Despite intense efforts over the past 30 years, human pancreatic β cell lines have not been available. Here, we describe a robust technology for producing a functional human β cell line using targeted oncogenesis in human fetal tissue. Human fetal pancreatic buds were transduced with a lentiviral vector that expressed SV40LT under the control of the insulin promoter. The transduced buds were then grafted into SCID mice so that they could develop into mature pancreatic tissue. Upon differentiation, the newly formed SV40LT-expressing β cells proliferated and formed insulinomas. The resulting β cells were then transduced with human telomerase reverse transcriptase (hTERT), grafted into other SCID mice, and finally expanded in vitro to generate cell lines. One of these cell lines, EndoC-βH1, expressed many β cell–specific markers without any substantial expression of markers of other pancreatic cell types. The cells secreted insulin when stimulated by glucose or other insulin secretagogues, and cell transplantation reversed chemically induced diabetes in mice. These cells represent a unique tool for large-scale drug discovery and provide a preclinical model for cell replacement therapy in diabetes. This technology could be generalized to generate other human cell lines when the cell type–specific promoter is available.
Philippe Ravassard, Yasmine Hazhouz, Séverine Pechberty, Emilie Bricout-Neveu, Mathieu Armanet, Paul Czernichow, Raphael Scharfmann
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SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2.
Katarzyna Blaszczyk, Anna Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine Beamish, Jolanta Chmielowiec, Omaima Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak |
Experimental & molecular medicine | 2025 |
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
Farooq Syed, Olivia Ballew, Chih-Chun Lee, Jyoti Rana, Preethi Krishnan, Angela Castela, Staci A. Weaver, Namratha Chalasani, Sofia Thomaidou, Stephane Demine, Garrick Chang, Alexandra Brachène, Maria Alvelos, Lorella Marselli, Kara Orr, Jamie Felton, Jing Liu, Piero Marchetti, Arnaud Zaldumbide, Donalyn Scheuner, Decio Eizirik, Carmella Evans-Molina |
EBioMedicine | 2025 |
Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity
Austin MC, Muralidharan C, Roy S, Crowder JJ, Piganelli JD, Linnemann AK |
Frontiers in Immunology | 2025 |
A perfect islet: reviewing recent protocol developments and proposing strategies for stem cell derived functional pancreatic islets
Sali S, Azzam L, Jaro T, Ali AA, Mardini A, Al-Dajani O, Khattak S, Butler AE, Azeez JM, Nandakumar M |
Stem Cell Research & Therapy | 2025 |
The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells
Rivada AR, de Oliveira JG, Martin-Vazquez Garcia ME, de Brachene AC, Yi X, Junior JC, Zimath P, Van Goethem F, Pattou F, Kerr-Conte J, Buemi A, Mourad N, Eizirik D |
Research Square | 2025 |
Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans
Russ-Silsby J, Lee Y, Rajesh V, Amoli M, Mirhosseini NA, Godbole T, Johnson MB, Ibarra DE, Sun H, Krentz NA, Wakeling MN, Flanagan SE, Hattersley AT, Gloyn AL, De Franco E |
medRxiv | 2025 |
Comprehensive sequencing profile and functional analysis of IsomiRs in human pancreatic islets and beta cells.
Auddino S, Aiello E, Grieco GE, Fignani D, Licata G, Bruttini M, Mori A, Berteramo AF, Pedace E, Nigi L, Formichi C, Guay C, Quero G, Tondolo V, Di Giuseppe G, Soldovieri L, Ciccarelli G, Mari A, Giaccari A, Mezza T, Po A, Regazzi R, Dotta F, Sebastiani G |
Diabetologia | 2025 |
Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis.
Costa-Junior JM, Coomans de Brachène A, Musuaya AE, Zimath PL, Martin-Vazquez E, Oliveira JG, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL |
Diabetologia | 2025 |
Mechanistic insights and approaches for beta cell regeneration.
Karampelias C, Liu KC, Tengholm A, Andersson O |
Nature chemical biology | 2025 |
Methylprednisolone Protects Human Pancreatic Beta Cells From Inflammation-induced Damage
Paz-Barba M, Peters IJ, de Graaf N, Carlotti F, de Koning EJ |
Transplantation Direct | 2025 |
Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells
Velasco K, Torsvik J, St-Louis JL, Baghestani S, Silvander JS, Kulkarni RN, Toivola DM, Molven A |
BMC Molecular and Cell Biology | 2025 |
BMP5 signalling in beta cells and the impact on insulin secretion in the context of type 2 diabetes.
Dekker E, de Winter TJJ, Muñoz Garcia A, de Graaf N, Roodzant MJ, de Koning EJP, Carlotti F |
Diabetologia | 2025 |
A splice-site variant in MADD affects hormone expression in pancreatic β-cells and pituitary gonadotropes
Kristiina Pulli, Jonna Saarimäki-Vire, Pekka Ahonen, Hazem Ibrahim, Vikash Chandra, Alice Santambrogio, Yafei Wang, Kirsi Vaaralahti, Anna-Pauliina Iivonen, Johanna Känsäkoski, Johanna Tommiska, Sanna Vuoristo, Cynthia Andoniadou, Timo Otonkoski, Taneli Raivio |
JCI Insight | 2024 |
The succinate receptor SUCNR1 regulates insulin secretion with implications in people with prediabetes
Joan Sabadell-Basallote, Brenno Astiarraga, Miriam Ejarque, Maria Repollés-de-Dalmau, Jordi Blanco, Catalina Nuñez-Roa, M-Mar Rodríguez-Peña, Laia Martínez, Dario Jesus, Laura Marroquí, Ramon Bosch, Eduard Montanya, Francesc Sureda, Andrea Tura, Andrea Mari, Rohit Kulkarni, Joan Vendrell, Sonia Fernández-Veledo |
Journal of Clinical Investigation | 2024 |
ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion
Wei Tan, Lillian Lim, Nesha Afsha, Gloria Chan, Carmen Ching, Gokce Oguz, Suat Neo, Safiah Ali, Adaikalavan Ramasamy, Jayantha Gunaratne, Walter Hunziker, Chin Khoo, Adrian Teo |
PNAS nexus | 2024 |
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.
Coomans de Brachène A, Alvelos MI, Szymczak F, Zimath PL, Castela A, Marmontel de Souza B, Roca Rivada A, Marín-Cañas S, Yi X, Op de Beeck A, Morgan NG, Sonntag S, Jawurek S, Title AC, Yesildag B, Pattou F, Kerr-Conte J, Montanya E, Nacher M, Marselli L, Marchetti P, Richardson SJ, Eizirik DL |
Diabetologia | 2024 |
Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
F De Jesus D, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN |
Nature Cell Biology | 2024 |
(Re-)Viewing Role of Intracellular Glucose Beyond Extracellular Regulation of Glucose-Stimulated Insulin Secretion by Pancreatic Cells.
Firdos, Pramanik T, Verma P, Mittal A |
ACS Omega | 2024 |
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells
Ghiasi SM, Marchetti P, Piemonti L, Nielsen JH, Porse BT, Mandrup-Poulsen T, Rutter GA |
Frontiers in Endocrinology | 2024 |
Studies on Treatment Within the Scope of Medical Biotechnology for Pancreatic Diseases.
Aylar D, Karatug Kacar A |
Molecular Biotechnology | 2024 |
Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
Kasinathan D, Guo Z, Sarver DC, Wong GW, Yun S, Michels AW, Yu L, Sona C, Poy MN, Golson ML, Fu D |
Diabetes | 2024 |
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
Syed F, Ballew O, Lee CC, Rana J, Krishnan P, Castela A, Weaver SA, Chalasani NS, Thomaidou SF, Demine S, Chang G, Coomans de Brachène A, Alvelos MI, Marselli L, Orr K, Felton JL, Liu J, Marchetti P, Zaldumbide A, Scheuner D, Eizirik DL, Evans-Molina C |
2024 | |
Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes
Zhu S, Waeckel-Énée E, Oshima M, Moser A, Bessard MA, Gdoura A, Roger K, Mode N, Lipecka J, Yilmaz A, Bertocci B, Diana J, Saintpierre B, Guerrera IC, Scharfmann R, Francesconi S, Mauvais FX, van Endert P |
iScience | 2024 |
Developmentally dynamic changes in DNA methylation in the human pancreas
MacCalman A, De Franco E, Franklin A, Flaxman CS, Richardson SJ, Murrall K, Burrage J, Walker EM, Morgan NG, Hattersley AT, Dempster EL, Hannon E, Jeffries AR, Owens ND, Mill J |
BMC Genomics | 2024 |
Extracellular electrophysiology on clonal human β-cell spheroids
Puginier E, Leal-Fischer K, Gaitan J, Lallouet M, Scotti PA, Raoux M, Lang J |
Frontiers in Endocrinology | 2024 |
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes
Ng NH, Ghosh S, Bok CM, Ching C, Low BS, Chen JT, Lim E, Miserendino MC, Tan YS, Hoon S, Teo AK |
Nature Communications | 2024 |
High-Throughput Methods for the Discovery of Small Molecule Modulators of Pancreatic Beta-Cell Function and Regeneration
McCarty SM, Clasby MC, Sexton JZ |
ASSAY and Drug Development Technologies | 2024 |
Untangling the genetics of beta cell dysfunction and death in type 1 diabetes
Robertson CC, Elgamal RM, Henry-Kanarek BA, Arvan P, Chen S, Dhawan S, Eizirik DL, Kaddis JS, Vahedi G, Parker SC, Gaulton KJ, Soleimanpour SA |
Molecular Metabolism | 2024 |
Cell type- and transcription-independent spatial proximity between enhancers and promoters
Mian Y, Wang L, Keikhosravi A, Guo K, Misteli T, Arda HE, Finn EH |
Molecular biology of the cell | 2024 |
Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model
Jaffredo M, Krentz NA, Champon B, Duff CE, Nawaz S, Beer N, Honore C, Clark A, Rorsman P, Lang J, Gloyn AL, Raoux M, Hastoy B |
Diabetes | 2024 |
Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation
Dekkers MC, Lambooij JM, Pu X, Fagundes RR, Enciso-Martinez A, Kats K, Giepmans BN, Guigas B, Zaldumbide A |
Frontiers in immunology | 2024 |
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function
Meulebrouck S, Merrheim J, Queniat G, Bourouh C, Derhourhi M, Boissel M, Yi X, Badreddine A, Boutry R, Leloire A, Toussaint B, Amanzougarene S, Vaillant E, Durand E, Loiselle H, Huyvaert M, Dechaume A, Scherrer V, Marchetti P, Balkau B, Charpentier G, Franc S, Marre M, Roussel R, Scharfmann R, Cnop M, Canouil M, Baron M, Froguel P, Bonnefond A |
Nature Communications | 2024 |
IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion.
Westholm E, Karagiannopoulos A, Kattner N, Al-Selwi Y, Merces G, Shaw JAM, Wendt A, Eliasson L |
iScience | 2024 |
m(6)A mRNA methylation by METTL14 regulates early pancreatic cell differentiation.
Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN |
The EMBO journal | 2024 |
Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
Rao C, Cater DT, Roy S, Xu J, Olivera AD, Evans-Molina C, Piganelli JD, Eizirik DL, Mirmira RG, Sims EK |
bioRxiv | 2024 |
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Grenko CM, Taylor HJ, Bonnycastle LL, Xue D, Lee BN, Weiss Z, Yan T, Swift AJ, Mansell EC, Lee A, Robertson CC, Narisu N, Erdos MR, Chen S, Collins FS, Taylor DL |
Diabetologia | 2024 |
Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis.
Ahn M, Dhawan S, McCown EM, Garcia PA, Bhattacharya S, Stein R, Thurmond DC |
Diabetologia | 2024 |
Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains.
Esparza D, Lima C, Abuelreich S, Ghaeli I, Hwang J, Oh E, Lenz A, Gu A, Jiang N, Kandeel F, Thurmond DC, Jovanovic-Talisman T |
Frontiers in endocrinology | 2024 |
Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8(+) T cell activity and biomarker during the evolution of type 1 diabetes.
Rao C, Cater DT, Roy S, Xu J, De Oliveira AG, Evans-Molina C, Piganelli JD, Eizirik DL, Mirmira RG, Sims EK |
Diabetologia | 2024 |
A novel microRNA promotes coxsackievirus B4 infection of pancreatic β cells
Lalani S, Knudsen J, Kenney J, Hober D, DiPersio CM, Gerber A |
Frontiers in Immunology | 2024 |
The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells
Bonfim MF, Aitchedji C, Van Goethem F, Sauvage L, Poinsot T, Calonne E, Deplus R, Fuks F, Eizirik DL, Op de Beeck A |
Frontiers in Microbiology | 2024 |
EndoC-βH3 pseudoislets are suitable for intraportal transplantation in diabetic mice
Zhou M, Linn T, Petry SF |
Islets | 2024 |
Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity
Jeeyeon Cha, Xin Tong, Emily Walker, Tehila Dahan, Veronica Cochrane, Sudipta Ashe, Ronan Russell, Anna Osipovich, Alex Mawla, Min Guo, Jin-hua Liu, Mark Huising, Mark Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein |
JCI Insight | 2023 |
In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities
Halliez C, Ibrahim H, Otonkoski T, Mallone R |
Frontiers in Endocrinology | 2023 |
Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine
Ngamjariyawat A, Cen J, Said R, Incedal C, Idevall-Hagren O, Welsh N |
Frontiers in Endocrinology | 2023 |
Inhibition of RIPK1 kinase does not affect diabetes development: β-Cells survive RIPK1 activation
Takiishi T, Xiao P, Franchimont M, Gilglioni EH, Arroba EN, Gurzov EN, Bertrand MJ, Cardozo AK |
Molecular Metabolism | 2023 |
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL |
Diabetologia | 2023 |
Pancreatic microexons regulate islet function and glucose homeostasis.
Juan-Mateu J, Bajew S, Miret-Cuesta M, Íñiguez LP, Lopez-Pascual A, Bonnal S, Atla G, Bonàs-Guarch S, Ferrer J, Valcárcel J, Irimia M |
Nature metabolism | 2023 |
Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane
Mohammad Al-Amily I, Sjögren M, Duner P, Tariq M, Wollheim CB, Salehi A |
Biomolecules | 2023 |
BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
Perez-Serna AA, Dos Santos RS, Ripoll C, Nadal A, Eizirik DL, Marroqui L |
International journal of molecular sciences | 2023 |
Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death.
Roca-Rivada A, Marín-Cañas S, Colli ML, Vinci C, Sawatani T, Marselli L, Cnop M, Marchetti P, Eizirik DL |
Diabetologia | 2023 |
GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.
Gorgogietas V, Rajaei B, Heeyoung C, Santacreu BJ, Marín-Cañas S, Salpea P, Sawatani T, Musuaya A, Arroyo MN, Moreno-Castro C, Benabdallah K, Demarez C, Toivonen S, Cosentino C, Pachera N, Lytrivi M, Cai Y, Carnel L, Brown C, Urano F, Marchetti P, Gilon P, Eizirik DL, Cnop M, Igoillo-Esteve M |
Diabetologia | 2023 |
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy
Wing Yan SO, Yilie Liao, Wai Nam Liu, Guy A Rutter, Weiping Han |
EMBO Molecular Medicine | 2023 |
Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
Frørup C, Gerwig R, Svane CA, Mendes Lopes de Melo J, Henriksen K, Fløyel T, Pociot F, Kaur S, Størling J |
Frontiers in Endocrinology | 2023 |
Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists
Umapathysivam MM, Araldi E, Hastoy B, Dawed AY, Vatandaslar H, Sengupta S, Kaufmann A, Thomsen S, Hartmann B, Jonsson AE, Kabakci H, Thaman S, Grarup N, Have CT, Færch K, Gjesing AP, Nawaz S, Cheeseman J, Neville MJ, Pedersen O, Walker M, Jennison C, Hattersley AT, Hansen T, Karpe F, Holst JJ, Jones AG, Ristow M, McCarthy MI, Pearson ER, Stoffel M, Gloyn AL |
2023 | |
The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo
Davidson RK, Kanojia S, Wu W, Kono T, Xu J, Osmulski M, Bone RN, Casey N, Evans-Molina C, Sims EK, Spaeth JM |
Diabetes | 2023 |
Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells
Karagiannopoulos A, Westholm E, Ofori JK, Cowan E, Esguerra JL, Eliasson L |
iScience | 2023 |
EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretion
Blanchi B, Taurand M, Colace C, Thomaidou S, Audeoud C, Fantuzzi F, Sawatani T, Gheibi S, Sabadell-Basallote J, Boot FW, Chantier T, Piet A, Cavanihac C, Pilette M, Balguerie A, Olleik H, Carlotti F, Ejarque M, Fex M, Mulder H, Cnop M, Eizirik DL, Jouannot O, Gaffuri AL, Czernichow P, Zaldumbide A, Scharfmann R, Ravassard P |
Molecular Metabolism | 2023 |
IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.
Thomaidou S, Munoz Garcia A, de Lange S, Gan J, van der Slik AR, Hoeben RC, Roep BO, Carlotti F, Zaldumbide A |
Diabetologia | 2023 |
LncRNA ARGI Contributes to Virus‐Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN‐Stimulated Genes
González\u2010Moro I, Garcia\u2010Etxebarria K, Mendoza LM, Fernández\u2010Jiménez N, Mentxaka J, Olazagoitia\u2010Garmendia A, Arroyo MN, Sawatani T, Moreno\u2010Castro C, Vinci C, Op de Beek A, Cnop M, Igoillo\u2010Esteve M, Santin I |
Advanced Science | 2023 |
Platelet‐derived lipids promote insulin secretion of pancreatic β cells
Karwen T, Kolczynska\u2010Matysiak K, Gross C, Löffler MC, Friedrich M, Loza\u2010Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo\u2010Viera J, El\u2010Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G |
EMBO Molecular Medicine | 2023 |
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Torres JM, Sun H, Nylander V, Downes DJ, van de Bunt M, McCarthy MI, Hughes JR, Gloyn AL |
Wellcome Open Research | 2023 |
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells.
Torres JM, Sun H, Nylander V, Downes DJ, van de Bunt M, McCarthy MI, Hughes JR, Gloyn AL |
Wellcome Open Research | 2023 |
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
Lau HH, Krentz NA, Abaitua F, Perez-Alcantara M, Chan JW, Ajeian J, Ghosh S, Lee Y, Yang J, Thaman S, Champon B, Sun H, Jha A, Hoon S, Tan NS, Gardner DS, Kao SL, Tai ES, Gloyn AL, Teo AK |
Nature Communications | 2023 |
Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human EndoC-βH1 β-cells against proinflammatory insults
Dos Santos RS, Guzman-Llorens D, Perez-Serna AA, Nadal A, Marroqui L |
Frontiers in immunology | 2023 |
The beta cell-immune cell interface in type 1 diabetes (T1D)
James EA, Joglekar AV, Linnemann AK, Russ HA, Kent SC |
Molecular Metabolism | 2023 |
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression
Pasquier A, Pastore N, D'Orsi L, Colonna R, Esposito A, Maffia V, De Cegli R, Mutarelli M, Ambrosio S, Tufano G, Grimaldi A, Cesana M, Cacchiarelli D, Delalleau N, Napolitano G, Ballabio A |
The EMBO Journal | 2023 |
Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model
Jaffredo M, Krentz NA, Champon B, Duff CE, Nawaz S, Beer N, Honore C, Clark A, Rorsman P, Lang J, Gloyn AL, Raoux M, Hastoy B |
2023 | |
Apolipoprotein L genes are novel mediators of inflammation in beta cells.
Paz-Barba M, Muñoz Garcia A, de Winter TJJ, de Graaf N, van Agen M, van der Sar E, Lambregtse F, Daleman L, van der Slik A, Zaldumbide A, de Koning EJP, Carlotti F |
Diabetologia | 2023 |
Harnessing Human Pluripotent Stem Cell-Derived Pancreatic In Vitro Models for High-Throughput Toxicity Testing and Diabetes Drug Discovery.
Ching C, Iich E, Teo AKK |
Handbook of experimental pharmacology | 2023 |
Human fetal tissue is critical for biomedical research
Brumbaugh J, Aguado BA, Lysaght T, Goldstein LS |
Stem Cell Reports | 2023 |
Proinflammatory Cytokines, but not Glucolipotoxicity, Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells.
Ghiasi SM, Marchetti P, Piemonti L, Nielsen JH, Porse BT, Mandrup-Poulsen T, Rutter GA |
bioRxiv : the preprint server for biology | 2023 |
Stress-induced β-cell early senescence confers protection against type 1 diabetes
Lee H, Sahin GS, Chen CW, Sonthalia S, Cañas SM, Oktay HZ, Duckworth AT, Brawerman G, Thompson PJ, Hatzoglou M, Eizirik DL, Engin F |
Cell Metabolism | 2023 |
Control of human pancreatic beta cell kinome by glucagon‐like peptide‐1 receptor biased agonism
Xiao J, El Eid L, Buenaventura T, Boutry R, Bonnefond A, Jones B, Rutter GA, Froguel P, Tomas A |
Diabetes, obesity & metabolism | 2023 |
Glucose-Dependent miR-125b is a Negative Regulator of β-Cell Function
R Cheung, G Pizza, P Chabosseau, D Rolando, A Tomas, T Burgoyne, Z Wu, A Salowka, A Tapa, A Macklin, Y Cao, M Nguyen-Tu, M Dickerson, D Jacobson, P Marchetti, J Shapiro, L Piemonti, E de Koning, I Leclerc, K Bouzakri, K Sakamoto, D Smith, G Rutter, A Martinez-Sanchez |
Diabetes | 2022 |
Islet Gene View - a tool to facilitate islet research
Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi Prasad |
Life science alliance | 2022 |
Stem Cell-Derived Islets for Type 2 Diabetes
A Salib, F Cayabyab, E Yoshihara |
International journal of molecular sciences | 2022 |
Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction
A Bartolomé |
International journal of molecular sciences | 2022 |
The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions
M Brown, D Laouteouet, M Delobel, O Villard, C Broca, G Bertrand, A Wojtusciszyn, S Dalle, M Ravier, A Matveyenko, S Costes |
Cell Death and Disease | 2022 |
Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
E Shcheglova, K Blaszczyk, M Borowiak |
Frontiers in Cell and Developmental Biology | 2022 |
Characterization of the Secretome, Transcriptome, and Proteome of Human β Cell Line EndoC-βH1
M Ryaboshapkina, K Saitoski, G Hamza, A Jarnuczak, S Pechberty, C Berthault, K Sengupta, C Underwood, S Andersson, R Scharfmann |
Molecular & cellular proteomics : MCP | 2022 |
Quantification of Unmethylated Insulin DNA Using Methylation Sensitive Restriction Enzyme Digital Polymerase Chain Reaction
F van de Leemkolk, R Nell, M Versluis, E de Koning, V Huurman, I Alwayn, R Ploeg, P van der Velden, M Engelse |
Transplant international : official journal of the European Society for Organ Transplantation | 2022 |
High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets
H MacMillan, Y Kong, E Calvo-Roitberg, L Alonso, A Pai |
Scientific Reports | 2022 |
NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes
P Xiao, T Takiishi, N Violato, G Licata, F Dotta, G Sebastiani, L Marselli, S Singh, M Sze, G Loo, E Dejardin, E Gurzov, A Cardozo |
Cell Death and Disease | 2022 |
Loss of Human Beta Cell Identity in a Reconstructed Omental Stromal Cell Environment
B Secco, K Saitoski, K Drareni, A Soprani, S Pechberty, L Rachdi, N Venteclef, R Scharfmann |
Cells | 2022 |
Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic β-Cells: Evaluation of Murine and Human In Vitro Models
R Al-Abdulla, H Ferrero, S Soriano, T Boronat-Belda, P Alonso-Magdalena |
International journal of molecular sciences | 2022 |
In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model
R Santos, R Medina-Gali, I Babiloni-Chust, L Marroqui, A Nadal |
International journal of molecular sciences | 2022 |
Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells
Dettmer R, Niwolik I, Cirksena K, Yoshimoto T, Tang Y, Mehmeti I, Gurgul-Convey E, Naujok O |
Diabetologia | 2022 |
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan A, Spracklen CN, Zhang W, Ng MC, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Parolo PD, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJ, Tam CH, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JC, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam T, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen ME, Jørgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schönherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stančáková A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Hanis CL, Peyser PA, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Zeggini E, Yokota M, Rich SS, Kooperberg C, Pankow JS, Engert JC, Chen YD, Froguel P, Wilson JG, Sheu WH, Kardia SL, Wu JY, Hayes MG, Ma RC, Wong TY, Groop L, Mook-Kanamori DO, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, McKean-Cowdin R, Grallert H, Cheng CY, Bottinger EP, Dehghan A, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Palmer CN, Liu S, Abecasis G, Kooner JS, Loos RJ, North KE, Haiman CA, Florez JC, Saleheen D, Hansen T, Pedersen O, Mägi R, Langenberg C, Wareham NJ, Maeda S, Kadowaki T, Lee J, Millwood IY, Walters RG, Stefansson K, Myers SR, Ferrer J, Gaulton KJ, Meigs JB, Mohlke KL, Gloyn AL, Bowden DW, Below JE, Chambers JC, Sim X, Boehnke M, Rotter JI, McCarthy MI, Morris AP |
Nature Genetics | 2022 |
Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
Golec E, Ekström A, Noga M, Omar-Hmeadi M, Lund PE, Villoutreix BO, Krus U, Wozniak K, Korsgren O, Renström E, Barg S, King BC, Blom AM |
Proceedings of the National Academy of Sciences | 2022 |
ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells.
Hagenlocher C, Siebert R, Taschke B, Wieske S, Hausser A, Rehm M |
Cell Death Discovery | 2022 |
DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism
Chatterjee Bhowmick D, Aslamy A, Bhattacharya S, Oh E, Ahn M, Thurmond DC |
Diabetes | 2022 |
Temporal regulation of interferon signalling in human EndoC-βH1 cells
Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG |
Journal of molecular endocrinology | 2022 |
Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells
Noordstra I, van den Berg CM, Boot FW, Katrukha EA, Yu KL, Tas RP, Portegies S, Viergever BJ, de Graaff E, Hoogenraad CC, de Koning EJ, Carlotti F, Kapitein LC, Akhmanova A |
Journal of cell science | 2022 |
Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion
Szczerbinska I, Tessitore A, Hansson LK, Agrawal A, Ragel Lopez A, Helenius M, Malinowski AR, Gilboa B, Ruby MA, Gupta R, Ämmälä C |
Biomedicines | 2022 |
Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells
Thomas P, Arden C, Corcoran J, Hacker C, Welters HJ, Morgan NG |
Nutrition & Diabetes | 2022 |
Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits
Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R |
The Journal of biological chemistry | 2022 |
Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation
Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F |
Cell Death Discovery | 2022 |
The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function
Davidson RK, Weaver SA, Casey N, Kanojia S, Hogarth E, Aguirre RS, Sims EK, Evans-Molina C, Spaeth JM |
Journal of molecular endocrinology | 2022 |
Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
Moon S, Jung HS |
Diabetes & Metabolism Journal | 2022 |
Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells
Bulfoni M, Bouyioukos C, Zakaria A, Nigon F, Rapone R, Del Maestro L, Ait-Si-Ali S, Scharfmann R, Cosson B |
Frontiers in Endocrinology | 2022 |
In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo
Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M |
Frontiers in Cell and Developmental Biology | 2022 |
Treating iPSC-Derived β Cells with an Anti-CD30 Antibody-Drug Conjugate Eliminates the Risk of Teratoma Development upon Transplantation.
Pellegrini S, Zamarian V, Landi E, Cospito A, Lombardo MT, Manenti F, Citro A, Schiavo Lena M, Piemonti L, Sordi V |
International journal of molecular sciences | 2022 |
ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis
Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A |
Frontiers in Endocrinology | 2022 |
Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.
Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL |
Science Advances | 2022 |
The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse β-Cells
Martins Peçanha FL, Jaafar R, Werneck-de-Castro JP, Apostolopolou CC, Bhushan A, Bernal-Mizrachi E |
Diabetes | 2022 |
The highly expressed calcium‐insensitive synaptotagmin‐11 and synaptotagmin‐13 modulate insulin secretion
Ofori JK, Karagiannopoulos A, Barghouth M, Nagao M, Andersson ME, Salunkhe VA, Zhang E, Wendt A, Eliasson L |
Acta physiologica (Oxford, England) | 2022 |
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.
Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F |
Non-Coding RNA | 2022 |
Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies.
Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL |
iScience | 2022 |
The human batokine EPDR1 regulates β-cell metabolism and function
Cataldo LR, Gao Q, Argemi-Muntadas L, Hodek O, Cowan E, Hladkou S, Gheibi S, Spégel P, Prasad RB, Eliasson L, Scheele C, Fex M, Mulder H, Moritz T |
Molecular Metabolism | 2022 |
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding
Alghamdi TA, Krentz NA, Smith N, Spigelman AF, Rajesh V, Jha A, Ferdaoussi M, Suzuki K, Yang J, Manning Fox JE, Sun H, Sun Z, Gloyn AL, MacDonald PE |
Molecular Metabolism | 2022 |
Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.
Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL |
Diabetologia | 2022 |
ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation
Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A |
Frontiers in Endocrinology | 2022 |
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.
Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL |
Nature Genetics | 2022 |
Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Guo Z, Kasinathan D, Merriman C, Nakayama M, Li H, Li H, Xu C, Wong GW, Yu L, Golson ML, Fu D |
Diabetes | 2022 |
Experimental Approaches to Diabetes Mellitus
Yayla M, Binnetoğlu D |
The Eurasian Journal of Medicine | 2022 |
RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression
L Regué, L Zhao, F Ji, H Wang, J Avruch, N Dai |
Molecular Metabolism | 2021 |
Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress
N Groen, F Leenders, A Mahfouz, A Munoz-Garcia, MJ Muraro, N de Graaf, TJ Rabelink, R Hoeben, A van Oudenaarden, A Zaldumbide, MJ Reinders, EJ de Koning, F Carlotti |
Cells | 2021 |
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
M Hu, I Cebola, G Carrat, S Jiang, S Nawaz, A Khamis, M Canouil, P Froguel, A Schulte, M Solimena, M Ibberson, P Marchetti, FL Cardenas-Diaz, PJ Gadue, B Hastoy, L Alemeida-Souza, H McMahon, GA Rutter |
Cell Reports | 2021 |
The Human Islet: Mini-Organ With Mega-Impact
JT Walker, DC Saunders, M Brissova, AC Powers |
Endocrine reviews | 2021 |
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells
BS Low, CS Lim, SS Ding, YS Tan, NH Ng, VG Krishnan, SF Ang, CW Neo, CS Verma, S Hoon, SC Lim, ES Tai, AK Teo |
Nature Communications | 2021 |
Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies
A Mooranian, M Jones, CM Ionescu, D Walker, SR Wagle, B Kovacevic, J Chester, T Foster, E Johnston, M Mikov, H Al-Salami |
Nanomaterials | 2021 |
Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity
F Leenders, N Groen, N de Graaf, MA Engelse, TJ Rabelink, EJ de Koning, F Carlotti |
Frontiers in immunology | 2021 |
Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative
M de Fátima Brito, C Torre, B Silva-Lima |
Frontiers in Medicine | 2021 |
The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis
M Ramos-Rodríguez, B Pérez-González, L Pasquali |
Current Diabetes Reports | 2021 |
Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death
P Thomas, KA Leslie, HJ Welters, NG Morgan |
Nutrition & Metabolism | 2021 |
Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells
EM MacFarlane, JE Bruin |
Frontiers in Endocrinology | 2021 |
Regulation of ATR-dependent DNA damage response by nitric oxide
CT Yeo, JS Stancill, BJ Oleson, JK Schnuck, JD Stafford, A Naatz, PA Hansen, JA Corbett |
The Journal of biological chemistry | 2021 |
CD81 marks immature and dedifferentiated pancreatic β-cells
C Salinno, M Büttner, P Cota, S Tritschler, M Tarquis-Medina, A Bastidas-Ponce, K Scheibner, I Burtscher, A Böttcher, FJ Theis, M Bakhti, H Lickert |
Molecular Metabolism | 2021 |
Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ
R Veluthakal, E Oh, M Ahn, DC Bhowmick, DC Thurmond |
Diabetes | 2021 |
Human Pluripotent Stem Cells to Model Islet Defects in Diabetes
D Balboa, DG Iworima, TJ Kieffer |
Frontiers in Endocrinology | 2021 |
Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
AC de Brachène, A Castela, AE Musuaya, L Marselli, P Marchetti, DL Eizirik |
Autoimmunity Highlights | 2021 |
Insulinoma-derived pseudo-islets for diabetes research
NJ Hart, C Weber, N Price, A Banuelos, M Schultz, B Huey, E Harnois, C Gibson, LV Steyn, KK Papas, RM Lynch |
American journal of physiology. Cell physiology | 2021 |
Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
X Jian, G Felsenfeld |
Nature Communications | 2021 |
ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation
X Wang, S Younis, J Cen, Y Wang, C Krizhanovskii, L Andersson, N Welsh |
Diabetologia | 2021 |
Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection
JR Chaffey, J Young, KA Leslie, K Partridge, P Akhbari, S Dhayal, JL Hill, KC Wedgwood, E Burnett, MA Russell, SJ Richardson, NG Morgan |
Scientific Reports | 2021 |
Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
Y Tang, T Plötz, MH Gräler, E Gurgul-Convey |
International journal of molecular sciences | 2021 |
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion
N Vishnu, A Hamilton, A Bagge, A Wernersson, E Cowan, H Barnard, Y Sancak, KJ Kamer, P Spégel, M Fex, A Tengholm, VK Mootha, DG Nicholls, H Mulder |
Molecular Metabolism | 2021 |
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
H Lin, Y Yan, Y Luo, WY So, X Wei, X Zhang, X Yang, J Zhang, Y Su, X Yang, B Zhang, K Zhang, N Jiang, BK Chow, W Han, F Wang, F Rao |
Nature Communications | 2021 |
A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis
MI Alvelos, F Szymczak, Â Castela, S Marín-Cañas, BM de Souza, I Gkantounas, M Colli, F Fantuzzi, C Cosentino, M Igoillo-Esteve, L Marselli, P Marchetti, M Cnop, DL Eizirik |
Islets | 2021 |
Found in Translation: Novel Insights Into Type 1 Diabetes and β-Cell Biology
HA Russ, HW Davidson |
Diabetes | 2021 |
Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion
A Zakaria, C Berthault, B Cosson, V Jung, IC Guerrera, L Rachdi, R Scharfmann |
The Journal of biological chemistry | 2021 |
Butyrate Protects Pancreatic Beta Cells from Cytokine-Induced Dysfunction
M Prause, SS Pedersen, V Tsonkova, M Qiao, N Billestrup |
International journal of molecular sciences | 2021 |
Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
SN Gharavy, BM Owen, SJ Millership, P Chabosseau, G Pizza, A Martinez-Sanchez, E Tasoez, E Georgiadou, M Hu, NH Fine, DA Jacobson, MT Dickerson, O Idevall-Hagren, A Montoya, H Kramer, Z Mehta, DJ Withers, N Ninov, PJ Gadue, FL Cardenas-Diaz, C Cruciani-Guglielmacci, C Magnan, M Ibberson, I Leclerc, M Voz, GA Rutter |
Diabetologia | 2021 |
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans
AR Sánchez-Archidona, C Cruciani-Guglielmacci, C Roujeau, L Wigger, J Lallement, J Denom, M Barovic, N Kassis, F Mehl, J Weitz, M Distler, C Klose, K Simons, M Ibberson, M Solimena, C Magnan, B Thorens |
Molecular Metabolism | 2021 |
Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice
S Erener, CE Ellis, A Ramzy, MM Glavas, S ODwyer, S Pereira, T Wang, J Pang, JE Bruin, MJ Riedel, RK Baker, TD Webber, M Lesina, M Blüher, H Algül, JL Kopp, S Herzig, TJ Kieffer |
Cell reports. Medicine | 2021 |
Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells
S Kahraman, D Manna, E Dirice, B Maji, J Small, BK Wagner, A Choudhary, RN Kulkarni |
Life science alliance | 2021 |
Reagents and models for detecting endogenous GLP1R and GIPR
J Ast, J Broichhagen, DJ Hodson |
EBioMedicine | 2021 |
Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation
A Mooranian, M Jones, CM Ionescu, D Walker, SR Wagle, B Kovacevic, J Chester, T Foster, E Johnston, J Kuthubutheen, D Brown, M Mikov, H Al-Salami |
Journal of Functional Biomaterials | 2021 |
Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells
Elksnis A, Cen J, Wikström P, Carlsson PO, Welsh N |
Biomedicines | 2021 |
Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion
Ofori JK, Karagiannopoulos A, Nagao M, Westholm E, Ramadan S, Wendt A, Esguerra JL, Eliasson L |
Diabetes | 2021 |
YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress
Elisa De Franco, Maria Lytrivi, Hazem Ibrahim, Hossam Montaser, Matthew Wakeling, Federica Fantuzzi, Kashyap A. Patel, Céline Demarez, Ying Cai, Mariana Igoillo-Esteve, Cristina Cosentino, Väinö Lithovius, Helena Vihinen, Eija Jokitalo, Thomas Laver, Matthew B Johnson, Toshiaki Sawatani, Hadis Shakeri, Nathalie Pachera, Belma Haliloglu, Mehmet Ozbek, Edip Unal, Ruken Yıldırım, Tushar Godbole, Melek Yildiz, Banu Aydin, Angeline Bilheu, Ikuo K. Suzuki, Sarah E Flanagan, Pierre Vanderhaeghen, Valérie Senée, Cécile Julier, Piero Marchetti, Decio L. Eizirik, Sian Ellard, Jonna Saarimäki-Vire, Timo Otonkoski, Miriam Cnop, Andrew T. Hattersley |
Journal of Clinical Investigation | 2020 |
Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Mariana Igoillo-Esteve, Ana F Oliveira, Cristina Cosentino, Federica Fantuzzi, Céline Demarez, Sanna Toivonen, Amélie Hu, Satyan Chintawar, Miguel Lopes, Nathalie Pachera, Ying Cai, Baroj Abdulkarim, Myriam Rai, Lorella Marselli, Piero Marchetti, Mohammad Tariq, Jean-Christophe Jonas, Marina Boscolo, Massimo Pandolfo, Decio Eizirik, Miriam Cnop |
JCI Insight | 2020 |
Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets
L Rachdi, A Maugein, S Pechberty, M Armanet, J Hamroune, P Ravassard, S Marullo, O Albagli, R Scharfmann |
Scientific Reports | 2020 |
The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis
GR Carrat, E Haythorne, A Tomas, L Haataja, A Müller, P Arvan, A Piunti, K Cheng, M Huang, TJ Pullen, E Georgiadou, T Stylianides, NS Amirruddin, V Salem, W Distaso, A Cakebread, KJ Heesom, PA Lewis, DJ Hodson, LJ Briant, AC Fung, RB Sessions, F Alpy, AP Kong, PI Benke, F Torta, AK Teo, I Leclerc, M Solimena, DB Wigley, GA Rutter |
Molecular Metabolism | 2020 |
Aberrant methylation underlies insulin gene expression in human insulinoma
E Karakose, H Wang, W Inabnet, RV Thakker, S Libutti, G Fernandez-Ranvier, H Suh, M Stevenson, Y Kinoshita, M Donovan, Y Antipin, Y Li, X Liu, F Jin, P Wang, A Uzilov, C Argmann, EE Schadt, AF Stewart, DK Scott, L Lambertini |
Nature Communications | 2020 |
Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival
R Hu, E Walker, C Huang, Y Xu, C Weng, GE Erickson, A Coldren, X Yang, M Brissova, I Kaverina, BN Appakalai, CV Wright, Y Li, R Stein, G Gu |
Developmental Cell | 2020 |
Modeling different types of diabetes using human pluripotent stem cells
EM Abdelalim |
Cellular and Molecular Life Sciences | 2020 |
Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
ES Nakayasu, F Syed, SA Tersey, MA Gritsenko, HD Mitchell, CY Chan, E Dirice, JV Turatsinze, Y Cui, RN Kulkarni, DL Eizirik, WJ Qian, BJ Webb-Robertson, C Evans-Molina, RG Mirmira., TO Metz |
Cell Metabolism | 2020 |
A Dual Reporter EndoC-βH1 Human β-Cell Line for Efficient Quantification of Calcium Flux and Insulin Secretion
FL Cardenas-Diaz, KF Leavens, S Kishore, C Osorio-Quintero, YJ Chen, BZ Stanger, P Wang, D French, P Gadue |
Endocrinology | 2020 |
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics
NA Krentz, AL Gloyn |
Nature Reviews Endocrinology | 2020 |
Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA
JL Esguerra, JK Ofori, M Nagao, Y Shuto, A Karagiannopoulos, J Fadista, H Sugihara, L Groop, L Eliasson |
Molecular Metabolism | 2020 |
Toxicity of fatty acid profiles of popular edible oils in human EndoC-βH1 beta-cells
AS von Hanstein, S Lenzen, T Plötz |
Nutrition and Diabetes | 2020 |
Establishment of A Reversibly Inducible Porcine Granulosa Cell Line
Y Bai, C Zhu, M Feng, B Pan, S Zhang, X Zhan, H Chen, B Wang, J Li |
Cells | 2020 |
Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
M Nagao, JL Esguerra, A Asai, JK Ofori, A Edlund, A Wendt, H Sugihara, CB Wollheim, S Oikawa, L Eliasson |
Diabetes | 2020 |
Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project
K Audouze, D Sarigiannis, P Alonso-Magdalena, C Brochot, M Casas, M Vrijheid, PJ Babin, S Karakitsios, X Coumoul, R Barouki |
International journal of molecular sciences | 2020 |
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes
AC de Brachène, A Castela, AO de Beeck, RG Mirmira, L Marselli, P Marchetti, C Masse, W Miao, S Leit, C EvansMolina, DL Eizirik |
Diabetes, obesity & metabolism | 2020 |
Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals
A Wesolowska-Andersen, GZ Yu, V Nylander, F Abaitua, M Thurner, JM Torres, A Mahajan, AL Gloyn, MI McCarthy |
eLife | 2020 |
MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling
H Mziaut, G Henniger, K Ganss, S Hempel, S Wolk, J McChord, K Chowdhury, P Ravassard, KP Knoch, C Krautz, J Weitz, R Grützmann, C Pilarsky, M Solimena, S Kersting |
Molecular Metabolism | 2020 |
Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells
F Xu, J Liu, L Na, L Chen |
Frontiers in Cell and Developmental Biology | 2020 |
Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells
C Berthault, W Staels, R Scharfmann |
Molecular Metabolism | 2020 |
A Toolbox for Translational Research on Beta Cell Function
T Schulze, I Rustenbeck |
Endocrinology | 2020 |
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
A Viñuela, A Varshney, M van de Bunt, RB Prasad, O Asplund, A Bennett, M Boehnke, AA Brown, MR Erdos, J Fadista, O Hansson, G Hatem, C Howald, AK Iyengar, P Johnson, U Krus, PE MacDonald, A Mahajan, JE Fox, N Narisu, V Nylander, P Orchard, N Oskolkov, NI Panousis, A Payne, ML Stitzel, S Vadlamudi, R Welch, FS Collins, KL Mohlke, AL Gloyn, LJ Scott, ET Dermitzakis, L Groop, SC Parker, MI McCarthy |
Nature Communications | 2020 |
Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells
E Gurgul-Convey |
Cells | 2020 |
Effects of Polyphenols on Insulin Resistance
G Williamson, K Sheedy |
Nutrients | 2020 |
Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress
T Ishibashi, S Morita, S Kishimoto, S Uraki, K Takeshima, Y Furukawa, H Inaba, H Ariyasu, H Iwakura, H Furuta, M Nishi, FR Papa, T Akamizu |
Journal of Diabetes Investigation | 2020 |
Production and Characterization of a Conditionally Immortalized Dog Beta-Cell Line from Fetal Canine Pancreas
P Czernichow, K Reynaud, P Ravassard |
Cell Transplantation | 2020 |
A requirement for pak1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis
M Ahn, E Oh, EM McCown, X Wang, R Veluthakal, DC Thurmond |
Metabolism | 2020 |
SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature
D Fignani, G Licata, N Brusco, L Nigi, GE Grieco, L Marselli, L Overbergh, C Gysemans, ML Colli, P Marchetti, C Mathieu, DL Eizirik, G Sebastiani, F Dotta |
Frontiers in Endocrinology | 2020 |
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
ML Colli, M Ramos-Rodríguez, ES Nakayasu, MI Alvelos, M Lopes, JL Hill, JV Turatsinze, AC de Brachène, MA Russell, H Raurell-Vila, A Castela, J Juan-Mateu, BJ Webb-Robertson, L Krogvold, K Dahl-Jorgensen, L Marselli, P Marchetti, SJ Richardson, NG Morgan, TO Metz, L Pasquali, DL Eizirik |
Nature Communications | 2020 |
Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research
M Hu, I Cherkaoui, S Misra, GA Rutter |
Frontiers in Endocrinology | 2020 |
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells
MI Alvelos, M Brüggemann, FX Sutandy, J Juan-Mateu, ML Colli, A Busch, M Lopes, Â Castela, A Aartsma-Rus, J König, K Zarnack, DL Eizirik |
Life science alliance | 2020 |
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function
Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL |
Wellcome Open Research | 2020 |
iPreP: A three-dimensional nanofibrillar cellulose hydrogel platform for long-term ex vivo preservation of human islets
Yi-Ju Chen, Taiji Yamazoe, Karla Leavens, Fabian L. Cardenas-Diaz, Andrei Georgescu, Dongeun Huh, Paul Gadue, Ben Stanger |
JCI Insight | 2019 |
The supply chain of human pancreatic beta cell lines
Raphaël Scharfmann, Willem Staels, Olivier Albagli-Curiel |
Journal of Clinical Investigation | 2019 |
m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes
DF Jesus, Z Zhang, S Kahraman, NK Brown, M Chen, J Hu, MK Gupta, C He, RN Kulkarni |
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Genome editing of human pancreatic beta cell models: problems, possibilities and outlook
D Balboa, RB Prasad, L Groop, T Otonkoski |
Diabetologia | 2019 |
A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration
Y Wang, S Chen, Z Yan, M Pei |
Cell & Bioscience | 2019 |
MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
K Tyka, A Jörns, JV Turatsinze, DL Eizirik, S Lenzen, E Gurgul-Convey |
Cell Death and Disease | 2019 |
Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function
N Lawlor, EJ Márquez, P Orchard, N Narisu, MS Shamim, A Thibodeau, A Varshney, R Kursawe, MR Erdos, M Kanke, H Gu, E Pak, A Dutra, S Russell, X Li, E Piecuch, O Luo, PS Chines, C Fuchbserger, P Sethupathy, AP Aiden, Y Ruan, EL Aiden, FS Collins, D Ucar, SC Parker, ML Stitzel |
Cell Reports | 2019 |
A Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells
L Yi, CF Tsai, E Dirice, AC Swensen, J Chen, T Shi, MA Gritsenko, RK Chu, PD Piehowski, RD Smith, KD Rodland, MA Atkinson, CE Mathews, RN Kulkarni, T Liu, WJ Qian |
Analytical Chemistry | 2019 |
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
A Castellanos-Rubio, I Santin, A Olazagoitia-Garmendia, I Romero-Garmendia, A Jauregi-Miguel, M Legarda, JR Bilbao |
Scientific Reports | 2019 |
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
S Vig, M Buitinga, D Rondas, I Crèvecoeur, M van Zandvoort, E Waelkens, DL Eizirik, C Gysemans, P Baatsen, C Mathieu, L Overbergh |
Cell Death and Disease | 2019 |
Pancreatic β-cells detoxify H 2 O 2 through the peroxiredoxin/thioredoxin antioxidant system
JS Stancill, KA Broniowska, BJ Oleson, A Naatz, JA Corbett |
The Journal of biological chemistry | 2019 |
ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor
PL Toledo, JM Torkko, A Müller, C Wegbrod, A Sönmez, M Solimena, MR Ermácora |
The Journal of biological chemistry | 2019 |
Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
ML Colli, FM Paula, L Marselli, P Marchetti, M Roivainen, DL Eizirik, AO de beeck |
Journal of Innate Immunity | 2019 |
Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension
M Baron, J Maillet, M Huyvaert, A Dechaume, R Boutry, H Loiselle, E Durand, B Toussaint, E Vaillant, J Philippe, J Thomas, A Ghulam, S Franc, G Charpentier, JM Borys, C Lévy-Marchal, M Tauber, R Scharfmann, J Weill, C Aubert, J Kerr-Conte, F Pattou, R Roussel, B Balkau, M Marre, M Boissel, M Derhourhi, S Gaget, M Canouil, P Froguel, A Bonnefond |
Nature Medicine | 2019 |
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
C Merriman, D Fu |
The Journal of biological chemistry | 2019 |
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
OP Dwivedi, M Lehtovirta, B Hastoy, V Chandra, NA Krentz, S Kleiner, D Jain, AM Richard, F Abaitua, NL Beer, A Grotz, RB Prasad, O Hansson, E Ahlqvist, U Krus, I Artner, A Suoranta, D Gomez, A Baras, B Champon, AJ Payne, D Moralli, SK Thomsen, P Kramer, I Spiliotis, R Ramracheya, P Chabosseau, A Theodoulou, R Cheung, M van de Bunt, J Flannick, M Trombetta, E Bonora, CB Wolheim, L Sarelin, RC Bonadonna, P Rorsman, B Davies, J Brosnan, MI McCarthy, T Otonkoski, JO Lagerstedt, GA Rutter, J Gromada, AL Gloyn, T Tuomi, L Groop |
Nature Genetics | 2019 |
Production, Characterization, and Function of Pseudoislets from Perinatal Canine Pancreas
P Czernichow, K Reynaud, J Kerr-Conte, E Furthner, P Ravassard |
Cell Transplantation | 2019 |
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
M Oshima, S Pechberty, L Bellini, SO Göpel, M Campana, C Rouch, J Dairou, C Cosentino, F Fantuzzi, S Toivonen, P Marchetti, C Magnan, M Cnop, HL Stunff, R Scharfmann |
Diabetologia | 2019 |
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
M Ramos-Rodríguez, H Raurell-Vila, ML Colli, MI Alvelos, M Subirana-Granés, J Juan-Mateu, R Norris, JV Turatsinze, ES Nakayasu, BJ Webb-Robertson, JR Inshaw, P Marchetti, L Piemonti, M Esteller, JA Todd, TO Metz, DL Eizirik, L Pasquali |
Nature Genetics | 2019 |
A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice
S Demine, RG Ribeiro, J Thevenet, L Marselli, P Marchetti, F Pattou, J Kerr-Conte, N Devoogdt, DL Eizirik |
Diabetologia | 2019 |
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function
AK Grotz, F Abaitua, E Navarro-Guerrero, B Hastoy, D Ebner, AL Gloyn |
Wellcome Open Research | 2019 |
The miRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells
FA Grieco, AA Schiavo, F Brozzi, J Juan-Mateu, M Bugliani, P Marchetti, DL Eizirik |
Journal of Molecular Endocrinology | 2019 |
Viral like infection induces Human β cell dedifferentiation
Masaya OSHIMA, Klaus-Peter Knoch, Marc Diedisheim, Antje PETZOLD, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo Huang, Stefan Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphaël Scharfmann |
JCI Insight | 2018 |
Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
S Culina, AI Lalanne, G Afonso, K Cerosaletti, S Pinto, G Sebastiani, K Kuranda, L Nigi, A Eugster, T Østerbye, A Maugein, JE McLaren, K Ladell, E Larger, JP Beressi, A Lissina, V Appay, HW Davidson, S Buus, DA Price, M Kuhn, E Bonifacio, M Battaglia, S Caillat-Zucman, F Dotta, R Scharfmann, B Kyewski, R Mallone |
Science Immunology | 2018 |
MAFA missense mutation causes familial insulinomatosis and diabetes mellitus
D Iacovazzo, SE Flanagan, E Walker, R Quezado, FA de Barros, R Caswell, MB Johnson, M Wakeling, M Brändle, M Guo, MN Dang, P Gabrovska, B Niederle, E Christ, S Jenni, B Sipos, M Nieser, A Frilling, K Dhatariya, P Chanson, WW de Herder, B Konukiewitz, G Klöppel, R Stein, M Korbonits, S Ellard |
Proceedings of the National Academy of Sciences | 2018 |
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
S Tunaru, R Bonnavion, I Brandenburger, J Preussner, D Thomas, K Scholich, S Offermanns |
Nature Communications | 2018 |
(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives
L Baeyens, M Lemper, W Staels, SD Groef, ND Leu, Y Heremans, MS German, H Heimberg |
Physiological reviews | 2018 |
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
B Hastoy, M Godazgar, A Clark, V Nylander, I Spiliotis, M van de Bunt, MV Chibalina, A Barrett, C Burrows, AI Tarasov, R Scharfmann, AL Gloyn, P Rorsman |
Scientific Reports | 2018 |
Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
E Oh, M Ahn, S Afelik, TC Becker, BO Roep, DC Thurmond |
Diabetes | 2018 |
Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients
S Skrtic, B Tyrberg, M Broberg, H Ericsson, V Schnecke, M Kjaer, M Hompesch, EM Andersson, E Ryberg, A Aivazidis, CW Huldt, L Löfgren, L Morrow, J Parkinson, T Rydén-Bergsten, E Watkins, MS Winzell, E Barengolts |
PloS one | 2018 |
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes
C Cosentino, S Toivonen, ED Villamil, M Atta, JL Ravanat, S Demine, AA Schiavo, N Pachera, JP Deglasse, JC Jonas, D Balboa, T Otonkoski, ER Pearson, P Marchetti, DL Eizirik, M Cnop, M Igoillo-Esteve |
Nucleic Acids Research | 2018 |
Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca 2+ Sensitivity of Insulin Secretion Vesicles
C Huang, EM Walker, PK Dadi, R Hu, Y Xu, W Zhang, T Sanavia, J Mun, J Liu, GG Nair, HY Tan, S Wang, MA Magnuson, CJ Stoeckert, M Hebrok, M Gannon, W Han, R Stein, DA Jacobson, G Gu |
Developmental Cell | 2018 |
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
SK Thomsen, A Raimondo, B Hastoy, S Sengupta, XQ Dai, A Bautista, J Censin, AJ Payne, MM Umapathysivam, AF Spigelman, A Barrett, CJ Groves, NL Beer, JE Fox, MI McCarthy, A Clark, A Mahajan, P Rorsman, PE MacDonald, AL Gloyn |
Nature Genetics | 2018 |
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans
C Izzi-Engbeaya, AN Comninos, SA Clarke, A Jomard, L Yang, S Jones, A Abbara, S Narayanaswamy, PC Eng, D Papadopoulou, JK Prague, P Bech, IF Godsland, P Bassett, C Sands, S Camuzeaux, M Gomez-Romero, JT Pearce, MR Lewis, E Holmes, JK Nicholson, T Tan, R Ratnasabapathy, M Hu, G Carrat, L Piemonti, M Bugliani, P Marchetti, PR Johnson, SJ Hughes, AM Shapiro, GA Rutter, WS Dhillo |
Diabetes, obesity & metabolism | 2018 |
Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction
SF Hansson, AX Zhou, P Vachet, JW Eriksson, MJ Pereira, S Skrtic, HJ Wallin, A Ericsson-Dahlstrand, D Karlsson, A Ahnmark, MS Winzell, MC Magnone, P Davidsson, P Fiorina |
PloS one | 2018 |
Porcine Neonatal Pancreatic Cell Clusters Maintain Their Multipotency in Culture and After Transplantation
WC Li, CY Chen, CW Kao, PC Huang, YT Hsieh, TY Kuo, TY Chen, HY Chia, JH Juang |
Scientific Reports | 2018 |
BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells
ME Oskarsson, E Hermansson, Y Wang, N Welsh, J Presto, J Johansson, GT Westermark |
Proceedings of the National Academy of Sciences | 2018 |
TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes
C Liu, W QiNan, L XiaoTian, Y MengLiu, G XiaGuang, L WeiLing, L ZiWen, Z Ling, Y GangYi, C Bing |
Journal of Diabetes Research | 2018 |
Role of Protein Phosphatase 1 and Inhibitor of Protein Phosphatase 1 in Nitric Oxide–Dependent Inhibition of the DNA Damage Response in Pancreatic β-Cells
BJ Oleson, A Naatz, SC Proudfoot, CT Yeo, JA Corbett |
Diabetes | 2018 |
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa
S Demine, A Balhuizen, V Debaille, L Joosten, M Fereau, S Chilla, I Millard, R Scharfmann, D Egrise, S Goldman, P Marchetti, M Gotthardt, S Laurent, C Burtea, D Eizirik |
Molecules (Basel, Switzerland) | 2018 |
MANF protects human pancreatic beta cells against stress-induced cell death
E Hakonen, V Chandra, CL Fogarty, NY Yu, J Ustinov, S Katayama, E Galli, T Danilova, P Lindholm, A Vartiainen, E Einarsdottir, K Krjutškov, J Kere, M Saarma, M Lindahl, T Otonkoski |
Diabetologia | 2018 |
Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism
X Jian, G Felsenfeld |
Proceedings of the National Academy of Sciences | 2018 |
Modeling human pancreatic beta cell dedifferentiation
M Diedisheim, M Oshima, O Albagli, CW Huldt, I Ahlstedt, M Clausen, S Menon, A Aivazidis, AC Andreasson, WG Haynes, P Marchetti, L Marselli, M Armanet, F Chimienti, R Scharfmann |
Molecular Metabolism | 2018 |
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci
M Thurner, M van de Bunt, JM Torres, A Mahajan, V Nylander, AJ Bennett, KJ Gaulton, A Barrett, C Burrows, CG Bell, R Lowe, S Beck, VK Rakyan, AL Gloyn, MI McCarthy |
eLife | 2018 |
Feeder-cell-independent culture of the pig embryonic stem cell-derived exocrine pancreatic cell line, PICM-31
NC Talbot, AE Shannon, CE Phillips, WM Garrett |
In vitro cellular & developmental biology. Animal | 2018 |
Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells
J Taneera, RB Prasad, S Dhaiban, AK Mohammed, L Haataja, P Arvan, M Hamad, L Groop, CB Wollheim |
Molecular and Cellular Endocrinology | 2018 |
Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
E Ifie, MA Russell, S Dhayal, P Leete, G Sebastiani, L Nigi, F Dotta, V Marjomäki, DL Eizirik, NG Morgan, SJ Richardson |
Diabetologia | 2018 |
Targeting GLP-1 receptor trafficking to improve agonist efficacy
B Jones, T Buenaventura, N Kanda, P Chabosseau, BM Owen, R Scott, R Goldin, N Angkathunyakul, IR Corrêa, D Bosco, PR Johnson, L Piemonti, P Marchetti, AM Shapiro, BJ Cochran, AC Hanyaloglu, A Inoue, T Tan, GA Rutter, A Tomas, SR Bloom |
Nature Communications | 2018 |
The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates
VG Tsonkova, FW Sand, XA Wolf, LG Grunnet, AK Ringgaard, C Ingvorsen, L Winkel, M Kalisz, K Dalgaard, C Bruun, JJ Fels, C Helgstrand, S Hastrup, FK Öberg, E Vernet, MP Sandrini, AC Shaw, C Jessen, M Grønborg, J Hald, H Willenbrock, D Madsen, R Wernersson, L Hansson, JN Jensen, A Plesner, T Alanentalo, MB Petersen, A Grapin-Botton, C Honoré, J Ahnfelt-Rønne, J Hecksher-Sørensen, P Ravassard, OD Madsen, C Rescan, T Frogne |
Molecular Metabolism | 2018 |
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
ML Colli, JL Hill, L Marroquí, J Chaffey, RS Santos, P Leete, AC de Brachène, FM Paula, AO de Beeck, A Castela, L Marselli, L Krogvold, K Dahl-Jorgensen, P Marchetti, NG Morgan, SJ Richardson, DL Eizirik |
EBioMedicine | 2018 |
Differentiation of Sendai virus-reprogrammed iPSC into β cells, compared with human pancreatic islets and immortalized β cell line
S Pellegrini, F Manenti, R Chimienti, R Nano, L Ottoboni, F Ruffini, G Martino, P Ravassard, L Piemonti, V Sordi |
Cell Transplantation | 2018 |
The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
X Wang, A Elksnis, P Wikström, E Walum, N Welsh, PO Carlsson, HH Schmidt |
PloS one | 2018 |
Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion
M Casimir, G Chaffard, P Maechler |
Pflügers Archiv - European Journal of Physiology | 2018 |
The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
KA Leslie, MA Russell, K Taniguchi, SJ Richardson, NG Morgan |
Diabetologia | 2018 |
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8
C Merriman, H Li, H Li, D Fu |
The Journal of biological chemistry | 2018 |
A neural network based model effectively predicts enhancers from clinical ATAC-seq samples
A Thibodeau, A Uyar, S Khetan, ML Stitzel, D Ucar |
Scientific Reports | 2018 |
Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
B Font-Cunill, L Arnes, J Ferrer, L Sussel, A Beucher |
Frontiers in Genetics | 2018 |
Bioluminescent reporter assay for monitoring ER stress in human beta cells
MJ Kracht, EJ de Koning, RC Hoeben, BO Roep, A Zaldumbide |
Scientific Reports | 2018 |
Modelling the endocrine pancreas in health and disease
M Bakhti, A Böttcher, H Lickert |
Nature Reviews Endocrinology | 2018 |
The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass
M Jahan, P Johnström, RK Selvaraju, M Svedberg, MS Winzell, J Bernström, L Kingston, M Schou, Z Jia, S Skrtic, L Johansson, O Korsgren, L Farde, C Halldin, O Eriksson |
EJNMMI Research | 2018 |
DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway
RS Santos, L Marroqui, T Velayos, A Olazagoitia-Garmendia, A Jauregi-Miguel, A Castellanos-Rubio, DL Eizirik, L Castaño, I Santin |
Diabetologia | 2018 |
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
T Zhou, TW Kim, CN Chong, L Tan, S Amin, ZS Badieyan, S Mukherjee, Z Ghazizadeh, H Zeng, M Guo, M Crespo, T Zhang, R Kenyon, CL Robinson, E Apostolou, H Wang, JZ Xiang, T Evans, L Studer, S Chen |
Nature Communications | 2018 |
BiFET: sequencing Bi as-free transcription factor F ootprint E nrichment T est
A Youn, EJ Marquez, N Lawlor, ML Stitzel, D Ucar |
Nucleic Acids Research | 2018 |
[Research progress on the donor cell sources of pancreatic islet transplantation for treatment of diabetes mellitus]
Haitao Zhu, Xiaoge Zhang, Yayi He, Liang Yu, Yi Lü, Kaili Pan, Bo Wang, Guoqiang Chen |
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | 2018 |
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
AS Axelsson, T Mahdi, HA Nenonen, T Singh, S Hänzelmann, A Wendt, A Bagge, TM Reinbothe, J Millstein, X Yang, B Zhang, EG Gusmao, L Shu, M Szabat, Y Tang, J Wang, S Salö, L Eliasson, I Artner, M Fex, JD Johnson, CB Wollheim, JM Derry, B Mecham, P Spégel, H Mulder, IG Costa, E Zhang, AH Rosengren |
Nature Communications | 2017 |
Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion
FK Ndiaye, A Ortalli, M Canouil, M Huyvaert, C Salazar-Cardozo, C Lecoeur, M Verbanck, V Pawlowski, R Boutry, E Durand, I Rabearivelo, O Sand, L Marselli, J Kerr-Conte, V Chandra, R Scharfmann, O Poulain-Godefroy, P Marchetti, F Pattou, A Abderrahmani, P Froguel, A Bonnefond |
Molecular Metabolism | 2017 |
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
E Dror, E Dalmas, DT Meier, S Wueest, J Thévenet, C Thienel, K Timper, TM Nordmann, S Traub, F Schulze, F Item, D Vallois, F Pattou, J Kerr-Conte, V Lavallard, T Berney, B Thorens, D Konrad, M Böni-Schnetzler, MY Donath |
Nature Immunology | 2017 |
Nutrient regulation of β-cell function: what do islet cell/animal studies tell us?
R Carlessi, KN Keane, C Mamotte, P Newsholme |
European Journal of Clinical Nutrition | 2017 |
Optogenetic regulation of insulin secretion in pancreatic β-cells
F Zhang, ES Tzanakakis |
Scientific Reports | 2017 |
Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts
N Lawlor, A Youn, R Kursawe, D Ucar, ML Stitzel |
Scientific Reports | 2017 |
Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress
A Lombardi, Y Tomer |
Journal of Autoimmunity | 2017 |
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
C Cruciani-Guglielmacci, L Bellini, J Denom, M Oshima, N Fernandez, P Normandie-Levi, XP Berney, N Kassis, C Rouch, J Dairou, T Gorman, DM Smith, A Marley, R Liechti, D Kuznetsov, L Wigger, F Burdet, AL Lefèvre, I Wehrle, I Uphues, T Hildebrandt, W Rust, C Bernard, A Ktorza, GA Rutter, R Scharfmann, I Xenarios, HL Stunff, B Thorens, C Magnan, M Ibberson |
Molecular Metabolism | 2017 |
Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
L Marroqui, RS Santos, AO de beeck, AC de Brachène, L Marselli, P Marchetti, DL Eizirik |
Diabetologia | 2017 |
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
I Akerman, Z Tu, A Beucher, DM Rolando, C Sauty-Colace, M Benazra, N Nakic, J Yang, H Wang, L Pasquali, I Moran, J Garcia-Hurtado, N Castro, R Gonzalez-Franco, AF Stewart, C Bonner, L Piemonti, T Berney, L Groop, J Kerr-Conte, F Pattou, C Argmann, E Schadt, P Ravassard, J Ferrer |
Cell Metabolism | 2017 |
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice
GR Carrat, M Hu, MS Nguyen-Tu, P Chabosseau, KJ Gaulton, M de Bunt, A Siddiq, M Falchi, M Thurner, M Canouil, F Pattou, I Leclerc, TJ Pullen, MC Cane, P Prabhala, W Greenwald, A Schulte, P Marchetti, M Ibberson, PE MacDonald, JE Fox, AL Gloyn, P Froguel, M Solimena, MI McCarthy, GA Rutter |
The American Journal of Human Genetics | 2017 |
EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium
C Krizhanovskii, H Kristinsson, A Elksnis, X Wang, H Gavali, P Bergsten, R Scharfmann, N Welsh |
Islets | 2017 |
β-Cell Replacement Strategies: The Increasing Need for a “β-Cell Dogma”
A Vieira, N Druelle, F Avolio, T Napolitano, S Navarro-Sanz, S Silvano, P Collombat |
Frontiers in Genetics | 2017 |
Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion
H Kristinsson, E Sargsyan, H Manell, DM Smith, SO Göpel, P Bergsten |
Scientific Reports | 2017 |
Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
J Juan-Mateu, TH Rech, O Villate, E Lizarraga-Mollinedo, A Wendt, JV Turatsinze, LA Brondani, TR Nardelli, TC Nogueira, JL Esguerra, MI Alvelos, P Marchetti, L Eliasson, DL Eizirik |
The Journal of biological chemistry | 2017 |
Confluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines
JK Ofori, HA Malm, IG Mollet, L Eliasson, JL Esguerra |
PeerJ | 2017 |
Addition of exogenous sodium palmitate increases the IAPP/insulin mRNA ratio via GPR40 in human EndoC-βH1 cells
C Krizhanovskii, RG Fred, ME Oskarsson, GT Westermark, N Welsh |
Upsala Journal of Medical Sciences | 2017 |
Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes
JO Nyalwidhe, GR Gallagher, LM Glenn, MA Morris, P Vangala, A Jurczyk, R Bortell, DM Harlan, JP Wang, JL Nadler |
Journal of the Endocrine Society | 2017 |
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
DA Cunha, M Cito, FA Grieco, C Cosentino, T Danilova, L Ladrière, M Lindahl, A Domanskyi, M Bugliani, P Marchetti, DL Eizirik, M Cnop |
The Journal of biological chemistry | 2017 |
Regenerative medicine and cell-based approaches to restore pancreatic function
C Ellis, A Ramzy, TJ Kieffer |
Nature Reviews Gastroenterology & Hepatology | 2017 |
Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions
A Oishi, A Karamitri, R Gerbier, O Lahuna, R Ahmad, R Jockers |
Scientific Reports | 2017 |
Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
RS Santos, L Marroqui, FA Grieco, L Marselli, M Suleiman, SR Henz, P Marchetti, R Wernersson, DL Eizirik |
Endocrinology | 2017 |
miR-204 is associated with an endocrine phenotype in human pancreatic islets but does not regulate the insulin mRNA through MAFA
I Marzinotto, S Pellegrini, C Brigatti, R Nano, R Melzi, A Mercalli, D Liberati, V Sordi, M Ferrari, M Falconi, C Doglioni, P Ravassard, L Piemonti, V Lampasona |
Scientific Reports | 2017 |
A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
A Balhuizen, S Massa, I Mathijs, JV Turatsinze, JD Vos, S Demine, C Xavier, O Villate, I Millard, D Egrise, C Capito, R Scharfmann, PI Veld, P Marchetti, S Muyldermans, S Goldman, T Lahoutte, L Bouwens, DL Eizirik, N Devoogdt |
Scientific Reports | 2017 |
MiR‐335 overexpression impairs insulin secretion through defective priming of insulin vesicles
VA Salunkhe, JK Ofori, NR Gandasi, SA Salö, S Hansson, ME Andersson, A Wendt, S Barg, JL Esguerra, L Eliasson |
Physiological Reports | 2017 |
Dynamics of Insulin Secretion from EndoC- β H1 β -Cell Pseudoislets in Response to Glucose and Other Nutrient and Nonnutrient Secretagogues
H Teraoku, S Lenzen |
Journal of Diabetes Research | 2017 |
SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival
J Juan-Mateu, MI Alvelos, JV Turatsinze, O Villate, E Lizarraga-Mollinedo, FA Grieco, L Marroquí, M Bugliani, P Marchetti, DL Eizirik |
Diabetes | 2017 |
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
M Solimena, AM Schulte, L Marselli, F Ehehalt, D Richter, M Kleeberg, H Mziaut, KP Knoch, J Parnis, M Bugliani, A Siddiq, A Jörns, F Burdet, R Liechti, M Suleiman, D Margerie, F Syed, M Distler, R Grützmann, E Petretto, A Moreno-Moral, C Wegbrod, A Sönmez, K Pfriem, A Friedrich, J Meinel, CB Wollheim, GB Baretton, R Scharfmann, E Nogoceke, E Bonifacio, D Sturm, B Meyer-Puttlitz, U Boggi, HD Saeger, F Filipponi, M Lesche, P Meda, A Dahl, L Wigger, I Xenarios, M Falchi, B Thorens, J Weitz, K Bokvist, S Lenzen, GA Rutter, P Froguel, M von Bülow, M Ibberson, P Marchetti |
Diabetologia | 2017 |
Xenotropic retrovirus Bxv1 in human pancreatic β cell lines
Jeannette Kirkegaard, Philippe Ravassard, Signe Ingvarsen, Marc Diedisheim, Emilie Bricout-Neveu, Mads Grønborg, Thomas Frogne, Raphaël Scharfmann, Ole Madsen, Claude Rescan, Olivier Albagli-Curiel |
Journal of Clinical Investigation | 2016 |
Stress-Impaired Transcription Factor Expression and Insulin Secretion in Human Islets
Chunhua Dai, Nora Kayton, Alena Shostak, Gregory Poffenberger, Holly Ann Cyphert, Radhika Aramandla, Courtney Thompson, Ioannis Papagiannis, Christopher Emfinger, Masakazu Shiota, John Stafford, Dale Greiner, Pedro Luis Herrera, Leonard Shultz, Roland Stein, Alvin Powers |
Journal of Clinical Investigation | 2016 |
Research Resource: Genetic Labeling of Human Islet Alpha Cells
PT Pauerstein, KM Park, HS Peiris, J Wang, SK Kim |
Molecular Endocrinology | 2016 |
Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines
E Gurgul-Convey, I Mehmeti, T Plötz, A Jörns, S Lenzen |
Diabetologia | 2016 |
Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice
ZB Mehta, N Fine, TJ Pullen, MC Cane, M Hu, P Chabosseau, G Meur, A Velayos-Baeza, AP Monaco, L Marselli, P Marchetti, GA Rutter |
American journal of physiology. Endocrinology and metabolism | 2016 |
Aggregation of Engineered Human β-Cells into Pseudoislets: Insulin Secretion and Gene Expression Profile in Normoxic and Hypoxic Milieu
MJ Lecomte, S Pechberty, C Machado, SD Barroca, P Ravassard, R Scharfmann, P Czernichow, B Duvillié |
Cell medicine | 2016 |
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology
NL Beer, AL Gloyn |
F1000Research | 2016 |
Identification of proliferative and mature β-cells in the islets of Langerhans
E Bader, A Migliorini, M Gegg, N Moruzzi, J Gerdes, SS Roscioni, M Bakhti, E Brandl, M Irmler, J Beckers, M Aichler, A Feuchtinger, C Leitzinger, H Zischka, R Wang-Sattler, M Jastroch, M Tschöp, F Machicao, H Staiger, HU Häring, H Chmelova, JA Chouinard, N Oskolkov, O Korsgren, S Speier, H Lickert |
Nature | 2016 |
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
F Brozzi, DL Eizirik |
Upsala Journal of Medical Sciences | 2016 |
Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells
F Brozzi, S Gerlo, FA Grieco, M Juusola, A Balhuizen, S Lievens, C Gysemans, M Bugliani, C Mathieu, P Marchetti, J Tavernier, DL Eizirik |
The Journal of biological chemistry | 2016 |
MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes
E Ganic, T Singh, C Luan, J Fadista, JK Johansson, HA Cyphert, H Bennet, P Storm, G Prost, H Ahlenius, E Renström, R Stein, L Groop, M Fex, I Artner |
Cell Reports | 2016 |
β-Cell glutamate signaling: Its role in incretin-induced insulin secretion
N Yokoi, G Gheni, H Takahashi, S Seino |
Journal of Diabetes Investigation | 2016 |
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
HE Arda, L Li, J Tsai, EA Torre, Y Rosli, H Peiris, RC Spitale, C Dai, X Gu, K Qu, P Wang, J Wang, M Grompe, R Scharfmann, MS Snyder, R Bottino, AC Powers, HY Chang, SK Kim |
Cell Metabolism | 2016 |
The Importance of Context: Uncovering Species- and Tissue-Specific Effects of Genetic Risk Variants for Type 2 Diabetes
SK Thomsen, MI McCarthy, AL Gloyn |
Frontiers in Endocrinology | 2016 |
PTB and TIAR binding to insulin mRNA 3′- and 5′UTRs; implications for insulin biosynthesis and messenger stability
RG Fred, S Mehrabi, CM Adams, N Welsh |
Heliyon | 2016 |
A Protocol to Enhance INS1E and MIN6 Functionality—The Use of Theophylline
MG Nibbelink, G Marchioli, L Moroni, M Karperien, AV Apeldoorn |
International journal of molecular sciences | 2016 |
Nitric Oxide Suppresses β-Cell Apoptosis by Inhibiting the DNA Damage Response
BJ Oleson, KA Broniowska, A Naatz, N Hogg, VL Tarakanova, JA Corbett |
Molecular and cellular biology | 2016 |
Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells
V Chandra, A Karamitri, P Richards, F Cormier, C Ramond, R Jockers, M Armanet, O Albagli-Curiel, R Scharfmann |
Scientific Reports | 2016 |
Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes
JA Olsen, LA Kenna, MG Spelios, MJ Hessner, EM Akirav, R Kulkarni |
PloS one | 2016 |
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants
SK Thomsen, A Ceroni, M de Bunt, C Burrows, A Barrett, R Scharfmann, D Ebner, MI McCarthy, AL Gloyn |
Diabetes | 2016 |
Immunogenicity of human embryonic stem cell-derived beta cells
CR van der Torren, A Zaldumbide, G Duinkerken, SH Brand-Schaaf, M Peakman, G Stangé, L Martinson, E Kroon, EP Brandon, D Pipeleers, BO Roep |
Diabetologia | 2016 |
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
FA Grieco, G Sebastiani, J Juan-Mateu, O Villate, L Marroqui, L Ladrière, K Tugay, R Regazzi, M Bugliani, P Marchetti, F Dotta, DL Eizirik |
Diabetes | 2016 |
Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice
AD Green, S Vasu, NH McClenaghan, PR Flatt |
World journal of diabetes | 2016 |
DNA methylation directs functional maturation of pancreatic beta cells
Sangeeta Dhawan, Shuen-ing Tschen, Chun Zeng, Tingxia Guo, Matthias Hebrok, Aleksey Matveyenko, Anil Bhushan |
Journal of Clinical Investigation | 2015 |
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
KJ Gaulton, T Ferreira, Y Lee, A Raimondo, R Mägi, ME Reschen, A Mahajan, A Locke, NW Rayner, N Robertson, RA Scott, I Prokopenko, LJ Scott, T Green, T Sparso, D Thuillier, L Yengo, H Grallert, S Wahl, M Frånberg, RJ Strawbridge, H Kestler, H Chheda, L Eisele, S Gustafsson, V Steinthorsdottir, G Thorleifsson, L Qi, LC Karssen, EM van Leeuwen, SM Willems, M Li, H Chen, C Fuchsberger, P Kwan, C Ma, M Linderman, Y Lu, SK Thomsen, JK Rundle, NL Beer, M de Bunt, A Chalisey, HM Kang, BF Voight, GR Abecasis, P Almgren, D Baldassarre, B Balkau, R Benediktsson, M Blüher, H Boeing, LL Bonnycastle, EP Bottinger, NP Burtt, J Carey, G Charpentier, PS Chines, MC Cornelis, DJ Couper, AT Crenshaw, RM van Dam, AS Doney, M Dorkhan, S Edkins, JG Eriksson, T Esko, E Eury, J Fadista, J Flannick, P Fontanillas, C Fox, PW Franks, K Gertow, C Gieger, B Gigante, O Gottesman, GB Grant, N Grarup, CJ Groves, M Hassinen, CT Have, C Herder, OL Holmen, AB Hreidarsson, SE Humphries, DJ Hunter, AU Jackson, A Jonsson, ME Jørgensen, T Jørgensen, WH Kao, ND Kerrison, L Kinnunen, N Klopp, A Kong, P Kovacs, P Kraft, J Kravic, C Langford, K Leander, L Liang, P Lichtner, CM Lindgren, E Lindholm, A Linneberg, CT Liu, S Lobbens, J Luan, V Lyssenko, S Männistö, O McLeod, J Meyer, E Mihailov, G Mirza, TW Mühleisen, M Müller-Nurasyid, C Navarro, MM Nöthen, NN Oskolkov, KR Owen, D Palli, S Pechlivanis, L Peltonen, JR Perry, CG Platou, M Roden, D Ruderfer, D Rybin, YT van der Schouw, B Sennblad, G Sigurðsson, A Stančáková, G Steinbach, P Storm, K Strauch, HM Stringham, Q Sun, B Thorand, E Tikkanen, A Tonjes, J Trakalo, E Tremoli, T Tuomi, R Wennauer, S Wiltshire, AR Wood, E Zeggini, I Dunham, E Birney, L Pasquali, J Ferrer, RJ Loos, J Dupuis, JC Florez, E Boerwinkle, JS Pankow, C Duijn, E Sijbrands, JB Meigs, FB Hu, U Thorsteinsdottir, K Stefansson, TA Lakka, R Rauramaa, M Stumvoll, NL Pedersen, L Lind, SM Keinanen-Kiukaanniemi, E Korpi-Hyövälti, TE Saaristo, J Saltevo, J Kuusisto, M Laakso, A Metspalu, R Erbel, KH Jöcke, S Moebus, S Ripatti, V Salomaa, E Ingelsson, BO Boehm, RN Bergman, FS Collins, KL Mohlke, H Koistinen, J Tuomilehto, K Hveem, I Njølstad, P Deloukas, PJ Donnelly, TM Frayling, AT Hattersley, U Faire, A Hamsten, T Illig, A Peters, S Cauchi, R Sladek, P Froguel, T Hansen, O Pedersen, AD Morris, CN Palmer, S Kathiresan, O Melander, PM Nilsson, LC Groop, I Barroso, C Langenberg, NJ Wareham, CA O'Callaghan, AL Gloyn, D Altshuler, M Boehnke, TM Teslovich, MI McCarthy, AP Morris |
Nature Genetics | 2015 |
Diabetes mellitus—advances and challenges in human β-cell proliferation
P Wang, NM Fiaschi-Taesch, RC Vasavada, DK Scott, A García-Ocaña, AF Stewart |
Nature Reviews Endocrinology | 2015 |
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
C Tang, K Ahmed, A Gille, S Lu, HJ Gröne, S Tunaru, S Offermanns |
Nature Medicine | 2015 |
Dynamic Recruitment of Functionally Distinct Swi/Snf Chromatin Remodeling Complexes Modulates Pdx1 Activity in Islet β Cells
B McKenna, M Guo, A Reynolds, M Hara, R Stein |
Cell Reports | 2015 |
Human islet distribution programme for basic research: activity over the last 5 years
R Nano, D Bosco, JA Kerr-Conte, M Karlsson, S Charvier, R Melzi, R Ezzouaoui, A Mercalli, A Hwa, F Pattou, O Korsgren, T Berney, L Piemonti |
Diabetologia | 2015 |
Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets
J Hilderink, S Spijker, F Carlotti, L Lange, M Engelse, C Blitterswijk, E Koning, M Karperien, A Apeldoorn |
Journal of Cellular and Molecular Medicine | 2015 |
Co-Culture of α TC-6 Cells and β TC-1 Cells: Morphology and Function
SM Kim, EJ Lee, HS Jung, N Han, YJ Kim, TK Kim, TN Kim, MJ Kwon, SH Lee, JH Park, BD Rhee, MK Kim |
Endocrinology and Metabolism | 2015 |
Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line
LE Andersson, B Valtat, A Bagge, VV Sharoyko, DG Nicholls, P Ravassard, R Scharfmann, P Spégel, H Mulder, B Wagner |
PloS one | 2015 |
Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
F Brozzi, TR Nardelli, M Lopes, I Millard, J Barthson, M Igoillo-Esteve, FA Grieco, O Villate, JM Oliveira, M Casimir, M Bugliani, F Engin, GS Hotamisligil, P Marchetti, DL Eizirik |
Diabetologia | 2015 |
Analysis artefacts of the INS-IGF2 fusion transcript
R Wernersson, T Frogne, C Rescan, L Hansson, C Bruun, M Grønborg, JN Jensen, OD Madsen |
BMC Molecular Biology | 2015 |
Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines
BJ Oleson, JA McGraw, KA Broniowska, M Annamalai, J Chen, JR Bushkofsky, DB Davis, JA Corbett, CE Mathews |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2015 |
A human beta cell line with drug inducible excision of immortalizing transgenes
M Benazra, MJ Lecomte, C Colace, A Müller, C Machado, S Pechberty, E Bricout-Neveu, M Grenier-Godard, M Solimena, R Scharfmann, P Czernichow, P Ravassard |
Molecular Metabolism | 2015 |
MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function
DW Scoville, HA Cyphert, L Liao, J Xu, A Reynolds, S Guo, R Stein |
Diabetes | 2015 |
Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy
CR van der Torren, A Zaldumbide, DL Roelen, G Duinkerken, SH Brand-Schaaf, M Peakman, P Czernichow, P Ravassard, R Scharfmann, BO Roep |
Diabetologia | 2015 |
Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans
A Pal, TP Potjer, SK Thomsen, HJ Ng, A Barrett, R Scharfmann, TJ James, DT Bishop, F Karpe, IF Godsland, HF Vasen, J Newton-Bishop, H Pijl, MI McCarthy, AL Gloyn |
Diabetes | 2015 |
Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells
L Paul, EM Walker, Y Drosos, HA Cyphert, G Neale, R Stein, J South, G Grosveld, PL Herrera, B Sosa-Pineda |
Diabetes | 2015 |
The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro
K Meyerovich, M Fukaya, LF Terra, F Ortis, DL Eizirik, AK Cardozo |
Diabetologia | 2015 |
When is it MODY? Challenges in the Interpretation of Sequence Variants in MODY Genes
S Althari, AL Gloyn |
The review of diabetic studies : RDS | 2015 |
A conditionally immortalized human pancreatic beta cell line
Raphaël Scharfmann, Severine Pechberty, Yasmine Hazhouz, Manon von Bülow, Emilie Bricout-Neveu, Maud Grenier-Godard, Fanny Guez, Latif Rachdi, Mathias Lohmann, Paul Czernichow, Philippe Ravassard |
Journal of Clinical Investigation | 2014 |
A New Method for Generating Insulin-secreting Cells from Human Pancreatic Epithelial Cells after Islet Isolation Transformed by NeuroD1
M Shimoda, S Chen, H Noguchi, M Takita, K Sugimoto , T Itoh, D Chujo, S Iwahashi, B Naziruddin, MF Levy, S Matsumoto , P Grayburn |
Human Gene Therapy Methods | 2014 |
Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes
M Figliuzzi, B Bonandrini, S Silvani, A Remuzzi |
World journal of stem cells | 2014 |
Targeting the pancreatic β-cell to treat diabetes
A Vetere, A Choudhary, SM Burns, BK Wagner |
Nature Reviews Drug Discovery | 2014 |
Adult tissue sources for new β cells
RJ Nichols, C New, JP Annes |
Translational Research | 2014 |
The Missing lnc(RNA) between the pancreatic β-cell and diabetes
V Kameswaran, KH Kaestner |
Frontiers in Genetics | 2014 |
In search of a surrogate: engineering human beta cell lines for therapy
BN Newby, N Terada, CE Mathews |
Trends in Endocrinology & Metabolism | 2014 |
Revealing transcription factors during human pancreatic β cell development
E Conrad, R Stein, CS Hunter |
Trends in Endocrinology & Metabolism | 2014 |
The pancreatic β cell: recent insights from human genetics
SK Thomsen, AL Gloyn |
Trends in Endocrinology & Metabolism | 2014 |
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
L Pasquali, KJ Gaulton, SA Rodríguez-Seguí, L Mularoni, I Miguel-Escalada, İ Akerman, JJ Tena, I Morán, C Gómez-Marín, M de Bunt, J Ponsa-Cobas, N Castro, T Nammo, I Cebola, J García-Hurtado, MA Maestro, F Pattou, L Piemonti, T Berney, AL Gloyn, P Ravassard, JL Skarmeta, F Müller, MI McCarthy, J Ferrer |
Nature Genetics | 2014 |
Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans
JL Esguerra, L Eliasson |
Frontiers in Genetics | 2014 |
A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells
F Brozzi, S Gerlo, FA Grieco, TR Nardelli, S Lievens, C Gysemans, L Marselli, P Marchetti, C Mathieu, J Tavernier, DL Eizirik |
The Journal of biological chemistry | 2014 |
In Vitro Differentiation and Expansion of Human Pluripotent Stem Cell-Derived Pancreatic Progenitors
J Chmielowiec, M Borowiak |
The review of diabetic studies : RDS | 2014 |
Islet β cell mass in diabetes and how it relates to function, birth, and death
GC Weir, S Bonner-Weir |
Annals of the New York Academy of Sciences | 2013 |
Animal models of GWAS-identified type 2 diabetes genes
GS Xavier, EA Bellomo, JA McGinty, PM French, GA Rutter |
Journal of Diabetes Research | 2013 |
Bridging the Gap Between Genetic Associations and Molecular Mechanisms for Type 2 Diabetes
HJ Ng, AL Gloyn |
Current Diabetes Reports | 2013 |
Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl
D Mokhtari, A Al-Amin, K Turpaev, T Li, O Idevall-Hagren, J Li, A Wuttke, RG Fred, P Ravassard, R Scharfmann, A Tengholm, N Welsh |
Diabetologia | 2013 |
miR-25 and miR-92a regulate insulin I biosynthesis in rats
DS Karolina, S Sepramaniam, HZ Tan, A Armugam, K Jeyaseelan |
RNA biology | 2013 |
Public-private partnerships as driving forces in the quest for innovative medicines
M Goldman, C Compton, BB Mittleman |
Clinical and Translational Medicine | 2013 |
IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets
FA Grieco, F Moore, F Vigneron, I Santin, O Villate, L Marselli, D Rondas, H Korf, L Overbergh, F Dotta, P Marchetti, C Mathieu, DL Eizirik |
Diabetologia | 2013 |
Human fetal pancreatic islet-like structures as source material to treat type 1 diabetes
Y Ikeda, YC Kudva |
Stem Cell Research & Therapy | 2013 |
The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis
M de Bunt, KJ Gaulton, L Parts, I Moran, PR Johnson, CM Lindgren, J Ferrer, AL Gloyn, MI McCarthy |
PloS one | 2013 |
Concise review: in search of unlimited sources of functional human pancreatic beta cells
R Scharfmann, L Rachdi, P Ravassard |
Stem Cells Translational Medicine | 2012 |
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
I Morán, İ Akerman, M van de Bunt, R Xie, M Benazra, T Nammo, L Arnes, N Nakić, J García-Hurtado, S Rodríguez-Seguí, L Pasquali, C Sauty-Colace, A Beucher, R Scharfmann, J van Arensbergen, PR Johnson, A Berry, C Lee, T Harkins, V Gmyr, F Pattou, J Kerr-Conte, L Piemonti, T Berney, N Hanley, AL Gloyn, L Sussel, L Langman, KL Brayman, M Sander, MI McCarthy, P Ravassard, J Ferrer |
Cell Metabolism | 2012 |
Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines
YL Lightfoot, J Chen, CE Mathews |
European Journal of Clinical Investigation | 2012 |
Inherited -Cell Dysfunction in Lean Individuals With Type 2 Diabetes
AE Mathews, CE Mathews |
Diabetes | 2012 |
Public-private partnerships need honest brokering
M Goldman |
Nature Medicine | 2012 |
Finally! A human pancreatic beta cell line
Gordon C. Weir, Susan Bonner-Weir |
Journal of Clinical Investigation | 2011 |
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