Peripheral nerves are easily damaged, resulting in loss of motor and sensory function. Recovery of motor and sensory function after peripheral nerve injury is suboptimal, even after appropriate surgical repair. This is due to the slow rate of axonal elongation during regeneration and atrophic changes that occur in denervated Schwann cells and target muscle with proximal lesions. One way to solve this problem is to accelerate the rate at which the axons regenerate. In this issue of the JCI, Ma and colleagues show that this can be achieved in mice by overexpression of heat shock protein 27, providing hope for enhanced functional recovery in patients after peripheral nerve damage.
Ahmet Höke
Title and authors | Publication | Year |
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Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury.
Mehrotra P, Jablonski J, Toftegard J, Zhang Y, Shahini S, Wang J, Hung CW, Ellis R, Kayal G, Rajabian N, Liu S, Roballo K, Udin SB, Andreadis ST, Personius KE |
Research square | 2024 |
Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury
Mehrotra P, Jablonski J, Toftegaard J, Zhang Y, Shahini S, Wang J, Hung CW, Ellis R, Kayal G, Rajabian N, Liu S, Roballo KC, Udin SB, Andreadis ST, Personius KE |
Nature Communications | 2024 |
Scaffold design considerations for peripheral nerve regeneration
Yu L, Bennett CJ, Lin CH, Yan S, Yang J |
Journal of neural engineering | 2024 |
Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review
Ronchi G, Fregnan F, Muratori L, Gambarotta G, Raimondo S |
International journal of molecular sciences | 2023 |
Impact of Heat Shock Proteins in Neurodegeneration: Possible Therapeutical Targets
Beretta G, Shala AL |
Annals of Neurosciences | 2022 |
Axonal Regeneration: Underlying Molecular Mechanisms and Potential Therapeutic Targets
Akram R, Anwar H, Javed MS, Rasul A, Imran A, Malik SA, Raza C, Khan IU, Sajid F, Iman T, Sun T, Han HS, Hussain G |
Biomedicines | 2022 |
Interaction between Schwann cells and other cells during repair of peripheral nerve injury
WR Qu, Z Zhu, J Liu, DB Song, H Tian, BP Chen, R Li, LX Deng |
NEURAL REGEN RES | 2021 |
Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects
A Crosio, BE Fornasari, G Gambarotta, S Geuna, S Raimondo, B Battiston, P Tos, G Ronchi |
NEURAL REGEN RES | 2019 |
Glial Cell Line–Derived Neurotrophic Factor and Chondroitinase Promote Axonal Regeneration in a Chronic Denervation Animal Model
KA Sarhane, SH Tuffaha, Z Ibrahim, CR Cashman, K Krick, R Martin, JM Broyles, DS Cooney, WP Lee, R Mi, HQ Mao, A Höke, G Brandacher |
Neurotherapeutics | 2019 |
Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit
MM Saller, RE Huettl, JM Mayer, A Feuchtinger, C Krug, T Holzbach, E Volkmer |
NEURAL REGEN RES | 2018 |
Beta secretase activity in peripheral nerve regeneration
C Tallon, MH Farah |
NEURAL REGEN RES | 2017 |
Transgenic SCs expressing GDNF-IRES-DsRed impair nerve regeneration within acellular nerve allografts: Transgenic SCs Expressing GDNF
X Ee, Y Yan, DA Hunter, L Schellhardt, SE Sakiyama-Elbert, SE Mackinnon, MD Wood |
Biotechnology and Bioengineering | 2017 |
Chronically denervated distal nerve stump inhibits peripheral nerve regeneration
G Ronchi, S Raimondo |
NEURAL REGEN RES | 2017 |
Allotransplanted DRG neurons or Schwann cells affect functional recovery in a rodent model of sciatic nerve injury
S Dayawansa, EW Wang, W Liu, JD Markman, HA Gelbard, JH Huang |
Neurological Research | 2014 |
Advances in peripheral nerve regeneration
J Scheib, A Höke |
Nature Reviews Neurology | 2013 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |