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Usage Information

Genetic control of hepatitis A severity and susceptibility to allergy
Lucienne Chatenoud, Jean-François Bach
Lucienne Chatenoud, Jean-François Bach
Published February 21, 2011
Citation Information: J Clin Invest. 2011;121(3):848-850. https://doi.org/10.1172/JCI46418.
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Commentary

Genetic control of hepatitis A severity and susceptibility to allergy

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Abstract

Hepatitis A virus (HAV) usually results in asymptomatic infection or mild disease, but in a small subset of patients it can lead to severe disease and even liver failure. In this issue of the JCI, Kim et al. identify a polymorphism associated with this increased disease risk in the gene that encodes the HAV receptor — TIM1. Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals.

Authors

Lucienne Chatenoud, Jean-François Bach

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