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Lukas Baitsch, … , Nathalie Rufer, Daniel E. Speiser
Published May 9, 2011
Citation Information: J Clin Invest. 2011;121(6):2350-2360. https://doi.org/10.1172/JCI46102.
Citation Information: J Clin Invest. 2011;121(6):2350-2360. https://doi.org/10.1172/JCI46102.
Abstract
In chronic viral infections, CD8+ T cells become functionally deficient and display multiple molecular alterations. In contrast, only little is known of self- and tumor-specific CD8+ T cells from mice and humans. Here we determined molecular profiles of tumor-specific CD8+ T cells from melanoma patients. In peripheral blood from patients vaccinated with CpG and the melanoma antigen Melan-A/MART-1 peptide, we found functional effector T cell populations, with only small but nevertheless significant differences in T cells specific for persistent herpesviruses (EBV and CMV). In contrast, Melan-A/MART-1–specific T cells isolated from metastases from patients with melanoma expressed a large variety of genes associated with T cell exhaustion. The identified exhaustion profile revealed extended molecular alterations. Our data demonstrate a remarkable coexistence of effector cells in circulation and exhausted cells in the tumor environment. Functional T cell impairment is mediated by inhibitory receptors and further molecular pathways, which represent potential targets for cancer therapy.
Authors
Lukas Baitsch, Petra Baumgaertner, Estelle Devêvre, Sunil K. Raghav, Amandine Legat, Leticia Barba, Sébastien Wieckowski, Hanifa Bouzourene, Bart Deplancke, Pedro Romero, Nathalie Rufer, Daniel E. Speiser
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Citations to this article (509)
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Adoptive Cellular Therapy for Multiple Myeloma Using CAR- and TCR-Transgenic T Cells: Response and Resistance
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Cells | 2022 |
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hDirect-MAP: projection-free single-cell modeling of response to checkpoint immunotherapy
Y Lu, G Xue, N Zheng, K Han, W Yang, R Wang, L Wu, L Miller, T Pardee, P Triozzi, H Lo, K Watabe, S Wong, B Pasche, W Zhang, G Jin |
Briefings in Bioinformatics | 2022 |
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Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications
J Vuong, A Stein-Merlob, A Nayeri, T Sallam, T Neilan, E Yang |
Journal of the American College of Cardiology | 2022 |
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Immune Cells in Hyperprogressive Disease under Immune Checkpoint-Based Immunotherapy
Wei Z, Zhang Y |
Cells | 2022 |
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Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer.
Kamat K, Krishnan V, Dorigo O |
British Journal of Cancer | 2022 |
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Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
Kim AR, Choi SJ, Park J, Kwon M, Chowdhury T, Yu HJ, Kim S, Kang H, Kim KM, Park SH, Park CK, Shin EC |
OncoImmunology | 2022 |
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T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
Ravi VM, Neidert N, Will P, Joseph K, Maier JP, Kückelhaus J, Vollmer L, Goeldner JM, Behringer SP, Scherer F, Boerries M, Follo M, Weiss T, Delev D, Kernbach J, Franco P, Schallner N, Dierks C, Carro MS, Hofmann UG, Fung C, Sankowski R, Prinz M, Beck J, Salié H, Bengsch B, Schnell O, Heiland DH |
Nature Communications | 2022 |
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An activation to memory differentiation trajectory of tumor infiltrating lymphocytes informs metastatic melanoma outcomes
Jaiswal A, Verma A, Dannenfelser R, Melssen M, Tirosh I, Izar B, Kim TG, Nirschl CJ, Devi KS, Olson WC Jr, Slingluff CL Jr, Engelhard VH, Garraway L, Regev A, Minkis K, Yoon CH, Troyanskaya O, Elemento O, Suárez-Fariñas M, Anandasabapathy N |
Cancer Cell | 2022 |
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Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
Noyes D, Bag A, Oseni S, Semidey-Hurtado J, Cen L, Sarnaik AA, Sondak VK, Adeegbe D |
Journal for ImmunoTherapy of Cancer | 2022 |
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The Unfolded Protein Response at the Tumor-Immune Interface
Zanetti M, Xian S, Dosset M, Carter H |
Frontiers in immunology | 2022 |
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Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle-invasive bladder cancer
Xu Y, Zeng H, Jin K, Liu Z, Zhu Y, Xu L, Wang Z, Chang Y, Xu J |
Journal for ImmunoTherapy of Cancer | 2022 |
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Diffuse large B-cell lymphoma (DLBCL) is infiltrated with activated CD8+ T-cells despite immune checkpoint signaling
Greenbaum AM, Fromm JR, Gopal AK, Houghton AM |
Blood Research | 2022 |
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The CD226/TIGIT axis is involved in T cell hypo-responsiveness appearance in long-term kidney transplant recipients
Del Bello A, Gouin A, Chaubet C, Kamar N, Treiner E |
Scientific Reports | 2022 |
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Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1
Rossignol J, Belaid Z, Fouquet G, Guillem F, Rignault R, Milpied P, Renand A, Coman T, D\u2019Aveni M, Dussiot M, Colin E, Levy J, Carvalho C, Goudin N, Cagnard N, Côté F, Babdor J, Bhukhai K, Polivka L, Bigorgne AE, Halse H, Marabelle A, Mouraud S, Lepelletier Y, Maciel TT, Rubio MT, Heron D, Robert C, Girault I, Lebeherec D, Scoazec JY, Moura I, Condon L, Weimershaus M, Pages F, Davoust J, Gross D, Hermine O |
iScience | 2022 |
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Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancer
Rossetti R, Brand H, Lima SC, Furtado IP, Silveira RM, Fantacini DM, Covas DT, de Souza LE |
2022 | |
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Glucometabolic reprogramming: From trigger to therapeutic target in hepatocellular carcinoma
Xia H, Huang Z, Wang Z, Liu S, Zhao X, You J, Xu Y, Yam JW, Cui Y |
Frontiers in Oncology | 2022 |
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Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity.
Yan Y, Huang L, Liu Y, Yi M, Chu Q, Jiao D, Wu K |
Journal of Hematology & Oncology | 2022 |
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The promising immune checkpoint LAG-3 in cancer immunotherapy: from basic research to clinical application
Huo JL, Wang YT, Fu WJ, Lu N, Liu ZS |
Frontiers in immunology | 2022 |
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Superinduction of immunosuppressive glioblastoma extracellular vesicles by IFN-γ through PD-L1 and IDO1.
Jung MY, Aibaidula A, Brown DA, Himes BT, Cumba Garcia LM, Parney IF |
2022 | |
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Stem-like T cells and niches: Implications in human health and disease
Yi L, Yang L |
Frontiers in immunology | 2022 |
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Anti-Tumor Effect of Parasitic Protozoans.
Ding H, Wu S, Jin Z, Zheng B, Hu Y, He K, Lu S, Zhuo X |
2022 | |
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Differential expression of HAVCR2 gene in pan-cancer: A potential biomarker for survival and immunotherapy
Li H, Yang D, Hao M, Liu H |
Frontiers in Genetics | 2022 |
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Intratumoral Niches of B Cells and Follicular Helper T Cells, and the Absence of Regulatory T Cells, Associate with Longer Survival in Early-Stage Oral Tongue Cancer Patients.
Phanthunane C, Wijers R, De Herdt MJ, Koljenovicć S, Sleijfer S, Baatenburg de Jong RJ, Hardillo JAU, Debets R, Balcioglu HE |
Cancers | 2022 |
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LAG-3 as a Potent Target for Novel Anticancer Therapies of a Wide Range of Tumors.
Sauer N, Szlasa W, Jonderko L, Oślizło M, Kunachowicz D, Kulbacka J, Karłowicz-Bodalska K |
International journal of molecular sciences | 2022 |
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Transcriptome analysis of Homo sapiens and Mus musculus reveals mechanisms of CD8+ T cell exhaustion caused by different factors
Zhang L, Nishi H |
PloS one | 2022 |
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Coexpression of lymphocyte-activation gene 3 and programmed death ligand-1 in tumor infiltrating immune cells predicts worse outcome in renal cell carcinoma
Lee CH, Jung SJ, Seo WI, Chung JI, Lee DS, Jeong DH, Jeon Y, Choi I |
International journal of immunopathology and pharmacology | 2022 |
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Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
Nath PR, Pal-Nath D, Kaur S, Gangaplara A, Meyer TJ, Cam MC, Roberts DD |
OncoImmunology | 2022 |
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Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade.
Liu B, Zhang Y, Wang D, Hu X, Zhang Z |
2022 | |
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Neoantigens and their clinical applications in human gastrointestinal cancers.
Eshkiki ZS, Agah S, Tabaeian SP, Sedaghat M, Dana F, Talebi A, Akbari A |
World journal of surgical oncology | 2022 |
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Clinical implications of T cell exhaustion for cancer immunotherapy.
Chow A, Perica K, Klebanoff CA, Wolchok JD |
Nature reviews. Clinical oncology | 2022 |
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Dynamic analysis of immune status in patients with intracranial germ cell tumor and establishment of an immune risk prognostic model.
Wang H, Huang H, Lin X, Chi P, Chen H, Chen J, Mou Y, Chen Z, Yang Q, Guo C |
Frontiers in immunology | 2022 |
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors.
Natoli M, Hatje K, Gulati P, Junker F, Herzig P, Jiang Z, Davydov II, Germann M, Trüb M, Marbach D, Zwick A, Weber P, Seeber S, Wiese M, Lardinois D, Heinzelmann-Schwarz V, Rosenberg R, Tietze L, Mertz KD, Umaña P, Klein C, Codarri-Deak L, Kao H, Zippelius A |
Journal for ImmunoTherapy of Cancer | 2022 |
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Immunometabolism in the tumor microenvironment and its related research progress
Zhang Z, Hu Y, Chen Y, Chen Z, Zhu Y, Chen M, Xia J, Sun Y, Xu W |
Frontiers in Oncology | 2022 |
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Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer
Imamura K, Tomita Y, Sato R, Ikeda T, Iyama S, Jodai T, Takahashi M, Takaki A, Akaike K, Hamada S, Sakata S, Saruwatari K, Saeki S, Ikeda K, Suzuki M, Sakagami T |
International journal of molecular sciences | 2022 |
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The Emerging Role of NK Cells in Immune Checkpoint Blockade
Martinez-Perez A, Aguilar-Garcia C, Gonzalez S |
Cancers | 2022 |
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Atherosclerosis With Immune Checkpoint Inhibitor Therapy: Evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review.
Suero-Abreu GA, Zanni MV, Neilan TG |
2022 | |
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Mutant and non-mutant neoantigen-based cancer vaccines: recent advances and future promises
Ashi MO, Mami-Chouaib F, Corgnac S |
2022 | |
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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade
Palmer DC, Webber BR, Patel Y, Johnson MJ, Kariya CM, Lahr WS, Parkhurst MR, Gartner JJ, Prickett TD, Lowery FJ, Kishton RJ, Gurusamy D, Franco Z, Vodnala SK, Diers MD, Wolf NK, Slipek NJ, McKenna DH, Sumstad D, Viney L, Henley T, Bürckstümmer T, Baker O, Hu Y, Yan C, Meerzaman D, Padhan K, Lo W, Malekzadeh P, Jia L, Deniger DC, Patel SJ, Robbins PF, McIvor RS, Choudhry M, Rosenberg SA, Moriarity BS, Restifo NP |
2022 | |
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CD8+ T cells inhibit metastasis and CXCL4 regulates its function
R Joseph, R Soundararajan, S Vasaikar, F Yang, KL Allton, L Tian, P den Hollander, S Isgandarova, M Haemmerle, B Mino, T Zhou, C Shin, M Martinez-Paniagua, AA Sahin, J Rodriguez-Canales, J Gelovani, JT Chang, G Acharya, AK Sood, II Wistuba, DL Gibbons, LM Solis, MC Barton, N Varadarajan, JM Rosen, XH Zhang, SA Mani |
British Journal of Cancer | 2021 |
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NK and NKT cells have distinct properties and functions in cancer
X Liu, L Li, F Si, L Huang, Y Zhao, C Zhang, DF Hoft, G Peng |
Oncogene | 2021 |
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Targeting STAT3 Abrogates Tim-3 Upregulation of Adaptive Resistance to PD-1 Blockade on Regulatory T Cells of Melanoma
L Huang, Y Xu, J Fang, W Liu, J Chen, Z Liu, Q Xu |
Frontiers in immunology | 2021 |
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Improving CAR T-Cell Persistence
V Pietrobon, LA Todd, A Goswami, O Stefanson, Z Yang, F Marincola |
International journal of molecular sciences | 2021 |
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Biomechanics of T Cell Dysfunctions in Chronic Diseases
SD Gunasinghe, NG Peres, J Goyette, K Gaus |
Frontiers in immunology | 2021 |
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CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger |
Nature Reviews Immunology | 2021 |
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The Role of Programmed Death-1 in Type 1 Diabetes
CG Tucker, AJ Dwyer, BT Fife, T Martinov |
Current Diabetes Reports | 2021 |
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Redirecting host preexisting influenza A virus immunity for cancer immunotherapy
BK Chaganty, S Qiu, Y Lu, G Lopez-Berestein, B Ozpolat, Z Fan |
Cancer Immunology, Immunotherapy | 2021 |
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The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy
S Asiry, G Kim, PS Filippou, LR Sanchez, D Entenberg, DK Marks, MH Oktay, GS Karagiannis |
Frontiers in immunology | 2021 |
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Nature vs. Nurture: The Two Opposing Behaviors of Cytotoxic T Lymphocytes in the Tumor Microenvironment
N Capitani, L Patrussi, CT Baldari |
International journal of molecular sciences | 2021 |
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Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
JL Collier, SA Weiss, KE Pauken, DR Sen, AH Sharpe |
Nature Immunology | 2021 |
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PDL1‐positive exosomes suppress antitumor immunity by inducing tumor‐specific CD8 + T cell exhaustion during metastasis
J Chen, Y Song, F Miao, G Chen, Y Zhu, N Wu, L Pang, Z Chen, X Chen |
Cancer Science | 2021 |
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Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy
A Isser, NK Livingston, JP Schneck |
Biomaterials | 2021 |
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Post‐transcriptional control of T‐cell cytokine production: Implications for cancer therapy
JJ Heeren |
Immunology | 2021 |
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Nanoparticle-based approaches to target the lymphatic system for antitumor treatment
X Peng, J Wang, F Zhou, Q Liu, Z Zhang |
Cellular and Molecular Life Sciences | 2021 |
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Next-Generation Immunotherapy Approaches in Melanoma
T Buchanan, A Amouzegar, JJ Luke |
Current Oncology Reports | 2021 |
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Self-Replicating RNAs Drive Protective Anti-tumor T Cell Responses to Neoantigen Vaccine Targets in a Combinatorial Approach
CJ Maine, G Richard, DS Spasova, SJ Miyake-Stoner, J Sparks, L Moise, RP Sullivan, O Garijo, M Choz, JM Crouse, A Aguilar, MD Olesiuk, K Lyons, K Salvador, M Blomgren, JL DeHart, KI Kamrud, G Berdugo, AS Groot, NS Wang, P Aliahmad |
Molecular Therapy | 2021 |
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Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes
ZR Huinen, EJ Huijbers, JR van Beijnum, P Nowak-Sliwinska, AW Griffioen |
Nature Reviews Clinical Oncology | 2021 |
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Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy
K Peltonen, S Feola, HM Umer, J Chiaro, G Mermelekas, E Ylösmäki, S Pesonen, RM Branca, J Lehtiö, V Cerullo |
Cancers | 2021 |
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Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy
I Lodewijk, SP Nunes, R Henrique, C Jerónimo, M Dueñas, JM Paramio |
Clinical Epigenetics | 2021 |
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Complement‐activated human endothelial cells stimulate increased polyfunctionality in alloreactive T cells
CB Xie, J Zhou, S Mackay, JS Pober |
American Journal of Transplantation | 2021 |
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Harnessing the IL-21-BATF Pathway in the CD8+ T Cell Anti-Tumor Response
P Topchyan, G Xin, Y Chen, S Zheng, R Burns, J Shen, MY Kasmani, M Kudek, N Yang, W Cui |
Cancers | 2021 |
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LAG-3-Expressing Tumor-Infiltrating T Cells Are Associated with Reduced Disease-Free Survival in Pancreatic Cancer
L Seifert, I Plesca, L Müller, U Sommer, M Heiduk, J von Renesse, D Digomann, J Glück, A Klimova, J Weitz, M Schmitz, AM Seifert |
Cancers | 2021 |
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The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer
A Beumer-Chuwonpad, RL Taggenbrock, TA Ngo, K van Gisbergen |
Cells | 2021 |
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Immunotherapy in older patients with cancer
C Granier, A Gey, S Roncelin, L Weiss, E Paillaud, E Tartour |
Biomedical journal | 2021 |
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IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
Y Liu, N Zhou, L Zhou, J Wang, Y Zhou, T Zhang, Y Fang, J Deng, Y Gao, X Liang, J Lv, Z Wang, J Xie, Y Xue, H Zhang, J Ma, K Tang, Y Fang, F Cheng, C Zhang, B Dong, Y Zhao, P Yuan, Q Gao, H Zhang, FX Qin, B Huang |
Nature Immunology | 2021 |
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Schrödinger’s T Cells: Molecular Insights Into Stemness and Exhaustion
NM Gonzalez, D Zou, A Gu, W Chen |
Frontiers in immunology | 2021 |
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Manganese Ferrite Nanoparticles Enhance the Sensitivity of Hepa1-6 Hepatocellular Carcinoma to Radiation by Remodeling Tumor Microenvironments
SW Shin, K Yang, M Lee, J Moon, A Son, Y Kim, S Choi, D Kim, C Choi, N Lee, HC Park |
International journal of molecular sciences | 2021 |
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Immunological exhaustion: How to make a disparate concept operational?
H Kaminski, M Lemoine, T Pradeu, S LeibundGut-Landmann |
PLoS pathogens | 2021 |
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NKG2D defines tumor‐reacting effector CD8 + T cells within tumor microenvironment
M Mojic, K Shitaoka, C Ohshima, S Ucche, F Lyu, H Hamana, H Tahara, H Kishi, Y Hayakawa |
Cancer Science | 2021 |
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Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment
F Ma, J Vayalil, G Lee, Y Wang, G Peng |
Journal for ImmunoTherapy of Cancer | 2021 |
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Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy
X Liu, CL Hartman, L Li, CJ Albert, F Si, A Gao, L Huang, Y Zhao, W Lin, EC Hsueh, L Shen, Q Shao, DF Hoft, DA Ford, G Peng |
Science Translational Medicine | 2021 |
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Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
LM McLane, SF Ngiow, Z Chen, J Attanasio, S Manne, G Ruthel, JE Wu, RP Staupe, W Xu, RK Amaravadi, X Xu, GC Karakousis, TC Mitchell, LM Schuchter, AC Huang, BD Freedman, MR Betts, EJ Wherry |
Cell Reports | 2021 |
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Rapid, label-free classification of tumor-reactive T cell killing with quantitative phase microscopy and machine learning
DN Kim, AA Lim, MA Teitell |
Scientific Reports | 2021 |
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TIM-3 in Leukemia; Immune Response and Beyond
M Rezaei, J Tan, C Zeng, Y Li, M Ganjalikhani-Hakemi |
Frontiers in Oncology | 2021 |
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Immune Functions of Signaling Lymphocytic Activation Molecule Family Molecules in Multiple Myeloma
M Ishibashi, R Morita, H Tamura |
Cancers | 2021 |
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The role of PD-1/PD-L1 checkpoint in arsenic lung tumorigenesis
W Xu, J Cui, L Wu, C He, G Chen |
Toxicology and Applied Pharmacology | 2021 |
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Latency-associated peptide identifies therapeutically resistant muscle-invasive bladder cancer with poor prognosis
R Ye, H Zeng, Z Liu, K Jin, C Liu, S Yan, Y Yu, R You, H Zhang, Y Chang, Y Wang, L Liu, Y Zhu, J Xu, L Xu, Z Wang |
Cancer Immunology, Immunotherapy | 2021 |
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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients
K de Jonge, L Tillé, J Lourenco, HM Hajjami, S Nassiri, J Racle, D Gfeller, M Delorenzi, G Verdeil, P Baumgaertner, DE Speiser |
OncoImmunology | 2021 |
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Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancer
W Wang, Y Zhong, Z Zhuang, J Xie, Y Lu, C Huang, Y Sun, L Wu, J Yin, H Yu, Z Jiang, S Wang, C Wang, Y Zhang, Y Huang, C Han, Z Zhong, J Hu, Y Ouyang, H Liu, M Yu, X Wei, D Chen, L Huang, Y Hou, Z Lin, S Liu, F Ling, X Yao |
Clinical and Translational Medicine | 2021 |
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Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma
W Deng, Y Ma, Z Su, Y Liu, P Liang, C Huang, X Liu, J Shao, Y Zhang, K Zhang, J Chen, R Li |
Molecular Therapy — Oncolytics | 2021 |
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In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?
I Esteban, C Pastor-Quiñones, L Usero, M Plana, F García, L Leal |
Viruses | 2021 |
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Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies?
S Aiello, F Casiraghi |
Cells | 2021 |
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Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells
N Sp, DY Kang, JM Lee, KJ Jang |
International journal of molecular sciences | 2021 |
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Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells
N Bannoud, T Dalotto-Moreno, L Kindgard, PA García, AG Blidner, KV Mariño, GA Rabinovich, DO Croci |
Frontiers in immunology | 2021 |
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Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia
DR Collins, JM Urbach, ZJ Racenet, U Arshad, KA Power, RM Newman, GH Mylvaganam, NL Ly, X Lian, A Rull, Y Rassadkina, AG Yanez, MJ Peluso, SG Deeks, F Vidal, M Lichterfeld, XG Yu, GD Gaiha, TM Allen, BD Walker |
Immunity | 2021 |
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Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients
K Jin, Y Cao, Y Gu, H Fang, Y Fei, J Wang, X Liu, K Lv, X He, C Lin, H Liu, H Li, H He, R Li, H Zhang, J Xu |
OncoImmunology | 2021 |
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WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression
M Wu, X Xia, J Hu, NW Fowlkes, S Li |
Nature Communications | 2021 |
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Activation or exhaustion of CD8+ T cells in patients with COVID-19
MS Rha, EC Shin |
Cellular and Molecular Immunology | 2021 |
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Using Elevated Cholesterol Synthesis as a Prognostic Marker in Wilms’ Tumor: A Bioinformatic Analysis
Y He, X Cui, Y Lin, Y Wang, D Wu, Y Fang, S Chutipongtanate |
BioMed Research International | 2021 |
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Distinct prognostic values of programmed death-ligand 1 and programmed cell death protein 1 in lung adenocarcinoma and squamous cell carcinoma patients
S Wang, X Qu, Z Li, X Che, L Cao, X Yang, X Hu, L Xu, K Hou, Y Fan, T Wen, Y Liu |
Annals of translational medicine | 2021 |
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Pivotal Role of Iron Homeostasis in the Induction of Mitochondrial Apoptosis by 6-Gingerol Through PTEN Regulated PD-L1 Expression in Embryonic Cancer Cells
N Sp, DY Kang, ES Jo, JM Lee, SW Bae, KJ Jang |
Frontiers in Oncology | 2021 |
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CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer?
AM Miggelbrink, JD Jackson, SJ Lorrey, ES Srinivasan, J Waibl-Polania, DS Wilkinson, PE Fecci |
Clinical cancer research | 2021 |
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BMPR2 expression level is correlated with low immune infiltration and predicts metastasis and poor survival in osteosarcoma
H Cao, S Quan, L Zhang, Y Chen, G Jiao |
Oncology Letters | 2021 |
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The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma
J Wang, M Huang, P Huang, J Zhao, J Tan, F Huang, R Ma, Y Xiao, G Deng, L Wei, Q Wei, Z Wang, S He, J Shen, S Sooranna, L Meng, J Song |
Frontiers in Oncology | 2021 |
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Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions
K Pansy, B Uhl, J Krstic, M Szmyra, K Fechter, A Santiso, L Thüminger, H Greinix, J Kargl, K Prochazka, J Feichtinger, AJ Deutsch |
International journal of molecular sciences | 2021 |
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Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
J Duraiswamy, R Turrini, A Minasyan, D Barras, I Crespo, A Grimm, J Casado, R Genolet, F Benedetti, A Wicky, K Ioannidou, W Castro, C Neal, A Moriot, S Renaud-Tissot, V Anstett, N Fahr, J Tanyi, M Eiva, C Jacobson, K Montone, M Westergaard, I Svane, L Kandalaft, M Delorenzi, P Sorger, A Färkkilä, O Michielin, V Zoete, S Carmona, P Foukas, D Powell, S Rusakiewicz, M Doucey, D Laniti, G Coukos |
Cancer Cell | 2021 |
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RKIP Pleiotropic Activities in Cancer and Inflammatory Diseases: Role in Immunity
R Touboul, S Baritaki, A Zaravinos, B Bonavida |
Cancers | 2021 |
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Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study
Vaes RD, Reynders K, Sprooten J, Nevola KT, Rouschop KM, Vooijs M, Garg AD, Lambrecht M, Hendriks LE, Rucevic M, De Ruysscher D |
Cancers | 2021 |
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Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer.
Liu B, Hu X, Feng K, Gao R, Xue Z, Zhang S, Zhang Y, Corse E, Hu Y, Han W, Zhang Z |
2021 | |
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CRISPR Screens to Identify Regulators of Tumor Immunity.
LaFleur MW, Sharpe AH |
Annual Review of Cancer Biology | 2021 |
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Tryptophan and its metabolites in normal physiology and cancer etiology
Perez-Castro L, Garcia R, Venkateswaran N, Barnes S, Conacci-Sorrell M |
The FEBS journal | 2021 |
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Advances in immune checkpoint inhibitors for hepatocellular carcinoma
Han JW, Park SH |
2021 | |
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Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
Xia Liu, Daniel Hoft, Guangyong Peng |
Journal of Clinical Investigation | 2020 |
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The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity
A Schnell, L Bod, A Madi, VK Kuchroo |
Cell Research | 2020 |
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Impact of checkpoint blockade on cancer vaccine–activated CD8+ T cell responses
PM Santos, J Adamik, TR Howes, S Du, L Vujanovic, S Warren, A Gambotto, JM Kirkwood, LH Butterfield |
Journal of Experimental Medicine | 2020 |
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Tumor microenvironmental influences on dendritic cell and T cell function: A focus on clinically relevant immunologic and metabolic checkpoints
KM Hargadon |
Clinical and Translational Medicine | 2020 |
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Contribution of Macrophages and T Cells in Skeletal Metastasis
V Mendoza-Reinoso, LK McCauley, PG Fournier |
Cancers | 2020 |
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Cellular and Molecular Mechanisms of CD8+ T Cell Differentiation, Dysfunction and Exhaustion
DJ Verdon, M Mulazzani, MR Jenkins |
International journal of molecular sciences | 2020 |
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Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28
FR Mariotti, L Quatrini, E Munari, P Vacca, N Tumino, G Pietra, MC Mingari, L Moretta |
British Journal of Pharmacology | 2020 |
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Emerging immunotherapies for metastasis
SC Edwards, WH Hoevenaar, SB Coffelt |
British Journal of Cancer | 2020 |
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Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?
A Ben-Shmuel, G Biber, M Barda-Saad |
Frontiers in immunology | 2020 |
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Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth
L Qin, R Zhao, D Chen, X Wei, Q Wu, Y Long, Z Jiang, Y Li, H Wu, X Zhang, Y Wu, S Cui, W Wei, H Yao, Z Liu, S Cao, Y Yao, Z Zhang, P Li |
Biomarker Research | 2020 |
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Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
MY Balkhi |
OncoImmunology | 2020 |
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TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals
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Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure
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Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer
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The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy
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LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-cultures
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Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities
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Immunomodulation with pomalidomide at early lymphocyte recovery after induction chemotherapy in newly diagnosed AML and high-risk MDS
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The Multifaceted Output of c-Jun Biological Activity: Focus at the Junction of CD8 T Cell Activation and Exhaustion
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Possibilities of Improving the Clinical Value of Immune Checkpoint Inhibitor Therapies in Cancer Care by Optimizing Patient Selection
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The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
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Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins
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The Landscape of CAR-T Cell Clinical Trials against Solid Tumors—A Comprehensive Overview
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Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology
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CAR Talk: How Cancer-Specific CAR T Cells Can Instruct How to Build CAR T Cells to Cure HIV
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Harnessing Radiation Biology to Augment Immunotherapy for Glioblastoma
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Prospective Immunophenotyping of CD8+ T Cells and Associated Clinical Outcomes of Patients With Oligometastatic Prostate Cancer Treated With Metastasis-Directed SBRT
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Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer
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Nature Immunology | 2019 |
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Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D
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Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion
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Cellular and Molecular Immunology | 2019 |
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Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma
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Current Opinion in Immunology | 2019 |
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Signatures of CD8+ T-cell dysfunction in AML patients and their reversibility with response to chemotherapy
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Nature Communications | 2018 |
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Cancer Cell | 2018 |
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Combination Immunotherapy: Taking Cancer Vaccines to the Next Level
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Frontiers in immunology | 2018 |
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Improving CAR-T cell Therapy of solid tumors with Oncolytic Virus-driven Production of a Bispecific T-cell Engager
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Frontiers in immunology | 2018 |
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Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients
J Yu, X Wu, J Yan, H Yu, L Xu, Z Chi, X Sheng, L Si, C Cui, J Dai, M Ma, T Xu, Y Kong, J Guo |
Journal of Hematology & Oncology | 2018 |
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Eradication of Established Tumors by Chemically Self-Assembled Nanoring (CSAN) Targeted T-cells
J Petersburg, J Shen, CM Csizmar, KA Murphy, J Spanier, K Gabrielse, TS Griffith, B Fife, CR Wagner |
ACS Nano | 2018 |
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Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway
CA Hartana, EA Bergman, AA Zirakzadeh, D Krantz, ME Winerdal, M Winerdal, M Johansson, F Alamdari, T Jakubczyk, H Glise, K Riklund, A Sherif, O Winqvist, H Shiku |
PloS one | 2018 |
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Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
B Bengsch, T Ohtani, O Khan, M Setty, S Manne, S OBrien, PF Gherardini, RS Herati, AC Huang, KM Chang, EW Newell, N Bovenschen, D Peer, SM Albelda, EJ Wherry |
Immunity | 2018 |
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T Cell Calcium Signaling Regulation by the Co-Receptor CD5
C Freitas, D Johnson, K Weber |
International journal of molecular sciences | 2018 |
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Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy
N Dumauthioz, S Labiano, P Romero |
Frontiers in immunology | 2018 |
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A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
DS Thommen, VH Koelzer, P Herzig, A Roller, M Trefny, S Dimeloe, A Kiialainen, J Hanhart, C Schill, C Hess, SS Prince, M Wiese, D Lardinois, PC Ho, C Klein, V Karanikas, KD Mertz, TN Schumacher, A Zippelius |
Nature Medicine | 2018 |
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Metastatic Melanoma: Recent Therapeutic Progress and Future Perspectives
N Malissen, JJ Grob |
Drugs | 2018 |
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Immune cell profiling in the age of immune checkpoint inhibitors: implications for biomarker discovery and understanding of resistance mechanisms
SY Lim, H Rizos |
Mammalian Genome | 2018 |
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YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells
MY Balkhi, G Wittmann, F Xiong, RP Junghans |
iScience | 2018 |
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Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
Y Zhao, DL Harrison, Y Song, J Ji, J Huang, E Hui |
Cell Reports | 2018 |
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Combining radiation plus immunotherapy to improve systemic immune response
TR Cushman, D Gomez, R Kumar, A Likacheva, JY Chang, AP Cadena, S Paris, JW Welsh |
Journal of Thoracic Disease | 2018 |
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TIM-3 Regulates CD103 + Dendritic Cell Function and Response to Chemotherapy in Breast Cancer
Á de Mingo Pulido, A Gardner, S Hiebler, H Soliman, HS Rugo, MF Krummel, LM Coussens, B Ruffell |
Cancer Cell | 2018 |
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Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels
D Nair, E Rådestad, P Khalkar, N Diaz-Argelich, A Schröder, C Klynning, J Ungerstedt, M Uhlin, AP Fernandes |
Frontiers in Oncology | 2018 |
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Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy
S Lin, G Huang, L Cheng, Z Li, Y Xiao, Q Deng, Y Jiang, B Li, S Lin, S Wang, Q Wu, H Yao, S Cao, Y Li, P Liu, W Wei, D Pei, Y Yao, Z Wen, X Zhang, Y Wu, Z Zhang, S Cui, X Sun, X Qian, P Li |
mAbs | 2018 |
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Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells
F Salerno, A Guislain, JJ Heeren, BP Nicolet, HA Young, MC Wolkers |
OncoImmunology | 2018 |
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A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma
Y Cai, F Wang, Q Liu, Z Li, D Li, Z Sun |
Investigational New Drugs | 2018 |
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CD28H expression identifies resident memory CD8 + T cells with less cytotoxicity in human peripheral tissues and cancers
Y Tian, Y Sun, F Gao, MR Koenig, A Sunderland, Y Fujiwara, RJ Torphy, L Chen, BH Edil, RD Schulick, Y Zhu |
OncoImmunology | 2018 |
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Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC
AE Oja, B Piet, D van der Zwan, H Blaauwgeers, M Mensink, S de Kivit, J Borst, MA Nolte, RA van Lier, R Stark, P Hombrink |
Frontiers in immunology | 2018 |
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Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells
R Radpour, F Forouharkhou |
World journal of stem cells | 2018 |
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The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment
L Agresta, KH Hoebe, EM Janssen |
Frontiers in immunology | 2018 |
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Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma
K Lemdani, N Mignet, V Boudy, J Seguin, E Oujagir, O Bawa, F Peschaud, JF Emile, C Capron, R Malafosse |
OncoImmunology | 2018 |
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Transient stimulation expands superior antitumor T cells for adoptive therapy
Yuki Kagoya, Munehide Nakatsugawa, Toshiki Ochi, Yuchen Cen, Tingxi Guo, Mark Anczurowski, Kayoko Saso, Marcus Butler, Naoto Hirano |
JCI Insight | 2017 |
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Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer
Fumi Sato-Kaneko, Shiyin Yao, Alast Ahmadi, Shannon S. Zhang, Tadashi Hosoya, Megan M. Kaneda, Judith A. Varner, Minya Pu, Karen Messer, Cristiana Guiducci, Robert L. Coffman, Kazutaka Kitaura, Takaji Matsutani, Ryuji Suzuki, Dennis A Carson, Tomoko Hayashi, Ezra Cohen |
JCI Insight | 2017 |
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Trigger-happy resident memory CD4+ T cells inhabit the human lungs
AE Oja, B Piet, C Helbig, R Stark, D der Zwan, H Blaauwgeers, EB Remmerswaal, D Amsen, RE Jonkers, PD Moerland, MA Nolte, RA van Lier, P Hombrink |
Mucosal Immunology | 2017 |
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Marburg- and Ebolaviruses: From Ecosystems to Molecules
E Mühlberger, LL Hensley, JS Towner |
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Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma
LE Lucca, DA Hafler |
Immunological Reviews | 2017 |
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Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
JG Crompton, N Klemen, US Kammula |
Annals of Surgical Oncology | 2017 |
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T memory stem cells in health and disease
L Gattinoni, DE Speiser, M Lichterfeld, C Bonini |
Nature Medicine | 2017 |
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Is immunotherapy here to stay in multiple myeloma?
P Rodríguez-Otero, B Paiva, M Engelhardt, F Prósper, JF san Miguel |
Haematologica | 2017 |
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T cell exhaustion: from pathophysiological basics to tumor immunotherapy
K Catakovic, E Klieser, D Neureiter, R Geisberger |
Cell Communication and Signaling | 2017 |
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Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy
S Gnjatic, V Bronte, LR Brunet, MO Butler, ML Disis, J Galon, LG Hakansson, BA Hanks, V Karanikas, SN Khleif, JM Kirkwood, LD Miller, DJ Schendel, I Tanneau, JM Wigginton, LH Butterfield |
Journal for ImmunoTherapy of Cancer | 2017 |
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Increased PD-1 + and TIM-3 + TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients
HB Jie, RM Srivastava, A Argiris, JE Bauman, LP Kane, RL Ferris |
Cancer immunology research | 2017 |
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Programmed Cell Death-1/Programmed Death-ligand 1 Pathway: A New Target for Sepsis
Q Liu, CS Li |
Chinese Medical Journal | 2017 |
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Virus-Specific CD8 + T Cells Infiltrate Melanoma Lesions and Retain Function Independently of PD-1 Expression
DA Erkes, CJ Smith, NA Wilski, S Caldeira-Dantas, T Mohgbeli, CM Snyder |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
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CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond
ZN Chang, YY Chen |
Trends in Molecular Medicine | 2017 |
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The challenges of solid tumor for designer CAR-T therapies: a 25-year perspective
RP Junghans |
Cancer Gene Therapy | 2017 |
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Transcriptional and epigenetic regulation of T cell hyporesponsiveness
RM Pereira, PG Hogan, A Rao, GJ Martinez |
Journal of leukocyte biology | 2017 |
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Functional Expression of Programmed Death-Ligand 1 (B7-H1) by Immune Cells and Tumor Cells
RM Johnson, H Dong |
Frontiers in immunology | 2017 |
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Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir
JL Riley, LJ Montaner |
The Journal of Infectious Diseases | 2017 |
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Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells
T Moore, CR Wagner, GM Scurti, KA Hutchens, C Godellas, AL Clark, EM Kolawole, LM Hellman, NK Singh, FA Huyke, SY Wang, KM Calabrese, HD Embree, R Orentas, K Shirai, E Dellacecca, E Garrett-Mayer, M Li, JM Eby, PJ Stiff, BD Evavold, BM Baker, IC Poole, B Dropulic, JI Clark, MI Nishimura |
Cancer Immunology, Immunotherapy | 2017 |
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LAG3 (CD223) as a cancer immunotherapy target
LP Andrews, AE Marciscano, CG Drake, DA Vignali |
Immunological Reviews | 2017 |
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Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
IS Okoye, M Houghton, L Tyrrell, K Barakat, S Elahi |
Frontiers in immunology | 2017 |
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Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor Immunity
KP Yeo, V Angeli |
Frontiers in immunology | 2017 |
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TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action
W Du, M Yang, A Turner, C Xu, R Ferris, J Huang, L Kane, B Lu |
International journal of molecular sciences | 2017 |
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T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
E Hui, J Cheung, J Zhu, X Su, MJ Taylor, HA Wallweber, DK Sasmal, J Huang, JM Kim, I Mellman, RD Vale |
Science | 2017 |
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Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies
KG Anderson, IM Stromnes, PD Greenberg |
Cancer Cell | 2017 |
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Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries
PC Ho, SM Kaech |
Current Opinion in Immunology | 2017 |
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Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice
W Jing, JA Gershan, GC Blitzer, K Palen, J Weber, L McOlash, M Riese, BD Johnson |
Journal for ImmunoTherapy of Cancer | 2017 |
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Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
AP Ganesan, J Clarke, O Wood, EM Garrido-Martin, SJ Chee, T Mellows, D Samaniego-Castruita, D Singh, G Seumois, A Alzetani, E Woo, PS Friedmann, EV King, GJ Thomas, T Sanchez-Elsner, P Vijayanand, CH Ottensmeier |
Nature Immunology | 2017 |
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EP4 Antagonism by E7046 Diminishes Myeloid Immunosuppression and Synergizes with Treg-reducing IL-2-Diphtheria Toxin Fusion Protein in Restoring Anti-tumor Immunity
DI Albu, Z Wang, KC Huang, J Wu, N Twine, S Leacu, C Ingersoll, L Parent, W Lee, D Liu, R Wright-Michaud, N Kumar, G Kuznetsov, Q Chen, W Zheng, K Nomoto, M Woodall-Jappe, X Bao |
OncoImmunology | 2017 |
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RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma
DC Harrer, B Simon, S Fujii, K Shimizu, U Uslu, G Schuler, KF Gerer, S Hoyer, J Dörrie, N Schaft |
BMC Cancer | 2017 |
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The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8 + T cells in the tumor microenvironment
JB Williams, BL Horton, Y Zheng, Y Duan, JD Powell, TF Gajewski |
Journal of Experimental Medicine | 2017 |
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Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response
Q Xue, E Bettini, P Paczkowski, C Ng, A Kaiser, T McConnell, O Kodrasi, MF Quigley, J Heath, R Fan, S Mackay, ME Dudley, SH Kassim, J Zhou |
Journal for ImmunoTherapy of Cancer | 2017 |
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Molecular Dissection of CD8 + T-Cell Dysfunction
C Wang, M Singer, AC Anderson |
Trends in Immunology | 2017 |
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Lymphatic vessels regulate immune microenvironments in human and murine melanoma
Amanda Lund, Marek Wagner, Manuel Fankhauser, Eli Steinskog, Maria Broggi, Stefani Spranger, Thomas Gajewski, Kari Alitalo, Hans Eikesdal, Helge Wiig, Melody A. Swartz |
Journal of Clinical Investigation | 2016 |
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Tumor Infiltrating Lymphocytes are Dynamically Desensitiized to Antigen but are Maintained by Homeostatic Cytokine
Bijan Boldajipour, Amanda Nelson, Matthew Krummel |
JCI Insight | 2016 |
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Inter-lesional diversity of T-cell receptors in melanoma with immune-checkpoints enriched in tissue-resident memory T cells
ChandraSekhar Boddupalli, Noffar Bar, Krishna Kadaveru, Michael Krauthammer, Natapol pornputtapong, Zifeng Mai, Stephan Ariyan, Deepak Narayan, Harriet Kluger, Yanhong Deng, Rakesh Verma, Rituparna Das, Antonella Bacchiocchi, Ruth Halaban, Mario Sznol, Madhav Dhodapkar, kavita Dhodapkar |
JCI Insight | 2016 |
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Regulatory circuits of T cell function in cancer
DE Speiser, PC Ho, G Verdeil |
Nature Reviews Immunology | 2016 |
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Reversing T-cell Dysfunction and Exhaustion in Cancer
HM Zarour |
Clinical cancer research | 2016 |
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Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
A Gros, MR Parkhurst, E Tran, A Pasetto, PF Robbins, S Ilyas, TD Prickett, JJ Gartner, JS Crystal, IM Roberts, K Trebska-McGowan, JR Wunderlich, JC Yang, SA Rosenberg |
Nature Medicine | 2016 |
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Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System
DC Deniger, A Pasetto, E Tran, MR Parkhurst, CJ Cohen, PF Robbins, LJ Cooper, SA Rosenberg |
Molecular Therapy | 2016 |
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Implications of Lymphatic Transport to Lymph Nodes in Immunity and Immunotherapy
SN Thomas, NA Rohner, EE Edwards |
Annual Review of Biomedical Engineering | 2016 |
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T‐cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases
EF McKinney, KG Smith |
Immunology and Cell Biology | 2016 |
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Effector, Memory, and Dysfunctional CD8 + T Cell Fates in the Antitumor Immune Response
J Reiser, A Banerjee |
Journal of Immunology Research | 2016 |
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Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells
H Saito, K Okita, N Fusaki, MS Sabel, AE Chang, F Ito |
Stem Cells International | 2016 |
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Molecular Profile of Tumor-Specific CD8+ T Cell Hypofunction in a Transplantable Murine Cancer Model
KA Waugh, SM Leach, BL Moore, TC Bruno, JD Buhrman, JE Slansky |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
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Systemic and intratumoral balances between monocytes/macrophages and lymphocytes predict prognosis in hepatocellular carcinoma patients after surgery
R Liao, N Jiang, ZW Tang, DW Li, P Huang, SQ Luo, JP Gong, CY Du |
Oncotarget | 2016 |
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Tolerance of Tumor-Specific T cells in Melanoma Metastases
KA Waugh, SM Leach |
Journal of Clinical & Cellular Immunology | 2016 |
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PD-1/PD-L1 blockade enhances T cell activity and antitumor efficacy of imatinib in gastrointestinal stromal tumors
AM Seifert, S Zeng, JQ Zhang, TS Kim, NA Cohen, MJ Beckman, BD Medina, JH Maltbaek, JK Loo, MH Crawley, F Rossi, P Besmer, CR Antonescu, RP DeMatteo |
Clinical cancer research | 2016 |
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Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy
S Qi, H Li, L Lu, Z Qi, L Liu, L Chen, G Shen, L Fu, Q Luo, Z Zhang |
eLife | 2016 |
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Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory
H Saito, K Okita, AE Chang, F Ito |
Cancer research | 2016 |
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Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis
XJ Guo, P Dash, M Calverley, S Tomchuck, MH Dallas, PG Thomas |
Molecular Therapy — Methods & Clinical Development | 2016 |
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Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation
J Godec, Y Tan, A Liberzon, P Tamayo, S Bhattacharya, AJ Butte, JP Mesirov, WN Haining |
Immunity | 2016 |
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
I Tirosh, B Izar, SM Prakadan, MH Wadsworth, D Treacy, JJ Trombetta, A Rotem, C Rodman, C Lian, G Murphy, M Fallahi-Sichani, K Dutton-Regester, JR Lin, O Cohen, P Shah, D Lu, AS Genshaft, TK Hughes, CG Ziegler, SW Kazer, A Gaillard, KE Kolb, AC Villani, CM Johannessen, AY Andreev, EM van Allen, M Bertagnolli, PK Sorger, RJ Sullivan, KT Flaherty, DT Frederick, J Jane-Valbuena, CH Yoon, O Rozenblatt-Rosen, AK Shalek, A Regev, LA Garraway |
Science | 2016 |
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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
A Schietinger, M Philip, VE Krisnawan, EY Chiu, JJ Delrow, RS Basom, P Lauer, DG Brockstedt, SE Knoblaugh, GJ Hämmerling, TD Schell, N Garbi, PD Greenberg |
Immunity | 2016 |
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Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis
N Jacquelot, MP Roberti, DP Enot, S Rusakiewicz, M Semeraro, S Jégou, C Flores, L Chen, BS Kwon, C Borg, B Weide, F Aubin, S Dalle, H Kohrt, M Ayyoub, G Kroemer, A Marabelle, A Cavalcanti, A Eggermont, L Zitvogel |
Journal of Investigative Dermatology | 2016 |
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Immunobiology and immunosurveillance in patients with intraductal papillary mucinous neoplasms (IPMNs), premalignant precursors of pancreatic adenocarcinomas
PL Beatty, R der Geest, JG Hashash, T Kimura, D Gutkin, RE Brand, OJ Finn |
Cancer Immunology, Immunotherapy | 2016 |
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Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment
S Spranger |
International Immunology | 2016 |
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Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
PC Ho, PS Liu |
Journal for ImmunoTherapy of Cancer | 2016 |
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Adoptive T cell transfer: Imagining the next generation of cancer immunotherapies
L Gattinoni |
Seminars in Immunology | 2016 |
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A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
M Singer, C Wang, L Cong, ND Marjanovic, MS Kowalczyk, H Zhang, J Nyman, K Sakuishi, S Kurtulus, D Gennert, J Xia, JY Kwon, J Nevin, RH Herbst, I Yanai, O Rozenblatt-Rosen, VK Kuchroo, A Regev, AC Anderson |
Cell | 2016 |
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Molecular Programming of Tumor-Infiltrating CD8+ T Cells and IL15 Resistance
AL Doedens, MP Rubinstein, ET Gross, JA Best, DH Craig, MK Baker, DJ Cole, JD Bui, AW Goldrath |
Cancer immunology research | 2016 |
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Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer
JJ Bastman, HS Serracino, Y Zhu, MR Koenig, V Mateescu, SB Sams, KD Davies, CD Raeburn, RC McIntyre, BR Haugen, JD French |
The Journal of clinical endocrinology and metabolism | 2016 |
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Expression of the galectin-9‑Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma
Z Liu, H Han, X He, S Li, C Wu, C Yu, S Wang |
Oncology Letters | 2016 |
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CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade
H Yan, X Hou, T Li, L Zhao, X Yuan, H Fu, R Zhu |
Tumor Biology | 2016 |
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Immune signatures of protective spleen memory CD8 T cells
L Brinza, S Djebali, M Tomkowiak, J Mafille, C Loiseau, PE Jouve, S Bernard, L Buffat, B Lina, M Ottmann, M Rosa-Calatrava, S Schicklin, N Bonnefoy, G Lauvau, M Grau, M Wencker, C Arpin, T Walzer, Y Leverrier, J Marvel |
Scientific Reports | 2016 |
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Wilms tumor 1 peptide vaccination after hematopoietic stem cell transplant in leukemia patients
N Hosen, T Maeda, Y Hashii, A Tsuboi, S Nishida, J Nakata, Y Oji, Y Oka, H Sugiyama |
Stem Cell Investigation | 2016 |
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Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, December 5th 2015
Ascierto PA, Ascierto ML, Formenti S, Gnjatic S, Hammers H, Hirsh V, Kiessling R, Melero I, Nanda R, Pawelec G, Pignata S, Romero P, Speiser DE, Fox BA, Marincola FM |
Journal for ImmunoTherapy of Cancer | 2016 |
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Eternal fight between good and evil: immunity, inflammation and cancer
Shabnam Shalapour, Michael Karin |
Journal of Clinical Investigation | 2015 |
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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
PK Gupta, J Godec, D Wolski, E Adland, K Yates, KE Pauken, C Cosgrove, C Ledderose, WG Junger, SC Robson, EJ Wherry, G Alter, PJ Goulder, P Klenerman, AH Sharpe, GM Lauer, WN Haining, DC Douek |
PLoS pathogens | 2015 |
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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
CH Chang, J Qiu, D OSullivan, MD Buck, T Noguchi, JD Curtis, Q Chen, M Gindin, MM Gubin, GJ van der Windt, E Tonc, RD Schreiber, EJ Pearce, EL Pearce |
Cell | 2015 |
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Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy
A Śledzińska, L Menger, K Bergerhoff, KS Peggs, SA Quezada |
Molecular Oncology | 2015 |
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PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation
Y Kong, J Zhang, DF Claxton, WC Ehmann, WB Rybka, L Zhu, H Zeng, TD Schell, H Zheng |
Blood Cancer Journal | 2015 |
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Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?
MN Roufaiel, JW Wells, RJ Steptoe |
Frontiers in immunology | 2015 |
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Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture
V Janelle, C Carli, J Taillefer, J Orio, JS Delisle |
Journal of Translational Medicine | 2015 |
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Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B
M Grange, M Giordano, A Mas, R Roncagalli, G Firaguay, JA Nunes, J Ghysdael, AM Schmitt-Verhulst, N Auphan-Anezin |
Immunology | 2015 |
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Consensus nomenclature for CD8 + T cell phenotypes in cancer
L Apetoh, MJ Smyth, CG Drake, JP Abastado, RN Apte, M Ayyoub, JY Blay, M Bonneville, LH Butterfield, A Caignard, C Castelli, F Cavallo, E Celis, L Chen, MP Colombo, B Comin-Anduix, G Coukos, MV Dhodapkar, G Dranoff, IH Frazer, WH Fridman, DI Gabrilovich, E Gilboa, S Gnjatic, D Jäger, P Kalinski, HL Kaufman, R Kiessling, J Kirkwood, A Knuth, R Liblau, MT Lotze, E Lugli, F Marincola, I Melero, CJ Melief, TR Mempel, EA Mittendorf, K Odun, WW Overwijk, AK Palucka, G Parmiani, A Ribas, P Romero, RD Schreiber, G Schuler, PK Srivastava, E Tartour, D Valmori, SH van der Burg, P der Bruggen, BJ van Eynde, E Wang, W Zou, TL Whiteside, DE Speiser, DM Pardoll, NP Restifo, AC Anderson |
OncoImmunology | 2015 |
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The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
HE Barker, JT Paget, AA Khan, KJ Harrington |
Nature Reviews Cancer | 2015 |
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New clinical advances in immunotherapy for the treatment of solid tumours
VA Zavala, AM Kalergis |
Immunology | 2015 |
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Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity
K Waugh, S Leach, J Slansky |
Human vaccines | 2015 |
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Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma
M Dey, AL Chang, J Miska, DA Wainwright, AU Ahmed, IV Balyasnikova, P Pytel, Y Han, A Tobias, L Zhang, J Qiao, MS Lesniak |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection
JH Chen, CJ Perry, YC Tsui, MM Staron, IA Parish, CX Dominguez, DW Rosenberg, SM Kaech |
Nature Medicine | 2015 |
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Overcoming T cell exhaustion in infection and cancer
KE Pauken, EJ Wherry |
Trends in Immunology | 2015 |
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Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway
J Lee, E Ahn, HT Kissick, R Ahmed |
Forum on immunopathological diseases and therapeutics | 2015 |
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Inhibitory Receptors Beyond T Cell Exhaustion
SA Marraco, NJ Neubert, G Verdeil, DE Speiser |
Frontiers in immunology | 2015 |
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BTLA marks a less-differentiated tumor-infiltrating lymphocyte subset in melanoma with enhanced survival properties
CL Haymaker, RC Wu, K Ritthipichai, C Bernatchez, MA Forget, JQ Chen, H Liu, E Wang, F Marincola, P Hwu, LG Radvanyi |
OncoImmunology | 2015 |
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Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression
AS Japp, MA Kursunel, S Meier, JN Mälzer, X Li, NA Rahman, W Jekabsons, H Krause, A Magheli, C Klopf, A Thiel, M Frentsch |
Cancer Immunology, Immunotherapy | 2015 |
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PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer
JJ Severson, HS Serracino, V Mateescu, CD Raeburn, RC McIntyre, SB Sams, BR Haugen, JD French |
Cancer immunology research | 2015 |
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Prevalence of tumor-infiltrating lymphocytes and PD-L1 expression in the soft tissue sarcoma microenvironment
SP D’Angelo, AN Shoushtari, NP Agaram, D Kuk, LX Qin, RD Carvajal, MA Dickson, M Gounder, ML Keohan, GK Schwartz, WD Tap |
Human Pathology | 2015 |
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Data analysis as a source of variability of the HLA-peptide multimer assay: from manual gating to automated recognition of cell clusters
C Gouttefangeas, C Chan, S Attig, TT Køllgaard, HG Rammensee, S Stevanović, D Wernet, P Straten, MJ Welters, C Ottensmeier, SH van der Burg, CM Britten |
Cancer Immunology, Immunotherapy | 2015 |
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Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma
W Jing, JA Gershan, J Weber, D Tlomak, L McOlash, C Sabatos-Peyton, BD Johnson |
Journal for ImmunoTherapy of Cancer | 2015 |
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VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors
T Voron, O Colussi, E Marcheteau, S Pernot, M Nizard, AL Pointet, S Latreche, S Bergaya, N Benhamouda, C Tanchot, C Stockmann, P Combe, A Berger, F Zinzindohoue, H Yagita, E Tartour, J Taieb, M Terme |
Journal of Experimental Medicine | 2015 |
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Association between polymorphisms in the promoter region of T cell immunoglobulin and mucin domain-3 and myasthenia gravis-associated thymoma
G Xu, K Zheng, X Lu, J Wang, Y Chai, J Wang |
Oncology Letters | 2015 |
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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
AH Long, WM Haso, JF Shern, KM Wanhainen, M Murgai, M Ingaramo, JP Smith, AJ Walker, ME Kohler, VR Venkateshwara, RN Kaplan, GH Patterson, TJ Fry, RJ Orentas, CL Mackall |
Nature Medicine | 2015 |
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T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment
FM Schnorfeil, FS Lichtenegger, K Emmerig, M Schlueter, JS Neitz, R Draenert, W Hiddemann, M Subklewe |
Journal of Hematology & Oncology | 2015 |
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T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection
EF McKinney, JC Lee, DR Jayne, PA Lyons, KG Smith |
Nature | 2015 |
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Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients
SJ Felts, VP van Keulen, AD Scheid, KS Allen, RK Bradshaw, J Jen, T Peikert, S Middha, Y Zhang, MS Block, SN Markovic, LR Pease |
Cancer Immunology, Immunotherapy | 2015 |
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GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway
B Mahata, S Biswas, P Rayman, A Chahlavi, J Ko, A Bhattacharjee, YT Li, Y Li, T Das, G Sa, B Raychaudhuri, MA Vogelbaum, C Tannenbaum, JH Finke, K Biswas, N Gangopadhyay |
PloS one | 2015 |
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Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion
M Giordano, C Henin, J Maurizio, C Imbratta, P Bourdely, M Buferne, L Baitsch, L Vanhille, MH Sieweke, DE Speiser, N Auphan-Anezin, AM Schmitt-Verhulst, G Verdeil |
The EMBO Journal | 2015 |
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PD-1 Blockade Can Restore Functions of T-Cells in Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma In Vitro
L Quan, X Chen, A Liu, Y Zhang, X Guo, S Yan, Y Liu, L Zhang |
PloS one | 2015 |
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Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab
SS Kwek, J Lewis, L Zhang, V Weinberg, SK Greaney, AL Harzstark, AM Lin, CJ Ryan, EJ Small, L Fong |
Cancer immunology research | 2015 |
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Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages
A Kakizaki, T Fujimura, S Furudate, Y Kambayashi, T Yamauchi, H Yagita, S Aiba |
OncoImmunology | 2015 |
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New strategies of DLI in the management of relapse of hematological malignancies after allogeneic hematopoietic SCT
X Chang, X Zang, CQ Xia |
Bone Marrow Transplantation | 2015 |
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Elevated preoperative aspartate aminotransferase to lymphocyte ratio index as an independent prognostic factor for patients with hepatocellular carcinoma after hepatic resection
J Jin, P Zhu, Y Liao, J Li, W Liao, S He |
Oncotarget | 2015 |
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Immunotherapy in Melanoma, Gastrointestinal (GI), and Pulmonary Malignancies
AB Dillon, K Lin, A Kwong, S Ortiz |
AIMS Public Health | 2015 |
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Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death
Rao E, Zhang Y, Zhu G, Hao J, Persson XM, Egilmez NK, Suttles J, Li B |
Oncotarget | 2015 |
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PD-1 identifies the diverse repertoire of tumor-reactive and mutation-specific lymphocytes in human tumors
Alena Gros, Paul F. Robbins, Xin Yao, Yong Li, Simon Turcotte, Eric Tran, John R Wunderlich, Arnold Mixon, Shawn Farid, Mark Dudley, Ken-ichi Hanada, Jorge R. Almeida, Sam Darko, Daniel C. Douek, James Yang, Steven Rosenberg |
Journal of Clinical Investigation | 2014 |
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Dynamic regulatory T cell-APC interactions locally promote intratumoral CTL dysfunction
Christian Bauer, Edward Kim, Francesco Marangoni, Esteban Carrizosa, Natalie Claudio, Thorsten Mempel |
Journal of Clinical Investigation | 2014 |
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Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade
IP da Silva, A Gallois, S Jimenez-Baranda, S Khan, AC Anderson, VK Kuchroo, I Osman, N Bhardwaj |
Cancer immunology research | 2014 |
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Immune-Based Antitumor Effects of BRAF Inhibitors Rely on Signaling by CD40L and IFN
PC Ho, KM Meeth, YC Tsui, B Srivastava, MW Bosenberg, SM Kaech |
Cancer research | 2014 |
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Targeting T Cell Immunometabolism for Cancer Immunotherapy; Understanding the Impact of the Tumor Microenvironment
MB Mockler, MJ Conroy, J Lysaght |
Frontiers in Oncology | 2014 |
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MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial
E Romano, O Michielin, V Voelter, J Laurent, H Bichat, A Stravodimou, P Romero, DE Speiser, F Triebel, S Leyvraz, A Harari |
Journal of Translational Medicine | 2014 |
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Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
Y Lu, B Hong, H Li, Y Zheng, M Zhang, S Wang, J Qian, Q Yi |
Proceedings of the National Academy of Sciences | 2014 |
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Reprogramming antitumor immunity
JG Crompton, D Clever, R Vizcardo, M Rao, NP Restifo |
Trends in Immunology | 2014 |
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The Effect of Adjuvanting Cancer Vaccines with Herpes Simplex Virus Glycoprotein D on Melanoma-Driven CD8+ T Cell Exhaustion
Y Zhang, HC Ertl |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children
MA Shevtsov, AV Kim, KA Samochernych, IV Romanova, BA Margulis, IV Guzhova, IV Yakovenko, AM Ischenko, WA Khachatryan |
OncoTargets and therapy | 2014 |
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The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
MM Staron, SM Gray, HD Marshall, IA Parish, JH Chen, CJ Perry, G Cui, MO Li, SM Kaech |
Immunity | 2014 |
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ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells
S Guedan, X Chen, A Madar, C Carpenito, SE McGettigan, MJ Frigault, J Lee, AD Posey, J Scholler, N Scholler, R Bonneau, CH June |
Blood | 2014 |
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Clinical blockade of PD1 and LAG3 — potential mechanisms of action
LT Nguyen, PS Ohashi |
Nature Reviews Immunology | 2014 |
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TNF- -Dependent Hematopoiesis following Bcl11b Deletion in T Cells Restricts Metastatic Melanoma
MN Uddin, Y Zhang, JA Harton, KC MacNamara, D Avram |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?
DE Speiser, DT Utzschneider, SG Oberle, C Münz, P Romero, D Zehn |
Nature Reviews Immunology | 2014 |
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OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells To Exit Quiescence
SL Buchan, T Manzo, B Flutter, A Rogel, N Edwards, L Zhang, S Sivakumaran, S Ghorashian, B Carpenter, CL Bennett, GJ Freeman, M Sykes, M Croft, A Al-Shamkhani, R Chakraverty |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity
DA Erkes, SR Selvan |
Journal of Immunology Research | 2014 |
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Regulation of T cell responses by the receptor molecule Tim-3
JV Gorman, JD Colgan |
Immunologic Research | 2014 |
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Cancer immunotherapy drives implementation science in oncology
DE Speiser, L Flatz |
Human Vaccines & Immunotherapeutics | 2014 |
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Transplanted terminally differentiated induced pluripotent stem cells are accepted by immune mechanisms similar to self-tolerance
PE de Almeida, EH Meyer, NG Kooreman, S Diecke, D Dey, V Sanchez-Freire, S Hu, A Ebert, J Odegaard, NM Mordwinkin, TP Brouwer, D Lo, DT Montoro, MT Longaker, RS Negrin, JC Wu |
Nature Communications | 2014 |
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Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics
JG Crompton, M Sukumar, R Roychoudhuri, D Clever, A Gros, R Eil, E Tran, K Hanada, Z Yu, DC Palmer, SP Kerkar, RD Michalek, T Upham, A Leonardi, N Aquavella, E Wang, FM Marincola, L Gattinoni, P Muranski, MS Sundrud, CA Klebanoff, SA Rosenberg, DT Fearon, NP Restifo |
2014 | |
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Pathogen-Driven Cancers and Emerging Immune Therapeutic Strategies
N Vandeven, P Nghiem |
Cancer immunology research | 2014 |
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Melanoma progression is associated with NK cell exhaustion
Pires da Silva I, Gallois A, Jimenez-Baranda S, Anderson A, Kuchroo V, Osman I, Bhardwaj N |
Journal for ImmunoTherapy of Cancer | 2014 |
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Myeloid-derived suppressor cells and their role in CTLA-4 blockade therapy
Pico de Coaña Y, Masucci G, Hansson J, Kiessling R |
Cancer Immunology, Immunotherapy | 2014 |
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Sprouty-2 regulates HIV-specific T cell polyfunctionality
Yen-Ling Chiu, Liang Shan, Hai-Liang Huang, Carl Haupt, Catherine Bessell, David Canaday, Hao Zhang, Ya-Chi Ho, Jonathan Powell, Mathias Oelke, Joseph Margolick, Joel Blankson, Diane E. Griffin, Jonathan Schneck |
Journal of Clinical Investigation | 2013 |
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Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression
YC Lu, X Yao, YF Li, M El-Gamil, ME Dudley, JC Yang, JR Almeida, DC Douek, Y Samuels, SA Rosenberg, PF Robbins |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Local administration of TLR ligands rescues the function of tumor-infiltrating CD8 T cells and enhances the antitumor effect of lentivector immunization
H Xiao, Y Peng, Y Hong, L Huang, ZS Guo, DL Bartlett, N Fu, DH Munn, A Mellor, Y He |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Reversal of in situ T cell exhaustion during effective human anti-leukemia responses to donor lymphocyte infusion
P Bachireddy, U Hainz, M Rooney, O Pozdnyakova, J Aldridge, W Zhang, X Liao, FS Hodi, K O'Connell, WN Haining, NR Goldstein, CM Canning, RJ Soiffer, J Ritz, N Hacohen, EP 3rd, HT Kim, CJ Wu |
Blood | 2013 |
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Fas expression by tumor stroma is required for cancer eradication
JJ Listopad, T Kammertoens, K Anders, B Silkenstedt, G Willimsky, K Schmidt, AA Kuehl, C Loddenkemper, T Blankenstein |
Proceedings of the National Academy of Sciences | 2013 |
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Novel antibodies targeting immune regulatory checkpoints for cancer therapy
CS Lee, M Cragg, M Glennie, P Johnson |
British Journal of Clinical Pharmacology | 2013 |
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Strategies to reverse melanoma-induced T-cell dysfunction
J Fourcade, HM Zarour |
Clinics in Dermatology | 2013 |
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Tolerance and exhaustion: defining mechanisms of T cell dysfunction
A Schietinger, PD Greenberg |
Trends in Immunology | 2013 |
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The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses
H Frebel, A Oxenius |
Trends in Immunology | 2013 |
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Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
M Kalos, CH June |
Immunity | 2013 |
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Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection
JC Cyktor, B Carruthers, GL Beamer, J Turner |
PloS one | 2013 |
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Immunotherapy-induced CD8+ T Cells Instigate Immune Suppression in the Tumor
AJ McGray, R Hallett, D Bernard, SL Swift, Z Zhu, F Teoderascu, H VanSeggelen, JA Hassell, AA Hurwitz, Y Wan, JL Bramson |
Molecular Therapy | 2013 |
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T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
J Crespo, H Sun, TH Welling, Z Tian, W Zou |
Current Opinion in Immunology | 2013 |
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Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes
D Abate-Daga, K Hanada, JL Davis, JC Yang, SA Rosenberg, RA Morgan |
Blood | 2013 |
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Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells
A Legat, DE Speiser, H Pircher, D Zehn, SA Marraco |
Frontiers in immunology | 2013 |
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Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?
M Hölzel, A Bovier, T Tüting |
Nature Reviews Cancer | 2013 |
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Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors
F Sandoval, M Terme, M Nizard, C Badoual, MF Bureau, L Freyburger, O Clement, E Marcheteau, A Gey, G Fraisse, C Bouguin, N Merillon, E Dransart, T Tran, F Quintin-Colonna, G Autret, M Thiebaud, M Suleman, S Riffault, TC Wu, O Launay, C Danel, J Taieb, J Richardson, L Zitvogel, WH Fridman, L Johannes, E Tartour |
Science Translational Medicine | 2013 |
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T cell vaccinology: Exploring the known unknowns
MA Burchill, BA Tamburini, ND Pennock, JT White, JS Kurche, RM Kedl |
Vaccine | 2013 |
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Bypassing T cell 'exhaustion'
JR Göthert |
Nature Immunology | 2013 |
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Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients
F Buchegger, SM Larson, JP Mach, Y Chalandon, PY Dietrich, A Cairoli, JO Prior, P Romero, DE Speiser |
Clinical & developmental immunology | 2013 |
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A patient-specific therapeutic approach for tumour cell population extinction and drug toxicity reduction using control systems-based dose-profile design
S Kapoor, VP Rallabandi, C Sakode, R Padhi, PK Roy |
Theoretical Biology and Medical Modelling | 2013 |
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Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
AL Doedens, AT Phan, MH Stradner, JK Fujimoto, JV Nguyen, E Yang, RS Johnson, AW Goldrath |
Nature Immunology | 2013 |
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Endogenous tumor-reactive CD8(+) T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth
X Liu, RM Gibbons, SM Harrington, CJ Krco, SN Markovic, ED Kwon, H Dong |
OncoImmunology | 2013 |
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Antibodies Targeting Human OX40 Expand Effector T Cells and Block Inducible and Natural Regulatory T Cell Function
KS Voo, L Bover, ML Harline, LT Vien, V Facchinetti, K Arima, LW Kwak, YJ Liu |
2013 | |
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Anti-leukemia T cells in AML: TNF-α + CD8 + T cells may escape detection and possibly reflect a stage of functional impairment
A Flörcken, A Lessen, TH Terwey, B Dörken, R Arnold, A Pezzutto, J Westermann |
Human Vaccines & Immunotherapeutics | 2013 |
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Cancer testis antigen and immunotherapy
DK Krishnadas, Bai, Lucas |
ImmunoTargets and Therapy | 2013 |
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Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab
Meyer C, Cagnon L, Costa-Nunes CM, Baumgaertner P, Montandon N, Leyvraz L, Michielin O, Romano E, Speiser DE |
Cancer Immunology, Immunotherapy | 2013 |
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The stoichiometric production of IL-2 and IFN-γ mRNA defines memory T cells that can self-renew after adoptive transfer in humans
A Wang, S Chandran, SA Shah, Y Chiu, BC Paria, T Aghamolla, MM Alvarez-Downing, CC Lee, S Singh, T Li, ME Dudley, NP Restifo, SA Rosenberg, US Kammula |
Science Translational Medicine | 2012 |
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Paths to stemness: building the ultimate antitumour T cell
L Gattinoni, CA Klebanoff, NP Restifo |
Nature Reviews Cancer | 2012 |
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Extended Co-Expression of Inhibitory Receptors by Human CD8 T-Cells Depending on Differentiation, Antigen-Specificity and Anatomical Localization
L Baitsch, A Legat, L Barba, SA Marraco, JP Rivals, P Baumgaertner, C Christiansen-Jucht, H Bouzourene, D Rimoldi, H Pircher, N Rufer, M Matter, O Michielin, DE Speiser |
PloS one | 2012 |
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Current translational and clinical practices in hematopoietic cell and gene therapy
DL Digiusto, HP Kiem |
Cytotherapy | 2012 |
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Adoptive immunotherapy for cancer: harnessing the T cell response
NP Restifo, ME Dudley, SA Rosenberg |
Nature Reviews Immunology | 2012 |
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Immune Microenvironment in Tumor Progression: Characteristics and Challenges for Therapy
V Chew, HC Toh, JP Abastado |
Journal of Oncology | 2012 |
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Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
TA Doering, A Crawford, JM Angelosanto, MA Paley, CG Ziegler, EJ Wherry |
Immunity | 2012 |
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Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
MA Swartz, AW Lund |
Nature Reviews Cancer | 2012 |
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Rescued Tolerant CD8 T Cells Are Preprogrammed to Reestablish the Tolerant State
A Schietinger, JJ Delrow, RS Basom, JN Blattman, PD Greenberg |
Science | 2012 |
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Cell-intrinsic abrogation of TGF-β signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer
CK Chou, A Schietinger, HD Liggitt, X Tan, S Funk, GJ Freeman, TL Ratliff, NM Greenberg, PD Greenberg |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
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Anti-tumor immunity: Myeloid leukocytes control the immune landscape
MR Rutkowski, TL Stephen, JR Conejo-Garcia |
Cellular Immunology | 2012 |
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PD-1 and BTLA and CD8+ T-cell “exhaustion” in cancer
C Haymaker, R Wu, C Bernatchez, L Radvanyi |
OncoImmunology | 2012 |
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Deconvolving heterogeneity in the CD8+ T-cell response to HIV :
WN Haining, RA Barnitz |
Current Opinion in HIV and AIDS | 2012 |
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A molecular profile of T-cell exhaustion in cancer
DE Speiser |
OncoImmunology | 2012 |
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PD-1 targeting in cancer immunotherapy
R Ferris |
Cancer | 2012 |
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Human melanoma-specific CD8(+) T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo.
Mahnke YD, Devevre E, Baumgaertner P, Matter M, Rufer N, Romero P, Speiser DE |
OncoImmunology | 2012 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Melanoma: oncogenic drivers and the immune system
Niki Karachaliou, Sara Pilotto, Cristina Teixidó, Santiago Viteri, María González-Cao, Aldo Riso, Daniela Morales-Espinosa, Miguel Angel Molina, Imane Chaib, Mariacarmela Santarpia, Eduardo Richardet, Emilio Bria, Rafael Rosell |
Annals of translational medicine |
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