Clash of the microbes: let’s bring back the good guys
Martin J. Wolff, … , Michael A. Poles, Judith A. Aberg
Martin J. Wolff, … , Michael A. Poles, Judith A. Aberg
Published January 16, 2013
Citation Information: J Clin Invest. 2013;123(2):544-545. https://doi.org/10.1172/JCI66736.
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The Attending Physician

Clash of the microbes: let’s bring back the good guys

Abstract

A 38-year-old man with a history of HIV infection virologically suppressed on antiretroviral therapy presents to his gastroenterologist for evaluation of iron deficiency anemia and weight loss. A diagnostic colonoscopy demonstrates a two-centimeter ulcerated mass in the cecum. Biopsies of the lesion return moderately differentiated adenocarcinoma that is wild type for the KRAS mutation by real-time PCR.

Authors

Martin J. Wolff, Michael A. Poles, Judith A. Aberg

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Figure 1

Endoscopic and histological analysis of the terminal ileum in an HIV-uninfected (A) and HIV-infected patient (B).

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Endoscopic and histological analysis of the terminal ileum in an HIV-uni...
Immunohistological staining for CD4 was performed by sectioning biopsies from ileal lymphoid tissue followed by H&E staining and immunostaining for CD4 (C and D). Reproduced with permission from The Journal of Experimental Medicine (2).