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Viruses and human brain tumors: cytomegalovirus enters the fray
Cynthia Hawkins, Sidney Croul
Cynthia Hawkins, Sidney Croul
Published September 26, 2011
Citation Information: J Clin Invest. 2011;121(10):3831-3833. https://doi.org/10.1172/JCI60005.
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Commentary Article has an altmetric score of 4

Viruses and human brain tumors: cytomegalovirus enters the fray

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Abstract

Medulloblastoma is the most common malignant brain tumor in children. Overall survival rates have improved in recent years as a result of risk-stratified treatment regimens. However, medulloblastoma remains associated with substantial mortality, and survivors often experience debilitating neurological, endocrinological, and social sequelae as a result of treatment. Targeted and less toxic therapeutic strategies are therefore needed. In this issue of the JCI, Baryawno et al. report their findings that a large percentage of primary medulloblastomas and medulloblastoma cell lines are infected with human cytomegalovirus (HCMV) and suggest that targeting this virus could provide a new way to treat individuals with medulloblastoma.

Authors

Cynthia Hawkins, Sidney Croul

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