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Citations to this article

AMPK, insulin resistance, and the metabolic syndrome
Neil B. Ruderman, … , Marc Prentki, José M. Cacicedo
Neil B. Ruderman, … , Marc Prentki, José M. Cacicedo
Published July 1, 2013
Citation Information: J Clin Invest. 2013;123(7):2764-2772. https://doi.org/10.1172/JCI67227.
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AMPK, insulin resistance, and the metabolic syndrome

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Abstract

Insulin resistance (IR) and hyperinsulinemia are hallmarks of the metabolic syndrome, as are central adiposity, dyslipidemia, and a predisposition to type 2 diabetes, atherosclerotic cardiovascular disease, hypertension, and certain cancers. Regular exercise and calorie restriction have long been known to increase insulin sensitivity and decrease the prevalence of these disorders. The subsequent identification of AMP-activated protein kinase (AMPK) and its activation by exercise and fuel deprivation have led to studies of the effects of AMPK on both IR and metabolic syndrome–related diseases. In this review, we evaluate this body of literature, with special emphasis on the hypothesis that dysregulation of AMPK is both a pathogenic factor for these disorders in humans and a target for their prevention and therapy.

Authors

Neil B. Ruderman, David Carling, Marc Prentki, José M. Cacicedo

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T Vezza, J Garrido-Mesa, P Diez-Echave, L Hidalgo-García, AJ Ruiz-Malagón, F García, M Sánchez, M Toral, M Romero, J Duarte, E Guillamón, AB Arjona, R Moron, J Galvez, A Rodríguez-Nogales, ME Rodríguez-Cabezas
Nutrients 2021
A spotlight on underlying the mechanism of AMPK in diabetes complications
T Behl, A Gupta, A Sehgal, S Sharma, S Singh, N Sharma, CC Diaconu, A Rahdar, A Hafeez, S Bhatia, A Al-Harrasi, S Bungau
Inflammation Research 2021
Lipid Extract From a Vegetable (Sonchus Oleraceus) Attenuates Adipogenesis and High Fat Diet-Induced Obesity Associated With AMPK Activation
CY Chen, CW Su, X Li, Y Liu, Q Pan, T Cao, JX Kang
Frontiers in Nutrition 2021
Adipose-specific C-C motif chemokine ligand (CCL) 19 overexpression drives the mice to both insulin resistance and weight gain
M Hayashi, M Iwashita, Y Nishimura, T Shinjo, T Sano, A Yamashita, T Fukuda, T Sanui, T Asano, F Nishimura
BMJ Open Diabetes Research & Care 2021
The Current and Potential Therapeutic Use of Metformin—The Good Old Drug
J Drzewoski, M Hanefeld
Pharmaceuticals (Basel, Switzerland) 2021
The emerging relationship between metabolism and DNA repair
D Cucchi, A Gibson, S a Martin
Cell cycle (Georgetown, Tex.) 2021
Nicotine, smoking, podocytes, and diabetic nephropathy
EA Jaimes, MS Zhou, M Siddiqui, G Rezonzew, R Tian, SV Seshan, AN Muwonge, NJ Wong, EU Azeloglu, A Fornoni, S Merscher, L Raij
American journal of physiology. Renal physiology 2021
Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms
A Nani, B Murtaza, AS Khan, NA Khan, A Hichami
Molecules (Basel, Switzerland) 2021
Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis
P GluaisDagorn, M Foretz, GR Steinberg, B Batchuluun, A ZawistowskaDeniziak, JM Lambooij, B Guigas, D Carling, PA Monternier, DE Moller, S Bolze, S HallakouBozec
Hepatology Communications 2021
The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease
E Barone, FD Domenico, M Perluigi, DA Butterfield
Free radical biology & medicine 2021
The Link Between Periodontal Inflammation and Obesity
M Iwashita, M Hayashi, Y Nishimura, A Yamashita
Current Oral Health Reports 2021
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK
R Bao, Y Meng, H Zhang, C Yang, W Li, C Zhang, J Zhang, R Sun, Z Li, W Jiang, C Zhang, C Zhang, HX Yuan, Y Dang
Cell Death and Disease 2021
The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model
M Maldonado, J Chen, Y Lujun, H Duan, MA Raja, T Qu, T Huang, J Gu, Y Zhong
Aging 2021
The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance
D Aguilar-Recarte, X Palomer, W Wahli, M Vázquez-Carrera
International journal of molecular sciences 2021
Antidiabetic Flavonoids from Fruits of Morus alba Promoting Insulin-Stimulated Glucose Uptake via Akt and AMP-Activated Protein Kinase Activation in 3T3-L1 Adipocytes
SH Lim, JS Yu, HS Lee, CI Choi, KH Kim
Pharmaceutics 2021
Downregulated hypoxia-inducible factor 1α improves myoblast differentiation under hypoxic condition in mouse genioglossus
Y Lu, J Mao, X Han, W Zhang, Y Li, Y Liu, Q Li
Molecular and Cellular Biochemistry 2021
Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization
K Tokuda, Y Yamanaka, Y Mano, M Tsukamoto, T Tajima, H Suzuki, M Kawasaki, S Uchida, E Nakamura, KY Wang, A Sakai
Scientific Reports 2021
The Impact of Metformin Use with Survival Outcomes in Urologic Cancers: A Systematic Review and Meta-Analysis
X Yao, H Liu, H Xu, X Duan
BioMed Research International 2021
WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1
Z Zheng, Y Li, S Fan, J An, , M Liang, F Zhu, K Huang
Cell Death and Disease 2021
Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
V Frisardi, C Matrone, ME Street
Frontiers in Cell and Developmental Biology 2021
Targeting MMP-Regulation of Inflammation to Increase Metabolic Tolerance to COVID-19 Pathologies: A Hypothesis
E Hardy, C Fernandez-Patron
Biomolecules 2021
IQGAP1 binds AMPK and is required for maximum AMPK activation
AC Hedman, Z Li, L Gorisse, S Parvathaneni, CJ Morgan, DB Sacks
The Journal of biological chemistry 2021
Dietary Control of Inflammation and Resolution
B Sears, AK Saha
Frontiers in Nutrition 2021
Imatinib improves insulin resistance and inhibits injury-induced neointimal hyperplasia in high fat diet-fed mice
P Pichavaram, NM Shawky, TJ Hartney, JY Jun, L Segar
European Journal of Pharmacology 2021
Plasma Metabolome and Lipidome Associations with Type 2 Diabetes and Diabetic Nephropathy
YM Tan, Y Gao, G Teo, HW Koh, ES Tai, CM Khoo, KP Choi, L Zhou, H Choi
Metabolites 2021
p-Coumaric Acid Enhances Hypothalamic Leptin Signaling and Glucose Homeostasis in Mice via Differential Effects on AMPK Activation
LV Nguyen, KD Nguyen, CT Ma, QT Nguyen, HT Nguyen, DJ Yang, TL Tran, KW Kim, KV Doan
International journal of molecular sciences 2021
CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys
Y Hou, Q Wang, B Han, Y Chen, , L Wang
Cell Death and Disease 2021
MicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome
G Liu, Y Lei, S Luo, Z Huang, C Chen, K Wang, P Yang, X Huang
Bioengineered 2021
Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis
ME Youssef, EE El-Fattah, AM Abdelhamid, H Eissa, E El-Ahwany, NA Amin, HF Hetta, MH Mahmoud, GE Batiha, N Gobba, AG Gaafar, S Saber
Frontiers in pharmacology 2021
DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases
FZ Khoubai, CF Grosset
International journal of molecular sciences 2021
Oxidant/antioxidant status in Type-2 diabetes mellitus patients with metabolic syndrome
A Najafi, M Pourfarzam, F Zadhoush
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 2021
Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease
P Prasun, I Ginevic, K Oishi
Translational Gastroenterology and Hepatology 2021
Metabolic syndrome among individuals living with hypertension in Accra, Ghana
AK Christian, OA Sanuade, SB Kushitor, M Kushitor, I Kretchy, C Agyemang, A de-Graft Aikins, G Musinguzi
PloS one 2021
Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK
JZ ALTamimi, GM Alshammari, NA AlFaris, RI Alagal, DH Aljabryn, NA Albekairi, MA Alkhateeb, MA Yahya
Pharmaceutical Biology 2021
Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin
PG Tremblay, C Fortin, MA Sirard
Journal of Ovarian Research 2021
Ameliorating Metabolic Profiles After Kidney Transplantation: A Protocol for an Open-Label, Prospective, Randomized, 3-Arm, Controlled Trial
S Yin, M Ma, Z Huang, Y Fan, X Wang, T Song, T Lin
Frontiers in Medicine 2021
Transcriptome and metabolome changes induced by bitter melon (Momordica charantia)- intake in a high-fat diet induced obesity model
D Reed, D Kumar, S Kumar, K Raina, R Punia, R Kant, L Saba, C Cruickshank-Quinn, B Tabakoff, N Reisdorph, M Edwards, M Wempe, C Agarwal, R Agarwal
Journal of traditional and complementary medicine 2021
Clerodendrum trichotomum extract improves metabolic derangements in high fructose diet-fed rats
Jang MG, Oh JM, Ko HC, Kim JW, Baek S, Jin YJ, Hur SP, Kim SJ
Animal Cells and Systems 2021
Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome
Alesi S, Ee C, Moran LJ, Rao V, Mousa A
Advances in Nutrition 2021
PRKAA2 variation and the clinical characteristics of patients newly diagnosed with type 2 diabetes mellitus in Yogyakarta, Indonesia
Virginia DM, Wahyuningsih MS, Nugrahaningsih DA
2021
Demystifying pulmonary fibrosis
G Jenkins
American journal of physiology. Lung cellular and molecular physiology 2020
Icariin enhances AMP-activated protein kinase and prevents high fructose and high salt-induced metabolic syndrome in rats
AA Aljehani, NA Albadr, BG Eid, AB Abdel-Naim
Saudi Pharmaceutical Journal 2020
Activation of AMP-activated protein kinase signaling pathway ameliorates steatosis in laying hen hepatocytes
K Zhang, Y Shi, C Huang, C Huang, P Xu, C Zhou, P Liu, R Hu, Y Zhuang, G Li, G Hu, X Guo
Poultry science 2020
COVID-19 and diabetes mellitus: how one pandemic worsens the other
WS Azar, R Njeim, AH Fares, NS Azar, ST Azar, ME Sayed, AA Eid
Reviews in Endocrine and Metabolic Disorders 2020
Ginsenoside compound-Mc1 attenuates oxidative stress and apoptosis in cardiomyocytes through an AMP-activated protein kinase–dependent mechanism
S Hong, HJ Hwang, JW Kim, JA Kim, YB Lee, E Roh, KM Choi, SH Baik, HJ Yoo
Journal of Ginseng Research 2020
The Influence of Physical Activity on the Bioactive Lipids Metabolism in Obesity-Induced Muscle Insulin Resistance
M Imierska, A Kurianiuk, A Błachnio-Zabielska
Biomolecules 2020
Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
NJ Hoffman, J Whitfield, NR Janzen, MR Belhaj, S Galic, L Murray-Segal, WJ Smiles, NX Ling, TA Dite, JW Scott, JS Oakhill, R Brink, BE Kemp, JA Hawley
Molecular Metabolism 2020
Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents
C Huet, N Boudaba, B Guigas, B Viollet, M Foretz
The Journal of biological chemistry 2020
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
S Mukherjee, J Haubner, A Chakraborty
Molecules (Basel, Switzerland) 2020
Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells
T Zhang, X Qin, Y Cao, J Zhang, J Zhao
Food Science and Biotechnology 2020
AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
AM Evans, DG Hardie
International journal of molecular sciences 2020
Beneficial effects of green coffee and green tea extract combination on metabolic syndrome improvement by affecting AMPK And PPAR-α gene expression
M Lukitasari, DA Nugroho, MS Rohman, N Widodo, A Farmawati, P Hastuti
Journal of Advanced Pharmaceutical Technology & Research 2020
Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation
C Rodríguez, C Contreras, J Sáenz-Medina, M Muñoz, C Corbacho, J Carballido, A García-Sacristán, M Hernandez, M López, L Rivera, D Prieto
Redox Biology 2020
Salvianolate ameliorates oxidative stress and podocyte injury through modulation of NOX4 activity in db/db mice
Y Liang, H Liu, Y Fang, P Lin, Z Lu, P Zhang, X Jiao, J Teng, X Ding, Y Dai
Journal of Cellular and Molecular Medicine 2020
The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK
NM Morrow, AC Burke, JP Samsoondar, KE Seigel, A Wang, DE Telford, BG Sutherland, C ODwyer, GR Steinberg, MD Fullerton, MW Huff
Journal of lipid research 2020
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
B Li, M Zhang, Y Duan, L Shuai, H Jiang, J Li, F Nan, J Li
Acta Pharmacologica Sinica 2020
Exendin-4 Improves Diabetic Kidney Disease in C57BL/6 Mice Independent of Brown Adipose Tissue Activation
S Fang, Y Cai, F Lyu, H Zhang, C Wu, Y Zeng, C Fan, S Zou, Y Zhang, P Li, L Wang, YaomingXue, M Guan
Journal of Diabetes Research 2020
Crocin Improves Insulin Sensitivity and Ameliorates Adiposity by Regulating AMPK-CDK5-PPAR γ Signaling
K Fang, M Gu
BioMed Research International 2020
Correlation between 12α-hydroxylated bile acids and insulin secretion during glucose tolerance tests in rats fed a high-fat and high-sucrose diet
R Yoshitsugu, K Kikuchi, S Hori, H Iwaya, M Hagio, H Shimizu, T Hira, S Ishizuka
Lipids in Health and Disease 2020
Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis
DH Lee, SH Park, J Ahn, SP Hong, E Lee, YJ Jang, TY Ha, YH Huh, SY Ha, TI Jeon, CH Jung
Autophagy 2020
Association of handgrip strength with the prevalence of metabolic syndrome in US adults: the national health and nutrition examination survey
C Ji, Y Xia, S Tong, Q Wu, Y Zhao
Aging 2020
Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among the Chinese male population: two cohort studies
Y Liu, Z Du, J Ji, J Li, D Bi, F Tang
Lipids in Health and Disease 2020
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes
A Alex, Q Luo, D Mathew, R Di, AD Bhatwadekar
Investigative ophthalmology & visual science 2020
Ganoderma lucidum Extract Reduces Insulin Resistance by Enhancing AMPK Activation in High-Fat Diet-Induced Obese Mice
HA Lee, JH Cho, Q Afinanisa, GH An, JG Han, HJ Kang, SH Choi, HA Seong
Nutrients 2020
Effect of pioglitazone on skeletal muscle lipid deposition in the insulin resistance rat model induced by high fructose diet under AMPK signaling pathway
L Tan, A Song, L Ren, C Wang, G Song
Saudi Journal of Biological Sciences 2020
Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis
Z Cai, CF Li, F Han, C Liu, A Zhang, CC Hsu, D Peng, X Zhang, G Jin, AH Rezaeian, G Wang, W Zhang, BS Pan, CY Wang, YH Wang, SY Wu, SC Yang, FC Hsu, RB DAgostino, CM Furdui, GL Kucera, JS Parks, FH Chilton, CY Huang, FJ Tsai, B Pasche, K Watabe, HK Lin
Molecular Cell 2020
The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial
F Haidari, N Banaei-Jahromi, M Zakerkish, K Ahmadi
Nutrition Journal 2020
Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1α pathway in mice
Y Li, B Wang, J Shen, M Bai, E Xu
Pharmaceutical Biology 2020
Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
Y Shan, S Zhang, B Gao, S Liang, H Zhang, X Yu, J Zhao, L Ye, Q Yang, W Shang
Frontiers in pharmacology 2020
AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in drosophila
J Liu, X Wang, R Ma, T Li, G Guo, B Ning, TH Moran, WW Smith
Journal of cell science 2020
Brown Seaweeds for the Management of Metabolic Syndrome and Associated Diseases
D Gabbia, SD Martin
Molecules (Basel, Switzerland) 2020
Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK
MM Algandaby
Saudi Journal of Biological Sciences 2020
CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes
J Luo, Y Hou, M Xie, W Ma, D Shi, B Jiang
Marine drugs 2020
A Combination of Apple Vinegar Drink with Bacillus coagulans Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis
R Urtasun, J Díaz-Gómez, M Araña, MJ Pajares, M Oneca, P Torre, M Jiménez, G Munilla, M Barajas, I Encío
Nutrients 2020
Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation
T Li, J Liu, G Guo, B Ning, X Li, G Zhu, D Yang, TH Moran, WW Smith
International journal of molecular sciences 2020
New Amphiphilic Squalene Derivative Improves Metabolism of Adipocytes Differentiated From Diabetic Adipose-Derived Stem Cells and Prevents Excessive Lipogenesis
M Ganbold, F Ferdousi, T Arimura, K Tominaga, H Isoda
Frontiers in Cell and Developmental Biology 2020
Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-κB) Activation
Y Ming, Y Yin, Z Sun
Medical science monitor : international medical journal of experimental and clinical research 2020
AMPK-Targeted Effector Networks in Mycobacterial Infection
EK Jo, P Silwal, JM Yuk
Frontiers in microbiology 2019
AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases
Q Lu, X Li, J Liu, X Sun, T Rousselle, D Ren, N Tong, J Li
Bioscience Reports 2019
Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation
A Bort, B Sánchez, P Mateos-Gómez, I Díaz-Laviada, N Rodríguez-Henche
International journal of molecular sciences 2019
Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
ES Muise, HP Guan, J Liu, AR Nawrocki, X Yang, C Wang, CG Rodríguez, D Zhou, JN Gorski, MM Kurtz, D Feng, KJ Leavitt, L Wei, RR Wilkening, JM Apgar, S Xu, K Lu, W Feng, Y Li, H He, SF Previs, X Shen, M van Heek, SC Souza, MJ Rosenbach, T Biftu, MD Erion, DE Kelley, DM Kemp, RW Myers, IK Sebhat, L Bertrand
PloS one 2019
Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
J Moon, MJ Ha, MJ Shin, OY Kim, EH Yoo, J Song, JH Chung
Nutrients 2019
Isoquercetin regulates SREBP-1C via AMPK pathway in skeletal muscle to exert antihyperlipidemic and anti-inflammatory effects in STZ induced diabetic rats
M Jayachandran, T Zhang, Z Wu, Y Liu, B Xu
Molecular Biology Reports 2019
Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism
M Pelosse, C Cottet-Rousselle, CM Bidan, A Dupont, K Gupta, I Berger, U Schlattner
Nature Communications 2019
Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3
V Castrejón-Téllez, M Villegas-Romero, I Pérez-Torres, G Zarco, M Rubio-Ruiz, E Carreón-Torres, E Díaz-Díaz, O Grimaldo, V Guarner-Lans
Nutrients 2019
Obesity medications in development
CJ Rebello, FL Greenway
Expert Opinion on Investigational Drugs 2019
Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review
M Oses, JM Sanchez, MP Portillo, CM Aguilera, I Labayen
Nutrients 2019
Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais
K Suriyaprom, S Kaewprasert, P Putpadungwipon, P Namjuntra, S Klongthalay
Journal of Health, Population and Nutrition 2019
Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within
J Liu, Z Liu
International journal of molecular sciences 2019
WWOX somatic ablation in skeletal muscles alters glucose metabolism
M Abu-Remaileh, M Abu-Remaileh, R Akkawi, I Knani, S Udi, ME Pacold, J Tam, RI Aqeilan
Molecular Metabolism 2019
AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking
AF ODonnell, MC Schmidt
International journal of molecular sciences 2019
12,23-Dione dammarane triterpenes from Gynostemma longipes and their muscle cell proliferation activities via activation of the AMPK pathway
TK Ha, HT Pham, HM Cho, VO Tran, JL Yang, DW Jung, DR Williams, WK Oh
Scientific Reports 2019
Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat
Y Hong, Y Lin, Q Si, L Yang, W Dong, X Gu
Frontiers in Endocrinology 2019
Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway
Q Li, S Jia, L Xu, B Li, N Chen
Food Science & Nutrition 2019
Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK
HR Jin, CH Du, CZ Wang, CS Yuan, W Du
Cell Death and Disease 2019
The Role of AMP-Activated Protein Kinase as a Potential Target of Treatment of Hepatocellular Carcinoma
X Jiang, HY Tan, S Teng, YT Chan, D Wang, N Wang
Cancers 2019
PGC-1α protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway
Y Liu, J Zhai, J Chen, X Wang, T Wen
Human Cell 2019
Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK Activities: Potential Markers of Obesity-Related CV Risk
CF García-Prieto, M Gil-Ortega, E Vega-Martín, D Ramiro-Cortijo, M Martín-Ramos, E Bordiú, A Sanchez-Pernaute, A Torres, I Aránguez, M Fernández-Alfonso, MA Rubio, B Somoza
Frontiers in physiology 2019
Serum from Jiao-Tai-Wan treated rats increases glucose consumption by 3T3-L1 adipocytes through AMPK pathway signaling
L Yuan, P Tang, HJ Li, N Hu, XY Zhong, M Lin, YQ Sun, M Lu, X Lu
Bioscience Reports 2019
Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA‑treated HepG2 cells
Y Liu, L Liao, Y Chen, F Han
Molecular medicine reports 2019
Abelmoschus esculentus subfractions attenuate beta amyloid-induced neuron apoptosis by regulating DPP-4 with improving insulin resistance signals
CN Huang, CJ Wang, CL Lin, AT Yen, HH Li, CH Peng, F Gallyas
PloS one 2019
The historical context and scientific legacy of John O. Holloszy
JM Hagberg, EF Coyle, KM Baldwin, GD Cartee, L Fontana, MJ Joyner, JP Kirwan, DR Seals, EP Weiss
Journal of applied physiology 2019
Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway
N Kim, MS Kang, M Nam, SA Kim, GS Hwang, HS Kim
International journal of molecular sciences 2019
The relevance of AMP-activated protein kinase in insulin-secreting β cells: a potential target for improving β cell function?
T Szkudelski, K Szkudelska
Journal of Physiology and Biochemistry 2019
Consumption of lycopene-rich tomatoes improved glucose homeostasis in rats via an increase in leptin levels
N Hashimoto, N Tominaga, M Wakagi, Y Ishikawa-Takano
Journal of Natural Medicines 2019
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type2 diabetes patients
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrick Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist, Madelene Ericsson, Björn Eriksson, Kajsa Linde, Jacob Westman, Thomas Edlund, Helena Edlund
JCI Insight 2018
AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
N Boudaba, A Marion, C Huet, R Pierre, B Viollet, M Foretz
EBioMedicine 2018
AMPK in skeletal muscle function and metabolism
R Kjøbsted, JR Hingst, J Fentz, M Foretz, MN Sanz, C Pehmøller, M Shum, A Marette, R Mounier, JT Treebak, JF Wojtaszewski, B Viollet, L Lantier
The FASEB Journal 2018
Dai-Zong-Fang, A Traditional Chinese Herbal Formula, Ameliorates Insulin Resistance in db/db Mice
L Zhu, X Zhu, G Sun, X Meng, M Wang, H Cui, J Wang, Y Zhai, K Yang, Y Tang, X Sun, X Liu
Frontiers in physiology 2018
METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice
TW Jung, SH Lee, HC Kim, JS Bang, AM El-Aty, A Hacımüftüoğlu, YK Shin, JH Jeong
Experimental & molecular medicine 2018
The role of DNA-PK in aging and energy metabolism
JH Chung
The FEBS journal 2018
Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
MS Lee, HJ Han, SY Han, IY Kim, S Chae, CS Lee, SE Kim, SG Yoon, JW Park, JH Kim, S Shin, M Jeong, A Ko, HY Lee, KJ Oh, YH Lee, KH Bae, SH Koo, J Kim, JK Seong, D Hwang, J Song
Nature Communications 2018
Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
MF van Stee, AA de Graaf, AK Groen
Cardiovascular Diabetology 2018
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin
M Lee, M Katerelos, K Gleich, S Galic, BE Kemp, PF Mount, DA Power
Journal of the American Society of Nephrology : JASN 2018
Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes
A Burgeiro, AC Fonseca, D Espinoza, L Carvalho, N Lourenço, M Antunes, E Carvalho
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018
Scaffold Proteins: From Coordinating Signaling Pathways to Metabolic Regulation
Y Mugabo, GE Lim
Endocrinology 2018
Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK
N Morita, T Hosaka, A Kitahara, T Murashima, H Onuma, Y Sumitani, K Takahashi, T Tanaka, T Kondo, H Ishida
Journal of Diabetes Research 2018
A long-term mechanistic computational model of physiological factors driving the onset of type 2 diabetes in an individual
J Sarkar, G Dwivedi, Q Chen, IE Sheu, M Paich, CM Chelini, PM D'Alessandro, SP Burns, J DiStefano
PloS one 2018
Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue
K Ohki, H Wakui, N Kishio, K Azushima, K Uneda, S Haku, R Kobayashi, K Haruhara, S Kinguchi, T Yamaji, T Yamada, S Minegishi, T Ishigami, Y Toya, A Yamashita, K Imajo, A Nakajima, I Kato, K Ohashi, K Tamura
Scientific Reports 2018
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
JS Lally, S Ghoshal, DK DePeralta, O Moaven, L Wei, R Masia, DJ Erstad, N Fujiwara, V Leong, VP Houde, AE Anagnostopoulos, A Wang, LA Broadfield, RJ Ford, RA Foster, J Bates, H Sun, T Wang, H Liu, AS Ray, AK Saha, J Greenwood, S Bhat, G Harriman, W Miao, JL Rocnik, WF Westlin, P Muti, T Tsakiridis, HJ Harwood, R Kapeller, Y Hoshida, KK Tanabe, GR Steinberg, BC Fuchs
Cell Metabolism 2018
Hypothalamic AMPK and energy balance
M López
European Journal of Clinical Investigation 2018
L-Carnitine: An Antioxidant Remedy for the Survival of Cardiomyocytes under Hyperglycemic Condition
F Vacante, P Senesi, A Montesano, A Frigerio, L Luzi, I Terruzzi
Journal of Diabetes Research 2018
Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance
AN Onyango
Oxidative medicine and cellular longevity 2018
Pathophysiological significance of hepatokine overproduction in type 2 diabetes
H Misu
Diabetology International 2018
A novel SIRT1 activator E6155 improves insulin sensitivity in type 2 diabetic KKA y mice
P Liu, T Feng, X Zuo, X Wang, J Luo, N Li, X Han, N Zhu, S Xu, Y Xu, ZhengJin, S Si
Biochemical and Biophysical Research Communications 2018
Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress
N Veličković, A Teofilović, D Ilić, A Djordjevic, DV Milutinović, S Petrović, F Preitner, L Tappy, G Matić
European Journal of Nutrition 2018
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans
C Riedinger, M Mendler, A Schlotterer, T Fleming, J Okun, HP Hammes, S Herzig, PP Nawroth
The Journal of biological chemistry 2018
Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer
M Wojcik, M Krawczyk, P Wojcik, K Cypryk, LA Wozniak
Oxidative medicine and cellular longevity 2018
Glycated LDL-C and glycated HDL-C in association with adiposity, blood and atherogenicity indices in metabolic syndrome patients with and without prediabetes
RM Saudi, V Kasabri, R Naffa, N Bulatova, Y Bustanji
Therapeutic Advances in Endocrinology and Metabolism 2018
The Global Epidemic of the Metabolic Syndrome
MG Saklayen
Current Hypertension Reports 2018
High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion
TA Almabrouk, AD White, AB Ugusman, DS Skiba, OJ Katwan, H Alganga, TJ Guzik, RM Touyz, IP Salt, S Kennedy
Frontiers in physiology 2018
Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA
R Fukui, C Yamamoto, F Matsumoto, M Onji, T Shibata, Y Murakami, A Kanno, T Hayashi, N Tanimura, N Yoshida, K Miyake
Frontiers in immunology 2018
Research Advances in the Correlation between Peroxisome Proliferator-Activated Receptor- γ and Digestive Cancers
S Xu, X Xu
PPAR Research 2018
Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis
ML Ojeda, F Nogales, A Membrilla, O Carreras
European Journal of Nutrition 2018
AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis
I Cordero-Herrera, M Kozyra, Z Zhuge, SM Haworth, C Moretti, M Peleli, M Caldeira-Dias, A Jahandideh, H Huirong, J de Campos Cruz, AL Kleschyov, MF Montenegro, M Ingelman-Sundberg, E Weitzberg, JO Lundberg, M Carlstrom
Proceedings of the National Academy of Sciences 2018
Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice
B Kim, J Kwon, MS Kim, H Park, Y Ji, W Holzapfel, CK Hyun, MB Aguila
PloS one 2018
Wnt‐induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease
P Cisternas, JM Zolezzi, M Martinez, VI Torres, GW Wong, NC Inestrosa
Journal of Neurochemistry 2018
Metformin as a geroprotector: experimental and clinical evidence.
Piskovatska V, Stefanyshyn N, Storey KB, Vaiserman AM, Lushchak O
Biogerontology 2018
Mitochondrial energetics in the kidney
P Bhargava, RG Schnellmann
Nature Reviews Nephrology 2017
CD36 in chronic kidney disease: novel insights and therapeutic opportunities
X Yang, DM Okamura, X Lu, Y Chen, J Moorhead, Z Varghese, XZ Ruan
Nature Reviews Nephrology 2017
The Role of O-GlcNAcylation in Perivascular Adipose Tissue Dysfunction of Offspring of High-Fat Diet-Fed Rats
KE Zaborska, G Edwards, C Austin, M Wareing
Journal of Vascular Research 2017
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging
SJ Park, O Gavrilova, AL Brown, JE Soto, S Bremner, J Kim, X Xu, S Yang, JH Um, LG Koch, SL Britton, RL Lieber, A Philp, K Baar, SG Kohama, ED Abel, MK Kim, JH Chung
Cell Metabolism 2017
Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet
MR Lee, K Park, J Ma
Nutrients 2017
Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets
Y Chen, H Ma, D Zhu, G Zhao, L Wang, X Fu, W Chen
PPAR Research 2017
Macrophage functions in lean and obese adipose tissue
D Thomas, C Apovian
Metabolism 2017
Increased expression of triggering receptor expressed on myeloid cells-1 in the population with obesity and insulin resistance: TREM-1 Regulates Insulin Resistance
S Subramanian, PK Pallati, V Rai, P Sharma, DK Agrawal, KC Nandipati
Obesity 2017
Adiponectin induced AMP-activated protein kinase impairment mediates insulin resistance in Bama mini-pig fed high-fat and high-sucrose diet
M Niu, L Xiang, Y Liu, Y Zhao, J Yuan, X Dai, H Chen
Asian-Australasian Journal of Animal Sciences 2017
EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?
M López
European Journal of Endocrinology 2017
AMPK β1 reduces tumor progression and improves survival in p53 null mice
VP Houde, S Donzelli, A Sacconi, S Galic, JA Hammill, JL Bramson, RA Foster, T Tsakiridis, BE Kemp, G Grasso, G Blandino, P Muti, GR Steinberg
Molecular Oncology 2017
FAMPKα1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development
J Zhao, Q Yang, L Zhang, X Liang, X Sun, B Wang, Y Chen, M Zhu, M Du
Biochemical and Biophysical Research Communications 2017
Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats:
YM Park, J Padilla, JA Kanaley, TM Zidon, RJ Welly, SL Britton, LG Koch, JP Thyfault, FW Booth, VJ Vieira-Potter
Medicine and Science in Sports and Exercise 2017
Dynamics of diabetes and obesity: Epidemiological perspective
A Boles, R Kandimalla, PH Reddy
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2017
Aging metabolism: Intervention strategies
E Martinez
Virulence 2017
Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes
R Shah, V Murthy, M Pacold, K Danielson, K Tanriverdi, MG Larson, K Hanspers, A Pico, E Mick, J Reis, S Ferranti, E Freinkman, D Levy, U Hoffmann, S Osganian, S Das, JE Freedman
Diabetes care 2017
Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms
F Damiano, A Rochira, A Gnoni, L Siculella
International journal of molecular sciences 2017
Role of free fatty acids in endothelial dysfunction
A Ghosh, L Gao, A Thakur, PM Siu, CW Lai
Journal of Biomedical Science 2017
Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Mediators of Insulin Sensitivity in Prenatal Testosterone–Treated Female Sheep
M Puttabyatappa, V Andriessen, M Mesquitta, L Zeng, S Pennathur, V Padmanabhan
Endocrinology 2017
Liraglutide ameliorates cardiotoxicity induced by doxorubicin in rats through the Akt/GSK-3β signaling pathway
NA Abbas, SL Kabil
Naunyn-Schmiedeberg's Archives of Pharmacology 2017
FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle
DG Lassiter, C Nylén, RJ Sjögren, AV Chibalin, H Wallberg-Henriksson, E Näslund, A Krook, JR Zierath
Diabetologia 2017
Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells
X Chen, X Zhao, F Lan, T Zhou, H Cai, H Sun, W Kong, W Kong
Scientific Reports 2017
Fasting increases the phosphorylation of AMPK and expression of sirtuin1 in muscle of adult male northern elephant seals ( Mirounga angustirostris )
D Lee, B Martinez, DE Crocker, RM Ortiz
Physiological Reports 2017
Identification of AMPK activator from twelve pure compounds isolated from Aralia Taibaiensis : implication in antihyperglycemic and hypolipidemic activities
Y Li, J Park, Y Wu, J Cui, N Jia, M Xi, A Wen
The Korean Journal of Physiology & Pharmacology 2017
Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
D Dutta, S Kalra, M Sharma
Journal of Postgraduate Medicine 2017
AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice
L Carneiro, M Asrih, C Repond, C Sempoux, JC Stehle, C Leloup, FR Jornayvaz, L Pellerin
Molecular Metabolism 2017
Does eating less make you live longer and better? An update on calorie restriction
A Picca, V Pesce, AM Lezza
Clinical Interventions in Aging 2017
Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
D Gui, Z Cui, L Zhang, C Yu, D Yao, M Xu, M Chen, P Wu, G Li, L Wang, X Huang
BMC Pulmonary Medicine 2017
The essential role of exercise in the management of type 2 diabetes
JP Kirwan, J Sacks, S Nieuwoudt
Cleveland Clinic journal of medicine 2017
Metabolic Alterations at the Crossroad of Aging and Oncogenesis
Raffaghello L, Longo V
International review of cell and molecular biology 2017
PKCδ Inhibition Normalizes Wound Healing Capacity of Diabetic Human Fibroblasts
Mogher Khamaisi, Sayaka Katagiri, Hillary Keenan, Kyoungmin Park, Yasutaka Maeda, Weier Qi, Qian Li, Thomas Thomou, Danielle Eschuk, Ana Tellechea, Aristidis Veves, Chenyu Huang, Dennis P. Orgill, Amy Wagers, George Liang King
Journal of Clinical Investigation 2016
Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
AK Rines, K Sharabi, CD Tavares, P Puigserver
Nature Reviews Drug Discovery 2016
FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
A Salminen, A Kauppinen, K Kaarniranta
Journal of Molecular Medicine 2016
Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders
KH Su, C Dai
Cellular and Molecular Life Sciences 2016
Combatting type 2 diabetes by turning up the heat
P Schrauwen, WD van Lichtenbelt
Diabetologia 2016
Metformin revisited: Does this regulator of AMP-activated protein kinase secondarily affect bone metabolism and prevent diabetic osteopathy
AD McCarthy, AM Cortizo, C Sedlinsky
World journal of diabetes 2016
Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells
J Li, J Song, HL Weiss, T Weiss, CM Townsend, BM Evers
Molecular Endocrinology 2016
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
EP Mottillo, EM Desjardins, JD Crane, BK Smith, AE Green, S Ducommun, TI Henriksen, IA Rebalka, A Razi, K Sakamoto, C Scheele, BE Kemp, TJ Hawke, J Ortega, JG Granneman, GR Steinberg
Cell Metabolism 2016
Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance
KC Nandipati, S Subramanian, DK Agrawal
Molecular and Cellular Biochemistry 2016
Regulation and function of AMPK in physiology and diseases
SM Jeon
Experimental & molecular medicine 2016
Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?
K Rehman, MS Akash
Journal of Biomedical Science 2016
Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts
Y Ding, J Chen, IS Okon, MH Zou, P Song
The International Journal of Biochemistry & Cell Biology 2016
Hypothalamic AMPK: a canonical regulator of whole-body energy balance
M López, R Nogueiras, M Tena-Sempere, C Diéguez
Nature Reviews Endocrinology 2016
Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
X Luo, J Wu, S Jing, LJ Yan
Aging and disease 2016
Intermedin Restores Hyperhomocysteinemia-induced Macrophage Polarization and Improves Insulin Resistance in Mice
Y Pang, Y Li, Y Lv, L Sun, S Zhang, Y Li, Y Wang, G Liu, MJ Xu, X Wang, C Jiang
The Journal of biological chemistry 2016
Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice
Q Kong, H Zhang, T Zhao, W Zhang, M Yan, X Dong, P Li
International journal of molecular medicine 2016
CD36 actions in the heart: Lipids, calcium, inflammation, repair and more?
NA Abumrad, IJ Goldberg
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2016
AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages
F Kumase, K Takeuchi, Y Morizane, J Suzuki, H Matsumoto, K Kataoka, A Al-Moujahed, DE Maidana, JW Miller, DG Vavvas, NK Karamanos
PloS one 2016
Obesity decreases B cell responses in young and elderly individuals: Obesity, Aging, and B Cell Function
D Frasca, F Ferracci, A Diaz, M Romero, S Lechner, BB Blomberg
Obesity 2016
Metformin attenuates lung fibrosis development via NOX4 suppression
N Sato, N Takasaka, M Yoshida, K Tsubouchi, S Minagawa, J Araya, N Saito, Y Fujita, Y Kurita, K Kobayashi, S Ito, H Hara, T Kadota, H Yanagisawa, M Hashimoto, H Utsumi, H Wakui, J Kojima, T Numata, Y Kaneko, M Odaka, T Morikawa, K Nakayama, H Kohrogi, K Kuwano
Respiratory Research 2016
Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus
M Wang, L Luo, L Yao, C Wang, K Jiang, X Liu, M Xu, N Shen, S Guo, C Sun, Y Yang
Scientific Reports 2016
Podocyte injury: the role of proteinuria, urinary plasminogen, and oxidative stress
L Raij, R Tian, JS Wong, JC He, KN Campbell
American journal of physiology. Renal physiology 2016
Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer
S Polvani
World journal of gastroenterology : WJG 2016
Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function
Y Zhang, Z Zhao, B Ke, L Wan, H Wang, J Ye, H Xu
PloS one 2016
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet–Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase
Y Lin, J Chen, Z Sun
Hypertension 2016
Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration
M Hirasawa, K Takubo, H Osada, S Miyake, E Toda, M Endo, K Umezawa, K Tsubota, Y Oike, Y Ozawa
The Journal of biological chemistry 2016
The emerging role of AMPK in the regulation of breathing and oxygen supply
AM Evans, AD Mahmoud, J Moral-Sanz, S Hartmann
Biochemical Journal 2016
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway
H Tang, J Li, X Liu, G Wang, M Luo, H Deng
Scientific Reports 2016
Veratri Nigri Rhizoma et Radix ( Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPK α -ACC Axis In Vivo and In Vitro
J Park, YD Jeon, HL Kim, DS Kim, YH Han, Y Jung, DH Youn, JW Kang, D Yoon, MY Jeong, JH Lee, SH Hong, J Lee, JY Um
Evidence-Based Complementary and Alternative Medicine 2016
Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression
É Pepin, A Al-Mass, C Attané, K Zhang, J Lamontagne, R Lussier, SR Madiraju, E Joly, NB Ruderman, R Sladek, M Prentki, ML Peyot, A Nadal
PloS one 2016
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance
HZ Xu, YL Cheng, WN Wang, H Wu, YY Zhang, CS Zang, ZG Xu
International journal of molecular sciences 2016
AMPK Negatively Regulates Peripheral Myelination via Activation of c-Jun
X Liu, S Peng, Y Zhao, T Zhao, M Wang, L Luo, Y Yang, C Sun
Molecular Neurobiology 2016
Deubiquitination and Activation of AMPK by USP10
M Deng, X Yang, B Qin, T Liu, H Zhang, W Guo, SB Lee, JJ Kim, J Yuan, H Pei, L Wang, Z Lou
Molecular Cell 2016
Stress kinases, endoplasmic reticulum stress, and Alzheimer’s disease related markers in peripheral blood mononuclear cells from subjects with increased body weight
T Lei, L Yu, L Qin, B Xu, L Zhou, J Cheng, H Zhou, X Pang, Z Wan
Scientific Reports 2016
Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis
C Coyle, FH Cafferty, C Vale, RE Langley
Annals of Oncology 2016
Olive Leaf Extract from Sicilian Cultivar Reduced Lipid Accumulation by Inducing Thermogenic Pathway during Adipogenesis
R Palmeri, JI Monteleone, G Spagna, C Restuccia, M Raffaele, L Vanella, GL Volti, I Barbagallo
Frontiers in pharmacology 2016
Ovariectomized Highly Fit Rats Are Protected against Diet-Induced Insulin Resistance:
YM Park, JA Kanaley, TM Zidon, RJ Welly, RJ Scroggins, SL Britton, LG Koch, JP Thyfault, FW Booth, J Padilla, VJ Vieira-Potter
Medicine and Science in Sports and Exercise 2016
Unraveling the actions of AMP-activated protein kinase in metabolic diseases: Systemic to molecular insights
KA Weikel, NB Ruderman, JM Cacicedo
Metabolism 2016
Stimulatory Effect of Balanced Deep-Sea Water Containing Chitosan Oligosaccharides on Glucose Uptake in C2C12 Myotubes
BG Ha, JE Park, YH Shon
Marine Biotechnology 2016
Mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone induces vasorelaxation without involving K ATP channel activation in smooth muscle cells of arteries: CCCP induces vasorelaxation
YQ Zhang, X Shen, XL Xiao, MY Liu, SL Li, J Yan, J Jin, JL Gao, CL Zhen, N Hu, XZ Zhang, Y Tai, LS Zhang, YL Bai, DL Dong
British Journal of Pharmacology 2016
AMP-activated Protein Kinase Deficiency Blocks the Hypoxic Ventilatory Response and Thus Precipitates Hypoventilation and Apnea
AD Mahmoud, S Lewis, L Juričić, UA Udoh, S Hartmann, MA Jansen, OA Ogunbayo, P Puggioni, AP Holmes, P Kumar, J Navarro-Dorado, M Foretz, B Viollet, MB Dutia, I Marshall, AM Evans
American journal of respiratory and critical care medicine 2016
Loss of anti-contractile effect of perivascular adipose tissue in offspring of obese rats
KE Zaborska, M Wareing, G Edwards, C Austin
International Journal of Obesity 2016
Newer antidiabetic drugs and calorie restriction mimicry
S Kalra, JJ Jacob, Y Gupta
Indian journal of endocrinology and metabolism 2016
Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity
L Jia, W Li, J Li, Y Li, H Song, Y Luan, H Qi, L Ma, X Lu, Y Yang
Scientific Reports 2016
Liraglutide prevents microvascular insulin resistance and preserves muscle capillary density in high-fat diet-fed rats
W Chai, Z Fu, KW Aylor, EJ Barrett, Z Liu
American journal of physiology. Endocrinology and metabolism 2016
Protein kinase C phosphorylates AMP-activated protein kinase  1 Ser487
HR Heathcote, SJ Mancini, A Strembitska, K Jamal, JA Reihill, TM Palmer, GW Gould, IP Salt
Biochemical Journal 2016
Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityNovelty and Significance
D Gao, Z Zuo, J Tian, Q Ali, Y Lin, H Lei, Z Sun
Hypertension 2016
The 13C-Glucose Breath Test for Insulin Resistance Assessment in Adolescents: Comparison with Fasting and Post-Glucose Stimulus Surrogate Markers of Insulin Resistance
J Maldonado-Hernández, A Martínez-Basila, A Salas-Fernández, JR Navarro-Betancourt, MI Piña-Aguero, M Bernabe-García
Journal of clinical research in pediatric endocrinology 2016
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
RJ Ford, MD Fullerton, SL Pinkosky, EA Day, JW Scott, JS Oakhill, AL Bujak, BK Smith, JD Crane, RM Blümer, K Marcinko, BE Kemp, HC Gerstein, GR Steinberg
Biochemical Journal 2015
Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis
R Mohamed, C Jayakumar, F Chen, D Fulton, D Stepp, RT Gansevoort, G Ramesh
Journal of the American Society of Nephrology : JASN 2015
Hematopoietic Tissue Factor–Protease-Activated Receptor 2 Signaling Promotes Hepatic Inflammation and Contributes to Pathways of Gluconeogenesis and Steatosis in Obese Mice
J Wang, S Chakrabarty, Q Bui, W Ruf, F Samad
The American Journal of Pathology 2015
Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes
Y Matsumoto, M Ishii, Y Hayashi, S Miyazaki, T Sugita, E Sumiya, K Sekimizu
Scientific Reports 2015
The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
K Marcinko, AL Bujak, JS Lally, RJ Ford, TH Wong, BK Smith, BE Kemp, Y Jenkins, W Li, TM Kinsella, Y Hitoshi, GR Steinberg
Molecular Metabolism 2015
AMPK: energy sensor and survival mechanism in the ischemic heart
D Qi, LH Young
Trends in Endocrinology & Metabolism 2015
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model
M Amrutkar, E Cansby, U Chursa, E Nuñez-Durán, B Chanclón, M Ståhlman, V Fridén, L Mannerås-Holm, A Wickman, U Smith, F Bäckhed, J Borén, BW Howell, M Mahlapuu
Diabetes 2015
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology
X Chen, Y Lu, Z Zhang, J Wang, H Yang, G Liu
Immunology 2015
Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II
D Macconi, L Perico, L Longaretti, M Morigi, P Cassis, S Buelli, N Perico, G Remuzzi, A Benigni, JA Joles
PloS one 2015
Potential therapeutic effects of mTOR inhibition in atherosclerosis: mTOR inhibition in atherosclerosis
A Kurdi, GR de Meyer, W Martinet
British Journal of Clinical Pharmacology 2015
Mechanisms for independent and combined effects of calorie restriction and acute exercise on insulin-stimulated glucose uptake by skeletal muscle of old rats
N Sharma, H Wang, EB Arias, CM Castorena, GD Cartee
American journal of physiology. Endocrinology and metabolism 2015
Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise
H Wang, N Sharma, EB Arias, GD Cartee
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2015
Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
MJ Hanssen, J Hoeks, B Brans, AA van der Lans, G Schaart, JJ van Driessche, JA Jörgensen, MV Boekschoten, MK Hesselink, B Havekes, S Kersten, FM Mottaghy, WD van Lichtenbelt, P Schrauwen
Nature Medicine 2015
Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling
RA Sinha, BK Singh, J Zhou, Y Wu, BL Farah, K Ohba, R Lesmana, J Gooding, BH Bay, PM Yen
Autophagy 2015
Interventions to Slow Aging in Humans: Are We Ready?
VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown-Borg, C Caruso, TJ Curiel, R Cabo, C Franceschi, D Gems, DK Ingram, TE Johnson, BK Kennedy, C Kenyon, S Klein, JJ Kopchick, G Lepperdinger, F Madeo, MG Mirisola, JR Mitchell, G Passarino, KL Rudolph, JM Sedivy, GS Shadel, DA Sinclair, SR Spindler, Y Suh, J Vijg, M Vinciguerra, L Fontana
Aging Cell 2015
Vascular function, insulin action, and exercise: an intricate interplay
C Zheng, Z Liu
Trends in Endocrinology & Metabolism 2015
p -Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells
Z Cui, Y Lee, Y Lee, D Park
Journal of Medicinal Food 2015
High-fat diet combined with low-dose streptozotocin injections induces metabolic syndrome in Macaca mulatta
L Li, G Liao, G Yang, Y Lu, X Du, J Liu, L Li, C Wang, L Li, Y Ren, Z Zhong, J Cheng, Y Chen
Endocrine 2015
A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice
CI Rousset, FC Leiper, A Kichev, P Gressens, D Carling, H Hagberg, C Thornton
Journal of Neurochemistry 2015
Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes
Y Ido, A Duranton, F Lan, KA Weikel, L Breton, NB Ruderman, M López
PloS one 2015
Free Access to a Running-Wheel Advances the Phase of Behavioral and Physiological Circadian Rhythms and Peripheral Molecular Clocks in Mice
Y Yasumoto, R Nakao, K Oishi, H Oster
PloS one 2015
Insulin Resistance Is Associated with Intraocular Pressure Elevation in a Non-Obese Korean Population
YH Chun, K Han, SH Park, KM Park, HW Yim, WC Lee, YG Park, YM Park, SL Atkin
PloS one 2015
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo
Y Wu, P Song, W Zhang, J Liu, X Dai, Z Liu, Q Lu, C Ouyang, Z Xie, Z Zhao, X Zhuo, B Viollet, M Foretz, J Wu, Z Yuan, MH Zou
Nature Medicine 2015
Adiponectin Deficiency Contributes to Sensitivity in Human Skin
EJ Kim, DH Lee, YK Kim, HC Eun, JH Chung
Journal of Investigative Dermatology 2015
The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link
LW Bowers, EL Rossi, CH O’Flanagan, LA deGraffenried, SD Hursting
Frontiers in Endocrinology 2015
Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice
ES Koh, JH Lim, MY Kim, S Chung, SJ Shin, BS Choi, HW Kim, SY Hwang, SW Kim, CW Park, YS Chang
Journal of Translational Medicine 2015
DPP-4 Inhibitor Linagliptin Attenuates A β -induced Cytotoxicity through Activation of AMPK in Neuronal Cells
E Kornelius, CL Lin, HH Chang, HH Li, WN Huang, YS Yang, YL Lu, CH Peng, CN Huang
CNS Neuroscience & Therapeutics 2015
Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism
KY Lee, MK Singh, S Ussar, P Wetzel, MF Hirshman, LJ Goodyear, A Kispert, CR Kahn
Nature Communications 2015
Improved insulin sensitivity 3 months after RYGB surgery is associated with increased subcutaneous adipose tissue AMPK activity and decreased oxidative stress
XJ Xu, C Apovian, D Hess, B Carmine, A Saha, N Ruderman
Diabetes 2015
A Taiwanese Nationwide Cohort Study Shows Interferon-Based Therapy for Chronic Hepatitis C Reduces the Risk of Chronic Kidney Disease:
YC Chen, SJ Hwang, CY Li, CP Wu, LC Lin
Medicine 2015
Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
D Zhang, J Zhang, Y Wang, Y Liu, G Liu, X Li
Nutrients 2015
Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle
Y Shimoda, K Matsuo, Y Kitamura, K Ono, T Ueyama, S Matoba, H Yamada, T Wu, J Chen, N Emoto, K Ikeda, JV Planas
PloS one 2015
Diacylglycerol Kinase δ Regulates AMPK Signaling, Lipid Metabolism and Skeletal Muscle Energetics
LQ Jiang, TD Barbosa, J Massart, AS Deshmukh, L Löfgren, DE Duque-Guimaraes, A Ozilgen, ME Osler, AV Chibalin, JR Zierath
American journal of physiology. Endocrinology and metabolism 2015
Anti-Obesity Effect of 6,8-Diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice
Y Jo, KM Choi, Q Liu, S Kim, HJ Ji, M Kim, SK Shin, SG Do, E Shin, G Jung, HS Yoo, B Hwang, M Lee
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Mechanism of Butyrate Stimulation of Triglyceride Storage and Adipokine Expression during Adipogenic Differentiation of Porcine Stromovascular Cells
H Yan, KM Ajuwon, D Nie
PloS one 2015
Liver enzymes and metabolic syndrome: a large-scale case-control study
L Zhang, X Ma, Z Jiang, K Zhang, M Zhang, Y Li, X Zhao, H Xiong
Oncotarget 2015
Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress
LJ Yan
Journal of Diabetes Research 2014
Thyroid Hormone Regulation of Metabolism
R Mullur, YY Liu, GA Brent
Physiological reviews 2014
Cardiomyocyte health: adapting to metabolic changes through autophagy
DA Kubli, ÅB Gustafsson
Trends in Endocrinology & Metabolism 2014
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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014
Nonalcoholic Fatty Liver Disease: Pathogenesis and Therapeutics from a Mitochondria-Centric Perspective
AM Gusdon, K Song, S Qu
Oxidative medicine and cellular longevity 2014
Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
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Physiological reviews 2014
Role of the Unfolded Protein Response in β Cell Compensation and Failure during Diabetes
N Rabhi, E Salas, P Froguel, JS Annicotte
Journal of Diabetes Research 2014
Increased Subcutaneous Adipose Tissue Expression of Genes Involved in Glycerolipid-Fatty Acid Cycling in Obese Insulin-Resistant Versus -Sensitive Individuals
MS Gauthier, JR Pérusse, MÈ Lavoie, R Sladek, SR Madiraju, NB Ruderman, B Coulombe, M Prentki, R Rabasa-Lhoret
The Journal of clinical endocrinology and metabolism 2014
Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
D Sorriento, AV Pascale, R Finelli, AL Carillo, R Annunziata, B Trimarco, G Iaccarino
The Scientific World JOURNAL 2014
Artemisia scoparia Enhances Adipocyte Development and Endocrine Function In Vitro and Enhances Insulin Action In Vivo
AJ Richard, S Fuller, V Fedorcenco, R Beyl, TP Burris, R Mynatt, DM Ribnicky, JM Stephens
PloS one 2014
Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle
KE Boyle, H Hwang, RC Janssen, JM DeVente, LA Barbour, TL Hernandez, LJ Mandarino, M Lappas, JE Friedman
PloS one 2014
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
S Ducommun, RJ Ford, L Bultot, M Deak, L Bertrand, BE Kemp, GR Steinberg, K Sakamoto
American journal of physiology. Endocrinology and metabolism 2014
SIK2 regulates insulin secretion
BF Belgardt, M Stoffel
Nature Cell Biology 2014
AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity?
XJ Xu, RJ Valentine, NB Ruderman
Current Obesity Reports 2014
Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation
D Samovski, J Sun, T Pietka, RW Gross, RH Eckel, X Su, PD Stahl, NA Abumrad
Diabetes 2014
Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats
J Fu, Y Han, H Wang, Z Wang, Y Liu, X Chen, Y Cai, W Guan, D Yang, LD Asico, L Zhou, PA Jose, C Zeng
Cardiovascular Diabetology 2014
New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate
HS Kim, MJ Quon, JA Kim
Redox Biology 2014
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SS Gori, P Lorkiewicz, DS Ehringer, AC Belshoff, RM Higashi, TW Fan, MH Nantz
Analytical and Bioanalytical Chemistry 2014
Signaling pathway cross talk in Alzheimer's disease
JA Godoy, JA Rios, JM Zolezzi, N Braidy, NC Inestrosa
Cell Communication and Signaling 2014
Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle
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Archives of Biochemistry and Biophysics 2014
Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
C Liang, BJ Curry, PL Brown, MB Zemel
Journal of nutrition and metabolism 2014
Metabolic syndrome and diabetes for the urologist
NE Fleshner, B Bhindi
Canadian Urological Association Journal 2014
Metabolic Syndrome Exacerbates Inflammation and Bone Loss in Periodontitis
Y Li, Z Lu, X Zhang, H Yu, KL Kirkwood, MF Lopes-Virella, Y Huang
Journal of dental research 2014
AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages
Y Wang, B Viollet, R Terkeltaub, R Liu-Bryan
Annals of the rheumatic diseases 2014
Elevated levels of TWEAK in skeletal muscle promote visceral obesity, insulin resistance, and metabolic dysfunction
S Sato, Y Ogura, MM Tajrishi, A Kumar
The FASEB Journal 2014
Experimental Studies of the Molecular Pathways Regulated by Exercise and Resveratrol in Heart, Skeletal Muscle and the Vasculature
V Dolinsky, J Dyck
Molecules (Basel, Switzerland) 2014
Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway
JH Lee, JY Jung, EJ Jang, KH Jegal, SY Moon, SK Ku, SH Kang, IJ Cho, SJ Park, JR Lee, RJ Zhao, SC Kim, YW Kim
Experimental biology and medicine (Maywood, N.J.) 2014
SIRT1 metabolic actions: Integrating recent advances from mouse models
M Boutant, C Cantó
Molecular Metabolism 2013
The Role of INDY in Metabolic Regulation
DM Willmes, AL Birkenfeld
Computational and Structural Biotechnology Journal 2013
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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