Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Version history
  • Article usage
  • Citations to this article (0)

Advertisement

Corrigendum Free access | 10.1172/JCI57722

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

Françoise Leviel, Christian A. Hübner, Pascal Houillier, Luciana Morla, Soumaya El Moghrabi, Gaëlle Brideau, Hatim Hassan, Mark D. Parker, Ingo Kurth, Alexandra Kougioumtzes, Anne Sinning, Vladimir Pech, Kent A. Riemondy, R. Lance Miller, Edith Hummler,10 Gary E. Shull,11 Peter S. Aronson, Alain Doucet, Susan M. Wall, Régine Chambrey, and Dominique Eladari

Find articles by Leviel, F. in: JCI | PubMed | Google Scholar

Find articles by Hübner, C. in: JCI | PubMed | Google Scholar

Find articles by Houillier, P. in: JCI | PubMed | Google Scholar

Find articles by Morla, L. in: JCI | PubMed | Google Scholar

Find articles by El Moghrabi, S. in: JCI | PubMed | Google Scholar

Find articles by Brideau, G. in: JCI | PubMed | Google Scholar

Find articles by Hassan, H. in: JCI | PubMed | Google Scholar

Find articles by Parker, M. in: JCI | PubMed | Google Scholar

Find articles by Kurth, I. in: JCI | PubMed | Google Scholar

Find articles by Kougioumtzes, A. in: JCI | PubMed | Google Scholar

Find articles by Sinning, A. in: JCI | PubMed | Google Scholar

Find articles by Pech, V. in: JCI | PubMed | Google Scholar

Find articles by Riemondy, K. in: JCI | PubMed | Google Scholar

Find articles by Miller, R. in: JCI | PubMed | Google Scholar

Find articles by Hummler, E. in: JCI | PubMed | Google Scholar

Find articles by Shull, G. in: JCI | PubMed | Google Scholar

Find articles by Aronson, P. in: JCI | PubMed | Google Scholar

Find articles by Doucet, A. in: JCI | PubMed | Google Scholar

Find articles by Wall, S. in: JCI | PubMed | Google Scholar

Find articles by Chambrey, R. in: JCI | PubMed | Google Scholar

Find articles by Eladari, D. in: JCI | PubMed | Google Scholar

Published April 1, 2011 - More info

Published in Volume 121, Issue 4 on April 1, 2011
J Clin Invest. 2011;121(4):1668–1668. https://doi.org/10.1172/JCI57722.
© 2011 The American Society for Clinical Investigation
Published April 1, 2011 - Version history
View PDF

Related article:

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
Françoise Leviel, … , Régine Chambrey, Dominique Eladari
Françoise Leviel, … , Régine Chambrey, Dominique Eladari
Research Article Article has an altmetric score of 11

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

  • Text
  • PDF
Abstract

Regulation of sodium balance is a critical factor in the maintenance of euvolemia, and dysregulation of renal sodium excretion results in disorders of altered intravascular volume, such as hypertension. The amiloride-sensitive epithelial sodium channel (ENaC) is thought to be the only mechanism for sodium transport in the cortical collecting duct (CCD) of the kidney. However, it has been found that much of the sodium absorption in the CCD is actually amiloride insensitive and sensitive to thiazide diuretics, which also block the Na-Cl cotransporter (NCC) located in the distal convoluted tubule. In this study, we have demonstrated the presence of electroneutral, amiloride-resistant, thiazide-sensitive, transepithelial NaCl absorption in mouse CCDs, which persists even with genetic disruption of ENaC. Furthermore, hydrochlorothiazide (HCTZ) increased excretion of Na+ and Cl– in mice devoid of the thiazide target NCC, suggesting that an additional mechanism might account for this effect. Studies on isolated CCDs suggested that the parallel action of the Na+-driven Cl–/HCO3– exchanger (NDCBE/SLC4A8) and the Na+-independent Cl–/HCO3– exchanger (pendrin/SLC26A4) accounted for the electroneutral thiazide-sensitive sodium transport. Furthermore, genetic ablation of SLC4A8 abolished thiazide-sensitive NaCl transport in the CCD. These studies establish what we believe to be a novel role for NDCBE in mediating substantial Na+ reabsorption in the CCD and suggest a role for this transporter in the regulation of fluid homeostasis in mice.

Authors

Françoise Leviel, Christian A. Hübner, Pascal Houillier, Luciana Morla, Soumaya El Moghrabi, Gaëlle Brideau, Hassan Hatim, Mark D. Parker, Ingo Kurth, Alexandra Kougioumtzes, Anne Sinning, Vladimir Pech, Kent A. Riemondy, R. Lance Miller, Edith Hummler, Gary E. Shull, Peter S. Aronson, Alain Doucet, Susan M. Wall, Régine Chambrey, Dominique Eladari

×

Original citation: J. Clin. Invest. 2010;120(5):1627–1635. doi:10.1172/JCI40145.

Citation for this corrigendum: J. Clin. Invest. 2011;121(4):1668. doi:10.1172/JCI57722.

Hatim Hassan’s name was given incorrectly in the author list. The correct author list appears above.

The authors regret the error.

Version history
  • Version 1 (April 1, 2011): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article (0)

Go to

  • Top
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Blogged by 1
Posted by 5 X users
Highlighted by 1 platforms
Referenced by 1 Bluesky users
67 readers on Mendeley
See more details