Intrarenal control mechanisms play an important role in the maintenance of body fluid and electrolyte balance and pH homeostasis. Recent discoveries of new ion transport and regulatory pathways in the distal nephron and collecting duct system have helped to better our understanding of these critical kidney functions and identified new potential therapeutic targets and approaches. In this issue of the
János Peti-Peterdi
Illustration of the renal expression and functions of mitochondrial TCA cycle intermediates in the regulation of body fluid and acid-base balance.