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Citations to this article

Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection
Guanfang Shi, … , Deborah J. Fowell, Craig N. Morrell
Guanfang Shi, … , Deborah J. Fowell, Craig N. Morrell
Published January 27, 2014
Citation Information: J Clin Invest. 2014;124(2):543-552. https://doi.org/10.1172/JCI71858.
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Research Article Article has an altmetric score of 18

Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection

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Abstract

Th cells are the major effector cells in transplant rejection and can be divided into Th1, Th2, Th17, and Treg subsets. Th differentiation is controlled by transcription factor expression, which is driven by positive and negative cytokine and chemokine stimuli at the time of T cell activation. Here we discovered that chemokine platelet factor 4 (PF4) is a negative regulator of Th17 differentiation. PF4-deficient and platelet-deficient mice had exaggerated immune responses to cardiac transplantation, including increased numbers of infiltrating Th17 cells and increased plasma IL-17. Although PF4 has been described as a platelet-specific molecule, we found that activated T cells also express PF4. Furthermore, bone marrow transplantation experiments revealed that T cell–derived PF4 contributes to a restriction in Th17 differentiation. Taken together, the results of this study demonstrate that PF4 is a key regulator of Th cell development that is necessary to limit Th17 differentiation. These data likely will impact our understanding of platelet-dependent regulation of T cell development, which is important in many diseases, in addition to transplantation.

Authors

Guanfang Shi, David J. Field, Kyung-ae Ko, Sara Ture, Kalyan Srivastava, Scott Levy, M. Anna Kowalska, Mortimer Poncz, Deborah J. Fowell, Craig N. Morrell

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Total
Citations: 1 3 4 8 7 5 3 7 3 3 3 6 53
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