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Citations to this article

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
Philippe Ravassard, … , Paul Czernichow, Raphael Scharfmann
Philippe Ravassard, … , Paul Czernichow, Raphael Scharfmann
Published August 25, 2011
Citation Information: J Clin Invest. 2011;121(9):3589-3597. https://doi.org/10.1172/JCI58447.
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Technical Advance Article has an altmetric score of 12

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

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Abstract

Despite intense efforts over the past 30 years, human pancreatic β cell lines have not been available. Here, we describe a robust technology for producing a functional human β cell line using targeted oncogenesis in human fetal tissue. Human fetal pancreatic buds were transduced with a lentiviral vector that expressed SV40LT under the control of the insulin promoter. The transduced buds were then grafted into SCID mice so that they could develop into mature pancreatic tissue. Upon differentiation, the newly formed SV40LT-expressing β cells proliferated and formed insulinomas. The resulting β cells were then transduced with human telomerase reverse transcriptase (hTERT), grafted into other SCID mice, and finally expanded in vitro to generate cell lines. One of these cell lines, EndoC-βH1, expressed many β cell–specific markers without any substantial expression of markers of other pancreatic cell types. The cells secreted insulin when stimulated by glucose or other insulin secretagogues, and cell transplantation reversed chemically induced diabetes in mice. These cells represent a unique tool for large-scale drug discovery and provide a preclinical model for cell replacement therapy in diabetes. This technology could be generalized to generate other human cell lines when the cell type–specific promoter is available.

Authors

Philippe Ravassard, Yasmine Hazhouz, Séverine Pechberty, Emilie Bricout-Neveu, Mathieu Armanet, Paul Czernichow, Raphael Scharfmann

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Diabetes 2022
Islet Gene View - a tool to facilitate islet research
Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi Prasad
Life science alliance 2022
Stem Cell-Derived Islets for Type 2 Diabetes
A Salib, F Cayabyab, E Yoshihara
International journal of molecular sciences 2022
Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction
A Bartolomé
International journal of molecular sciences 2022
The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions
M Brown, D Laouteouet, M Delobel, O Villard, C Broca, G Bertrand, A Wojtusciszyn, S Dalle, M Ravier, A Matveyenko, S Costes
Cell Death and Disease 2022
Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
E Shcheglova, K Blaszczyk, M Borowiak
Frontiers in Cell and Developmental Biology 2022
Characterization of the Secretome, Transcriptome, and Proteome of Human β Cell Line EndoC-βH1
M Ryaboshapkina, K Saitoski, G Hamza, A Jarnuczak, S Pechberty, C Berthault, K Sengupta, C Underwood, S Andersson, R Scharfmann
Molecular & cellular proteomics : MCP 2022
Quantification of Unmethylated Insulin DNA Using Methylation Sensitive Restriction Enzyme Digital Polymerase Chain Reaction
F van de Leemkolk, R Nell, M Versluis, E de Koning, V Huurman, I Alwayn, R Ploeg, P van der Velden, M Engelse
Transplant international : official journal of the European Society for Organ Transplantation 2022
High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets
H MacMillan, Y Kong, E Calvo-Roitberg, L Alonso, A Pai
Scientific Reports 2022
NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes
P Xiao, T Takiishi, N Violato, G Licata, F Dotta, G Sebastiani, L Marselli, S Singh, M Sze, G Loo, E Dejardin, E Gurzov, A Cardozo
Cell Death and Disease 2022
Loss of Human Beta Cell Identity in a Reconstructed Omental Stromal Cell Environment
B Secco, K Saitoski, K Drareni, A Soprani, S Pechberty, L Rachdi, N Venteclef, R Scharfmann
Cells 2022
Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic β-Cells: Evaluation of Murine and Human In Vitro Models
R Al-Abdulla, H Ferrero, S Soriano, T Boronat-Belda, P Alonso-Magdalena
International journal of molecular sciences 2022
In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model
R Santos, R Medina-Gali, I Babiloni-Chust, L Marroqui, A Nadal
International journal of molecular sciences 2022
Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells
Dettmer R, Niwolik I, Cirksena K, Yoshimoto T, Tang Y, Mehmeti I, Gurgul-Convey E, Naujok O
Diabetologia 2022
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan A, Spracklen CN, Zhang W, Ng MC, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Parolo PD, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJ, Tam CH, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JC, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam T, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen ME, Jørgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schönherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stančáková A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YD, Froguel P, Wilson JG, Sheu WH, Kardia SL, Wu JY, Hayes MG, Ma RC, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Palmer CN, Liu S, Abecasis G, Kooner JS, Loos RJ, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Mägi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris AP
Nature Genetics 2022
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
Golec E, Ekström A, Noga M, Omar-Hmeadi M, Lund PE, Villoutreix BO, Krus U, Wozniak K, Korsgren O, Renström E, Barg S, King BC, Blom AM
Proceedings of the National Academy of Sciences 2022
ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells.
Hagenlocher C, Siebert R, Taschke B, Wieske S, Hausser A, Rehm M
Cell Death Discovery 2022
DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism
Chatterjee Bhowmick D, Aslamy A, Bhattacharya S, Oh E, Ahn M, Thurmond DC
Diabetes 2022
Temporal regulation of interferon signalling in human EndoC-βH1 cells
Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG
Journal of molecular endocrinology 2022
Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells
Noordstra I, van den Berg CM, Boot FW, Katrukha EA, Yu KL, Tas RP, Portegies S, Viergever BJ, de Graaff E, Hoogenraad CC, de Koning EJ, Carlotti F, Kapitein LC, Akhmanova A
Journal of cell science 2022
Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion
Szczerbinska I, Tessitore A, Hansson LK, Agrawal A, Ragel Lopez A, Helenius M, Malinowski AR, Gilboa B, Ruby MA, Gupta R, Ämmälä C
Biomedicines 2022
Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells
Thomas P, Arden C, Corcoran J, Hacker C, Welters HJ, Morgan NG
Nutrition & Diabetes 2022
Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits
Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R
The Journal of biological chemistry 2022
Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation
Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F
Cell Death Discovery 2022
The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function
Davidson RK, Weaver SA, Casey N, Kanojia S, Hogarth E, Aguirre RS, Sims EK, Evans-Molina C, Spaeth JM
Journal of molecular endocrinology 2022
Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
Moon S, Jung HS
Diabetes & Metabolism Journal 2022
Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells
Bulfoni M, Bouyioukos C, Zakaria A, Nigon F, Rapone R, Del Maestro L, Ait-Si-Ali S, Scharfmann R, Cosson B
Frontiers in Endocrinology 2022
In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo
Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M
Frontiers in Cell and Developmental Biology 2022
Treating iPSC-Derived β Cells with an Anti-CD30 Antibody-Drug Conjugate Eliminates the Risk of Teratoma Development upon Transplantation.
Pellegrini S, Zamarian V, Landi E, Cospito A, Lombardo MT, Manenti F, Citro A, Schiavo Lena M, Piemonti L, Sordi V
International journal of molecular sciences 2022
ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis
Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A
Frontiers in Endocrinology 2022
Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.
Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL
Science Advances 2022
The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse β-Cells
Martins Peçanha FL, Jaafar R, Werneck-de-Castro JP, Apostolopolou CC, Bhushan A, Bernal-Mizrachi E
Diabetes 2022
The highly expressed calcium‐insensitive synaptotagmin‐11 and synaptotagmin‐13 modulate insulin secretion
Ofori JK, Karagiannopoulos A, Barghouth M, Nagao M, Andersson ME, Salunkhe VA, Zhang E, Wendt A, Eliasson L
Acta physiologica (Oxford, England) 2022
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.
Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F
Non-Coding RNA 2022
Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies.
Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL
iScience 2022
The human batokine EPDR1 regulates β-cell metabolism and function
Cataldo LR, Gao Q, Argemi-Muntadas L, Hodek O, Cowan E, Hladkou S, Gheibi S, Spégel P, Prasad RB, Eliasson L, Scheele C, Fex M, Mulder H, Moritz T
Molecular Metabolism 2022
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding
Alghamdi TA, Krentz NA, Smith N, Spigelman AF, Rajesh V, Jha A, Ferdaoussi M, Suzuki K, Yang J, Manning Fox JE, Sun H, Sun Z, Gloyn AL, MacDonald PE
Molecular Metabolism 2022
Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.
Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL
Diabetologia 2022
ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A
Frontiers in Endocrinology 2022
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.
Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL
Nature Genetics 2022
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Guo Z, Kasinathan D, Merriman C, Nakayama M, Li H, Li H, Xu C, Wong GW, Yu L, Golson ML, Fu D
Diabetes 2022
Experimental Approaches to Diabetes Mellitus
Yayla M, Binnetoğlu D
The Eurasian Journal of Medicine 2022
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression
L Regué, L Zhao, F Ji, H Wang, J Avruch, N Dai
Molecular Metabolism 2021
Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress
N Groen, F Leenders, A Mahfouz, A Munoz-Garcia, MJ Muraro, N de Graaf, TJ Rabelink, R Hoeben, A van Oudenaarden, A Zaldumbide, MJ Reinders, EJ de Koning, F Carlotti
Cells 2021
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
M Hu, I Cebola, G Carrat, S Jiang, S Nawaz, A Khamis, M Canouil, P Froguel, A Schulte, M Solimena, M Ibberson, P Marchetti, FL Cardenas-Diaz, PJ Gadue, B Hastoy, L Alemeida-Souza, H McMahon, GA Rutter
Cell Reports 2021
The Human Islet: Mini-Organ With Mega-Impact
JT Walker, DC Saunders, M Brissova, AC Powers
Endocrine reviews 2021
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells
BS Low, CS Lim, SS Ding, YS Tan, NH Ng, VG Krishnan, SF Ang, CW Neo, CS Verma, S Hoon, SC Lim, ES Tai, AK Teo
Nature Communications 2021
Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies
A Mooranian, M Jones, CM Ionescu, D Walker, SR Wagle, B Kovacevic, J Chester, T Foster, E Johnston, M Mikov, H Al-Salami
Nanomaterials 2021
Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity
F Leenders, N Groen, N de Graaf, MA Engelse, TJ Rabelink, EJ de Koning, F Carlotti
Frontiers in immunology 2021
Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative
M de Fátima Brito, C Torre, B Silva-Lima
Frontiers in Medicine 2021
The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis
M Ramos-Rodríguez, B Pérez-González, L Pasquali
Current Diabetes Reports 2021
Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death
P Thomas, KA Leslie, HJ Welters, NG Morgan
Nutrition & Metabolism 2021
Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells
EM MacFarlane, JE Bruin
Frontiers in Endocrinology 2021
Regulation of ATR-dependent DNA damage response by nitric oxide
CT Yeo, JS Stancill, BJ Oleson, JK Schnuck, JD Stafford, A Naatz, PA Hansen, JA Corbett
The Journal of biological chemistry 2021
CD81 marks immature and dedifferentiated pancreatic β-cells
C Salinno, M Büttner, P Cota, S Tritschler, M Tarquis-Medina, A Bastidas-Ponce, K Scheibner, I Burtscher, A Böttcher, FJ Theis, M Bakhti, H Lickert
Molecular Metabolism 2021
Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ
R Veluthakal, E Oh, M Ahn, DC Bhowmick, DC Thurmond
Diabetes 2021
Human Pluripotent Stem Cells to Model Islet Defects in Diabetes
D Balboa, DG Iworima, TJ Kieffer
Frontiers in Endocrinology 2021
Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
AC de Brachène, A Castela, AE Musuaya, L Marselli, P Marchetti, DL Eizirik
Autoimmunity Highlights 2021
Insulinoma-derived pseudo-islets for diabetes research
NJ Hart, C Weber, N Price, A Banuelos, M Schultz, B Huey, E Harnois, C Gibson, LV Steyn, KK Papas, RM Lynch
American journal of physiology. Cell physiology 2021
Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
X Jian, G Felsenfeld
Nature Communications 2021
ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
X Wang, S Younis, J Cen, Y Wang, C Krizhanovskii, L Andersson, N Welsh
Diabetologia 2021
Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection
JR Chaffey, J Young, KA Leslie, K Partridge, P Akhbari, S Dhayal, JL Hill, KC Wedgwood, E Burnett, MA Russell, SJ Richardson, NG Morgan
Scientific Reports 2021
Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
Y Tang, T Plötz, MH Gräler, E Gurgul-Convey
International journal of molecular sciences 2021
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion
N Vishnu, A Hamilton, A Bagge, A Wernersson, E Cowan, H Barnard, Y Sancak, KJ Kamer, P Spégel, M Fex, A Tengholm, VK Mootha, DG Nicholls, H Mulder
Molecular Metabolism 2021
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
H Lin, Y Yan, Y Luo, WY So, X Wei, X Zhang, X Yang, J Zhang, Y Su, X Yang, B Zhang, K Zhang, N Jiang, BK Chow, W Han, F Wang, F Rao
Nature Communications 2021
A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis
MI Alvelos, F Szymczak, Â Castela, S Marín-Cañas, BM de Souza, I Gkantounas, M Colli, F Fantuzzi, C Cosentino, M Igoillo-Esteve, L Marselli, P Marchetti, M Cnop, DL Eizirik
Islets 2021
Found in Translation: Novel Insights Into Type 1 Diabetes and β-Cell Biology
HA Russ, HW Davidson
Diabetes 2021
Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion
A Zakaria, C Berthault, B Cosson, V Jung, IC Guerrera, L Rachdi, R Scharfmann
The Journal of biological chemistry 2021
Butyrate Protects Pancreatic Beta Cells from Cytokine-Induced Dysfunction
M Prause, SS Pedersen, V Tsonkova, M Qiao, N Billestrup
International journal of molecular sciences 2021
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
SN Gharavy, BM Owen, SJ Millership, P Chabosseau, G Pizza, A Martinez-Sanchez, E Tasoez, E Georgiadou, M Hu, NH Fine, DA Jacobson, MT Dickerson, O Idevall-Hagren, A Montoya, H Kramer, Z Mehta, DJ Withers, N Ninov, PJ Gadue, FL Cardenas-Diaz, C Cruciani-Guglielmacci, C Magnan, M Ibberson, I Leclerc, M Voz, GA Rutter
Diabetologia 2021
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans
AR Sánchez-Archidona, C Cruciani-Guglielmacci, C Roujeau, L Wigger, J Lallement, J Denom, M Barovic, N Kassis, F Mehl, J Weitz, M Distler, C Klose, K Simons, M Ibberson, M Solimena, C Magnan, B Thorens
Molecular Metabolism 2021
Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice
S Erener, CE Ellis, A Ramzy, MM Glavas, S ODwyer, S Pereira, T Wang, J Pang, JE Bruin, MJ Riedel, RK Baker, TD Webber, M Lesina, M Blüher, H Algül, JL Kopp, S Herzig, TJ Kieffer
Cell reports. Medicine 2021
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells
S Kahraman, D Manna, E Dirice, B Maji, J Small, BK Wagner, A Choudhary, RN Kulkarni
Life science alliance 2021
Reagents and models for detecting endogenous GLP1R and GIPR
J Ast, J Broichhagen, DJ Hodson
EBioMedicine 2021
Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
A Mooranian, M Jones, CM Ionescu, D Walker, SR Wagle, B Kovacevic, J Chester, T Foster, E Johnston, J Kuthubutheen, D Brown, M Mikov, H Al-Salami
Journal of Functional Biomaterials 2021
Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Elksnis A, Cen J, Wikström P, Carlsson PO, Welsh N
Biomedicines 2021
Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Ofori JK, Karagiannopoulos A, Nagao M, Westholm E, Ramadan S, Wendt A, Esguerra JL, Eliasson L
Diabetes 2021
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress
Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew Wakeling, Federica Fantuzzi, Kashyap A. Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas Laver, Matthew B Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Ozbek, Edip Unal, Ruken Yıldırım, Tushar Godbole, Melek Yildiz, Banu Aydin, Angeline Bilheu, Ikuo K. Suzuki, Sarah E Flanagan, Pierre Vanderhaeghen, Valérie Senée, Cécile Julier, Piero Marchetti, Decio L. Eizirik, Sian Ellard, Jonna Saarimäki-Vire, Timo Otonkoski, Miriam Cnop, Andrew T. Hattersley
Journal of Clinical Investigation 2020
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Mariana Igoillo-Esteve, Ana F Oliveira, Cristina Cosentino, Federica Fantuzzi, Céline Demarez, Sanna Toivonen, Amélie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, Decio Eizirik, Miriam Cnop
JCI Insight 2020
Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets
L Rachdi, A Maugein, S Pechberty, M Armanet, J Hamroune, P Ravassard, S Marullo, O Albagli, R Scharfmann
Scientific Reports 2020
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis
GR Carrat, E Haythorne, A Tomas, L Haataja, A Müller, P Arvan, A Piunti, K Cheng, M Huang, TJ Pullen, E Georgiadou, T Stylianides, NS Amirruddin, V Salem, W Distaso, A Cakebread, KJ Heesom, PA Lewis, DJ Hodson, LJ Briant, AC Fung, RB Sessions, F Alpy, AP Kong, PI Benke, F Torta, AK Teo, I Leclerc, M Solimena, DB Wigley, GA Rutter
Molecular Metabolism 2020
Aberrant methylation underlies insulin gene expression in human insulinoma
E Karakose, H Wang, W Inabnet, RV Thakker, S Libutti, G Fernandez-Ranvier, H Suh, M Stevenson, Y Kinoshita, M Donovan, Y Antipin, Y Li, X Liu, F Jin, P Wang, A Uzilov, C Argmann, EE Schadt, AF Stewart, DK Scott, L Lambertini
Nature Communications 2020
Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival
R Hu, E Walker, C Huang, Y Xu, C Weng, GE Erickson, A Coldren, X Yang, M Brissova, I Kaverina, BN Appakalai, CV Wright, Y Li, R Stein, G Gu
Developmental Cell 2020
Modeling different types of diabetes using human pluripotent stem cells
EM Abdelalim
Cellular and Molecular Life Sciences 2020
Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
ES Nakayasu, F Syed, SA Tersey, MA Gritsenko, HD Mitchell, CY Chan, E Dirice, JV Turatsinze, Y Cui, RN Kulkarni, DL Eizirik, WJ Qian, BJ Webb-Robertson, C Evans-Molina, RG Mirmira., TO Metz
Cell Metabolism 2020
A Dual Reporter EndoC-βH1 Human β-Cell Line for Efficient Quantification of Calcium Flux and Insulin Secretion
FL Cardenas-Diaz, KF Leavens, S Kishore, C Osorio-Quintero, YJ Chen, BZ Stanger, P Wang, D French, P Gadue
Endocrinology 2020
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
NA Krentz, AL Gloyn
Nature Reviews Endocrinology 2020
Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
JL Esguerra, JK Ofori, M Nagao, Y Shuto, A Karagiannopoulos, J Fadista, H Sugihara, L Groop, L Eliasson
Molecular Metabolism 2020
Toxicity of fatty acid profiles of popular edible oils in human EndoC-βH1 beta-cells
AS von Hanstein, S Lenzen, T Plötz
Nutrition and Diabetes 2020
Establishment of A Reversibly Inducible Porcine Granulosa Cell Line
Y Bai, C Zhu, M Feng, B Pan, S Zhang, X Zhan, H Chen, B Wang, J Li
Cells 2020
Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
M Nagao, JL Esguerra, A Asai, JK Ofori, A Edlund, A Wendt, H Sugihara, CB Wollheim, S Oikawa, L Eliasson
Diabetes 2020
Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project
K Audouze, D Sarigiannis, P Alonso-Magdalena, C Brochot, M Casas, M Vrijheid, PJ Babin, S Karakitsios, X Coumoul, R Barouki
International journal of molecular sciences 2020
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes
AC de Brachène, A Castela, AO de Beeck, RG Mirmira, L Marselli, P Marchetti, C Masse, W Miao, S Leit, C EvansMolina, DL Eizirik
Diabetes, obesity & metabolism 2020
Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals
A Wesolowska-Andersen, GZ Yu, V Nylander, F Abaitua, M Thurner, JM Torres, A Mahajan, AL Gloyn, MI McCarthy
eLife 2020
MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling
H Mziaut, G Henniger, K Ganss, S Hempel, S Wolk, J McChord, K Chowdhury, P Ravassard, KP Knoch, C Krautz, J Weitz, R Grützmann, C Pilarsky, M Solimena, S Kersting
Molecular Metabolism 2020
Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells
F Xu, J Liu, L Na, L Chen
Frontiers in Cell and Developmental Biology 2020
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells
C Berthault, W Staels, R Scharfmann
Molecular Metabolism 2020
A Toolbox for Translational Research on Beta Cell Function
T Schulze, I Rustenbeck
Endocrinology 2020
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
A Viñuela, A Varshney, M van de Bunt, RB Prasad, O Asplund, A Bennett, M Boehnke, AA Brown, MR Erdos, J Fadista, O Hansson, G Hatem, C Howald, AK Iyengar, P Johnson, U Krus, PE MacDonald, A Mahajan, JE Fox, N Narisu, V Nylander, P Orchard, N Oskolkov, NI Panousis, A Payne, ML Stitzel, S Vadlamudi, R Welch, FS Collins, KL Mohlke, AL Gloyn, LJ Scott, ET Dermitzakis, L Groop, SC Parker, MI McCarthy
Nature Communications 2020
Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells
E Gurgul-Convey
Cells 2020
Effects of Polyphenols on Insulin Resistance
G Williamson, K Sheedy
Nutrients 2020
Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress
T Ishibashi, S Morita, S Kishimoto, S Uraki, K Takeshima, Y Furukawa, H Inaba, H Ariyasu, H Iwakura, H Furuta, M Nishi, FR Papa, T Akamizu
Journal of Diabetes Investigation 2020
Production and Characterization of a Conditionally Immortalized Dog Beta-Cell Line from Fetal Canine Pancreas
P Czernichow, K Reynaud, P Ravassard
Cell Transplantation 2020
A requirement for pak1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis
M Ahn, E Oh, EM McCown, X Wang, R Veluthakal, DC Thurmond
Metabolism 2020
SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature
D Fignani, G Licata, N Brusco, L Nigi, GE Grieco, L Marselli, L Overbergh, C Gysemans, ML Colli, P Marchetti, C Mathieu, DL Eizirik, G Sebastiani, F Dotta
Frontiers in Endocrinology 2020
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
ML Colli, M Ramos-Rodríguez, ES Nakayasu, MI Alvelos, M Lopes, JL Hill, JV Turatsinze, AC de Brachène, MA Russell, H Raurell-Vila, A Castela, J Juan-Mateu, BJ Webb-Robertson, L Krogvold, K Dahl-Jorgensen, L Marselli, P Marchetti, SJ Richardson, NG Morgan, TO Metz, L Pasquali, DL Eizirik
Nature Communications 2020
Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research
M Hu, I Cherkaoui, S Misra, GA Rutter
Frontiers in Endocrinology 2020
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
MI Alvelos, M Brüggemann, FX Sutandy, J Juan-Mateu, ML Colli, A Busch, M Lopes, Â Castela, A Aartsma-Rus, J König, K Zarnack, DL Eizirik
Life science alliance 2020
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function
Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL
Wellcome Open Research 2020
iPreP: A three-dimensional nanofibrillar cellulose hydrogel platform for long-term ex vivo preservation of human islets
Yi-Ju Chen, Taiji Yamazoe, Karla Leavens, Fabian L. Cardenas-Diaz, Andrei Georgescu, Dongeun Huh, Paul Gadue, Ben Stanger
JCI Insight 2019
The supply chain of human pancreatic beta cell lines
Raphaël Scharfmann, Willem Staels, Olivier Albagli-Curiel
Journal of Clinical Investigation 2019
m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes
DF Jesus, Z Zhang, S Kahraman, NK Brown, M Chen, J Hu, MK Gupta, C He, RN Kulkarni
2019
Genome editing of human pancreatic beta cell models: problems, possibilities and outlook
D Balboa, RB Prasad, L Groop, T Otonkoski
Diabetologia 2019
A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration
Y Wang, S Chen, Z Yan, M Pei
Cell & Bioscience 2019
MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
K Tyka, A Jörns, JV Turatsinze, DL Eizirik, S Lenzen, E Gurgul-Convey
Cell Death and Disease 2019
Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function
N Lawlor, EJ Márquez, P Orchard, N Narisu, MS Shamim, A Thibodeau, A Varshney, R Kursawe, MR Erdos, M Kanke, H Gu, E Pak, A Dutra, S Russell, X Li, E Piecuch, O Luo, PS Chines, C Fuchbserger, P Sethupathy, AP Aiden, Y Ruan, EL Aiden, FS Collins, D Ucar, SC Parker, ML Stitzel
Cell Reports 2019
A Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells
L Yi, CF Tsai, E Dirice, AC Swensen, J Chen, T Shi, MA Gritsenko, RK Chu, PD Piehowski, RD Smith, KD Rodland, MA Atkinson, CE Mathews, RN Kulkarni, T Liu, WJ Qian
Analytical Chemistry 2019
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
A Castellanos-Rubio, I Santin, A Olazagoitia-Garmendia, I Romero-Garmendia, A Jauregi-Miguel, M Legarda, JR Bilbao
Scientific Reports 2019
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
S Vig, M Buitinga, D Rondas, I Crèvecoeur, M van Zandvoort, E Waelkens, DL Eizirik, C Gysemans, P Baatsen, C Mathieu, L Overbergh
Cell Death and Disease 2019
Pancreatic β-cells detoxify H 2 O 2 through the peroxiredoxin/thioredoxin antioxidant system
JS Stancill, KA Broniowska, BJ Oleson, A Naatz, JA Corbett
The Journal of biological chemistry 2019
ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor
PL Toledo, JM Torkko, A Müller, C Wegbrod, A Sönmez, M Solimena, MR Ermácora
The Journal of biological chemistry 2019
Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
ML Colli, FM Paula, L Marselli, P Marchetti, M Roivainen, DL Eizirik, AO de beeck
Journal of Innate Immunity 2019
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension
M Baron, J Maillet, M Huyvaert, A Dechaume, R Boutry, H Loiselle, E Durand, B Toussaint, E Vaillant, J Philippe, J Thomas, A Ghulam, S Franc, G Charpentier, JM Borys, C Lévy-Marchal, M Tauber, R Scharfmann, J Weill, C Aubert, J Kerr-Conte, F Pattou, R Roussel, B Balkau, M Marre, M Boissel, M Derhourhi, S Gaget, M Canouil, P Froguel, A Bonnefond
Nature Medicine 2019
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
C Merriman, D Fu
The Journal of biological chemistry 2019
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
OP Dwivedi, M Lehtovirta, B Hastoy, V Chandra, NA Krentz, S Kleiner, D Jain, AM Richard, F Abaitua, NL Beer, A Grotz, RB Prasad, O Hansson, E Ahlqvist, U Krus, I Artner, A Suoranta, D Gomez, A Baras, B Champon, AJ Payne, D Moralli, SK Thomsen, P Kramer, I Spiliotis, R Ramracheya, P Chabosseau, A Theodoulou, R Cheung, M van de Bunt, J Flannick, M Trombetta, E Bonora, CB Wolheim, L Sarelin, RC Bonadonna, P Rorsman, B Davies, J Brosnan, MI McCarthy, T Otonkoski, JO Lagerstedt, GA Rutter, J Gromada, AL Gloyn, T Tuomi, L Groop
Nature Genetics 2019
Production, Characterization, and Function of Pseudoislets from Perinatal Canine Pancreas
P Czernichow, K Reynaud, J Kerr-Conte, E Furthner, P Ravassard
Cell Transplantation 2019
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
M Oshima, S Pechberty, L Bellini, SO Göpel, M Campana, C Rouch, J Dairou, C Cosentino, F Fantuzzi, S Toivonen, P Marchetti, C Magnan, M Cnop, HL Stunff, R Scharfmann
Diabetologia 2019
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
M Ramos-Rodríguez, H Raurell-Vila, ML Colli, MI Alvelos, M Subirana-Granés, J Juan-Mateu, R Norris, JV Turatsinze, ES Nakayasu, BJ Webb-Robertson, JR Inshaw, P Marchetti, L Piemonti, M Esteller, JA Todd, TO Metz, DL Eizirik, L Pasquali
Nature Genetics 2019
A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice
S Demine, RG Ribeiro, J Thevenet, L Marselli, P Marchetti, F Pattou, J Kerr-Conte, N Devoogdt, DL Eizirik
Diabetologia 2019
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function
AK Grotz, F Abaitua, E Navarro-Guerrero, B Hastoy, D Ebner, AL Gloyn
Wellcome Open Research 2019
The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells
FA Grieco, AA Schiavo, F Brozzi, J Juan-Mateu, M Bugliani, P Marchetti, DL Eizirik
Journal of Molecular Endocrinology 2019
Viral like infection induces Human β cell dedifferentiation
Masaya OSHIMA, Klaus-Peter Knoch, Marc Diedisheim, Antje PETZOLD, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo Huang, Stefan Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphaël Scharfmann
JCI Insight 2018
Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
S Culina, AI Lalanne, G Afonso, K Cerosaletti, S Pinto, G Sebastiani, K Kuranda, L Nigi, A Eugster, T Østerbye, A Maugein, JE McLaren, K Ladell, E Larger, JP Beressi, A Lissina, V Appay, HW Davidson, S Buus, DA Price, M Kuhn, E Bonifacio, M Battaglia, S Caillat-Zucman, F Dotta, R Scharfmann, B Kyewski, R Mallone
Science Immunology 2018
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus
D Iacovazzo, SE Flanagan, E Walker, R Quezado, FA de Barros, R Caswell, MB Johnson, M Wakeling, M Brändle, M Guo, MN Dang, P Gabrovska, B Niederle, E Christ, S Jenni, B Sipos, M Nieser, A Frilling, K Dhatariya, P Chanson, WW de Herder, B Konukiewitz, G Klöppel, R Stein, M Korbonits, S Ellard
Proceedings of the National Academy of Sciences 2018
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
S Tunaru, R Bonnavion, I Brandenburger, J Preussner, D Thomas, K Scholich, S Offermanns
Nature Communications 2018
(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives
L Baeyens, M Lemper, W Staels, SD Groef, ND Leu, Y Heremans, MS German, H Heimberg
Physiological reviews 2018
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
B Hastoy, M Godazgar, A Clark, V Nylander, I Spiliotis, M van de Bunt, MV Chibalina, A Barrett, C Burrows, AI Tarasov, R Scharfmann, AL Gloyn, P Rorsman
Scientific Reports 2018
Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
E Oh, M Ahn, S Afelik, TC Becker, BO Roep, DC Thurmond
Diabetes 2018
Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients
S Skrtic, B Tyrberg, M Broberg, H Ericsson, V Schnecke, M Kjaer, M Hompesch, EM Andersson, E Ryberg, A Aivazidis, CW Huldt, L Löfgren, L Morrow, J Parkinson, T Rydén-Bergsten, E Watkins, MS Winzell, E Barengolts
PloS one 2018
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes
C Cosentino, S Toivonen, ED Villamil, M Atta, JL Ravanat, S Demine, AA Schiavo, N Pachera, JP Deglasse, JC Jonas, D Balboa, T Otonkoski, ER Pearson, P Marchetti, DL Eizirik, M Cnop, M Igoillo-Esteve
Nucleic Acids Research 2018
Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca 2+ Sensitivity of Insulin Secretion Vesicles
C Huang, EM Walker, PK Dadi, R Hu, Y Xu, W Zhang, T Sanavia, J Mun, J Liu, GG Nair, HY Tan, S Wang, MA Magnuson, CJ Stoeckert, M Hebrok, M Gannon, W Han, R Stein, DA Jacobson, G Gu
Developmental Cell 2018
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
SK Thomsen, A Raimondo, B Hastoy, S Sengupta, XQ Dai, A Bautista, J Censin, AJ Payne, MM Umapathysivam, AF Spigelman, A Barrett, CJ Groves, NL Beer, JE Fox, MI McCarthy, A Clark, A Mahajan, P Rorsman, PE MacDonald, AL Gloyn
Nature Genetics 2018
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans
C Izzi-Engbeaya, AN Comninos, SA Clarke, A Jomard, L Yang, S Jones, A Abbara, S Narayanaswamy, PC Eng, D Papadopoulou, JK Prague, P Bech, IF Godsland, P Bassett, C Sands, S Camuzeaux, M Gomez-Romero, JT Pearce, MR Lewis, E Holmes, JK Nicholson, T Tan, R Ratnasabapathy, M Hu, G Carrat, L Piemonti, M Bugliani, P Marchetti, PR Johnson, SJ Hughes, AM Shapiro, GA Rutter, WS Dhillo
Diabetes, obesity & metabolism 2018
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction
SF Hansson, AX Zhou, P Vachet, JW Eriksson, MJ Pereira, S Skrtic, HJ Wallin, A Ericsson-Dahlstrand, D Karlsson, A Ahnmark, MS Winzell, MC Magnone, P Davidsson, P Fiorina
PloS one 2018
Porcine Neonatal Pancreatic Cell Clusters Maintain Their Multipotency in Culture and After Transplantation
WC Li, CY Chen, CW Kao, PC Huang, YT Hsieh, TY Kuo, TY Chen, HY Chia, JH Juang
Scientific Reports 2018
BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells
ME Oskarsson, E Hermansson, Y Wang, N Welsh, J Presto, J Johansson, GT Westermark
Proceedings of the National Academy of Sciences 2018
TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes
C Liu, W QiNan, L XiaoTian, Y MengLiu, G XiaGuang, L WeiLing, L ZiWen, Z Ling, Y GangYi, C Bing
Journal of Diabetes Research 2018
Role of Protein Phosphatase 1 and Inhibitor of Protein Phosphatase 1 in Nitric Oxide–Dependent Inhibition of the DNA Damage Response in Pancreatic β-Cells
BJ Oleson, A Naatz, SC Proudfoot, CT Yeo, JA Corbett
Diabetes 2018
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa
S Demine, A Balhuizen, V Debaille, L Joosten, M Fereau, S Chilla, I Millard, R Scharfmann, D Egrise, S Goldman, P Marchetti, M Gotthardt, S Laurent, C Burtea, D Eizirik
Molecules (Basel, Switzerland) 2018
MANF protects human pancreatic beta cells against stress-induced cell death
E Hakonen, V Chandra, CL Fogarty, NY Yu, J Ustinov, S Katayama, E Galli, T Danilova, P Lindholm, A Vartiainen, E Einarsdottir, K Krjutškov, J Kere, M Saarma, M Lindahl, T Otonkoski
Diabetologia 2018
Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism
X Jian, G Felsenfeld
Proceedings of the National Academy of Sciences 2018
Modeling human pancreatic beta cell dedifferentiation
M Diedisheim, M Oshima, O Albagli, CW Huldt, I Ahlstedt, M Clausen, S Menon, A Aivazidis, AC Andreasson, WG Haynes, P Marchetti, L Marselli, M Armanet, F Chimienti, R Scharfmann
Molecular Metabolism 2018
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
M Thurner, M van de Bunt, JM Torres, A Mahajan, V Nylander, AJ Bennett, KJ Gaulton, A Barrett, C Burrows, CG Bell, R Lowe, S Beck, VK Rakyan, AL Gloyn, MI McCarthy
eLife 2018
Feeder-cell-independent culture of the pig embryonic stem cell-derived exocrine pancreatic cell line, PICM-31
NC Talbot, AE Shannon, CE Phillips, WM Garrett
In vitro cellular & developmental biology. Animal 2018
Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells
J Taneera, RB Prasad, S Dhaiban, AK Mohammed, L Haataja, P Arvan, M Hamad, L Groop, CB Wollheim
Molecular and Cellular Endocrinology 2018
Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
E Ifie, MA Russell, S Dhayal, P Leete, G Sebastiani, L Nigi, F Dotta, V Marjomäki, DL Eizirik, NG Morgan, SJ Richardson
Diabetologia 2018
Targeting GLP-1 receptor trafficking to improve agonist efficacy
B Jones, T Buenaventura, N Kanda, P Chabosseau, BM Owen, R Scott, R Goldin, N Angkathunyakul, IR Corrêa, D Bosco, PR Johnson, L Piemonti, P Marchetti, AM Shapiro, BJ Cochran, AC Hanyaloglu, A Inoue, T Tan, GA Rutter, A Tomas, SR Bloom
Nature Communications 2018
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates
VG Tsonkova, FW Sand, XA Wolf, LG Grunnet, AK Ringgaard, C Ingvorsen, L Winkel, M Kalisz, K Dalgaard, C Bruun, JJ Fels, C Helgstrand, S Hastrup, FK Öberg, E Vernet, MP Sandrini, AC Shaw, C Jessen, M Grønborg, J Hald, H Willenbrock, D Madsen, R Wernersson, L Hansson, JN Jensen, A Plesner, T Alanentalo, MB Petersen, A Grapin-Botton, C Honoré, J Ahnfelt-Rønne, J Hecksher-Sørensen, P Ravassard, OD Madsen, C Rescan, T Frogne
Molecular Metabolism 2018
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
ML Colli, JL Hill, L Marroquí, J Chaffey, RS Santos, P Leete, AC de Brachène, FM Paula, AO de Beeck, A Castela, L Marselli, L Krogvold, K Dahl-Jorgensen, P Marchetti, NG Morgan, SJ Richardson, DL Eizirik
EBioMedicine 2018
Differentiation of Sendai virus-reprogrammed iPSC into β cells, compared with human pancreatic islets and immortalized β cell line
S Pellegrini, F Manenti, R Chimienti, R Nano, L Ottoboni, F Ruffini, G Martino, P Ravassard, L Piemonti, V Sordi
Cell Transplantation 2018
The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
X Wang, A Elksnis, P Wikström, E Walum, N Welsh, PO Carlsson, HH Schmidt
PloS one 2018
Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion
M Casimir, G Chaffard, P Maechler
Pflügers Archiv - European Journal of Physiology 2018
The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
KA Leslie, MA Russell, K Taniguchi, SJ Richardson, NG Morgan
Diabetologia 2018
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8
C Merriman, H Li, H Li, D Fu
The Journal of biological chemistry 2018
A neural network based model effectively predicts enhancers from clinical ATAC-seq samples
A Thibodeau, A Uyar, S Khetan, ML Stitzel, D Ucar
Scientific Reports 2018
Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
B Font-Cunill, L Arnes, J Ferrer, L Sussel, A Beucher
Frontiers in Genetics 2018
Bioluminescent reporter assay for monitoring ER stress in human beta cells
MJ Kracht, EJ de Koning, RC Hoeben, BO Roep, A Zaldumbide
Scientific Reports 2018
Modelling the endocrine pancreas in health and disease
M Bakhti, A Böttcher, H Lickert
Nature Reviews Endocrinology 2018
The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass
M Jahan, P Johnström, RK Selvaraju, M Svedberg, MS Winzell, J Bernström, L Kingston, M Schou, Z Jia, S Skrtic, L Johansson, O Korsgren, L Farde, C Halldin, O Eriksson
EJNMMI Research 2018
DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway
RS Santos, L Marroqui, T Velayos, A Olazagoitia-Garmendia, A Jauregi-Miguel, A Castellanos-Rubio, DL Eizirik, L Castaño, I Santin
Diabetologia 2018
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
T Zhou, TW Kim, CN Chong, L Tan, S Amin, ZS Badieyan, S Mukherjee, Z Ghazizadeh, H Zeng, M Guo, M Crespo, T Zhang, R Kenyon, CL Robinson, E Apostolou, H Wang, JZ Xiang, T Evans, L Studer, S Chen
Nature Communications 2018
BiFET: sequencing Bi as-free transcription factor F ootprint E nrichment T est
A Youn, EJ Marquez, N Lawlor, ML Stitzel, D Ucar
Nucleic Acids Research 2018
[Research progress on the donor cell sources of pancreatic islet transplantation for treatment of diabetes mellitus]
Haitao Zhu, Xiaoge Zhang, Yayi He, Liang Yu, Yi Lü, Kaili Pan, Bo Wang, Guoqiang Chen
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 2018
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
AS Axelsson, T Mahdi, HA Nenonen, T Singh, S Hänzelmann, A Wendt, A Bagge, TM Reinbothe, J Millstein, X Yang, B Zhang, EG Gusmao, L Shu, M Szabat, Y Tang, J Wang, S Salö, L Eliasson, I Artner, M Fex, JD Johnson, CB Wollheim, JM Derry, B Mecham, P Spégel, H Mulder, IG Costa, E Zhang, AH Rosengren
Nature Communications 2017
Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion
FK Ndiaye, A Ortalli, M Canouil, M Huyvaert, C Salazar-Cardozo, C Lecoeur, M Verbanck, V Pawlowski, R Boutry, E Durand, I Rabearivelo, O Sand, L Marselli, J Kerr-Conte, V Chandra, R Scharfmann, O Poulain-Godefroy, P Marchetti, F Pattou, A Abderrahmani, P Froguel, A Bonnefond
Molecular Metabolism 2017
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
E Dror, E Dalmas, DT Meier, S Wueest, J Thévenet, C Thienel, K Timper, TM Nordmann, S Traub, F Schulze, F Item, D Vallois, F Pattou, J Kerr-Conte, V Lavallard, T Berney, B Thorens, D Konrad, M Böni-Schnetzler, MY Donath
Nature Immunology 2017
Nutrient regulation of β-cell function: what do islet cell/animal studies tell us?
R Carlessi, KN Keane, C Mamotte, P Newsholme
European Journal of Clinical Nutrition 2017
Optogenetic regulation of insulin secretion in pancreatic β-cells
F Zhang, ES Tzanakakis
Scientific Reports 2017
Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts
N Lawlor, A Youn, R Kursawe, D Ucar, ML Stitzel
Scientific Reports 2017
Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress
A Lombardi, Y Tomer
Journal of Autoimmunity 2017
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
C Cruciani-Guglielmacci, L Bellini, J Denom, M Oshima, N Fernandez, P Normandie-Levi, XP Berney, N Kassis, C Rouch, J Dairou, T Gorman, DM Smith, A Marley, R Liechti, D Kuznetsov, L Wigger, F Burdet, AL Lefèvre, I Wehrle, I Uphues, T Hildebrandt, W Rust, C Bernard, A Ktorza, GA Rutter, R Scharfmann, I Xenarios, HL Stunff, B Thorens, C Magnan, M Ibberson
Molecular Metabolism 2017
Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
L Marroqui, RS Santos, AO de beeck, AC de Brachène, L Marselli, P Marchetti, DL Eizirik
Diabetologia 2017
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
I Akerman, Z Tu, A Beucher, DM Rolando, C Sauty-Colace, M Benazra, N Nakic, J Yang, H Wang, L Pasquali, I Moran, J Garcia-Hurtado, N Castro, R Gonzalez-Franco, AF Stewart, C Bonner, L Piemonti, T Berney, L Groop, J Kerr-Conte, F Pattou, C Argmann, E Schadt, P Ravassard, J Ferrer
Cell Metabolism 2017
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice
GR Carrat, M Hu, MS Nguyen-Tu, P Chabosseau, KJ Gaulton, M de Bunt, A Siddiq, M Falchi, M Thurner, M Canouil, F Pattou, I Leclerc, TJ Pullen, MC Cane, P Prabhala, W Greenwald, A Schulte, P Marchetti, M Ibberson, PE MacDonald, JE Fox, AL Gloyn, P Froguel, M Solimena, MI McCarthy, GA Rutter
The American Journal of Human Genetics 2017
EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium
C Krizhanovskii, H Kristinsson, A Elksnis, X Wang, H Gavali, P Bergsten, R Scharfmann, N Welsh
Islets 2017
β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”
A Vieira, N Druelle, F Avolio, T Napolitano, S Navarro-Sanz, S Silvano, P Collombat
Frontiers in Genetics 2017
Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
H Kristinsson, E Sargsyan, H Manell, DM Smith, SO Göpel, P Bergsten
Scientific Reports 2017
Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
J Juan-Mateu, TH Rech, O Villate, E Lizarraga-Mollinedo, A Wendt, JV Turatsinze, LA Brondani, TR Nardelli, TC Nogueira, JL Esguerra, MI Alvelos, P Marchetti, L Eliasson, DL Eizirik
The Journal of biological chemistry 2017
Confluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines
JK Ofori, HA Malm, IG Mollet, L Eliasson, JL Esguerra
PeerJ 2017
Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells
C Krizhanovskii, RG Fred, ME Oskarsson, GT Westermark, N Welsh
Upsala Journal of Medical Sciences 2017
Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes
JO Nyalwidhe, GR Gallagher, LM Glenn, MA Morris, P Vangala, A Jurczyk, R Bortell, DM Harlan, JP Wang, JL Nadler
Journal of the Endocrine Society 2017
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
DA Cunha, M Cito, FA Grieco, C Cosentino, T Danilova, L Ladrière, M Lindahl, A Domanskyi, M Bugliani, P Marchetti, DL Eizirik, M Cnop
The Journal of biological chemistry 2017
Regenerative medicine and cell-based approaches to restore pancreatic function
C Ellis, A Ramzy, TJ Kieffer
Nature Reviews Gastroenterology & Hepatology 2017
Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions
A Oishi, A Karamitri, R Gerbier, O Lahuna, R Ahmad, R Jockers
Scientific Reports 2017
Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
RS Santos, L Marroqui, FA Grieco, L Marselli, M Suleiman, SR Henz, P Marchetti, R Wernersson, DL Eizirik
Endocrinology 2017
miR-204 is associated with an endocrine phenotype in human pancreatic islets but does not regulate the insulin mRNA through MAFA
I Marzinotto, S Pellegrini, C Brigatti, R Nano, R Melzi, A Mercalli, D Liberati, V Sordi, M Ferrari, M Falconi, C Doglioni, P Ravassard, L Piemonti, V Lampasona
Scientific Reports 2017
A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
A Balhuizen, S Massa, I Mathijs, JV Turatsinze, JD Vos, S Demine, C Xavier, O Villate, I Millard, D Egrise, C Capito, R Scharfmann, PI Veld, P Marchetti, S Muyldermans, S Goldman, T Lahoutte, L Bouwens, DL Eizirik, N Devoogdt
Scientific Reports 2017
MiR‐335 overexpression impairs insulin secretion through defective priming of insulin vesicles
VA Salunkhe, JK Ofori, NR Gandasi, SA Salö, S Hansson, ME Andersson, A Wendt, S Barg, JL Esguerra, L Eliasson
Physiological Reports 2017
Dynamics of Insulin Secretion from EndoC- β H1 β -Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues
H Teraoku, S Lenzen
Journal of Diabetes Research 2017
SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival
J Juan-Mateu, MI Alvelos, JV Turatsinze, O Villate, E Lizarraga-Mollinedo, FA Grieco, L Marroquí, M Bugliani, P Marchetti, DL Eizirik
Diabetes 2017
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
M Solimena, AM Schulte, L Marselli, F Ehehalt, D Richter, M Kleeberg, H Mziaut, KP Knoch, J Parnis, M Bugliani, A Siddiq, A Jörns, F Burdet, R Liechti, M Suleiman, D Margerie, F Syed, M Distler, R Grützmann, E Petretto, A Moreno-Moral, C Wegbrod, A Sönmez, K Pfriem, A Friedrich, J Meinel, CB Wollheim, GB Baretton, R Scharfmann, E Nogoceke, E Bonifacio, D Sturm, B Meyer-Puttlitz, U Boggi, HD Saeger, F Filipponi, M Lesche, P Meda, A Dahl, L Wigger, I Xenarios, M Falchi, B Thorens, J Weitz, K Bokvist, S Lenzen, GA Rutter, P Froguel, M von Bülow, M Ibberson, P Marchetti
Diabetologia 2017
Xenotropic retrovirus Bxv1 in human pancreatic β cell lines
Jeannette Kirkegaard, Philippe Ravassard, Signe Ingvarsen, Marc Diedisheim, Emilie Bricout-Neveu, Mads Grønborg, Thomas Frogne, Raphaël Scharfmann, Ole Madsen, Claude Rescan, Olivier Albagli-Curiel
Journal of Clinical Investigation 2016
Stress-Impaired Transcription Factor Expression and Insulin Secretion in Human Islets
Chunhua Dai, Nora Kayton, Alena Shostak, Gregory Poffenberger, Holly Ann Cyphert, Radhika Aramandla, Courtney Thompson, Ioannis Papagiannis, Christopher Emfinger, Masakazu Shiota, John Stafford, Dale Greiner, Pedro Luis Herrera, Leonard Shultz, Roland Stein, Alvin Powers
Journal of Clinical Investigation 2016
Research Resource: Genetic Labeling of Human Islet Alpha Cells
PT Pauerstein, KM Park, HS Peiris, J Wang, SK Kim
Molecular Endocrinology 2016
Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines
E Gurgul-Convey, I Mehmeti, T Plötz, A Jörns, S Lenzen
Diabetologia 2016
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice
ZB Mehta, N Fine, TJ Pullen, MC Cane, M Hu, P Chabosseau, G Meur, A Velayos-Baeza, AP Monaco, L Marselli, P Marchetti, GA Rutter
American journal of physiology. Endocrinology and metabolism 2016
Aggregation of Engineered Human β-Cells into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu
MJ Lecomte, S Pechberty, C Machado, SD Barroca, P Ravassard, R Scharfmann, P Czernichow, B Duvillié
Cell medicine 2016
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology
NL Beer, AL Gloyn
F1000Research 2016
Identification of proliferative and mature β-cells in the islets of Langerhans
E Bader, A Migliorini, M Gegg, N Moruzzi, J Gerdes, SS Roscioni, M Bakhti, E Brandl, M Irmler, J Beckers, M Aichler, A Feuchtinger, C Leitzinger, H Zischka, R Wang-Sattler, M Jastroch, M Tschöp, F Machicao, H Staiger, HU Häring, H Chmelova, JA Chouinard, N Oskolkov, O Korsgren, S Speier, H Lickert
Nature 2016
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
F Brozzi, DL Eizirik
Upsala Journal of Medical Sciences 2016
Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells
F Brozzi, S Gerlo, FA Grieco, M Juusola, A Balhuizen, S Lievens, C Gysemans, M Bugliani, C Mathieu, P Marchetti, J Tavernier, DL Eizirik
The Journal of biological chemistry 2016
MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes
E Ganic, T Singh, C Luan, J Fadista, JK Johansson, HA Cyphert, H Bennet, P Storm, G Prost, H Ahlenius, E Renström, R Stein, L Groop, M Fex, I Artner
Cell Reports 2016
β-Cell glutamate signaling: Its role in incretin-induced insulin secretion
N Yokoi, G Gheni, H Takahashi, S Seino
Journal of Diabetes Investigation 2016
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
HE Arda, L Li, J Tsai, EA Torre, Y Rosli, H Peiris, RC Spitale, C Dai, X Gu, K Qu, P Wang, J Wang, M Grompe, R Scharfmann, MS Snyder, R Bottino, AC Powers, HY Chang, SK Kim
Cell Metabolism 2016
The Importance of Context: Uncovering Species- and Tissue-Specific Effects of Genetic Risk Variants for Type 2 Diabetes
SK Thomsen, MI McCarthy, AL Gloyn
Frontiers in Endocrinology 2016
PTB and TIAR binding to insulin mRNA 3′- and 5′UTRs; implications for insulin biosynthesis and messenger stability
RG Fred, S Mehrabi, CM Adams, N Welsh
Heliyon 2016
A Protocol to Enhance INS1E and MIN6 Functionality—The Use of Theophylline
MG Nibbelink, G Marchioli, L Moroni, M Karperien, AV Apeldoorn
International journal of molecular sciences 2016
Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response
BJ Oleson, KA Broniowska, A Naatz, N Hogg, VL Tarakanova, JA Corbett
Molecular and cellular biology 2016
Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells
V Chandra, A Karamitri, P Richards, F Cormier, C Ramond, R Jockers, M Armanet, O Albagli-Curiel, R Scharfmann
Scientific Reports 2016
Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes
JA Olsen, LA Kenna, MG Spelios, MJ Hessner, EM Akirav, R Kulkarni
PloS one 2016
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants
SK Thomsen, A Ceroni, M de Bunt, C Burrows, A Barrett, R Scharfmann, D Ebner, MI McCarthy, AL Gloyn
Diabetes 2016
Immunogenicity of human embryonic stem cell-derived beta cells
CR van der Torren, A Zaldumbide, G Duinkerken, SH Brand-Schaaf, M Peakman, G Stangé, L Martinson, E Kroon, EP Brandon, D Pipeleers, BO Roep
Diabetologia 2016
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
FA Grieco, G Sebastiani, J Juan-Mateu, O Villate, L Marroqui, L Ladrière, K Tugay, R Regazzi, M Bugliani, P Marchetti, F Dotta, DL Eizirik
Diabetes 2016
Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice
AD Green, S Vasu, NH McClenaghan, PR Flatt
World journal of diabetes 2016
DNA methylation directs functional maturation of pancreatic beta cells
Sangeeta Dhawan, Shuen-ing Tschen, Chun Zeng, Tingxia Guo, Matthias Hebrok, Aleksey Matveyenko, Anil Bhushan
Journal of Clinical Investigation 2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mägi, ME Reschen, A Mahajan, A Locke, NW Rayner, N Robertson, RA Scott, I Prokopenko, LJ Scott, T Green, T Sparso, D Thuillier, L Yengo, H Grallert, S Wahl, M Frånberg, RJ Strawbridge, H Kestler, H Chheda, L Eisele, S Gustafsson, V Steinthorsdottir, G Thorleifsson, L Qi, LC Karssen, EM van Leeuwen, SM Willems, M Li, H Chen, C Fuchsberger, P Kwan, C Ma, M Linderman, Y Lu, SK Thomsen, JK Rundle, NL Beer, M de Bunt, A Chalisey, HM Kang, BF Voight, GR Abecasis, P Almgren, D Baldassarre, B Balkau, R Benediktsson, M Blüher, H Boeing, LL Bonnycastle, EP Bottinger, NP Burtt, J Carey, G Charpentier, PS Chines, MC Cornelis, DJ Couper, AT Crenshaw, RM van Dam, AS Doney, M Dorkhan, S Edkins, JG Eriksson, T Esko, E Eury, J Fadista, J Flannick, P Fontanillas, C Fox, PW Franks, K Gertow, C Gieger, B Gigante, O Gottesman, GB Grant, N Grarup, CJ Groves, M Hassinen, CT Have, C Herder, OL Holmen, AB Hreidarsson, SE Humphries, DJ Hunter, AU Jackson, A Jonsson, ME Jørgensen, T Jørgensen, WH Kao, ND Kerrison, L Kinnunen, N Klopp, A Kong, P Kovacs, P Kraft, J Kravic, C Langford, K Leander, L Liang, P Lichtner, CM Lindgren, E Lindholm, A Linneberg, CT Liu, S Lobbens, J Luan, V Lyssenko, S Männistö, O McLeod, J Meyer, E Mihailov, G Mirza, TW Mühleisen, M Müller-Nurasyid, C Navarro, MM Nöthen, NN Oskolkov, KR Owen, D Palli, S Pechlivanis, L Peltonen, JR Perry, CG Platou, M Roden, D Ruderfer, D Rybin, YT van der Schouw, B Sennblad, G Sigurðsson, A Stančáková, G Steinbach, P Storm, K Strauch, HM Stringham, Q Sun, B Thorand, E Tikkanen, A Tonjes, J Trakalo, E Tremoli, T Tuomi, R Wennauer, S Wiltshire, AR Wood, E Zeggini, I Dunham, E Birney, L Pasquali, J Ferrer, RJ Loos, J Dupuis, JC Florez, E Boerwinkle, JS Pankow, C Duijn, E Sijbrands, JB Meigs, FB Hu, U Thorsteinsdottir, K Stefansson, TA Lakka, R Rauramaa, M Stumvoll, NL Pedersen, L Lind, SM Keinanen-Kiukaanniemi, E Korpi-Hyövälti, TE Saaristo, J Saltevo, J Kuusisto, M Laakso, A Metspalu, R Erbel, KH Jöcke, S Moebus, S Ripatti, V Salomaa, E Ingelsson, BO Boehm, RN Bergman, FS Collins, KL Mohlke, H Koistinen, J Tuomilehto, K Hveem, I Njølstad, P Deloukas, PJ Donnelly, TM Frayling, AT Hattersley, U Faire, A Hamsten, T Illig, A Peters, S Cauchi, R Sladek, P Froguel, T Hansen, O Pedersen, AD Morris, CN Palmer, S Kathiresan, O Melander, PM Nilsson, LC Groop, I Barroso, C Langenberg, NJ Wareham, CA O'Callaghan, AL Gloyn, D Altshuler, M Boehnke, TM Teslovich, MI McCarthy, AP Morris
Nature Genetics 2015
Diabetes mellitus—advances and challenges in human β-cell proliferation
P Wang, NM Fiaschi-Taesch, RC Vasavada, DK Scott, A García-Ocaña, AF Stewart
Nature Reviews Endocrinology 2015
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
C Tang, K Ahmed, A Gille, S Lu, HJ Gröne, S Tunaru, S Offermanns
Nature Medicine 2015
Dynamic Recruitment of Functionally Distinct Swi/Snf Chromatin Remodeling Complexes Modulates Pdx1 Activity in Islet β Cells
B McKenna, M Guo, A Reynolds, M Hara, R Stein
Cell Reports 2015
Human islet distribution programme for basic research: activity over the last 5 years
R Nano, D Bosco, JA Kerr-Conte, M Karlsson, S Charvier, R Melzi, R Ezzouaoui, A Mercalli, A Hwa, F Pattou, O Korsgren, T Berney, L Piemonti
Diabetologia 2015
Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets
J Hilderink, S Spijker, F Carlotti, L Lange, M Engelse, C Blitterswijk, E Koning, M Karperien, A Apeldoorn
Journal of Cellular and Molecular Medicine 2015
Co-Culture of α TC-6 Cells and β TC-1 Cells: Morphology and Function
SM Kim, EJ Lee, HS Jung, N Han, YJ Kim, TK Kim, TN Kim, MJ Kwon, SH Lee, JH Park, BD Rhee, MK Kim
Endocrinology and Metabolism 2015
Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line
LE Andersson, B Valtat, A Bagge, VV Sharoyko, DG Nicholls, P Ravassard, R Scharfmann, P Spégel, H Mulder, B Wagner
PloS one 2015
Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
F Brozzi, TR Nardelli, M Lopes, I Millard, J Barthson, M Igoillo-Esteve, FA Grieco, O Villate, JM Oliveira, M Casimir, M Bugliani, F Engin, GS Hotamisligil, P Marchetti, DL Eizirik
Diabetologia 2015
Analysis artefacts of the INS-IGF2 fusion transcript
R Wernersson, T Frogne, C Rescan, L Hansson, C Bruun, M Grønborg, JN Jensen, OD Madsen
BMC Molecular Biology 2015
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines
BJ Oleson, JA McGraw, KA Broniowska, M Annamalai, J Chen, JR Bushkofsky, DB Davis, JA Corbett, CE Mathews
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2015
A human beta cell line with drug inducible excision of immortalizing transgenes
M Benazra, MJ Lecomte, C Colace, A Müller, C Machado, S Pechberty, E Bricout-Neveu, M Grenier-Godard, M Solimena, R Scharfmann, P Czernichow, P Ravassard
Molecular Metabolism 2015
MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
DW Scoville, HA Cyphert, L Liao, J Xu, A Reynolds, S Guo, R Stein
Diabetes 2015
Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy
CR van der Torren, A Zaldumbide, DL Roelen, G Duinkerken, SH Brand-Schaaf, M Peakman, P Czernichow, P Ravassard, R Scharfmann, BO Roep
Diabetologia 2015
Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans
A Pal, TP Potjer, SK Thomsen, HJ Ng, A Barrett, R Scharfmann, TJ James, DT Bishop, F Karpe, IF Godsland, HF Vasen, J Newton-Bishop, H Pijl, MI McCarthy, AL Gloyn
Diabetes 2015
Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
L Paul, EM Walker, Y Drosos, HA Cyphert, G Neale, R Stein, J South, G Grosveld, PL Herrera, B Sosa-Pineda
Diabetes 2015
The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro
K Meyerovich, M Fukaya, LF Terra, F Ortis, DL Eizirik, AK Cardozo
Diabetologia 2015
When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes
S Althari, AL Gloyn
The review of diabetic studies : RDS 2015
A conditionally immortalized human pancreatic beta cell line
Raphaël Scharfmann, Severine Pechberty, Yasmine Hazhouz, Manon von Bülow, Emilie Bricout-Neveu, Maud Grenier-Godard, Fanny Guez, Latif Rachdi, Mathias Lohmann, Paul Czernichow, Philippe Ravassard
Journal of Clinical Investigation 2014
A New Method for Generating Insulin-secreting Cells from Human Pancreatic Epithelial Cells after Islet Isolation Transformed by NeuroD1
M Shimoda, S Chen, H Noguchi, M Takita, K Sugimoto , T Itoh, D Chujo, S Iwahashi, B Naziruddin, MF Levy, S Matsumoto , P Grayburn
Human Gene Therapy Methods 2014
Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes
M Figliuzzi, B Bonandrini, S Silvani, A Remuzzi
World journal of stem cells 2014
Targeting the pancreatic β-cell to treat diabetes
A Vetere, A Choudhary, SM Burns, BK Wagner
Nature Reviews Drug Discovery 2014
Adult tissue sources for new β cells
RJ Nichols, C New, JP Annes
Translational Research 2014
The Missing lnc(RNA) between the pancreatic β-cell and diabetes
V Kameswaran, KH Kaestner
Frontiers in Genetics 2014
In search of a surrogate: engineering human beta cell lines for therapy
BN Newby, N Terada, CE Mathews
Trends in Endocrinology & Metabolism 2014
Revealing transcription factors during human pancreatic β cell development
E Conrad, R Stein, CS Hunter
Trends in Endocrinology & Metabolism 2014
The pancreatic β cell: recent insights from human genetics
SK Thomsen, AL Gloyn
Trends in Endocrinology & Metabolism 2014
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
L Pasquali, KJ Gaulton, SA Rodríguez-Seguí, L Mularoni, I Miguel-Escalada, İ Akerman, JJ Tena, I Morán, C Gómez-Marín, M de Bunt, J Ponsa-Cobas, N Castro, T Nammo, I Cebola, J García-Hurtado, MA Maestro, F Pattou, L Piemonti, T Berney, AL Gloyn, P Ravassard, JL Skarmeta, F Müller, MI McCarthy, J Ferrer
Nature Genetics 2014
Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans
JL Esguerra, L Eliasson
Frontiers in Genetics 2014
A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells
F Brozzi, S Gerlo, FA Grieco, TR Nardelli, S Lievens, C Gysemans, L Marselli, P Marchetti, C Mathieu, J Tavernier, DL Eizirik
The Journal of biological chemistry 2014
In Vitro Differentiation and Expansion of Human Pluripotent Stem Cell-Derived Pancreatic Progenitors
J Chmielowiec, M Borowiak
The review of diabetic studies : RDS 2014
Islet β cell mass in diabetes and how it relates to function, birth, and death
GC Weir, S Bonner-Weir
Annals of the New York Academy of Sciences 2013
Animal models of GWAS-identified type 2 diabetes genes
GS Xavier, EA Bellomo, JA McGinty, PM French, GA Rutter
Journal of Diabetes Research 2013
Bridging the Gap Between Genetic Associations and Molecular Mechanisms for Type 2 Diabetes
HJ Ng, AL Gloyn
Current Diabetes Reports 2013
Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl
D Mokhtari, A Al-Amin, K Turpaev, T Li, O Idevall-Hagren, J Li, A Wuttke, RG Fred, P Ravassard, R Scharfmann, A Tengholm, N Welsh
Diabetologia 2013
miR-25 and miR-92a regulate insulin I biosynthesis in rats
DS Karolina, S Sepramaniam, HZ Tan, A Armugam, K Jeyaseelan
RNA biology 2013
Public-private partnerships as driving forces in the quest for innovative medicines
M Goldman, C Compton, BB Mittleman
Clinical and Translational Medicine 2013
IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets
FA Grieco, F Moore, F Vigneron, I Santin, O Villate, L Marselli, D Rondas, H Korf, L Overbergh, F Dotta, P Marchetti, C Mathieu, DL Eizirik
Diabetologia 2013
Human fetal pancreatic islet-like structures as source material to treat type 1 diabetes
Y Ikeda, YC Kudva
Stem Cell Research & Therapy 2013
The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis
M de Bunt, KJ Gaulton, L Parts, I Moran, PR Johnson, CM Lindgren, J Ferrer, AL Gloyn, MI McCarthy
PloS one 2013
Concise review: in search of unlimited sources of functional human pancreatic beta cells
R Scharfmann, L Rachdi, P Ravassard
Stem Cells Translational Medicine 2012
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
I Morán, İ Akerman, M van de Bunt, R Xie, M Benazra, T Nammo, L Arnes, N Nakić, J García-Hurtado, S Rodríguez-Seguí, L Pasquali, C Sauty-Colace, A Beucher, R Scharfmann, J van Arensbergen, PR Johnson, A Berry, C Lee, T Harkins, V Gmyr, F Pattou, J Kerr-Conte, L Piemonti, T Berney, N Hanley, AL Gloyn, L Sussel, L Langman, KL Brayman, M Sander, MI McCarthy, P Ravassard, J Ferrer
Cell Metabolism 2012
Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines
YL Lightfoot, J Chen, CE Mathews
European Journal of Clinical Investigation 2012
Inherited  -Cell Dysfunction in Lean Individuals With Type 2 Diabetes
AE Mathews, CE Mathews
Diabetes 2012
Public-private partnerships need honest brokering
M Goldman
Nature Medicine 2012
Finally! A human pancreatic beta cell line
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Journal of Clinical Investigation 2011
Pulmonary surfactant: an immunological perspective
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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