganguly, JD Tran, VV Schulz, A Cress, E Corey, CK Miranti
Oncogene 2020
Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy
H Jin, J Ma, J Xu, H Li, Y Chang, N Zang, Z Tian, X Wang, N Zhao, L Liu, C Chen, Q Xie, Y Lu, Z Fang, X Huang, C Huang, H Huang
Autophagy 2020
Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation
F Yang, S Sun, C Wang, M Haas, S Yeo, J Guan
British Journal of Cancer 2020
Saikosaponin D inhibits autophagosome‑lysosome fusion and induces autophagy‑independent apoptosis in MDA‑MB‑231 breast cancer cells
R Fu, L Zhang, Y Li, B Li, Y Ming, Z Li, H Xing, J Chen
Molecular medicine reports 2020
Targeting apoptosis in cancer therapy
BA Carneiro, WS El-Deiry
Nature Reviews Clinical Oncology 2020
The impacts of ubiquilin 1 (UBQLN1) knockdown on cells viability, proliferation, and apoptosis are mediated by p53 in A549 lung cancer cells
X Zhang, Y Su, H Lin, X Yao
Journal of Thoracic Disease 2020
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020
TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
Chen Y, Mo L, Wang X, Chen B, Hua Y, Gong L, Yang F, Li Y, Chen F, Zhu G, Ni W, Zhang C, Cheng Y, Luo Y, Shi J, Qiu M, Wu S, Tan Z, Wang K
Aging 2020
SH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells
Kim TW, Cheon C, Ko SG
Cell Death and Disease 2020
Inhibition of autophagy enhances apoptosis induced by bortezomib in AML cells
Jiang L, Zhao YM, Yang MZ
Oncology Letters 2020
Development of a Novel Autophagy-Related Prognostic Signature and Nomogram for Hepatocellular Carcinoma
Fang Q, Chen H
Frontiers in Oncology 2020
Modulating lysosomal pH: a molecular and nanoscale materials design perspective
Zeng J, Shirihai OS, Grinstaff MW
Journal of life sciences (Westlake Village, Calif.) 2020
Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment.
Wang Y, Sun L, Qiu W, Qi W, Qi Y, Liu Z, Liu S, Lv J
Aging 2020
Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes.
Hino H, Iriyama N, Kokuba H, Kazama H, Moriya S, Takano N, Hiramoto M, Aizawa S, Miyazawa K
Cancer Science 2020
Neferine treatment enhances the TRAIL‑induced apoptosis of human prostate cancer cells via autophagic flux and the JNK pathway.
Nazim UM, Yin H, Park SY
International journal of oncology 2020
Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway.
Lv M, Zhuang X, Zhang Q, Cheng Y, Wu D, Wang X, Qiao T
Cell Biology and Toxicology 2020
The Macro-Autophagy-Related Protein Beclin-1 Immunohistochemical Expression Correlates With Tumor Cell Type and Clinical Behavior of Uveal Melanoma.
Broggi G, Ieni A, Russo D, Varricchio S, Puzzo L, Russo A, Reibaldi M, Longo A, Tuccari G, Staibano S, Caltabiano R
Frontiers in Oncology 2020
The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment.
Wada Y, Tokuda K, Morine Y, Okikawa S, Yamashita S, Ikemoto T, Imura S, Saito Y, Yamada S, Shimada M
Oncotarget 2020
Understanding the mechanisms of silica nanoparticles for nanomedicine
Li Z, Mu Y, Peng C, Lavin MF, Shao H, Du Z
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2020
Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy.
Manirujjaman M, Ozaki I, Murata Y, Guo J, Xia J, Nishioka K, Perveen R, Takahashi H, Anzai K, Matsuhashi S
Cells 2020
Kindlin-2 suppresses cervical cancer cell migration through AKT/mTOR-mediated autophagy induction
Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, Yao D
Oncology reports 2020
Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation
Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS
Environmental Health Perspectives 2020
siMTA1-Loaded Exosomes Enhanced Chemotherapeutic Effect of Gemcitabine in Luminal-b Type Breast Cancer by Inhibition of EMT/HIF-α and Autophagy Pathways
Li P, Cao G, Huang Y, Wu W, Chen B, Wang Z, Xiong M
Frontiers in Oncology 2020
Germacrone protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy processes in PC12 cells.
Zhang J, Yuan L, Wang S, Liu J, Bi H, Chen G, Li J, Chen L
2020
A Robust Signature Based on Autophagy-Associated LncRNAs for Predicting Prognosis in Lung Adenocarcinoma.
Zhou M, Shao W, Dai H, Zhu X
BioMed Research International 2020
Autophagy Suppresses Toll-Like Receptor 3-Mediated Inflammatory Reaction in Human Epidermal Keratinocytes.
Li XM, Jung KE, Yim SH, Hong DK, Kim CD, Hong JY, Lee HJ, Lee SY, Kim JE, Park CW
BioMed Research International 2020
Identification and validation of an individualized autophagy-clinical prognostic index in gastric cancer patients.
Qiu J, Sun M, Wang Y, Chen B
Cancer Cell International 2020
Rapamycin Reduces Cervical Cancer Cells Viability in Hypoxic Condition: Investigation of the Role of Autophagy and Apoptosis
Rezazadeh D, Norooznezhad AH, Mansouri K, Jahani M, Mostafaie A, Mohammadi MH, Modarressi MH
OncoTargets and therapy 2020
SPAG5 is associated with unfavorable prognosis in patients with lung adenocarcinoma and promotes proliferation, motility and autophagy in A549 cells
Huang R, Li A
Experimental and therapeutic medicine 2020
Identification of Survival-Associated Alternative Splicing Signatures in Lung Squamous Cell Carcinoma
Liu Y, Jia W, Li J, Zhu H, Yu J
Frontiers in Oncology 2020
Synergy of Tumor Microenvironment Remodeling and Autophagy Inhibition to Sensitize Radiation for Bladder Cancer Treatment.
Lin T, Zhang Q, Yuan A, Wang B, Zhang F, Ding Y, Cao W, Chen W, Guo H
Theranostics 2020
Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis.
Liu L, Yan Z, Wang Y, Meng J, Chen G
Oncology Letters 2020
Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation.
Wang J, Bian S, Wang S, Yang S, Zhang W, Zhao D, Liu M, Bai X
Chinese medicine 2020
Knockdown of Parkinson's disease-related gene ATP13A2 reduces tumorigenesis via blocking autophagic flux in colon cancer.
Chen Q, Zhong L, Zhou C, Feng Y, Liu QX, Zhou D, Lu X, Du GS, Jian D, Luo H, Wang D, Zheng H, Qiu Y
Cell & Bioscience 2020
Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy
Wang Z, Wang X, Zhang N, Zhang H, Dai Z, Zhang M, Feng S, Cheng Q
Frontiers in Cell and Developmental Biology 2020
Arsenic trioxide as a novel anti-glioma drug: a review
Fang Y, Zhang Z
Cellular & Molecular Biology Letters 2020
Exosomes derived from bone marrow mesenchymal stem cells promote osteosarcoma development by activating oncogenic autophagy.
Huang Y, Liu W, He B, Wang L, Zhang F, Shu H, Sun L
Journal of Bone Oncology 2020
Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells.
Zhong W, Tang X, Liu Y, Zhou C, Liu P, Li E, Zhong P, Lv H, Zou Q, Wang M
Molecules (Basel, Switzerland) 2020
Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis.
Laski J, Singha B, Wang X, Valdés YR, Collins O, Shepherd TG
Journal of Ovarian Research 2020
Identification and validation of prognostic signature for breast cancer based on genes potentially involved in autophagy.
Zhong S, Chen H, Yang S, Feng J, Zhou S
PeerJ 2020
An Autophagy-Related Gene Signature Associated With Clinical Prognosis and Immune Microenvironment in Gliomas.
Xu Y, Li R, Li X, Dong N, Wu D, Hou L, Yin K, Zhao C
Frontiers in Oncology 2020
Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6
Fujiwara N, Shibutani S, Sakai Y, Watanabe T, Kitabayashi I, Oshima H, Oshima M, Hoshida H, Akada R, Usui T, Ohama T, Sato K
Cancer Science 2020
Increased TRIM5 is associated with a poor prognosis and immune infiltration in glioma patients
CHEN Y, LI Q, ZHANG J, GU R, LI K, ZHAO G, YUAN H, FENG T, OU D, LIN P
2020
OP16 induces deadly autophagy and apoptosis of cells by inhibiting Akt in esophageal squamous cell carcinoma.
Hou G, Jia A, Yang L, Zhao Y, Hu Y, Zhao W, Zhao W, Liu HM, Lu Z
Molecular and Cellular Biochemistry 2020
Development of pharmaceutically scalable inhaled anti-cancer nanotherapy – Repurposing amodiaquine for non-small cell lung cancer (NSCLC)
Parvathaneni V, Kulkarni NS, Chauhan G, Shukla SK, Elbatanony R, Patel B, Kunda NK, Muth A, Gupta V
Materials science & engineering. C, Materials for biological applications 2020
Hallmarks of Aging: An Autophagic Perspective
MC Barbosa, RA Grosso, CM Fader
Frontiers in Endocrinology 2019
Is Autophagy Involved in the Diverse Effects of Antidepressants?
T Rein
Cells 2019
Tumour necrosis factor-α-induced protein 8-like 2 is a novel regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells
DD Wu, SY Liu, YR Gao, D Lu, Y Hong, YG Chen, PZ Dong, DY Wang, T Li, HM Li, ZG Ren, JC Guo, F He, XQ Ren, SY Sun, SF Duan, XY Ji
Journal of Cellular and Molecular Medicine 2019
The lysosome as a cellular centre for signalling, metabolism and quality control
RE Lawrence, R Zoncu
Nature Cell Biology 2019
Autophagy-Modulating Long Non-coding RNAs (LncRNAs) and Their Molecular Events in Cancer
ZI Khan, SY Tam, HK Law
Frontiers in Genetics 2019
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer
M Saldana, K VanderVorst, AL Berg, H Lee, KL Carraway
Endocrine Related Cancer 2019
Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets
B Ballester, J Milara, J Cortijo
International journal of molecular sciences 2019
Autophagy: Dual Response in the Development of Hepatocellular Carcinoma
H Yazdani, H Huang, A Tsung
Cells 2019
Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
PL Wei, CY Huang, YJ Chang, YH Hsieh
PloS one 2019
AutophagySMDB: a curated database of small molecules that modulate protein targets regulating autophagy
R Nanduri, R Kalra, E Bhagyaraj, AP Chacko, N Ahuja, D Tiwari, S Kumar, M Jain, R Parkesh, P Gupta
Autophagy 2019
Reprogramming of Energy Metabolism in Response to Radiotherapy in Head and Neck Squamous Cell Carcinoma
A Cruz-Gregorio, I Martínez-Ramírez, J Pedraza-Chaverri, M Lizano
Cancers 2019
Selective Autophagy Regulates Cell Cycle in Cancer Therapy
K Zheng, Z He, K Kitazato, Y Wang
Theranostics 2019
A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death
HH Park, SW Choi, GJ Lee, YD Kim, HJ Noh, SJ Oh, I Yoo, YJ Ha, GB Koo, SS Hong, SW Kwon, YS Kim
Journal of Ginseng Research 2019
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
T Tian, X Li, J Zhang
International journal of molecular sciences 2019
Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
J Beauvarlet, P Bensadoun, E Darbo, G Labrunie, B Rousseau, E Richard, I Draskovic, A Londono-Vallejo, JW Dupuy, RN Das, A Guédin, G Robert, F Orange, S Croce, V Valesco, P Soubeyran, KM Ryan, JL Mergny, M Djavaheri-Mergny
Nucleic Acids Research 2019
Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer
S Chipurupalli, E Kannan, V Tergaonkar, R DAndrea, N Robinson
International journal of molecular sciences 2019
Targeting autophagy potentiates antitumor activity of Met-TKIs against Met-amplified gastric cancer
X Lin, Z Peng, X Wang, J Zou, D Chen, Z Chen, Z Li, B Dong, J Gao, L Shen
Cell Death and Disease 2019
Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma
H Zhuang, F Wu, W Wei, Y Dang, B Yang, X Ma, F Han, Y Li
Cell Death and Disease 2019
Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases
HC Chi, CY Tsai, MM Tsai, CT Yeh, KH Lin
Journal of Biomedical Science 2019
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer
RM Perera, CD Malta, A Ballabio
Annual Review of Cancer Biology 2019
The emerging role of STING-dependent signaling on cell death
F Sun, Z Liu, Z Yang, S Liu, W Guan
Immunologic Research 2019
Role of autophagy during the replication and pathogenesis of common mosquito-borne flavi- and alphaviruses
L Echavarria-Consuegra, JM Smit, F Reggiori
Open Biology 2019
Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1
J Ketteler, A Panic, H Reis, A Wittka, P Maier, C Herskind, E Yagüe, V Jendrossek, D Klein
Journal of Clinical Medicine 2019
Dual Role of the Alternative Reading Frame ARF Protein in Cancer
R Fontana, M Ranieri, GL Mantia, M Vivo
Biomolecules 2019
Elevated pulmonary tuberculosis biomarker miR-423-5p plays critical role in the occurrence of active TB by inhibiting autophagosome-lysosome fusion
H Tu, S Yang, T Jiang, L Wei, L Shi, C Liu, C Wang, H Huang, Y Hu, Z Chen, J Chen, Z Li, J Li
Emerging Microbes & Infections 2019
Ubiquitination of MAP1LC3B by pVHL is associated with autophagy and cell death in renal cell carcinoma
HM Kang, KH Noh, TK Chang, D Park, HS Cho, JH Lim, CR Jung
Cell Death and Disease 2019
Primary Cilium in Cancer Hallmarks
L Fabbri, F Bost, N Mazure
International journal of molecular sciences 2019
Differential effects of ginkgol C17:1 on cisplatin‑induced cytotoxicity: Protecting human normal L02 hepatocytes versus sensitizing human hepatoma HepG2 cells
Y Li, X Zhang, X Yang, J Liu, L Li, W Ma, M Chen
Oncology Letters 2019
Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
V Lahiri, WD Hawkins, DJ Klionsky
Cell Metabolism 2019
DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1
MN Sutton, GY Huang, X Liang, R Sharma, AS Reger, W Mao, L Pang, PJ Rask, K Lee, JP Gray, AM Hurwitz, T Palzkill, SW Millward, C Kim, Z Lu, RC Bast
Cancers 2019
Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression
MN Sutton, GY Huang, J Zhou, W Mao, R Langley, Z Lu, RC Bast
Cancers 2019
The Role of HOX Transcription Factors in Cancer Predisposition and Progression
B Li, Q Huang, GH Wei
Cancers 2019
Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
G DOrazi, M Cirone
Cancers 2019
Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway
A Kulshrestha, GK Katara, SA Ibrahim, V Riehl, M Sahoo, J Dolan, KW Meinke, MR Pins, KD Beaman
Journal of Oncology 2019
Molecular pathogenic pathways in extranodal NK/T cell lymphoma
S de Mel, SS Hue, AD Jeyasekharan, WJ Chng, SB Ng
Journal of Hematology & Oncology 2019
Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR
B Zhang, Y Song, S Sun, R Han, C Hua, S van der Veen, H Cheng, L Banks
Journal of virology 2019
MIR93 ( microRNA -93 ) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy
T Huang, X Wan, AA Alvarez, CD James, X Song, Y Yang, N Sastry, I Nakano, EP Sulman, B Hu, SY Cheng
Autophagy 2019
Recombinant adenoviruses expressing apoptin suppress the growth of MCF‑7 breast cancer cells and affect cell autophagy
S Chen, YQ Li, XZ Yin, SZ Li, YL Zhu, YY Fan, WJ Li, YL Cui, J Zhao, X Li, QG Zhang, NY Jin
Oncology reports 2019
Inhibition LC3B can increase chemosensitivity of ovarian cancer cells
J Tang, J Zhu, Y Ye, Y Liu, Y He, L Zhang, D Tang, C Qiao, X Feng, J Li, Y Kan, X Li, X Jin, D Kong
Cancer Cell International 2019
Transcriptional Regulation of Autophagy: Mechanisms and Diseases
CD Malta, L Cinque, C Settembre
Frontiers in Cell and Developmental Biology 2019
Activation of Aurora A kinase increases YAP stability via blockage of autophagy
P Wang, Y Gong, T Guo, M Li, L Fang, S Yin, M Kamran, Y Liu, J Xu, L Xu, F Peng, X Xue, M Yang, MC Hung, EW Lam, C Gu, C Wang, Q Zhan, Q Liu
Cell Death and Disease 2019
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells
R He, M Wang, C Zhao, M Shen, Y Yu, L He, Y Zhao, H Chen, X Shi, M Zhou, S Pan, Y Liu, X Guo, X Li, R Qin
Journal of Experimental & Clinical Cancer Research 2019
The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy
J Wang, S Xie, J Yang, H Xiong, Y Jia, Y Zhou, Y Chen, X Ying, C Chen, C Ye, L Wang, J Zhou
Journal of Hematology & Oncology 2019
Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux
Z Wen, W Zeng, Y Chen, H Li, J Wang, Q Cheng, J Yu, H Zhou, Z Liu, J Xiao, X Chen
Journal of Experimental & Clinical Cancer Research 2019
PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation
JM Rodríguez-Vargas, FJ Oliver-Pozo, F Dantzer
Oxidative medicine and cellular longevity 2019
Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells
MJ Kang, SY Kim, EB Kwon, YH Jo, MK Lee, HS Lee, DO Moon, MO Kim, I Ulasov
PloS one 2019
Bibliometric analysis of research on the trends in autophagy
T Hong, X Feng, W Tong, W Xu
PeerJ 2019
Omega 3-DHA and Delta-Tocotrienol Modulate Lipid Droplet Biogenesis and Lipophagy in Breast Cancer Cells: the Impact in Cancer Aggressiveness
Pizato, Kiffer, Luzete, Assumpção, Correa, Melo, SantAna, Ito, Magalhães
Nutrients 2019
Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
JY Ko, EJ Lee, JH Park
Biomolecules and Therapeutics 2019
Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation
YC Li, AJ Cheng, LY Lee, YC Huang, JT Chang
Journal of Cancer 2019
Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation
J Yan, X Dou, J Zhou, Y Xiong, L Mo, L Li, Y Lei
Journal of Experimental & Clinical Cancer Research 2019
Autophagy: New Insights into Mechanisms of Action and Resistance of Treatment in Acute Promyelocytic leukemia
MA Moosavi, M Djavaheri-Mergny
International journal of molecular sciences 2019
Store-Operated Ca2+ Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications
YF Chen, PC Lin, YM Yeh, LH Chen, MR Shen
Cancers 2019
Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma
X Gao, P Jiang, Q Zhang, Q Liu, S Jiang, L Liu, M Guo, Q Cheng, J Zheng, H Yao
Journal of Experimental & Clinical Cancer Research 2019
Effect of early-stage autophagy inhibition in BRAFV600E autophagy-dependent brain tumor cells
S Zahedi, BE Fitzwalter, A Morin, S Grob, M Desmarais, A Nellan, AL Green, R Vibhakar, TC Hankinson, NK Foreman, JM Levy
Cell Death and Disease 2019
β2‑adrenergic receptor signaling promotes neuroblastoma cell proliferation by activating autophagy
J Deng, P Jiang, T Yang, M Huang, J Xie, C Luo, W Qi, T Zhou, Z Yang, Y Zou, G Gao, X Yang
Oncology reports 2019
Ginsenoside Compound K Induces Ros-Mediated Apoptosis and Autophagic Inhibition in Human Neuroblastoma Cells In Vitro and In Vivo
JM Oh, E Kim, S Chun
International journal of molecular sciences 2019
The Autophagy Lysosomal Pathway and Neurodegeneration
S Finkbeiner
Cold Spring Harbor perspectives in biology 2019
The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy
F Liang, C Ren, J Wang, S Wang, L Yang, X Han, Y Chen, G Tong, G Yang
Oncogenesis 2019
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
M Liu, T Sun, N Li, J Peng, D Fu, W Li, L Li, WQ Gao
Nature Communications 2019
Loss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy
MG Lee, MA Choi, S Chae, MA Kang, H Jo, J Baek, KR In, H Park, H Heo, D Jang, S Brito, ST Kim, DO Kim, JS Lee, JR Kim, BH Bin
Scientific Reports 2019
LncRNAs as Regulators of Autophagy and Drug Resistance in Colorectal Cancer
M Bermúdez, M Aguilar-Medina, E Lizárraga-Verdugo, M Avendaño-Félix, E Silva-Benítez, C López-Camarillo, R Ramos-Payán
Frontiers in Oncology 2019
Improved Survival in Hepatocellular Carcinoma Patients with Cardiac Arrhythmia by Amiodarone Treatment through Autophagy
Huang, Hsu, Huang, Yen, Lin, Peng, Yen
International journal of molecular sciences 2019
PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism
Y Tan, Y Jin, X Wu, Z Ren
BMC Molecular Biology 2019
Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization
M Pérez-Hernández, A Arias, D Martínez-García, R Pérez-Tomás, R Quesada, V Soto-Cerrato
Cancers 2019
Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells
BG Harder, S Peng, CP Sereduk, AM Sodoma, GJ Kitange, JC Loftus, JN Sarkaria, NL Tran
Molecular Medicine 2019
The positive correlation of TIPRL with LC3 and CD133 contributes to cancer aggressiveness: potential biomarkers for early liver cancer
SY Jun, SJ Jeon, JY Yoon, JJ Lee, HR Yoon, MH Choi, D Halder, K Lee, NS Kim
Scientific Reports 2019
Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells
A Sipos, KJ Kim, C Sioutas, ED Crandall
International journal of molecular sciences 2019
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy
Q Cao, X You, L Xu, L Wang, Y Chen
Autophagy 2019
Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes
S Kumar, H Xie, H Shi, J Gao, CC Juhlin, V Björnhagen, A Höög, L Lee, C Larsson, WO Lui
International Journal of Cancer 2019
Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy
O di Martino, JS Welch
Cancers 2019
Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
RA Rather, M Bhagat
Cancer Medicine 2019
Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition
RA Denu, G Kaur, MM Sass, A Lakkaraju, ME Burkard
Molecular cancer research : MCR 2019
Chaperone-Mediated Autophagy in the Liver: Good or Bad?
S Dash, Y Aydin, K Moroz
Cells 2019
Molecular Determinants of Cancer Therapy Resistance to HDAC Inhibitor-Induced Autophagy
M Mrakovcic, LF Fröhlich
Cancers 2019
The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers
S Ning, L Wang
Current cancer drug targets 2019
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts
E Sugawara, M Kato, Y Kudo, W Lee, R Hisada, Y Fujieda, K Oku, T Bohgaki, O Amengual, S Yasuda, T Onodera, S Hatakeyama, T Atsumi
Autophagy 2019
Salidroside enhances the anti-cancerous effect of imatinib on human acute monocytic leukemia via the induction of autophagy-related apoptosis through AMPK activation
Ge C, Zhang J, Feng F
RSC Advances 2019
Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability.
Kilchrist KV, Dimobi SC, Jackson MA, Evans BC, Werfel TA, Dailing EA, Bedingfield SK, Kelly IB, Duvall CL
ACS Nano 2019
Targeting autophagy-related protein kinases for potential therapeutic purpose.
Xiang H, Zhang J, Lin C, Zhang L, Liu B, Ouyang L
Acta pharmaceutica Sinica. B 2019
COX7A1 suppresses the viability of human non‐small cell lung cancer cells via regulating autophagy
Zhao L, Chen X, Feng Y, Wang G, Nawaz I, Hu L, Liu P
Cancer Medicine 2019
TRPM2 mediates distruption of autophagy machinery and correlates with the grade level in prostate cancer.
Tektemur A, Ozaydin S, Etem Onalan E, Kaya N, Kuloglu T, Ozercan İH, Tekin S, Elyas HM
Journal of Cancer Research and Clinical Oncology 2019
Knockdown of mitofilin inhibits autophagy and facilitates starvation-induced apoptosis in HeLa cells.
Shen M, Wang L, Kuang L, Liu D
Iranian Journal of Basic Medical Sciences 2019
Roles for Autophagy in Esophageal Carcinogenesis: Implications for Improving Patient Outcomes
Saxena R, Klochkova A, Murray MG, Kabir MF, Samad S, Beccari T, Gang J, Patel K, Hamilton KE, Whelan KA
Cancers 2019
Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy.
Taylor MA, Khathayer F, Ray SK
Neurochemical Research 2019
W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors.
Liang D, Wang HY, Fan S, Wang J, Shen Y, Gao CY, Wu ML, Lu SM, Zhang SQ, Han W
Investigational new drugs 2019
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells
Themis Alissafi, Aikaterini Hatzioannou, Konstantinos Mintzas, Roza Maria Barouni, Aggelos Banos, Sundary Sormendi, Alexandros Polyzos, Maria Xilouri, Ben Wielockx, Helen Gogas, Panayotis Verginis
Journal of Clinical Investigation 2018
Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers
H Yu, S Yin, S Zhou, Y Shao, J Sun, X Pang, L Han, Y Zhang, X Gao, C Jin, Y Qiu, T Wang
Cell Death and Disease 2018
Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition
AN Young, D Herrera, AC Huntsman, MA Korkmaz, DD Lantvit, S Mazumder, S Kolli, CC Coss, S King, H Wang, SM Swanson, AD Kinghorn, X Zhang, MA Phelps, LN Aldrich, JR Fuchs, JE Burdette
Molecular cancer therapeutics 2018
Autophagy in Cancer: Regulation by Small Molecules
AS Limpert, LJ Lambert, NA Bakas, N Bata, SN Brun, RJ Shaw, ND Cosford
Trends in Pharmacological Sciences 2018
Autophagy and intermittent fasting: the connection for cancer therapy?
F Antunes, AG Erustes, AJ Costa, AC Nascimento, C Bincoletto, RP Ureshino, GJ Pereira, SS Smaili
Clinics 2018
Autophagy and Hallmarks of Cancer
T Huang, X Song, Y Yang, X Wan, AA Alvarez, N Sastry, H Feng, B Hu, SY Cheng
Critical Reviews in Oncogenesis 2018
2-Aminoethoxydiphenylborane sensitizes anti-tumor effect of bortezomib via suppression of calcium-mediated autophagy
YQ Qu, F Gordillo-Martinez, BY Law, Y Han, A Wu, W Zeng, WK Lam, C Ho, SW Mok, HQ He, VK Wong, R Wang
Cell Death and Disease 2018
AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms
C Nwadike, LE Williamson, LE Gallagher, JL Guan, EY Chan
Molecular and cellular biology 2018
Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation
A Walker, A Singh, E Tully, J Woo, A Le, T Nguyen, S Biswal, D Sharma, E Gabrielson
Free radical biology & medicine 2018
Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ–AMPK–mTOR pathway in ADPKD cells
W Shi, D Xu, J Gu, C Xue, B Yang, L Fu, S Song, D Liu, W Zhou, J Lv, K Sun, M Chen, C Mei
Molecular and Cellular Biochemistry 2018
Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells
YP Liu, L Li, L Xu, EN Dai, WD Chen
Oncology Letters 2018
Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer
J Lee, S Yi, M Won, YS Song, HS Yi, YJ Park, KC Park, JT Kim, JY Chang, MJ Lee, HJ Sul, JE Choi, KS Kim, J Kero, J Kim, M Shong
Oncogene 2018
Pharmacological targets of breast cancer stem cells: a review
SK Pindiprolu, PT Krishnamurthy, PK Chintamaneni
Naunyn-Schmiedeberg's Archives of Pharmacology 2018
18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma
J Chen, Z Zhang, J Song, Q Liu, C Wang, Z Huang, L Chu, H Liang, B Zhang, X Chen
Scientific Reports 2018
A novel Atg5 -shRNA mouse model enables temporal control of Autophagy in vivo
LD Cassidy, AR Young, PA Pérez-Mancera, B Nimmervoll, A Jaulim, HC Chen, DJ McIntyre, R Brais, T Ricketts, S Pacey, MD Roche, RJ Gilbertson, DC Rubinsztein, M Narita
Autophagy 2018
Avenues to molecular imaging of dying cells: Focus on cancer
AA Rybczynska, HH Boersma, S de Jong, JA Gietema, W Noordzij, RA Dierckx, PH Elsinga, A van Waarde
Medicinal Research Reviews 2018
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence
L Vera-Ramirez, SK Vodnala, R Nini, KW Hunter, JE Green
Nature Communications 2018
Regulation of Tumor Progression by Programmed Necrosis
SY Lee, MK Ju, HM Jeon, EK Jeong, YJ Lee, CH Kim, HG Park, SI Han, HS Kang
Oxidative medicine and cellular longevity 2018
p53-Autophagy-Metastasis Link
T Denisenko, A Pivnyuk, B Zhivotovsky
Cancers 2018
Emerging role of lipid metabolism alterations in Cancer stem cells
M Yi, J Li, S Chen, J Cai, Y Ban, Q Peng, Y Zhou, Z Zeng, S Peng, X Li, W Xiong, G Li, B Xiang
Journal of Experimental & Clinical Cancer Research 2018
β-Cell Autophagy in Diabetes Pathogenesis
MR Marasco, AK Linnemann
Endocrinology 2018
The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance
DE Biancur, AC Kimmelman
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2018
MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
CL Hsu, EX Lee, KL Gordon, EA Paz, WC Shen, K Ohnishi, J Meisenhelder, T Hunter, AR Spada
Nature Communications 2018
Human Papilloma Virus and Autophagy
D Mattoscio, A Medda, S Chiocca
International journal of molecular sciences 2018
Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival
S Bhattacharjee, P Bose, K Patel, SG Roy, C Gain, H Gowda, ES Robertson, A Saha
Cell Death and Disease 2018
STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy
JF Chen, P Wu, R Xia, J Yang, XY Huo, DY Gu, CJ Tang, W De, F Yang
Molecular Cancer 2018
When nature’s robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies
JA Reisz, AS Barrett, T Nemkov, KC Hansen, A DAlessandro
Expert Review of Proteomics 2018
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis
HH Lin, Y Chung, CT Cheng, C Ouyang, Y Fu, CY Kuo, KK Chi, M Sadeghi, P Chu, HJ Kung, CF Li, KH Limesand, DK Ann
Autophagy 2018
Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells
Q Fan, L Yang, X Zhang, Y Ma, Y Li, L Dong, Z Zong, X Hua, D Su, H Li, J Liu
Journal of Experimental & Clinical Cancer Research 2018
What We Learned From Big Data for Autophagy Research
AC Jacomin, L Gul, P Sudhakar, T Korcsmaros, IP Nezis
Frontiers in Cell and Developmental Biology 2018
Selective autophagy restricts IL-9 secretion from T H 9 cells: relevance in cancer growth
I Benoit-Lizon, E Jacquin, L Apetoh
Cell cycle (Georgetown, Tex.) 2018
Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?
AC Jacomin, E Taillebourg, MO Fauvarque
Cells 2018
Iron and Cancer
SV Torti, DH Manz, BT Paul, N Blanchette-Farra, FM Torti
Annual Review of Nutrition 2018
6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound
H Sha, Z Wang, S Dong, T Hu, S Liu, J Zhang, Y Wu, R Ma, J Wu, D Chen, J Feng
Bioscience Reports 2018
LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells
C Chen, K Wang, Q Wang, X Wang
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2018
Functional characterization of lysosomal interaction of Akt with VRK2
N Hirata, F Suizu, M Matsuda-Lennikov, T Tanaka, T Edamura, S Ishigaki, T Donia, P Lithanatudom, C Obuse, T Iwanaga, M Noguchi
Oncogene 2018
Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model
H Draz, AA Goldberg, ES Guns, L Fazli, S Safe, JT Sanderson
Investigational New Drugs 2018
Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1
F Lucantoni, H Dussmann, JH Prehn
Frontiers in Cell and Developmental Biology 2018
Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma
Y Egawa, C Saigo, Y Kito, T Moriki, T Takeuchi, A Ahmad
PloS one 2018
Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy
T Shen, LD Cai, YH Liu, S Li, WJ Gan, XM Li, JR Wang, PD Guo, Q Zhou, XX Lu, LN Sun, JM Li
Journal of Hematology & Oncology 2018
LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis
F Huang, W Chen, J Peng, Y Li, Y Zhuang, Z Zhu, C Shao, W Yang, H Yao, S Zhang
Molecular Cancer 2018
Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E
Y Wang, X Zhang, J Fan, W Chen, J Luan, Y Nan, S Wang, Q Chen, Y Zhang, Y Wu, D Ju
Frontiers in immunology 2018
Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells
L Zhang, Y Lei, Y Zhang, Y Li, Y Bu, F Song, C Zhang
Genes & Diseases 2018
In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis: Autophagy and endometriosis
S Matsuzaki, JL Pouly, M Canis
British Journal of Pharmacology 2018
Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism
A Arruabarrena-Aristorena, A Zabala-Letona, A Carracedo
Science Advances 2018
Autophagy as a cytoprotective mechanism in esophageal squamous cell carcinoma
TM Hall, MP Tétreault, KE Hamilton, KA Whelan
Current Opinion in Pharmacology 2018
Autophagy modulation: a prudent approach in cancer treatment?
E Bishop, TD Bradshaw
Cancer Chemotherapy and Pharmacology 2018
Heme oxygenase inhibition in cancers: possible tools and targets
P Podkalicka, O Mucha, A Józkowicz, J Dulak, A Łoboda
WSPOLCZESNA ONKOL 2018
Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy
SO Bustos, GJ da Silva Pereira, R de Freitas Saito, CD Gil, DB Zanatta, SS Smaili, R Chammas
Oncotarget 2018
Mechanisms, pathophysiological roles and methods for analyzing mitophagy – recent insights
JA Williams, WX Ding
Biological Chemistry 2018
Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin
S Bigelsen
Cancer management and research 2018
Hydroxychloroquine and risk of development of cancers: a nationwide population-based cohort study
IC Mao, CY Lin, CL Wu, CT Kor, CC Chang
Therapeutics and Clinical Risk Management 2018
Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma
MI Molejon, M Swayden, D Fanale, J Bintz, O Gayet, P Soubeyran, J Iovanna
Oncotarget 2018
An autophagy-related gene expression signature for survival prediction in multiple cohorts of hepatocellular carcinoma patients
P Lin, RQ He, YW Dang, DY Wen, J Ma, Y He, G Chen, H Yang
Oncotarget 2018
Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism
S Goruppi, SH Jo, C Laszlo, A Clocchiatti, V Neel, GP Dotto
Cell Reports 2018
TFDP3 regulates the apoptosis and autophagy in breast cancer cell line MDA-MB-231
L Ding, M Chu, Y Jiao, Q Hao, P Xiao, H Li, Q Guo, Y Wang, A Ahmad
PloS one 2018
Histone methyl-transferases and demethylases in the autophagy regulatory network: the emerging role of KDM1A/LSD1 demethylase
S Ambrosio, A Ballabio, B Majello
Autophagy 2018
Marsdenia tenacissima extract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells
YN Jiao, LN Wu, D Xue, , ZH Tian, ST Jiang, SY Han, PP Li
Cancer Cell International 2018
Autophagy Promotes Tumor-like Stem Cell Niche Occupancy
S Zhao, TM Fortier, EH Baehrecke
Current biology : CB 2018
Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135
MQ Zhang, JR Li, ZP, JP Zhang
Frontiers in immunology 2018
Autophagy Inhibition Promotes Bevacizumab-induced Apoptosis and Proliferation Inhibition in Colorectal Cancer Cells
Z Zhao, G Xia, N Li, R Su, X Chen, L Zhong
Journal of Cancer 2018
Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo
CY Sun, CY Li, XF Li, Y Zhu, ZQ Su, XQ Wang, QL He, GJ Zheng, B Feng
Journal of Cancer 2018
Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy
M Liu, L Jiang, X Fu, W Wang, J Ma, T Tian, K Nan, X Liang
Cancer Science 2018
Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis
YJ Hu, JY Zhang, Q Luo, JR Xu, Y Yan, LM Mu, J Bai, WL Lu
Nanomaterials 2018
Chromosomal instability causes sensitivity to protein folding stress and ATP depletion
M Khan, Z Shaukat, R Saint, SL Gregory
Biology Open 2018
Sicilian Litchi Fruit Extracts Induce Autophagy versus Apoptosis Switch in Human Colon Cancer Cells
S Emanuele, A Notaro, AP Piccionello, A Maggio, M Lauricella, A DAnneo, C Cernigliaro, G Calvaruso, M Giuliano
Nutrients 2018
Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis
Q Yin, W Feng, X Shen, S Ju
Bioscience Reports 2018
AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields)
A Shteingauz, Y Porat, T Voloshin, RS Schneiderman, M Munster, E Zeevi, N Kaynan, K Gotlib, M Giladi, ED Kirson, U Weinberg, A Kinzel, Y Palti
Cell Death and Disease 2018
The Roles of Autophagy in Cancer
C Yun, S Lee
International journal of molecular sciences 2018
Modulators of Redox Metabolism in Head and Neck Cancer
X Chen, J Mims, X Huang, N Singh, E Motea, SM Planchon, M Beg, AW Tsang, M Porosnicu, ML Kemp, DA Boothman, CM Furdui
Antioxidants & Redox Signaling 2018
Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway
S Niture, MA Gyamfi, H Kedir, E Arthur, H Ressom, G Deep, D Kumar
Cell Communication and Signaling 2018
The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
Z Dong, H Cui
Cells 2018
Lysosome: The metabolic signaling hub
DW Lamming, L BarPeled
Traffic (Copenhagen, Denmark) 2018
The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers: A systematic review and meta-analysis
R Xu, Z Ji, C Xu, J Zhu
Medicine 2018
The NF-κB Factor Relish Regulates Atg1 Expression and Controls Autophagy
A Nandy, L Lin, PD Velentzas, LP Wu, EH Baehrecke, N Silverman
Cell Reports 2018
HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle
X Yang, P Xue, X Liu, X Xu, Z Chen
Cell Communication and Signaling 2018
ERK-mediated autophagy promotes inactivated Sendai virus (HVJ-E)-induced apoptosis in HeLa cells in an Atg3-dependent manner
T Wang, N Yu, M Qian, J Feng, S Cao, J Yin, Q Zhang
Cancer Cell International 2018
Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways
S Chirumbolo, G Bjørklund, R Lysiuk, A Vella, L Lenchyk, T Upyr
International journal of molecular sciences 2018
Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma
M Wei, J Peng, P Wu, P Chen, H Yang, Y Cui, L Yang
Cancer management and research 2018
Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
E Abad, Y García-Mayea, C Mir, D Sebastian, A Zorzano, D Potesil, Z Zdrahal, A Lyakhovich, ME Lleonart
Molecular & cellular proteomics : MCP 2018
The progression of HMGB1-induced autophagy in cancer biology
T Xu, L Jiang, Z Wang
OncoTargets and therapy 2018
Changes in expression of the autophagy-related genes MAP1LC3B and ATG7 in skeletal muscle of fattening Japanese Black cattle: a pilot study
T Nakanishi, T Tokunaga, T Ishida, I Kobayashi, Y Katahama, A Yano, L Erickson, S Kawahara
Asian-Australasian Journal of Animal Sciences 2018
The multifaceted role of autophagy in cancer and the microenvironment: FOLKERTS et al
H Folkerts, S Hilgendorf, E Vellenga, E Bremer, VR Wiersma
Medicinal Research Reviews 2018
p53-Mediated Molecular Control of Autophagy in Tumor Cells
Mrakovcic M, Fröhlich LF
Biomolecules 2018
Long non-coding RNA HOTTIP affects renal cell carcinoma progression by regulating autophagy via the PI3K/Akt/Atg13 signaling pathway.
Su Y, Lu J, Chen X, Liang C, Luo P, Qin C, Zhang J
Journal of Cancer Research and Clinical Oncology 2018
全反式维甲酸诱导肝癌细胞Hepa1-6成熟和分化过程中的自噬
2018
SOX3 can promote the malignant behavior of glioblastoma cells.
Marjanovic Vicentic J, Drakulic D, Garcia I, Vukovic V, Aldaz P, Puskas N, Nikolic I, Tasic G, Raicevic S, Garros-Regulez L, Sampron N, Atkinson MJ, Anastasov N, Matheu A, Stevanovic M
Cellular oncology (Dordrecht) 2018
Synectin Promotes Fibrogenesis by Regulating PDGFR Isoforms through Distinct Mechanisms
Mary Drinane, Usman Yaqoob, Haibin Yu, Fanghong Luo, Thomas Greuter, Juan P. Arab, Enis Kostallari, Vikas Verma, Jessica L. Maiers, Thiago Milech de Assuncao, Michael Simons, Debabrata Mukhopadhyay, Tatiana Kisseleva, David Brenner, Raul Urrutia, Gwen Lomberk, Yandong Gao, Giovanni Ligresti, Daniel J. Tschumperlin, Alexander Revzin, Sheng Cao, Vijay H. Shah
JCI Insight 2017
Ferroquine, the next generation antimalarial drug, has antitumor activity
A Kondratskyi, K Kondratska, FV Abeele, D Gordienko, C Dubois, RA Toillon, C Slomianny, S Lemière, P Delcourt, E Dewailly, R Skryma, C Biot, N Prevarskaya
Scientific Reports 2017
Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target
J New, L Arnold, M Ananth, S Alvi, M Thornton, L Werner, O Tawfik, H Dai, Y Shnayder, K Kakarala, TT Tsue, DA Girod, WX Ding, S Anant, SM Thomas
Cancer research 2017
Resistance to Metronomic Chemotherapy and Ways to Overcome it
MR Martinez, K Parra, R Saluja, G Francia, U Emmenegger
Cancer Letters 2017
Autophagy in the liver: functions in health and disease
T Ueno, M Komatsu
Nature Reviews Gastroenterology & Hepatology 2017
Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells
LE Tavera-Mendoza, T Westerling, E Libby, A Marusyk, L Cato, R Cassani, LA Cameron, SB Ficarro, JA Marto, J Klawitter, M Brown
Proceedings of the National Academy of Sciences 2017
Targeting Autophagy for Oncolytic Immunotherapy
L Hu, K Jiang, C Ding, S Meng
Biomedicines 2017
Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example
HA Badr, DM AlSadek, ME El-Houseini, CT Saeui, MP Mathew, KJ Yarema, H Ahmed
Biomaterials 2017
Gastrointestinal stromal tumors (GIST): Facing cell death between autophagy and apoptosis
G Ravegnini, G Sammarini, M Nannini, MA Pantaleo, G Biasco, P Hrelia, S Angelini
Autophagy 2017
Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors
S Ohnami, K Ohshima, T Nagashima, K Urakami, Y Shimoda, J Saito, A Naruoka, K Hatakeyama, T Mochizuki, M Serizawa, S Ohnami, M Kusuhara, K Yamaguchi
Molecular and Cellular Biochemistry 2017
Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer
G Liu, F Pei, F Yang, L Li, A Amin, S Liu, J Buchan, W Cho
International journal of molecular sciences 2017
Microenvironmental autophagy promotes tumour growth
NS Katheder, R Khezri, F OFarrell, SW Schultz, A Jain, MM Rahman, KO Schink, TA Theodossiou, T Johansen, G Juhász, D Bilder, A Brech, H Stenmark, TE Rusten
Nature 2017
The Role of Autophagy in Cancer
N Santana-Codina, JD Mancias, AC Kimmelman
Annual Review of Cancer Biology 2017
Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation
LR Gomes, CF Menck, AM Cuervo
Autophagy 2017
The Cytoskeleton–Autophagy Connection
DJ Kast, R Dominguez
Current Biology 2017
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
CP Webster, EF Smith, PJ Shaw, KJ de Vos
Frontiers in molecular neuroscience 2017
Autophagy and Tumor Metabolism
AC Kimmelman, E White
Cell Metabolism 2017
The Close Interconnection between Mitochondrial Dynamics and Mitophagy in Cancer
M Bordi, F Nazio, S Campello
Frontiers in Oncology 2017
Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer
GQ Chen, RH Gong, DJ Yang, G Zhang, AP Lu, SC Yan, SH Lin, ZX Bian
Cell Death and Disease 2017
Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death
E Turriani, DF Lázaro, S Ryazanov, A Leonov, A Giese, M Schön, MP Schön, C Griesinger, TF Outeiro, DJ Arndt-Jovin, D Becker
Proceedings of the National Academy of Sciences 2017
The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival
C Paiardi, Z Mirzoyan, S Zola, F Parisi, A Vingiani, M Pasini, P Bellosta
Genes & development 2017
Hypoxia Driven Glycation: Mechanisms and Therapeutic Opportunities
MI Khan, S Rath, VM Adhami, H Mukhtar
Seminars in Cancer Biology 2017
Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms
VK Wong, W Zeng, J Chen, XJ Yao, EL Leung, QQ Wang, P Chiu, BC Ko, BY Law
Frontiers in pharmacology 2017
Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy
YY Li, L Feun, A Thongkum, CH Tu, SM Chen, M Wangpaichitr, C Wu, M Kuo, N Savaraj
International journal of molecular sciences 2017
Molecularly targeted therapies for p53-mutant cancers
D Zhao, WM Tahaney, A Mazumdar, MI Savage, PH Brown
Cellular and Molecular Life Sciences 2017
Glucose restriction combined with autophagy inhibition and chemotherapy in HCT 116 spheroids decreases cell clonogenicity and viability regulated by tumor suppressor genes
MM Schroll, GJ LaBonia, KR Ludwig, AB Hummon
Journal of Proteome Research 2017
Structure of the WD40-domain of human ATG16L1: Structure of the WD40-Domain of Human ATG16L1
M Bajagic, A Archna, P Büsing, A Scrima
Protein Science 2017
Lysosomotropism depends on glucose: a chloroquine resistance mechanism
LE Gallagher, OA Radhi, MO Abdullah, AG McCluskey, M Boyd, EY Chan
Cell Death and Disease 2017
Autophagy and Inflammatory Response in the Tumor Microenvironment
D Ngabire, GD Kim
International journal of molecular sciences 2017
Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer
S Byun, E Lee, KW Lee
International journal of molecular sciences 2017
Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells
TR Vargas, Z Cai, Y Shen, M Dosset, I Benoit-Lizon, T Martin, A Roussey, RA Flavell, F Ghiringhelli, L Apetoh
Nature Communications 2017
Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells
HB Wu, S Yang, HY Weng, Q Chen, XL Zhao, WJ Fu, Q Niu, YF Ping, JM Wang, X Zhang, XH Yao, XW Bian
Autophagy 2017
Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway
S Ambrosio, CD Saccà, S Amente, S Paladino, L Lania, B Majello
Oncogene 2017
Identification of 7-(4′-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells
TY Wu, TY Cho, CK Lu, JP Liou, MC Chen
Scientific Reports 2017
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
L Tirinato, F Pagliari, T Limongi, M Marini, A Falqui, J Seco, P Candeloro, C Liberale, ED Fabrizio
Stem Cells International 2017
Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway
S Havaki, V Vlachou, C Zampetidis, P Selemenakis, A Kotsinas, E Mavrogonatou, S Rizou, E Kyrodimos, K Evangelou, D Kletsas, A Giatromanolaki, V Gorgoulis
International journal of molecular sciences 2017
Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway
Y Xu, Y Wang, A Yao, Z Xu, H Dou, S Shen, Y Hou, T Wang
Scientific Reports 2017
High mobility group A1 protein modulates autophagy in cancer cells
A Conte, S Paladino, G Bianco, D Fasano, R Gerlini, M Tornincasa, M Renna, A Fusco, D Tramontano, GM Pierantoni
Cell Death and Differentiation 2017
Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells
K Liu, J Lee, JY Kim, L Wang, Y Tian, ST Chan, C Cho, K Machida, D Chen, JH Ou
Molecular Cell 2017
N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux
R Ranieri, E Ciaglia, G Amodio, P Picardi, MC Proto, P Gazzerro, C Laezza, P Remondelli, M Bifulco, S Pisanti
Cell Death and Differentiation 2017
Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential Mechanisms and Implications for Anti-Cancer Therapy
MA el Maaty, S Wölfl
International journal of molecular sciences 2017
The role of autophagy in hepatocellular carcinoma: friend or foe
L Liu, JZ Liao, XX He, PY Li
Oncotarget 2017
TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma
TW Lin, MT Chen, LT Lin, PI Huang, WL Lo, YP Yang, KH Lu, YW Chen, SH Chiou, CW Wu
Oncotarget 2017
Autophagy is required for crizotinib-induced apoptosis in MET-amplified gastric cancer cells
RD Schroeder, W Choi, DS Hong, DJ McConkey
Oncotarget 2017
MicroRNA‑320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor‑1α
Y Liang, X Chen, Z Liang
Experimental and therapeutic medicine 2017
Induction of mitophagy-mediated antitumor activity with folate-appended methyl-β-cyclodextrin
K Kameyama, K Motoyama, N Tanaka, Y Yamashita, T Higashi, H Arima
International Journal of Nanomedicine 2017
miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathway
C Sun, FJ Wang, HG Zhang, XZ Xu, RC Jia, L Yao, PF Qiao
World journal of gastroenterology : WJG 2017
Anticancer Effects of the Marine Sponge Lipastrotethya sp. Extract on Wild-Type and p53 Knockout HCT116 Cells
K Choi, HK Lim, SR Oh, WH Chung, J Jung
Evidence-Based Complementary and Alternative Medicine 2017
Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia
Q Heydt, C Larrue, E Saland, S Bertoli, JE Sarry, A Besson, S Manenti, C Joffre, VM Mas
Oncogene 2017
Deconstructing networks of p53-mediated tumor suppression in vivo
AM Kaiser, LD Attardi
Cell Death and Differentiation 2017
Autophagy Roles in the Modulation of DNA Repair Pathways
L Gomes, C Menck, G Leandro
International journal of molecular sciences 2017
MicroRNAs Associated with Von Hippel–Lindau Pathway in Renal Cell Carcinoma: A Comprehensive Review
LM Schanza, M Seles, M Stotz, J Fosselteder, G Hutterer, M Pichler, V Stiegelbauer
International journal of molecular sciences 2017
Herpesvirus and Autophagy: “All Right, Everybody Be Cool, This Is a Robbery!”
M Lussignol, A Esclatine
Viruses 2017
Editorial: Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
JD Lane, P Agostinis
Frontiers in Oncology 2017
MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
T Huang, CK Kim, AA Alvarez, RP Pangeni, X Wan, X Song, T Shi, Y Yang, N Sastry, CM Horbinski, S Lu, R Stupp, JA Kessler, R Nishikawa, I Nakano, EP Sulman, X Lu, CD James, XM Yin, B Hu, SY Cheng
Cancer Cell 2017
Implication of Different HIV-1 Genes in the Modulation of Autophagy
Z Liu, Y Xiao, C Torresilla, É Rassart, B Barbeau
Viruses 2017
ΔN-Bcl-xL, a therapeutic target for neuroprotection
HA Park, EA Jonas
NEURAL REGEN RES 2017
Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib
J Yuan, N Zhang, L Yin, H Zhu, L Zhang, L Zhou, M Yang
Scientific Reports 2017
In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors
SD Wood, W Grant, I Adrados, JY Choi, JM Alburger, DR Duckett, WR Roush
ACS Medicinal Chemistry Letters 2017
Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor–positive breast cancer
W Yang, SR Hosford, NA Traphagen, K Shee, E Demidenko, S Liu, TW Miller
The FASEB Journal 2017
Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin
NV Rajeshkumar, S Yabuuchi, SG Pai, ED Oliveira, JJ Kamphorst, JD Rabinowitz, H Tejero, F Al-Shahrour, M Hidalgo, A Maitra, CV Dang
Clinical cancer research 2017
TRIM29 as a prognostic predictor for multiple human malignant neoplasms: a systematic review and meta-analysis
C Liang, H Dong, C Miao, J Zhu, J Wang, P Li, J Li, Z Wang
Oncotarget 2017
Cancer and Aging - the Inflammatory Connection
A Zinger, WC Cho, A Ben-Yehuda
Aging and disease 2017
The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
JR Aunan, WC Cho, K Søreide
Aging and disease 2017
Prognostic significance of autophagy-related proteins expression in resected human gastric adenocarcinoma
B Qu, L Yao, H Ma, H Chen, Z Zhang, J Xie
Journal of Huazhong University of Science and Technology [Medical Sciences] 2017
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling
L Wang, W Guo, J Ma, W Dai, L Liu, S Guo, J Chen, H Wang, Y Yang, X Yi, G Wang, T Gao, G Zhu, C Li
Autophagy 2017
Chloroquine exerts antitumor effects on NB4 acute promyelocytic leukemia cells and functions synergistically with arsenic trioxide
S Liu, X Cai, L Xia, C Jiang, P Chen, X Wang, B Zhang, H Zhao
Oncology Letters 2017
Differences in the starvation-induced autophagy response in MDA-MB-231 and MCF-7 breast cancer cells
W Zhu, H Qu, K Xu, B Jia, H Li, Y Du, G Liu, HJ Wei, HY Zhao
Animal Cells and Systems 2017
Standard Immunohistochemical Assays to Assess Autophagy in Mammalian Tissue.
Martinet W, Roth L, De Meyer GRY
Cells 2017
Beclin1基因在SW620细胞自噬和凋亡中作用
2017
Intact Anti-Tumor Adaptive Immunity Following Autophagy Inhibition and Anti-Malarial Treatment
Hanna Starobinets, Jordan Ye, Miranda Broz, Kevin Barry, Juliet Goldsmith, Timothy Marsh, Fanya Rostker, Matthew Krummel, Jayanta Debnath
Journal of Clinical Investigation 2016
Dysregulation of Autophagy Contributes to Anal Carcinogenesis
EH Carchman, KA Matkowskyj, L Meske, PF Lambert, G Velasco
PloS one 2016
Fundamentals of cancer metabolism
RJ DeBerardinis, NS Chandel
Science Advances 2016
Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study
D Gaglio, S Valtorta, M Ripamonti, M Bonanomi, C Damiani, S Todde, AS Negri, F Sanvito, F Mastroianni, AD Campli, G Turacchio, GD Grigoli, S Belloli, A Luini, MC Gilardi, AM Colangelo, L Alberghina, RM Moresco
Oncotarget 2016
Autophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response
S Dash, S Chava, P Chandra, L Balart, T Wu, Y Aydin
Hepatic medicine : evidence and research 2016
Could Intermittent Energy Restriction and Intermittent Fasting Reduce Rates of Cancer in Obese, Overweight, and Normal-Weight Subjects? A Summary of Evidence
MN Harvie, T Howell
Advances in nutrition (Bethesda, Md.) 2016
Metabolic stress is a barrier to Epstein–Barr virus-mediated B-cell immortalization
K McFadden, AY Hafez, R Kishton, JE Messinger, PA Nikitin, JC Rathmell, MA Luftig
Proceedings of the National Academy of Sciences 2016
Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a-induced Autophagy in Pancreatic Intraepithelial Neoplasms
J Gong, G Belinsky, U Sagheer, X Zhang, PJ Grippo, C Chung
The Journal of biological chemistry 2016
Mechanisms of Selective Autophagy in Normal Physiology and Cancer
JD Mancias, AC Kimmelman
Journal of Molecular Biology 2016
Function of Autophagy in Nonalcoholic Fatty Liver Disease
MJ Czaja
Digestive Diseases and Sciences 2016
Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas
JR Delaney, DG Stupack, JS Castresana
PloS one 2016
Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer
E Yeh, J Zambrano
Breast cancer : basic and clinical research 2016
Genetics and biology of pancreatic ductal adenocarcinoma
H Ying, P Dey, W Yao, AC Kimmelman, GF Draetta, A Maitra, RA DePinho
Genes & development 2016
The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters
X Li, X Yu, D Dai, X Song, W Xu
Oncotarget 2016
Attacking the supply wagons to starve cancer cells to death
EM Selwan, BT Finicle, SM Kim, AL Edinger
FEBS Letters 2016
p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer
K Taniguchi, S Yamachika, F He, M Karin
FEBS Letters 2016
Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
Z Zhong, E Sanchez-Lopez, M Karin
Cell 2016
Mitochondria and Cancer
WX Zong, JD Rabinowitz, E White
Molecular Cell 2016
Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma
Y Furukawa, J Kikuchi
International Journal of Hematology 2016
Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer
Y Lei, Y Xie, YS Tan, ME Prince, JS Moyer, J Nör, GT Wolf
Oral Oncology 2016
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
F Pietrocola, J Pol, E Vacchelli, S Rao, DP Enot, EE Baracco, S Levesque, F Castoldi, N Jacquelot, T Yamazaki, L Senovilla, G Marino, F Aranda, S Durand, V Sica, A Chery, S Lachkar, V Sigl, N Bloy, A Buque, S Falzoni, B Ryffel, L Apetoh, F Di Virgilio, F Madeo, MC Maiuri, L Zitvogel, B Levine, JM Penninger, G Kroemer
Cancer Cell 2016
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk
C Zeng, K Matsuda, WH Jia, J Chang, SS Kweon, YB Xiang, A Shin, SH Jee, DH Kim, B Zhang, Q Cai, X Guo, J Long, N Wang, R Courtney, ZZ Pan, C Wu, A Takahashi, MH Shin, K Matsuo, F Matsuda, YT Gao, JH Oh, S Kim, KJ Jung, YO Ahn, Z Ren, HL Li, J Wu, J Shi, W Wen, G Yang, B Li, BT Ji, H Brenner, RE Schoen, S Küry, SB Gruber, FR Schumacher, SL Stenzel, G Casey, JL Hopper, MA Jenkins, HR Kim, JY Jeong, JW Park, K Tajima, SH Cho, M Kubo, XO Shu, D Lin, YX Zeng, W Zheng
Gastroenterology 2016
G protein γ subunit 7 induces autophagy and inhibits cell division
J Liu, X Ji, Z Li, X Yang, W Wang, X Zhang
Oncotarget 2016
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
T Saito, Y Ichimura, K Taguchi, T Suzuki, T Mizushima, K Takagi, Y Hirose, M Nagahashi, T Iso, T Fukutomi, M Ohishi, K Endo, T Uemura, Y Nishito, S Okuda, M Obata, T Kouno, R Imamura, Y Tada, R Obata, D Yasuda, K Takahashi, T Fujimura, J Pi, MS Lee, T Ueno, T Ohe, T Mashino, T Wakai, H Kojima, T Okabe, T Nagano, H Motohashi, S Waguri, T Soga, M Yamamoto, K Tanaka, M Komatsu
Nature Communications 2016
Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors
LM Lashinger, CH OFlanagan, SM Dunlap, AJ Rasmussen, S Sweeney, JY Guo, A Lodi, S Tiziani, E White, SD Hursting
Cancer & Metabolism 2016
Autophagy in Plasma Cell Ontogeny and Malignancy
E Milan, M Fabbri, S Cenci
Journal of Clinical Immunology 2016
Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome
C Follo, D Barbone, WG Richards, R Bueno, VC Broaddus
Autophagy 2016
Myosins, Actin and Autophagy: Myosins, Actin and Autophagy
AJ Kruppa, J Kendrick-Jones, F Buss
Traffic (Copenhagen, Denmark) 2016
Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
AM Ali, A Raza
Molecular & Cellular Oncology 2016
Polymeric chloroquine as an inhibitor of cancer cell migration and experimental lung metastasis
F Yu, J Li, Y Xie, RL Sleightholm, D Oupický
Journal of Controlled Release 2016
Connexins: substrates and regulators of autophagy
J Iyyathurai, JP Decuypere, L Leybaert, C Dhondt, G Bultynck
BMC cell biology 2016
Rapamycin-induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition: Autophagy radiosensitizes lung cancer
Y Li, F Liu, Y Wang, D Li, F Guo, L Xu, Z Zeng, X Zhong, K Qian
Thoracic Cancer 2016
Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner
S Tao, MR de la Vega, H Quijada, GT Wondrak, T Wang, JG Garcia, DD Zhang
Scientific Reports 2016
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
C Palumbo, AD Luca, N Rosato, M Forgione, D Rotili, AM Caccuri
Journal of Translational Medicine 2016
Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells
JY Guo, X Teng, SV Laddha, S Ma, SC van Nostrand, Y Yang, S Khor, CS Chan, JD Rabinowitz, E White
Genes & development 2016
Inhibition of Ral GTPases Using a Stapled Peptide Approach
JC Thomas, JM Cooper, NS Clayton, C Wang, MA White, C Abell, D Owen, HR Mott
The Journal of biological chemistry 2016
Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model
S Chen, C Wang, S Yeo, CC Liang, T Okamoto, S Sun, J Wen, JL Guan
Genes & development 2016
Atg7 cooperates with Pten loss to drive prostate cancer tumor growth
U Santanam, W Banach-Petrosky, C Abate-Shen, MM Shen, E White, RS DiPaola
Genes & development 2016
The cellular autophagy/apoptosis checkpoint during inflammation
JS Messer
Cellular and Molecular Life Sciences 2016
Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model
P Zhu, CJ Sieben, X Xu, PC Harris, X Lin
Human Molecular Genetics 2016
KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression
R Santarelli, M Granato, G Pentassuglia, V Lacconi, MS Montani, R Gonnella, M Tafani, MR Torrisi, A Faggioni, M Cirone
Autophagy 2016
mTORC1 and mTORC2 in cancer and the tumor microenvironment
LC Kim, RS Cook, J Chen
Oncogene 2016
Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma
S Demirsoy, S Martin, H Maes, P Agostinis
Frontiers in Oncology 2016
Therapeutic Targeting of Autophagy
CG Towers, A Thorburn
EBioMedicine 2016
Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells
F Angeletti, G Fossati, A Pattarozzi, R Würth, A Solari, A Daga, I Masiello, F Barbieri, T Florio, S Comincini
Frontiers in molecular neuroscience 2016
Complete mutational spectrum of the autophagy interactome: a novel class of tumor suppressor genes in myeloid neoplasms
V Visconte, B Przychodzen, Y Han, ST Nawrocki, S Thota, KR Kelly, BJ Patel, C Hirsch, AS Advani, HE Carraway, MA Sekeres, JP Maciejewski, JS Carew
Leukemia 2016
Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet
E Viry, MZ Noman, T Arakelian, A Lequeux, S Chouaib, G Berchem, E Moussay, J Paggetti, B Janji
Frontiers in Oncology 2016
Bacterial xenophagy and its possible role in cancer: A potential antimicrobial strategy for cancer prevention and treatment
X Sui, X Liang, L Chen, C Guo, W Han, H Pan, X Li
Autophagy 2016
Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192
RY Shyu, CH Wang, CC Wu, ML Chen, MC Lee, LK Wang, SY Jiang, FM Tsai
Molecules and Cells 2016
Autophagy and p53
E White
Cold Spring Harbor Perspectives in Medicine 2016
SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival
KE Maxfield, J Macion, H Vankayalapati, AW Whitehurst
Molecular and cellular biology 2016
Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity
V Deretic
Journal of leukocyte biology 2016
MARCH5 RNA promotes autophagy, migration, and invasion of ovarian cancer cells
J Hu, Y Meng, Z Zhang, Q Yan, X Jiang, Z Lv, L Hu
Autophagy 2016
Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells
P Castagnola, G Bellese, F Birocchi, MC Gagliani, C Tacchetti, K Cortese
Oncotarget 2016
Autophagy regulates the survival of cells with chromosomal instability
D Liu, Z Shaukat, T Xu, D Denton, R Saint, S Gregory
Oncotarget 2016
Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer
AM Schläfli, O Adams, JA Galván, M Gugger, S Savic, L Bubendorf, RA Schmid, KF Becker, MP Tschan, R Langer, S Berezowska
Oncotarget 2016
[Advances in the Research of Autophagy in EGFR-TKI Treatment and Resistance in Lung Cancer]
Qicheng Zhang, Ke Xu
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2016
Deoxyrhapontigenin, a Natural Stilbene Derivative Isolated From Rheum undulatum L. Induces Endoplasmic Reticulum Stress–Mediated Apoptosis in Human Breast Cancer Cells
T Venkatesan, MJ Jeong, YW Choi, EJ Park, SK El-Desouky, YK Kim
Integrative Cancer Therapies 2016
The Lysosome as a Regulatory Hub
Perera RM, Zoncu R
Annual Review of Cell and Developmental Biology 2016
Nutrient Restriction of Glucose or Serum Results in Similar Proteomic Expression Changes in 3D Colon Cancer Cell Cultures
Schroll MM, Liu X, Herzog SK, Skube SB, Hummon AB
Nutrition research (New York, N.Y.) 2016
Autophagy: a druggable process that is deregulated in aging and multiple human diseases
Guido Kroemer
Journal of Clinical Investigation 2015
mTOR: a pharmacological target for autophagy regulation
Young Chul Kim, Kun-liang Guan
Journal of Clinical Investigation 2015
Nanoparticles modulate autophagic effect in a dispersity-dependent manner
D Huang, H Zhou, J Gao
Scientific Reports 2015
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential
S Chauhan, Z Ahmed, SB Bradfute, J Arko-Mensah, MA Mandell, SW Choi, T Kimura, F Blanchet, A Waller, MH Mudd, S Jiang, L Sklar, GS Timmins, N Maphis, K Bhaskar, V Piguet, V Deretic
Nature Communications 2015
p62 links autophagy and Nrf2 signaling
T Jiang, B Harder, MR de la Vega, PK Wong, E Chapman, DD Zhang
Free radical biology & medicine 2015
Amino Acid Management in Cancer
ZY Tsun, R Possemato
Seminars in Cell & Developmental Biology 2015
Oncogenes strike a balance between cellular growth and homeostasis
B Qiu, MC Simon
Seminars in Cell & Developmental Biology 2015
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
DF Egan, MG Chun, M Vamos, H Zou, J Rong, CJ Miller, HJ Lou, D Raveendra-Panickar, CC Yang, DJ Sheffler, P Teriete, JM Asara, BE Turk, ND Cosford, RJ Shaw
Molecular Cell 2015
Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model
C Braicu, V Pileczki, L Pop, RC Petric, S Chira, E Pointiere, P Achimas-Cadariu, I Berindan-Neagoe, S Deb
PloS one 2015
Autophagy, Metabolism, and Cancer
E White, JM Mehnert, CS Chan
Clinical cancer research 2015
Autophagy inhibitors
B Pasquier
Cellular and Molecular Life Sciences 2015
MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation
Y Lu, L Xiao, Y Liu, H Wang, H Li, Q Zhou, J Pan, B Lei, A Huang, S Qi
Autophagy 2015
Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling
BC Koehler, A Jassowicz, AL Scherr, S Lorenz, P Radhakrishnan, N Kautz, C Elssner, J Weiss, D Jaeger, M Schneider, H Schulze-Bergkamen
BMC Cancer 2015
Cilia in autophagy and cancer
M Cao, Q Zhong
Cilia 2015
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer
Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG
Oncotarget 2015
Caveolin-1, a stress-related oncotarget, in drug resistance
Wang Z, Wang N, Liu P, Peng F, Tang H, Chen Q, Xu R, Dai Y, Lin Y, Xie X, Peng C, Situ H
Oncotarget 2015
Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth
Khurana A, Roy D, Kalogera E, Mondal S, Wen X, He X, Dowdy S, Shridhar V
Oncotarget 2015
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Altuntas S, Rossin F, Marsella C, D'Eletto M, Diaz-Hidalgo L, Farrace MG, Campanella M, Antonioli M, Fimia GM, Piacentini M
Oncotarget 2015
Zanthoxylum fruit extract from Japanese pepper promotes autophagic cell death in cancer cells
R Nozaki, T Kono, H Bochimoto, T Watanabe, K Oketani, Y Sakamaki, N Okubo, K Nakagawa, H Takeda
Oncotarget 2014
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

← Previous 1 2 … 10 11 12 … 30 31 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 4 news outlets
Posted by 3 X users
Referenced in 4 patents
On 1 Facebook pages
Referenced in 1 Wikipedia pages
Mentioned in 1 Google+ posts
On 1 videos
825 readers on Mendeley
1 readers on CiteULike
See more details