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Citations to this article

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
Thomas Jamieson, … , Robert J.B. Nibbs, Owen J. Sansom
Thomas Jamieson, … , Robert J.B. Nibbs, Owen J. Sansom
Published August 27, 2012
Citation Information: J Clin Invest. 2012;122(9):3127-3144. https://doi.org/10.1172/JCI61067.
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Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

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Abstract

The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through multiple mechanisms and might promote or inhibit tumor development depending on context. Here, we used several mouse models of spontaneous and inflammation-driven neoplasia to define indispensable roles for CXCR2 in benign and malignant tumors. CXCR2-activating chemokines were part of the secretome of cultured primary benign intestinal adenomas (ApcMin/+) and highly expressed by all tumors in all models. CXCR2 deficiency profoundly suppressed inflammation-driven tumorigenesis in skin and intestine as well as spontaneous adenocarcinoma formation in a model of invasive intestinal adenocarcinoma (AhCreER;Apcfl/+;Ptenfl/fl mice). Pepducin-mediated CXCR2 inhibition reduced tumorigenesis in ApcMin/+ mice. Ly6G+ neutrophils were the dominant source of CXCR2 in blood, and CXCR2 deficiency attenuated neutrophil recruitment. Moreover, systemic Ly6G+ cell depletion purged CXCR2-dependent tumor-associated leukocytes, suppressed established skin tumor growth and colitis-associated tumorigenesis, and reduced ApcMin/+ adenoma formation. CXCR2 is thus a potent protumorigenic chemokine receptor that directs recruitment of tumor-promoting leukocytes into tissues during tumor-inducing and tumor-driven inflammation. Similar leukocyte populations were also found in human intestinal adenomas, which suggests that CXCR2 antagonists may have therapeutic and prophylactic potential in the treatment of cancer.

Authors

Thomas Jamieson, Mairi Clarke, Colin W. Steele, Michael S. Samuel, Jens Neumann, Andreas Jung, David Huels, Michael F. Olson, Sudipto Das, Robert J.B. Nibbs, Owen J. Sansom

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The Phosphatidic Acid Phosphatase Lipin-1 Facilitates Inflammation-Driven Colon Carcinogenesis
Clara Meana, Ginesa Garcia - Rostan, Lucía Peña, Gema Lordén, Africa Cubero, Antonio Orduña, Balázs Győrffy, Jesús Balsinde, Maria A. Balboa
JCI Insight 2018
Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion
A Marazioti, I Lilis, M Vreka, H Apostolopoulou, A Kalogeropoulou, I Giopanou, GA Giotopoulou, AC Krontira, M Iliopoulou, NI Kanellakis, T Agalioti, AD Giannou, C Jones-Paris, Y Iwakura, D Kardamakis, TS Blackwell, S Taraviras, M Spella, GT Stathopoulos
Nature Communications 2018
Roles of the immune system in cancer: from tumor initiation to metastatic progression
H Gonzalez, C Hagerling, Z Werb
Genes & development 2018
Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options
D Kabacaoglu, KJ Ciecielski, DA Ruess, H Algül
Frontiers in immunology 2018
The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
V Poltavets, M Kochetkova, SM Pitson, MS Samuel
Frontiers in Oncology 2018
Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering
G Rijal, W Li
Journal of biological engineering 2018
Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells
J Zhou, Y Nefedova, A Lei, D Gabrilovich
Seminars in Immunology 2018
FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation: Suppression of urothelial inflammation by FGFR3
M Foth, NF Ismail, JS Kung, D Tomlinson, MA Knowles, P Eriksson, G Sjödahl, JM Salmond, OJ Sansom, T Iwata
The Journal of Pathology 2018
Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy
EJ Clappaert, A Murgaski, HV Damme, M Kiss, D Laoui
Frontiers in immunology 2018
Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis
H Yuan, X Wang, C Shi, L Jin, J Hu, A Zhang, J Li, N Vijayendra, V Doodala, S Weiss, Y Tang, LM Weiner, RI Glazer
Scientific Reports 2018
MMTV-NeuT/ATTAC mice: a new model for studying the stromal tumor microenvironment
H Yuan, X Wang, J Lu, Q Zhang, I Brandina, I Alexandrov, RI Glazer
Oncotarget 2018
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence
TG Bird, M Müller, L Boulter, DF Vincent, RA Ridgway, E Lopez-Guadamillas, WY Lu, T Jamieson, O Govaere, AD Campbell, S Ferreira-Gonzalez, AM Cole, T Hay, KJ Simpson, W Clark, A Hedley, M Clarke, P Gentaz, C Nixon, S Bryce, C Kiourtis, J Sprangers, RJ Nibbs, NV Rooijen, L Bartholin, SR McGreal, U Apte, ST Barry, JP Iredale, AR Clarke, M Serrano, TA Roskams, OJ Sansom, SJ Forbes
Science Translational Medicine 2018
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells
L Chung, ET Orberg, AL Geis, JL Chan, K Fu, CE Shields, CM Dejea, P Fathi, J Chen, BB Finard, AJ Tam, F McAllister, H Fan, X Wu, S Ganguly, A Lebid, P Metz, SW van Meerbeke, DL Huso, EC Wick, DM Pardoll, F Wan, S Wu, CL Sears, F Housseau
Cell Host & Microbe 2018
Understanding the tumor immune microenvironment (TIME) for effective therapy
M Binnewies, EW Roberts, K Kersten, V Chan, DF Fearon, M Merad, LM Coussens, DI Gabrilovich, S Ostrand-Rosenberg, CC Hedrick, RH Vonderheide, MJ Pittet, RK Jain, W Zou, TK Howcroft, EC Woodhouse, RA Weinberg, MF Krummel
Nature Medicine 2018
Tumor-infiltrating neutrophils predict prognosis and adjuvant chemotherapeutic benefit in patients with biliary cancer
J Wang, X Bo, T Suo, H Liu, X Ni, S Shen, M Li, J Xu, H Liu, Y Wang
Cancer Science 2018
Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
R Schulz-Heddergott, N Stark, SJ Edmunds, J Li, LC Conradi, H Bohnenberger, F Ceteci, FR Greten, M Dobbelstein, UM Moll
Cancer Cell 2018
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
MA Meyer, JM Baer, BL Knolhoff, TM Nywening, RZ Panni, X Su, KN Weilbaecher, WG Hawkins, C Ma, RC Fields, DC Linehan, GA Challen, R Faccio, RL Aft, DG DeNardo
Nature Communications 2018
Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment
A Martin, C Seignez, C Racoeur, N Isambert, N Mabrouk, A Scagliarini, S Reveneau, L Arnould, A Bettaieb, JF Jeannin, C Paul
Oncotarget 2018
Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression
Z Tan, L Liu, MS Chiu, KW Cheung, CW Yan, Z Yu, BK Lee, W Liu, K Man, Z Chen
OncoImmunology 2018
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer
S Wagner, G Vlachogiannis, AD Brandon, M Valenti, G Box, L Jenkins, C Mancusi, A Self, F Manodoro, I Assiotis, P Robinson, R Chauhan, AG Rust, N Matthews, K Eason, K Khan, N Starling, D Cunningham, A Sadanandam, CM Isacke, V Kirkin, N Valeri, SR Whittaker
Oncogene 2018
CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer
SC las Heras, E Martínez-Balibrea
World journal of gastroenterology : WJG 2018
Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice
D Triner, SN Devenport, SK Ramakrishnan, X Ma, RA Frieler, JK Greenson, N Inohara, G Nunez, JA Colacino, RM Mortensen, YM Shah
Gastroenterology 2018
Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3 + regulatory T cells in murine colon cancer
X Chen, Y Takemoto, H Deng, M Middelhoff, RA Friedman, TH Chu, MJ Churchill, Y Ma, KK Nagar, YH Tailor, S Mukherjee, TC Wang
OncoImmunology 2017
Insulin resistance in vascular endothelial cells promotes intestinal tumour formation
X Wang, MF Häring, T Rathjen, SM Lockhart, D Sørensen, S Ussar, LM Rasmussen, MM Bertagnolli, CR Kahn, C Rask-Madsen
Oncogene 2017
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
H Ha, B Debnath, N Neamati
Theranostics 2017
Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury
RA Frieler, Y Chung, CG Ahlers, G Gheordunescu, J Song, TM Vigil, YM Shah, RM Mortensen
Experimental Neurology 2017
Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7
N Vachharajani, T Joeris, M Luu, S Hartmann, S Pautz, E Jenike, G Pantazis, I Prinz, MJ Hofer, U Steinhoff, A Visekruna
Oncotarget 2017
Epithelial-mesenchymal transition and inflammation at the site of the primary tumor
C Dominguez, JM David, C Palena
Seminars in Cancer Biology 2017
TREM-1 promotes intestinal tumorigenesis
L Saurer, D Zysset, S Rihs, L Mager, M Gusberti, C Simillion, A Lugli, I Zlobec, P Krebs, C Mueller
Scientific Reports 2017
Cancer Inflammation and Cytokines
MR Galdiero, G Marone, A Mantovani
Cold Spring Harbor perspectives in biology 2017
Targeting both tumour-associated CXCR2 + neutrophils and CCR2 + macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
TM Nywening, BA Belt, DR Cullinan, RZ Panni, BJ Han, DE Sanford, RC Jacobs, J Ye, AA Patel, WE Gillanders, RC Fields, DG DeNardo, WG Hawkins, P Goedegebuure, DC Linehan
Gut 2017
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
AE Baek, YR Yu, S He, SE Wardell, CY Chang, S Kwon, RV Pillai, HB McDowell, JW Thompson, LG Dubois, PM Sullivan, JK Kemper, MD Gunn, DP McDonnell, ER Nelson
Nature Communications 2017
Neutrophils in cancer: prognostic role and therapeutic strategies
A Ocana, C Nieto-Jiménez, A Pandiella, AJ Templeton
Molecular Cancer 2017
CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses
DP Dyer, K Pallas, LM Ruiz, F Schuette, GJ Wilson, GJ Graham
Scientific Reports 2017
Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues
D Powell, S Tauzin, LE Hind, Q Deng, DJ Beebe, A Huttenlocher
Cell Reports 2017
Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration
MK Nielsen, SM Hector, K Allen, Y Subhi, TL Sørensen
Immunity & Ageing 2017
Myeloid-derived suppressor cell and macrophage exert distinct angiogenic and immunosuppressive effects in breast cancer
Z Fang, C Wen, X Chen, R Yin, C Zhang, X Wang, Y Huang
Oncotarget 2017
Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates
A Qaqish, D Huang, CY Chen, Z Zhang, R Wang, S Li, E Yang, Y Lu, MH Larsen, WR Jacobs, L Qian, J Frencher, L Shen, ZW Chen
Journal of immunology (Baltimore, Md. : 1950) 2017
Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
H Wang, B Peng, RK Pandita, DA Engler, RK Matsunami, PM Hegde, BE Butler, TK Pandita, S Mitra, B Xu, ML Hegde
Oncotarget 2017
Bromoethylindole (BEI-9) redirects NF-κB signaling induced by camptothecin and TNFα to promote cell death in colon cancer cells
R Chowdhury, D Gales, P Valenzuela, S Miller, T Yehualaeshet, U Manne, G Francia, T Samuel
Apoptosis 2017
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice
K Bergstrom, X Liu, Y Zhao, N Gao, Q Wu, K Song, Y Cui, Y Li, JM McDaniel, S McGee, W Chen, MM Huycke, CW Houchen, LA Zenewicz, CM West, H Chen, J Braun, J Fu, L Xia
Gastroenterology 2016
Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma
HE Metz, J Kargl, SE Busch, KH Kim, BF Kurland, SR Abberbock, J Randolph-Habecker, SE Knoblaugh, JK Kolls, MF White, AM Houghton
Proceedings of the National Academy of Sciences 2016
Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer
TT Wei, YT Lin, WS Chen, P Luo, YC Lin, CT Shun, YH Lin, JB Chen, NW Chen, JM Fang, MS Wu, KC Yang, LC Chang, KY Tai, JT Liang, CC Chen
EBioMedicine 2016
Genetically engineered mouse models in oncology research and cancer medicine
K Kersten, KE de Visser, MH van Miltenburg, J Jonkers
EMBO Molecular Medicine 2016
Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils
D Triner, X Xue, AJ Schwartz, I Jung, JA Colacino, YM Shah
Molecular and cellular biology 2016
Clinical Association of Chemokine (C-X-C motif) Ligand 1 (CXCL1) with Interstitial Pneumonia with Autoimmune Features (IPAF)
M Liang, Z Jiang, Q Huang, L Liu, Y Xue, X Zhu, Y Yu, W Wan, H Yang, H Zou
Scientific Reports 2016
Myeloid-derived suppressor cells: The green light for myeloma immune escape
E Malek, M Lima, JJ Letterio, BG Kim, JH Finke, JJ Driscoll, SA Giralt
Blood Reviews 2016
Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α
YG Najjar, P Rayman, X Jia, PG Pavicic, BI Rini, C Tannenbaum, J Ko, S Haywood, P Cohen, T Hamilton, CM Diaz-Montero, J Finke
Clinical cancer research 2016
Neutrophils in cancer: neutral no more
SB Coffelt, MD Wellenstein, KE de Visser
Nature Reviews Cancer 2016
Neutrophils in the Tumor Microenvironment
DR Powell, A Huttenlocher
Trends in Immunology 2016
Neutrophils: Critical components in experimental animal models of cancer
C Hagerling, Z Werb
Seminars in Immunology 2016
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma
CW Steele, SA Karim, JD Leach, P Bailey, R Upstill-Goddard, L Rishi, M Foth, S Bryson, K McDaid, Z Wilson, C Eberlein, JB Candido, M Clarke, C Nixon, J Connelly, N Jamieson, CR Carter, F Balkwill, DK Chang, TR Evans, D Strathdee, AV Biankin, RJ Nibbs, ST Barry, OJ Sansom, JP Morton
Cancer Cell 2016
Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy
S Zilio, P Serafini
Human vaccines 2016
Targeting inflammation in pancreatic cancer: Clinical translation
Colin William Steele, Nina Angharad Kaur Gill, Nigel Balfour Jamieson, Christopher Ross Carter
World journal of gastrointestinal oncology 2016
Recent advances in understanding neutrophils
JF Deniset, P Kubes
F1000Research 2016
Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors
V Wieser, TE Adolph, B Enrich, A Kuliopulos, A Kaser, H Tilg, NC Kaneider
Gut 2016
Immune stimulatory effects of rapamycin are mediated by stimulation of antitumor    T cells
V Dao, Y Liu, S Pandeswara, RS Svatek, JA Gelfond, A Liu, V Hurez, TJ Curiel
Cancer research 2016
Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells
M Wakita, H Edamatsu, M Li, A Emi, S Kitazawa, T Kataoka
The Journal of biological chemistry 2016
NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression
RM Ignacio, SM Kabir, ES Lee, SE Adunyah, DS Son, JW Lee
PloS one 2016
Volatile anaesthetics enhance the metastasis related cellular signalling including CXCR2 of ovarian cancer cells
M Iwasaki, H Zhao, T Jaffer, S Unwith, L Benzonana, Q Lian, A Sakamoto, D Ma
Oncotarget 2016
Senescence Can Be BETter without the SASP?
MG Vizioli, PD Adams
Cancer Discovery 2016
ERK5 Is a Critical Mediator of Inflammation-Driven Cancer
KG Finegan, D Perez-Madrigal, JR Hitchin, CC Davies, AM Jordan, C Tournier
Cancer research 2015
IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells
C Schinke, O Giricz, W Li, A Shastri, S Gordon, L Barreryo, T Bhagat, S Bhattacharyya, N Ramachandra, M Bartenstein, A Pellagatti, J Boultwood, A Wickrema, Y Yu, B Will, S Wei, U Steidl, A Verma
Blood 2015
Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer
H Katoh, M Watanabe
Mediators of Inflammation 2015
NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases: NKT cells and ocular melanoma liver metastases
L Sadegh, PW Chen, JR Brown, Z Han, JY Niederkorn
International Journal of Cancer 2015
The CXCR1/2 Pathway: Involvement in Diabetes Pathophysiology and Potential Target for T1D Interventions
A Citro, E Cantarelli, L Piemonti
Current Diabetes Reports 2015
CXCR2 and CXCL7 expression in liver metastases from colon cancer are correlated to shorter disease-free and overall survival
T Desurmont, N Skrypek, A Duhamel, N Jonckheere, G Millet, E Leteurtre, P Gosset, B Duchene, N Ramdane, M Hebbar, IV Seuningen, FR Pruvot, G Huet, S Truant
Cancer Science 2015
Chemokine Receptor-Specific Antibodies in Cancer Immunotherapy: Achievements and Challenges
M Vela, M Aris, M Llorente, JA Garcia-Sanz, L Kremer
Frontiers in immunology 2015
New achievements in development and application of GPCR-peptides
AO Shpakov, KV Derkach
Journal of Evolutionary Biochemistry and Physiology 2015
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma
CL Wilson, D Jurk, N Fullard, P Banks, A Page, S Luli, AM Elsharkawy, RG Gieling, JB Chakraborty, C Fox, C Richardson, K Callaghan, GE Blair, N Fox, A Lagnado, JF Passos, AJ Moore, GR Smith, DG Tiniakos, J Mann, F Oakley, DA Mann
Nature Communications 2015
Resistance of R-Ras knockout mice to skin tumour induction
U May, S Prince, M Vähätupa, AM Laitinen, K Nieminen, H Uusitalo-Järvinen, TA Järvinen
Scientific Reports 2015
The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
KD Mertz, LF Mager, MH Wasmer, T Thiesler, VH Koelzer, G Ruzzante, S Joller, JR Murdoch, T Brümmendorf, V Genitsch, A Lugli, G Cathomas, H Moch, A Weber, I Zlobec, T Junt, P Krebs
OncoImmunology 2015
Pharmacological antagonism of interleukin-8 receptor CXCR2 inhibits inflammatory reactivity and is neuroprotective in an animal model of Alzheimer’s disease
JK Ryu, T Cho, HB Choi, N Jantaratnotai, JG McLarnon
Journal of Neuroinflammation 2015
The role of tissue resident cells in neutrophil recruitment
ND Kim, AD Luster
Trends in Immunology 2015
Phorbol ester-induced neutrophilic inflammatory responses selectively promote metastatic spread of melanoma in a TLR4-dependent manner
T Bald, J Landsberg, P Jansen, E Gaffal, T Tüting
OncoImmunology 2015
Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer
H Khalili, J Gong, H Brenner, TR Austin, CM Hutter, Y Baba, JA Baron, SI Berndt, S Bézieau, B Caan, PT Campbell, J Chang-Claude, SJ Chanock, C Chen, L Hsu, S Jiao, DV Conti, D Duggan, CS Fuchs, M Gala, S Gallinger, RW Haile, TA Harrison, R Hayes, A Hazra, B Henderson, C Haiman, M Hoffmeister, JL Hopper, MA Jenkins, LN Kolonel, S Küry, A LaCroix, LL Marchand, M Lemire, NM Lindor, J Ma, JA Manson, T Morikawa, H Nan, K Ng, PA Newcomb, R Nishihara, JD Potter, C Qu, RE Schoen, FR Schumacher, D Seminara, D Taverna, S Thibodeau, J Wactawski-Wende, E White, K Wu, BW Zanke, G Casey, TJ Hudson, P Kraft, U Peters, ML Slattery, S Ogino, AT Chan
Carcinogenesis 2015
CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
L Li, L Xu, J Yan, ZJ Zhen, Y Ji, CQ Liu, WY Lau, L Zheng, J Xu
Journal of Experimental & Clinical Cancer Research 2015
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells
A Blaisdell, A Crequer, D Columbus, T Daikoku, K Mittal, SK Dey, A Erlebacher
Cancer Cell 2015
Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc Min/+ mouse model
YS Zhang, Y Li, Y Wang, SY Sun, T Jiang, C Li, SX Cui, XJ Qu
Journal of Cancer Research and Clinical Oncology 2015
Interdicting Gq Activation in Airway Disease by Receptor-Dependent and Receptor-Independent Mechanisms
R Carr, C Koziol-White, J Zhang, H Lam, SS An, GG Tall, RA Panettieri, JL Benovic
Molecular pharmacology 2015
Systematic review and meta-analysis of the prognostic value of CXCR2 in solid tumor patients
Y Yang, B Luo, Y An, H Sun, H Cai, D Sun
Oncotarget 2015
Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis
Zur R, Garcia-Ibanez L, Nunez-Buiza A, Aparicio N, Liappas G, Escós A, Risco A, Page A, Saiz-Ladera C, Alsina-Beauchamp D, Montans J, Paramio JM, Cuenda A
Oncotarget 2015
Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors
Gupta J, Igea A, Papaioannou M, Lopez-Casas PP, Llonch E, Hidalgo M, Gorgoulis VG, Nebreda AR
Oncotarget 2015
CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
M Santoni, S Bracarda, M Nabissi, F Massari, A Conti, E Bria, G Tortora, G Santoni, S Cascinu
BioMed Research International 2014
Host Cxcr2-dependent regulation of mammary tumor growth and metastasis
B Sharma, KC Nannuru, ML Varney, RK Singh
Clinical & Experimental Metastasis 2014
Duality of the Immune Response in Cancer: Lessons Learned from Skin
TR Medler, LM Coussens
Journal of Investigative Dermatology 2014
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment
RV Sionov, ZG Fridlender, Z Granot
Cancer Microenvironment 2014
Giardia duodenalis Infection Reduces Granulocyte Infiltration in an In Vivo Model of Bacterial Toxin-Induced Colitis and Attenuates Inflammation in Human Intestinal Tissue
James A. Cotton, Jean-Paul Motta, L. Patrick Schenck, Simon A. Hirota, Paul L. Beck, Andre G. Buret
PloS one 2014
Live Imaging and Gene Expression Analysis in Zebrafish Identifies a Link between Neutrophils and Epithelial to Mesenchymal Transition
CM Freisinger, A Huttenlocher, O Wever
PloS one 2014
CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development: CXCR2 in Intestinal Tumorigenesis
YS Lee, D Choi, NY Kim, S Yang, E Jung, M Hong, D Yang, HJ Lenz, YK Hong
International Journal of Cancer 2014
Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy
Y Ma, S Adjemian, L Galluzzi, L Zitvogel, G Kroemer
OncoImmunology 2014
The role of neutrophil myeloperoxidase in models of lung tumor development
AL Rymaszewski, E Tate, JP Yimbesalu, AE Gelman, JA Jarzembowski, H Zhang, KA Pritchard, HG Vikis
Cancers 2014
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L )-driven SerpinB2 expression
LK Rushworth, AM Kidger, L Delavaine, G Stewart, S Schelven, J Davidson, CJ Bryant, E Caddye, P East, CJ Caunt, SM Keyse
Proceedings of the National Academy of Sciences 2014
Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2
DY Maeda, AM Peck, AD Schuler, MT Quinn, LN Kirpotina, WN Wicomb, GH Fan, JA Zebala
Journal of Medicinal Chemistry 2014
A Pepducin Derived from the Third Intracellular Loop of FPR2 Is a Partial Agonist for Direct Activation of This Receptor in Neutrophils But a Full Agonist for Cross-Talk Triggered Reactivation of FPR2
M Gabl, M Winther, SL Skovbakke, J Bylund, C Dahlgren, H Forsman, R Seifert
PloS one 2014
The Myc 3' Wnt-Responsive Element Suppresses Colonic Tumorigenesis
WM Konsavage, GS Yochum
Molecular and cellular biology 2014
Identification of a Functional SNP in the 3'UTR of CXCR2 That Is Associated with Reduced Risk of Lung Cancer
BM Ryan, AI Robles, AC McClary, M Haznadar, ED Bowman, SR Pine, D Brown, M Khan, K Shiraishi, T Kohno, H Okayama, R Modali, J Yokota, CC Harris
Cancer research 2014
MyD88 and its divergent toll in carcinogenesis
R Salcedo, C Cataisson, U Hasan, SH Yuspa, G Trinchieri
Trends in Immunology 2013
CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis
H Katoh, D Wang, T Daikoku, H Sun, SK Dey, RN DuBois
Cancer Cell 2013
The Gastrointestinal Tumor Microenvironment
M Quante, J Varga, TC Wang, FR Greten
Gastroenterology 2013
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
LM Campbell, PJ Maxwell, DJ Waugh
Pharmaceuticals (Basel, Switzerland) 2013
CXCR2: a target for pancreatic cancer treatment?
KM Hertzer, GW Donald, OJ Hines
Expert Opinion on Therapeutic Targets 2013
Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish
Q Deng, M Sarris, DA Bennin, JM Green, P Herbomel, A Huttenlocher
Journal of leukocyte biology 2013
Neutrophils in innate and adaptive immunity
S Jaillon, MR Galdiero, DD Prete, MA Cassatella, C Garlanda, A Mantovani
Seminars in Immunopathology 2013
Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis
ME Feigin
FEBS Journal 2013
Alcohol, TLR4-TGF-β antagonism, and liver cancer
H Tsukamoto, L Mishra, K Machida
Hepatology International 2013
TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis
EC Cheung, D Athineos, P Lee, RA Ridgway, W Lambie, C Nixon, D Strathdee, K Blyth, OJ Sansom, KH Vousden
Developmental Cell 2013
Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells
DS Son, SM Kabir, Y Dong, E Lee, SE Adunyah
Journal of Inflammation 2013
CXCR2-driven ovarian cancer progression involves upregulation of proinflammatory chemokines by potentiating NF-κB activation via EGFR-transactivated Akt signaling
YL Dong, SM Kabir, ES Lee, DS Son
PloS one 2013
Structural insights into neutrophilic migration revealed by the crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1
G Lu, Y Wu, Y Jiang, S Wang, Y Hou, X Guan, J Brunzelle, N Sirinupong, S Sheng, C Li, Z Yang
PloS one 2013
Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2
LP Liu, MZ Li, LC Spangler, C Spear, M Veenstra, L Darnall, C Chang, AC Cotleur, RM Ransohoff
Genesis (New York, N.Y. : 2000) 2013

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