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Davide Corti, … , Kanta Subbarao, Antonio Lanzavecchia
Published April 12, 2010
Citation Information: J Clin Invest. 2010;120(5):1663-1673. https://doi.org/10.1172/JCI41902.
Citation Information: J Clin Invest. 2010;120(5):1663-1673. https://doi.org/10.1172/JCI41902.
Abstract
The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1–H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic antibodies capable of neutralizing multiple influenza virus subtypes have been recently isolated from phage display libraries, it is not known whether such antibodies are produced in the course of an immune response to influenza virus infection or vaccine. Here we report that, following vaccination with seasonal influenza vaccine containing H1 and H3 influenza virus subtypes, some individuals produce antibodies that cross-react with H5 HA. By immortalizing IgG-expressing B cells from 4 individuals, we isolated 20 heterosubtypic mAbs that bound and neutralized viruses belonging to several HA subtypes (H1, H2, H5, H6, and H9), including the pandemic A/California/07/09 H1N1 isolate. The mAbs used different VH genes and carried a high frequency of somatic mutations. With the exception of a mAb that bound to the HA globular head, all heterosubtypic mAbs bound to acid-sensitive epitopes in the HA stem region. Four mAbs were evaluated in vivo and protected mice from challenge with influenza viruses representative of different subtypes. These findings reveal that seasonal influenza vaccination can induce polyclonal heterosubtypic neutralizing antibodies that cross-react with the swine-origin pandemic H1N1 influenza virus and with the highly pathogenic H5N1 virus.
Authors
Davide Corti, Amorsolo L. Suguitan Jr., Debora Pinna, Chiara Silacci, Blanca M. Fernandez-Rodriguez, Fabrizia Vanzetta, Celia Santos, Catherine J. Luke, Fernando J. Torres-Velez, Nigel J. Temperton, Robin A. Weiss, Federica Sallusto, Kanta Subbarao, Antonio Lanzavecchia
Total citations by year
Citation information
Citations to this article (283)
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H5N1 influenza vaccine induces a less robust neutralizing antibody response than seasonal trivalent and H7N9 influenza vaccines
SS Wong, J DeBeauchamp, M Zanin, Y Sun, L Tang, R Webby |
npj Vaccines | 2017 |
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A perspective on the structural and functional constraints for immune evasion: Insights from the influenza virus
NC Wu, IA Wilson |
Journal of Molecular Biology | 2017 |
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Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
IS Nandin, C Fong, C Deantonio, JA Torreno-Pina, S Pecetta, P Maldonado, F Gasparrini, J Ordovas-Montanes, SW Kazer, S Kjaer, DW Borley, U Nair, JA Coleman, D Lingwood, AK Shalek, E Meffre, P Poignard, DR Burton, FD Batista |
Journal of Experimental Medicine | 2017 |
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Protein and modified vaccinia virus Ankara-based influenza virus nucleoprotein vaccines are differentially immunogenic in BALB/c mice: Immunogenicity of influenza virus nucleoprotein vaccines
AF Altenburg, SE Magnusson, F Bosman, L Stertman, RD de Vries, GF Rimmelzwaan |
Clinical & Experimental Immunology | 2017 |
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Serosurveillance for pandemic influenza A (H1N1) 2009 virus infection in domestic elephants, Thailand
W Paungpin, W Wiriyarat, K Chaichoun, E Tiyanun, N Sangkachai, D Changsom, K Poltep, P Ratanakorn, P Puthavathana, F Krammer |
PloS one | 2017 |
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Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain
CS Anderson, S Ortega, FA Chaves, AM Clark, H Yang, DJ Topham, ML DeDiego |
Scientific Reports | 2017 |
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In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice
TC Sutton, EW Lamirande, KW Bock, IN Moore, W Koudstaal, M Rehman, GJ Weverling, J Goudsmit, K Subbarao, A García-Sastre |
Journal of virology | 2017 |
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Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants
TM Wong, JD Allen, AG Bebin-Blackwell, DM Carter, T Alefantis, J DiNapoli, H Kleanthous, TM Ross, S Schultz-Cherry |
Journal of virology | 2017 |
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Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
TC Sutton, S Chakraborty, VV Mallajosyula, EW Lamirande, K Ganti, KW Bock, IN Moore, R Varadarajan, K Subbarao |
npj Vaccines | 2017 |
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Is It Possible to Develop a “Universal” Influenza Virus Vaccine?: Immunogenetic Considerations Underlying B-Cell Biology in the Development of a Pan-Subtype Influenza A Vaccine Targeting the Hemagglutinin Stem
SF Andrews, BS Graham, JR Mascola, AB McDermott |
Cold Spring Harbor perspectives in biology | 2017 |
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Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9
C Chen, L Liu, Y Xiao, S Cui, J Wang, Q Jin, RM Sandri-Goldin |
Journal of virology | 2017 |
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Assessment of the influenza vaccine (VAXIGRIP) in triggering a humoural immune response
WH Mahallawi |
Journal of Taibah University Medical Sciences | 2017 |
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Tackling influenza with broadly neutralizing antibodies
Corti D, Cameroni E, Guarino B, Kallewaard NL, Zhu Q, Lanzavecchia A |
Current Opinion in Virology | 2017 |
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Harnessing Local Immunity for an Effective Universal Swine Influenza Vaccine.
Tchilian E, Holzer B |
Viruses | 2017 |
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Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA |
Cell Reports | 2017 |
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Anti-influenza antibody breadth necessitates Fc-receptor engagement to protect in vivo
David DiLillo, Peter Palese, Patrick Wilson, Jeffrey Ravetch |
Journal of Clinical Investigation | 2016 |
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Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8 + T Cell Activation In Vitro but Not in C57BL/6 Mice
AF Altenburg, CE van de Sandt, SE van Trierum, HL de Gruyter, PR van Run, RA Fouchier, K Roose, X Saelens, A Volz, G Sutter, RD de Vries, GF Rimmelzwaan, S Schultz-Cherry |
Journal of virology | 2016 |
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Statistical inference of a convergent antibody repertoire response to influenza vaccine
NB Strauli, RD Hernandez |
Genome Medicine | 2016 |
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In vitro reconstitution of B cell receptor–antigen interactions to evaluate potential vaccine candidates
GC Weaver, RF Villar, M Kanekiyo, GJ Nabel, JR Mascola, D Lingwood |
Nature Protocols | 2016 |
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Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic
GS Freidl, HJ Ham, MF Boni, E Bruin, MP Koopmans |
Scientific Reports | 2016 |
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Implications of broadly neutralizing antibodies in the development of a universal influenza vaccine
A Cho, J Wrammert |
Current Opinion in Virology | 2016 |
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Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
R Rappuoli, MJ Bottomley, U DOro, O Finco, ED Gregorio |
Journal of Experimental Medicine | 2016 |
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Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
KE Neu, CJ Dunand, PC Wilson |
Current Opinion in Immunology | 2016 |
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A novel antibody discovery platform identifies anti-influenza A broadly neutralizing antibodies from human memory B cells
X Xiao, Y Chen, R Varkey, N Kallewaard, AC Koksal, Q Zhu, H Wu, PS Chowdhury, WF Dall'Acqua |
mAbs | 2016 |
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Mathematical Model Reveals the Role of Memory CD8 T Cell Populations in Recall Responses to Influenza
VI Zarnitsyna, A Handel, SR McMaster, SL Hayward, JE Kohlmeier, R Antia |
Frontiers in immunology | 2016 |
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Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
NL Kallewaard, D Corti, PJ Collins, U Neu, JM McAuliffe, E Benjamin, L Wachter-Rosati, FJ Palmer-Hill, AQ Yuan, PA Walker, MK Vorlaender, S Bianchi, B Guarino, A De Marco, F Vanzetta, G Agatic, M Foglierini, D Pinna, B Fernandez-Rodriguez, A Fruehwirth, C Silacci, RW Ogrodowicz, SR Martin, F Sallusto, JA Suzich, A Lanzavecchia, Q Zhu, SJ Gamblin, JJ Skehel |
Cell | 2016 |
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HIV-dependent depletion of influenza-specific memory B cells impacts B cell responsiveness to seasonal influenza immunisation
AK Wheatley, AB Kristensen, WN Lay, SJ Kent |
Scientific Reports | 2016 |
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A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve
Y Fu, Z Zhang, J Sheehan, Y Avnir, C Ridenour, T Sachnik, J Sun, MJ Hossain, LM Chen, Q Zhu, RO Donis, WA Marasco |
Nature Communications | 2016 |
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Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody
N Chai, LR Swem, M Reichelt, H Chen-Harris, E Luis, S Park, A Fouts, P Lupardus, TD Wu, O Li, J McBride, M Lawrence, M Xu, MW Tan, P Palese |
PLoS pathogens | 2016 |
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Multi-epitope Models Explain How Pre-existing Antibodies Affect the Generation of Broadly Protective Responses to Influenza
VI Zarnitsyna, J Lavine, A Ellebedy, R Ahmed, R Antia, AS Lauring |
PLoS pathogens | 2016 |
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Association between Hemagglutinin Stem-Reactive Antibodies and Influenza A/H1N1 Virus Infection during the 2009 Pandemic
LN Hoa, LQ Mai, JE Bryant, PQ Thai, NL Hang, NT Yen, TN Duong, DD Thoang, P Horby, HF Werheim, A Fox, S Schultz-Cherry |
Journal of virology | 2016 |
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Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus
M Klausberger, R Tscheliessnig, S Neff, R Nachbagauer, TJ Wohlbold, M Wilde, D Palmberger, F Krammer, A Jungbauer, R Grabherr, SJ Turner |
PloS one | 2016 |
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Weighing serological evidence of human exposure to animal influenza viruses − a literature review
RS Sikkema, GS Freidl, E Bruin, M Koopmans |
Euro surveillance : bulletin europeen sur les maladies transmissibles = European communicable disease bulletin | 2016 |
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Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning
T Gaiotto, SE Hufton, L Du |
PloS one | 2016 |
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Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins
H Marjuki, VP Mishin, N Chai, MW Tan, EM Newton, J Tegeris, K Erlandson, M Willis, J Jones, T Davis, J Stevens, LV Gubareva, A García-Sastre |
Journal of virology | 2016 |
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Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination
SM Tete, F Krammer, S Lartey, G Bredholt, J Wood, S Skrede, RJ Cox |
npj Vaccines | 2016 |
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Antiviral Vaccines: Challenges and Advances
Ellebedy AH, Ahmed R |
The Vaccine Book | 2016 |
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Pre-existing human antibodies neutralize the novel influenza H7N9 strain
Carole Henry Dunand, Paul Leon, Kaval Kaur, Gene Tan, Nai-Ying Zheng, Sarah Andrews, Min Huang, Xinyan Qu, Yunping Huang, Marlene Salgado-Ferrer, Irvin Ho, William Taylor, Rong Hai, Jens Wrammert, Rafi Ahmed, Adolfo Garcia-Sastre, Peter Palese, Florian Krammer, Patrick C. Wilson |
Journal of Clinical Investigation | 2015 |
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Focused Antibody Response to Influenza linked to
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Kuan-Ying Huang, Pramila Rijal, Lisa Schimanski, Tim Powell, Tzou-Yien Lin, John McCauley, Rodney Daniels, Alain Townsend |
Journal of Clinical Investigation | 2015 |
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Restricted, canonical, stereotyped and convergent immunoglobulin responses
CJ Dunand, PC Wilson |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2015 |
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Immune history profoundly affects broadly protective B cell responses to influenza
SF Andrews, Y Huang, K Kaur, LI Popova, IY Ho, NT Pauli, CJ Dunand, WM Taylor, S Lim, M Huang, X Qu, JH Lee, M Salgado-Ferrer, F Krammer, P Palese, J Wrammert, R Ahmed, PC Wilson |
Science Translational Medicine | 2015 |
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Advances in the development of influenza virus vaccines
F Krammer, P Palese |
Nature Reviews Drug Discovery | 2015 |
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Immunological characterization of monoclonal antibodies used in rapid influenza diagnostic test for detection of the 2009 pandemic influenza A(H1N1)pdm09 infection
H Yi, MS Lee, JY Lee, HK Lee, C Kang |
The Journal of Microbiology | 2015 |
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Serological comparison of antibodies to avian influenza viruses, subtypes H5N2, H6N1, H7N3 and H7N9 between poultry workers and non-poultry workers in Taiwan in 2012
SY Huang, JR Yang, YJ Lin, CH Yang, MC Cheng, MT Liu, HS Wu, FY Chang |
Epidemiology and Infection | 2015 |
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Prospects of HA-Based Universal Influenza Vaccine
AM Hashem |
BioMed Research International | 2015 |
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Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
LC Lindesmith, MT Ferris, CW Mullan, J Ferreira, K Debbink, J Swanstrom, C Richardson, RR Goodwin, F Baehner, PM Mendelman, RF Bargatze, RS Baric, B Lopman |
PLoS Medicine | 2015 |
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Hemagglutinin stem reactive antibody response in individuals immunized with a seasonal influenza trivalent vaccine
X Zhao, K Qin, J Guo, D Wang, Z Li, W Zhu, L Liu, D Wang, Y Shu, J Zhou |
Protein & Cell | 2015 |
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Strategies to guide the antibody affinity maturation process
NA Doria-Rose, MG Joyce |
Current Opinion in Virology | 2015 |
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The use of pseudotypes to study viruses, virus sero-epidemiology and vaccination
EM Bentley, ST Mather, NJ Temperton |
Vaccine | 2015 |
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Heterosubtypic Protection Conferred by the Human Monoclonal Antibody PN-SIA28 against Influenza A Virus Lethal Infections in Mice
M Retamal, Y Abed, C Rhéaume, F Cappelletti, N Clementi, N Mancini, M Clementi, R Burioni, G Boivin |
Antimicrobial agents and chemotherapy | 2015 |
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Pseudotype-Based Neutralization Assays for Influenza: A Systematic Analysis
GW Carnell, F Ferrara, K Grehan, CP Thompson, NJ Temperton |
Frontiers in immunology | 2015 |
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The evolution within us
S Cobey, P Wilson, FA Matsen |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2015 |
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H5N1 Vaccine-Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem
AK Wheatley, JR Whittle, D Lingwood, M Kanekiyo, HM Yassine, SS Ma, SR Narpala, MS Prabhakaran, RA Matus-Nicodemos, RT Bailer, GJ Nabel, BS Graham, JE Ledgerwood, RA Koup, AB McDermott |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Masking of antigenic epitopes by antibodies shapes the humoral immune response to influenza
VI Zarnitsyna, AH Ellebedy, C Davis, J Jacob, R Ahmed, R Antia |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2015 |
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Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA)
SF Baker, A Nogales, FW Santiago, DJ Topham, L Martínez-Sobrido |
Vaccine | 2015 |
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B Cells and Functional Antibody Responses to Combat Influenza
G Lofano, A Kumar, O Finco, GD Giudice, S Bertholet |
Frontiers in immunology | 2015 |
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Ability To Develop Broadly Neutralizing HIV-1 Antibodies Is Not Restricted by the Germline Ig Gene Repertoire
C Scheepers, RK Shrestha, BE Lambson, KJ Jackson, IA Wright, D Naicker, M Goosen, L Berrie, A Ismail, N Garrett, QA Karim, SS Karim, PL Moore, SA Travers, L Morris |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
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Meta-Analysis and Potential Role of Preexisting Heterosubtypic Cellular Immunity Based on Variations in Disease Severity Outcomes for Influenza Live Viral Challenges in Humans
O Pleguezuelos, S Robinson, A Fernandez, GA Stoloff, W Caparrós-Wanderley, DW Pascual |
Clinical and vaccine immunology : CVI | 2015 |
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Serum Samples From Middle-aged Adults Vaccinated Annually with Seasonal Influenza Vaccines Cross-neutralize Some Potential Pandemic Influenza Viruses
W Wang, E Alvarado-Facundo, Q Chen, CM Anderson, D Scott, R Vassell, CD Weiss |
The Journal of Infectious Diseases | 2015 |
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Distinct germinal center selection at local sites shapes memory B cell response to viral escape
Y Adachi, T Onodera, Y Yamada, R Daio, M Tsuiji, T Inoue, K Kobayashi, T Kurosaki, M Ato, Y Takahashi |
Journal of Experimental Medicine | 2015 |
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Partial protection against 2009 pandemic influenza A (H1N1) of seasonal influenza vaccination and related regional factors: Updated systematic review and meta-analyses
Z Li, J Chen, Z Yan-ling, W Fu |
Human Vaccines & Immunotherapeutics | 2015 |
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Aging, cytomegalovirus (CMV) and influenza vaccine responses
D Frasca, BB Blomberg |
Human Vaccines & Immunotherapeutics | 2015 |
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Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain
B Cortina-Ceballos, EE Godoy-Lozano, J Téllez-Sosa, M Ovilla-Muñoz, H Sámano-Sánchez, A Aguilar-Salgado, RE Gómez-Barreto, H Valdovinos-Torres, I López-Martínez, R Aparicio-Antonio, MH Rodríguez, J Martínez-Barnetche |
Genome Medicine | 2015 |
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Respiratory Virus Vaccines
Broadbent AJ, Boonnak K, Subbarao K |
Mucosal Immunology | 2015 |
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Transient Humoral Protection against H5N1 Challenge after Seasonal Influenza Vaccination of Humans
R Roozendaal, J Tolboom, A Roos, S Riahi, J Theeuwsen, MV Bujny, V Klaren, HJ Korse, L Dekking, A Grootenhuis, GJ Weverling, W Koudstaal, J Goudsmit, K Radošević, GP Kobinger |
PloS one | 2014 |
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IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria
KK Hwang, AM Trama, DM Kozink, X Chen, K Wiehe, AJ Cooper, SM Xia, M Wang, DJ Marshall, J Whitesides, M Alam, GD Tomaras, SL Allen, KR Rai, J McKeating, R Catera, XJ Yan, CC Chu, G Kelsoe, HX Liao, N Chiorazzi, BF Haynes |
PloS one | 2014 |
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Universal immunity to influenza must outwit immune evasion
S Quiñones-Parra, L Loh, LE Brown, K Kedzierska, SA Valkenburg |
Frontiers in microbiology | 2014 |
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Seasonal Influenza Vaccination Is the Strongest Correlate of Cross-Reactive Antibody Responses in Migratory Bird Handlers
CM Oshansky, SS Wong, T Jeevan, HS Smallwood, RJ Webby, SC Shafir, PG Thomas |
mBio | 2014 |
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Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in Macaques
NW Florek, JT Weinfurter, S Jegaskanda, JN Brewoo, TD Powell, GR Young, SC Das, M Hatta, KW Broman, O Hungnes, SG Dudman, Y Kawaoka, SJ Kent, DT Stinchcomb, JE Osorio, TC Friedrich |
Journal of virology | 2014 |
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Options and Obstacles for Designing a Universal Influenza Vaccine
Y Jang, B Seong |
Viruses | 2014 |
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Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses
Y Avnir, AS Tallarico, Q Zhu, AS Bennett, G Connelly, J Sheehan, J Sui, A Fahmy, CY Huang, G Cadwell, LA Bankston, AT McGuire, L Stamatatos, G Wagner, RC Liddington, WA Marasco |
PLoS pathogens | 2014 |
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Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections
JR Chen, YH Yu, YC Tseng, WL Chiang, MF Chiang, YA Ko, YK Chiu, HH Ma, CY Wu, JT Jan, KI Lin, C Ma, CH Wong |
Proceedings of the National Academy of Sciences | 2014 |
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Fast vaccine design and development based on correlates of protection (COPs): Influenza as a trendsetter
C Els, S Mjaaland, L Næss, J Sarkadi, E Gonczol, KS Korsholm, JU Hansen, J Jonge, G Kersten, J Warner, A Semper, C Kruiswijk, F Oftung |
Human Vaccines & Immunotherapeutics | 2014 |
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Diversity of the murine antibody response targeting influenza A(H1N1pdm09) hemagglutinin
JR Wilson, WP Tzeng, A Spesock, N Music, Z Guo, R Barrington, J Stevens, RO Donis, JM Katz, IA York |
Virology | 2014 |
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CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
GV Zuccarino-Catania, S Sadanand, FJ Weisel, MM Tomayko, H Meng, SH Kleinstein, KL Good-Jacobson, MJ Shlomchik |
Nature Immunology | 2014 |
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A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response
KR Talaat, CJ Luke, S Khurana, J Manischewitz, LR King, BA McMahon, RA Karron, KD Lewis, J Qin, DA Follmann, H Golding, KM Neuzil, K Subbarao |
The Journal of Infectious Diseases | 2014 |
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Distinct Cross-reactive B-Cell Responses to Live Attenuated and Inactivated Influenza Vaccines
S Sasaki, TH Holmes, RA Albrecht, A Garcia-Sastre, CL Dekker, XS He, HB Greenberg |
The Journal of Infectious Diseases | 2014 |
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Universal Influenza Vaccines, a Dream to Be Realized Soon
H Zhang, L Wang, R Compans, BZ Wang |
Viruses | 2014 |
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Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes
JG Magadán, MO Altman, WL Ince, HD Hickman, J Stevens, A Chevalier, D Baker, PC Wilson, R Ahmed, JR Bennink, JW Yewdell |
PLoS pathogens | 2014 |
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The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency
SE Hufton, P Risley, CR Ball, D Major, OG Engelhardt, S Poole |
PloS one | 2014 |
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Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans
AH Ellebedy, F Krammer, GM Li, MS Miller, C Chiu, J Wrammert, CY Chang, CW Davis, M McCausland, R Elbein, S Edupuganti, P Spearman, SF Andrews, PC Wilson, A Garcia-Sastre, MJ Mulligan, AK Mehta, P Palese, R Ahmed |
Proceedings of the National Academy of Sciences | 2014 |
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Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies
E Molesti, E Wright, C Terregino, R Rahman, G Cattoli, NJ Temperton |
Journal of Immunology Research | 2014 |
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Discordant correlation between serological assays observed when measuring heterosubtypic responses against avian influenza H5 and H7 viruses in unexposed individuals
E Molesti, F Ferrara, G Lapini, E Montomoli, N Temperton |
BioMed Research International | 2014 |
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Assessment of influenza virus hemagglutinin stalk-based immunity in ferrets
F Krammer, R Hai, M Yondola, GS Tan, VH Leyva-Grado, AB Ryder, MS Miller, JK Rose, P Palese, A García-Sastre, RA Albrecht |
Journal of virology | 2014 |
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Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages
JR Whittle, AK Wheatley, L Wu, D Lingwood, M Kanekiyo, SS Ma, SR Narpala, HM Yassine, GM Frank, JW Yewdell, JE Ledgerwood, CJ Wei, AB McDermott, BS Graham, RA Koup, GJ Nabel |
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Rapid development of broadly influenza neutralizing antibodies through redundant mutations
L Pappas, M Foglierini, L Piccoli, NL Kallewaard, F Turrini, C Silacci, B Fernandez-Rodriguez, G Agatic, I Giacchetto-Sasselli, G Pellicciotta, F Sallusto, Q Zhu, E Vicenzi, D Corti, A Lanzavecchia |
Nature | 2014 |
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Passive Broad-Spectrum Influenza Immunoprophylaxis
CM Berry, WJ Penhale, MY Sangster |
Influenza Research and Treatment | 2014 |
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Influenza Vaccines: A Moving Interdisciplinary Field
M Schotsaert, A García-Sastre |
Viruses | 2014 |
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Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future
C Trombetta, D Perini, S Mather, N Temperton, E Montomoli |
Human vaccines | 2014 |
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Modified Vaccinia Virus Ankara (MVA) as Production Platform for Vaccines against Influenza and Other Viral Respiratory Diseases
A Altenburg, J Kreijtz, R Vries, F Song, R Fux, G Rimmelzwaan, G Sutter, A Volz |
Viruses | 2014 |
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Traditional and new influenza vaccines
SS Wong, RJ Webby |
Clinical microbiology reviews | 2013 |
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Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1
Z Zhu, P Prabakaran, W Chen, CC Broder, R Gong, DS Dimitrov |
Virologica Sinica | 2013 |
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Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies
M Kanekiyo, CJ Wei, HM Yassine, PM McTamney, JC Boyington, JR Whittle, SS Rao, WP Kong, L Wang, GJ Nabel |
Nature | 2013 |
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The prospects and challenges of universal vaccines for influenza
K Subbarao, Y Matsuoka |
Trends in Microbiology | 2013 |
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Advances in structure-based vaccine design
DW Kulp, WR Schief |
Current Opinion in Virology | 2013 |
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Generation of human neutralizing monoclonal antibodies against the 2009 pandemic H1N1 virus from peripheral blood memory B lymphocytes
H Wang, C Ma, Y Lu, X Ji, Y Pang, F Hua, L Cui, D Ba, W He |
Cellular and Molecular Immunology | 2013 |
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To dream the impossible dream: universal influenza vaccination
JW Yewdell |
Current Opinion in Virology | 2013 |
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Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis
MS Miller, TJ Gardner, F Krammer, LC Aguado, D Tortorella, CF Basler, P Palese |
Science Translational Medicine | 2013 |
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Influenza virus hemagglutinin stalk-based antibodies and vaccines
F Krammer, P Palese |
Current Opinion in Virology | 2013 |
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Emergence of New Pandemic GII.4 Sydney Norovirus Strain Correlates With Escape From Herd Immunity
K Debbink, LC Lindesmith, EF Donaldson, V Costantini, M Beltramello, D Corti, J Swanstrom, A Lanzavecchia, J Vinje, RS Baric |
The Journal of Infectious Diseases | 2013 |
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The diversity of the immune response to the A2 domain of human factor VIII
RC Markovitz, JF Healey, ET Parker, SL Meeks, P Lollar |
Blood | 2013 |
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Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses
I Margine, F Krammer, R Hai, NS Heaton, GS Tan, SA Andrews, JA Runstadler, PC Wilson, RA Albrecht, A García-Sastre, P Palese |
Journal of virology | 2013 |
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Immunobiology of influenza vaccines
MM Lorenzo, MJ Fenton |
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A novel influenza virus hemagglutinin-respiratory syncytial virus (RSV) fusion protein subunit vaccine against influenza and RSV
TM Turner, LP Jones, SM Tompkins, RA Tripp |
Journal of virology | 2013 |
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A common solution to group 2 influenza virus neutralization
RH Friesen, PS Lee, EJ Stoop, RM Hoffman, DC Ekiert, G Bhabha, W Yu, J Juraszek, W Koudstaal, M Jongeneelen, HJ Korse, C Ophorst, EC der Linden, M Throsby, MJ Kwakkenbos, AQ Bakker, T Beaumont, H Spits, T Kwaks, R Vogels, AB Ward, J Goudsmit, IA Wilson |
Proceedings of the National Academy of Sciences | 2013 |
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The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus
R Keating, T Hertz, M Wehenkel, TL Harris, BA Edwards, JL McClaren, SA Brown, S Surman, ZS Wilson, P Bradley, J Hurwitz, H Chi, PC Doherty, PG Thomas, MA McGargill |
Nature Immunology | 2013 |
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The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
D Sok, U Laserson, J Laserson, Y Liu, F Vigneault, JP Julien, B Briney, A Ramos, KF Saye, K Le, A Mahan, S Wang, M Kardar, G Yaari, LM Walker, BB Simen, EP st John, PY Chan-Hui, K Swiderek, SH Kleinstein, SH Kleinstein, G Alter, MS Seaman, AK Chakraborty, D Koller, IA Wilson, GM Church, DR Burton, P Poignard |
PLoS pathogens | 2013 |
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Comparative serological assays for the study of h5 and h7 avian influenza viruses
E Molesti, A Milani, C Terregino, G Cattoli, NJ Temperton |
Influenza Research and Treatment | 2013 |
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Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques
S Jegaskanda, TH Amarasena, KL Laurie, HX Tan, J Butler, MS Parsons, S Alcantara, J Petravic, MP Davenport, AC Hurt, PC Reading, SJ Kent |
Journal of virology | 2013 |
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Heterosubtypic antiviral activity of hemagglutinin-specific antibodies induced by intranasal immunization with inactivated influenza viruses in mice
M Muramatsu, R Yoshida, H Miyamoto, D Tomabechi, M Kajihara, J Maruyama, T Kimura, R Manzoor, K Ito, A Takada |
PloS one | 2013 |
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High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature
AD Henn, S Wu, X Qiu, M Ruda, M Stover, H Yang, Z Liu, SL Welle, J Holden-Wiltse, H Wu, MS Zand |
Scientific Reports | 2013 |
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An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant
NE Stevens, CK Fraser, M Alsharifi, MP Brown, KR Diener, JD Hayball |
PloS one | 2013 |
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Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases
W Meng, W Pan, AJ Zhang, Z Li, G Wei, L Feng, Z Dong, C Li, X Hu, C Sun, Q Luo, KY Yuen, N Zhong, L Chen |
PloS one | 2013 |
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B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination
MY Sangster, J Baer, FW Santiago, T Fitzgerald, NA Ilyushina, A Sundararajan, AD Henn, F Krammer, H Yang, CJ Luke, MS Zand, PF Wright, JJ Treanor, DJ Topham, K Subbarao |
Clinical and vaccine immunology : CVI | 2013 |
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Infection with 2009 H1N1 influenza virus primes for immunological memory in human nose-associated lymphoid tissue, offering cross-reactive immunity to H1N1 and avian H5N1 viruses
WH Mahallawi, AV Kasbekar, MS McCormick, K Hoschler, N Temperton, SC Leong, H Beer, F Ferrara, PS McNamara, Q Zhang |
Journal of virology | 2013 |
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Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China
CL Wu, J Lu, MH Wang, X Lv, Y Chen, H Kung, B Zee, X Cheng, ML He |
PloS one | 2013 |
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Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination
EG Huijskens, J Reimerink, PG Mulder, J Beek, A Meijer, E Bruin, I Friesema, MD de Jong, GF Rimmelzwaan, MF Peeters, JW Rossen, M Koopmans |
PloS one | 2013 |
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New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion
A Basu, A Antanasijevic, M Wang, B Li, DM Mills, JA Ames, PJ Nash, JD Williams, NP Peet, DT Moir, MN Prichard, KA Keith, DL Barnard, M Caffrey, L Rong, TL Bowlin |
Journal of virology | 2013 |
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Immune responses to infection with H5N1 influenza virus.
Rimmelzwaan GF, Katz JM |
Virus Research | 2013 |
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Immunological assessment of influenza vaccines and immune correlates of protection.
Reber A, Katz J |
Expert Review of Vaccines | 2013 |
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Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses
JC Krause, T Tsibane, TM Tumpey, CJ Huffman, R Albrecht, DL Blum, I Ramos, A Fernandez-Sesma, KM Edwards, A García-Sastre, CF Basler, JE Crowe |
Journal of virology | 2012 |
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HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role
G Sautto, N Mancini, L Solforosi, RA Diotti, M Clementi, R Burioni |
Clinical and Developmental Immunology | 2012 |
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A human CD4+ T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virus
JA Babon, J Cruz, FA Ennis, L Yin, M Terajima |
Journal of virology | 2012 |
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The human side of influenza
CM Oshansky, PG Thomas |
Journal of leukocyte biology | 2012 |
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Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem
CA Thomson, Y Wang, LM Jackson, M Olson, W Wang, A Liavonchanka, L Keleta, V Silva, S Diederich, RB Jones, J Gubbay, J Pasick, M Petric, F Jean, VG Allen, EG Brown, JM Rini, JW Schrader |
Frontiers in immunology | 2012 |
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Passive immune neutralization strategies for prevention and control of influenza A infections
J Ye, H Shao, DR Perez |
Immunotherapy | 2012 |
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Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype
M Terajima, JA Babon, FA Ennis |
mBio | 2012 |
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Seroconversion to Seasonal Influenza Viruses after A(H1N1)pdm09 Virus Infection, Quebec, Canada
M Baz, J Papenburg, ME Hamelin, M Ouakki, DM Skowronski, GD Serres, G Boivin |
Emerging infectious diseases | 2012 |
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Re-Engaging Cross-Reactive Memory B Cells: The Influenza Puzzle
AH Ellebedy, R Ahmed |
Frontiers in immunology | 2012 |
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A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
DD Marco, N Clementi, N Mancini, L Solforosi, GJ Moreno, X Sun, TM Tumpey, LV Gubareva, V Mishin, M Clementi, R Burioni |
PloS one | 2012 |
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Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses
N Pica, R Hai, F Krammer, TT Wang, J Maamary, D Eggink, GS Tan, JC Krause, T Moran, CR Stein, D Banach, J Wrammert, RB Belshe, A García-Sastre, P Palese |
Proceedings of the National Academy of Sciences | 2012 |
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Structural and genetic basis for development of broadly neutralizing influenza antibodies
D Lingwood, PM McTamney, HM Yassine, JR Whittle, X Guo, JC Boyington, CJ Wei, GJ Nabel |
Nature | 2012 |
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Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells
GM Li, C Chiu, J Wrammert, M McCausland, SF Andrews, NY Zheng, JH Lee, M Huang, X Qu, S Edupuganti, M Mulligan, SR Das, JW Yewdell, AK Mehta, PC Wilson, R Ahmed |
Proceedings of the National Academy of Sciences | 2012 |
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HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design
M Bonsignori, SM Alam, HX Liao, L Verkoczy, GD Tomaras, BF Haynes, MA Moody |
Trends in Microbiology | 2012 |
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N-Linked Glycosylation in the Hemagglutinin of Influenza A Viruses
JI Kim, MS Park |
Yonsei Medical Journal | 2012 |
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Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systems
FW Santiago, KL Emo, T Fitzgerald, JJ Treanor, DJ Topham |
Vaccine | 2012 |
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Tools to therapeutically harness the human antibody response
PC Wilson, SF Andrews |
Nature Reviews Immunology | 2012 |
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Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity
PS Lee, R Yoshida, DC Ekiert, N Sakai, Y Suzuki, A Takada, IA Wilson |
Proceedings of the National Academy of Sciences | 2012 |
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Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA
JP Julien, PS Lee, IA Wilson |
Immunological Reviews | 2012 |
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1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans
MS Miller, T Tsibane, F Krammer, R Hai, S Rahmat, CF Basler, P Palese |
The Journal of Infectious Diseases | 2012 |
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Role of T-cell epitope-based vaccine in prophylactic and therapeutic applications
JS Testa, R Philip |
Future Virology | 2012 |
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Heterovariant Cross-Reactive B-Cell Responses Induced by the 2009 Pandemic Influenza Virus A Subtype H1N1 Vaccine
XS He, S Sasaki, J Baer, S Khurana, H Golding, JJ Treanor, DJ Topham, MY Sangster, H Jin, CL Dekker, K Subbarao, HB Greenberg |
The Journal of Infectious Diseases | 2012 |
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Unraveling of a neutralization mechanism by two human antibodies against conserved epitopes in the globular head of H5 hemagglutinin
M Qian, H Hu, T Zuo, G Wang, L Zhang, P Zhou |
Journal of virology | 2012 |
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Increased immunogenicity and protective efficacy of influenza M2e fused to a tetramerizing protein
AM Andersson, KO Håkansson, BA Jensen, D Christensen, P Andersen, AR Thomsen, JP Christensen |
PloS one | 2012 |
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Oligomeric recombinant H5 HA1 vaccine produced in bacteria protects ferrets from homologous and heterologous wild-type H5N1 influenza challenge and controls viral loads better than subunit H5N1 vaccine by eliciting high-affinity antibodies
S Verma, M Dimitrova, A Munjal, J Fontana, CJ Crevar, DM Carter, TM Ross, S Khurana, H Golding |
Journal of virology | 2012 |
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A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin
A Schneemann, JA Speir, GS Tan, R Khayat, DC Ekiert, Y Matsuoka, IA Wilson |
Journal of virology | 2012 |
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A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses
F Zhou, G Wang, P Buchy, Z Cai, H Chen, Z Chen, G Cheng, XF Wan, V Deubel, P Zhou |
Journal of virology | 2012 |
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Influenza viruses expressing chimeric hemagglutinins: globular head and stalk domains derived from different subtypes
R Hai, F Krammer, GS Tan, N Pica, D Eggink, J Maamary, I Margine, RA Albrecht, P Palese |
Journal of virology | 2012 |
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Influenza virus H1N1pdm09 infections in the young and old: evidence of greater antibody diversity and affinity for the hemagglutinin globular head domain (HA1 Domain) in the elderly than in young adults and children
N Verma, M Dimitrova, DM Carter, CJ Crevar, TM Ross, H Golding, S Khurana |
Journal of virology | 2012 |
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Neutralization of influenza A viruses by insertion of a single antibody loop into the receptor binding site
DC Ekiert, AK Kashyap, J Steel, A Rubrum, G Bhabha, R Khayat, JH Lee, MA Dillon, RE O’Neil, AM Faynboym, M Horowitz, L Horowitz, AB Ward, P Palese, R Webby, RA Lerner, RR Bhatt, IA Wilson |
Nature | 2012 |
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Vaccines for the future: learning from human immunology
ED Gregorio, R Rappuoli |
Microbial Biotechnology | 2012 |
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A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses
H Hu, J Voss, G Zhang, P Buchy, T Zuo, L Wang, F Wang, F Zhou, G Wang, C Tsai, L Calder, SJ Gamblin, L Zhang, V Deubel, B Zhou, JJ Skehel, P Zhou |
Journal of virology | 2012 |
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Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient.
Hu W, Chen A, Miao Y, Xia S, Ling Z, Xu K, Wang T, Xu Y, Cui J, Wu H, Hu G, Tian L, Wang L, Shu Y, Ma X, Xu B, Zhang J, Lin X, Bian C, Sun B |
Virology | 2012 |
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Wide Prevalence of Heterosubtypic Broadly Neutralizing Human Anti-Influenza A Antibodies
J Sui, J Sheehan, WC Hwang, LA Bankston, SK Burchett, CY Huang, RC Liddington, JH Beigel, WA Marasco |
Clinical Infectious Diseases | 2011 |
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H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination
MA Moody, R Zhang, EB Walter, CW Woods, GS Ginsburg, MT McClain, TN Denny, X Chen, S Munshaw, DJ Marshall, JF Whitesides, MS Drinker, JD Amos, TC Gurley, JA Eudailey, A Foulger, KR DeRosa, R Parks, RR Meyerhoff, JS Yu, DM Kozink, BE Barefoot, EA Ramsburg, S Khurana, H Golding, NA Vandergrift, SM Alam, GD Tomaras, TB Kepler, G Kelsoe, HX Liao, BF Haynes |
PloS one | 2011 |
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Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
J Glanville, TC Kuo, HC Büdingen, L Guey, J Berka, PD Sundar, G Huerta, GR Mehta, JR Oksenberg, SL Hauser, DR Cox, A Rajpal, J Pons |
Proceedings of the National Academy of Sciences | 2011 |
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Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
J Wrammert, D Koutsonanos, GM Li, S Edupuganti, J Sui, M Morrissey, M McCausland, I Skountzou, M Hornig, WI Lipkin, A Mehta, B Razavi, CD Rio, NY Zheng, JH Lee, M Huang, Z Ali, K Kaur, S Andrews, RR Amara, Y Wang, SR Das, CD O'Donnell, JW Yewdell, K Subbarao, WA Marasco, MJ Mulligan, R Compans, R Ahmed, PC Wilson |
Journal of Experimental Medicine | 2011 |
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Antibodies Against Conserved Antigens Provide Opportunities for Reform in Influenza Vaccine Design
DA Kaminski, FE Lee |
Frontiers in immunology | 2011 |
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Influenza vaccine responses in older adults
JE McElhaney |
Ageing Research Reviews | 2011 |
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Heterosubtypic antibody response elicited with seasonal influenza vaccine correlates partial protection against highly pathogenic H5N1 virus
H Ding, C Tsai, F Zhou, P Buchy, V Deubel, P Zhou |
PloS one | 2011 |
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Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines
ML Hillaire, AD Osterhaus, GF Rimmelzwaan |
Journal of Biomedicine and Biotechnology | 2011 |
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Immunogenicity Profile of a 3.75-μg Hemagglutinin Pandemic rH5N1 Split Virion AS03A-Adjuvanted Vaccine in Elderly Persons: A Randomized Trial
S Heijmans, MD Meulemeester, P Reynders, D Giet, E Demanet, PY Devresse, G Icardi, M Dramé, F Roman, P Gillard |
The Journal of Infectious Diseases | 2011 |
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Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 Mice
ME Lorenzo, A Hodgson, DP Robinson, JB Kaplan, A Pekosz, SL Klein |
Vaccine | 2011 |
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MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines
S Khurana, N Verma, JW Yewdell, AK Hilbert, F Castellino, M Lattanzi, GD Giudice, R Rappuoli, H Golding |
Science Translational Medicine | 2011 |
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Viva la revolución: rethinking influenza A virus antigenic drift
JW Yewdell |
Current Opinion in Virology | 2011 |
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Cross-neutralizing antibodies to pandemic 2009 H1N1 and recent seasonal H1N1 influenza A strains influenced by a mutation in hemagglutinin subunit 2
W Wang, CM Anderson, CJ de Feo, M Zhuang, H Yang, R Vassell, H Xie, Z Ye, D Scott, CD Weiss |
PLoS pathogens | 2011 |
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Screening of random peptide library of hemagglutinin from pandemic 2009 A(H1N1) influenza virus reveals unexpected antigenically important regions
W Xu, L Han, Z Lin |
PloS one | 2011 |
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Targeting B cell responses in universal influenza vaccine design
K Kaur, M Sullivan, PC Wilson |
Trends in Immunology | 2011 |
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DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials
JE Ledgerwood, CJ Wei, Z Hu, IJ Gordon, ME Enama, CS Hendel, PM McTamney, MB Pearce, HM Yassine, JC Boyington, R Bailer, TM Tumpey, RA Koup, JR Mascola, GJ Nabel, BS Graham |
The Lancet Infectious Diseases | 2011 |
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Evaluation of age-related differences in the immunogenicity of a G9 H9N2 influenza vaccine
RL Atmar, WA Keitel, JM Quarles, TR Cate, SM Patel, D Nino, J Wells, N Arden, K Guo, H Hill, RB Couch |
Vaccine | 2011 |
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Clonal B cells in patients with hepatitis C virus–associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset
ED Charles, C Brunetti, S Marukian, KD Ritola, AH Talal, K Marks, IM Jacobson, CM Rice, LB Dustin |
Blood | 2011 |
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A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes
N Clementi, DD Marco, N Mancini, L Solforosi, GJ Moreno, LV Gubareva, V Mishin, AD Pietro, E Vicenzi, AG Siccardi, M Clementi, R Burioni |
PloS one | 2011 |
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Minor Changes in the Hemagglutinin of Influenza A(H1N1)2009 Virus Alter Its Antigenic Properties
M Strengell, N Ikonen, T Ziegler, I Julkunen |
PloS one | 2011 |
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A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses
DC Ekiert, RH Friesen, G Bhabha, T Kwaks, M Jongeneelen, W Yu, C Ophorst, F Cox, HJ Korse, B Brandenburg, R Vogels, JP Brakenhoff, R Kompier, MH Koldijk, LA Cornelissen, LL Poon, M Peiris, W Koudstaal, IA Wilson, J Goudsmit |
Science (New York, N.Y.) | 2011 |
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Structural basis of influenza virus neutralization
T Han, WA Marasco |
Annals of the New York Academy of Sciences | 2011 |
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Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence
JC Krause, T Tsibane, TM Tumpey, CJ Huffman, BS Briney, SA Smith, CF Basler, JE Crowe |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Comprehensive analysis of pathogen-specific antibody response in vivo based on an antigen library displayed on surface of yeast
T Zuo, X Shi, Z Liu, L Guo, Q Zhao, T Guan, X Pan, N Jia, W Cao, B Zhou, M Goldin, L Zhang |
The Journal of biological chemistry | 2011 |
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Seasonal H1N1 Influenza Virus Infection Induces Cross-Protective Pandemic H1N1 Virus Immunity through a CD8-Independent, B Cell-Dependent Mechanism
Y Fang, D Banner, AA Kelvin, SS Huang, CJ Paige, SA Corfe, KP Kane, RC Bleackley, T Rowe, AJ Leon, DJ Kelvin |
Journal of virology | 2011 |
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Enhanced Growth of Influenza Vaccine Seed Viruses in Vero Cells Mediated by Broadening the Optimal pH Range for Virus Membrane Fusion
S Murakami, T Horimoto, M Ito, R Takano, H Katsura, M Shimojima, Y Kawaoka |
Journal of virology | 2011 |
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Highly Pathogenic Avian Influenza Virus Subtype H5N1 Escaping Neutralization: More than HA Variation
D Hoper, D Kalthoff, B Hoffmann, M Beer |
Journal of virology | 2011 |
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Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies
M Terajima, J Cruz, MD Co, JH Lee, K Kaur, PC Wilson, FA Ennis |
Journal of virology | 2011 |
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A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin
JC Krause, T Tsibane, TM Tumpey, CJ Huffman, CF Basler, JE Crowe |
Journal of virology | 2011 |
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A Flow Cytometry-Based Strategy to Identify and Express IgM from VH1-69+ Clonal Peripheral B Cells
ED Charles, MI Orloff, LB Dustin |
Journal of Immunological Methods | 2010 |
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A phase II, open-label, multicentre study to evaluate the immunogenicity and safety of an adjuvanted prepandemic (H5N1) influenza vaccine in healthy Japanese adults
H Nagai, H Ikematsu, K Tenjinbaru, A Maeda, M Dramé, FP Roman |
BMC Infectious Diseases | 2010 |
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Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses
AG 3rd, OA Olsen, TC Cox, M Renshaw, PW Hammond, PY Chan-Hui, JL Mitcham, W Cieplak, SM Stewart, ML Grantham, A Pekosz, M Kiso, K Shinya, M Hatta, Y Kawaoka, M Moyle |
Proceedings of the National Academy of Sciences | 2010 |
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Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein
M Sedegah, Y Kim, B Peters, S McGrath, H Ganeshan, J Lejano, E Abot, G Banania, M Belmonte, R Sayo, F Farooq, DL Doolan, D Regis, C Tamminga, I Chuang, JT Bruder, CR King, CF Ockenhouse, B Faber, E Remarque, MR Hollingdale, TL Richie, A Sette |
Malaria Journal | 2010 |
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The wages of original antigenic sin
DM Morens, DS Burke, SB Halstead |
Emerging infectious diseases | 2010 |
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From Vaccines to Memory and Back
F Sallusto, A Lanzavecchia, K Araki, R Ahmed |
Immunity | 2010 |
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Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine
GJ Nabel, AS Fauci |
Nature Medicine | 2010 |
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Virus neutralising activity of African fruit bat (Eidolon helvum) sera against emerging lyssaviruses.
Wright E, Hayman DT, Vaughan A, Temperton NJ, Wood JL, Cunningham AA, Suu-Ire R, Weiss RA, Fooks AR |
Virology | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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