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Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.

S Shimoda, … , T E Roche, M E Gershwin

S Shimoda, … , T E Roche, M E Gershwin

Published November 15, 1998
Citation Information: J Clin Invest. 1998;102(10):1831-1840. https://doi.org/10.1172/JCI4213.

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Citations to this article (204)

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Roles of cuproptosis-related gene DLAT in various cancers: a bioinformatic analysis and preliminary verification on pro-survival autophagy Yang Q, Zeng S, Liu W	PeerJ	2023
Role of autoantibodies in the clinical management of primary biliary cholangitis. Rigopoulou EI, Bogdanos DP	World Journal of Gastroenterology	2023
Distinct immune surveillance in primary biliary cholangitis and primary sclerosing cholangitis is linked with discrete cholangiocarcinoma risk. Nanjundappa RH, Christen U, Umeshappa CS	Hepatology Communications	2023
Sequence of events leading to primary biliary cholangitis. Lenci I, Carnì P, Milana M, Bicaj A, Signorello A, Baiocchi L	World Journal of Gastroenterology	2023
rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases. Hitomi Y, Ueno K, Aiba Y, Nishida N, Kawai Y, Kawashima M, Khor SS, Takada S, Iwabuchi C, Nagasaki M, Tokunaga K, Nakamura M	Human Genetics	2023
Linking Human Betaretrovirus with Autoimmunity and Liver Disease in Patients with Primary Biliary Cholangitis. Syed H, Penner T, Mason AL	Viruses	2022
Mitochondrial Proteins as Source of Cancer Neoantigens. Prota G, Lechuga-Vieco AV, De Libero G	International journal of molecular sciences	2022
rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms. Hitomi Y, Aiba Y, Ueno K, Nishida N, Kawai Y, Kawashima M, Tsuiji M, Iwabuchi C, Takada S, Miyake N, Nagasaki M, Tokunaga K, Nakamura M	Human genomics	2022
The latest research trends in primary biliary cholangitis: a bibliometric analysis. Zhao Y, Yin Z, Du H, Huang K, Zhang F, Chen H	Clinical and Experimental Medicine	2022
Cholestatic liver disease: Practice guidelines from the Saudi Association for the Study of Liver diseases and Transplantation Mawardi M, Alalwan A, Fallatah H, Abaalkhail F, Hasosah M, Shagrani M, Alghamdi MY, Alghamdi AS	Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association	2021
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rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis Y Hitomi, Y Aiba, Y Kawai, K Kojima, K Ueno, N Nishida, M Kawashima, O Gervais, SS Khor, M Nagasaki, K Tokunaga, M Nakamura, M Tsuiji	Scientific Reports	2021
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Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis U Wasik, A Kempinska-Podhorodecka, DP Bogdanos, P Milkiewicz, M Milkiewicz	Molecular Medicine	2020
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TCR β repertoire of memory T cell reveals potential role for Escherichia coli in the pathogenesis of primary biliary cholangitis X Hou, Y Yang, J Chen, H Jia, P Zeng, L Lv, Y Lu, X Liu, H Diao	Liver International	2019
Immunological abnormalities in patients with primary biliary cholangitis WT Ma, DK Chen	Clinical Science	2019
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miR-425 regulates inflammatory cytokine production in CD4 + T cells via N-Ras upregulation in primary biliary cholangitis R Nakagawa, R Muroyama, C Saeki, K Goto, Y Kaise, K Koike, M Nakano, Y Matsubara, K Takano, S Ito, M Saruta, N Kato, M Zeniya	Journal of Hepatology	2017
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Primary biliary cirrhosis: From bench to bedside E Kouroumalis	World journal of gastrointestinal pharmacology and therapeutics	2015
Natural killer cells regulate T cell immune responses in primary biliary cirrhosis: Switch mechanisms in PBC S Shimoda, S Hisamoto, K Harada, S Iwasaka, Y Chong, M Nakamura, Y Bekki, T Yoshizumi, K Shirabe, T Ikegami, Y Maehara, XS He, ME Gershwin, K Akashi	Hepatology	2015
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A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis M Sasaki, M Yoshimura-Miyakoshi, Y Sato, Y Nakanuma	Journal of Gastroenterology	2015
DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis A Lleo, W Zhang, M Zhao, Y Tan, F Bernuzzi, B Zhu, Q Liu, Q Tan, F Malinverno, L Valenti, T Jiang, L Tan, W Liao, R Coppel, P Invernizzi, Q Lu, DH Adams, ME Gershwin	Clinical Epigenetics	2015
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The immunogenetics of primary biliary cirrhosis: A comprehensive review GJ Webb, KA Siminovitch, GM Hirschfield	Journal of Autoimmunity	2015
Proposed therapies in primary biliary cholangitis A Floreani, Y Sun, ZS Zou, B Li, N Cazzagon, CL Bowlus, ME Gershwin	Expert Review of Gastroenterology & Hepatology	2015
Role of Novel Retroviruses in Chronic Liver Disease: Assessing the Link of Human Betaretrovirus with Primary Biliary Cirrhosis D Sharon, AL Mason	Current Infectious Disease Reports	2015
Functional Role of Cellular Senescence in Biliary Injury L Meng, M Quezada, P Levine, Y Han, K McDaniel, T Zhou, E Lin, S Glaser, F Meng, H Francis, G Alpini	The American Journal of Pathology	2015
Making Sense of Autoantibodies in Cholestatic Liver Diseases S Marzorati, P Invernizzi, A Lleo	Clinics in Liver Disease	2015
The management of autoimmunity in patients with cholestatic liver diseases AH Ali, EJ Carey, KD Lindor	Expert Review of Gastroenterology & Hepatology	2015
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Therapeutic effect of CTLA4-Ig on a murine model of primary biliary cirrhosis A Dhirapong, GX Yang, S Nadler, W Zhang, K Tsuneyama, P Leung, S Knechtle, AA Ansari, RL Coppel, FT Liu, XS He, ME Gershwin	Hepatology	2013
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The Genetics of Complex Cholestatic Disorders GM Hirschfield, RW Chapman, TH Karlsen, F Lammert, KN Lazaridis, AL Mason	Gastroenterology	2013
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Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy M Sasaki, Y Nakanuma	International Journal of Hepatology	2012
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A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis M Sasaki, M Miyakoshi, Y Sato, Y Nakanuma	Liver International	2011
Autoimmunity and Environment: Am I at risk? D Smyk, EI Rigopoulou, H Baum, AK Burroughs, D Vergani, DP Bogdanos	Clinical Reviews in Allergy & Immunology	2011
The Interaction Between Toll Like Receptors and Natural Killer Cells in the Destruction of Bile Ducts in Primary Biliary Cirrhosis S Shimoda, K Harada, H Niiro, K Shirabe, A Taketomi, Y Maehara, K Tsuneyama, Y Nakanuma, P Leung, AA Ansari, ME Gershwin, K Akashi	Hepatology	2011
Primary Biliary Cirrhosis Associated with Systemic Sclerosis: Diagnostic and Clinical Challenges C Rigamonti, DP Bogdanos, MG Mytilinaiou, DS Smyk, EI Rigopoulou, AK Burroughs	International Journal of Rheumatology	2011
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Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis M Sasaki, Y Nakanuma	Hepatitis Research and Treatment	2010
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Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis M Sasaki, M Miyakoshi, Y Sato, Y Nakanuma	Journal of Hepatology	2010
Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients S Joshita, T Umemura, K Yoshizawa, Y Katsuyama, E Tanaka, M Nakamura, H Ishibashi, M Ota	Journal of Hepatology	2010
Serum BAFF and APRIL levels in patients with PBC K Migita, B Ilyassova, EF Kovzel, A Nersesov, S Abiru, Y Maeda, A Komori, M Ito, K Yano, H Yatsuhashi, S Shimoda, H Ishibashi, M Nakamura	Clinical Immunology	2010
Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis M Sasaki, M Miyakoshi, Y Sato, Y Nakanuma	Laboratory Investigation	2010
Molecular Pathology of Liver Diseases SP Monga		2010
Primary biliary cirrhosis S Hohenester, RP Oude-Elferink, U Beuers	Seminars in Immunopathology	2009
Experimental evidence on the immunopathogenesis of primary biliary cirrhosis C Selmi, F Meda, A Kasangian, P Invernizzi, Z Tian, Z Lian, M Podda, ME Gershwin	Cellular and Molecular Immunology	2009
CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis S Shimoda, K Harada, H Niiro, A Taketomi, Y Maehara, K Tsuneyama, K Kikuchi, Y Nakanuma, IR Mackay, ME Gershwin, K Akashi	Hepatology	2009
Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization K Wakabayashi, K Yoshida, PS Leung, Y Moritoki, GX Yang, K Tsuneyama, ZX Lian, T Hibi, AA Ansari, LS Wicker, WM Ridgway, RL Coppel, IR Mackay, ME Gershwin	Clinical & Experimental Immunology	2009
Etiopathogenesis of primary biliary cirrhosis A Lleo, P Invernizzi, IR Mackay, H Prince, RQ Zhong, ME Gershwin	World journal of gastroenterology : WJG	2008
The unfinished business of primary biliary cirrhosis C Selmi, M Zuin, ME Gershwin	Journal of Hepatology	2008
Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: An immunohistochemical study M Sasaki, H Ikeda, Y Nakanuma	Journal of Autoimmunity	2008
Animal models of primary biliary cirrhosis YH Chuang, WM Ridgway, Y Ueno, ME Gershwin	Clinics in Liver Disease	2008
Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence M Sasaki, H Ikeda, J Yamaguchi, S Nakada, Y Nakanuma	Hepatology	2008
Pathogenesis of Primary Biliary Cirrhosis DE Jones	Clinics in Liver Disease	2008
Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells S Shimoda, K Harada, H Niiro, T Yoshizumi, Y Soejima, A Taketomi, Y Maehara, K Tsuneyama, M Nakamura, A Komori, K Migita, Y Nakanuma, H Ishibashi, C Selmi, ME Gershwin	Hepatology	2008
Environmental factors and the induction of autoimmunity in primary biliary cirrhosis C Selmi, A Diana, CA Cocchi, M Zuin, ME Gershwin	Expert Review of Clinical Immunology	2008
Bacteria and Primary Biliary Cirrhosis DP Bogdanos, D Vergani	Clinical Reviews in Allergy & Immunology	2008
Etiopathogenesis of primary biliary cirrhosis A Lleo, P Invernizzi, IR Mackay, H Prince, RQ Zhong, ME Gershwin	World journal of gastroenterology : WJG	2008
Pathogenesis and Clinical Practice in Gastroenterology I Ferkolj, A Gangl, PR Galle, B Vucelic		2008
Pathogenesis of primary biliary cirrhosis DE Jones	Gut	2007
Primary biliary cirrhosis: what we know and what we want to know about human PBC and spontaneous PBC mouse models Y Ueno, Y Moritoki, T Shimosegawa, ME Gershwin	Journal of Gastroenterology	2007
The X and why of xenobiotics in primary biliary cirrhosis R Rieger, ME Gershwin	Journal of Autoimmunity	2007
Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance M Sasaki, H Ikeda, Y Nakanuma	Progress in Histochemistry and Cytochemistry	2007
Activated T cell subsets in human type 1 diabetes: evidence for expansion of the DR+ CD30+ subpopulation in new-onset disease C Baker, L Chang, KA Elsegood, AJ Bishop, DH Gannon, P Narendran, NJ Leech, CM Dayan	Clinical & Experimental Immunology	2007
The causes of primary biliary cirrhosis: Convenient and inconvenient truths ME Gershwin, IR Mackay	Hepatology	2007
How, why, and when does primary biliary cirrhosis recur after liver transplantation? R Williams, ME Gershwin	Liver Transplantation	2007
B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage AL Foreman, JV de Water, ML Gougeon, ME Gershwin	Autoimmunity Reviews	2007
Murine models of primary biliary cirrhosis: Comparisons and contrasts S Oertelt, WM Ridgway, AA Ansari, RL Coppel, ME Gershwin	Hepatology Research	2007
Autoimmune diseases of the liver, autoimmune hepatitis and primary biliary cirrhosis: Unfinished business IR Mackay	Hepatology Research	2007
AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers Y Moritoki, ZX Lian, H Wulff, GX Yang, YH Chuang, RY Lan, Y Ueno, AA Ansari, RL Coppel, IR Mackay, ME Gershwin	Hepatology	2007
Peripheral Tolerance and the Qualitative Characteristics of Autoreactive T Cell Clones in Primary Biliary Cirrhosis A Kawano, S Shimoda, T Kamihira, F Ishikawa, H Niiro, Y Soejima, A Taketomi, Y Maehara, M Nakamura, A Komori, K Migita, H Ishibashi, M Azuma, ME Gershwin, M Harada	Journal of immunology (Baltimore, Md. : 1950)	2007
Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis M Sasaki, H Ikeda, Y Sato, Y Nakanuma	The American Journal of Pathology	2006
Transgenic mice aberrantly expressing pyruvate dehydrogenase complex E2 component on biliary epithelial cells do not show primary biliary cirrhosis K Inamura, H Tsuji, Y Nakamoto, M Suzuki, S Kaneko	Clinical & Experimental Immunology	2006
T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis J Allina, B Hu, DM Sullivan, MI Fiel, SN Thung, SF Bronk, RC Huebert, J van de Water, NF LaRusso, ME Gershwin, GJ Gores, JA Odin	Journal of Autoimmunity	2006
Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis M Sasaki, H Ikeda, S Sawada, Y Sato, Y Nakanuma	Journal of clinical pathology	2006
Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis M Sasaki, H Ikeda, H Kataoka, Y Nakanuma	Virchows Archiv	2006
Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis M Nakamura, Y Takii, M Ito, A Komori, T Yokoyama, Y Shimizu-Yoshida, M Koyabu, M Matsuyama, T Mori, T Kamihira, M Daikoku, K Migita, H Yatsuhashi, N Nozaki, S Shimoda, H Ishibashi	Journal of Autoimmunity	2006
Polyclonal T-Cell Responses to Cytochrome P450IID6 Are Associated With Disease Activity in Autoimmune Hepatitis Type 2 Y Ma, DP Bogdanos, MJ Hussain, J Underhill, S Bansal, MS Longhi, P Cheeseman, G Mieli–Vergani, D Vergani	Gastroenterology	2006
New insights to the immunopathology and autoimmune responses in primary biliary cirrhosis XS He, AA Ansari, WM Ridgway, RL Coppel, ME Gershwin	Cellular Immunology	2006
The Autoimmune Diseases I Kang, J Craft	The Autoimmune Diseases	2006
PDC-E3BP is not a dominant T-cell autoantigen in primary biliary cirrhosis A McHugh, AJ Robe, JM Palmer, DE Jones	Liver International	2006
Pathogenesis of primary biliary cirrhosis: a unifying model E Kouroumalis, G Notas	World journal of gastroenterology : WJG	2006
Lack of association between appendectomy and primary biliary cirrhosis EI Rigopoulou, SP Georgiadou, S Barbanis, GN Dalekos	Scandinavian Journal of Gastroenterology	2006
Pathogenesis of primary biliary cirrhosis: A unifying model E Kouroumalis	World journal of gastroenterology : WJG	2006
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss M Sasaki, H Ikeda, H Haga, T Manabe, Y Nakanuma	The Journal of Pathology	2005
Mitochondrial Antigens as Targets of Cellular and Humoral Auto-Immunity in Primary Biliary Cirrhosis Y Ichiki, C Selmi, S Shimoda, H Ishibashi, SC Gordon, ME Gershwin	Clinical Reviews in Allergy & Immunology	2005
The Enigma of Primary Biliary Cirrhosis C Selmi, Y Ichiki, P Invernizzi, M Podda, ME Gershwin	Clinical Reviews in Allergy & Immunology	2005
Primary Biliary Cirrhosis MM Kaplan, ME Gershwin	New England Journal of Medicine	2005
Genes and (auto)immunity in primary biliary cirrhosis C Selmi, P Invernizzi, M Zuin, M Podda, MF Seldin, ME Gershwin	Genes and Immunity	2005
Solving the primary biliary cirrhosis puzzle: The emerging image of immunopathology in primary biliary cirrhosis RY Lan, P Leung, AA Ansari, RL Coppel, ME Gershwin	Clinical and Applied Immunology Reviews	2005
Mucosal Immunology WR Brown	Mucosal Immunology	2005
Biliary epithelial cells regulate autoreactive T cells: implications for biliary-specific diseases T Kamihira, S Shimoda, M Nakamura, T Yokoyama, Y Takii, A Kawano, M Handa, H Ishibashi, ME Gershwin, M Harada	Hepatology	2005
Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic DP Bogdanos, H Baum, M Okamoto, P Montalto, UC Sharma, EI Rigopoulou, J Vlachogiannakos, Y Ma, AK Burroughs, D Vergani	Hepatology	2005
Primary Biliary Cirrhosis: Solving the Enigma A Giorgini, C Selmi, P Invernizzi, M Podda, M Zuin, M Gershwin	Annals of the New York Academy of Sciences	2005
Autoimmune Liver Disease , U Leuschner, AW Lohse, MP Manns		2005
Current concepts in the pathogenesis of primary biliary cirrhosis P Charatcharoenwitthaya, KD Lindor	ANN HEPATOL	2005
Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis TK Mao, PA Davis, JA Odin, RL Coppel, ME Gershwin	Hepatology	2004
Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria–type cells X Feng, T Chuhjo, C Sugimori, T Kotani, X Lu, A Takami, H Takamatsu, H Yamazaki, S Nakao	Blood	2004
Retrovirus infection as a trigger for primary biliary cirrhosis? R Poupon, RE Poupon	The Lancet	2004
Disease-specific cross-reactivity between mimicking peptides of heat shock protein of mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis DP Bogdanos, A Pares, H Baum, L Caballeria, EI Rigopoulou, Y Ma, AK Burroughs, J Rodes, D Vergani	Journal of Autoimmunity	2004
Is primary biliary cirrhosis a model autoimmune disease? Y Ichiki, S Shimoda, H Ishibashi, ME Gershwin	Autoimmunity Reviews	2004
Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis S Matsumura, JV de Water, P Leung, JA Odin, K Yamamoto, GJ Gores, K Mostov, AA Ansari, RL Coppel, Y Shiratori, ME Gershwin	Hepatology	2004
Novosphingobium Aromaticivorans: A Potential Initiator of Primary Biliary Cirrhosis MM Kaplan	The American Journal of Gastroenterology	2004
Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis DP Bogdanos, H Baum, A Grasso, M Okamoto, P Butler, Y Ma, E Rigopoulou, P Montalto, ET Davies, AK Burroughs, D Vergani	Journal of Hepatology	2004
Infection and Autoimmunity C Dugué, Y Renaudineau, P Youinou	Infection and Autoimmunity	2004
Primary biliary cirrhosis and autoimmune cholangiopathy JM Vierling	Clinics in Liver Disease	2004
Primary biliary cirrhosis: for want of an X chromosome? MM Kaplan, DW Bianchi	The Lancet	2004
Unusual suspects in primary biliary cirrhosis D Vergani, DP Bogdanos, H Baum	Hepatology	2004
Autoimmunity and environmental factors in the pathogenesis of primary biliary cirrhosis H Kita, XS He, ME Gershwin	Annals of Medicine	2004
Xenobiotic-Induced Loss of Tolerance in Rabbits to the Mitochondrial Autoantigen of Primary Biliary Cirrhosis Is Reversible K Amano, PS Leung, Q Xu, J Marik, C Quan, MJ Kurth, MH Nantz, AA Ansari, KS Lam, M Zeniya, RL Coppel, ME Gershwin	Journal of immunology (Baltimore, Md. : 1950)	2004
Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies PS Leung, C Quan, O Park, JV de Water, MJ Kurth, MH Nantz, AA Ansari, RL Coppel, KS Lam, ME Gershwin	Journal of immunology (Baltimore, Md. : 1950)	2003
Promiscuous T cells selected by Escherichia coli: OGDC-E2 in primary biliary cirrhosis H Tanimoto, S Shimoda, M Nakamura, H Ishibashi, A Kawano, T Kamihira, S Matsushita, ME Gershwin, M Harada	Journal of Autoimmunity	2003
Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis S Shimoda, M Nakamura, H Ishibashi, A Kawano, T Kamihira, N Sakamoto, S Matsushita, A Tanaka, HJ Worman, ME Gershwin, M Harada	Gastroenterology	2003
T cell immunity and primary biliary cirrhosis H Ishibashi, M Nakamura, S Shimoda, ME Gershwin	Autoimmunity Reviews	2003
Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis T Kamihira, S Shimoda, K Harada, A Kawano, M Handa, E Baba, K Tsuneyama, M Nakamura, H Ishibashi, Y Nakanuma, ME Gershwin, M Harada	Gastroenterology	2003
Pathogenesis of primary biliary cirrhosis DE Jones	Journal of Hepatology	2003
Quantitative and functional analysis of PDC-E2 specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis Hiroto Kita, Shuji Matsumura, Xiao-Song He, Aftab A. Ansari, Zhe-Xiong Lian, Judy Van de Water, Ross L. Coppel, Marshall Kaplan, M. Eric Gershwin	Journal of Clinical Investigation	2002
The immunology of primary biliary cirrhosis: the end of the beginning? JM Palmer, JA Kirby, DE Jones	Clinical & Experimental Immunology	2002
Hepatoimmunology: A perspective IR Mackay	Immunology and Cell Biology	2002
Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells H Kita, ZX Lian, JV de Water, XS He, S Matsumura, M Kaplan, V Luketic, RL Coppel, AA Ansari, ME Gershwin	Journal of Experimental Medicine	2002
Primary biliary cirrhosis: seeking the silent partner of autoimmunity I Sutton, J Neuberger	Gut	2002
Anti-mitochondrial autoantibodies MJ Fritzler, MP Manns	Clinical and Applied Immunology Reviews	2002
Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics SA Long, JV de Water, ME Gershwin	Autoimmunity Reviews	2002
Pyruvate dehydrogenase specific T cells in primary biliary cirrhosis show restricted antigen recognition sites S Pingel, M Arenz, KH Buschenfelde, HF Lohr	Liver International	2002
Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer H Kita, OV Naidenko, M Kronenberg, AA Ansari, P Rogers, XS He, F Koning, T Mikayama, JV de Water, RL Coppel, M Kaplan, ME Gershwin	Gastroenterology	2002
The SJL/J mouse is not a model for PBC M Sasaki, SA Long, JV de Water, XS He, L Shultz, RL Coppel, A Ansari, Y Nakanuma, ME Gershwin	Hepatology	2002
Up-regulation of CD11a (LFA-1) expression on peripheral CD4+ T cells in primary biliary cirrhosis Masaaki Shiina, Koju Kobayashi, Yutaka Mano, Yoshiyuki Ueno, Motoyasu Ishii, Tooru Shimosegawa	Digestive Diseases and Sciences	2002
Cholangiocytes and primary biliary cirrhosis-prediction and predication M. Eric Gershwin, Judy Van de Walter	Journal of Clinical Investigation	2001
Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis SA Long, C Quan, JV de Water, MH Nantz, MJ Kurth, D Barsky, ME Colvin, KS Lam, RL Coppel, A Ansari, ME Gershwin	Journal of immunology (Baltimore, Md. : 1950)	2001
Immunopathogenesis of cholestatic autoimmune liver diseases J Medina, EA Jones, C Garcia-Monzon, R Moreno-Otero	European Journal of Clinical Investigation	2001
Xenobiotic Considerations for the Development of Autoimmune Liver Diseases: Bad Genes and Bad Luck XS He, AA Ansari, ME Gershwin	Reviews on Environmental Health	2001
T cell repertoire in primary biliary cirrhosis: a common T cell clone and repertoire change after treatment R Okamoto, K Yamamoto, K Yabushita, N Okano, N Shimada, S Matsumura, M Mizuno, T Higashi, T Tsuji	Journal of Clinical Immunology	2001
Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosis M J Mayo, P E Lipsky, S N Miller, P Stastny, B Combes	Digestive Diseases and Sciences	2001
Virus, liver and autoimmunity DP Bogdanos, G Mieli-Vergani, D Vergani	Digestive and Liver Disease	2000
The pyruvate dehydrogenase complex as a target autoantigen in primary biliary cirrhosis A Nishio, R Coppel, H Ishibashi, ME Gershwin	Best Practice & Research Clinical Gastroenterology	2000
Destruction of bile ducts in primary biliary cirrhosis Y Nakanuma, K Tsuneyama, M Sasaki, K Harada	Best Practice & Research Clinical Gastroenterology	2000
Autoimmunity and primary biliary cirrhosis IR Mackay	Best Practice & Research Clinical Gastroenterology	2000
Nucleotide variations amongst V(H)Genes of AMA-producing B cell clones in primary biliary cirrhosis N Fukushima, H Ikematsu, M Nakamura, M Matsui, S Shimoda, K Hayashida, Y Niho, K Koike, ME Gershwin, H Ishibashi	Journal of Autoimmunity	2000
Fine Specificity of T Cells Reactive to Human PDC-E2 163-176 Peptide, the Immunodominant Autoantigen in Primary Biliary Cirrhosis: Implications for Molecular Mimicry and Cross-Recognition Among Mitochondrial Autoantigens H Shigematsu	Hepatology	2000
Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis S Shimoda, M Nakamura, H Shigematsu, H Tanimoto, T Gushima, ME Gershwin, H Ishibashi	Hepatology	2000
Immunology and Liver MP Manns, G Paumgartner, U Leuschner		2000
Primary biliary cirrhosis Y Bar-Dayan, ME Gershwin, Y Levi, H Amital, Y Shoenfeld	Immunologic Research	1998
Immune disorders of the liver and bile duct H Kita, IR Mackay, JV de Water, ME Gershwin	Gastroenterology Clinics of North America	1992

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