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Santiago Zelenay, … , David Sancho, Caetano Reis e Sousa
Published April 16, 2012
Citation Information: J Clin Invest. 2012;122(5):1615-1627. https://doi.org/10.1172/JCI60644.
Citation Information: J Clin Invest. 2012;122(5):1615-1627. https://doi.org/10.1172/JCI60644.
Abstract
DNGR-1 (CLEC9A) is a receptor for necrotic cells required by DCs to cross-prime CTLs against dead cell antigens in mice. It is currently unknown how DNGR-1 couples dead cell recognition to cross-priming. Here we found that DNGR-1 did not mediate DC activation by dead cells but rather diverted necrotic cell cargo into a recycling endosomal compartment, favoring cross-presentation to CD8+ T cells. DNGR-1 regulated cross-priming in non-infectious settings such as immunization with antigen-bearing dead cells, as well as in highly immunogenic situations such as infection with herpes simplex virus type 1. Together, these results suggest that DNGR-1 is a dedicated receptor for cross-presentation of cell-associated antigens. Our work thus underscores the importance of cross-priming in immunity and indicates that antigenicity and adjuvanticity can be decoded by distinct innate immune receptors. The identification of specialized receptors that regulate antigenicity of virus-infected cells reveals determinants of antiviral immunity that might underlie the human response to infection and vaccination.
Authors
Santiago Zelenay, Anna M. Keller, Paul G. Whitney, Barbara U. Schraml, Safia Deddouche, Neil C. Rogers, Oliver Schulz, David Sancho, Caetano Reis e Sousa
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Frontiers in immunology | 2015 |
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Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid
R Zeng, M Bscheider, K Lahl, M Lee, EC Butcher |
Mucosal Immunology | 2015 |
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Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs
B Grubor-Bauk, W Yu, D Wijesundara, J Gummow, T Garrod, AJ Brennan, I Voskoboinik, EJ Gowans |
Gene Therapy | 2015 |
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C-type lectins in immunity: recent developments
IM Dambuza, GD Brown |
Current Opinion in Immunology | 2015 |
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T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R
M Goritzka, C Pereira, S Makris, LR Durant, C Johansson |
Scientific Reports | 2015 |
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Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy
Y Wan, B Simovic, S Walsh |
Oncolytic Virotherapy | 2015 |
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An Axl-LRP-1-RanBP9 Complex Mediates Dendritic Cell Efferocytosis and Antigen Cross-Presentation
Manikandan Subramanian, Crystal Hayes, Joseph Thome, Edward Thorp, Glenn Matsushima, Joachim Herz, Donna Farber, Kang Liu, Madepalli Lakshmana, Ira Tabas |
Journal of Clinical Investigation | 2014 |
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Shotgun proteomics: Identification of unique protein profiles of apoptotic bodies from biliary epithelial cells: LLEO ET AL
A Lleo, W Zhang, WH McDonald, EH Seeley, PS Leung, RL Coppel, AA Ansari, DH Adams, S Afford, P Invernizzi, ME Gershwin |
Hepatology | 2014 |
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C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens
L Baudino, A Sardini, MM Ruseva, L Fossati-Jimack, HT Cook, D Scott, E Simpson, M Botto |
Proceedings of the National Academy of Sciences | 2014 |
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Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas: Cellular immune response
G Picco, R Beatson, J Taylor-Papadimitriou, JM Burchell |
European Journal of Immunology | 2014 |
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Harnessing Human Cross-Presenting CLEC9A(+)XCR1(+) Dendritic Cells for Immunotherapy
KM Tullett, MH Lahoud, KJ Radford |
Frontiers in immunology | 2014 |
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Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors
S Iborra, D Sancho |
Immunobiology | 2014 |
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Current Topics in Microbiology and Immunology
MM Hufford, TS Kim, J Sun, TJ Braciale |
Current topics in microbiology and immunology | 2014 |
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Dendritic Cell-Targeted Vaccines
L Cohn, LÃ Delamarre |
Frontiers in immunology | 2014 |
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Understanding MHC Class I Presentation of Viral Antigens by Human Dendritic Cells as a Basis for Rational Design of Therapeutic Vaccines
N Montfoort, E der Aa, AM Woltman |
Frontiers in immunology | 2014 |
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Increase in DNA vaccine efficacy by virosome delivery and co-expression of a cytolytic protein
T Gargett, B Grubor-Bauk, D Miller, T Garrod, S Yu, S Wesselingh, A Suhrbier, EJ Gowans |
IBMS BoneKEy | 2014 |
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Complementary diversification of dendritic cells and innate lymphoid cells
CG Briseño, TL Murphy, KM Murphy |
Current Opinion in Immunology | 2014 |
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The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells
F Osorio, SJ Tavernier, E Hoffmann, Y Saeys, L Martens, J Vetters, I Delrue, RD Rycke, E Parthoens, P Pouliot, T Iwawaki, S Janssens, BN Lambrecht |
Nature Immunology | 2014 |
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Signalling C-type lectin receptors, microbial recognition and immunity
JC Hoving, GJ Wilson, GD Brown |
Cellular Microbiology | 2014 |
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Going viral with cancer immunotherapy
BD Lichty, CJ Breitbach, DF Stojdl, JC Bell |
Nature Reviews Cancer | 2014 |
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Redirecting soluble antigen for MHC class I cross-presentation during phagocytosis: Antigen processing
A Hari, A Ganguly, L Mu, SP Davis, MD Stenner, R Lam, F Munro, I Namet, E Alghamdi, T Fürstenhaupt, W Dong, P Detampel, LJ Shen, MW Amrein, RM Yates, Y Shi |
European Journal of Immunology | 2014 |
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T-cell immunity to human alphaherpesviruses
WJ Ouwendijk, KJ Laing, GM Verjans, DM Koelle |
Current Opinion in Virology | 2013 |
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A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2
R Murakami, K Denda-Nagai, S Hashimoto, S Nagai, M Hattori, T Irimura, G Kassiotis |
PloS one | 2013 |
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Molecular Control of Steady-State Dendritic Cell Maturation and Immune Homeostasis
GE Hammer, A Ma |
Annual Review of Immunology | 2013 |
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Rational combinations of immunotherapeutics that target discrete pathways
S Spranger, T Gajewski |
Journal for ImmunoTherapy of Cancer | 2013 |
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Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation
L Cohn, B Chatterjee, F Esselborn, A Smed-Sorensen, N Nakamura, C Chalouni, BC Lee, R Vandlen, T Keler, P Lauer, D Brockstedt, I Mellman, L Delamarre |
Journal of Experimental Medicine | 2013 |
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Innate and adaptive immune cells in the tumor microenvironment
TF Gajewski, H Schreiber, YX Fu |
Nature Immunology | 2013 |
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Targeting Antigens to Dendritic Cell Receptors for Vaccine Development
V Apostolopoulos, T Thalhammer, AG Tzakos, L Stojanovska |
Journal of drug delivery | 2013 |
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Sensing of cell death by myeloid C-type lectin receptors
D Sancho, CR Sousa |
Current Opinion in Immunology | 2013 |
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C-Type Lectin-Like Receptors of the Dectin-1 Cluster: Ligands and Signaling Pathways
A Plato, JA Willment, GD Brown |
International Reviews of Immunology | 2013 |
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Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ-resident dendritic cells
E Segura, M Durand, S Amigorena |
Journal of Experimental Medicine | 2013 |
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Antitumor immune responses mediated by dendritic cells
L Spel, JJ Boelens, S Nierkens, M Boes |
OncoImmunology | 2013 |
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Differentiation and activation of equine monocyte-derived dendritic cells are not correlated with CD206 or CD83 expression
NA Moyo, E Marchi, F Steinbach |
Immunology | 2013 |
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An updated view of the intracellular mechanisms regulating cross-presentation
P Nair-Gupta, JM Blander |
Frontiers in immunology | 2013 |
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Signalling C-type lectins in antimicrobial immunity
RA Drummond, GD Brown |
PLoS pathogens | 2013 |
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A DC receptor for damaged cells mediates cross-priming of CTL during vaccinia virus infection in mice
Salvador Iborra, Helena M. Izquierdo, María Martínez-López, Noelia Blanco-Menéndez, Caetano Reis e Sousa, David Sancho |
Journal of Clinical Investigation | 2012 |
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Dying cell clearance and its impact on the outcome of tumor radiotherapy
K Lauber, A Ernst, M Orth, M Herrmann, C Belka |
Frontiers in Oncology | 2012 |
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Increasing the efficacy of tumor cell vaccines by enhancing cross priming
BM Andersen, JR Ohlfest |
Cancer Letters | 2012 |
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Re(de)fining the dendritic cell lineage
AT Satpathy, X Wu, JC Albring, KM Murphy |
Nature Immunology | 2012 |
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Presentation of phagocytosed antigens by MHC class I and II
AR Mantegazza, JG Magalhaes, S Amigorena, MS Marks |
Traffic (Copenhagen, Denmark) | 2012 |
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Type I interferon response and innate immune sensing of cancer
MB Fuertes, SR Woo, B Burnett, YX Fu, TF Gajewski |
Trends in Immunology | 2012 |
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Actin a dangerous part
Y Bordon |
Nature Reviews Immunology | 2012 |
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Actin' dangerously
GD Brown |
Nature | 2012 |
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