The purpose of this study was to explore whether repeated exposure to aerosolized ovalbumin (OVA) in the context of local expression of GM-CSF can initiate a Th2-driven, eosinophilic inflammation in the airways. On day -1, Balb/c mice were infected intranasally with an adenovirus construct expressing GM-CSF (Ad/GM-CSF). From day 0 to day 9 mice were exposed daily to an OVA aerosol. Mice exposed to OVA alone did not show any evidence of airway inflammation. Mice receiving both Ad/GM-CSF and aerosolized OVA exhibited marked airway inflammation characterized by eosinophilia and goblet cell hyperplasia. Migration of eosinophils into the airway was preceded by a rise in IL-5 and IL-4. Both IL-5 and class II MHC were critically required to generate airway eosinophilia. After resolution, airway eosinophilia was reconstituted after a single OVA exposure. Flow cytometric analysis of dispersed lung cells revealed an increase in macrophages and dendritic cells expressing B7.1 and B7.2, and expansion of activated (CD69-expressing) CD4 and CD8 T cells in mice exposed to OVA and Ad/GM-CSF. Our data indicate that expression of GM-CSF in the airway compartment increases local antigen presentation capacity, and concomitantly facilitates the development of an antigen-specific, eosinophilic inflammatory response to an otherwise innocuous antigen.
M R Stämpfli, R E Wiley, G S Neigh, B U Gajewska, X F Lei, D P Snider, Z Xing, M Jordana
Title and authors | Publication | Year |
---|---|---|
Innate Immunity and Asthma Exacerbations: Insights from Human Models
Alladina J, Medoff BD, Cho JL |
Immunological reviews | 2025 |
Crosstalk between CD64(+)MHCII(+) macrophages and CD4(+) T cells drives joint pathology during chikungunya.
Lum FM, Chan YH, Teo TH, Becht E, Amrun SN, Teng KW, Hartimath SV, Yeo NK, Yee WX, Ang N, Torres-Ruesta AM, Fong SW, Goggi JL, Newell EW, Renia L, Carissimo G, Ng LF |
EMBO Molecular Medicine | 2024 |
Promising Cytokine Adjuvants for Enhancing Tuberculosis Vaccine Immunity
Cao X, Fu YX, Peng H |
Human vaccines | 2024 |
GM-CSF-dependent CD301b+ lung dendritic cells confer tolerance to inhaled allergens
Wilkinson CL, Nakano K, Grimm SA, Whitehead GS, Arao Y, Blackshear PJ, Karmaus PW, Fessler MB, Cook DN, Nakano H |
Research square | 2024 |
Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers
Hargitai R, Parráková L, Szatmári T, Monfort-Lanzas P, Galbiati V, Audouze K, Jornod F, Staal YC, Burla S, Chary A, Gutleb AC, Lumniczky K, Vandebriel RJ, Gostner JM |
2024 | |
Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung.
Wu YC, Moon HG, Bindokas VP, Phillips EH, Park GY, Lee SS |
American journal of respiratory cell and molecular biology | 2023 |
Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases
EO Gubernatorova, OA Namakanova, EA Gorshkova, AD Medvedovskaya, SA Nedospasov, MS Drutskaya |
Frontiers in immunology | 2021 |
GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation.
Kaur K, Bachus H, Lewis C, Papillion AM, Rosenberg AF, Ballesteros-Tato A, León B |
Cell Reports | 2021 |
Migration-induced cell shattering due to DOCK8 deficiency causes a type 2–biased helper T cell response
C Schneider, C Shen, AA Gopal, T Douglas, B Forestell, KD Kauffman, D Rogers, P Artusa, Q Zhang, H Jing, AF Freeman, DL Barber, IL King, M Saleh, PW Wiseman, HC Su, JN Mandl |
Nature Immunology | 2020 |
Epithelial cell-derived cytokines: more than just signaling the alarm
Florence Roan, Kazushige Ninomiya, Steven Ziegler |
Journal of Clinical Investigation | 2019 |
Endothelial Cells in the Innate Response to Allergens and Initiation of Atopic Asthma
Kewal Asosingh, Kelly Weiss, Kimberly Queisser, Nicholas Wanner, Mei Yin, Mark A. Aronica, Serpil Erzurum |
Journal of Clinical Investigation | 2018 |
Cytokines in sensitization to aeroallergens
M Albrecht, AM Dittrich |
2018 | |
The TH2-polarizing function of atopic interleukin 17 receptor B–positive dendritic cells up-regulated by lipopolysaccharide
R Zheng, FH Chen, WX Gao, D Wang, QT Yang, K Wang, YY Lai, J Deng, LJ Jiang, YQ Sun, JB Shi |
Annals of Allergy, Asthma & Immunology | 2017 |
Allergy Prevention and Exacerbation
CB Schmidt-Weber |
2017 | |
The epithelial barrier and immunoglobulin A system in allergy
FM Carlier, Y Sibille, C Pilette |
Clinical & Experimental Allergy | 2016 |
Immunomodulation by gastrointestinal carbon black nanoparticle exposure in ovalbumin T cell receptor transgenic mice
JH Fine, GS Bondy, L Coady, B Pearce, N Ross, AF Tayabali, S Halappanavar, D Caldwell, I Curran, DE Lefebvre |
Nanotoxicology | 2016 |
PARP inhibition treatment in a nonconventional experimental mouse model of chronic asthma
R Zaffini, RD Paola, S Cuzzocrea, M Menegazzi |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2016 |
A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells
N Wang, D Yan, Y Liu, Y Liu, X Gu, J Sun, F Long, S Jiang |
Respiratory Research | 2016 |
GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen
A Sheih, WC Parks, SF Ziegler |
Mucosal Immunology | 2016 |
CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation
B Causton, RA Ramadas, JL Cho, K Jones, A Pardo-Saganta, J Rajagopal, RJ Xavier, BD Medoff |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
GM-CSF: An immune modulatory cytokine that can suppress autoimmunity
P Bhattacharya, M Thiruppathi, HA Elshabrawy, K Alharshawi, P Kumar, BS Prabhakar |
Cytokine | 2015 |
Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils
LY Liu, H Wang, JJ Xenakis, LA Spencer |
Allergy | 2015 |
GM-CSF-Licensed CD11b+ Lung Dendritic Cells Orchestrate Th2 Immunity to Blomia tropicalis
Q Zhou, AW Ho, A Schlitzer, Y Tang, KH Wong, FH Wong, YL Chua, V Angeli, A Mortellaro, F Ginhoux, DM Kemeny |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
Allergen Ligands in the Initiation of Allergic Sensitization
WR Thomas |
Current Allergy and Asthma Reports | 2014 |
Alveolar macrophages are sentinels of murine pulmonary homeostasis following inhaled antigen challenge
SA Mathie, KL Dixon, SA Walker, V Tyrrell, M Mondhe, VB O'Donnell, LG Gregory, CM Lloyd |
Allergy | 2014 |
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
GF Weber, BG Chousterman, I Hilgendorf, CS Robbins, I Theurl, LM Gerhardt, Y Iwamoto, TD Quach, M Ali, JW Chen, TL Rothstein, M Nahrendorf, R Weissleder, FK Swirski |
Journal of Experimental Medicine | 2014 |
A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure
A Llop-Guevara, DK Chu, TD Walker, S Goncharova, R Fattouh, JS Silver, CL Moore, JL Xie, PM O'Byrne, AJ Coyle, R Kolbeck, AA Humbles, MR Stämpfli, M Jordana |
PloS one | 2014 |
A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure
A Llop-Guevara, DK Chu, TD Walker, S Goncharova, R Fattouh, JS Silver, CL Moore, JL Xie, PM O’Byrne, AJ Coyle, R Kolbeck, AA Humbles, MR Stämpfli, M Jordana, HW Chu |
PloS one | 2014 |
Molecular mechanisms and physiology of disease
N Maulik, T Karagiannis |
2014 | |
Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells⋆
L Xue, M Salimi, I Panse, JM Mjösberg, AN McKenzie, H Spits, P Klenerman, G Ogg |
Journal of Allergy and Clinical Immunology | 2013 |
Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration
S Jang, J Smit, LE Kallal, NW Lukacs |
Journal of leukocyte biology | 2013 |
Dexamethasone reduces IL-17 and Tim-3 expression in BALF of asthmatic mice
X Lu, KS McCoy, W Hu, J Xu, H Wang, P Chen, H Chen |
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2013 |
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite
ZG Chen, TT Zhang, HT Li, FH Chen, XL Zou, JZ Ji, H Chen |
PloS one | 2013 |
Dysregulation of alveolar macrophages unleashes dendritic cell–mediated mechanisms of allergic airway inflammation
JF Lauzon-Joset, D Marsolais, A Langlois, EY Bissonnette |
Mucosal Immunology | 2013 |
A novel subset of helper T cells promotes immune responses by secreting GM-CSF
J Zhang, AI Roberts, C Liu, G Ren, G Xu, L Zhang, S Devadas, Y Shi |
Cell Death and Differentiation | 2013 |
Cytokine targets in airway inflammation
MJ Schuijs, MA Willart, H Hammad, BN Lambrecht |
Current Opinion in Pharmacology | 2013 |
Key Regulators of Sensitization and Tolerance: GM-CSF, IL-10, TGF-β and the Notch Signaling Pathway in Adjuvant-Free Experimental Models of Respiratory Allergy
GV Guibas, M Makris, NG Papadopoulos |
International Reviews of Immunology | 2013 |
Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells(⋆)
L Xue, M Salimi, I Panse, JM Mjösberg, AN McKenzie, H Spits, P Klenerman, G Ogg |
Journal of Allergy and Clinical Immunology | 2013 |
Asthma: The importance of dysregulated barrier immunity: HIGHLIGHTS
BN Lambrecht, H Hammad |
European Journal of Immunology | 2013 |
Neutralization of TSLP Inhibits Airway Remodeling in a Murine Model of Allergic Asthma Induced by Chronic Exposure to House Dust Mite
ZG Chen, TT Zhang, HT Li, FH Chen, XL Zou, JZ Ji, H Chen, B Ryffel |
PloS one | 2013 |
Cellular networks controlling Th2 polarization in allergy and immunity
M Kool, H Hammad, BN Lambrecht |
F1000 biology reports | 2012 |
Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
MA Willart, K Deswarte, P Pouliot, H Braun, R Beyaert, BN Lambrecht, H Hammad |
Journal of Experimental Medicine | 2012 |
The airway epithelium in asthma
BN Lambrecht, H Hammad |
Nature Medicine | 2012 |
Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma
L Ramakrishna, VC de Vries, MA de Lafaille |
Immunologic Research | 2012 |
Alternaria Fungus Induces the Production of GM-CSF, Interleukin-6 and Interleukin-8 and Calcium Signaling in Human Airway Epithelium through Protease-Activated Receptor 2
Y Matsuwaki, K Wada, T White, H Moriyama, H Kita |
International Archives of Allergy and Immunology | 2012 |
Comparison of WTC Dust Size on Macrophage Inflammatory Cytokine Release In vivo and In vitro
MD Weiden, B Naveed, S Kwon, LN Segal, SJ Cho, J Tsukiji, R Kulkarni, AL Comfort, KJ Kasturiarachchi, C Prophete, MD Cohen, LC Chen, WN Rom, DJ Prezant, A Nolan |
PloS one | 2012 |
Biological Therapies in Development for COPD
J Morjaria, R Polosa |
Advances in Combination Therapy for Asthma and COPD Lötvall/Advances in Combination Therapy for Asthma and COPD | 2012 |
Small Interfering RNA Targeting T-cell Ig Mucin-3 Decreases Allergic Airway Inflammation and Hyperresponsiveness
XX Lu, KS McCoy, JL Xu, WK Hu, HB Chen |
Inflammation | 2012 |
L’épithélium pulmonaire contrôle la sensibilisation allergique initiée par les cellules dendritiques
H Hammad |
Revue Française d'Allergologie | 2012 |
Th2 cytokine antagonists: potential treatments for severe asthma
PM Hansbro, GV Scott, AT Essilfie, RY Kim, MR Starkey, DH Nguyen, PD Allen, GE Kaiko, M Yang, JC Horvat, PS Foster |
Expert Opinion on Investigational Drugs | 2012 |
Exposure of immunologically naive laboratory rodents to antigen via the airways. Where does tolerance stop and sensitization begin?
GV Guibas, M Makris, E Spandou, KN Priftis |
Clinical & Experimental Allergy | 2012 |
Comparison of WTC Dust Size on Macrophage Inflammatory Cytokine Release In vivo and In vitro
MD Weiden, B Naveed, S Kwon, LN Segal, SJ Cho, J Tsukiji, R Kulkarni, AL Comfort, KJ Kasturiarachchi, C Prophete, MD Cohen, LC Chen, WN Rom, DJ Prezant, A Nolan, J Sturtevant |
PloS one | 2012 |
Cytokine/anti-cytokine therapy – novel treatments for asthma?
PM Hansbro, GE Kaiko, PS Foster |
British Journal of Pharmacology | 2011 |
Inflammation and Allergy Drug Design
K Arima, YJ Liu |
Inflammation and Allergy Drug Design | 2011 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance
CS Stevenson, MA Birrell |
Pharmacology & Therapeutics | 2011 |
Airway exposure to hypochlorite prior to ovalbumin induces airway hyperreactivity without evidence for allergic sensitization
V Hox, JA Vanoirbeek, I Callebaut, S Bobic, VD Vooght, J Ceuppens, P Hoet, B Nemery, PW Hellings |
Toxicology Letters | 2011 |
Emerging role of innate immunity in organ transplantation part III: the quest for transplant tolerance via prevention of oxidative allograft injury and its consequences
WG Land |
Transplantation Reviews | 2011 |
Lung dendritic cell–epithelial cell crosstalk in Th2 responses to allergens
M Willart, H Hammad |
Current Opinion in Immunology | 2011 |
Allergens and respiratory pollutants
KF Chung, AS Williams |
Allergens and respiratory pollutants | 2011 |
Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma
LI Ionescu, RS Alphonse, N Arizmendi, B Morgan, M Abel, F Eaton, M Duszyk, H Vliagoftis, TR Aprahamian, K Walsh, B Thébaud |
American journal of respiratory cell and molecular biology | 2011 |
German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment
SB Day, JR Ledford, P Zhou, IP Lewkowich, K Page |
Journal of Innate Immunity | 2011 |
Methods in Molecular Biology
P Pouliot, MA Willart, H Hammad, BN Lambrecht |
Methods in molecular biology (Clifton, N.J.) | 2010 |
Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25
LG Gregory, SA Mathie, SA Walker, S Pegorier, CP Jones, CM Lloyd |
American journal of respiratory and critical care medicine | 2010 |
Progress in Understanding Postnatal Immune Dysregulation in Allergic Disease
SL Prescott, D Martino, M Hodder, T Richman, MK Tulic |
World Allergy Organization Journal | 2010 |
T-cell polarization depends on concentration of the danger signal used to activate dendritic cells
M Peters, K Dudziak, M Stiehm, A Bufe |
Immunology and Cell Biology | 2010 |
The role of dendritic and epithelial cells as master regulators of allergic airway inflammation
BN Lambrecht, H Hammad |
The Lancet | 2010 |
Alarming Dendritic Cells for Allergic Sensitization
MA Willart, H Hammad |
Allergology International | 2010 |
Airway Epithelial NF-κB Activation Promotes Allergic Sensitization to an Innocuous Inhaled Antigen
JL Ather, SR Hodgkins, YM Janssen-Heininger, ME Poynter |
American journal of respiratory cell and molecular biology | 2010 |
Improving Adenovirus Based Gene Transfer: Strategies to Accomplish Immune Evasion
SS Seregin, A Amalfitano |
Viruses | 2010 |
Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation
R Vlahos, S Bozinovski, SP Chan, S Ivanov, A Lindén, JA Hamilton, GP Anderson |
American journal of respiratory and critical care medicine | 2010 |
Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients
WT Loo, LJ Jin, LW Chow, MN Cheung, M Wang |
Expert Opinion on Investigational Drugs | 2010 |
Fas-Activated Serine/Threonine Phosphoprotein Promotes Immune-Mediated Pulmonary Inflammation
M Simarro, G Giannattasio, MA la Fuente, C Benarafa, KK Subramanian, R Ishizawar, B Balestrieri, EM Andersson, HR Luo, A Orduña, J Boyce, P Anderson |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Differential effects of dendritic cell transfer on airway hyperresponsiveness and inflammation
T Koya, H Matsuda, S Matsubara, N Miyahara, A Dakhama, K Takeda, EW Gelfand |
American journal of respiratory cell and molecular biology | 2009 |
Dendritic Cells
G Lombardi, Y Riffo-Vasquez |
Dendritic Cells | 2009 |
Dendritic Cells
G Lombardi, Y Riffo-Vasquez |
Dendritic Cells | 2009 |
Dendritic Cells
G Lombardi, Y Riffo-Vasquez |
Dendritic Cells | 2009 |
House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
H Hammad, M Chieppa, F Perros, MA Willart, RN Germain, BN Lambrecht |
Nature Medicine | 2009 |
Concomitant Inhalation of Cigarette Smoke and Aerosolized Protein Activates Airway Dendritic Cells and Induces Allergic Airway Inflammation in a TLR-Independent Way
LJ Robays, EA Lanckacker, KB Moerloose, T Maes, KR Bracke, GG Brusselle, GF Joos, KY Vermaelen |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke
S Halappanavar, M Russell, MR Stampfli, A Williams, CL Yauk |
BMC Medical Genomics | 2009 |
Between a cough and a wheeze: dendritic cells at the nexus of tobacco smoke-induced allergic airway sensitization
LJ Robays, T Maes, GF Joos, KY Vermaelen |
Mucosal Immunology | 2009 |
Dendritic Cells
S Pai, R Thomas |
Rheumatoid Arthritis | 2009 |
Asthma and COPD
SA Shore, SD Shapiro |
Asthma and COPD | 2009 |
Growth Factors
M Kolb, Z Xing, K Ask, J Gauldie |
Asthma and COPD | 2009 |
Allergy Frontiers: Epigenetics, Allergens and Risk Factors
R Pawankar, ST Holgate, LJ Rosenwasser |
2009 | |
Induction of IL-10 producing CD4+ T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells
CL Fu, YH Chuang, HY Huang, BL Chiang |
Clinical & Experimental Immunology | 2008 |
Granulocyte-Macrophage Colony-Stimulating Factor Is Required for Bronchial Eosinophilia in a Murine Model of Allergic Airway Inflammation
YC Su, MS Rolph, NG Hansbro, CR Mackay, WA Sewell |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Respiratory syncytial virus infection provokes airway remodelling in allergen–exposed mice in absence of prior allergen sensitization
S Tourdot, S Mathie, T Hussell, L Edwards, H Wang, PJ Openshaw, J Schwarze, CM Lloyd |
Clinical & Experimental Allergy | 2008 |
CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
BD Medoff, AL Landry, KA Wittbold, BP Sandall, MC Derby, Z Cao, JC Adams, RJ Xavier |
American journal of respiratory cell and molecular biology | 2008 |
Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization
S Tourdot, S Mathie, T Hussell, L Edwards, H Wang, PJ Openshaw, J Schwarze, CM Lloyd |
Clinical & Experimental Allergy | 2008 |
In vivo-to-in silico iterations to investigate aeroallergen-host interactions
A Llop-Guevara, M Colangelo, DK Chu, CL Moore, NA Stieber, TD Walker, S Goncharova, AJ Coyle, LK Lundblad, PM O'Byrne, M Lovric, M Jordana |
PloS one | 2008 |
Immunomodulatory Effects of CpG Oligodeoxynucleotides on House Dust Mite-Induced Airway Inflammation in Mice
I Hirose, H Tanaka, G Takahashi, K Wakahara, M Tamari, T Sakamoto, S Kojima, N Inagaki, H Nagai |
International Archives of Allergy and Immunology | 2008 |
Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
H Hammad, BN Lambrecht |
Nature Reviews Immunology | 2008 |
Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity
C Haar, M Kool, I Hassing, M Bol, BN Lambrecht, R Pieters |
Journal of Allergy and Clinical Immunology | 2008 |
Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice
E Koike, H Takano, K Inoue, R Yanagisawa |
International Immunopharmacology | 2008 |
Induction of Vascular Remodeling in the Lung by Chronic House Dust Mite Exposure
K Rydell-Törmänen, JR Johnson, R Fattouh, M Jordana, JS Erjefält |
American journal of respiratory cell and molecular biology | 2008 |
In Vivo-to-In Silico Iterations to Investigate Aeroallergen-Host Interactions
A Llop-Guevara, M Colangelo, DK Chu, CL Moore, NA Stieber, TD Walker, S Goncharova, AJ Coyle, LK Lundblad, PM O'Byrne, M Lovric, M Jordana, J Zimmer |
PloS one | 2008 |
Combined budesonide/formoterol therapy in conjunction with allergen avoidance ameliorates house dust mite-induced airway remodeling and dysfunction
JR Johnson, SR Pacitto, J Wong, EW Archer, S Eirefelt, A Miller-Larsson, M Jordana |
American journal of physiology. Lung cellular and molecular physiology | 2008 |
Lipoxin A 4 Counterregulates GM-CSF Signaling in Eosinophilic Granulocytes
V Starosta, K Pazdrak, I Boldogh, T Svider, A Kurosky |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans
G Rajagopalan, AK Mangalam, MM Sen, S Cheng, YC Kudva, CS David |
Autoimmunity | 2007 |
Th2 Differentiation in Distinct Lymph Nodes Influences the Site of Mucosal Th2 Immune-Inflammatory Responses
D Alvarez, JL Arkinson, J Sun, R Fattouh, T Walker, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
LUNG DENDRITIC CELLS: FROM BASIC PHYSIOLOGY TO CLINICAL APPLICATIONS
BN Lambrecht |
ACTA CLINICA BELGICA | 2007 |
Proteases and Protease-activated receptors signalling: at the crossroads of acquired and innate immunity
MB Hershenson |
Clinical & Experimental Allergy | 2007 |
Components of airway hyperresponsiveness and their associations with inflammation and remodeling in mice
DS Southam, R Ellis, J Wattie, MD Inman |
Journal of Allergy and Clinical Immunology | 2007 |
Building Better Mouse Models of Asthma
CM Lloyd |
Current Allergy and Asthma Reports | 2007 |
Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes
JR Johnson, FK Swirski, BU Gajewska, RE Wiley, R Fattouh, SR Pacitto, JK Wong, MR Stämpfli, M Jordana |
American journal of physiology. Lung cellular and molecular physiology | 2007 |
Eosinophilia is induced in the colon of Th2-sensitized mice upon exposure to locally expressed antigen
Q Zhu, CW Thomson, G Zhang, M Stämpfli, MR McDermott, SM Collins, J Gauldie |
AJP Gastrointestinal and Liver Physiology | 2007 |
Local CD11c+ MHC class II- precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process
H Wang, N Peters, V Laza-Stanca, N Nawroly, SL Johnston, J Schwarze |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues
D Alvarez, FK Swirski, TC Yang, R Fattouh, K Croitoru, JL Bramson, MR Stämpfli, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Generation and characterization of B7-H4/B7S1/B7x-deficient mice
WK Suh, S Wang, GS Duncan, Y Miyazaki, E Cates, T Walker, BU Gajewska, E Deenick, W Dawicki, H Okada, A Wakeham, A Itie, TH Watts, PS Ohashi, M Jordana, H Yoshida, TW Mak |
Molecular and cellular biology | 2006 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
Y Shi, CH Liu, AI Roberts, J Das, G Xu, G Ren, Y Zhang, L Zhang, ZR Yuan, HS Tan, G Das, S Devadas |
Cell Research | 2006 |
Mouse models of asthma and rhinitis to study the role of dendritic cells in sensitization and development of inflammation
BN Lambrecht, A Kleinjan |
Drug Discovery Today: Disease Models | 2006 |
Cigarette smoke exposure facilitates allergic sensitization in mice
KB Moerloose, LJ Robays, T Maes, GG Brusselle, KG Tournoy, GF Joos |
Respiratory Research | 2006 |
Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF)
R Vlahos, S Bozinovski, JA Hamilton, GP Anderson |
Pharmacology & Therapeutics | 2006 |
Prolonged Ovalbumin Exposure Attenuates Airway Hyperresponsiveness and T Cell Function in Mice
FK Swirski, A D’Sa, S Kianpour, MD Inman, MR Stämpfli |
International Archives of Allergy and Immunology | 2006 |
The development of respiratory inflammation in children
SL Prescott |
Paediatric Respiratory Reviews | 2006 |
Mechanisms of Chlamydophila pneumoniae –Mediated GM-CSF Release in Human Bronchial Epithelial Cells
M Krüll, P Bockstaller, FN Wuppermann, AC Klucken, J Mühling, B Schmeck, J Seybold, C Walter, M Maass, S Rosseau, JH Hegemann, N Suttorp, S Hippenstiel |
American journal of respiratory cell and molecular biology | 2006 |
Diesel Exhaust Particle-Exposed Human Bronchial Epithelial Cells Induce Dendritic Cell Maturation
B Bleck, DB Tse, I Jaspers, MA de Lafaille, J Reibman |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Effect of Different Forms of Adenylate Cyclase Toxin of Bordetella pertussis on Protection Afforded by an Acellular Pertussis Vaccine in a Murine Model
GY Cheung, D Xing, S Prior, MJ Corbel, R Parton, JG Coote |
Infection and immunity | 2006 |
In vivo depletion of lung CD11c + dendritic cells during allergen challenge abrogates the characteristic features of asthma
LS van Rijt, S Jung, A KleinJan, N Vos, M Willart, C Duez, HC Hoogsteden, BN Lambrecht |
Journal of Experimental Medicine | 2005 |
Blockade of CTLA-4 Promotes Airway Inflammation in Naive Mice Exposed to Aerosolized Allergen but Fails to Prevent Inhalation Tolerance
L Alenmyr, V Matheu, L Uller, L Greiff, M Malm-Erjefalt, HG Ljunggren, CG Persson, M Korsgren |
Scandinavian Journal of Immunology | 2005 |
Immune responses and disease enhancement during respiratory syncytial virus infection
PJ Openshaw, JS Tregoning |
Clinical microbiology reviews | 2005 |
Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid β-protein and GM-CSF
HD Kim, Y Cao, FK Kong, KR van Kampen, TL Lewis, Z Ma, DC Tang, KI Fukuchi |
Vaccine | 2005 |
Dendritic cells and the regulation of the allergic immune response
BN Lambrecht |
Allergy | 2005 |
Immune dysregulation in allergic respiratory disease: the role of T regulatory cells
SL Prescott, JA Dunstan |
Pulmonary Pharmacology & Therapeutics | 2005 |
Co-vaccination with adeno-associated virus vectors encoding human papillomavirus 16 L1 proteins and adenovirus encoding murine GM-CSF can elicit strong and prolonged neutralizing antibody
DW Liu, JL Chang, YP Tsao, CW Huang, SW Kuo, SL Chen |
International Journal of Cancer | 2005 |
Reversing the Autoimmune Condition: Experience with Experimental Autoimmune Gastritis
F Alderuccio, K Murphy, M Biondo, J Field, BH Toh |
International Reviews of Immunology | 2005 |
Mucosal Immunology
WR Brown |
Mucosal Immunology | 2005 |
Pulmonary Dendritic Cells
K Vermaelen, R Pauwels |
American journal of respiratory and critical care medicine | 2005 |
Comparison of asthma phenotypes using different sensitizing protocols in mice
YS Chang, YK Kim, JW Bahn, SH Kim, HW Park, TB Kim, SH Cho, KU Min, YY Kim |
The Korean Journal of Internal Medicine | 2005 |
House Dust Mite Facilitates Ovalbumin-specific Allergic Sensitization and Airway Inflammation
R Fattouh, MA Pouladi, D Alvarez, JR Johnson, TD Walker, S Goncharova, MD Inman, M Jordana |
American journal of respiratory and critical care medicine | 2005 |
Comparison of Asthma Phenotypes Using Different Sensitizing Protocols in Mice
YS Chang, YK Kim, JW Bahn, SH Kim, HW Park, TB Kim, SH Cho, KU Min, YY Kim |
The Korean Journal of Internal Medicine | 2005 |
Cutaneous Antigen Priming via Gene Gun Leads to Skin-Selective Th2 Immune-Inflammatory Responses
D Alvarez, G Harder, R Fattouh, J Sun, S Goncharova, MR Stämpfli, AJ Coyle, JL Bramson, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Mainstream Cigarette Smoke Exposure Attenuates Airway Immune Inflammatory Responses to Surrogate and Common Environmental Allergens in Mice, Despite Evidence of Increased Systemic Sensitization
CS Robbins, MA Pouladi, R Fattouh, DE Dawe, N Vujicic, CD Richards, M Jordana, MD Inman, MR Stampfli |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
B7RP-1 Is Not Required for the Generation of Th2 Responses in a Model of Allergic Airway Inflammation but Is Essential for the Induction of Inhalation Tolerance
BU Gajewska, A Tafuri, FK Świrski, T Walker, JR Johnson, T Shea, A Shahinian, S Goncharova, TW Mak, MR Stämpfli, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Transient corticosteroid treatment permanently amplifies the Th2 response in a murine model of asthma
RE Wiley, M Cwiartka, D Alvarez, DC Mackenzie, JR Johnson, S Goncharova, L Lundblad, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody
S Radhakrishnan, K Iijima, T Kobayashi, M Rodriguez, H Kita, LR Pease |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism
EC Cates, R Fattouh, J Wattie, MD Inman, S Goncharova, AJ Coyle, JC Gutierrez-Ramos, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
HJ de Heer, H Hammad, T Soullié, D Hijdra, N Vos, MA Willart, HC Hoogsteden, BN Lambrecht |
Journal of Experimental Medicine | 2004 |
The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo
SA Ritz, MJ Cundall, BU Gajewska, FK Swirski, RE Wiley, D Alvarez, AJ Coyle, MR Stampfli, M Jordana |
Clinical & Experimental Immunology | 2004 |
Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by flow cytometry: Methodology and new insights
K Vermaelen, R Pauwels |
Cytometry | 2004 |
Role of dendritic cells in Th1/Th2 balance: A novel therapeutic target of allergic diseases
Y Ohshima, M Yasutomi, N Omata, M Mayumi |
Allergology International | 2004 |
The role of dendritic cells in asthma
PG Holt, JW Upham |
Current Opinion in Allergy and Clinical Immunology | 2004 |
Vitamin D Receptor-Deficient Mice Fail to Develop Experimental Allergic Asthma
A Wittke, V Weaver, BD Mahon, A August, MT Cantorna |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Taking our breath away: dendritic cells in the pathogenesis of asthma
BN Lambrecht, H Hammad |
Nature Reviews Immunology | 2003 |
Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract
PA Stumbles, JW Upham, PG Holt |
APMIS | 2003 |
The role of dendritic cells in immune regulation and allergic airway inflammation
JW UPHAM |
Respirology | 2003 |
Why are dendritic cells important in allergic diseases of the respiratory tract?
JW Upham, PA Stumbles |
Pharmacology & Therapeutics | 2003 |
Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization
EC Cates, BU Gajewska, S Goncharova, D Alvarez, R Fattouh, AJ Coyle, JC Gutierrez-Ramos, M Jordana |
Journal of Allergy and Clinical Immunology | 2003 |
Lung Biology in Health and Disease
N Zamel |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2003 |
Ribavirin or CpG DNA Sequence–Modulated Dendritic Cells Decrease the IgE Level and Airway Inflammation
DJ Chiang, YL Ye, WL Chen, YL Lee, NY Hsu, BL Chiang |
American journal of respiratory and critical care medicine | 2003 |
Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma: DC Activation Occurs in the Airway Mucosa but Not in the Lung Parenchyma
JC Huh, DH Strickland, FL Jahnsen, DJ Turner, JA Thomas, S Napoli, I Tobagus, PA Stumbles, PD Sly, PG Holt |
Journal of Experimental Medicine | 2003 |
The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses
WK Suh, BU Gajewska, H Okada, MA Gronski, EM Bertram, W Dawicki, GS Duncan, J Bukczynski, S Plyte, A Elia, A Wakeham, A Itie, S Chung, JD Costa, S Arya, T Horan, P Campbell, K Gaida, PS Ohashi, TH Watts, SK Yoshinaga, MR Bray, M Jordana, TW Mak |
Nature Immunology | 2003 |
Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4
SA Ritz, MJ Cundall, BU Gajewska, D Alvarez, JC Gutierrez-Ramos, AJ Coyle, AN McKenzie, MR Stämpfli, M Jordana |
American journal of respiratory cell and molecular biology | 2002 |
GM-CSF transgene-based adjuvant allows the establishment of protective mucosal immunity following vaccination with inactivated Chlamydia trachomatis
H Lu, Z Xing, RC Brunham |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling
AK Behera, M Kumar, RF Lockey, SS Mohapatra |
Human Gene Therapy | 2002 |
Chronic Exposure to Innocuous Antigen in Sensitized Mice Leads to Suppressed Airway Eosinophilia That Is Reversed by Granulocyte Macrophage Colony-Stimulating Factor
FK Swirski, D Sajic, CS Robbins, BU Gajewska, M Jordana, MR Stämpfli |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Diesel Particles Are Taken Up by Alveolar Type II Tumor Cells and Alter Cytokines Secretion
P Juvin, T Fournier, S Boland, P Soler, F Marano, JM Desmonts, M Aubier |
Archives of Environmental Health: An International Journal | 2002 |
Attenuation of airway hyperresponsiveness in a murine asthma model by neutralization of granulocyte–macrophage colony-stimulating factor (GM-CSF)
N Yamashita, H Tashimo, H Ishida, F Kaneko, J Nakano, H Kato, K Hirai, T Horiuchi, K Ohta |
Cellular Immunology | 2002 |
Effect of ozone exposure on allergic sensitization and airway inflammation induced by dendritic cells
PO Depuydt, BN Lambrecht, GF Joos, RA Pauwels |
Clinical & Experimental Allergy | 2002 |
On the generation of allergic airway diseases: from GM-CSF to Kyoto
SA Ritz, MR Stämpfli, DE Davies, ST Holgate, M Jordana |
Trends in Immunology | 2002 |
The Role of Airway Dendritic Cell Populations in Regulation of T-Cell Responses to Inhaled Antigens: Atopic Asthma as a Paradigm
PG Holt |
Journal of Aerosol Medicine | 2002 |
Hypersensitivity reactions after respiratory sensitization: Effect of intranasal peptides containing T-cell epitopes
AG Jarnicki, T Tsuji, WR Thomas |
Journal of Allergy and Clinical Immunology | 2002 |
Perivascular capillaries in the lung: An important but neglected vascular bed in immune reactions?
R Pabst, T Tschernig |
Journal of Allergy and Clinical Immunology | 2002 |
Comparison of effects of anti-IL-3, IL-5 and GM-CSF treatments on eosinophilopoiesis and airway eosinophilia induced by allergen
M Tomaki, LL Zhao, M Sjöstrand, A Lindén, M Ichinose, J Lötvall |
Pulmonary Pharmacology & Therapeutics | 2002 |
Gene Therapy in Lung Disease
K Amin |
Gene Therapy in Lung Disease | 2002 |
Size Fractions of Ambient Particulate Matter Induce Granulocyte Macrophage Colony–Stimulating Factor in Human Bronchial Epithelial Cells by Mitogen-Activated Protein Kinase Pathways
J Reibman, Y Hsu, LC Chen, A Kumar, WC Su, W Choy, A Talbot, T Gordon |
American journal of respiratory cell and molecular biology | 2002 |
Bacterial Stimulation of Epithelial G-CSF and GM-CSF Expression Promotes PMN Survival in CF Airways
S Saba, G Soong, S Greenberg, A Prince |
American journal of respiratory cell and molecular biology | 2002 |
Mice Are Not a Good Model of Human Airway Disease
CG Persson |
American journal of respiratory and critical care medicine | 2002 |
Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine: Role of dendritic cells
P Ou-Yang, LH Hwang, MH Tao, BL Chiang, DS Chen |
Journal of Medical Virology | 2002 |
Ectopic expression of IL-5 identifies an additional CD4 + T cell mechanism of airway eosinophil recruitment
JR Crosby, HH Shen, MT Borchers, JP Justice, T Ansay, JJ Lee, NA Lee |
American journal of physiology. Lung cellular and molecular physiology | 2002 |
G q Signaling Is Required for Allergen-Induced Pulmonary Eosinophilia
MT Borchers, PJ Justice, T Ansay, V Mancino, MP McGarry, J Crosby, MI Simon, NA Lee, JJ Lee |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Generation of experimental allergic airways inflammation in the absence of draining lymph nodes
Beata U. Gajewska, David Alvarez, Mariana Vidric, Susanna Goncharova, Martin R. Stämpfli, Anthony J. Coyle, José-Carlos Gutierrez-Ramos, Manel Jordana |
Journal of Clinical Investigation | 2001 |
Secondhand smoke induces allergic sensitization in mice
R Rumold, M Jyrala, D Diaz-Sanchez |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Role of dendritic cells and Th2 lymphocytes in asthma: Lessons from eosinophilic airway inflammation in the mouse
LS van Rijt, BN Lambrecht |
Microscopy Research and Technique | 2001 |
The dendritic cell in allergic airway diseases: a new player to the game
BN Lambrecht |
Clinical & Experimental Allergy | 2001 |
Structural and Functional Hot Spots in Cytokine Receptors
CJ Bagley, JM Woodcock, MA Guthridge, FC Stomski, AF Lopez |
International Journal of Hematology | 2001 |
Peribronchiolar accumulation of dendritic cells and their close association with CD4+ T cells in the murine lung hypersensitivity
T Nishida, K Inoue, Y Kawata, H Suzuki, H Kinoshita, K Kaneda |
Microscopy Research and Technique | 2001 |
Dendritic cells as sentinel cells in asthma
PG Holt |
Clinical & Experimental Allergy Reviews | 2001 |
Monocytes and macrophages - friend or foe?
C Hawrylowicz, J Caulfield, M Fernandez, D Richards, A Sousa, S Lane, TK Loke, R Lo, C Corrigan, B O'Connor, T Lee |
Clinical & Experimental Allergy Reviews | 2001 |
Recruitment of CD1a+ Langerhans cells to the nasal mucosa in seasonal allergic rhinitis and effects of topical corticosteroid therapy
SJ Till, MR Jacobson, F O'Brien, SR Durham, A KleinJan, WJ Fokkens, S Juliusson, O Lowhagen |
Allergy | 2001 |
Allergen uptake and presentation by dendritic cells
BN Lambrecht |
Current Opinion in Allergy and Clinical Immunology | 2001 |
El asma. Siete preguntas actuales
JS Aldás |
Revista Clínica Española | 2001 |
Budesonide Enhances Repeated Gene Transfer and Expression in the Lung with Adenoviral Vectors
M Kolb, M Inman, PJ Margetts, T Galt, J Gauldie |
American journal of respiratory and critical care medicine | 2001 |
Inhibition of mucosal and systemic Th2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1
AG Jarnicki, T Tsuji, WR Thomas |
International Immunology | 2001 |
Expression of the Th1 Chemokine IFN-γ-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice
RE Wiley, K Palmer, BU Gajewska, MR Stämpfli, D Alvarez, AJ Coyle, JC Gutierrez-Ramos, M Jordana |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Inducible Expression of Inflammatory Chemokines in Respiratory Syncytial Virus-Infected Mice: Role of MIP-1α in Lung Pathology
HA Haeberle, WA Kuziel, HJ Dieterich, A Casola, Z Gatalica, RP Garofalo |
Journal of virology | 2001 |
Local Transgenic Expression of Granulocyte Macrophage-Colony Stimulating Factor Initiates Autoimmunity
M Biondo, Z Nasa, A Marshall, BH Toh, F Alderuccio |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Sensitization to inhaled antigen by intratracheal instillation of dendritic cells
Lambrecht, Peleman, Bullock, Pauwels |
Clinical & Experimental Allergy | 2000 |
Characterization of Dendritic Cell Populations in the Respiratory Tract
P Holt, P Stumbles |
Journal of Aerosol Medicine | 2000 |
Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm
PG Holt, PA Stumbles |
Journal of Allergy and Clinical Immunology | 2000 |
Determinants of the immune-inflammatory response in allergic airway inflammation: Overview of antigen presentation and cellular activation
SA Ritz, BU Gajewska, MR Stämpfli, M Jordana |
Journal of Allergy and Clinical Immunology | 2000 |
Antigen Presentation in the Lung
PG Holt |
American journal of respiratory and critical care medicine | 2000 |
The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity
AW Mould, AJ Ramsay, KI Matthaei, IG Young, ME Rothenberg, PS Foster |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung
J Wang, DP Snider, BR Hewlett, NW Lukacs, J Gauldie, H Liang, Z Xing |
Blood | 2000 |
Regulation of Expression of Granulocyte-Macrophage Colony-Stimulating Factor in Human Bronchial Epithelial Cells: Roles of Protein Kinase C and Mitogen-Activated Protein Kinases
J Reibman, AT Talbot, Y Hsu, G Ou, J Jover, D Nilsen, MH Pillinger |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
The Timing of GM-CSF Expression Plasmid Administration Influences the Th1/Th2 Response Induced by an HIV-1-Specific DNA Vaccine
K Kusakabe, KQ Xin, H Katoh, K Sumino, E Hagiwara, S Kawamoto, K Okuda, Y Miyagi, I Aoki, K Nishioka, D Klinman, K Okuda |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids
JJ Caulfield, MH Fernandez, AR Sousa, SJ Lane, TH Lee, CM Hawrylowicz |
Immunology | 1999 |
Basic mechanisms and clinical implications of oral tolerance
AM Mowat |
Current Opinion in Gastroenterology | 1999 |
Antigen-presenting cells in nasal allergy
WJ Fokkens |
Allergy | 1999 |
Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice
MR Stämpfli, M Cwiartka, BU Gajewska, D Alvarez, SA Ritz, MD Inman, Z Xing, M Jordana |
American journal of respiratory cell and molecular biology | 1999 |
Regulation of allergic mucosal sensitization by interleukin-12 gene transfer to the airway
MR Stämpfli, GS Neigh, RE Wiley, M Cwiartka, SA Ritz, MM Hitt, Z Xing, M Jordana |
American journal of respiratory cell and molecular biology | 1999 |
The Macroimportance of the Pulmonary Immune Microenvironment
NA Lee, JJ Lee |
American journal of respiratory cell and molecular biology | 1999 |
Simultaneous Antagonism of Interleukin-5, Granulocyte-Macrophage Colony-Stimulating Factor, and Interleukin-3 Stimulation of Human Eosinophils by Targetting the Common Cytokine Binding Site of Their Receptors
Q Sun, K Jones, B McClure, B Cambareri, B Zacharakis, PO Iversen, F Stomski, JM Woodcock, CJ Bagley, R DAndrea, AF Lopez |
Blood | 1999 |