Integral role of integrins in Th17 development
Derek A. Pociask, Jay K. Kolls
Derek A. Pociask, Jay K. Kolls
Published November 22, 2010
Citation Information: J Clin Invest. 2010;120(12):4185-4187. https://doi.org/10.1172/JCI45450.
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Integral role of integrins in Th17 development

Abstract

A lineage of CD4+ T cells known as Th17 cells, which are derived by exposure of naive CD4+ T cells to IL-6 and TGF-β, have been implicated in several autoimmune diseases. In this issue of the JCI, studies by Acharya et al. and Melton et al. show that TGF-β is activated at the DC/CD4+ T cell synapse by αv integrins and that this activation is required for Th17 differentiation and autoimmunity in the central nervous system. Thus, these studies offer a potential therapeutic target in fighting autoimmune diseases.

Authors

Derek A. Pociask, Jay K. Kolls

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Figure 1

Schematic representation of Th17 differentiation.

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Schematic representation of Th17 differentiation. Two studies in this is...
Two studies in this issue of the JCI (10, 11) demonstrate that TGF-β is activated at the DC/CD4+ T cell synapse by αv integrins and that this activation is required for Th17 differentiation in vitro. Moreover, mice lacking αv integrins on DCs fail to develop EAE, a disease mediated by Th17 cells.