In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure. Alterations in microRNA (miRNA) levels are associated with dysfunctional gene expression profiles associated with many cardiovascular disease conditions; however, miRNAs have emerged recently as paracrine signaling mediators. Thus, we investigated a potential paracrine miRNA crosstalk between cardiac fibroblasts and cardiomyocytes and found that cardiac fibroblasts secrete miRNA-enriched exosomes. Surprisingly, evaluation of the miRNA content of cardiac fibroblast–derived exosomes revealed a relatively high abundance of many miRNA passenger strands (“star” miRNAs), which normally undergo intracellular degradation. Using confocal imaging and coculture assays, we identified fibroblast exosomal–derived miR-21_3p (miR-21*) as a potent paracrine-acting RNA molecule that induces cardiomyocyte hypertrophy. Proteome profiling identified sorbin and SH3 domain-containing protein 2 (SORBS2) and PDZ and LIM domain 5 (PDLIM5) as miR-21* targets, and silencing SORBS2 or PDLIM5 in cardiomyocytes induced hypertrophy. Pharmacological inhibition of miR-21* in a mouse model of Ang II–induced cardiac hypertrophy attenuated pathology. These findings demonstrate that cardiac fibroblasts secrete star miRNA–enriched exosomes and identify fibroblast-derived miR-21* as a paracrine signaling mediator of cardiomyocyte hypertrophy that has potential as a therapeutic target.
Claudia Bang, Sandor Batkai, Seema Dangwal, Shashi Kumar Gupta, Ariana Foinquinos, Angelika Holzmann, Annette Just, Janet Remke, Karina Zimmer, Andre Zeug, Evgeni Ponimaskin, Andreas Schmiedl, Xiaoke Yin, Manuel Mayr, Rashi Halder, Andre Fischer, Stefan Engelhardt, Yuanyuan Wei, Andreas Schober, Jan Fiedler, Thomas Thum
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Berberine alleviates myocardial ischemia–reperfusion injury by inhibiting inflammatory response and oxidative stress: the key function of miR-26b-5p-mediated PTGS2/MAPK signal transduction
Jia X, Shao W, Tian S |
Pharmaceutical Biology | 2022 |
Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy
Silva J, da Costa Martins PA |
Cells | 2022 |
Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts
Askenase PW |
International journal of molecular sciences | 2022 |
MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology
Nothnick WB |
Cells | 2022 |
Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells
Ottaviani L, Juni RP, de Abreu RC, Sansonetti M, Sampaio-Pinto V, Halkein J, Hegenbarth JC, Ring N, Knoops K, Kocken JM, Jesus CD, Ernault AC, el Azzouzi H, Rühle F, Olieslagers S, Fernandes H, Ferreira L, Braga L, Stoll M, Nascimento DS, de Windt LJ, da Costa Martins PA |
Molecular Therapy | 2022 |
Mesenchymal Stem Cells Inhibits Migration and Vasculogenic Mimicry in Nasopharyngeal Carcinoma Via Exosomal MiR-125a
Wan F, Zhang H, Hu J, Chen L, Geng S, Kong L, Lu JJ |
Frontiers in Oncology | 2022 |
Cardiac fibroblasts secrete exosome microRNA to suppress cardiomyocyte pyroptosis in myocardial ischemia/reperfusion injury
Liu N, Xie L, Xiao P, Chen X, Kong W, Lou Q, Chen F, Lu X |
Molecular and Cellular Biochemistry | 2022 |
Cellular Chitchatting: Exploring the Role of Exosomes as Cardiovascular Risk Factors
Germena G, Zelarayán LC, Hinkel R |
Frontiers in Cell and Developmental Biology | 2022 |
Potential clinical applications of exosomes in the diagnosis, treatment, and prognosis of cardiovascular diseases: a narrative review
Chen X, Luo Q |
Annals of translational medicine | 2022 |
Research Progress on Transorgan Regulation of the Cardiovascular and Motor System through Cardiogenic Exosomes
Gao H, Zhang L, Wang Z, Yan K, Zhao L, Xiao W |
International journal of molecular sciences | 2022 |
Extracellular Vesicles in Cardiovascular Diseases: Diagnosis and Therapy
Zhang X, Wu Y, Cheng Q, Bai L, Huang S, Gao J |
Frontiers in Cell and Developmental Biology | 2022 |
Extracellular Vesicles and Thrombogenicity in Atrial Fibrillation
Berezin AE, Berezin AA |
International journal of molecular sciences | 2022 |
The Roles of Cardiac Fibroblasts and Endothelial Cells in Myocarditis
Xuan Y, Chen C, Wen Z, Wang DW |
Frontiers in Cardiovascular Medicine | 2022 |
Exosome Processing and Characterization Approaches for Research and Technology Development
Lai JJ, Chau ZL, Chen S, Hill JJ, Korpany KV, Liang N, Lin L, Lin Y, Liu JK, Liu Y, Lunde R, Shen W |
Advanced Science | 2022 |
Plasma Exosome miRNAs Profile in Patients With ST-Segment Elevation Myocardial Infarction
Guan R, Zeng K, Zhang B, Gao M, Li J, Jiang H, Liu Y, Qiang Y, Liu Z, Li J, Yang Y |
Frontiers in Cardiovascular Medicine | 2022 |
Exosomal microRNAs miR-30d-5p and miR-126a-5p Are Associated with Heart Failure with Preserved Ejection Fraction in STZ-Induced Type 1 Diabetic Rats
Huang JP, Chang CC, Kuo CY, Huang KJ, Sokal EM, Chen KH, Hung LM |
International journal of molecular sciences | 2022 |
Effects of exosomes on adult hippocampal neurogenesis and neuropsychiatric disorders.
Zhang Y, Xu C |
Molecular Biology Reports | 2022 |
MicroRNAs in hypertrophic cardiomyopathy: pathogenesis, diagnosis, treatment potential and roles as clinical biomarkers.
Luo F, Liu W, Bu H |
Heart Failure Reviews | 2022 |
The Peripheral Circulating Exosomal microRNAs Related to Central Inflammation in Chronic Heart Failure.
Xiao YC, Wang W, Gao Y, Li WY, Tan X, Wang YK, Wang WZ |
Journal of Cardiovascular Translational Research | 2022 |
Lim Domain Binding 3 (Ldb3) Identified as a Potential Marker of Cardiac Extracellular Vesicles.
Abou Zeid F, Charrier H, Beseme O, Michel JB, Mulder P, Amouyel P, Pinet F, Turkieh A |
International journal of molecular sciences | 2022 |
Exosomal microRNAs in diabetic heart disease
Chandrasekera D, Katare R |
Cardiovascular Diabetology | 2022 |
Exosome-Derived Circ_0094343 Promotes Chemosensitivity of Colorectal Cancer Cells by Regulating Glycolysis via the miR-766-5p/TRIM67 Axis
Li C, Li X |
Contrast Media & Molecular Imaging | 2022 |
Extracellular Vesicles, Inflammation, and Cardiovascular Disease
Akhmerov A, Parimon T |
Cells | 2022 |
Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice
McLendon JM, Zhang X, Matasic DS, Kumar M, Koval OM, Grumbach IM, Sadayappan S, London B, Boudreau RL |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2022 |
Prophylactic exercise-derived circulating exosomal miR-125a-5p promotes endogenous revascularization after hindlimb ischemia by targeting endothelin converting enzyme 1
Qiu X, Zhou J, Xu Y, Liao L, Yang H, Xiang Y, Zhou Z, Sun Q, Chen M, Zhang J, Wu W, Zhu L, You B, He L, Luo Y, Li Z, Li C, Bai Y |
Frontiers in Cardiovascular Medicine | 2022 |
miR‐3184‐3p enriched in cerebrospinal fluid exosomes contributes to progression of glioma and promotes M2‐like macrophage polarization
Xu H, Li M, Pan Z, Zhang Z, Gao Z, Zhao R, Li B, Qi Y, Qiu W, Guo Q, Zhang S, Fan Y, Zhao S, Wang S, Guo X, Deng L, Xue H, Li G |
Cancer Science | 2022 |
Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC.
Wang Q, Wang MW, Sun YY, Hu XY, Geng PP, Shu H, Wang XN, Wang H, Zhang JF, Cheng HQ, Wang W, Jin XC |
Acta Pharmacologica Sinica | 2022 |
Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation.
Hao H, Yan S, Zhao X, Han X, Fang N, Zhang Y, Dai C, Li W, Yu H, Gao Y, Wang D, Gao Q, Duan Y, Yuan Y, Li Y |
Journal of Translational Medicine | 2022 |
Role of Exosomes in Pharyngucutaneous Fistula After Total Laryngectomy
Chen L, Wang M, Zhong Z, Liu B, Zhang W, Zhu B, Jiao C, Yu C, Guan B |
International Journal of Nanomedicine | 2022 |
Exosomes and Exosomal Cargos: A Promising World for Ventricular Remodeling Following Myocardial Infarction
Fang J, Zhang Y, Chen D, Zheng Y, Jiang J |
International Journal of Nanomedicine | 2022 |
Extracellular vesicles: Emerging tools as therapeutic agent carriers
Liu S, Wu X, Chandra S, Lyon C, Ning B, jiang L, Fan J, Hu TY |
Acta pharmaceutica Sinica. B | 2022 |
Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
Yao J, Cai L, Chen Y, Zhang J, Zhuang W, Liang J, Li H |
Cell communication and signaling : CCS | 2022 |
Computational analysis of serum-derived extracellular vesicle miRNAs in juvenile sheep model of single stage Fontan procedure.
Park HJ, Kelly JM, Hoffman JR, Takaesu F, Schwartzman W, Ulziibayar A, Kitsuka T, Heuer E, Yimit A, Malbrue R, Anderson C, Morrison A, Naguib A, Mckee C, Harrison A, Boe B, Armstrong A, Salavitabar A, Yates A, Shinoka T, Carrillo S, Breuer CK, Davis ME |
2022 | |
Regulation of autophagy of the heart in ischemia and reperfusion.
Popov SV, Mukhomedzyanov AV, Voronkov NS, Derkachev IA, Boshchenko AA, Fu F, Sufianova GZ, Khlestkina MS, Maslov LN |
Apoptosis : an international journal on programmed cell death | 2022 |
Intermittent hypoxia BMSCs-derived exosomal miR-31-5p promotes lung adenocarcinoma development via WDR5-induced epithelial mesenchymal transition.
Ren J |
Sleep & breathing = Schlaf & Atmung | 2022 |
Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma.
Farhat W, Yeung V, Kahale F, Parekh M, Cortinas J, Chen L, Ross AE, Ciolino JB |
2022 | |
Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential
Khan FB, Uddin S, Elderdery AY, Goh KW, Ming LC, Ardianto C, Palakot AR, Anwar I, Khan M, Owais M, Huang CY, Daddam JR, Khan MA, Shoaib S, Khursheed M, Reshadat S, Khayat Kashani HR, Mirza S, Khaleel AA, Ayoub MA |
Cells | 2022 |
RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration.
Di Liegro CM, Schiera G, Schirò G, Di Liegro I |
International journal of molecular sciences | 2022 |
MicroRNAs as novel peripheral markers for suicidality in patients with major depressive disorder
Stapel B, Xiao K, Gorinski N, Schmidt K, Pfanne A, Fiedler J, Richter I, Vollbrecht AL, Thum T, Kahl KG, Ponimaskin E |
Frontiers in Psychiatry | 2022 |
Specific microRNAs and heart failure: time for the next step toward application?
Sigutova R, Evin L, Stejskal D, Ploticova V, Svagera Z |
2022 | |
The unexpected versatility of ALP/Enigma family proteins
Fisher LA, Schöck F |
Frontiers in Cell and Developmental Biology | 2022 |
Epigenetics and Gut Microbiota Crosstalk: A potential Factor in Pathogenesis of Cardiovascular Disorders
Mehta V, Nagu P, Inbaraj BS, Sharma M, Parashar A, Sridhar K |
Bioengineering | 2022 |
Endothelial Cell GATA2 Modulates the Cardiomyocyte Stress Response through the Regulation of Two Long Non-Coding RNAs
Froese N, Szaroszyk M, Korf-Klingebiel M, Koch K, Schmitto JD, Geffers R, Hilfiker-Kleiner D, Riehle C, Wollert KC, Bauersachs J, Heineke J |
Biology | 2022 |
Extracellular Vesicles' Role in the Pathophysiology and as Biomarkers in Cystic Fibrosis and COPD.
Di Gioia S, Daniello V, Conese M |
International journal of molecular sciences | 2022 |
Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction
Zhan J, Jin K, Ding N, Zhou Y, Hu G, Yuan S, Xie R, Wen Z, Chen C, Li H, Wang DW |
2022 | |
Functional Roles of Exosomes in Allergic Contact Dermatitis
Song B, Chen Q, Li Y, Zhan S, Zhao R, Shen X, Liu M, Tong C |
Journal of Microbiology and Biotechnology | 2022 |
Extracellular Vesicles in the Glioblastoma Microenvironment: A Diagnostic and Therapeutic Perspective
Russo MN, Whaley LA, Norton ES, Zarco N, Guerrero-Cázares H |
Molecular Aspects of Medicine | 2022 |
Can Extracellular Vesicles as Drug Delivery Systems Be a Game Changer in Cardiac Disease?
Okamura A, Yoshioka Y, Saito Y, Ochiya T |
Pharmaceutical Research | 2022 |
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
Phang RJ, Ritchie RH, Hausenloy DJ, Lees JG, Lim SY |
Cardiovascular Research | 2022 |
Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy
Lu QB, Ding Y, Liu Y, Wang ZC, Wu YJ, Niu KM, Li KX, Zhang JR, Sun HJ |
Journal of Advanced Research | 2022 |
MicroRNAs in cardiovascular diseases
Li H, Zhan J, Chen C, Wang D |
2022 | |
MicroRNA-21通过自噬影响疾病的研究进展
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2022 | |
Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development
Caturano A, Vetrano E, Galiero R, Salvatore T, Docimo G, Epifani R, Alfano M, Sardu C, Marfella R, Rinaldi L, Sasso FC |
2022 | |
Extracellular vesicles and exosomes generated from cystic renal epithelial cells promote cyst growth in autosomal dominant polycystic kidney disease
H Ding, LX Li, PC Harris, J Yang, X Li |
Nature Communications | 2021 |
The Impact of microRNAs in Renin–Angiotensin-System-Induced Cardiac Remodelling
M Adamcova, I Kawano, F Simko |
International journal of molecular sciences | 2021 |
New Frontiers: Extracellular Vesicles
S Mathivanan, P Fonseka, C Nedeva, I Atukorala |
2021 | |
Myofibroblast-Derived Exosome Induce Cardiac Endothelial Cell Dysfunction
P Ranjan, R Kumari, SK Goswami, J Li, H Pal, Z Suleiman, Z Cheng, P Krishnamurthy, R Kishore, SK Verma |
Frontiers in Cardiovascular Medicine | 2021 |
Connecting different heart diseases through intercellular communication
T Martins-Marques |
Biology Open | 2021 |
Cardiac Fibrosis: Cellular Effectors, Molecular Pathways, and Exosomal Roles
W Jiang, Y Xiong, X Li, Y Yang |
Frontiers in Cardiovascular Medicine | 2021 |
Cardiac Exosomes in Ischemic Heart Disease—A Narrative Review
Ø Røsand, MA Høydal |
Diagnostics | 2021 |
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function
M Ciccarelli, D Dawson, I Falcao-Pires, M Giacca, N Hamdani, S Heymans, A Hooghiemstra, A Leeuwis, D Hermkens, CG Tocchetti, J van der Velden, S Zacchigna, T Thum |
Cardiovascular Research | 2021 |
Adding a “Notch” to Cardiovascular Disease Therapeutics: A MicroRNA-Based Approach
L Marracino, F Fortini, E Bouhamida, F Camponogara, P Severi, E Mazzoni, S Patergnani, E DAniello, R Campana, P Pinton, F Martini, M Tognon, G Campo, R Ferrari, FV Sega, P Rizzo |
Frontiers in Cell and Developmental Biology | 2021 |
Regulation of Nrf2 signaling pathway in heart failure: Role of extracellular vesicles and non-coding RNAs
C Tian, L Gao, IH Zucker |
Free radical biology & medicine | 2021 |
Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies
N Hamdani, S Costantino, A Mügge, D Lebeche, C Tschöpe, T Thum, F Paneni |
European Heart Journal | 2021 |
miRNomics: MicroRNA Biology and Computational Analysis
J Allmer, M Yousef |
2021 | |
Extracellular vesicle interplay in cardiovascular pathophysiology
S Saheera, VP Jani, KW Witwer, S Kutty |
American journal of physiology. Heart and circulatory physiology | 2021 |
Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease
CK Nonaka, GL Sampaio, L de Aragão França, BR Cavalcante, KN Silva, R Khouri, FG Torres, CS Meira, E de Souza Santos, CT Macedo, BD Paredes, VP Rocha, SR Rogatto, RR dos Santos, BS de Freitas Souza, MB Soares |
International journal of molecular sciences | 2021 |
miR-21 in Human Cardiomyopathies
S Surina, RA Fontanella, L Scisciola, R Marfella, G Paolisso, M Barbieri |
Frontiers in Cardiovascular Medicine | 2021 |
The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection
R Mirzaei, S Babakhani, P Ajorloo, RH Ahmadi, SR Hosseini-Fard, H Keyvani, Y Ahmadyousefi, A Teimoori, F Zamani, S Karampoor, R Yousefimashouf |
Molecular Medicine | 2021 |
Extracellular Vesicles and Their Relationship with the Heart–Kidney Axis, Uremia and Peritoneal Dialysis
CA Azevedo, RS da Cunha, CV Junho, JV da Silva, AN Moreno-Amaral, TP de Moraes, MS Carneiro-Ramos, AE Stinghen |
Toxins | 2021 |
Therapeutic and Diagnostic Translation of Extracellular Vesicles in Cardiovascular Diseases: Roadmap to the Clinic
S Sahoo, M Adamiak, P Mathiyalagan, F Kenneweg, S Kafert-Kasting, T Thum |
Circulation | 2021 |
Cardiomyocyte-produced miR-339-5p mediates pathology in Duchenne muscular dystrophy cardiomyopathy
M Gartz, M Beatka, MJ Prom, JL Strande, MW Lawlor |
Human Molecular Genetics | 2021 |
Cellular signaling cross-talk between different cardiac cell populations: an insight into the role of exosomes in the heart diseases and therapy
BY Nguyen, T Azam, X Wang |
American journal of physiology. Heart and circulatory physiology | 2021 |
A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine
KT Wagner, M Radisic |
2021 | |
Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
AS Jadli, A Parasor, KP Gomes, R Shandilya, VB Patel |
Frontiers in Cardiovascular Medicine | 2021 |
Mesenchymal stem-cell-derived exosomal miR-145 inhibits atherosclerosis by targeting JAM-A
W Yang, R Yin, X Zhu, S Yang, J Wang, Z Zhou, X Pan, A Ma |
Molecular Therapy — Nucleic Acids | 2021 |
Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts
X Sun, H Zhu, W Li, L Zhao, W Li, X Li, Z Xie, Y Cao |
PloS one | 2021 |
Extracellular vesicles from anoxia preconditioned mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury
C Mao, D Li, E Zhou, E Gao, T Zhang, S Sun, L Gao, Y Fan, C Wang |
Aging | 2021 |
Clinical applications for exosomes: Are we there yet?
D Perocheau, L Touramanidou, S Gurung, P Gissen, J Baruteau |
British Journal of Pharmacology | 2021 |
MicroRNA-29a-3p delivery via exosomes derived from engineered human mesenchymal stem cells exerts tumour suppressive effects by inhibiting migration and vasculogenic mimicry in glioma
Z Zhang, X Guo, X Guo, R Yu, M Qian, S Wang, X Gao, W Qiu, Q Guo, J Xu, Z Chen, H Wang, Y Qi, R Zhao, H Xue, G Li |
Aging | 2021 |
GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion
X Yang, Y Chen, Y Zhou, C Wu, Q Li, J Wu, WW Hu, WQ Zhao, W Wei, CP Wu, JT Jiang, M Ji |
Oncogene | 2021 |
Connexins in the Heart: Regulation, Function and Involvement in Cardiac Disease
A Rodríguez-Sinovas, JA Sánchez, L Valls-Lacalle, M Consegal, I Ferreira-González |
International journal of molecular sciences | 2021 |
The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease
L Ohayon, X Zhang, P Dutta |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2021 |
Extracellular Vesicles—The Next Frontier in Endocrinology
AD Gupta, N Krawczynska, ER Nelson |
Endocrinology | 2021 |
miR‑320a in serum exosomes promotes myocardial fibroblast proliferation via regulating the PIK3CA/Akt/mTOR signaling pathway in HEH2 cells
QG Wang, B Cheng, YZ He, LJ Li, Y Ling, G Luo, L Wang, S Liang, Y Zhang |
Experimental and therapeutic medicine | 2021 |
Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean
Y Gong, X Wei, W Sun, X Ren, J Chen, JJ Aweya, H Ma, KG Chan, Y Zhang, S Li, NM dos Santos |
PLoS pathogens | 2021 |
Exosomes: Potential Disease Biomarkers and New Therapeutic Targets
MI Mosquera-Heredia, LC Morales, OM Vidal, E Barceló, C Silvera-Redondo, JI Vélez, P Garavito-Galofre |
Biomedicines | 2021 |
Changes in ion channel expression and function associated with cardiac arrhythmogenic remodeling by Sorbs2
LL Qian, X Sun, J Yang, XL Wang, MJ Ackerman, RX Wang, X Xu, HC Lee, T Lu |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2021 |
Macrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis
NN Sun, Y Zhang, WH Huang, BJ Zheng, SY Jin, X Li, Y Meng |
Chinese Medical Journal | 2021 |
Ventricular Arrhythmias in Ischemic Cardiomyopathy—New Avenues for Mechanism-Guided Treatment
M Amoni, E Dries, S Ingelaere, D Vermoortele, HL Roderick, P Claus, R Willems, KR Sipido |
Cells | 2021 |
MSCs-Derived Extracellular Vesicles Carrying miR-212-5p Alleviate Myocardial Infarction-Induced Cardiac Fibrosis via NLRC5/VEGF/TGF-β1/SMAD Axis
Y Wu, W Peng, M Fang, M Wu, M Wu |
Journal of Cardiovascular Translational Research | 2021 |
Extracellular vesicles—incorporated microRNA signature as biomarker and diagnosis of prediabetes state and its complications
N Alexandru, A Procopciuc, A Vîlcu, IK Comariţa, E Bӑdilӑ, A Georgescu |
Reviews in Endocrine and Metabolic Disorders | 2021 |
Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction
Y Zhang, Z Cai, Y Shen, Q Lu, W Gao, X Zhong, K Yao, J Yuan, H Liu |
Journal of nanobiotechnology | 2021 |
Myeloid MKL1 Disseminates Cues to Promote Cardiac Hypertrophy in Mice
L Liu, Q Zhao, L Lin, G Yang, L Yu, L Zhuo, Y Yang, Y Xu |
Frontiers in Cell and Developmental Biology | 2021 |
Roles of Exosomes in Cardiac Fibroblast Activation and Fibrosis
J Hohn, W Tan, A Carver, H Barrett, W Carver |
Cells | 2021 |
In Vivo Characterization of Endogenous Cardiovascular Extracellular Vesicles in Larval and Adult Zebrafish
A Scott, LS Ballesteros, M Bradshaw, , A Power, J Lorriman, J Love, D Paul, A Herman, C Emanueli, RJ Richardson |
Arteriosclerosis, thrombosis, and vascular biology | 2021 |
Pain relief and cartilage repair by Nanofat against osteoarthritis: preclinical and clinical evidence
Z Chen, Y Ge, L Zhou, T Li, B Yan, J Chen, J Huang, W Du, S Lv, P Tong, L Shan |
Stem Cell Research & Therapy | 2021 |
A meta-analysis of microRNA expression profiling studies in heart failure
A Gholaminejad, N Zare, N Dana, D Shafie, A Mani, SH Javanmard |
Heart Failure Reviews | 2021 |
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Y Yin, H Chen, Y Wang, L Zhang, X Wang |
Journal of Extracellular Vesicles | 2021 |
Extracellular vesicles as mediators and markers of acute organ injury: current concepts
B Weber, N Franz, I Marzi, D Henrich, L Leppik |
European Journal of Trauma and Emergency Surgery | 2021 |
MicroRNA-21-containing microvesicles from tubular epithelial cells promote cardiomyocyte hypertrophy
J Di, M Yang, H Zhou, M Li, J Zhao |
Renal Failure | 2021 |
Exosomal microRNAs: Pleiotropic Impacts on Breast Cancer Metastasis and Their Clinical Perspectives
LB Tang, SX Ma, ZH Chen, QY Huang, LY Wu, Y Wang, RC Zhao, LX Xiong |
Biology : open access journal | 2021 |
The exosome journey: from biogenesis to uptake and intracellular signalling
S Gurung, D Perocheau, L Touramanidou, J Baruteau |
Cell Communication and Signaling | 2021 |
Extracellular vesicles in cardiovascular disease: Biological functions and therapeutic implications
C Han, J Yang, J Sun, G Qin |
Pharmacology & Therapeutics | 2021 |
Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
C Liu, S Chen, H Zhang, Y Chen, Q Gao, Z Chen, Z Liu, J Wang |
Journal of Zhejiang University SCIENCE B | 2021 |
Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine
MD Hade, CN Suire, Z Suo |
Cells | 2021 |
Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease
F Nikdoust, M Pazoki, M Mohammadtaghizadeh, MK Aghaali, M Amrovani |
Cardiovascular Toxicology | 2021 |
The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction
X Zhang, S Yuan, H Li, J Zhan, F Wang, J Fan, X Nie, Y Wang, Z Wen, Y Chen, C Chen, DW Wang |
Signal Transduction and Targeted Therapy | 2021 |
Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury
X Ge, Q Meng, L Wei, J Liu, M Li, X Liang, F Lin, Y Zhang, Y Li, Z Liu, H Fan, X Zhou |
Journal of Extracellular Vesicles | 2021 |
Microglial Exosome miR-7239-3p Promotes Glioma Progression by Regulating Circadian Genes
X Li, J Guan, Z Jiang, S Cheng, W Hou, J Yao, Z Wang |
Neuroscience Bulletin | 2021 |
Regional Heterogeneity of Perivascular Adipose Tissue: Morphology, Origin, and Secretome
X Li, Z Ma, YZ Zhu |
Frontiers in pharmacology | 2021 |
Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications
F Prattichizzo, G Matacchione, A Giuliani, J Sabbatinelli, F Olivieri, P de Candia, VD Nigris, A Ceriello |
Theranostics | 2021 |
Potential of exosomes as diagnostic biomarkers and therapeutic carriers for doxorubicin-induced cardiotoxicity
C Tian, Y Yang, B Bai, S Wang, M Liu, RC Sun, T Yu, X Chu |
International journal of biological sciences | 2021 |
SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart
N Valkov, A Das, NR Tucker, G Li, AM Salvador, MD Chaffin, GP Junior, I Kur, P Gokulnath, O Ziegler, A Yeri, S Lu, A Khamesra, C Xiao, R Rodosthenous, S Srinivasan, V Toxavidis, J Tigges, LC Laurent, S Momma, R Kitchen, P Ellinor, I Ghiran, S Das |
Life science alliance | 2021 |
Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo
X Zhou, S Zhao, W Li, Y Ruan, R Yuan, J Ning, K Jiang, J Xie, X Yao, H Li, C Li, T Rao, W Yu, F Cheng |
International journal of biological sciences | 2021 |
Targeted delivery of extracellular vesicles in heart injury
P Chen, L Wang, X Fan, X Ning, B Yu, C Ou, M Chen |
Theranostics | 2021 |
Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction
Z Liao, Y Chen, C Duan, K Zhu, R Huang, H Zhao, M Hintze, Q Pu, Z Yuan, L Lv, H Chen, B Lai, S Feng, X Qi, D Cai |
Theranostics | 2021 |
Hallmarks of exosomes
N Dilsiz |
Future Science OA | 2021 |
SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia
Z Chen, S Zhou, J Li, H Li, C Huang, Q Guo, T Zhang, B Yang, C Tu, C Guo, D Zhang |
Stem Cells International | 2021 |
An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary
J Xiong, H Zhang, B Zeng, J Liu, J Luo, T Chen, J Sun, , Y Zhang |
Frontiers in Genetics | 2021 |
Impact of the Main Cardiovascular Risk Factors on Plasma Extracellular Vesicles and Their Influence on the Heart’s Vulnerability to Ischemia-Reperfusion Injury
M Majka, M Kleibert, M Wojciechowska |
Cells | 2021 |
Potential Applications and Functional Roles of Exosomes in Cardiometabolic Disease
S Ayala-Mar, B Rodríguez-Morales, P Chacón-Ponce, J González-Valdez |
Pharmaceutics | 2021 |
Extracellular Vesicles: Potential Role in Remote Signaling and Inflammation in Trypanosoma cruzi-Triggered Disease
L Dantas-Pereira, R Menna-Barreto, J Lannes-Vieira |
Frontiers in Cell and Developmental Biology | 2021 |
Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo
V James, Z Nizamudeen, D Lea, T Dottorini, T Holmes, B Johnson, K Arkill, C Denning, J Smith |
Stem Cells and Development | 2021 |
Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats
Zaazaa AM, Abd El-Motelp BA, Ali NA, Youssef AM, Sayed MA, Mohamed SH |
Heliyon | 2021 |
Extracellular vesicles: Potential impact on cardiovascular diseases.
Yang J, Zou X, Jose PA, Zeng C |
Advances in Clinical Chemistry | 2021 |
Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy
M Gartz, CW Lin, MA Sussman, MW Lawlor, JL Strande |
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FEBS Letters | 2018 |
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN
X Nie, J Fan, H Li, Z Yin, Y Zhao, B Dai, N Dong, C Chen, DW Wang |
Molecular Therapy — Nucleic Acids | 2018 |
Noncoding RNAs in Cardiac Hypertrophy
Y Li, Y Liang, Y Zhu, Y Zhang, Y Bei |
Journal of Cardiovascular Translational Research | 2018 |
Protective effects of human induced pluripotent stem cell‑derived exosomes on high glucose‑induced injury in human endothelial cells
Q Ding, R Sun, P Wang, H Zhang, M Xiang, D Meng, N Sun, A Chen, S Chen |
Experimental and therapeutic medicine | 2018 |
Stem cell-derived exosomes - an emerging tool for myocardial regeneration
E Lazar, T Benedek, S Korodi, N Rat, J Lo, I Benedek |
World journal of stem cells | 2018 |
Regulation of insulin resistance and type II diabetes by hepatitis C virus infection: A driver function of circulating miRNAs
A Singhal, A Agrawal, J Ling |
Journal of Cellular and Molecular Medicine | 2018 |
Exosomal microRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue ContractilityNovelty and Significance
J Mayourian, DK Ceholski, PA Gorski, P Mathiyalagan, JF Murphy, SI Salazar, F Stillitano, JM Hare, S Sahoo, RJ Hajjar, KD Costa |
Circulation research | 2018 |
miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy
JG Oh, S Watanabe, A Lee, PA Gorski, P Lee, D Jeong, L Liang, Y Liang, A Baccarini, S Sahoo, BD Brown, RJ Hajjar, C Kho |
Circulation research | 2018 |
The harsh microenvironment in infarcted heart accelerates transplanted bone marrow mesenchymal stem cells injury: the role of injured cardiomyocytes-derived exosomes
M Hu, G Guo, Q Huang, C Cheng, R Xu, A Li, N Liu, S Liu |
Cell Death and Disease | 2018 |
New Insights into the Role of Exosomes in the Heart After Myocardial Infarction
N Li, L Rochette, Y Wu, N Rosenblatt-Velin |
Journal of Cardiovascular Translational Research | 2018 |
Stem Cell-Derived Exosome in Cardiovascular Diseases: Macro Roles of Micro Particles
Y Yuan, W Du, J Liu, W Ma, L Zhang, Z Du, B Cai |
Frontiers in pharmacology | 2018 |
Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair
VN Garikipati, F Shoja-Taheri, ME Davis, R Kishore |
Circulation research | 2018 |
Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure
Y Zhao, Y Li, L Tong, X Liang, H Zhang, L Li, G Fan, Y Wang |
Frontiers in physiology | 2018 |
Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions
H Jin, DY Li, E Chernogubova, C Sun, A Busch, SM Eken, P Saliba-Gustafsson, H Winter, G Winski, U Raaz, IN Schellinger, N Simon, R Hegenloh, LP Matic, M Jagodic, E Ehrenborg, J Pelisek, HH Eckstein, U Hedin, A Backlund, L Maegdefessel |
Molecular Therapy | 2018 |
Exosomes as a novel pathway for regulating development and diseases of the skin (Review)
Y Liu, H Wang, J Wang |
Biomedical Reports | 2018 |
MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress
J Yuan, H Liu, W Gao, L Zhang, Y Ye, L Yuan, Z Ding, J Wu, L Kang, X Zhang, X Wang, G Zhang, H Gong, A Sun, X Yang, R Chen, Z Cui, J Ge, Y Zou |
Theranostics | 2018 |
The Destiny of Glucose from a MicroRNA Perspective
P Mirra, C Nigro, I Prevenzano, A Leone, GA Raciti, P Formisano, F Beguinot, C Miele |
Frontiers in Endocrinology | 2018 |
The Secret Life of Exosomes
E Marbán |
Journal of the American College of Cardiology | 2018 |
Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure
C Tian, L Gao, MC Zimmerman, IH Zucker |
American journal of physiology. Heart and circulatory physiology | 2018 |
Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?
D de Gonzalo-Calvo, A Vea, C Bär, J Fiedler, LS Couch, C Brotons, V Llorente-Cortes, T Thum |
European Heart Journal | 2018 |
The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research
JC Gross, LC Zelarayán |
Frontiers in Cardiovascular Medicine | 2018 |
Smooth muscle cells differentiated from mesenchymal stem cells are regulated by microRNAs and suitable for vascular tissue grafts
W Gu, X Hong, AL Bras, WN Nowak, SI Bhaloo, J Deng, Y Xie, Y Hu, XZ Ruan, Q Xu |
The Journal of biological chemistry | 2018 |
Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics
M Adamiak, S Sahoo |
Molecular Therapy | 2018 |
Role of Exosomal MicroRNAs and myomiRs in the Development of Cancer Cachexia-Associated Muscle Wasting
R Marinho, PS Alcântara, JP Ottoch, M Seelaender |
Frontiers in Nutrition | 2018 |
Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways
X Guo, W Qiu, Q Liu, M Qian, S Wang, Z Zhang, X Gao, Z Chen, H Xue, G Li |
Oncogene | 2018 |
MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells
W You, X Zhang, M Ji, Y Yu, C Chen, Y Xiong, Y Liu, Y Sun, C Tan, H Zhang, J Li, W Chen, R Li |
International journal of biological sciences | 2018 |
Examining the Paracrine Effects of Exosomes in Cardiovascular Disease and Repair
M Gartz, JL Strande |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
Cardiac progenitor cell‑derived exosomes promote H9C2 cell growth via Akt/mTOR activation
S Li, J Jiang, Z Yang, Z Li, X Ma, X Li |
International journal of molecular medicine | 2018 |
Distinct Anti-Fibrotic Effects of Exosomes Derived from Endothelial Colony-Forming Cells Cultured Under Normoxia and Hypoxia
WH Liu, HF Zhang, JT Mai, ZT Chen, TC Huang, SH Wang, YX Chen, JF Wang |
Medical science monitor : international medical journal of experimental and clinical research | 2018 |
Exosomal 15-LO2 mediates hypoxia-induced pulmonary artery hypertension in vivo and in vitro
M Zhang, W Xin, C Ma, H Zhang, M Mao, Y Liu, X Zheng, L Zhang, X Yu, H Li, D Zhu |
Cell Death and Disease | 2018 |
Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study
D de Gonzalo-Calvo, G Cediel, C Bär, J Núñez, E Revuelta-Lopez, J Gavara, C Ríos-Navarro, V Llorente-Cortes, V Bodí, T Thum, A Bayes-Genis |
Scientific Reports | 2018 |
Evaluation of the cardioprotective potential of extracellular vesicles – a systematic review and meta-analysis
S Wendt, A Goetzenich, C Goettsch, C Stoppe, C Bleilevens, S Kraemer, C Benstoem |
Scientific Reports | 2018 |
Extracellular vesicles in liver disease and beyond
L Morán, FJ Cubero |
World journal of gastroenterology : WJG | 2018 |
A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
X Ma, Y Ding, Y Wang, X Xu |
Journal of visualized experiments : JoVE | 2018 |
Heterocellularity and Cellular Cross-Talk in the Cardiovascular System
F Perbellini, SA Watson, I Bardi, CM Terracciano |
Frontiers in Cardiovascular Medicine | 2018 |
Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation
RA Paiva, T Martins-Marques, K Jesus, T Ribeiro-Rodrigues, M Zuzarte, A Silva, L Reis, M da Silva, P Pereira, P Vader, JP Sluijter, L Gonçalves, MT Cruz, H Girao |
Journal of Cellular and Molecular Medicine | 2018 |
Exosomes: Basic Biology and Technological Advancements Suggesting Their Potential as Ischemic Heart Disease Therapeutics
M Shanmuganathan, J Vughs, M Noseda, C Emanueli |
Frontiers in physiology | 2018 |
MicroRNA-21 is Associated with the Severity of Right Ventricular Dysfunction in Patients with Hypoxia-Induced Pulmonary Hypertension
Wei-Ting Chang, Chih-Hsin Hsu, Tzu-Ling Huang, Ying-Ching Tsai, Chun-Yen Chiang, Zhih-Cherng Chen, Jhih-Yuan Shih |
ACTA CARDIOL SIN | 2018 |
MicroRNA expression profile during different conditions of hypoxia
D Lacedonia, G Scioscia, GP Palladino, C Gallo, GE Carpagnano, R Sabato, MP Barbaro |
Oncotarget | 2018 |
Atherogenesis and Metabolic Dysregulation in LDL Receptor Knockout Rats
Srinivas Dwarakanath Sithu, Marina V. Malovichko, Krista A Riggs, Nalinie S Wickramasinghe, Millicent G Winner, Abhinav Agarwal, Rihab E Hamed-Berair, Anuradha Kalani, Daniel W Riggs, Aruni Bhatnagar, Sanjay Srivastava |
JCI Insight | 2017 |
miR-21 is Associated with Fibrosis and Right Ventricular Failure
Sushma Reddy, Dong-Qing Hu, Mingming Zhao, Eddie Blay, Nefthi Sandeep, Sang-Ging Ong, Gwanghyun Jung, Kristina B Kooiker, Michael Coronado, Giovanni Fajardo, Daniel Bernstein |
JCI Insight | 2017 |
Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium
P Kong, AV Shinde, Y Su, I Russo, B Chen, A Saxena, SJ Conway, JM Graff, NG Frangogiannis |
Circulation | 2017 |
Extracellular Vesicles as Protagonists of Diabetic Cardiovascular Pathology
D Gustafson, S Veitch, JE Fish |
Frontiers in Cardiovascular Medicine | 2017 |
Endothelial- and Immune Cell-Derived Extracellular Vesicles in the Regulation of Cardiovascular Health and Disease
F Jansen, Q Li, A Pfeifer, N Werner |
JACC: Basic to Translational Science | 2017 |
MicroRNA as a Therapeutic Target in Cardiac Remodeling
C Chen, M Ponnusamy, C Liu, J Gao, K Wang, P Li |
BioMed Research International | 2017 |
Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis
C Beltrami, M Besnier, S Shantikumar, AI Shearn, C Rajakaruna, A Laftah, F Sessa, G Spinetti, E Petretto, GD Angelini, C Emanueli |
Molecular Therapy | 2017 |
Non-coding RNAs in cardiac hypertrophy: Non-coding RNAs in cardiac hypertrophy
L Ottaviani, PA da Martins |
The Journal of Physiology | 2017 |
Overexpression of Exosomal Cardioprotective miRNAs Mitigates Hypoxia-Induced H9c2 Cells Apoptosis
J Zhang, J Ma, K Long, W Qiu, Y Wang, Z Hu, C Liu, Y Luo, A Jiang, L Jin, Q Tang, X Wang, X Li, M Li |
International journal of molecular sciences | 2017 |
TGFβ1 in fibroblasts-derived exosomes promotes epithelial-mesenchymal transition of ovarian cancer cells
W Li, X Zhang, J Wang, M Li, C Cao, J Tan, D Ma, Q Gao |
Oncotarget | 2017 |
MicroRNAs in Atrial Fibrillation: from Expression Signatures to Functional Implications
NW van Berg, M Kawasaki, WR Berger, J Neefs, E Meulendijks, AJ Tijsen, JR de Groot |
Cardiovascular Drugs and Therapy | 2017 |
The Role of MicroRNAs in the Cardiac Response to Exercise
X Liu, C Platt, A Rosenzweig |
Cold Spring Harbor Perspectives in Medicine | 2017 |
Exosomes Generated From iPSC-Derivatives: New Direction for Stem Cell Therapy in Human Heart Diseases
JH Jung, X Fu, PC Yang |
Circulation research | 2017 |
Extracellular Vesicles in Cardiovascular Theranostics
Y Bei, S Das, RS Rodosthenous, P Holvoet, M Vanhaverbeke, MC Monteiro, VV Monteiro, J Radosinska, M Bartekova, F Jansen, Q Li, J Rajasingh, J Xiao |
Theranostics | 2017 |
In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish: Cardiac in vitro models for myocyte and non-myocyte crosstalk
CM Kofron, U Mende |
The Journal of Physiology | 2017 |
Exosomes: A Rising Star in Falling Hearts
JY Xu, GH Chen, YJ Yang |
Frontiers in physiology | 2017 |
Role and Regulation of MicroRNAs in Aldosterone-Mediated Cardiac Injury and Dysfunction in Male Rats
JP Ball, M Syed, RO Marañon, ME Hall, R KC, JF Reckelhoff, LL Cardozo, DG Romero |
Endocrinology | 2017 |
Mechanisms of Fibroblast Activation in the Remodeling Myocardium
AV Shinde, NG Frangogiannis |
Current Pathobiology Reports | 2017 |
Translational Perspective on Epigenetics in Cardiovascular Disease
P der Harst, LJ de Windt, JC Chambers |
Journal of the American College of Cardiology | 2017 |
Exosomes as agents of change in the cardiovascular system
AJ Poe, AA Knowlton |
Journal of Molecular and Cellular Cardiology | 2017 |
Exosomal MicroRNA Transfer Into Macrophages Mediates Cellular PostconditioningClinical Perspective
G Couto, R Gallet, L Cambier, E Jaghatspanyan, N Makkar, JF Dawkins, BP Berman, E Marbán |
Circulation | 2017 |
Beneficial effects of exosomes secreted by cardiac-derived progenitor cells and other cell types in myocardial ischemia
L Barile, G Milano, G Vassalli |
Stem Cell Investigation | 2017 |
The Influence of Extracellular RNA on Cell Behavior in Health, Disease, and Regeneration
L Huleihel, ME Scarritt, SF Badylak |
Current Pathobiology Reports | 2017 |
Characterization of extracellular vesicles derived from cardiac cells in an in vitro model of preconditioning
S Borosch, E Dahmen, C Beckers, C Stoppe, EM Buhl, B Denecke, A Goetzenich, S Kraemer |
Journal of Extracellular Vesicles | 2017 |
Asymmetric RNA Distribution among Cells and Their Secreted Exosomes: Biomedical Meaning and Considerations on Diagnostic Applications
M Ragusa, C Barbagallo, M Cirnigliaro, R Battaglia, D Brex, A Caponnetto, D Barbagallo, CD Pietro, M Purrello |
Frontiers in Molecular Biosciences | 2017 |
Exosomes: new molecular targets of diseases
S Samanta, S Rajasingh, N Drosos, Z Zhou, B Dawn, J Rajasingh |
Acta Pharmacologica Sinica | 2017 |
Adipose-derived circulating miRNAs regulate gene expression in other tissues
T Thomou, MA Mori, JM Dreyfuss, M Konishi, M Sakaguchi, C Wolfrum, TN Rao, JN Winnay, R Garcia-Martin, SK Grinspoon, P Gorden, CR Kahn |
Nature | 2017 |
MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair
L Shao, Y Zhang, B Lan, J Wang, Z Zhang, L Zhang, P Xiao, Q Meng, Y Geng, X Yu, Y Li |
BioMed Research International | 2017 |
Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7
G Wei, Y Jie, L Haibo, W Chaoneng, H Dong, Z Jianbing, G Junjie, M Leilei, S Hongtao, Z Yunzeng, G Junbo |
Scientific Reports | 2017 |
Extracellular vesicles-mediated transfer of miR-208a/b exaggerate hypoxia/reoxygenation injury in cardiomyocytes by reducing QKI expression
F Wang, Y Yuan, P Yang, X Li |
Molecular and Cellular Biochemistry | 2017 |
Association of serum microRNAs with islet autoimmunity, disease progression and metabolic impairment in relatives at risk of type 1 diabetes
IV Snowhite, G Allende, J Sosenko, RL Pastori, SM Cayetano, A Pugliese |
Diabetologia | 2017 |
Exosomes in Cardiovascular Medicine
IM Dykes |
Cardiology and Therapy | 2017 |
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery
DS Sutaria, J Jiang, OA Elgamal, SM Pomeroy, M Badawi, X Zhu, R Pavlovicz, AC Azevedo-Pouly, J Chalmers, C Li, MA Phelps, TD Schmittgen |
Journal of Extracellular Vesicles | 2017 |
Association of microRNAs with Argonaute proteins in the malaria mosquito Anopheles gambiae after blood ingestion
X Fu, G Dimopoulos, J Zhu |
Scientific Reports | 2017 |
Differential expression of miRNAs in Osborne's ligament of cubital tunnel syndrome
XH Zhou, YM Ren, ZJ Wei, W Lin, BY Fan, S Liu, Y Hao, GD Shi, SQ Feng |
Molecular medicine reports | 2017 |
miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury
J Shi, Y Bei, X Kong, X Liu, Z Lei, T Xu, H Wang, Q Xuan, P Chen, J Xu, L Che, H Liu, J Zhong, JP Sluijter, X Li, A Rosenzweig, J Xiao |
Theranostics | 2017 |
Exosome production and its regulation of EGFR during wound healing in renal tubular cells
X Zhou, W Zhang, Q Yao, H Zhang, G Dong, M Zhang, Y Liu, JK Chen, Z Dong |
American journal of physiology. Renal physiology | 2017 |
Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes
X Jiang, J Sucharov, BL Stauffer, SD Miyamoto, CC Sucharov |
American journal of physiology. Heart and circulatory physiology | 2017 |
Angiogenic Mechanisms of Human CD34 + Stem Cell Exosomes in the Repair of Ischemic HindlimbNovelty and Significance
P Mathiyalagan, Y Liang, D Kim, S Misener, T Thorne, CE Kamide, E Klyachko, DW Losordo, RJ Hajjar, S Sahoo |
Circulation research | 2017 |
Coding and noncoding landscape of extracellular RNA released by human glioma stem cells
Z Wei, AO Batagov, S Schinelli, J Wang, Y Wang, RE Fatimy, R Rabinovsky, L Balaj, CC Chen, F Hochberg, B Carter, XO Breakefield, AM Krichevsky |
Nature Communications | 2017 |
MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure
E Dubois-Deruy, M Cuvelliez, J Fiedler, H Charrier, P Mulder, E Hebbar, A Pfanne, O Beseme, M Chwastyniak, P Amouyel, V Richard, C Bauters, T Thum, F Pinet |
Scientific Reports | 2017 |
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
JP Sluijter, SM Davidson, CM Boulanger, EI Buzás, DP de Kleijn, FB Engel, Z Giricz, DJ Hausenloy, R Kishore, S Lecour, J Leor, R Madonna, C Perrino, F Prunier, S Sahoo, RM Schiffelers, R Schulz, LW Laake, K Ytrehus, P Ferdinandy |
Cardiovascular Research | 2017 |
Sustained apnea induces endothelial activation
L Eichhorn, R DolscheidPommerich, F Erdfelder, MA Ayub, T Schmitz, N Werner, F Jansen |
Clinical Cardiology | 2017 |
Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Liraglutide Alters Bone Marrow Exosome-Mediated miRNA Signal Pathways in Ovariectomized Rats with Type 2 Diabetes
Li J, Fu LZ, Liu L, Xie F, Dai RC |
Medical science monitor : international medical journal of experimental and clinical research | 2017 |
Exosomes and their role in the micro-/macro-environment: a comprehensive review
Javeed N, Mukhopadhyay D |
Journal of Biomedical Research | 2017 |
A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene
Yonghe Ding, Pamela Long, Martijn Bos, Yu-Huan Shih, Xiao Ma, Rhianna Sundsbak, Jianhua Chen, Yiwen Jiang, Liqun Zhao, Xinyang Hu, Jianan Wang, Yongyong Shi, Michael J. Ackerman, Xueying Lin, Stephen Ekker, Margaret Redfield, Timothy Olson, Xiaolei Xu |
JCI Insight | 2016 |
Adipocyte specific loss of PPARγ attenuates cardiac hypertrophy
xi fang, matthew stroud, Kunfu Ouyang, Li Fang, Jianlin Zhang, Nancy Dalton, Yusu Gu, Tongbin Wu, Kirk Peterson, Hsien-Da Huang, Ju Chen, Nanping Wang |
JCI Insight | 2016 |
Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
F Prattichizzo, A Giuliani, VD Nigris, G Pujadas, A Ceka, LL Sala, S Genovese, R Testa, AD Procopio, F Olivieri, A Ceriello |
Diabetes Obesity and Metabolism | 2016 |
The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
TM Mohamed, R Abou-Leisa, N Stafford, A Maqsood, M Zi, S Prehar, F Baudoin-Stanley, X Wang, L Neyses, EJ Cartwright, D Oceandy |
Nature Communications | 2016 |
Cardiac Extracellular Vesicles in Normal and Infarcted Heart
D Chistiakov, A Orekhov, Y Bobryshev |
International journal of molecular sciences | 2016 |
Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy
R Datta, T Bansal, S Rana, K Datta, RD Chaudhuri, M Chawla-Sarkar, S Sarkar |
Molecular and cellular biology | 2016 |
Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
J Li, T Chen, M Xiao, N Li, S Wang, H Su, X Guo, H Liu, F Yan, Y Yang, Y Zhang, P Bu |
Oncotarget | 2016 |
Novel epigenetic-based therapies useful in cardiovascular medicine
C Napoli |
World journal of cardiology | 2016 |
Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
J Wang, O Liew, A Richards, YT Chen |
International journal of molecular sciences | 2016 |
MicroRNAs in heart failure: Non-coding regulators of metabolic function
X Zhang, PC Schulze |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2016 |
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
RG Gourdie, S Dimmeler, P Kohl |
Nature Reviews Drug Discovery | 2016 |
The Living Scar – Cardiac Fibroblasts and the Injured Heart
EA Rog-Zielinska, RA Norris, P Kohl, R Markwald |
Trends in Molecular Medicine | 2016 |
The Functional Pluralism of Fibroblasts in the Infarcted Myocardium
NG Frangogiannis |
Circulation research | 2016 |
More Than Tiny Sacks: Stem Cell Exosomes as Cell-Free Modality for Cardiac Repair
R Kishore, M Khan |
Circulation research | 2016 |
Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4
J Xiao, Y Pan, XH Li, XY Yang, YL Feng, HH Tan, L Jiang, J Feng, XY Yu |
Cell Death and Disease | 2016 |
Exosomes Mediate the Intercellular Communication after Myocardial Infarction
MJ Yuan, T Maghsoudi, T Wang |
International journal of medical sciences | 2016 |
MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 ExpressionHighlights
S Deng, H Wang, C Jia, S Zhu, X Chu, Q Ma, J Wei, E Chen, W Zhu, CJ Macon, DT Jayaweera, DM Dykxhoorn, C Dong |
Arteriosclerosis, thrombosis, and vascular biology | 2016 |
Exosomes: scytales in the damaged heart
L Ottaviani, LJ de Windt, PA da Martins |
Annals of translational medicine | 2016 |
Extracellular vesicles in cardiovascular disease: are they Jedi or Sith?: Extracellular vesicles in cardiovascular disease
X Osteikoetxea, A Németh, BW Sódar, KV Vukman, EI Buzás |
The Journal of Physiology | 2016 |
Identification of a novel PPARβ/δ/miR‐21‐3p axis in UV‐induced skin inflammation
G Degueurce, I D'Errico, C Pich, M Ibberson, F Schütz, A Montagner, M Sgandurra, L Mury, P Jafari, A Boda, J Meunier, R Rezzonico, NC Brembilla, D Hohl, A Kolios, G Hofbauer, I Xenarios, L Michalik |
EMBO Molecular Medicine | 2016 |
Tiny Shuttles for Information Transfer: Exosomes in Cardiac Health and Disease
R Kishore, VN Garikipati, A Gumpert |
Journal of Cardiovascular Translational Research | 2016 |
MicroRNAs, heart failure, and aging: potential interactions with skeletal muscle
KA Murach, JJ McCarthy |
Heart Failure Reviews | 2016 |
A new role under sortilin's belt in cancer
CM Wilson, T Naves, HA Akhrass, F Vincent, B Melloni, F Bonnaud, F Lalloué, MO Jauberteau |
Communicative & integrative biology | 2016 |
miRNAs Regulation and Its Role as Biomarkers in Endometriosis
J Marí-Alexandre, D Sánchez-Izquierdo, J Gilabert-Estellés, M Barceló-Molina, A Braza-Boïls, J Sandoval |
International journal of molecular sciences | 2016 |
Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives
LE León, S Rani, M Fernandez, M Larico, SD Calligaris |
Journal of Diabetes Research | 2016 |
Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology
A Ibrahim, E Marbán |
Annual Review of Physiology | 2016 |
Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-α mediated NF-κB pathway
W Gao, H Liu, J Yuan, C Wu, D Huang, Y Ma, J Zhu, L Ma, J Guo, H Shi, Y Zou, J Ge |
Journal of Cellular and Molecular Medicine | 2016 |
Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery
C Emanueli, AI Shearn, A Laftah, F Fiorentino, BC Reeves, C Beltrami, A Mumford, A Clayton, M Gurney, S Shantikumar, GD Angelini, G Qin |
PloS one | 2016 |
Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy
F Jiang, X Zhou, J Huang, GC Fan |
PloS one | 2016 |
Investigation of Content, Stoichiometry and Transfer of miRNA from Human Neural Stem Cell Line Derived Exosomes
L Stevanato, L Thanabalasundaram, N Vysokov, JD Sinden, C Emanueli |
PloS one | 2016 |
Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes
AJ Kriegel, M Gartz, MZ Afzal, WJ de Lange, JC Ralphe, JL Strande |
Journal of Cardiovascular Translational Research | 2016 |
Microarray analysis reveals altered circulating microRNA expression in mice infected with Coxsackievirus B3
C Sun, L Tong, W Zhao, Y Wang, Y Meng, L Lin, B Liu, Y Zhai, Z Zhong, X Li |
Experimental and therapeutic medicine | 2016 |
Macrophage Foam Cell–Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion
C Niu, X Wang, M Zhao, T Cai, P Liu, J Li, B Willard, L Zu, E Zhou, Y Li, B Pan, F Yang, L Zheng |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2016 |
Micro-RNAs as promising biomarkers in cardiac diseases
M Akodad, M Mericskay, F Roubille |
Annals of translational medicine | 2016 |
Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients
Xu T, Zhou Q, Che L, Das S, Wang L, Jiang J, Li G, Xu J, Yao J, Wang H, Dai Y, Xiao J |
Oncotarget | 2016 |
Advances in Experimental Medicine and Biology
G Santulli |
Advances in experimental medicine and biology | 2015 |
Reducing In-Stent Restenosis
RA McDonald, CA Halliday, AM Miller, LA Diver, RS Dakin, J Montgomery, MW McBride, S Kennedy, JD McClure, KE Robertson, G Douglas, KM Channon, KG Oldroyd, AH Baker |
Journal of the American College of Cardiology | 2015 |
Functions of Autophagy in Pathological Cardiac Hypertrophy
Z Li, J Wang, X Yang |
International journal of biological sciences | 2015 |
Generation of cardiac progenitor cells through epicardial to mesenchymal transition
A Germani, E Foglio, MC Capogrossi, MA Russo, F Limana |
Journal of Molecular Medicine | 2015 |
Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors
G Pironti, RT Strachan, D Abraham, SM Yu, M Chen, W Chen, K Hanada, L Mao, LJ Watson, HA Rockman |
Circulation | 2015 |
MicroRNAs in cardiovascular disease: an introduction for clinicians
SP Romaine, M Tomaszewski, G Condorelli, NJ Samani |
Heart (British Cardiac Society) | 2015 |
MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance
L Deng, FJ Blanco, H Stevens, R Lu, A Caudrillier, M McBride, JD McClure, J Grant, M Thomas, M Frid, K Stenmark, K White, AG Seto, NW Morrell, AC Bradshaw, MR MacLean, AH Baker |
Circulation research | 2015 |
Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling
RA Frieler, RM Mortensen |
Circulation | 2015 |
A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes
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