Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the management of this condition. We have tested the hypothesis that BPs suppress apoptosis in these cell types. Etidronate, alendronate, pamidronate, olpadronate, or amino-olpadronate (IG9402, a bisphosphonate that lacks antiresorptive activity) at 10–9 to 10–6 M prevented apoptosis of murine osteocytic MLO-Y4 cells, whether it was induced by etoposide, TNF-α, or the synthetic glucocorticoid dexamethasone. BPs also inhibited apoptosis of primary murine osteoblastic cells isolated from calvaria. Similar antiapoptotic effects on MLO-Y4 and osteoblastic cells were seen with nanomolar concentrations of the peptide hormone calcitonin. The antiapoptotic effect of BPs and calcitonin was associated with a rapid increase in the phosphorylated fraction of extracellular signal regulated kinases (ERKs) and was blocked by specific inhibitors of ERK activation. Consistent with these in vitro results, alendronate abolished the increased prevalence of apoptosis in vertebral cancellous bone osteocytes and osteoblasts that follows prednisolone administration to mice. These results suggest that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due, in part, to their ability to prevent osteocyte and osteoblast apoptosis.
Lilian I. Plotkin, Robert S. Weinstein, A. Michael Parfitt, Paula K. Roberson, Stavros C. Manolagas, Teresita Bellido
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Advancements in Bone Replacement Techniques–Potential Uses After Maxillary and Mandibular Resections Due to Medication-Related Osteonecrosis of the Jaw (MRONJ)
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Cells | 2025 |
Capsaicin counteracts dexamethasone-induced osteoporosis and metabolic disturbances in rats: role of AMPK/SIRT1/β-catenin/RUNX2 pathway.
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Teresita Bellido |
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Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis
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A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow‐Fed Young Adult Mice
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Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma
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Journal of biomedical materials research. Part A | 2020 |
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Advanced Healthcare Materials | 2020 |
In vitro and in vivo studies using non-traditional bisphosphonates
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Vertebral Compression Fractures in Osteoporotic and Pathologic Bone: A Clinical Guide to Diagnosis and Management
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2020 | |
Treatment of patients with diabetes mellitus and postmenopausal osteoporosis — difficulties of choice
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Rossiiskii vestnik akushera-ginekologa | 2020 |
Therapeutic and functional approach for the treatment of patients with bone marrow edema in Rehabilitation Medicine
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2020 | |
Phenomenon of osteocyte lacunar mineralization: indicator of former osteocyte death and a novel marker of impaired bone quality?
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Endocrine Connections | 2020 |
Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling
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Endocrinology | 2019 |
Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover
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The FEBS journal | 2019 |
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Physiological reviews | 2019 |
Current Treatments and New Developments in the Management of Glucocorticoid-induced Osteoporosis
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Ibandronate Treatment Before and After Implant Insertion Impairs Osseointegration in Aged Rats with Ovariectomy Induced Osteoporosis: IBANDRONATE TREATMENT IMPAIRS OSSEOINTEGRATION IN OVARIECTOMIZED RATS
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JBMR Plus | 2019 |
High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro
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Bone | 2019 |
Immobilization of BMP‐2, BMP‐7 and alendronic acid on titanium surfaces: Adhesion, proliferation and differentiation of bone marrow‐derived stem cells
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Journal of biomedical materials research. Part A | 2019 |
Mechanisms of palmitate-induced lipotoxicity in osteocytes
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Bone | 2019 |
Alendronate inhibits osteocyte apoptosis and inflammation via IL ‐6, inhibiting bone resorption in periapical lesions of ovariectomized rats
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International Endodontic Journal | 2019 |
The effect of risedronate on orthodontic tooth movement in ovariectomized rats
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Archives of Oral Biology | 2019 |
Osteosarcopenia: Bone, Muscle and Fat Interactions
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2019 | |
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1
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Frontiers in immunology | 2018 |
Glucocorticoid Excess in Bone and Muscle
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Clinical Reviews in Bone and Mineral Metabolism | 2018 |
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British Journal of Clinical Pharmacology | 2018 |
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Maxillofacial Plastic and Reconstructive Surgery | 2018 |
Positive Effects of Bisphosphonates on Osteogenic Differentiation in Patient-Derived Mesenchymal Stem Cells for the Treatment of Osteoporosis
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Tissue Engineering and Regenerative Medicine | 2018 |
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Osteoporosis International | 2018 |
Cytoprotective effect of flavonoid-induced autophagy on bisphosphonate mediated cell death in osteoblast
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Journal of Cellular Biochemistry | 2018 |
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Clinical epidemiology | 2018 |
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Stem Cell Research & Therapy | 2018 |
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2018 | |
Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy
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Plastic and Thoracic Surgery, Orthopedics and Ophthalmology
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2018 | |
Mechanical, hormonal and metabolic influences on blood vessels, blood flow and bone
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Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism
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Endocrinology | 2017 |
Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone Receptor on Bone Acquisition: PRCKO IN MSCS POTENTIATES BONE ACCRUAL
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Progress in molecular biology and translational science | 2017 |
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
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Scientific Reports | 2017 |
Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling
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Bone | 2017 |
Treatment Advances in Chronic Non-Bacterial Osteomyelitis and Other Autoinflammatory Bone Conditions
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Current Treatment Options in Rheumatology | 2017 |
What Animal Models Have Taught Us About the Safety and Efficacy of Bisphosphonates in Chronic Kidney Disease
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Current Osteoporosis Reports | 2017 |
Effects of teriparatide versus alendronate for treatment of postmenopausal osteoporosis: A meta-analysis of randomized controlled trials
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Medicine | 2017 |
Enhanced Osteogenic Differentiation in Zoledronate-Treated Osteoporotic Patients
LD Carbonare, M Mottes, G Malerba, A Mori, M Zaninotto, M Plebani, A Dellantonio, M Valenti |
International journal of molecular sciences | 2017 |
Impairment of cold injury-induced muscle regeneration in mice receiving a combination of bone fracture and alendronate treatment
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PloS one | 2017 |
Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells
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Journal of Molecular Endocrinology | 2017 |
High glucose alters the secretome of mechanically stimulated osteocyte-like cells affecting osteoclast precursor recruitment and differentiation
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Journal of Cellular Physiology | 2017 |
Cytoprotective effects of melatonin on zoledronic acid-treated human osteoblasts
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Journal of Cranio-Maxillofacial Surgery | 2017 |
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway
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Theranostics | 2017 |
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Journal of Materials Chemistry B | 2017 |
Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats
T Ye, P Cao, J Qi, Q Zhou, DS Rao, S Qiu, V Geoffroy |
PloS one | 2017 |
Studies regarding the induced thermal degradation, kinetic analysis and possible interactions with various excipients of an osseointegration agent: zoledronic acid
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Journal of Thermal Analysis and Calorimetry | 2017 |
Osteonecrosis
AR Zorzi, JB de Miranda |
Osteonecrosis | 2017 |
Osteoblast as a target of anti-osteoporotic treatment
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Postgraduate Medicine | 2017 |
A supplement-free osteoclast-osteoblast co-culture for pre-clinical application
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Journal of Cellular Physiology | 2017 |
Bone Toxicology
SY Smith, A Varela, R Samadfam |
Bone Toxicology | 2017 |
Response of trabecular bone, thyroid C and follicular cells to synthetic salmon calcitonin in middle-aged orchidectomized male rats
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Journal of Anatomy | 2017 |
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Endocrinology | 2017 |
Protection from Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
AY Sato, M Cregor, J Delgado-Calle, KW Condon, MR Allen, M Peacock, LI Plotkin, T Bellido |
Journal of Bone and Mineral Research | 2016 |
Osteocytic signalling pathways as therapeutic targets for bone fragility
LI Plotkin, T Bellido |
Nature Reviews Endocrinology | 2016 |
Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement
JA Siddiqui, NC Partridge |
Physiology (Bethesda, Md.) | 2016 |
Cancer Treatment and Research
H Eda, L Santo, GD Roodman, N Raje |
Cancer treatment and research | 2016 |
Zoledronic acid increases the circulating soluble RANKL level in mice, with a further increase in lymphocyte-derived soluble RANKL in zoledronic acid- and glucocorticoid-treated mice stimulated with bacterial lipopolysaccharide
T Abe, T Sato, S Kokabu, N Hori, Y Shimamura, T Sato, T Yoda |
Cytokine | 2016 |
Zoledronate for Osteogenesis imperfecta: evaluation of safety profile in children
C Kumar, I Panigrahi, AS Aradhya, BL Meena, N Khandelwal |
Journal of Pediatric Endocrinology and Metabolism | 2016 |
Blood flow controls bone vascular function and osteogenesis
SK Ramasamy, AP Kusumbe, M Schiller, D Zeuschner, MG Bixel, C Milia, J Gamrekelashvili, A Limbourg, A Medvinsky, MM Santoro, FP Limbourg, RH Adams |
Nature Communications | 2016 |
Osteonecrosis of the Jaw—a Bone Site-Specific Effect of Bisphosphonates
JA Vermeer, GA Renders, V Everts |
Current Osteoporosis Reports | 2016 |
Pamidronate Down-regulates Tumor Necrosis Factor-alpha Induced Matrix Metalloproteinases Expression in Human Intervertebral Disc Cells
YM Kang, SH Hong, JH Yang, JC Oh, JO Park, BH Lee, SY Lee, HS Kim, HM Lee, SH Moon |
Journal of Bone Metabolism | 2016 |
Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
T Komori |
International journal of molecular sciences | 2016 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Stiffness and strength of bone in osteoporotic patients treated with varying durations of oral bisphosphonates
J Ward, C Wood, K Rouch, D Pienkowski, HH Malluche |
Osteoporosis International | 2016 |
Osteoporosis in Older Persons
JA Cauley |
Osteoporosis in Older Persons | 2016 |
Principles of Osteoimmunology
DH White, R Kocijan |
Principles of Osteoimmunology | 2016 |
Effects of drug discontinuation after short-term daily alendronate administration on osteoblasts and osteocytes in mice
K Tsuboi, T Hasegawa, T Yamamoto, M Sasaki, H Hongo, PH de Freitas, T Shimizu, M Takahata, K Oda, T Michigami, M Li, Y Kitagawa, N Amizuka |
Histochemistry and Cell Biology | 2016 |
The effect of vitamin D and bisphosphonate on fracture healing: An experimental study
NH Aydoğan, İ Özel, S İltar, T Kara, A Özmeriç, KB Alemdaroğlu |
Journal of Clinical Orthopaedics and Trauma | 2016 |
OSU53 Rescues Human OB-6 Osteoblastic Cells from Dexamethasone through Activating AMPK Signaling
D Xu, W Zhao, X Zhu, J Fan, S Cui, Y Sun, X Chen, W Liu, Z Cui, C Cao |
PloS one | 2016 |
Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength: BCLXL OVEREXPRESSION INCREASES BONE WITH STRENGTH
T Moriishi, R Fukuyama, T Miyazaki, T Furuichi, M Ito, T Komori |
Journal of Bone and Mineral Research | 2016 |
Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner
G Pellegrini, C Morales, T Wallace, L Plotkin, T Bellido |
Nutrients | 2016 |
Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase
JB Rodriguez, BN Falcone, SH Szajnman |
Expert Opinion on Drug Discovery | 2016 |
Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw
JW Kim, ME Landayan, JY Lee, JC Tatad, SJ Kim, MR Kim, IH Cha |
Clinical Oral Investigations | 2016 |
Revisiting bone targeting potential of novel hydroxyapatite based surface modified PLGA nanoparticles of risedronate: Pharmacokinetic and biochemical assessment
P Rawat, I Ahmad, SC Thomas, S Pandey, D Vohora, S Gupta, FJ Ahmad, S Talegaonkar |
International Journal of Pharmaceutics | 2016 |
The effect of alendronate soaking and ultraviolet treatment on bone-implant interface
HS Kim, JI Lee, SS Yang, BS Kim, BC Kim, J Lee |
Clinical Oral Implants Research | 2016 |
The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth
P Duan, LF Bonewald |
The International Journal of Biochemistry & Cell Biology | 2016 |
Akt drives buffalo casein derived novel peptide mediated osteoblast differentiation
S Reddi, N Kumar, R Vij, SB Mada, S Kapila, R Kapila |
The Journal of Nutritional Biochemistry | 2016 |
Defining the role of bisphosphonates for osteonecrosis of the knee: a systematic review
RW Jordan, AD Jones, AJ Pearse |
Current Orthopaedic Practice | 2016 |
Structural Biology of Calcitonin: From Aqueous Therapeutic Properties to Amyloid Aggregation
K Kamgar-Parsi, J Tolchard, B Habenstein, A Loquet, A Naito, A Ramamoorthy |
Israel Journal of Chemistry | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Cadmium modulates hematopoietic stem and progenitor cells and skews toward myelopoiesis in mice
Y Zhang, X Yu, S Sun, Q Li, Y Xie, Q Li, Y Zhao, J Pei, W Zhang, P Xue, Z Zhou, Y Zhang |
Toxicology and Applied Pharmacology | 2016 |
Alendronate Can Improve Bone Alterations in Experimental Diabetes by Preventing Antiosteogenic, Antichondrogenic, and Proadipocytic Effects of AGEs on Bone Marrow Progenitor Cells
SR Chuguransky, AM Cortizo, AD McCarthy |
BioMed Research International | 2016 |
Effect of buffalo casein-derived novel bioactive peptides on osteoblast differentiation
S Reddi, VP Shanmugam, KS Tanedjeu, S Kapila, R Kapila |
European Journal of Nutrition | 2016 |
microRNA-25 targets PKCζ and protects osteoblastic cells from dexamethasone via activating AMPK signaling
J Fan, W Liu, X Zhu, H Yi, S Cui, J Zhao, Z Cui |
Oncotarget | 2016 |
miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone
J Fan, J Ruan, W Liu, L Zhu, X Zhu, H Yi, S Cui, J Zhao, Z Cui |
Oncotarget | 2016 |
Hypoxia mediates osteocyte ORP150 expression and cell death in vitro
M Montesi, K Jähn, L Bonewald, S Stea, B Bordini, A Beraudi |
Molecular medicine reports | 2016 |
Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy
K Hartmann, M Koenen, S Schauer, S Wittig-Blaich, M Ahmad, U Baschant, JP Tuckermann |
Physiological reviews | 2016 |
PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading: PTHrP-DERIVED PEPTIDES RESTORE BONE MASS IN DIABETIC MICE
M Maycas, KA McAndrews, AY Sato, GG Pellegrini, DM Brown, MR Allen, LI Plotkin, AR Gortazar, P Esbrit, T Bellido |
Journal of Bone and Mineral Research | 2016 |
Pediatric Lower Limb Deformities
S Sabharwal |
2016 | |
Calcitonin, the forgotten hormone: does it deserve to be forgotten?
AJ Felsenfeld, BS Levine |
Clinical Kidney Journal | 2015 |
Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities
G Shay, L Hazlehurst, CC Lynch |
Journal of Molecular Medicine | 2015 |
American Society of Biomechanics Journal of Biomechanics Award 2013: Cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures
JR Geissler, D Bajaj, JC Fritton |
Journal of Biomechanics | 2015 |
Multi-level characterization of human femoral cortices and their underlying osteocyte network reveal trends in quality of young, aged, osteoporotic and antiresorptive-treated bone
P Milovanovic, EA Zimmermann, C Riedel, A Scheidt, L Herzog, M Krause, D Djonic, M Djuric, K Püschel, M Amling, RO Ritchie, B Busse |
Biomaterials | 2015 |
Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice
AY Sato, X Tu, KA McAndrews, LI Plotkin, T Bellido |
Bone | 2015 |
Dexamethasone-induced apoptosis of osteocytic and osteoblastic cells is mediated by TAK1 activation
H Ding, T Wang, D Xu, B Cha, J Liu, Y Li |
Biochemical and Biophysical Research Communications | 2015 |
Bisphosphonates and their influence on fracture healing: a systematic review
H Molvik, W Khan |
Osteoporosis International | 2015 |
Bisphosphonate treatment of type I diabetic mice prevents early bone loss but accentuates suppression of bone formation: ALENDRONATE RESCUES DIABETIC BONE LOSS
LM Coe, SA Tekalur, Y Shu, MJ Baumann, LR McCabe |
Journal of Cellular Physiology | 2015 |
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more
LI Plotkin, JP Stains |
Cellular and Molecular Life Sciences | 2015 |
Effects of Alendronate Sodium Content on the Interface Strengths of Composite Acrylic Bone Cement
DY Song, XZ Mao, M Ding, JD Ni |
International Journal of Endocrinology | 2015 |
99mTC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice
ZA Zhong, A Peck, S Li, J VanOss, J Snider, CJ Droscha, TA Chang, BO Williams |
Bone Research | 2015 |
Coupling Hydroxyapatite Nanocrystals with Lactoferrin as a Promising Strategy to Fine Regulate Bone Homeostasis
M Montesi, S Panseri, M Iafisco, A Adamiano, A Tampieri, D Heymann |
PloS one | 2015 |
Bone Cancer
PG Fournier, P Juárez, TA Guise |
Bone Cancer | 2015 |
Inhibition of Osteocyte Apoptosis Prevents the Increase in Osteocytic Receptor Activator of Nuclear Factor κB Ligand (RANKL) but Does Not Stop Bone Resorption or the Loss of Bone Induced by Unloading
LI Plotkin, AR Gortazar, HM Davis, KW Condon, H Gabilondo, M Maycas, MR Allen, T Bellido |
The Journal of biological chemistry | 2015 |
The Effect of Local Delivery Doxycycline and Alendronate on Bone Repair
PH Limirio, FS Rocha, JD Batista, JC Guimarães-Henriques, GB de Melo, P Dechichi |
AAPS PharmSciTech | 2015 |
Concentration-dependent effects of alendronate and pamidronate functionalized gold nanoparticles on osteoclast and osteoblast viability: CONNERS, BHETHANABOTLA, AND GUPTA
CM Conners, VR Bhethanabotla, VK Gupta |
Journal of Biomedical Materials Research Part B Applied Biomaterials | 2015 |
Alendronate–calcium phosphate hybrid films promoted the osteoblast differentiation and inhibited osteoclastogenic activity
WK Yang, EJ Chang, WK Lee |
Journal of Industrial and Engineering Chemistry | 2015 |
Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage
C Liu, X Zhang, M Wu, L You |
Journal of Biomechanics | 2015 |
Medication-Related Osteonecrosis of the Jaw
MR Allen |
Oral and Maxillofacial Surgery Clinics of North America | 2015 |
Ameliorating effect of combination of simvastatin and residronate on glucocorticoid induced osteoporosis model in rats
S Ahmed, ED Alaa, AM Ahmed |
AFR J PHARM PHARMACO | 2015 |
Blistering Diseases
DF Murrell |
2015 | |
Connexin 43 hemichannels and intracellular signaling in bone cells
LI Plotkin |
Frontiers in physiology | 2014 |
Apoptotic Osteocytes and the Control of Targeted Bone Resorption
LI Plotkin |
Current Osteoporosis Reports | 2014 |
Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis
R Sanguineti, A Puddu, F Mach, F Montecucco, GL Viviani |
Mediators of Inflammation | 2014 |
Glucocorticoids and bone: local effects and systemic implications
H Henneicke, SJ Gasparini, TC Brennan-Speranza, H Zhou, MJ Seibel |
Trends in Endocrinology & Metabolism | 2014 |
Modifying the osteoblastic niche with zoledronic acid in vivo—Potential implications for breast cancer bone metastasis
MT Haider, I Holen, TN Dear, K Hunter, HK Brown |
Bone | 2014 |
Pharmacological management of osteogenesis.
Nardone V, D'Asta F, Brandi ML |
2014 | |
Effects of clodronate and alendronate on osteoclast and osteoblast co-cultures on silk–hydroxyapatite films
RS Hayden, M Vollrath, DL Kaplan |
Acta Biomaterialia | 2014 |
Bisphosphonates and bone quality
M Pazianas, S der Geest, P Miller |
BoneKEy Reports | 2014 |
Osteoblastic protein tyrosine phosphatases inhibition and connexin 43 phosphorylation by alendronate
V Lezcano, T Bellido, LI Plotkin, R Boland, S Morelli |
Experimental Cell Research | 2014 |
Osteoblastic cell secretome: A novel role for progranulin during risedronate treatment
M Romanello, E Piatkowska, G Antoniali, L Cesaratto, C Vascotto, RV Iozzo, D Delneri, FL Brancia |
Bone | 2014 |
Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation
T Moriishi, Y Kawai, H Komori, S Rokutanda, Y Eguchi, Y Tsujimoto, I Asahina, T Komori |
PloS one | 2014 |
Controlled delivery of zoledronate improved bone formation locally in vivo
W Gou, X Wang, J Peng, Q Lu, Y Wang, A Wang, Q Guo, X Gao, W Xu, S Lu |
PloS one | 2014 |
Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts
J Hou, E Chen, S Wei, F Lin, Q Lin, X Lan, Y Xue, M Wu |
Acta Pharmacologica Sinica | 2014 |
Porous NiTi shape memory alloys produced by SHS: microstructure and biocompatibility in comparison with Ti2Ni and TiNi3
P Bassani, S Panseri, A Ruffini, M Montesi, M Ghetti, C Zanotti, A Tampieri, A Tuissi |
Journal of Materials Science: Materials in Medicine | 2014 |
The role of muscle loading on bone (Re)modeling at the developing enthesis
AM Tatara, JH Lipner, R Das, HM Kim, N Patel, E Ntouvali, MJ Silva, S Thomopoulos |
PloS one | 2014 |
Bisphosphonates: Pharmacology and Clinical Approach to Their Use in Equine Osteoarticular Diseases
SA Soto, AC Barbará |
Journal of Equine Veterinary Science | 2014 |
Osteocytes and Osteoclasts, a Relationship Under Strain
AD Bakker, V Everts |
Clinical Reviews in Bone and Mineral Metabolism | 2014 |
Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo
U Kettenberger, J Ston, E Thein, P Procter, DP Pioletti |
Biomaterials | 2014 |
Treatment of osteoporosis: current state of the art
I Hamrick, S Schrager, AM Nye |
Wiener Medizinische Wochenschrift | 2014 |
Pharmacological management of osteogenesis
V Nardone, F D'Asta, ML Brandi |
Clinics (São Paulo, Brazil) | 2014 |
High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation
R Pacheco-Costa, I Hassan, RD Reginato, HM Davis, A Bruzzaniti, MR Allen, LI Plotkin |
The Journal of biological chemistry | 2014 |
Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats
HS Alghamdi, R Bosco, SK Both, M Iafisco, SC Leeuwenburgh, JA Jansen, JJ van Beucken |
Biomaterials | 2014 |
Local application of zoledronate enhances miniscrew implant stability in dogs
C Cuairán, PM Campbell, E Kontogiorgos, RW Taylor, AC Melo, PH Buschang |
American Journal of Orthodontics and Dentofacial Orthopedics | 2014 |
The BRC Canopy
K Wesseling-Perry |
The American Journal of Pathology | 2014 |
Lethal cervical abscess following bisphosphonate related osteonecrosis of the jaw
C Kaehling, P Streckbein, D Schmermund, M Henrich, D Burchert, S Gattenloehner, HP Howaldt, JF Wilbrand |
Journal of Cranio-Maxillofacial Surgery | 2014 |
Parathyroid Hormone Receptor Signaling Induces Bone Resorption in the Adult Skeleton by Directly Regulating the RANKL Gene in Osteocytes
AN Ben-awadh, J Delgado-Calle, X Tu, K Kuhlenschmidt, MR Allen, LI Plotkin, T Bellido |
Endocrinology | 2014 |
El hueso en las enfermedades endocrinas y nutricionales
EJ Gimeno, MC Berdonces |
El hueso en las enfermedades endocrinas y nutricionales | 2014 |
CCL7 Is a Protective Factor Secreted by Mechanically Loaded Osteocytes
Y Kitase, S Lee, J Gluhak-Heinrich, ML Johnson, SE Harris, LF Bonewald |
Journal of dental research | 2014 |
Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors
TW Tai, FC Su, CY Chen, IM Jou, CF Lin |
Bone | 2014 |
Comment on Osteocytes: Masters Orchestrators of Bone
LI Plotkin, T Bellido |
Calcified Tissue International | 2014 |
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
Alendronate as an Effective Treatment for Bone Loss and Vascular Calcification in Kidney Transplant Recipients
M Okamoto, S Yamanaka, W Yoshimoto, T Shigematsu |
Journal of Transplantation | 2014 |
Controlled Delivery of Zoledronate Improved Bone Formation Locally In Vivo
W Gou, X Wang, J Peng, Q Lu, Y Wang, A Wang, Q Guo, X Gao, W Xu, S Lu, L Malaval |
PloS one | 2014 |
The Role of Muscle Loading on Bone (Re)modeling at the Developing Enthesis
AM Tatara, JH Lipner, R Das, HM Kim, N Patel, E Ntouvali, MJ Silva, S Thomopoulos, D Heymann |
PloS one | 2014 |
Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation
T Moriishi, Y Kawai, H Komori, S Rokutanda, Y Eguchi, Y Tsujimoto, I Asahina, T Komori, IV Lebedeva |
PloS one | 2014 |
Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load
Shane A Lloyd, Alayna E Loiselle, Yue Zhang, Henry J Donahue |
Journal of Bone and Mineral Research | 2014 |
Effects of Osteocyte Apoptosis on Bone Cell Proliferation and Recruitment
, SH Ko |
2014 | |
Shifting Paradigms on the Role of Connexin43 in the Skeletal Response to Mechanical Load
Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ |
Journal of Bone and Mineral Research | 2014 |
FoxOs attenuate bone formation by suppressing Wnt signaling
Srividhya Iyer, Elena Ambrogini, Shoshana M. Bartell, Li Han, Paula Roberson, Rafael de Cabo, Robert L. Jilka, Robert Weinstein, Charles O'Brien, Stavros Manolagas, Maria Almeida |
Journal of Clinical Investigation | 2013 |
The osteocyte: an endocrine cell ... and more
Sarah L Dallas, Matthew Prideaux, Lynda F Bonewald |
2013 | |
Non-Nuclear–Initiated Actions of the Estrogen Receptor Protect Cortical Bone Mass
SM Bartell, L Han, H Kim, SH Kim, JA Katzenellenbogen, BS Katzenellenbogen, KL Chambliss, PW Shaul, PK Roberson, RS Weinstein, RL Jilka, M Almeida, SC Manolagas |
Molecular Endocrinology | 2013 |
Review of New Guidelines for the Management of Glucocorticoid Induced Osteoporosis
SR Venuturupalli, W Sacks |
Current Osteoporosis Reports | 2013 |
Osteocyte-Driven Bone Remodeling
T Bellido |
Calcified Tissue International | 2013 |
Feeding blueberry diets to young rats dose-dependently inhibits bone resorption through suppression of RANKL in stromal cells
J Zhang, OP Lazarenko, J Kang, ML Blackburn, MJ Ronis, TM Badger, JR Chen |
PloS one | 2013 |
Glucocorticoids and Osteocyte Autophagy
W Yao, W Dai, JX Jiang, NE Lane |
Bone | 2013 |
Beyond gap junctions: Connexin43 and bone cell signaling
LI Plotkin, T Bellido |
Bone | 2013 |
Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
YJ Lee, JK Jeong, JW Seol, M Xue, C Jackson, SY Park |
Experimental & molecular medicine | 2013 |
An In Vitro Assessment of Fibroblast and Osteoblast Response to Alendronate-Modified Titanium and the Potential for Decreasing Fibrous Encapsulation
X Hu, KG Neoh, Z Shi, ET Kang, W Wang |
Tissue Engineering Part A | 2013 |
Documenting the Use of Calcium Supplements with Oral Bisphosphonates
AM Nye, I Hamrick, A Rauch, MW Pound, PS Shelton |
The Consultant Pharmacist | 2013 |
Effects of minodronate on cortical bone response to mechanical loading in rats
K Nagira, H Hagino, Y Kameyama, R Teshima |
Bone | 2013 |
Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway
Z Wang, J Guo |
Cell Biochemistry and Biophysics | 2013 |
Risedronate increases osteoblastic differentiation and function through connexin43
HM Jeong, YH Jin, YH Choi, JO Chung, DH Cho, MY Chung, R Civitelli, DJ Chung, KY Lee |
Biochemical and Biophysical Research Communications | 2013 |
Icariin Protects Against Glucocorticoid-Induced Osteoporosis In Vitro and Prevents Glucocorticoid-Induced Osteocyte Apoptosis In Vivo
R Feng, L Feng, Z Yuan, D Wang, F Wang, B Tan, S Han, T Li, D Li, Y Han |
Cell Biochemistry and Biophysics | 2013 |
Calcitonin: Physiology or fantasy?
RA Davey, DM Findlay |
Journal of Bone and Mineral Research | 2013 |
Healing of the bone with anti-fracture drugs
ML Brandi |
Expert Opinion on Pharmacotherapy | 2013 |
Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives
MJ Seibel, MS Cooper, H Zhou |
The Lancet Diabetes & Endocrinology | 2013 |
Molecular determinants of glucocorticoid actions in inflammatory joint diseases
U Baschant, S Culemann, J Tuckermann |
Molecular and Cellular Endocrinology | 2013 |
Osteoanabolic effect of alendronate and zoledronate on bone marrow stromal cells (BMSCs) isolated from aged female osteoporotic patients and its implications for their mode of action in the treatment of age-related bone loss
RA Lindtner, AN Tiaden, K Genelin, HL Ebner, C Manzl, M Klawitter, I Sitte, B Rechenberg, M Blauth, PJ Richards |
Osteoporosis International | 2013 |
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
MD Ruppe, SM de Beur |
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism | 2013 |
Kieferosteonekrose unter antiosteoklastischer Therapie
IA Adamietz, M Kunkel |
Der Onkologe | 2013 |
The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis
A Al-Kashi, T Montero-Melendez, N Moradi-Bidhendi, JP Gilligan, N Mehta, M Perretti |
PloS one | 2013 |
Preosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblasts
E Torreggiani, BG Matthews, S Pejda, I Matic, MC Horowitz, D Grcevic, I Kalajzic |
PloS one | 2013 |
Can Zoledronic Acid be Beneficial for Promoting Tumor Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
A Charehbili, D Fontein, J Kroep, GJ Liefers, J Nortier, C Velde |
Journal of Clinical Medicine | 2013 |
Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice
C Flores, I Moscatelli, CS Thudium, NS Gudmann, JS Thomsen, A Brüel, MA Karsdal, K Henriksen, J Richter |
Haematologica | 2013 |
Efficacy of pamidronate in children with low bone mineral density during and after chemotherapy for acute lymphoblastic leukemia and non-Hodgkin lymphoma
JM Lee, JE Kim, SH Bae, JO Hah |
Blood Research | 2013 |
Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and β-catenin survival pathways in osteocyte mechanotransduction
AR Gortazar, M Martin-Millan, B Bravo, LI Plotkin, T Bellido |
The Journal of biological chemistry | 2013 |
Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice
N Bivi, R Pacheco-Costa, LR Brun, TR Murphy, NR Farlow, AG Robling, T Bellido, LI Plotkin |
Journal of Orthopaedic Research | 2013 |
Differential impact of the Bisphosphonate Alendronate on undifferentiated and terminally differentiated human myogenic cells: Impact of Alendronate on human myogenic cell
K Shiomi, Y Nagata, T Kiyono, A Harada, N Hashimoto |
Journal of Pharmacy and Pharmacology | 2013 |
Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells
R Thaler, S Spitzer, H Karlic, C Berger, K Klaushofer, F Varga |
Biochemical Pharmacology | 2013 |
Sequential treatment with monofluorophosphate and zoledronic acid in osteoporotic rats
ML Brance, LR Brun, VE di Loreto, M Lupo, A Rigalli |
Climacteric | 2013 |
Bisphosphonates beyond their anti-osteoclastic properties
M Varenna |
Rheumatology | 2013 |
Painful prosthesis: approaching the patient with persistent pain following total hip and knee arthroplasty
P Piscitelli, G Iolascon, M Innocenti, R Civinini, A Rubinacci, M Muratore, M D'Arienzo, PT Leali, AM Carossino, ML Brandi |
Clinical Cases in Mineral and Bone Metabolism | 2013 |
Preosteocytes/Osteocytes Have the Potential to Dedifferentiate Becoming a Source of Osteoblasts
E Torreggiani, BG Matthews, S Pejda, I Matic, MC Horowitz, D Grcevic, I Kalajzic, S Gronthos |
PloS one | 2013 |
Crosstalk between Caveolin-1/Extracellular Signal-regulated Kinase (ERK) and β-Catenin Survival Pathways in Osteocyte Mechanotransduction*
AR Gortazar, M Martin-Millan, B Bravo, LI Plotkin, T Bellido |
The Journal of biological chemistry | 2013 |
The Osteocyte: An Endocrine Cell ... and More
Sarah L. Dallas, Matthew Prideaux, Lynda F. Bonewald |
2013 | |
The Osteocyte: An Endocrine Cell … and More
SL Dallas, M Prideaux, LF Bonewald |
Endocrine reviews | 2013 |
Bisphosphonates and Cancer: What Opportunities from Nanotechnology?
GD Rosa, G Misso, G Salzano, M Caraglia |
Journal of drug delivery | 2013 |
Feeding Blueberry Diets to Young Rats Dose-Dependently Inhibits Bone Resorption through Suppression of RANKL in Stromal Cells
J Zhang, OP Lazarenko, J Kang, ML Blackburn, MJ Ronis, TM Badger, JR Chen, XM Shi |
PloS one | 2013 |
The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class–Effect Synergy in Experimental Arthritis
A Al-Kashi, T Montero-Melendez, N Moradi-Bidhendi, JP Gilligan, N Mehta, M Perretti, J Wallace |
PloS one | 2013 |
Osteoanabolic effect of alendronate and zoledronate on bone marrow stromal cells (BMSCs) isolated from aged female osteoporotic patients and its implications for their mode of action in the treatment of age-related bone loss
RA Lindtner, AN Tiaden, K Genelin, HL Ebner, C Manzl, M Klawitter, I Sitte, B von Rechenberg, M Blauth, PJ Richards |
Osteoporosis International | 2013 |
The osteoblast progenitor ERα stimulates Wnt signaling and bone accrual
Maria Almeida, Srividhya Iyer, Marta Martin-Millan, Shoshana M. Bartell, Li Han, Elena Ambrogini, Melda Onal, Jinhu Xiong, Robert Weinstein, Robert L. Jilka, Charles A. O'Brien, Stavros Manolagas |
Journal of Clinical Investigation | 2012 |
RSK2 protects mice against TNF-induced bone loss
C Böhm, A Derer, R Axmann, U Hillienhoff, MM Zaiss, J Luther, C Zech, M Stock, C Scholtysek, K Engelke, A Hess, JP Tuckermann, G Schett, JP David |
Journal of cell science | 2012 |
Bisphosphonates: effects on osteoblast
N Maruotti, A Corrado, A Neve, FP Cantatore |
European Journal of Clinical Pharmacology | 2012 |
In vitro and in vivo approaches to study osteocyte biology
I Kalajzic, BG Matthews, E Torreggiani, MA Harris, PD Pajevic, SE Harris |
Bone | 2012 |
Glucocorticoid-induced osteoporosis and osteonecrosis
RS Weinstein |
Endocrinology and metabolism clinics of North America | 2012 |
Is interaction between age-dependent decline in mechanical stimulation and osteocyte–estrogen receptor levels the culprit for postmenopausal-impaired bone formation?
R Sapir-Koren, G Livshits |
Osteoporosis International | 2012 |
The multiple facets of glucocorticoid action in rheumatoid arthritis
U Baschant, NE Lane, J Tuckermann |
Nature Reviews Rheumatology | 2012 |
Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways
V Lezcano, T Bellido, LI Plotkin, R Boland, S Morelli |
Archives of Biochemistry and Biophysics | 2012 |
Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits
J Turek, FH Ebetino, MW Lundy, S Sun, BA Kashemirov, CE McKenna, MA Gallant, LI Plotkin, T Bellido, X Duan, JT Triffitt, RG Russell, DB Burr, MR Allen |
Calcified Tissue International | 2012 |
Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
N Bivi, KW Condon, MR Allen, N Farlow, G Passeri, LR Brun, Y Rhee, T Bellido, LI Plotkin |
Journal of Bone and Mineral Research | 2012 |
Evolution of bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma and Waldenstrom's macroglobulinemia: a retrospective multicentric study
A Andriani, MT Petrucci, T Caravita, M Montanaro, N Villivà, A Levi, A Siniscalchi, V Bongarzoni, F Pisani, MD Muro, U Coppetelli, G Avvisati, A Zullo, A Agrillo, D Gaglioti |
Blood Cancer Journal | 2012 |
Deletion of Cx43 from Osteocytes Results in Defective Bone Material Properties but Does Not Decrease Extrinsic Strength in Cortical Bone
N Bivi, MT Nelson, ME Faillace, J Li, LM Miller, LI Plotkin |
Calcified Tissue International | 2012 |
Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation
N Giuliani, M Ferretti, M Bolzoni, P Storti, M Lazzaretti, BD Palma, S Bonomini, E Martella, L Agnelli, A Neri, F Ceccarelli, C Palumbo |
Leukemia | 2012 |
The Epidemiology of Distal Radius Fractures
KW Nellans, E Kowalski, KC Chung |
Hand Clinics | 2012 |
Osteoconductive action of alendronate after implantation of beta tricalcium phosphate in rat adjuvant-induced arthritis
T Netsu, N Kondo, K Arai, A Ogose, N Endo |
Journal of Bone and Mineral Metabolism | 2012 |
The role of bone turnover markers in monitoring treatment in postmenopausal osteoporosis
P Szulc |
Clinical Biochemistry | 2012 |
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
AJ Roelofs, CA Stewart, S Sun, KM Błażewska, BA Kashemirov, CE McKenna, RG Russell, MJ Rogers, MW Lundy, FH Ebetino, FP Coxon |
Journal of Bone and Mineral Research | 2012 |
An aromatase polymorphism (g.132810C>T) predicts risk of bisphosphonate-related osteonecrosis of the jaw
FL Ferla, E Paolicchi, F Crea, S Cei, F Graziani, M Gabriele, R Danesi |
Biomarkers in Medicine | 2012 |
Pediatric Bone
M Bastepe, H Jüppner, RV Thakker |
Pediatric Bone | 2012 |
Comparison of Serum Dkk1 (Dickopff-1) and Bone Mineral Density in Patients on Bisphosphonate Treatment Vs no Treatment
AR Memon, JS Butler, MV O'Riordan, E Guerin, BD Dimitrov, JA Harty |
Journal of Clinical Densitometry | 2012 |
Effectiveness of pamidronate as treatment of symptomatic osteonecrosis occurring in children treated for acute lymphoblastic leukemia
C Leblicq, C Laverdière, JC Décarie, JF Delisle, MH Isler, A Moghrabi, G Chabot, N Alos |
Pediatric Blood & Cancer | 2012 |
Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading
SA Lloyd, GS Lewis, Y Zhang, EM Paul, HJ Donahue |
Journal of Bone and Mineral Research | 2012 |
Prevention of aortic valve stenosis: A realistic therapeutic target?
DT Ngo, AL Sverdlov, JD Horowitz |
Pharmacology & Therapeutics | 2012 |
No Reduction in Circulating Preosteoclasts 18 Months after Treatment with Zoledronate: Analysis from a Randomized Placebo Controlled Trial
N Dalbeth, B Pool, A Stewart, A Horne, ME House, J Cornish, IR Reid |
Calcified Tissue International | 2012 |
Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β
KF Duesterdieck-Zellmer, N Driscoll, JF Ott |
American Journal of Veterinary Research | 2012 |
Gap junction and hemichannel functions in osteocytes
AE Loiselle, JX Jiang, HJ Donahue |
Bone | 2012 |
There are many potential medical therapies for atraumatic osteonecrosis
J Fessel |
Rheumatology | 2012 |
Clinical role of bisphosphonate therapy
G Hampson, I Fogelman |
International journal of women's health | 2012 |
Skeletal muscle secreted factors prevent glucocorticoid-induced osteocyte apoptosis through activation of β-catenin
K Jähn, N Lara-Castillo, L Brotto, CL Mo, ML Johnson, M Brotto, LF Bonewald |
European cells & materials | 2012 |
SKELETAL MUSCLE SECRETED FACTORS PREVENT GLUCOCORTICOID-INDUCED OSTEOCYTE APOPTOSIS THROUGH ACTIVATION OF B-CATENIN
K Jähn, N Lara-Castillo, L Brotto, CL Mo, ML Johnson, M Brotto, LF Bonewald |
European cells & materials | 2012 |
Low-dose Risedronate Sodium Protects Bone Cells after Abrupt Oestrogen Withdrawal
G Wang, Z Zhu, C Lei, M Li, F Liu, Y Mao, Z Yu, M Liu, X Zhao, T Tang |
J INT MED RES | 2012 |
Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse
BR Macias, JM Swift, MI Nilsson, HA Hogan, SD Bouse, SA Bloomfield |
Journal of applied physiology | 2012 |
Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone
N Bivi, V Lezcano, M Romanello, T Bellido, LI Plotkin |
Journal of Cellular Biochemistry | 2011 |
Glucocorticoid-induced osteonecrosis
RS Weinstein |
Endocrine | 2011 |
Osteoprotegerin Prevents Glucocorticoid-Induced Osteocyte Apoptosis in Mice
RS Weinstein, CA O'Brien, M Almeida, H Zhao, PK Roberson, RL Jilka, SC Manolagas |
Endocrinology | 2011 |
Glucocorticoid dose determines osteocyte cell fate
J Jia, W Yao, M Guan, W Dai, M Shahnazari, R Kar, L Bonewald, JX Jiang, NE Lane |
The FASEB Journal | 2011 |
A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice
LI Plotkin, N Bivi, T Bellido |
Bone | 2011 |
Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability
T Bellido, LI Plotkin |
Bone | 2011 |
LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1
S Ye, TW Fowler, NJ Pavlos, PY Ng, K Liang, Y Feng, M Zheng, R Kurten, SC Manolagas, H Zhao |
PloS one | 2011 |
Bisphosphonates: The first 40years
RG Russell |
Bone | 2011 |
Denosumab and bisphosphonates: Different mechanisms of action and effects
R Baron, S Ferrari, RG Russell |
Bone | 2011 |
The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing
MR Allen |
Odontology | 2011 |
Effect of Bisphosphonates on the Progression of Degenerative Aortic Stenosis
AL Innasimuthu, WE Katz |
Echocardiography | 2011 |
Bisphosphonates, specific inhibitors of osteoclast function and a class of drugs for osteoporosis therapy
B Li, JF Chau, X Wang, WF Leong |
Journal of Cellular Biochemistry | 2011 |
Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: What we think we know and what we know that we don't know
MR Allen, DB Burr |
Bone | 2011 |
Glucocorticoid-Induced Bone Disease
RS Weinstein |
New England Journal of Medicine | 2011 |
Bone-bound bisphosphonate inhibits growth of adjacent non-bone cells
J Cornish, U Bava, KE Callon, J Bai, D Naot, IR Reid |
Bone | 2011 |
Bisphosphonates in phenytoin-induced bone disorder
S Khanna, KK Pillai, D Vohora |
Bone | 2011 |
Protein phosphatases: Possible bisphosphonate binding sites mediating stimulation of osteoblast proliferation
S Morelli, PS Bilbao, S Katz, V Lezcano, E Roldán, R Boland, G Santillan |
Archives of Biochemistry and Biophysics | 2011 |
Dose-dependent differential effects of risedronate on gene expression in osteoblasts
J Wang, PH Stern |
Biochemical Pharmacology | 2011 |
Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors
G Duque, C Vidal, D Rivas |
British Journal of Pharmacology | 2011 |
International Review of Cell and Molecular Biology
A Chavez, M Smith, D Mehta |
International Review of Cell and Molecular Biology Volume 290 | 2011 |
Physiology of the aging bone and mechanisms of action of bisphosphonates
LJ Dominguez, G Bella, M Belvedere, M Barbagallo |
Biogerontology | 2011 |
Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs
Q Zhou, ZN Zhao, JT Cheng, B Zhang, J Xu, F Huang, RN Zhao, YJ Chen |
Biochemical and Biophysical Research Communications | 2011 |
Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes
N Bivi, P Picotti, LN Müller, M Romanello, L Moro, F Quadrifoglio, G Tell |
Journal of Proteomics | 2011 |
Densitometric Threshold and Vertebral Fractures in Heart Transplant Patients
LD Carbonare, M Zanatta, V Braga, S Sella, MT Vilei, G Feltrin, A Gambino, I Pepe, M Rossini, S Adami, S Giannini |
Transplantation | 2011 |
Bisphosphonates in orthopedic applications
JM Wilkinson, DG Little |
Bone | 2011 |
Cancellous bone formation response to simulated resistance training during disuse is blunted by concurrent alendronate treatment
JM Swift, SN Swift, MI Nilsson, HA Hogan, SD Bouse, SA Bloomfield |
Journal of Bone and Mineral Research | 2011 |
Alendronate and raloxifene affect the osteoprotegerin/RANKL system in human osteoblast primary cultures from patients with osteoporosis and osteoarthritis
M Giner, MJ Rios, MJ Montoya, MA Vázquez, C Miranda, R Pérez-Cano |
European Journal of Pharmacology | 2011 |
Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation
K Yoshitani, A Kido, K Honoki, M Akahane, H Fujii, Y Tanaka |
Pathology - Research and Practice | 2011 |
Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw
J Compston |
Osteoporosis International | 2011 |
Up-regulation of inhibitors of DNA binding/differentiation gene during alendronate-induced osteoblast differentiation
AR Kang, YR Oh, HY Kim, MJ Park, BS Joo, WJ Choi, JY Lee, MH Jung, YI Ji, JS Choi |
Archives of Gynecology and Obstetrics | 2011 |
Diagnosis and management of extensive vascular malformations of the lower limb
P Redondo, L Aguado, A Martínez-Cuesta |
Journal of the American Academy of Dermatology | 2011 |
Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures
Y Wang, A Panasiuk, DW Grainger |
Molecular Pharmaceutics | 2011 |
The Role of Bisphosphonates in Multiple Myeloma: Mechanisms, Side Effects, and the Future
S Pozzi, N Raje |
The oncologist | 2011 |
Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis
T Moriishi, Z Maruyama, R Fukuyama, M Ito, T Miyazaki, H Kitaura, H Ohnishi, T Furuichi, Y Kawai, R Masuyama, H Komori, K Takada, H Kawaguchi, T Komori |
PloS one | 2011 |
Bisphosphonate stimulation of osteoblasts and osteoblastic metastasis as a mechanism of hypocalcaemia
JW Ho |
Medical Hypotheses | 2011 |
Pathogenesis of aortic stenosis: not just a matter of wear and tear
AL Sverdlov, DT Ngo, MJ Chapman, OA Ali, YY Chirkov, JD Horowitz |
American Journal of Cardiovascular Disease | 2011 |
CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN
LI Plotkin |
Actualizaciones en osteologia | 2011 |
Ostéoporose cortisonique
C Marcelli |
EMC - Appareil locomoteur | 2011 |
Effects of risedronate on cortical and trabecular bone of the mandible in glucocorticoid-treated growing rats
Y Fujita, K Watanabe, S Uchikanbori, K Maki |
American Journal of Orthodontics and Dentofacial Orthopedics | 2011 |
A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis
Roberto Sacco, Gianluca Sacco, Alessandro Acocella, Silvana Sale, Nicola Sacco, Edoardo Baldoni |
Journal of applied oral science : revista FOB | 2011 |
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
E Ambrogini, M Almeida, M Martin-Millan, JH Paik, RA Depinho, L Han, J Goellner, RS Weinstein, RL Jilka, CA O'Brien, SC Manolagas |
Cell Metabolism | 2010 |
Glucocorticoid-Induced Autophagy in Osteocytes
X Xia, R Kar, J Gluhak-Heinrich, W Yao, NE Lane, LF Bonewald, SK Biswas, WK Lo, JX Jiang |
Journal of Bone and Mineral Research | 2010 |
The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone
M Martin-Millan, M Almeida, E Ambrogini, L Han, H Zhao, RS Weinstein, RL Jilka, CA O'Brien, SC Manolagas |
Molecular Endocrinology | 2010 |
Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice
RS Weinstein, RL Jilka, M Almeida, PK Roberson, SC Manolagas |
Endocrinology | 2010 |
Osteocyte apoptosis and control of bone resorption following ovariectomy in mice
KB Emerton, B Hu, AA Woo, A Sinofsky, C Hernandez, RJ Majeska, KJ Jepsen, MB Schaffler |
Bone | 2010 |
Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shc Signaling Cascade: Counter Regulation by Estrogens or Androgens
M Almeida, L Han, E Ambrogini, SM Bartell, SC Manolagas |
Molecular Endocrinology | 2010 |
Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
AJ Roelofs, FP Coxon, FH Ebetino, MW Lundy, ZJ Henneman, GH Nancollas, S Sun, KM Blazewska, JL Bala, BA Kashemirov, AB Khalid, CE McKenna, MJ Rogers |
Journal of Bone and Mineral Research | 2010 |
Osteocyte: the unrecognized side of bone tissue
GY Rochefort, S Pallu, CL Benhamou |
Osteoporosis International | 2010 |
The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation
MT Valenti, S Giannini, L Donatelli, M Zanatta, F Bertoldo, S Sella, MT Vilei, E Ossi, G Realdi, VL Cascio, LD Carbonare |
Arthritis Research & Therapy | 2010 |
RANKL Inhibition Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta
R Bargman, A Huang, AL Boskey, C Raggio, N Pleshko |
Connective Tissue Research | 2010 |
Near-infrared fluorescent probe traces bisphosphonate delivery and retention in vivo
KM Kozloff, LI Volakis, JC Marini, MS Caird |
Journal of Bone and Mineral Research | 2010 |
Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-α in C2C12 cells
Y Matsumoto, F Otsuka, M Takano, T Mukai, R Yamanaka, M Takeda, T Miyoshi, K Inagaki, K Sada, H Makino |
Molecular and Cellular Endocrinology | 2010 |
Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes
JH Gooi, S Pompolo, MA Karsdal, NH Kulkarni, I Kalajzic, SH McAhren, B Han, JE Onyia, PW Ho, MT Gillespie, NC Walsh, LY Chia, JM Quinn, TJ Martin, NA Sims |
Bone | 2010 |
Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management
LD Carbonare, M Zanatta, A Gasparetto, MT Valenti |
Drug, healthcare and patient safety | 2010 |
Inhibition of the progesterone nuclear receptor during the bone linear growth phase increases peak bone mass in female mice
W Yao, W Dai, M Shahnazari, A Pham, Z Chen, H Chen, M Guan, NE Lane |
PloS one | 2010 |
The effect of zoledronate during bone healing
MA Matos, U Tannuri, R Guarniero |
Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology | 2010 |
Management of glucocorticoid-induced osteoporosis: prevalence, and emerging treatment options
J Payer, K Brazdilova, P Jackuliak |
Drug, healthcare and patient safety | 2010 |
Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo
S Lymperi, A Ersek, F Ferraro, F Dazzi, NJ Horwood |
Blood | 2010 |
Gap Junctions and Biophysical Regulation of Bone Cells
SA Lloyd, HJ Donahue |
Clinical Reviews in Bone and Mineral Metabolism | 2010 |
Effect of Risedronate on Osteocyte Viability and Bone Turnover in Paired Iliac Bone Biopsies from Early Postmenopausal Women
S Qiu, RJ Phipps, FH Ebetino, S Palnitkar, DS Rao |
Calcified Tissue International | 2010 |
Effects of Vitamin K2 on Cortical and Cancellous Bone Mass, Cortical Osteocyte and Lacunar System, and Porosity in Sciatic Neurectomized Rats
J Iwamoto, H Matsumoto, T Takeda, Y Sato, JK Yeh |
Calcified Tissue International | 2010 |
Osteonecrosis of the Jaw and the Role of Macrophages
M Pazianas |
JNCI Journal of the National Cancer Institute | 2010 |
Are All Bisphosphonates the Same? Potential Reasons for Clinical Differences: A Perspective
JA Simon |
Journal of Women's Health | 2010 |
Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment
MS Ironside, MJ Duer, DG Reid, S Byard |
European Journal of Pharmaceutics and Biopharmaceutics | 2010 |
2009 Santa Fe Bone Symposium
EM Lewiecki, JP Bilezikian, AJ Laster, PD Miller, RR Recker, RG Russell, MP Whyte |
Journal of Clinical Densitometry | 2010 |
A Sustained Release of Lovastatin from Biodegradable, Elastomeric Polyurethane Scaffolds for Enhanced Bone Regeneration
T Yoshii, AE Hafeman, JS Nyman, JM Esparza, K Shinomiya, DM Spengler, GR Mundy, GE Gutierrez, SA Guelcher |
Tissue Engineering Part A | 2010 |
Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis
O Brennan, OD Kennedy, TC Lee, SM Rackard, FJ O'Brien |
Journal of Orthopaedic Research | 2010 |
Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone
CP Lau, L Huang, SK Tsui, PK Ng, PY Leung, SM Kumta |
Journal of Orthopaedic Research | 2010 |
Mechanical Induction of PGE2 in Osteocytes Blocks Glucocorticoid-Induced Apoptosis Through Both the β-Catenin and PKA Pathways
Y Kitase, L Barragan, H Qing, S Kondoh, JX Jiang, ML Johnson, LF Bonewald |
Journal of Bone and Mineral Research | 2010 |
Effects of clodronate combined with hydroxyapatite on multi-directional differentiation of mesenchymal stromal cells
X Liu, C Bao, J Hu, G Yin, E Luo |
Archives of Medical Science : AMS | 2010 |
Effect of Alendronate on Pseudomembrane Cytokine Expression in Patients with Aseptic Osteolysis
G Holt, J Reilly, RM Meek |
The Journal of Arthroplasty | 2010 |
Validity of prevention of glucocorticoid-induced alveolar bone loss in rat by either calcitonin or alendronate administration
BA Ezzat |
Archives of Oral Biology | 2010 |
The Molecular Biology of Sex Steroids in Bone
S Kousteni |
Osteoporosis in Men | 2010 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model
JA Cottrell, FM Vales, D Schachter, S Wadsworth, R Gundlapalli, R Kapadia, JP O'Connor |
Journal of Biomedicine and Biotechnology | 2010 |
Inhibition of the Progesterone Nuclear Receptor during the Bone Linear Growth Phase Increases Peak Bone Mass in Female Mice
W Yao, W Dai, M Shahnazari, A Pham, Z Chen, H Chen, M Guan, NE Lane, JA Calbet |
PloS one | 2010 |
Bisphosphonates in the treatment of metabolic bone diseases
HP Arantes, AG da Silva, M Lazaretti-Castro |
Arquivos brasileiros de endocrinologia e metabologia | 2010 |
EFFECTS OF PHYSICAL EXERCISE ON FEMORAL BONE MINERAL DENSITY AND OSTEOCYTE MICROMORPHOLOGY IN YOUNG OVARIECTOMIZED (OVX) RATS
T Kawakami, S Takise, H Kawata |
Japanese Journal of Physical Fitness and Sports Medicine | 2010 |
The effect of the alendronate on OPG/RANKL system in differentiated primary human osteoblasts
A Enjuanes, S Ruiz-Gaspà, P Peris, D Ozalla, L Álvarez, A Combalia, MJ de Osaba, A Monegal, A Pares, N Guañabens |
Endocrine | 2010 |
Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice
RS Weinstein, C Wan, Q Liu, Y Wang, M Almeida, CA O'Brien, J Thostenson, PK Roberson, AL Boskey, TL Clemens, SC Manolagas |
Aging Cell | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha
M Almeida, M Martin-Millan, E Ambrogini, RB 3rd, L Han, XD Chen, PK Roberson, RS Weinstein, CA O'Brien, RL Jilka, SC Manolagas |
Journal of Bone and Mineral Research | 2009 |
Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice
H Sekiya, T Murakami, A Saito, S Hino, K Tsumagari, K Ochiai, K Imaizumi |
Journal of Bone and Mineral Metabolism | 2009 |
Transcriptome and Proteome Analysis of Osteocytes Treated with Nitrogen-Containing Bisphosphonates
N Bivi, JZ Bereszczak, M Romanello, LA Zeef, D Delneri, F Quadrifoglio, L Moro, FL Brancia, G Tell |
Journal of Proteome Research | 2009 |
Modulation of murine bone marrow-derived CFU-F and CFU-OB byin vivobisphosphonate and fluoride treatments
MY Chou, D Yan, T Jafarov, ET Everett |
Orthodontics & Craniofacial Research | 2009 |
Bisphosphonates and BMU birth rate: response to comments by Ott
E Seeman |
Osteoporosis International | 2009 |
Mandibular necrosis in beagle dogs treated with bisphosphonates
DB Burr, MR Allen |
Orthodontics & Craniofacial Research | 2009 |
In vivo Performance of Osteoactivated Cellulose-Based Scaffolds in Bony Critical-Size Defects
S Ponader, H Brandt, E Vairaktaris, C Wilmowsky, W Göthel, R Lutz, KA Schlegel, FW Neukam, P Greil, FA Müller, E Nkenke |
Advanced Engineering Materials | 2009 |
The effect of the alendronate on OPG/RANKL system in differentiated primary human osteoblasts
A Enjuanes, S Ruiz-Gaspà, P Peris, D Ozalla, L Álvarez, A Combalia, MJ de Osaba, A Monegal, A Pares, N Guañabens |
Endocrine | 2009 |
Suppressive effect of dexamethasone on TIMP-1 production involves murine osteoblastic MC3T3-E1 cell apoptosis
H Xie, LL Tang, XH Luo, XY Wu, XP Wu, HD Zhou, LQ Yuan, EY Liao |
Amino Acids | 2009 |
Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings
S Hoefert, I Schmitz, A Tannapfel, H Eufinger |
Clinical Oral Investigations | 2009 |
Timing, rather than the concentration of cyclic AMP, correlates to osteogenic differentiation of human mesenchymal stem cells
R Siddappa, J Doorn, J Liu, E Langerwerf, R Arends, C Blitterswijk, J Boer |
Journal of Tissue Engineering and Regenerative Medicine | 2009 |
Why to Keep Osteocytes Alive and How?
T Bellido |
Journal of Korean Endocrine Society | 2009 |
Alendronate augments interleukin-1β release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1
X Deng, R Tamai, Y Endo, Y Kiyoura |
Toxicology and Applied Pharmacology | 2009 |
Effects of Bisphosphonate on Bone Metabolism of Growing Rat Tibia in Glucocorticoid-Induced Osteoporosis
K Hasegawa, K Maki |
The Journal of the Kyushu Dental Society | 2009 |
Incidence of bisphosphonate-associated osteonecrosis of the jaws in breast cancer patients
C Walter, B Al-Nawas, A Bois, L Buch, P Harter, KA Grötz |
Cancer | 2009 |
In vitrokinetic study of growth and mineralization of osteoblast-like cells (Saos-2) on titanium surface coated with a RGD functionalized bisphosphonate
J Beuvelot, D Portet, G Lecollinet, MF Moreau, MF Baslé, D Chappard, H Libouban |
Journal of Biomedical Materials Research Part B: Applied Biomaterials | 2009 |
Alendronate Improves Low Bone Mineral Density Induced by Steroid Therapy in Crohn's Disease
T Tsujikawa, A Andoh, O Inatomi, S Bamba, T Nakahara, M Sasaki, H Saito, Y Fujiyama |
Internal Medicine | 2009 |
Glucocorticoid-induced osteoporosis: hope on the HORIZON
L Gennari, JP Bilezikian |
The Lancet | 2009 |
The Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaw: So Many Hypotheses, So Few Data
MR Allen, DB Burr |
Journal of Oral and Maxillofacial Surgery | 2009 |
Alternative Indications for Bisphosphonate Therapy
R Landesberg, S Eisig, I Fennoy, E Siris |
Journal of Oral and Maxillofacial Surgery | 2009 |
Hipercalcemia del adulto
MH Vieillard, I Gerot-Legroux, B Cortet |
EMC - Aparato Locomotor | 2009 |
Hypercalcémie de l'adulte
MH Vieillard, I Gerot-Legroux, B Cortet |
EMC - Appareil locomoteur | 2009 |
Weekly clodronate treatment prevents bone loss and vertebral fractures in women with subclinical Cushing’s syndrome
L Tauchmanova, E Guerra, R Pivonello, MC Martino, M Leo, F Caggiano, G Lombardi, A Colao |
Journal of Endocrinological Investigation | 2009 |
The Antiresorptive Effects of a Single Dose of Zoledronate Persist for Two Years: A Randomized, Placebo-Controlled Trial in Osteopenic Postmenopausal Women
A Grey, MJ Bolland, D Wattie, A Horne, G Gamble, IR Reid |
The Journal of clinical endocrinology and metabolism | 2009 |
Weekly clodronate treatment prevents bone loss and vertebral fractures in women with subclinical Cushing’s syndrome
L Tauchmanova, E Guerra, R Pivonello, MC Martino, MD Leo, F Caggiano, G Lombardi, A Colao |
Journal of Endocrinological Investigation | 2009 |
Osteoporosis
JJ Westendorf |
Osteoporosis International | 2008 |
Osteoporosis
JJ Westendorf |
Osteoporosis International | 2008 |
Osteoporosis
JJ Westendorf |
Osteoporosis International | 2008 |
Osteoporosis
JJ Westendorf |
Osteoporosis International | 2008 |
Osteoporosis
JJ Westendorf |
Osteoporosis International | 2008 |
Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents
T Yamaza, Y Miura, Y Bi, Y Liu, K Akiyama, W Sonoyama, V Patel, S Gutkind, M Young, S Gronthos, A Le, CY Wang, WJ Chen, S Shi |
PloS one | 2008 |
Risk Factors, Prevention, and Treatment of Corticosteroid-Induced Osteoporosis in Adults
KM Ruf, NK Johnson, T Clifford, KM Smith |
Orthopedics | 2008 |
Alendronate Enhances Osteogenic Differentiation of Bone Marrow Stromal Cells: A Preliminary Study
HK Kim, JH Kim, AA Abbas, TR Yoon |
Clinical Orthopaedics and Related Research® | 2008 |
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
RG Russell, NB Watts, FH Ebetino, MJ Rogers |
Osteoporosis International | 2008 |
The Effects of Systemic Alendronate With or Without Intraalveolar Collagen Sponges on Postextractive Bone Resorption
F Graziani, S Rosini, S Cei, FL Ferla, M Gabriele |
Journal of Craniofacial Surgery | 2008 |
Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro
AI Idris, J Rojas, IR Greig, RJ Hof, SH Ralston |
Calcified Tissue International | 2008 |
Bisphosphonates: how do they work?
SE Papapoulos |
Best Practice & Research Clinical Endocrinology & Metabolism | 2008 |
Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo
LI Plotkin, V Lezcano, J Thostenson, RS Weinstein, SC Manolagas, T Bellido |
Journal of Bone and Mineral Research | 2008 |
Regulation of bim in glucocorticoid-mediated osteoblast apoptosis
B Espina, M Liang, RG Russell, PA Hulley |
Journal of Cellular Physiology | 2008 |
Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite
SJ Suratwala, SK Cho, JJ van Raalte, SH Park, SW Seo, SS Chang, TR Gardner, FY Lee |
The Journal of bone and joint surgery. American volume | 2008 |
Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment
MR Allen, DB Burr |
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | 2008 |
Bisphosphonates: mechanism of action and role in clinical practice
MT Drake, BL Clarke, S Khosla |
Mayo Clinic proceedings. Mayo Clinic | 2008 |
Calcitonin Promotes Outgrowth of Trophoblast Cells on Endometrial Epithelial Cells: Involvement of Calcium Mobilization and Protein Kinase C Activation
HY Li, JT Shen, SP Chang, WL Hsu, YJ Sung |
Placenta | 2008 |
In vitro response of hFOB cells to pamidronate modified sodium silicate coated cellulose scaffolds
S Ponader, H Brandt, E Vairaktaris, C Wilmowsky, E Nkenke, KA Schlegel, FW Neukam, S Holst, FA Müller, P Greil |
Colloids and Surfaces B: Biointerfaces | 2008 |
Prevention of strain-related osteopenia in aseptic loosening of hip prostheses using perioperative bisphosphonate
AE Goodship, GW Blunn, J Green, MJ Coathup |
Journal of Orthopaedic Research | 2008 |
Connexin43 Modulation of Osteoblast/Osteocyte Apoptosis: A Potential Therapeutic Target?
R Civitelli |
Journal of Bone and Mineral Research | 2008 |
Association of low-energy femoral fractures with prolonged bisphosphonate use: a case control study
BA Lenart, AS Neviaser, S Lyman, CC Chang, F Edobor-Osula, B Steele, MC Meulen, DG Lorich, JM Lane |
Osteoporosis International | 2008 |
Beneficial Effects of Combined Administration of Alendronate and Alfacalcidol on Cancellous Bone Mass of the Tibia in Orchidectomized Rats: A Bone Histomorphometry Study
J IWAMOTO, T TAKEDA, H MATSUMOTO, Y SATO, JK YEH |
Journal of Nutritional Science and Vitaminology | 2008 |
Bisphosphonatassoziierte Nekrosen der Kiefer
D Hermes, P Beier, K Peters |
Der Onkologe | 2008 |
Effects of Vitamin K2 and Risedronate on Bone Formation and Resorption, Osteocyte Lacunar System, and Porosity in the Cortical Bone of Glucocorticoid-Treated Rats
J Iwamoto, H Matsumoto, T Takeda, Y Sato, X Liu, JK Yeh |
Calcified Tissue International | 2008 |
Radiologic and Serologic Features of Extensive Venous Malformations Associated with Atrophy, Osteoporosis, and Visceral Involvement: Implications for Future Management
P Redondo, G Bastarrika |
Dermatologic Surgery | 2008 |
Optimum management of glucocorticoid-treated patients
S Trikudanathan, GT McMahon |
Nature Clinical Practice Endocrinology & Metabolism | 2008 |
Stimulation of osteogenic differentiation and inhibition of adipogenic differentiation in bone marrow stromal cells by alendronate via ERK and JNK activation
L Fu, T Tang, Y Miao, S Zhang, Z Qu, K Dai |
Bone | 2008 |
Calculating clinically relevant drug doses to use in animal studies
RK Fuchs, MR Allen, KW Condon, S Reinwald, LM Miller, D McClenathan, B Keck, RJ Phipps, DB Burr |
Osteoporosis International | 2008 |
Differential Response of Risedronate on Tibial and Mandibular Bone Quality in Glucocorticoid-treated Growing Rats
Y Fujita |
The Journal of the Kyushu Dental Society | 2008 |
Effect of progesterone on apoptosis of murine MC3T3-E1 osteoblastic cells
QP Wang, H Xie, LQ Yuan, XH Luo, H Li, D Wang, P Meng, EY Liao |
Amino Acids | 2008 |
Stainless steel screws coated with bisphosphonates gave stronger fixation and more surrounding bone. Histomorphometry in rats
K Wermelin, F Suska, P Tengvall, P Thomsen, P Aspenberg |
Bone | 2008 |
Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells
MV Gangoiti, AM Cortizo, V Arnol, JI Felice, AD McCarthy |
European Journal of Pharmacology | 2008 |
Effects of alendronate and pamidronate on cultured rat metatarsal bones: Failure to prevent dexamethasone-induced growth retardation
TJ Heino, AS Chagin, M Takigawa, L Sävendahl |
Bone | 2008 |
Histomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits
AA Pampu, D Dolanmaz, HH Tüz, MC Avunduk, RŞ Kisşnisşci |
Journal of Oral and Maxillofacial Surgery | 2008 |
Zoledronic acid – does it have anabolic as well as anti-resorptive effects?
JE Compston |
IBMS BoneKEy | 2008 |
An update on the pharmacology of bisphosphonates and analogues with lower bone affinity
FP Coxon |
IBMS BoneKEy | 2008 |
Bisphosphonates: Mechanism of Action and Role in Clinical Practice
MT Drake, BL Clarke, S Khosla |
Mayo Clinic Proceedings | 2008 |
Principles of Bone Biology
CJ Rosen, T Niu |
Principles of Bone Biology | 2008 |
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
FP Coxon, K Thompson, AJ Roelofs, FH Ebetino, MJ Rogers |
Bone | 2008 |
Treatment of Renal Transplant Recipients With Low Bone Mineral Density: A Randomized Prospective Trial of Alendronate, Alfacalcidol, and Alendronate Combined With Alfacalcidol
S Trabulus, MR Altiparmak, S Apaydin, K Serdengecti, M Sariyar |
Transplantation Proceedings | 2008 |
Pharmacologic Stem Cell Based Intervention as a New Approach to Osteoporosis Treatment in Rodents
T Yamaza, Y Miura, Y Bi, Y Liu, K Akiyama, W Sonoyama, V Patel, S Gutkind, M Young, S Gronthos, A Le, CY Wang, WJ Chen, S Shi, T Zwaka |
PloS one | 2008 |
Enhancement of Periprosthetic Bone Quality with Topical Hydroxyapatite-Bisphosphonate Composite:
SJ Suratwala, SK Cho, JJ van Raalte, SH Park, SW Seo, SS Chang, TR Gardner, FY Lee |
The Journal of Bone and Joint Surgery. American volume. | 2008 |
Parathyroid hormone mediates bone growth through the regulation of osteoblast proliferation and differentiation
GJ Pettway, JA Meganck, AJ Koh, ET Keller, SA Goldstein, LK McCauley |
Bone | 2007 |
Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
AE Kearns, S Khosla, PJ Kostenuik |
Endocrine reviews | 2007 |
Salmon calcitonin: a review of current and future therapeutic indications
CH Chesnut, M Azria, S Silverman, M Engelhardt, M Olson, L Mindeholm |
Osteoporosis International | 2007 |
The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoids
G Balooch, W Yao, JW Ager, M Balooch, RK Nalla, AE Porter, RO Ritchie, NE Lane |
Arthritis & Rheumatism | 2007 |
Effect of raloxifene treatment on osteocyte apoptosis in postmenopausal women
HW van Essen, PJ Holzmann, MA Blankenstein, P Lips, N Bravenboer |
Calcified Tissue International | 2007 |
Calcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritis
L Mancini, MJ Paul-Clark, G Rosignoli, R Hannon, JE Martin, I Macintyre, M Perretti |
The American Journal of Pathology | 2007 |
Signaling and transcriptional regulation in osteoblast commitment and differentiation
Huang W, Yang S, Shao J, Li YP |
Frontiers in bioscience : a journal and virtual library | 2007 |
Effects of antifracture drugs in postmenopausal, male and glucocorticoid-induced osteoporosis – usefulness of alendronate and risedronate
J Iwamoto, T Takeda, Y Sato |
Expert Opinion on Pharmacotherapy | 2007 |
The Molecular Mechanisms of Action of Bisphosphonates
K Thompson, MJ Rogers |
Clinical Reviews in Bone and Mineral Metabolism | 2007 |
Anabolic effects of bisphosphonates on peri-implant bone stock
F Knoch, C Eckhardt, CI Alabre, E Schneider, HE Rubash, AS Shanbhag |
Biomaterials | 2007 |
Alendronate Has an Anabolic Effect on Bone Through the Differentiation of Mesenchymal Stem Cells
G Duque, D Rivas |
Journal of Bone and Mineral Research | 2007 |
Addition of bisphosphonate to antibiotic and anti-inflammatory treatment reduces bone resorption in experimentalStaphylococcus aureus-induced arthritis
M Verdrengh, H Carlsten, C Ohlsson, A Tarkowski |
Journal of Orthopaedic Research | 2007 |
Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo
MM Conradie, H Wet, DD Kotze, JM Burrin, FS Hough, PA Hulley |
The Journal of endocrinology | 2007 |
Alendronate inhibits PTH (1-34)-induced bone morphogenetic protein expression in MC3T3-E1 preosteoblastic cells
PS Issack, MH Lauerman, DL Helfet, SB Doty, JM Lane |
HSS journal : the musculoskeletal journal of Hospital for Special Surgery | 2007 |
Alendronate increases BMD at appendicular and axial skeletons in patients with established osteoporosis
L Qin, W Choy, S Au, M Fan, P Leung |
Journal of orthopaedic surgery and research | 2007 |
Einfluss der Bisphosphonate auf die Frakturheilung
C Seebach, A Kurth, I Marzi |
Der Orthopäde | 2007 |
Successful treatment of avascular bone necrosis of the knee with neridronate: a case report
A Corrado, L Quarta, S Errico, FP Cantatore |
Rheumatology International | 2007 |
Perspective: Quantifying Osteoblast and Osteocyte Apoptosis: Challenges and Rewards
RL Jilka, RS Weinstein, AM Parfitt, SC Manolagas |
Journal of Bone and Mineral Research | 2007 |
Drug Insight: the use of bisphosphonates for the prevention and treatment of osteoporosis in men
SA Brown, TA Guise |
Nature Clinical Practice Urology | 2007 |
Malformaciones vasculares (II). Diagnóstico, histopatología y tratamiento
P Redondo |
Actas Dermo-Sifiliográficas | 2007 |
Potential of calcitonin as a novel cotreatment for arthritis
M Perretti, L Mancini |
Future Rheumatology | 2007 |
l-Carnitine protects against apoptosis of murine MC3T3-E1 osteoblastic cells
H Xie, SY Tang, H Li, XH Luo, LQ Yuan, D Wang, EY Liao |
Amino Acids | 2007 |
Biological options to enhance periprosthetic bone mass
E Tsiridis, Z Gamie, PG Conaghan, PV Giannoudis |
Injury | 2007 |
Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading
H Follet, J Li, RJ Phipps, S Hui, K Condon, DB Burr |
Bone | 2007 |
Effect of local delivery of alendronate on bone formation in bioactive glass grafting in rats
S Srisubut, A Teerakapong, T Vattraphodes, S Taweechaisupapong |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2007 |
Serum OPG and RANKL levels before and after intravenous bisphosphonate treatment in Paget's disease of bone
G Martini, L Gennari, D Merlotti, S Salvadori, MB Franci, S Campagna, A Avanzati, VD Paola, F Valleggi, R Nuti |
Bone | 2007 |
Osteonecrosis. What Is New?
MÁ Martínez-Ferrer, P Peris, N Guañabens |
Reumatolog ía Cl ínica (English Edition) | 2007 |
Osteocyte apoptosis induces bone resorption and impairs the skeletal response to weightlessness
T Bellido |
BoneKEy-Osteovision | 2007 |
Vascular malformations (II). Diagnosis, Pathology, and Treatment
P Redondo |
Actas Dermo-Sifiliográficas (English Edition) | 2007 |
Osteonecrosis. ¿Qué hay de nuevo?
MÁ Martínez-Ferrer, P Peris, N Guañabens |
Reumatología Clínica | 2007 |
Risedronate prevents the loss of microarchitecture in glucocorticoid-induced osteoporosis in rats
LD Carbonare, F Bertoldo, MT Valenti, S Zordan, S Sella, A Fassina, G Turco, G Realdi, VL Cascio, S Giannini |
Journal of Endocrinological Investigation | 2007 |
Signaling and transcriptional regulation in osteoblast commitment and differentiation
W Huang, S Yang, J Shao, YP Li |
Frontiers in bioscience : a journal and virtual library | 2007 |
Alendronate Improves Screw Fixation in Osteoporotic Bone:
A Moroni, C Faldini, A Hoang-Kim, F Pegreffi, S Giannini |
The Journal of Bone and Joint Surgery. American volume. | 2007 |
Glucocorticoids Induce Osteocyte Apoptosis by Blocking Focal Adhesion Kinase-mediated Survival: EVIDENCE FOR INSIDE-OUT SIGNALING LEADING TO ANOIKIS
LI Plotkin, SC Manolagas, T Bellido |
The Journal of biological chemistry | 2007 |
Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates
DB Kimmel |
Journal of dental research | 2007 |
The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases
S Omoigui |
Immunity & Ageing | 2007 |
REVIEW: Bone Loss and Its Management in Long-Term Survivors from Allogeneic Stem Cell Transplantation
L Tauchmanovà, A Colao, G Lombardi, B Rotoli, C Selleri |
The Journal of clinical endocrinology and metabolism | 2007 |
Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss
JI Aguirre, LI Plotkin, SA Stewart, RS Weinstein, AM Parfitt, SC Manolagas, T Bellido |
Journal of Bone and Mineral Research | 2006 |
Ca2+-Dependent Regulation of Calcitonin Gene Expression by the Transcriptional Repressor DREAM
M Matsuda, T Yamamoto, M Hirata |
Endocrinology | 2006 |
Glucocorticosteroid-induced spinal osteoporosis: scientific update on pathophysiology and treatment
AW Popp, J Isenegger, EM Buergi, U Buergi, K Lippuner |
European Spine Journal | 2006 |
Nothing but skin and bone
FP Ross, AM Christiano |
Journal of Clinical Investigation | 2006 |
Glucocorticoid-induced Osteoporosis and Its Treatment
P Pennisi, A Trombetti, R Rizzoli |
Clinical Orthopaedics and Related Research | 2006 |
The Pathogenesis, Epidemiology and Management of Glucocorticoid-Induced Osteoporosis
TP Staa |
Calcified Tissue International | 2006 |
Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate
X Deng, Z Yu, H Funayama, N Shoji, T Sasano, Y Iwakura, S Sugawara, Y Endo |
Toxicology and Applied Pharmacology | 2006 |
Antiremodeling Agents Influence Osteoblast Activity Differently in Modeling and Remodeling Sites of Canine Rib
MR Allen, H Follet, M Khurana, M Sato, DB Burr |
Calcified Tissue International | 2006 |
Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs
LI Plotkin, SC Manolagas, T Bellido |
Bone | 2006 |
Ibandronate: Pharmacology and preclinical studies
RG Russell |
Bone | 2006 |
Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients
H Dobnig, LC Hofbauer, V Viereck, B Obermayer-Pietsch, A Fahrleitner-Pammer |
Osteoporosis International | 2006 |
The Effects of Antifracture Therapies on the Components of Bone Strength: Assessment of Fracture Risk Today and in the Future
KS Davison, K Siminoski, JD Adachi, DA Hanley, D Goltzman, AB Hodsman, R Josse, S Kaiser, WP Olszynski, A Papaioannou, LG Ste-Marie, DL Kendler, A Tenenhouse, JP Brown |
Seminars in Arthritis and Rheumatism | 2006 |
Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody
S Kamijo, A Nakajima, K Ikeda, K Aoki, K Ohya, H Akiba, H Yagita, K Okumura |
Biochemical and Biophysical Research Communications | 2006 |
Nekrosen der Kieferknochen unter Bisphosphonattherapie
S Hoefert, H Eufinger |
Der Orthopäde | 2006 |
Osteoporosis prevention and therapy: preserving and building strength through bone quality
M Kleerekoper |
Osteoporosis International | 2006 |
Advances in the management of corticosteroid-induced osteoporosis with bisphosphonates
JD Ringe, P Farahmand |
Clinical Rheumatology | 2006 |
The role of osteocytes and bone microstructure in preventing osteoporotic fractures
JG Hazenberg, D Taylor, TC Lee |
Osteoporosis International | 2006 |
Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia
K Iwata, J Li, H Follet, RJ Phipps, DB Burr |
Bone | 2006 |
Drug Insight: bisphosphonates for postmenopausal osteoporosis
RD Chapurlat, PD Delmas |
Nature Clinical Practice Endocrinology & Metabolism | 2006 |
Systemic Lupus Erythematosus
M Petri |
JCR: Journal of Clinical Rheumatology | 2006 |
Effect of systemic glucocorticoid therapy on bone metabolism: an update
MS Cooper |
Expert Review of Endocrinology & Metabolism | 2006 |
Apelin suppresses apoptosis of human osteoblasts
H Xie, LQ Yuan, XH Luo, J Huang, RR Cui, LJ Guo, HD Zhou, XP Wu, EY Liao |
Apoptosis | 2006 |
A rapid, high content,in vivo model of glucocorticoid-induced osteoporosis
R Barrett, C Chappell, M Quick, A Fleming |
Biotechnology Journal | 2006 |
Effect of Topical Alendronate Treatment on Fixation of Implants Inserted with Bone Compaction
T Jakobsen, S Kold, JE Bechtold, B Elmengaard, K S??balle |
Clinical Orthopaedics and Related Research | 2006 |
Osteogenic growth peptide effects on primary human osteoblast cultures: Potential relevance for the treatment of glucocorticoid-induced osteoporosis
A Spreafico, B Frediani, C Capperucci, A Leonini, D Gambera, P Ferrata, S Rosini, AD Stefano, M Galeazzi, R Marcolongo |
Journal of Cellular Biochemistry | 2006 |
Association Between Osteonecrosis of the Jaws and Chronic High-Dosage Intravenous Bisphosphonates Therapy
F Graziani, S Cei, FL Ferla, E Cerri, A Itro, M Gabriele |
Journal of Craniofacial Surgery | 2006 |
A20 overexpression under control of mouse osteocalcin promoter in MC3T3-E1 cells inhibited tumor necrosis factor-alpha-induced apoptosis
Y QIN, Z ZHANG, L YU, J HE, Y HOU, T LIU, J WU, S WU, L GUO |
Acta Pharmacologica Sinica | 2006 |
Postmenopausal osteoporosis. What have we learned since the introduction of bisphosphonates?
S Chaiamnuay, KG Saag |
Reviews in Endocrine and Metabolic Disorders | 2006 |
Osteogenic activity of vanadyl(IV)–ascorbate complex: Evaluation of its mechanism of action
AM Cortizo, MS Molinuevo, DA Barrio, L Bruzzone |
The International Journal of Biochemistry & Cell Biology | 2006 |
Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines
M Romanello, N Bivi, A Pines, M Deganuto, F Quadrifoglio, L Moro, G Tell |
Bone | 2006 |
Alendronate or Alfacalcidol in Glucocorticoid-Induced Osteoporosis
RN de Nijs, JW Jacobs, WF Lems, RF Laan, A Algra, AM Huisman, E Buskens, CE de Laet, AC Oostveen, PP Geusens, GA Bruyn, BA Dijkmans, JW Bijlsma |
New England Journal of Medicine | 2006 |
Choreography from the tomb: An emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling
SC Manolagas |
BoneKEy-Osteovision | 2006 |
Dynamics of Bone and Cartilage Metabolism
JE Mulder, CA Kulak, E Shane |
Dynamics of Bone and Cartilage Metabolism | 2006 |
Glucocorticoid-induced Osteoporosis and Its Treatment:
P Pennisi, A Trombetti, R Rizzoli |
Clinical Orthopaedics and Related Research | 2006 |
Rubus coreanus Miq. Extract Promotes Osteoblast Differentiation and Inhibits Bone-Resorbing Mediators in MC3T3-E1 Cells
KH Lee, EM Choi |
The American journal of Chinese medicine | 2006 |
Prise en charge de l’ostéoporose cortisonique
P Orcel |
La Presse Médicale | 2006 |
Les bisphosphonates oraux dans le traitement de l'ostéoporose postménopausique
T Thomas, V Breuil, K Briot |
Revue du Rhumatisme | 2006 |
Use of Bisphosphonates to Improve the Durability of Total Joint Replacements:
AS Shanbhag |
The Journal of the American Academy of Orthopaedic Surgeons | 2006 |
Bisphosphonates: From Bench to Bedside
RG Russell |
Annals of the New York Academy of Sciences | 2006 |
Molekularmedizinische Grundlagen von para- und autokrinen Regulationsstörungen
D Ganten, K Ruckpaul, J Köhrle |
2006 | |
Osteonekrose der Kiefer unter Bisphosphonat-Langzeittherapie
JU Piesold, B Al-Nawas, KA Grötz |
Mund- Kiefer- und Gesichtschirurgie | 2006 |
Parathyroid Hormone as an Anabolic Skeletal Therapy:
MR Rubin, JP Bilezikian |
Drugs | 2005 |
Alternative bisphosphonate targets and mechanisms of action
JF Bukowski, CC Dascher, H Das |
Biochemical and Biophysical Research Communications | 2005 |
Histomorphometric analysis of glucocorticoid-induced osteoporosis
LD Carbonare, F Bertoldo, MT Valenti, S Zenari, M Zanatta, S Sella, S Giannini, VL Cascio |
Micron | 2005 |
The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats
H Kajiwara, T Yamaza, M Yoshinari, T Goto, S Iyama, I Atsuta, MA Kido, T Tanaka |
Biomaterials | 2005 |
Bisphosphonate Modulates Cementoblast Behavior In Vitro
YH Chun, BL Foster, PA Lukasavage, JE Berry, M Zhao, HC Tenenbaum, MJ Somerman |
Journal of Periodontology | 2005 |
The decrease of particle-induced osteolysis after a single dose of bisphosphonate
M Knoch, C Wedemeyer, A Pingsmann, F Knoch, G Hilken, C Sprecher, F Henschke, B Barden, F Löer |
Biomaterials | 2005 |
Clinical Pharmacology of Potent New Bisphosphonates for Postmenopausal Osteoporosis
RD Chapurlat |
Treatments in Endocrinology | 2005 |
The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K-Akt-NFkappaB pathway in osteosarcoma cells
R Inoue, N Matsuki, G Jing, T Kanematsu, K Abe, M Hirata |
British Journal of Pharmacology | 2005 |
Prevention and treatment of corticosteroid-induced osteoporosis
J Iwamoto, T Takeda, Y Sato |
Yonsei Medical Journal | 2005 |
Regulation of apoptosis in osteoclasts and osteoblastic cells
L Xing, BF Boyce |
Biochemical and Biophysical Research Communications | 2005 |
Tiludronate inhibits prostaglandin F2α-induced vascular endothelial growth factor synthesis in osteoblasts
M Yoshida, H Tokuda, A Ishisaki, Y Kanno, A Harada, K Shimuzu, O Kozawa |
Molecular and Cellular Endocrinology | 2005 |
Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis
G Gu, TA Hentunen, M Nars, PL Härkönen, HK Väänänen |
Apoptosis | 2005 |
Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells
F Knoch, C Jaquiery, M Kowalsky, S Schaeren, C Alabre, I Martin, HE Rubash, AS Shanbhag |
Biomaterials | 2005 |
Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response
A Costessi, A Pines, P D'Andrea, M Romanello, G Damante, L Cesaratto, F Quadrifoglio, L Moro, G Tell |
Bone | 2005 |
In whom and how to prevent glucocorticoid-induced osteoporosis
JD Adachi, A Papaioannou |
Best Practice & Research Clinical Rheumatology | 2005 |
Ein Vergleich der antiresorptiven Effekte von Bisphosphonaten und Statinen auf Polyethylenpartikel-induzierte Osteolysen /A Comparison of the Antiresorptive Effects of Bisphosphonates and Statins on Polyethylene Particle-Induced Osteolysis
F Knoch, C Wedemeyer, A Heckelei, C Sprecher, G Saxler, G Hilken, F Henschke, H Bereiter, F Löer, M Knoch |
Biomedizinische Technik/Biomedical Engineering | 2005 |
Apoptosis in glucocorticoid-induced bone disease
RS Weinstein, SC Manolagas |
Current Opinion in Internal Medicine | 2005 |
Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival
EC Seales, KJ Micoli, JM McDonald |
Journal of Cellular Biochemistry | 2005 |
Kieferknochennekrosen als mögliche unerwünschte Wirkung von Bisphosphonaten
S Hoefert, H Eufinger |
Mund-, Kiefer- und Gesichtschirurgie | 2005 |
Effects of various antireabsorptive treatments on bone mineral density in hypogonadal young women after allogeneic stem cell transplantation
L Tauchmanovà, GD Simone, T Musella, F Orio, P Ricci, C Nappi, G Lombardi, A Colao, B Rotoli, C Selleri |
Bone Marrow Transplantation | 2005 |
Stimulation of bone formation by zoledronic acid in particle-induced osteolysis
C Wedemeyer, F Knoch, A Pingsmann, G Hilken, C Sprecher, G Saxler, F Henschke, F Löer, M Knoch |
Biomaterials | 2005 |
The effect of simvastatin on polyethylene particle-induced osteolysis
F Knoch, A Heckelei, C Wedemeyer, G Saxler, G Hilken, F Henschke, F Löer, M Knoch |
Biomaterials | 2005 |
Promotion of bone formation by simvastatin in polyethylene particle-induced osteolysis
F Knoch, C Wedemeyer, A Heckelei, G Saxler, G Hilken, J Brankamp, T Sterner, S Landgraeber, F Henschke, F Löer, M Knoch |
Biomaterials | 2005 |
Bone Healing in Children With Osteogenesis Imperfecta Treated With Bisphosphonates
J Pizones, H Plotkin, JI Parra-Garcia, P Alvarez, P Gutierrez, A Bueno, A Fernandez-Arroyo |
Journal of Pediatric Orthopaedics | 2005 |
Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration
B Peter, DP Pioletti, S Laïb, B Bujoli, P Pilet, P Janvier, J Guicheux, PY Zambelli, JM Bouler, O Gauthier |
Bone | 2005 |
Prevention and treatment of glucocorticoid-induced osteoporosis in 2005
P Orcel |
Joint Bone Spine | 2005 |
Bone Disease of Organ Transplantation
MR Rubin, JP Billezkian |
Bone Disease of Organ Transplantation | 2005 |
Prise en charge de l'ostéoporose cortisonique en 2005
P Orcel |
Revue du Rhumatisme | 2005 |
The influence of alendronate on bone formation after autogenous free bone grafting in rats
H Altundal, B Gursoy |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2005 |
Effects of neridronate treatment in elderly women with osteoporosis
T Cascella, T Musella, F Orio, S Palomba, G Bifulco, C Nappi, G Lombardi, A Colao, L Tauchmanova |
Journal of Endocrinological Investigation | 2005 |
The inhibitory effect of bisphosphonates on glucocorticoid‐induced RANKL expression in human cells
A Kobayashi, F Hirano, I Makino |
Scandinavian Journal of Rheumatology | 2005 |
Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
LI Plotkin, I Mathov, JI Aguirre, AM Parfitt, SC Manolagas, T Bellido |
American journal of physiology. Cell physiology | 2005 |
Morbus Bechterew
A Felkenbach |
2005 | |
Bone Resorption
F Bronner, MC Farach-Carson, J Rubin |
2005 | |
Short-Term Zoledronic Acid Treatment Increases Bone Mineral Density and Marrow Clonogenic Fibroblast Progenitors after Allogeneic Stem Cell Transplantation
L Tauchmanovà, P Ricci, B Serio, G Lombardi, A Colao, B Rotoli, C Selleri |
The Journal of clinical endocrinology and metabolism | 2005 |
Kieferknochennekrosen als mögliche unerwünschte Wirkung von Bisphosphonaten
S Hoefert, H Eufinger |
Mund- Kiefer- und Gesichtschirurgie | 2005 |
A crucial role of Caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
Masako Miura, Xiao-Dong Chen, Matthew R. Allen, Yanming Bi, Stan Gronthos, Byoung-Moo Seo, Saquib Lakhani, Richard A. Flavell, Xin-Hua Feng, Pamela Gehron Robey, Marian Young, Songtao Shi |
Journal of Clinical Investigation | 2004 |
Bisphosphonates: Environmental protection for the joint?
SR Goldring, EM Gravallese |
Arthritis & Rheumatism | 2004 |
Drugs Used to Treat Osteoporosis: The Critical Need for a Uniform Nomenclature Based on Their Action on Bone Remodeling
BL Riggs, AM Parfitt |
Journal of Bone and Mineral Research | 2004 |
Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells
F Journe, C Chaboteaux, JC Dumon, G Leclercq, G Laurent, JJ Body |
British Journal of Cancer | 2004 |
Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: A different perspective on the HRT dilemma
SC Manolagas, S Kousteni, JR Chen, M Schuller, L Plotkin, T Bellido |
Kidney International | 2004 |
Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes
S Boonen, P Haentjens, L Vandenput, D Vanderschueren |
Journal of Internal Medicine | 2004 |
Bone safety of long-term bisphosphonate treatment
G Rodan, A Reszka, E Golub, R Rizzoli |
Current Medical Research and Opinion | 2004 |
Osteoblast proliferation and maturation by bisphosphonates
GI Im, SA Qureshi, J Kenney, HE Rubash, AS Shanbhag |
Biomaterials | 2004 |
Long-term effects of neridronate on human osteoblastic cell cultures
B Frediani, A Spreafico, C Capperucci, F Chellini, D Gambera, P Ferrata, F Baldi, P Falsetti, A Santucci, L Bocchi, R Marcolongo |
Bone | 2004 |
Calcitonin Therapy in Osteoporosis
M Mu??oz-Torres, G Alonso, PM Raya |
Treatments in Endocrinology | 2004 |
Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
M Chaplet, C Detry, C Deroanne, LW Fisher, V Castronovo, A Bellahcéne |
Biochemical Journal | 2004 |
The efficacy of acute administration of pamidronate on the conservation of bone mass following severe burn injury in children: a double-blind, randomized, controlled study
GL Klein, SJ Wimalawansa, G Kulkarni, DJ Sherrard, AP Sanford, DN Herndon |
Osteoporosis International | 2004 |
Matrix Metalloproteinases (MMPs) Safeguard Osteoblasts from Apoptosis during Transdifferentiation into Osteocytes: MT1-MMP Maintains Osteocyte Viability
MA Karsdal, TA Andersen, L Bonewald, C Christiansen |
DNA and Cell Biology | 2004 |
Periosteum: biology, regulation, and response to osteoporosis therapies
MR Allen, JM Hock, DB Burr |
Bone | 2004 |
Calcitonin Receptor Gene and Breast Cancer: Quantitative Analysis with Laser Capture Microdissection
X Wang, M Nakamura, I Mori, K Takeda, Y Nakamura, H Utsunomiya, G Yoshimura, T Sakurai, K Kakudo |
Breast Cancer Research and Treatment | 2004 |
Selective in vitro antioxidant properties of bisphosphonates
EJ Dombrecht, P Cos, DV Berghe, JF Offel, AJ Schuerwegh, CH Bridts, WJ Stevens, LS Clerck |
Biochemical and Biophysical Research Communications | 2004 |
Bioprocess-centered molecular design (BMD) for the efficient production of an interfacially active peptide
G Morreale, EG Lee, DB Jones, AP Middelberg |
Biotechnology and Bioengineering | 2004 |
Systemic and local ibandronate enhance screw fixation
B Skoglund, J Holmertz, P Aspenberg |
Journal of Orthopaedic Research | 2004 |
Intravenous bisphosphonate therapy for osteoporosis: Where do we stand?
HG Bone, W Schurr |
Current Osteoporosis Reports | 2004 |
The treatment of glucocorticoid-induced osteoporosis
D Cohen, JD Adachi |
The Journal of Steroid Biochemistry and Molecular Biology | 2004 |
Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis
G Kogianni, V Mann, F Ebetino, M Nuttall, P Nijweide, H Simpson, B Noble |
Life Sciences | 2004 |
Osteoarthritis and osteoporosis in postmenopausal women: clinical similarities and differences
D Avci, GA Bachmann |
Menopause | 2004 |
Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis
KS Kim, YH Choi, KH Kim, YC Lee, CH Kim, SH Moon, SG Kang, YG Park |
International Immunopharmacology | 2004 |
Postmenopausal osteoporosis and alendronate
FR Pérez-López |
Maturitas | 2004 |
Effect of D-003, a Mixture of Very High Molecular Weight Aliphatic Acids, on Prednisolone-Induced Osteoporosis in Sprague-Dawley Rats:
M Noa, S Mendoza, R M??s, N Mendoza, F Le??n |
Drugs in R & D | 2004 |
Effect of pamidronate on new vertebral fractures and bone mineral density in patients with malignant lymphoma receiving chemotherapy
SH Kim, SK Lim, JS Hahn |
The American Journal of Medicine | 2004 |
Principles of Gender-Specific Medicine
G Supinski, LA Callahan |
Principles of Gender-Specific Medicine | 2004 |
The effect of alendronate on resorption of the alveolar bone following tooth extraction
H Altundal, Ö Güvener |
International Journal of Oral and Maxillofacial Surgery | 2004 |
Transient Versus Sustained Phosphorylation and Nuclear Accumulation of ERKs Underlie Anti- Versus Pro-apoptotic Effects of Estrogens
JR Chen, LI Plotkin, JI Aguirre, L Han, RL Jilka, S Kousteni, T Bellido, SC Manolagas |
The Journal of biological chemistry | 2004 |
The Skeleton
EJ Massaro, JM Rogers |
2004 | |
Nutrition and Bone Health
MF Holick, B Dawson-Hughes |
2004 | |
Effects of 1α,25-Dihydroxyvitamin D3 and Growth Hormone on Apoptosis and Proliferation in UMR 106 Osteoblast-Like Cells
O Morales, MK Samuelsson, U Lindgren, LA Haldosén |
Endocrinology | 2004 |
CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4
SS Ahuja, S Zhao, T Bellido, LI Plotkin, F Jimenez, LF Bonewald |
Endocrinology | 2003 |
Osteoclastogenesis, Bone Resorption, and Osteoclast-Based Therapeutics
M Zaidi, HC Blair, BS Moonga, E Abe, CL Huang |
Journal of Bone and Mineral Research | 2003 |
Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
X Zhang, D Carpenter, N Bokui, C Soo, S Miao, T Truong, B WU, I Chen, H Vastardis, K Tanizawa, SI Kuroda, K Ting |
Journal of Bone and Mineral Research | 2003 |
Perspectives on osteoporosis in pediatric inflammatory bowel disease
M Harpavat, DJ Keljo |
Current Gastroenterology Reports | 2003 |
Effect of pamidronate on the stimulation of macrophage TNF-α release by ultra-high-molecular-weight polyethylene particles: a role for apoptosis
OL Huk, DJ Zukor, J Antoniou, A Petit |
Journal of Orthopaedic Research | 2003 |
Understanding osteoclast formation and function: implications for future therapies for osteoporosis
M Zaidi, BS Moonga, L Sun, S Epstein, CL Huang, E Abe |
Current Opinion in Orthopaedics | 2003 |
Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survival
O Fromigue, N Kheddoumi, JJ Body |
British Journal of Cancer | 2003 |
Bisphosphonate Induced Growth Inhibition of Breast Cancer Cells is Augmented by p38 Inhibition
M Merrell, C Suarez-Cuervo, KW Harris, HK Väänänen, KS Selander |
Breast Cancer Research and Treatment | 2003 |
RANK-Fc: A therapeutic antagonist for RANK-L in myeloma
EM Sordillo, RN Pearse |
Cancer | 2003 |
Apoptosis: an introduction for the endodontist
PG Satchell, JL Gutmann, DE Witherspoon |
International Endodontic Journal | 2003 |
Prevention of Glucocorticoid-Induced Apoptosis in Osteocytes and Osteoblasts by Calbindin-D28k
Y Liu, A Porta, X Peng, K Gengaro, EB Cunningham, H Li, LA Dominguez, T Bellido, S Christakos |
Journal of Bone and Mineral Research | 2003 |
Osteocyte biology
LF Bonewald |
Current Opinion in Orthopaedics | 2003 |
Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures
F Itoh, S Aoyagi, H Furihata-Komatsu, M Aoki, H Kusama, M Kojima, H Kogo |
European Journal of Pharmacology | 2003 |
Inhibition of osteoblast apoptosis by thrombin
CN Pagel, MR de Niese, LA Abraham, C Chinni, SJ Song, RN Pike, EJ Mackie |
Bone | 2003 |
Bilateral Femoral Head Osteonecrosis After Septic Shock and Multiorgan Failure
MJ Bolland, G Hood, ST Bastin, AR King, A Grey |
Journal of Bone and Mineral Research | 2003 |
Determinants of Bone Strength
GM Kiebzak, PD Miller |
Journal of Bone and Mineral Research | 2003 |
Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and β2-microglobulin in multiple myeloma
E Terpos, N Viniou, J la Fuente, J Meletis, E Voskaridou, C Karkantaris, G Vaiopoulos, J Palermos, X Yataganas, JM Goldman, A Rahemtulla |
European Journal of Haematology | 2003 |
Biochemical markers of bone metabolism in bone marrow edema syndrome of the hip
CE Berger, AH Kröner, MB Minai-Pour, E Ogris, A Engel |
Bone | 2003 |
Prevention and Treatment of Glucocorticoid-Induced Osteoporosis: A Comparison of Calcitriol, Vitamin D Plus Calcium, and Alendronate Plus Calcium
PN Sambrook, M Kotowicz, P Nash, CB Styles, V Naganathan, KN Henderson-Briffa, JA Eisman, GC Nicholson |
Journal of Bone and Mineral Research | 2003 |
A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK
S Nishida, Y Fujii, S Yoshioka, S Kikuichi, M Tsubaki, K Irimajiri |
Life Sciences | 2003 |
Biology of the basic multicellular unit and the pathophysiology of osteoporosis
RL Jilka |
Medical and Pediatric Oncology | 2003 |
Glucocorticoid-induced osteoporosis: pathophysiological data and recent treatments
MH Lafage-Proust, B Boudignon, T Thomas |
Joint Bone Spine | 2003 |
Prévention et traitement de l’ostéoporose cortisonique
C Roux, P Orcel |
La Revue de Médecine Interne | 2003 |
Understanding osteoclast formation and function: implications for future therapies for osteoporosis:
M Zaidi, BS Moonga, L Sun, S Epstein, CL Huang, E Abe |
Current Opinion in Orthopaedics | 2003 |
La calcitonina hoy
HR Lenza |
Revista Clínica Española | 2003 |
Ostéoporose cortico-induite : données physiopathologiques et thérapeutiques récentes
MH Lafage-Proust, B Boudignon, T Thomas |
Revue du Rhumatisme | 2003 |
Calcitonin in the Treatment of Transient Osteoporosis of the Hip
TK Arayssi, HA Tawbi, IM Usta, MH Hourani |
Seminars in Arthritis and Rheumatism | 2003 |
Incadronate Amplifies Prostaglandin F 2α -induced Vascular Endothelial Growth Factor Synthesis in Osteoblasts: ENHANCEMENT OF MAPK ACTIVITY
H Tokuda, A Harada, K Hirade, H Matsuno, H Ito, K Kato, Y Oiso, O Kozawa |
The Journal of biological chemistry | 2003 |
Beyond the gap: functions of unpaired connexon channels
DA Goodenough, DL Paul |
Nature Reviews Molecular Cell Biology | 2003 |
Inflammatory Bowel Disease: From Bench to Bedside
SR Targan, F Shanahan, LC Karp |
2003 | |
Handbook of Histology Methods for Bone and Cartilage
YH An, KL Martin |
2003 | |
Promotion of Osteoclast Survival and Antagonism of Bisphosphonate-Induced Osteoclast Apoptosis by Glucocorticoids
Robert S. Weinstein, Jin-Ran Chen, Cara C. Powers, Reid D. Landes, Robert L. Jilka, A. Michael Parfitt, Stavros C. Manolagas |
Journal of Clinical Investigation | 2002 |
Age-Related Osteoporosis in Biglycan-Deficient Mice Is Related to Defects in Bone Marrow Stromal Cells
XD Chen, S Shi, T Xu, PG Robey, MF Young |
Journal of Bone and Mineral Research | 2002 |
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue
GG Reinholz, B Getz, ES Sanders, MY Karpeisky, NS Padyukova, SN Mikhailov, JN Ingle, TC Spelsberg |
Breast Cancer Research and Treatment | 2002 |
In vitro effects of combination chemotherapy on osteoblasts: implications for osteopenia in childhood malignancy
JH Davies, BA Evans, ME Jenney, JW Gregory |
Bone | 2002 |
Different effects of antiresorptive therapies on vertebral and nonvertebral fractures in postmenopausal osteoporosis
PD Delmas |
Bone | 2002 |
Spatial Distribution of Bax and Bcl-2 in Osteocytes After Bone Fatigue: Complementary Roles in Bone Remodeling Regulation?
O Verborgt, NA Tatton, RJ Majeska, MB Schaffler |
Journal of Bone and Mineral Research | 2002 |
Calcitonin: The Other Thyroid Hormone
AM Inzerillo, M Zaidi, CL Huang |
Thyroid | 2002 |
Noninvasive loading of the murine tibia: an in vivo model for the study of mechanotransduction
TS Gross, S Srinivasan, CC Liu, TL Clemens, SD Bain |
Journal of Bone and Mineral Research | 2002 |
Insulin secretion and sensitivity in space flight
BW Tobin, PN Uchakin, SK Leeper-Woodford |
Nutrition | 2002 |
Bisphosphonates Pamidronate and Zoledronic Acid Stimulate Osteoprotegerin Production by Primary Human Osteoblasts
V Viereck, G Emons, V Lauck, KH Frosch, S Blaschke, C Gründker, LC Hofbauer |
Biochemical and Biophysical Research Communications | 2002 |
MLO-Y4 Osteocyte-Like Cells Support Osteoclast Formation and Activation
S Zhao, Y Kato, Y Zhang, S Harris, SS Ahuja, LF Bonewald |
Journal of Bone and Mineral Research | 2002 |
Effects of a single infusion of pamidronate prior to liver transplantation: a bone histomorphometric study
S Vedi, M Ninkovic, NJ Garrahan, GJ Alexander, JE Compston |
Transplant International | 2002 |
Prevention of Bone Loss in Ovariectomized Rats by Combined Treatment With Risedronate and 1α,25-Dihydroxyvitamin D3
RG Erben, L Mosekilde, JS Thomsen, K Weber, K Stahr, A Leyshon, SY Smith, R Phipps |
Journal of Bone and Mineral Research | 2002 |
Pharmacotherapy of osteoporosis
M KOIDA |
Folia Pharmacologica Japonica | 2002 |
Intravenous pamidronate in the treatment of transient osteoporosis of the hip
M Varenna, F Zucchi, L Binelli, S Failoni, M Gallazzi, L Sinigaglia |
Bone | 2002 |
Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density
IR Reid, JP Brown, P Burckhardt, Z Horowitz, P Richardson, U Trechsel, A Widmer, JP Devogelaer, JM Kaufman, P Jaeger, JJ Body, ML Brandi, J Broell, RD Micco, AR Genazzani, D Felsenberg, J Happ, MJ Hooper, J Ittner, G Leb, H Mallmin, T Murray, S Ortolani, A Rubinacci, M Sääf, G Samsioe, L Verbruggen, PJ Meunier |
New England Journal of Medicine | 2002 |
Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-?: Enhancement by estrogen
TJ Heino, TA Hentunen, HK V��n�nen |
Journal of Cellular Biochemistry | 2002 |
Alendronate Treatment for Infants with Osteogenesis Imperfecta: Demonstration of Efficacy in a Mouse Model
EA McCarthy, CL Raggio, MD Hossack, EA Miller, S Jain, AL Boskey, NP Camacho |
Pediatric Research | 2002 |
Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS
M Zaidi, AM Inzerillo, BS Moonga, PJ Bevis, CL Huang |
Bone | 2002 |
Traitement médicamenteux des ostéoporoses post-ménopausiques et cortisoniques
C Roux |
Revue du Rhumatisme | 2002 |
Alendronate increases bone mineral density in long-term renal transplant recipients
M Koc, S Tuglular, H Arikan, C Ozener, E Akoglu |
Transplantation Proceedings | 2002 |
Histomorphometric Analysis of Bone Biopsies from the Iliac Crest of Adults with Cystic Fibrosis
SL Elkin, S Vedi, S Bord, NJ Garrahan, ME Hodson, JE Compston |
American journal of respiratory and critical care medicine | 2002 |
Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts
O Fromigué, JJ Body |
Journal of Endocrinological Investigation | 2002 |
Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis
MA Karsdal, L Larsen, MT Engsig, H Lou, M Ferreras, A Lochter, JM Delaissé, NT Foged |
The Journal of biological chemistry | 2002 |
Recent Advances in Glucocorticoid Receptor Action
AC Cato, H Schäcke, K Asadullah |
2002 | |
Statins as modulators of bone formation
CJ Edwards, TD Spector |
Arthritis Research & Therapy | 2002 |
Genetic Approaches to Determine the Role of Glucocorticoid Signaling in Osteoblasts
JR Harrison, HW Woitge, BE Kream |
Endocrine | 2002 |
Glucocorticoid-induced osteoporosis
R Kumar |
Current Opinion in Nephrology and Hypertension | 2001 |
Transplantation osteoporosis
A Cohen, E Shane |
Current Opinion in Endocrinology & Diabetes | 2001 |
Bisphosphonates: mechanisms of action
H Fleisch |
Expert Opinion on Therapeutic Patents | 2001 |
Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43
LI Plotkin, T Bellido |
Cell Communication and Adhesion | 2001 |
Perspective: Reconsidering the Effects of Antiresorptive Therapies in Reducing Osteoporotic Fracture
CH Chesnut, CJ Rosen |
Journal of Bone and Mineral Research | 2001 |
Extracellular Signal-Regulated Kinases and Calcium Channels Are Involved in the Proliferative Effect of Bisphosphonates on Osteoblastic Cells In Vitro
I Mathov, LI Plotkin, CL Sgarlata, J Leoni, T Bellido |
Journal of Bone and Mineral Research | 2001 |
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
S Kousteni, T Bellido, LI Plotkin, CA O'Brien, DL Bodenner, L Han, K Han, GB DiGregorio, JA Katzenellenbogen, BS Katzenellenbogen, PK Roberson, RS Weinstein, RL Jilka, SC Manolagas |
Cell | 2001 |
Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
PS Mackie, JL Fisher, H Zhou, PF Choong |
British Journal of Cancer | 2001 |
Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism
K Mansfield, CC Teixeira, CS Adams, IM Shapiro |
Bone | 2001 |
Incadronate and Etidronate Accelerate Phosphate-Primed Mineralization of MC4 Cells via ERK1/2-Cbfal Signaling Pathway in a Ras-Independent Manner: Further Involvement of Mevalonate-Pathway Blocade for Incadronate
T Fujita, N Izumo, R Fukuyama, T Meguro, C Yasutomi, H Nakamuta, M Koida |
The Japanese Journal of Pharmacology | 2001 |
The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro
J Sonnemann, V Eckervogt, B Truckenbrod, J Boos, W Winkelmann, F Valen |
Anti-Cancer Drugs | 2001 |
Apoptosis may determine the release of skeletal alkaline phosphatase activity from human osteoblast-line cells
JR Farley, B Stilt-Coffing |
Calcified Tissue International | 2001 |
Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment
E Terpos, J Palermos, N Viniou, G Vaiopoulos, J Meletis, X Yataganas |
Calcified Tissue International | 2001 |
Abnormal bone turnover in long-standing Crohn's disease in remission
EJ Schoon, BG Geerling, IM van Dooren, LJ Schurgers, C Vermeer, RJ Brummer, RW Stockbrugger |
Alimentary Pharmacology & Therapeutics | 2001 |
Can Bisphosphonates Be Given to Patients with Fractures?
H Fleisch |
Journal of Bone and Mineral Research | 2001 |
How do antiresorptive agents reduce fracture risk?
E Seeman |
BoneKEy-Osteovision | 2001 |
Problèmes méthodologiques de la mesure de densité osseuse par absorptiométrie biphotonique
C Roux, M Dougados |
ITBM-RBM | 2001 |
La situación actual de la utilización de la calcitonina en la osteopenia/osteoporosis
FH Carranza |
Revista Clínica Española | 2001 |
Manipulating Programmed Cell Death for Better Living!
SC Manolagas |
Science signaling | 2001 |
Effect of 17ß-estradiol or alendronate on the bone densitometry, bone histomorphometry and bone metabolism of ovariectomized rats
LH Paz, V Falco, NC Teng, LM Reis, RM Pereira, V Jorgetti |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2001 |
TREATMENT OF ESTABLISHED BONE LOSS AFTER RENAL TRANSPLANTATION WITH ETIDRONATE1:
DJ Arlen, K Lambert, G Ioannidis, JD Adachi |
Transplantation | 2001 |
Glucocorticoid-induced osteoporosis
R S Weinstein |
Reviews in Endocrine and Metabolic Disorders | 2001 |
Prolonged, Symptomatic Hypocalcemia with Pamidronate Administration and Subclinical Hypoparathyroidism
A Mishra, L Wong, J Jonklaas |
Endocrine | 2001 |
Alendronate Stimulates Collagenase 3 Expression in Osteoblasts by Posttranscriptional Mechanisms
S Varghese, E Canalis |
Journal of Bone and Mineral Research | 2000 |
True Strength
RS Weinstein |
Journal of Bone and Mineral Research | 2000 |
Osteogenesis Imperfecta
F Antoniazzi, M Mottes, P Fraschini, PC Brunelli, L Tat?? |
Paediatric Drugs | 2000 |
Therapeutic patenting for glucocorticoid-induced osteoporosis
MS Cooper, PM Stewart |
Expert Opinion on Therapeutic Patents | 2000 |
Corticosteroids and Fractures: A Close Encounter of the Third Cell Kind
SC Manolagas |
Journal of Bone and Mineral Research | 2000 |
Apoptosis and osteoporosis
RS Weinstein, SC Manolagas |
The American Journal of Medicine | 2000 |
Etidronate inhibits human osteoblast apoptosis by inhibition of pro-apoptotic factor(s) produced by activated T cells
Y Abe, A Kawakami, T Nakashima, E Ejima, K Fujiyama, T Kiriyama, A Ide, N Sera, T Usa, T Tominaga, K Ashizawa, N Yokoyama, K Eguchi |
The Journal of laboratory and clinical medicine | 2000 |
Statins: lower lipids and better bones?
MJ Rogers |
Nature Medicine | 2000 |
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1
SC Manolagas |
Endocrine reviews | 2000 |
Calbindin-D 28k Is Expressed in Osteoblastic Cells and Suppresses Their Apoptosis by Inhibiting Caspase-3 Activity
T Bellido, M Huening, M Raval-Pandya, SC Manolagas, S Christakos |
The Journal of biological chemistry | 2000 |
Bisphosphonates prevent osteocyte apoptosis
M Rogers |
Arthritis Research & Therapy | 1999 |
Corticosteroid-Induced Osteoporosis
JD Adachi |
The American Journal of the Medical Sciences | 1997 |
Osteoporosis
DL Glaser, FS Kaplan |
Spine | 1997 |
Rheumatology
RA Asherson, R Cervera, DP D'Cruz, GR Hughes |
Postgraduate medical journal | 1991 |