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New cast for a new era: preclinical cancer drug development revisited
Grit S. Herter-Sprie, … , Andrew L. Kung, Kwok-Kin Wong
Grit S. Herter-Sprie, … , Andrew L. Kung, Kwok-Kin Wong
Published September 3, 2013
Citation Information: J Clin Invest. 2013;123(9):3639-3645. https://doi.org/10.1172/JCI68340.
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Science in Medicine

New cast for a new era: preclinical cancer drug development revisited

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Abstract

Molecularly targeted agents promise to revolutionize therapeutics by reducing morbidity and mortality in patients with cancer. However, despite an urgent need for more effective anticancer compounds, current preclinical drug evaluations largely fail to satisfy the demand. New preclinical strategies, including the improvement of sophisticated mouse models and co-clinical study designs, are being used to augment the predictive value of animal-based translational cancer research. Here, we review the development of successful preclinical antineoplastic agents, their associated limitations, and alternative methods to predict clinical outcomes.

Authors

Grit S. Herter-Sprie, Andrew L. Kung, Kwok-Kin Wong

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Figure 1

Comparative analysis of GEM and PDX models to mimic human malignancies.

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Comparative analysis of GEM and PDX models to mimic human malignancies.
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Green indicates similar features, red indicates divergent attributes.

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