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Citations to this article

NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
Jianhua Yu, … , Susheela Tridandapani, Michael A. Caligiuri
Jianhua Yu, … , Susheela Tridandapani, Michael A. Caligiuri
Published March 1, 2011
Citation Information: J Clin Invest. 2011;121(4):1456-1470. https://doi.org/10.1172/JCI43242.
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Research Article Hematology Article has an altmetric score of 7

NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human

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Abstract

IL-15 may have a role in the development of T cell large granular lymphocyte (T-LGL) or NKT leukemias. However, the mechanisms of action and the identity of the cell subset that undergoes leukemic transformation remain elusive. Here we show that in both mice and humans, NKp46 expression marks a minute population of WT NKT cells with higher activity and potency to become leukemic. Virtually 100% of T-LGL leukemias in IL-15 transgenic mice expressed NKp46, as did a majority of human T-LGL leukemias. The minute NKp46+ NKT population, but not the NKp46– NKT population, was selectively expanded by overexpression of endogenous IL-15. Importantly, IL-15 transgenic NKp46– NKT cells did not become NKp46+ in vivo, suggesting that NKp46+ T-LGL leukemia cells were the malignant counterpart of the minute WT NKp46+ NKT population. Mechanistically, NKp46+ NKT cells possessed higher responsiveness to IL-15 in vitro and in vivo compared with that of their NKp46– NKT counterparts. Furthermore, interruption of IL-15 signaling using a neutralizing antibody could prevent LGL leukemia in IL-15 transgenic mice. Collectively, our data demonstrate that NKp46 identifies a functionally distinct NKT subset in mice and humans that appears to be directly susceptible to leukemic transformation when IL-15 is overexpressed. Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia.

Authors

Jianhua Yu, Takeki Mitsui, Min Wei, Hsiaoyin Mao, Jonathan P. Butchar, Mithun Vinod Shah, Jianying Zhang, Anjali Mishra, Christopher Alvarez-Breckenridge, Xingluo Liu, Shujun Liu, Akihiko Yokohama, Rossana Trotta, Guido Marcucci, Don M. Benson Jr., Thomas P. Loughran Jr., Susheela Tridandapani, Michael A. Caligiuri

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Total citations by year

Year: 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Total
Citations: 2 5 1 3 4 4 2 4 1 6 3 5 2 42
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Citations to this article (42)

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ImmunoTargets and Therapy 2024
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Clinical Reviews in Allergy & Immunology 2024
Adipocyte CD1d Gene Transfer Induces T Cell Expansion and Adipocyte Inflammation in CD1d Knockout Mice
R Xiao, A Mansour, W Huang, Q Hassan, R Wilkins, S Komatineni, R Bates, S Ali, L Chrislip, N Queen, S Ma, J Yu, M Lordo, B Mundy-Bosse, M Caligiuri, L Cao
Journal of immunology (Baltimore, Md. : 1950) 2022
PDGF-D−PDGFRβ signaling enhances IL-15–mediated human natural killer cell survival
S Ma, T Tang, X Wu, A Mansour, T Lu, J Zhang, L Wang, M Caligiuri, J Yu
Proceedings of the National Academy of Sciences 2022
Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders
Hue SS, Ng SB, Wang S, Tan SY
Cancers 2022
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy.
Ma S, Caligiuri MA, Yu J
Trends in Immunology 2022
Cationic Polyethyleneimine (PEI)-Gold Nanocomposites Modulate Macrophage Activation and Reprogram Mouse Breast Triple-Negative MET-1 Tumor Immunological Microenvironment.
Mulens-Arias V, Nicolás-Boluda A, Carn F, Gazeau F
Pharmaceutics 2022
Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis
Somasundara AV, Moss MA, Feigman MJ, Chen C, Cyrill SL, Ciccone MF, Trousdell MC, Vollbrecht M, Li S, Kendall J, Beyaz S, Wilkinson JE, dos Santos CO
Cell Reports 2021
Translational Bioinformatics for Therapeutic Development
J Markowitz
2020
Single injection of IL-12 coacervate as an effective therapy against B16-F10 melanoma in mice
MP Hwang, RJ Fecek, T Qin, WJ Storkus, Y Wang
Journal of Controlled Release 2020
Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia
A Crinier, PY Dumas, B Escalière, C Piperoglou, L Gil, A Villacreces, F Vély, Z Ivanovic, P Milpied, É Narni-Mancinelli, É Vivier
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The Natural Cytotoxicity Receptors in Health and Disease
AD Barrow, CJ Martin, M Colonna
Frontiers in immunology 2019
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Molecular Therapy 2019
STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia
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S FauteuxDaniel, F Faure, M Marotel, C Geary, C Daussy, JC Sun, T Walzer
European Journal of Immunology 2019
Distinct human circulating NKp30 + FcεRIγ + CD8 + T cell population exhibiting high natural killer-like antitumor potential
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Dependence of innate lymphoid cell 1 development on NKp46
Y Wang, W Dong, Y Zhang, MA Caligiuri, J Yu, A Bhandoola
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EMBO Molecular Medicine 2018
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Complement factor P is a ligand for the natural killer cell–activating receptor NKp46
E Narni-Mancinelli, L Gauthier, M Baratin, S Guia, A Fenis, AE Deghmane, B Rossi, P Fourquet, B Escalière, YM Kerdiles, S Ugolini, MK Taha, E Vivier
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