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Citations to this article

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.
S B Liggett, … , T C McIntosh, R A Walsh
S B Liggett, … , T C McIntosh, R A Walsh
Published October 15, 1998
Citation Information: J Clin Invest. 1998;102(8):1534-1539. https://doi.org/10.1172/JCI4059.
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The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.

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Abstract

The beta2-adrenergic receptor (beta2AR), an important modulator of cardiac inotropy and chronotropy, has significant genetic heterogeneity in the population. Because dysfunctional betaARs play a role in the pathogenesis of the failing ventricle, we tested the hypothesis that beta2AR polymorphisms alter the outcome of congestive heart failure. 259 patients with NYHA functional class II-IV heart failure due to ischemic or dilated cardiomyopathy were genotyped and prospectively followed, with the endpoint defined as death or cardiac transplantation. The allele frequencies between this group and those of 212 healthy controls also were compared and did not differ between the groups. However, those with the Ile164 polymorphism displayed a striking difference in survival with a relative risk of death or cardiac transplant of 4.81 (P < 0.001) compared with those with the wild-type Thr at this position. Age, race, gender, functional class, etiology, ejection fraction, and medication use did not differ between these individuals and those with the wild-type beta2AR, and thus the beta2AR genotype at position 164 was the only clear distinguishing feature between the two groups. The 1-yr survival for Ile164 patients was 42% compared with 76% for patients harboring wild-type beta2AR. In contrast, polymorphisms at amino acid positions 16 (Arg or Gly) or 27 (Gln or Glu), which also alter receptor phenotype, did not appear to have an influence on the course of heart failure. Taken together with cell-based and transgenic mouse results, this study establishes a paradigm whereby genetic variants of key signaling elements can have pathophysiologic consequences within the context of a disease. Furthermore, patients with the Ile164 polymorphism and heart failure may be candidates for earlier aggressive intervention or cardiac transplantation.

Authors

S B Liggett, L E Wagoner, L L Craft, R W Hornung, B D Hoit, T C McIntosh, R A Walsh

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Pharmacogenetics of the human beta-adrenergic receptors
MR Taylor
The Pharmacogenomics Journal 2006
Impact of β2-adrenoreceptor gene variants on cardiac cavity size and systolic function in idiopathic dilated cardiomyopathy
D Badenhorst, GR Norton, K Sliwa, R Brooksbank, R Essop, P Sareli, AJ Woodiwiss
The Pharmacogenomics Journal 2006
??2-Adrenoceptor Genotype Affects Vasopressor Requirements during Spinal Anesthesia for Cesarean Delivery
RM Smiley, JL Blouin, M Negron, R Landau
Anesthesiology 2006
Pharmacological treatment of chronic heart failure
R Adorisio, LD Luca, J Rossi, M Gheorghiade
Heart Failure Reviews 2006
Is there a role of the Thr164Ile-β2-adrenoceptor polymorphism for the outcome of chronic heart failure?
K Leineweber, G Tenderich, C Wolf, S Wagner, A Zittermann, M Elter-Schulz, R Moog, N Müller, HG Jakob, R Körfer, T Philipp, G Heusch, OE Brodde
Basic Research in Cardiology 2006
Genetics in Heart Failure: Where Are We Headed?
RA Boer, MP Berg, DJ Veldhuisen
Congestive Heart Failure 2006
Cardiac implications for the use of β2-adrenoceptor agonists for the management of muscle wasting
P Molenaar, L Chen, WA Parsonage
British Journal of Pharmacology 2006
Pharmacogenetics: The Role of Genetic Variants in Disease Diagnosis and Drug Response
D Cooper, J Cockcroft
Pharmacogenetics 2006
β2-Adrenergic Receptor Genotype and Pulmonary Function in Patients With Heart Failure
EM Snyder, ST Turner, BD Johnson
Chest 2006
Adrenoceptor Polymorphisms and the Risk of Cardiac Injury and Dysfunction After Subarachnoid Hemorrhage
JG Zaroff, L Pawlikowska, JC Miss, S Yarlagadda, C Ha, A Achrol, PY Kwok, CE McCulloch, MT Lawton, N Ko, W Smith, WL Young
Stroke; a journal of cerebral circulation 2006
Neurohumoral activation in heart failure: the role of adrenergic receptors
PC Brum, NP Rolim, AV Bacurau, A Medeiros
Anais da Academia Brasileira de Ciências 2006
The role of adrenergic receptor polymorphisms in heart failure
A Biolo, AS Rosa, NG Mazzotti, S Martins, A Belló-Klein, LE Rohde, N Clausell
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2006
Principles of Molecular Medicine
MS Runge, C Patterson
2006
Cardiac Adrenoceptors: Physiological and Pathophysiological Relevance
OE Brodde, H Bruck, K Leineweber
Journal of Pharmacological Sciences 2006
Cardiac Arrhythmias 2005
A Raviele
2006
Pharmacological treatment of chronic heart failure.
Adorisio R, De Luca L, Rossi J, Gheorghiade M
Heart Failure Reviews 2006
A polymorphism of the endothelial nitric oxide synthase promoter is associated with advanced autonomic imbalance in patients with congestive heart failure
Philip F. Binkley, Enrico Nunziatta, Yiwen Liu-Stratton, Glen Cooke
American Heart Journal 2005
Novel human alpha1a-adrenergic receptor single nucleotide polymorphisms alter receptor biological function
Beilei Lei, Daniel P. Morris, Michael P. Smith, Laura P. Svetkey, Mark F. Newman, Jerome I. Rotter, Thomas A. Buchanan, Stephen M. Beckstrom-Sternberg, Eric D. Green, Debra A. Schwinn
Naunyn-Schmiedeberg's Archives of Pharmacology 2005
The G protein-coupled receptors: Pharmacogenetics and Disease
MD Thompson, WM Burnham, DE Cole
Critical Reviews in Clinical Laboratory Sciences 2005
No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
S Nonen, H Okamoto, M Akino, Y Matsui, Y Fujio, M Yoshiyama, Y Takemoto, J Yoshikawa, J Azuma, A Kitabatake
British Journal of Clinical Pharmacology 2005
Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
M Zheng, W Zhu, Q Han, RP Xiao
Pharmacology & Therapeutics 2005
Pharmacogenetics in drug regulation: promise, potential and pitfalls
RR Shah
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005
164Ile allele in the β2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
AA Sethi, A Tybjærg-Hansen, GB Jensen, BG Nordestgaard
Pharmacogenetics and Genomics 2005
??2-Adrenoceptor gene polymorphisms
OE Brodde, K Leineweber
Pharmacogenetics and Genomics 2005
Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure
P Groote, N Helbecque, N Lamblin, X Hermant, EM Fadden, C Foucher-Hossein, P Amouyel, J Dallongeville, C Bauters
Pharmacogenetics and Genomics 2005
Mucociliary clearance in patients with chronic asthma: Effects of beta2 agonists
E DAVISKAS, SD ANDERSON, J SHAW, S EBERL, JP SEALE, IA YANG, IH YOUNG
Respirology 2005
Mechanistic basis of adverse drugreactions: the perils of inappropriate dose schedules
RR Shah
Expert Opinion on Drug Safety 2005
Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure
DS Feldman, CA Carnes, WT Abraham, MR Bristow
Nature Clinical Practice Cardiovascular Medicine 2005
The cardiac β2-adrenergic signalling a new role for the cPLA2
C Pavoine, N Defer
Cellular Signalling 2005
Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis
CM Tang, A Hoerning, R Büscher, DT OʼConnor, F Ratjen, H Grasemann, PA Insel
Pharmacogenetics and Genomics 2005
Pharmacogenetics: implications for obstetric anesthesia
R Landau
International Journal of Obstetric Anesthesia 2005
Genetic association studies in cardiology
MP Donahue, AS Allen
American Heart Journal 2005
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure
G Iaccarino, E Barbato, E Cipolletta, VD Amicis, KB Margulies, D Leosco, B Trimarco, WJ Koch
European Heart Journal 2005
Pharmacogenomics for Neurohormonal Intervention in Heart Failure
DM McNamara
Heart Failure Clinics 2005
The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure*
P Groote, N Lamblin, N Helbecque, F Mouquet, EM Fadden, X Hermant, P Amouyel, J Dallongeville, C Bauters
European Journal of Heart Failure 2005
Monitoring of cardiac function on the basis of serum troponin I levels in patients with acute leukemia treated with anthracyclines
G Specchia, C Buquicchio, N Pansini, FD Serio, V Liso, D Pastore, G Greco, L Ciuffreda, A Mestice, A Liso
Journal of Laboratory and Clinical Medicine 2005
Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance
R Winker, A Barth, E Valic, R Maier, W Osterode, A Pilger, HW Rdiger
International Archives of Occupational and Environmental Health 2005
Inhaled ??2-Adrenoceptor Agonists: Cardiovascular Safety in Patients with Obstructive Lung Disease
M Cazzola, MG Matera, CF Donner
Drugs 2005
Handbook of Cardiac Anatomy, Physiology, and Devices
PA Iaizzo
2005
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
RP Xiao, W Zhu, M Zheng, K Chakir, R Bond, EG Lakatta, H Cheng
Trends in Pharmacological Sciences 2004
Genetic polymorphisms and heart failure
GS Bleumink, AF Schut, MC Sturkenboom, JW Deckers, CM van Duijn, BH Stricker
Genetics in Medicine 2004
The Emerging Pharmacogenomics of the ?-Adrenergic Receptors
MR Taylor, MR Bristow
Congestive Heart Failure 2004
Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II)
RR Shah
British Journal of Clinical Pharmacology 2004
Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead
DW Nebert, ES Vesell
European Journal of Pharmacology 2004
A Polymorphism of the Gene Encoding AMPD1: Clinical Impact and Proposed Mechanisms in Congestive Heart Failure
PF Binkley, A Auseon, G Cooke
Congestive Heart Failure 2004
??2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo
V Dishy, R Landau, GG Sofowora, HG Xie, RM Smiley, RB Kim, DW Byrne, AJ Wood, CM Stein
Pharmacogenetics 2004
Viral-Based Myocardial Gene Therapy Approaches to Alter Cardiac Function
ML Williams, WJ Koch
Annual Review of Physiology 2004
β2-adrenoceptor polymorphisms: Relation between in vitro and in vivo phenotypes
K Leineweber, OE Brodde
Life Sciences 2004
Pharmacogenomics of adrenoceptors
C Flordellis, H Paris, A Karabinis, A Lymperopoulos
Pharmacogenomics 2004
Interaction between cardiac sympathetic drive and heart rate in heart failure
DM Kaye, B Smirk, S Finch, C Williams, MD Esler
Journal of the American College of Cardiology 2004
β-Adrenoceptor polymorphisms and heart failure
MJ Lohse
Trends in Molecular Medicine 2004
?-Adrenoceptor Blockers as Agonists: Coupling of ?2-Adrenoceptors to Multiple G-Proteins in the Failing Human Heart
SE Harding, H Gong
Congestive Heart Failure 2004
Frequency of compound genotypes associated with β-blocker efficacy in congestive heart failure
DE Lanfear, S Marsh, S Cresci, JA Spertus, HL McLeod
Pharmacogenomics 2004
Genetic predisposition to heart failure
M Pasotti, A Repetto, L Tavazzi, E Arbustini
Medical Clinics of North America 2004
Regulation of cardiac contractility by Rab4-modulated β2-adrenergic receptor recycling
A Odley, HS Hahn, RA Lynch, Y Marreez, H Osinska, J Robbins, GW 2nd
Proceedings of the National Academy of Sciences 2004
Polymorphisms of β-adrenergic receptors in heart failure
SB Liggett
The American Journal of Medicine 2004
Association between chronic heart failure and inhaled β-2-adrenoceptor agonists
DH Au, EM Udris, JR Curtis, MB McDonell, SD Fihn
American Heart Journal 2004
Beta‐adrenergic receptor polymorphism in human cardiovascular disease
K Leineweber
Annals of Medicine 2004
Haplotype Analysis of the β2 Adrenergic Receptor Gene and Risk of Myocardial Infarction in Humans
RY Zee, NR Cook, R Reynolds, S Cheng, PM Ridker
Genetics 2004
The Glu27 allele of the ??2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension:
G Iaccarino, F Lanni, E Cipolletta, V Trimarco, R Izzo, GL Iovino, ND Luca, B Trimarco
Journal of Hypertension 2004
Pharmacogenetic Aspects of Drug-Induced Torsade de Pointes: Potential Tool for Improving Clinical Drug Development and Prescribing
RR Shah
Drug Safety 2004
Cardiovascular Pharmacogenetics
MR Wilkins
2004
beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway
C Pavoine, N Behforouz, C Gauthier, SL Gouvello, F Roudot-Thoraval, CR Martin, A Pawlak, C Feral, N Defer, R Houel, S Magne, A Amadou, D Loisance, P Duvaldestin, F Pecker
Molecular pharmacology 2003
Gender, Ethnicity and Genetics in Cardiovascular Disease
BM Schaefer, V Caracciolo, WH Frishman, P Charney
Heart Disease 2003
Targeting signaling pathways in heart failure by gene transfer
BD MacNeill, M Hayase, RJ Hajjar
Current Atherosclerosis Reports 2003
The emerging role of pharmacogenomics in the treatment of patients with heart failure
AM Feldman
The Annals of Thoracic Surgery 2003
PHARMACOLOGY ANDPHYSIOLOGY OFHUMANADRENERGICRECEPTORPOLYMORPHISMS
KM Small, DW McGraw, SB Liggett
Annual Review of Pharmacology and Toxicology 2003
Emerging therapeutic targets in chronic heart failure: Part II
V Roenicke, S Leclair, A Hoffmann, M Becker, T Szado, T Kirsch, O Stoss, BT Navé, T Henkel
Expert Opinion on Therapeutic Targets 2003
Polymorphisms of Adrenergic Receptors: Variations on a Theme
SB Liggett
ASSAY and Drug Development Technologies 2003
Risk Stratification and Management of Sudden Cardiac Death:
N El-Sherif, G Turitto
Journal of Cardiovascular Electrophysiology 2003
??-Adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure
DM Kaye, B Smirk, C Williams, G Jennings, M Esler, D Holst
Pharmacogenetics 2003
Pharmacogenomics of congestive heart failure
RR Baliga, J Narula
Medical Clinics of North America 2003
Multiplex genotyping of the human β2-adrenergic receptor gene using solid-phase capturable dideoxynucleotides and mass spectrometry
S Kim, S Shi, T Bonome, ME Ulz, JR Edwards, H Fodstad, JJ Russo, J Ju
Analytical Biochemistry 2003
Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations
L Klein, CM O’Connor, WA Gattis, M Zampino, L Luca, A Vitarelli, F Fedele, M Gheorghiade
The American Journal of Cardiology 2003
Beta-adrenoceptor polymorphisms
K Leineweber, R Büscher, H Bruck, OE Brodde
Naunyn-Schmiedeberg's Archives of Pharmacology 2003
Gene interventions in the β-adrenergic system for treating heart failure
CJ Parsa, WJ Koch
Seminars in Thoracic and Cardiovascular Surgery 2003
Distribution of arylamine N-acetyltransferase 2 (nat2) genotypes among Omanis
MO Tanira, M Simsek, KA Balushi, KA Lawatia, HA Barawani, RA Bayoumi
SQU Journal for Scientific Research - Medical Sciences 2003
Risk of Mortality and Heart Failure Exacerbations Associated With Inhaled β-Adrenoceptor Agonists Among Patients With Known Left Ventricular Systolic Dysfunctiona
DH Au, EM Udris, VS Fan, JR Curtis, MB McDonell, SD Fihn
Chest 2003
Hierarchy of Polymorphic Variation and Desensitization Permutations Relative to β 1 - and β 2 -Adrenergic Receptor Signaling
DA Rathz, KN Gregory, Y Fang, KM Brown, SB Liggett
The Journal of biological chemistry 2003
Gene and Protein Domain-Specific Patterns of Genetic Variability Within the G-Protein Coupled Receptor Superfamily:
KM Small, DA Tanguay, K Nandabalan, P Zhan, JC Stephens, SB Liggett
American Journal of PharmacoGenomics 2003
Cardiac Markers
AH Wu
2003
Sympathetic nervous system function as measured by I-123 metaiodobenzylguanidine predicts transplant-free survival in heart failure patients with idiopathic dilated cardiomyopathy
MC Gerson, N McGuire, LE Wagoner
Journal of Cardiac Failure 2003
Seven-transmembrane-spanning receptors and heart function
HA Rockman, WJ Koch, RJ Lefkowitz
Nature 2002
Genetic Polymorphisms and Oxidative Stress in Heart Failure
FM Alameddine, AM Zafari
Congestive Heart Failure 2002
Myocardial beta-adrenoceptor densityone month after acute myocardial infarctionpredicts left ventricular volumes at six months
N Spyrou, SD Rosen, F Fath-Ordoubadi, R Jagathesan, R Foale, JS Kooner, PG Camici
Journal of the American College of Cardiology 2002
Genes and their polymorphisms in mono- and multifactorial cardiomyopathies:
P Charron, M Komajda
Pharmacogenomics 2002
Clinical Importance of ??-Adrenoceptor Polymorphisms in Cardiovascular Disease
DM McNamara, GA MacGowan, B London
American Journal of PharmacoGenomics 2002
Determination of a Novel Haplotype of β2-adrenergic Receptor in the Japanese Population by the Combination of the Electronic Microchip Assay Using the NanoChip System with Allele-specific PCR
N YOSHIDA, M SUGIYAMA, A TANOUE, A HIRASAWA, H SAITO, G TSUJIMOTO
Drug Metabolism and Pharmacokinetics 2002
Adrenergic-Receptor Polymorphisms and Heart Failure
RJ Hajjar, CA MacRae
New England Journal of Medicine 2002
Polymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure
LE Wagoner, LL Craft, P Zengel, N McGuire, DA Rathz, GW Dorn, SB Liggett
American Heart Journal 2002
Beta-adrenoceptor polymorphisms: does altered in vitro function predict in vivo effects?
OE Brodde, R Büscher, K Leineweber, H Bruck
International Congress Series 2002
Genetics in heart failure: Practical incorporation of this new biologic dimension
M Donahue, W Kraus, C Granger
American Heart Journal 2002
Polymorphic G-Protein-Coupled Receptors and Associated Diseases
DM Perez
Receptors and Channels 2002
Role of Race in the Pharmacotherapy of Heart Failure
JS Kalus, JM Nappi
The Annals of pharmacotherapy 2002
Polypharmacy in chronic heart failure: practical issues regarding the use of angiotensin-converting enzyme inhibitors, beta-blockers and other drugs
RA Boer, DJ Veldhuisen
European Heart Journal Supplements 2002
Novel and nondetected human signaling protein polymorphisms
RA Lynch, L Wagoner, S Li, L Sparks, J Molkentin, GW Dorn
Physiological genomics 2002
Positive inotropic stimulation:
M Leone, J Albanse, C Martin
Current Opinion in Critical Care 2002
β-2 Adrenergic receptor gene variations and coping styles in twins
A Busjahn, K Freier, HD Faulhaber, GH Li, M Rosenthal, J Jordan, MR Hoehe, B Timmermann, FC Luft
Biological Psychology 2002
Genetic Modifier Loci Affecting Survival and Cardiac Function in Murine Dilated Cardiomyopathy
M Suzuki, KM Carlson, DA Marchuk, HA Rockman
Circulation 2002
New Trends in Allergy V
J Ring, H Behrendt
2002
Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics
Julie A Johnson, Steven G Terra
Pharmaceutical Research 2002
Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function as measured by iodine 123 metaiodobenzylguanidine.
Gerson MC, Craft LL, McGuire N, Suresh DP, Abraham WT, Wagoner LE
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2002
Marked effects of the Thr164Ile polymorphism in the beta2 adrenoceptor gene on native receptor function and body composition
Johan Hoffstedt, Anastasia Iliadou, Nancy L. Pedersen, Martin Schalling, Peter Arner
British Journal of Pharmacology 2001
Are we ready for pharmacogenomics in heart failure?
P Charron, M Komajda
European Journal of Pharmacology 2001
Genetic polymorphisms of adrenergic receptors
EM Garland, I Biaggioni
Clinical Autonomic Research 2001
Cellular and molecular aspects of myocardial dysfunction
SM Schwartz, JY Duffy, JM Pearl, DP Nelson
Critical Care Medicine 2001
Identification and functional characterization of α2-adrenoceptor polymorphisms
KM Small, SB Liggett
Trends in Pharmacological Sciences 2001
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
WZ Zhu, M Zheng, WJ Koch, RJ Lefkowitz, BK Kobilka, RP Xiao
Proceedings of the National Academy of Sciences 2001
Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene
T Ishimitsu, K Hosoya, K Tsukada, J Minami, H Ono, M Ohrui, J Hino, K Kangawa, H Matsuoka
Peptides 2001
Pharmacogenomics: will it change the field of medicine?
SJ Wieczorek, GJ Tsongalis
Clinica Chimica Acta 2001
Racial Differences in the Response to Drugs — Pointers to Genetic Differences
AJ Wood
New England Journal of Medicine 2001
Dual modulation of cell survival and cell death by  2-adrenergic signaling in adult mouse cardiac myocytes
WZ Zhu, M Zheng, WJ Koch, RJ Lefkowitz, BK Kobilka, RP Xiao
Proceedings of the National Academy of Sciences 2001
Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation
D Chasman, RM Adams
Journal of Molecular Biology 2001
 -Adrenergic Signaling in the Heart: Dual Coupling of the  2-Adrenergic Receptor to Gs and Gi Proteins
RP Xiao
Science signaling 2001
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC
L Chen, H Hahn, G Wu, CH Chen, T Liron, D Schechtman, G Cavallaro, L Banci, Y Guo, R Bolli, GW 2nd, D Mochly-Rosen
Proceedings of the National Academy of Sciences 2001
Altered Beta-adrenergic Receptor Gene Regulation and Signaling in Chronic Heart Failure
JD Port, MR Bristow
Journal of Molecular and Cellular Cardiology 2001
Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death
AR Marks
Journal of Molecular and Cellular Cardiology 2001
Which β-blocker for heart failure?
KF Adams
American Heart Journal 2001
Carvedilol—a new dimension in pediatric heart failure therapy
RL Spicer
The Journal of Pediatrics 2001
Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC
L Chen, H Hahn, G Wu, CH Chen, T Liron, D Schechtman, G Cavallaro, L Banci, Y Guo, R Bolli, GW Dorn, D Mochly-Rosen
Proceedings of the National Academy of Sciences 2001
Beta-adrenergic axis and heart disease
S V Naga Prasad, J Nienaber, H A Rockman
Trends in genetics : TIG 2001
Preprescription Genotyping: Not Yet Ready for Prime Time, but Getting There
DM Roden, NJ Brown
Circulation 2001
Sudden Cardiac Death, Genes, and Arrhythmogenesis: Consideration of New Population and Mechanistic Approaches From a National Heart, Lung, and Blood Institute Workshop, Part II*
PM Spooner, C Albert, EJ Benjamin, R Boineau, RC Elston, AL George, X Jouven, LH Kuller, JW MacCluer, E Marbán, JE Muller, PJ Schwartz, DS Siscovick, RP Tracy, W Zareba, DP Zipes
Circulation 2001
Adrenergic Receptor Polymorphisms and Cardiac Function (and Dysfunction): A Failure to Communicate?
RD Feldman
Circulation 2001
The MIBG tarot: is it possible to predict the efficacy of beta-blockers in congestive heart failure?
Baliga RR, Narula J, Dec GW
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2001
FROM THESARCOMERE TO THENUCLEUS: Role of Genetics and Signaling in Structural Heart Disease
RL Nicol, N Frey, EN Olson
Annual Review of Genomics and Human Genetics 2000
Influence of genetic polymorphisms in the ??2-adrenoceptor on desensitization in human lung mast cells
LK Chong, J Chowdry, P Ghahramani, PT Peachell
Pharmacogenetics 2000
The role of β2-adrenergic receptor variation in human hypertension
MS Bray, E Boerwinkle
Current Hypertension Reports 2000
The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor
H Gong, DL Adamson, HK Ranu, WJ Koch, JF Heubach, U Ravens, O Zolk, SE Harding
British Journal of Pharmacology 2000
SNPs: kleine genetische Varianten große medizinische Wirkungen
D Foernzler
Nachrichten aus der Chemie 2000
A SNPshot: pharmacogenetics and the future of drug therapy
DR Pfost, MT Boyce-Jacino, DM Grant
Trends in Biotechnology 2000
Functional consequences of altering myocardial adrenergic receptor signaling
WJ Koch, RJ Lefkowitz, HA Rockman
Annual Review of Physiology 2000
 2-Adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in whites and African Americans
V Herrmann, R Buscher, MM Go, KM Ring, JK Hofer, MT Kailasam, DT O'Connor, RJ Parmer, PA Insel
American Journal of Hypertension 2000
β 2 -Adrenergic Receptor Pharmacogenetics
SB Liggett
American journal of respiratory and critical care medicine 2000
Functional Evidence for a Cyclic-AMP Related Mechanism of Action of the β2-adrenoceptor in Human Ventricular Myocytes
DL Adamson, AR Money-Kyrle, SE Harding
Journal of Molecular and Cellular Cardiology 2000
A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α 2C -Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors
KM Small, SL Forbes, FF Rahman, KM Bridges, SB Liggett
The Journal of biological chemistry 2000
An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human α 2A -Adrenergic Receptor Imparts Enhanced Agonist-promoted G i Coupling
KM Small, SL Forbes, KM Brown, SB Liggett
The Journal of biological chemistry 2000
G i -dependent suppression of β 1 -adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs
HK Ranu, JC Mak, PJ Barnes, SE Harding
American journal of physiology. Heart and circulatory physiology 2000
Cell Logic for Dual Coupling of a Single Class of Receptors to G s and G i Proteins
RP Xiao
Circulation research 2000
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the β 2 -Adrenergic Receptor in the Heart: Prospects for Molecular Ventricular Assistance
AS Shah, RE Lilly, AP Kypson, O Tai, JA Hata, A Pippen, SC Silvestry, RJ Lefkowitz, DD Glower, WJ Koch
Circulation 2000
β-2 Adrenergic Receptor Gene Variations, Blood Pressure, and Heart Size in Normal Twins
A Busjahn, GH Li, HD Faulhaber, M Rosenthal, A Becker, E Jeschke, H Schuster, B Timmermann, MR Hoehe, FC Luft
Hypertension 2000
Polymorphisms of the β 2 -Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure
LE Wagoner, LL Craft, B Singh, DP Suresh, PW Zengel, N McGuire, WT Abraham, TC Chenier, GW Dorn, SB Liggett
Circulation research 2000
Molecular Genetics of Cardiac Electrophysiology
CI Berul, JA Towbin
2000
The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
T Kenakin, JA Angus
2000
Molecular Approaches to Heart Failure Therapy
G Hasenfuss, E Marbán
2000
Alterations in adrenergic receptor signaling in heart failure
S Lamba, W T Abraham
Heart Failure Reviews 2000
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery
JP Maurice, JA Hata, AS Shah, DC White, PH McDonald, PC Dolber, KH Wilson, RJ Lefkowitz, DD Glower, WJ Koch
Journal of Clinical Investigation 1999
QT Interval Is Linked to 2 Long-QT Syndrome Loci in Normal Subjects
A Busjahn, H Knoblauch, HD Faulhaber, T Boeckel, M Rosenthal, R Uhlmann, M Hoehe, H Schuster, FC Luft
Circulation 1999
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression
DW McGraw, SL Forbes, LA Kramer, SB Liggett
Journal of Clinical Investigation 1998
Editorial
S Wolf
Integrative Physiological and Behavioral Science 1992
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin
The American journal of physiology 1978
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin
The American journal of physiology 1978

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