Usage Information

Rare serotype adenoviral vectors for HIV vaccine development
Nelson L. Michael
Nelson L. Michael
Published December 27, 2011
Citation Information: J Clin Invest. 2012;122(1):25-27. https://doi.org/10.1172/JCI60988.
View: Text | PDF
Commentary Article has an altmetric score of 1

Rare serotype adenoviral vectors for HIV vaccine development

Abstract

Human adenoviral vectors are being developed for use in candidate vaccines for HIV-1 and other pathogens. However, this approach suffered a setback when an HIV-1 vaccine using an adenovirus type 5 (Ad5) vector failed to reduce, and might even have increased, the rate of HIV infection in men who were uncircumcised and who had preexisting antibodies specific for Ad5. This increased interest in the evaluation of serologically distinct adenoviral vectors. In this issue of the JCI, Frahm and coworkers report evidence that preexisting cellular immune responses directed toward Ad5 reduce the immunogenicity of antigens expressed in Ad5-vectored vaccines and have cross-reacting potential with non-Ad5 adenoviral vectors. The implications of this observation need to be carefully evaluated in future clinical trials of all serotypes of adenovirus-vectored vaccines.

Authors

Nelson L. Michael

×

Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 251 13
PDF 70 11
Figure 43 0
Citation downloads 44 0
Totals 408 24
Total Views 432
(Click and drag on plot area to zoom in. Click legend items above to toggle)

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement