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Supply-side and trickle-down therapy
Gregory A. Grabowski
Gregory A. Grabowski
Published February 15, 1999
Citation Information: J Clin Invest. 1999;103(4):439-440. https://doi.org/10.1172/JCI6290.
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Commentary

Supply-side and trickle-down therapy

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Abstract

Authors

Gregory A. Grabowski

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Figure 1

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Substrate flux is determined by various input and output rates including...
Substrate flux is determined by various input and output rates including substrate synthesis, but other factors, including alternative metabolic pathways, environmental exposures, cell type, or tissue region, etc., can significantly influence this rate. “S” indicates a steady state level of substrate that is not necessarily normal. A significant issue is the level of substrate that is compatible with normalcy. The rate of “S” increase determines the age of onset and progression of metabolic diseases.

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