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Are epsins a therapeutic target for tumor angiogenesis?
Nancy Klauber-DeMore
Nancy Klauber-DeMore
Published November 26, 2012
Citation Information: J Clin Invest. 2012;122(12):4341-4343. https://doi.org/10.1172/JCI66171.
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Commentary Article has an altmetric score of 11

Are epsins a therapeutic target for tumor angiogenesis?

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Abstract

Solid tumor growth requires the formation of new blood vessels to supply nutrients and oxygen to the malignant cells; one approach to cancer therapy is to block this process by inhibiting VEGF signaling. In this issue of the JCI, Pasula et al. demonstrate a surprising role of epsins — proteins involved in endocytosis — in tumor angiogenesis via their modulation of VEGF signaling. Their findings suggest that these proteins might represent a new target for the development of cancer therapeutics.

Authors

Nancy Klauber-DeMore

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