The beta2-adrenergic receptor (beta2AR), an important modulator of cardiac inotropy and chronotropy, has significant genetic heterogeneity in the population. Because dysfunctional betaARs play a role in the pathogenesis of the failing ventricle, we tested the hypothesis that beta2AR polymorphisms alter the outcome of congestive heart failure. 259 patients with NYHA functional class II-IV heart failure due to ischemic or dilated cardiomyopathy were genotyped and prospectively followed, with the endpoint defined as death or cardiac transplantation. The allele frequencies between this group and those of 212 healthy controls also were compared and did not differ between the groups. However, those with the Ile164 polymorphism displayed a striking difference in survival with a relative risk of death or cardiac transplant of 4.81 (P < 0.001) compared with those with the wild-type Thr at this position. Age, race, gender, functional class, etiology, ejection fraction, and medication use did not differ between these individuals and those with the wild-type beta2AR, and thus the beta2AR genotype at position 164 was the only clear distinguishing feature between the two groups. The 1-yr survival for Ile164 patients was 42% compared with 76% for patients harboring wild-type beta2AR. In contrast, polymorphisms at amino acid positions 16 (Arg or Gly) or 27 (Gln or Glu), which also alter receptor phenotype, did not appear to have an influence on the course of heart failure. Taken together with cell-based and transgenic mouse results, this study establishes a paradigm whereby genetic variants of key signaling elements can have pathophysiologic consequences within the context of a disease. Furthermore, patients with the Ile164 polymorphism and heart failure may be candidates for earlier aggressive intervention or cardiac transplantation.
S B Liggett, L E Wagoner, L L Craft, R W Hornung, B D Hoit, T C McIntosh, R A Walsh
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Adrenoceptor Polymorphisms and the Risk of Cardiac Injury and Dysfunction After Subarachnoid Hemorrhage
JG Zaroff, L Pawlikowska, JC Miss, S Yarlagadda, C Ha, A Achrol, PY Kwok, CE McCulloch, MT Lawton, N Ko, W Smith, WL Young |
Stroke; a journal of cerebral circulation | 2006 |
Neurohumoral activation in heart failure: the role of adrenergic receptors
PC Brum, NP Rolim, AV Bacurau, A Medeiros |
Anais da Academia Brasileira de Ciências | 2006 |
The role of adrenergic receptor polymorphisms in heart failure
A Biolo, AS Rosa, NG Mazzotti, S Martins, A Belló-Klein, LE Rohde, N Clausell |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2006 |
Principles of Molecular Medicine
MS Runge, C Patterson |
2006 | |
Cardiac Adrenoceptors: Physiological and Pathophysiological Relevance
OE Brodde, H Bruck, K Leineweber |
Journal of Pharmacological Sciences | 2006 |
Cardiac Arrhythmias 2005
A Raviele |
2006 | |
Pharmacological treatment of chronic heart failure.
Adorisio R, De Luca L, Rossi J, Gheorghiade M |
Heart Failure Reviews | 2006 |
A polymorphism of the endothelial nitric oxide synthase promoter is associated with advanced autonomic imbalance in patients with congestive heart failure
Philip F. Binkley, Enrico Nunziatta, Yiwen Liu-Stratton, Glen Cooke |
American Heart Journal | 2005 |
Novel human alpha1a-adrenergic receptor single nucleotide polymorphisms alter receptor biological function
Beilei Lei, Daniel P. Morris, Michael P. Smith, Laura P. Svetkey, Mark F. Newman, Jerome I. Rotter, Thomas A. Buchanan, Stephen M. Beckstrom-Sternberg, Eric D. Green, Debra A. Schwinn |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2005 |
The G protein-coupled receptors: Pharmacogenetics and Disease
MD Thompson, WM Burnham, DE Cole |
Critical Reviews in Clinical Laboratory Sciences | 2005 |
No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
S Nonen, H Okamoto, M Akino, Y Matsui, Y Fujio, M Yoshiyama, Y Takemoto, J Yoshikawa, J Azuma, A Kitabatake |
British Journal of Clinical Pharmacology | 2005 |
Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
M Zheng, W Zhu, Q Han, RP Xiao |
Pharmacology & Therapeutics | 2005 |
Pharmacogenetics in drug regulation: promise, potential and pitfalls
RR Shah |
Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 2005 |
164Ile allele in the β2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study
AA Sethi, A Tybjærg-Hansen, GB Jensen, BG Nordestgaard |
Pharmacogenetics and Genomics | 2005 |
??2-Adrenoceptor gene polymorphisms
OE Brodde, K Leineweber |
Pharmacogenetics and Genomics | 2005 |
Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure
P Groote, N Helbecque, N Lamblin, X Hermant, EM Fadden, C Foucher-Hossein, P Amouyel, J Dallongeville, C Bauters |
Pharmacogenetics and Genomics | 2005 |
Mucociliary clearance in patients with chronic asthma: Effects of beta2 agonists
E DAVISKAS, SD ANDERSON, J SHAW, S EBERL, JP SEALE, IA YANG, IH YOUNG |
Respirology | 2005 |
Mechanistic basis of adverse drugreactions: the perils of inappropriate dose schedules
RR Shah |
Expert Opinion on Drug Safety | 2005 |
Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure
DS Feldman, CA Carnes, WT Abraham, MR Bristow |
Nature Clinical Practice Cardiovascular Medicine | 2005 |
The cardiac β2-adrenergic signalling a new role for the cPLA2
C Pavoine, N Defer |
Cellular Signalling | 2005 |
Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis
CM Tang, A Hoerning, R Büscher, DT OʼConnor, F Ratjen, H Grasemann, PA Insel |
Pharmacogenetics and Genomics | 2005 |
Pharmacogenetics: implications for obstetric anesthesia
R Landau |
International Journal of Obstetric Anesthesia | 2005 |
Genetic association studies in cardiology
MP Donahue, AS Allen |
American Heart Journal | 2005 |
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure
G Iaccarino, E Barbato, E Cipolletta, VD Amicis, KB Margulies, D Leosco, B Trimarco, WJ Koch |
European Heart Journal | 2005 |
Pharmacogenomics for Neurohormonal Intervention in Heart Failure
DM McNamara |
Heart Failure Clinics | 2005 |
The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure*
P Groote, N Lamblin, N Helbecque, F Mouquet, EM Fadden, X Hermant, P Amouyel, J Dallongeville, C Bauters |
European Journal of Heart Failure | 2005 |
Monitoring of cardiac function on the basis of serum troponin I levels in patients with acute leukemia treated with anthracyclines
G Specchia, C Buquicchio, N Pansini, FD Serio, V Liso, D Pastore, G Greco, L Ciuffreda, A Mestice, A Liso |
Journal of Laboratory and Clinical Medicine | 2005 |
Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance
R Winker, A Barth, E Valic, R Maier, W Osterode, A Pilger, HW Rdiger |
International Archives of Occupational and Environmental Health | 2005 |
Inhaled ??2-Adrenoceptor Agonists: Cardiovascular Safety in Patients with Obstructive Lung Disease
M Cazzola, MG Matera, CF Donner |
Drugs | 2005 |
Handbook of Cardiac Anatomy, Physiology, and Devices
PA Iaizzo |
2005 | |
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications
RP Xiao, W Zhu, M Zheng, K Chakir, R Bond, EG Lakatta, H Cheng |
Trends in Pharmacological Sciences | 2004 |
Genetic polymorphisms and heart failure
GS Bleumink, AF Schut, MC Sturkenboom, JW Deckers, CM van Duijn, BH Stricker |
Genetics in Medicine | 2004 |
The Emerging Pharmacogenomics of the ?-Adrenergic Receptors
MR Taylor, MR Bristow |
Congestive Heart Failure | 2004 |
Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II)
RR Shah |
British Journal of Clinical Pharmacology | 2004 |
Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead
DW Nebert, ES Vesell |
European Journal of Pharmacology | 2004 |
A Polymorphism of the Gene Encoding AMPD1: Clinical Impact and Proposed Mechanisms in Congestive Heart Failure
PF Binkley, A Auseon, G Cooke |
Congestive Heart Failure | 2004 |
??2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo
V Dishy, R Landau, GG Sofowora, HG Xie, RM Smiley, RB Kim, DW Byrne, AJ Wood, CM Stein |
Pharmacogenetics | 2004 |
Viral-Based Myocardial Gene Therapy Approaches to Alter Cardiac Function
ML Williams, WJ Koch |
Annual Review of Physiology | 2004 |
β2-adrenoceptor polymorphisms: Relation between in vitro and in vivo phenotypes
K Leineweber, OE Brodde |
Life Sciences | 2004 |
Pharmacogenomics of adrenoceptors
C Flordellis, H Paris, A Karabinis, A Lymperopoulos |
Pharmacogenomics | 2004 |
Interaction between cardiac sympathetic drive and heart rate in heart failure
DM Kaye, B Smirk, S Finch, C Williams, MD Esler |
Journal of the American College of Cardiology | 2004 |
β-Adrenoceptor polymorphisms and heart failure
MJ Lohse |
Trends in Molecular Medicine | 2004 |
?-Adrenoceptor Blockers as Agonists: Coupling of ?2-Adrenoceptors to Multiple G-Proteins in the Failing Human Heart
SE Harding, H Gong |
Congestive Heart Failure | 2004 |
Frequency of compound genotypes associated with β-blocker efficacy in congestive heart failure
DE Lanfear, S Marsh, S Cresci, JA Spertus, HL McLeod |
Pharmacogenomics | 2004 |
Genetic predisposition to heart failure
M Pasotti, A Repetto, L Tavazzi, E Arbustini |
Medical Clinics of North America | 2004 |
Regulation of cardiac contractility by Rab4-modulated β2-adrenergic receptor recycling
A Odley, HS Hahn, RA Lynch, Y Marreez, H Osinska, J Robbins, GW 2nd |
Proceedings of the National Academy of Sciences | 2004 |
Polymorphisms of β-adrenergic receptors in heart failure
SB Liggett |
The American Journal of Medicine | 2004 |
Association between chronic heart failure and inhaled β-2-adrenoceptor agonists
DH Au, EM Udris, JR Curtis, MB McDonell, SD Fihn |
American Heart Journal | 2004 |
Beta‐adrenergic receptor polymorphism in human cardiovascular disease
K Leineweber |
Annals of Medicine | 2004 |
Haplotype Analysis of the β2 Adrenergic Receptor Gene and Risk of Myocardial Infarction in Humans
RY Zee, NR Cook, R Reynolds, S Cheng, PM Ridker |
Genetics | 2004 |
The Glu27 allele of the ??2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension:
G Iaccarino, F Lanni, E Cipolletta, V Trimarco, R Izzo, GL Iovino, ND Luca, B Trimarco |
Journal of Hypertension | 2004 |
Pharmacogenetic Aspects of Drug-Induced Torsade de Pointes: Potential Tool for Improving Clinical Drug Development and Prescribing
RR Shah |
Drug Safety | 2004 |
Cardiovascular Pharmacogenetics
MR Wilkins |
2004 | |
beta2-Adrenergic signaling in human heart: shift from the cyclic AMP to the arachidonic acid pathway
C Pavoine, N Behforouz, C Gauthier, SL Gouvello, F Roudot-Thoraval, CR Martin, A Pawlak, C Feral, N Defer, R Houel, S Magne, A Amadou, D Loisance, P Duvaldestin, F Pecker |
Molecular pharmacology | 2003 |
Gender, Ethnicity and Genetics in Cardiovascular Disease
BM Schaefer, V Caracciolo, WH Frishman, P Charney |
Heart Disease | 2003 |
Targeting signaling pathways in heart failure by gene transfer
BD MacNeill, M Hayase, RJ Hajjar |
Current Atherosclerosis Reports | 2003 |
The emerging role of pharmacogenomics in the treatment of patients with heart failure
AM Feldman |
The Annals of Thoracic Surgery | 2003 |
PHARMACOLOGY ANDPHYSIOLOGY OFHUMANADRENERGICRECEPTORPOLYMORPHISMS
KM Small, DW McGraw, SB Liggett |
Annual Review of Pharmacology and Toxicology | 2003 |
Emerging therapeutic targets in chronic heart failure: Part II
V Roenicke, S Leclair, A Hoffmann, M Becker, T Szado, T Kirsch, O Stoss, BT Navé, T Henkel |
Expert Opinion on Therapeutic Targets | 2003 |
Polymorphisms of Adrenergic Receptors: Variations on a Theme
SB Liggett |
ASSAY and Drug Development Technologies | 2003 |
Risk Stratification and Management of Sudden Cardiac Death:
N El-Sherif, G Turitto |
Journal of Cardiovascular Electrophysiology | 2003 |
??-Adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure
DM Kaye, B Smirk, C Williams, G Jennings, M Esler, D Holst |
Pharmacogenetics | 2003 |
Pharmacogenomics of congestive heart failure
RR Baliga, J Narula |
Medical Clinics of North America | 2003 |
Multiplex genotyping of the human β2-adrenergic receptor gene using solid-phase capturable dideoxynucleotides and mass spectrometry
S Kim, S Shi, T Bonome, ME Ulz, JR Edwards, H Fodstad, JJ Russo, J Ju |
Analytical Biochemistry | 2003 |
Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations
L Klein, CM O’Connor, WA Gattis, M Zampino, L Luca, A Vitarelli, F Fedele, M Gheorghiade |
The American Journal of Cardiology | 2003 |
Beta-adrenoceptor polymorphisms
K Leineweber, R Büscher, H Bruck, OE Brodde |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2003 |
Gene interventions in the β-adrenergic system for treating heart failure
CJ Parsa, WJ Koch |
Seminars in Thoracic and Cardiovascular Surgery | 2003 |
Distribution of arylamine N-acetyltransferase 2 (nat2) genotypes among Omanis
MO Tanira, M Simsek, KA Balushi, KA Lawatia, HA Barawani, RA Bayoumi |
SQU Journal for Scientific Research - Medical Sciences | 2003 |
Risk of Mortality and Heart Failure Exacerbations Associated With Inhaled β-Adrenoceptor Agonists Among Patients With Known Left Ventricular Systolic Dysfunctiona
DH Au, EM Udris, VS Fan, JR Curtis, MB McDonell, SD Fihn |
Chest | 2003 |
Hierarchy of Polymorphic Variation and Desensitization Permutations Relative to β 1 - and β 2 -Adrenergic Receptor Signaling
DA Rathz, KN Gregory, Y Fang, KM Brown, SB Liggett |
The Journal of biological chemistry | 2003 |
Gene and Protein Domain-Specific Patterns of Genetic Variability Within the G-Protein Coupled Receptor Superfamily:
KM Small, DA Tanguay, K Nandabalan, P Zhan, JC Stephens, SB Liggett |
American Journal of PharmacoGenomics | 2003 |
Cardiac Markers
AH Wu |
2003 | |
Sympathetic nervous system function as measured by I-123 metaiodobenzylguanidine predicts transplant-free survival in heart failure patients with idiopathic dilated cardiomyopathy
MC Gerson, N McGuire, LE Wagoner |
Journal of Cardiac Failure | 2003 |
Seven-transmembrane-spanning receptors and heart function
HA Rockman, WJ Koch, RJ Lefkowitz |
Nature | 2002 |
Genetic Polymorphisms and Oxidative Stress in Heart Failure
FM Alameddine, AM Zafari |
Congestive Heart Failure | 2002 |
Myocardial beta-adrenoceptor densityone month after acute myocardial infarctionpredicts left ventricular volumes at six months
N Spyrou, SD Rosen, F Fath-Ordoubadi, R Jagathesan, R Foale, JS Kooner, PG Camici |
Journal of the American College of Cardiology | 2002 |
Genes and their polymorphisms in mono- and multifactorial cardiomyopathies:
P Charron, M Komajda |
Pharmacogenomics | 2002 |
Clinical Importance of ??-Adrenoceptor Polymorphisms in Cardiovascular Disease
DM McNamara, GA MacGowan, B London |
American Journal of PharmacoGenomics | 2002 |
Determination of a Novel Haplotype of β2-adrenergic Receptor in the Japanese Population by the Combination of the Electronic Microchip Assay Using the NanoChip System with Allele-specific PCR
N YOSHIDA, M SUGIYAMA, A TANOUE, A HIRASAWA, H SAITO, G TSUJIMOTO |
Drug Metabolism and Pharmacokinetics | 2002 |
Adrenergic-Receptor Polymorphisms and Heart Failure
RJ Hajjar, CA MacRae |
New England Journal of Medicine | 2002 |
Polymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure
LE Wagoner, LL Craft, P Zengel, N McGuire, DA Rathz, GW Dorn, SB Liggett |
American Heart Journal | 2002 |
Beta-adrenoceptor polymorphisms: does altered in vitro function predict in vivo effects?
OE Brodde, R Büscher, K Leineweber, H Bruck |
International Congress Series | 2002 |
Genetics in heart failure: Practical incorporation of this new biologic dimension
M Donahue, W Kraus, C Granger |
American Heart Journal | 2002 |
Polymorphic G-Protein-Coupled Receptors and Associated Diseases
DM Perez |
Receptors and Channels | 2002 |
Role of Race in the Pharmacotherapy of Heart Failure
JS Kalus, JM Nappi |
The Annals of pharmacotherapy | 2002 |
Polypharmacy in chronic heart failure: practical issues regarding the use of angiotensin-converting enzyme inhibitors, beta-blockers and other drugs
RA Boer, DJ Veldhuisen |
European Heart Journal Supplements | 2002 |
Novel and nondetected human signaling protein polymorphisms
RA Lynch, L Wagoner, S Li, L Sparks, J Molkentin, GW Dorn |
Physiological genomics | 2002 |
Positive inotropic stimulation:
M Leone, J Albanse, C Martin |
Current Opinion in Critical Care | 2002 |
β-2 Adrenergic receptor gene variations and coping styles in twins
A Busjahn, K Freier, HD Faulhaber, GH Li, M Rosenthal, J Jordan, MR Hoehe, B Timmermann, FC Luft |
Biological Psychology | 2002 |
Genetic Modifier Loci Affecting Survival and Cardiac Function in Murine Dilated Cardiomyopathy
M Suzuki, KM Carlson, DA Marchuk, HA Rockman |
Circulation | 2002 |
New Trends in Allergy V
J Ring, H Behrendt |
2002 | |
Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics
Julie A Johnson, Steven G Terra |
Pharmaceutical Research | 2002 |
Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function as measured by iodine 123 metaiodobenzylguanidine.
Gerson MC, Craft LL, McGuire N, Suresh DP, Abraham WT, Wagoner LE |
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology | 2002 |
Marked effects of the Thr164Ile polymorphism in the beta2 adrenoceptor gene on native receptor function and body composition
Johan Hoffstedt, Anastasia Iliadou, Nancy L. Pedersen, Martin Schalling, Peter Arner |
British Journal of Pharmacology | 2001 |
Are we ready for pharmacogenomics in heart failure?
P Charron, M Komajda |
European Journal of Pharmacology | 2001 |
Genetic polymorphisms of adrenergic receptors
EM Garland, I Biaggioni |
Clinical Autonomic Research | 2001 |
Cellular and molecular aspects of myocardial dysfunction
SM Schwartz, JY Duffy, JM Pearl, DP Nelson |
Critical Care Medicine | 2001 |
Identification and functional characterization of α2-adrenoceptor polymorphisms
KM Small, SB Liggett |
Trends in Pharmacological Sciences | 2001 |
Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
WZ Zhu, M Zheng, WJ Koch, RJ Lefkowitz, BK Kobilka, RP Xiao |
Proceedings of the National Academy of Sciences | 2001 |
Chromosomal sublocalization and microsatellite DNA polymorphism of human adrenomedullin gene
T Ishimitsu, K Hosoya, K Tsukada, J Minami, H Ono, M Ohrui, J Hino, K Kangawa, H Matsuoka |
Peptides | 2001 |
Pharmacogenomics: will it change the field of medicine?
SJ Wieczorek, GJ Tsongalis |
Clinica Chimica Acta | 2001 |
Racial Differences in the Response to Drugs — Pointers to Genetic Differences
AJ Wood |
New England Journal of Medicine | 2001 |
Dual modulation of cell survival and cell death by 2-adrenergic signaling in adult mouse cardiac myocytes
WZ Zhu, M Zheng, WJ Koch, RJ Lefkowitz, BK Kobilka, RP Xiao |
Proceedings of the National Academy of Sciences | 2001 |
Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation
D Chasman, RM Adams |
Journal of Molecular Biology | 2001 |
-Adrenergic Signaling in the Heart: Dual Coupling of the 2-Adrenergic Receptor to Gs and Gi Proteins
RP Xiao |
Science signaling | 2001 |
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC
L Chen, H Hahn, G Wu, CH Chen, T Liron, D Schechtman, G Cavallaro, L Banci, Y Guo, R Bolli, GW 2nd, D Mochly-Rosen |
Proceedings of the National Academy of Sciences | 2001 |
Altered Beta-adrenergic Receptor Gene Regulation and Signaling in Chronic Heart Failure
JD Port, MR Bristow |
Journal of Molecular and Cellular Cardiology | 2001 |
Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death
AR Marks |
Journal of Molecular and Cellular Cardiology | 2001 |
Which β-blocker for heart failure?
KF Adams |
American Heart Journal | 2001 |
Carvedilol—a new dimension in pediatric heart failure therapy
RL Spicer |
The Journal of Pediatrics | 2001 |
Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC
L Chen, H Hahn, G Wu, CH Chen, T Liron, D Schechtman, G Cavallaro, L Banci, Y Guo, R Bolli, GW Dorn, D Mochly-Rosen |
Proceedings of the National Academy of Sciences | 2001 |
Beta-adrenergic axis and heart disease
S V Naga Prasad, J Nienaber, H A Rockman |
Trends in genetics : TIG | 2001 |
Preprescription Genotyping: Not Yet Ready for Prime Time, but Getting There
DM Roden, NJ Brown |
Circulation | 2001 |
Sudden Cardiac Death, Genes, and Arrhythmogenesis: Consideration of New Population and Mechanistic Approaches From a National Heart, Lung, and Blood Institute Workshop, Part II*
PM Spooner, C Albert, EJ Benjamin, R Boineau, RC Elston, AL George, X Jouven, LH Kuller, JW MacCluer, E Marbán, JE Muller, PJ Schwartz, DS Siscovick, RP Tracy, W Zareba, DP Zipes |
Circulation | 2001 |
Adrenergic Receptor Polymorphisms and Cardiac Function (and Dysfunction): A Failure to Communicate?
RD Feldman |
Circulation | 2001 |
The MIBG tarot: is it possible to predict the efficacy of beta-blockers in congestive heart failure?
Baliga RR, Narula J, Dec GW |
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology | 2001 |
FROM THESARCOMERE TO THENUCLEUS: Role of Genetics and Signaling in Structural Heart Disease
RL Nicol, N Frey, EN Olson |
Annual Review of Genomics and Human Genetics | 2000 |
Influence of genetic polymorphisms in the ??2-adrenoceptor on desensitization in human lung mast cells
LK Chong, J Chowdry, P Ghahramani, PT Peachell |
Pharmacogenetics | 2000 |
The role of β2-adrenergic receptor variation in human hypertension
MS Bray, E Boerwinkle |
Current Hypertension Reports | 2000 |
The effect of Gi-protein inactivation on basal, and beta(1)- and beta(2)AR-stimulated contraction of myocytes from transgenic mice overexpressing the beta(2)-adrenoceptor
H Gong, DL Adamson, HK Ranu, WJ Koch, JF Heubach, U Ravens, O Zolk, SE Harding |
British Journal of Pharmacology | 2000 |
SNPs: kleine genetische Varianten große medizinische Wirkungen
D Foernzler |
Nachrichten aus der Chemie | 2000 |
A SNPshot: pharmacogenetics and the future of drug therapy
DR Pfost, MT Boyce-Jacino, DM Grant |
Trends in Biotechnology | 2000 |
Functional consequences of altering myocardial adrenergic receptor signaling
WJ Koch, RJ Lefkowitz, HA Rockman |
Annual Review of Physiology | 2000 |
2-Adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in whites and African Americans
V Herrmann, R Buscher, MM Go, KM Ring, JK Hofer, MT Kailasam, DT O'Connor, RJ Parmer, PA Insel |
American Journal of Hypertension | 2000 |
β 2 -Adrenergic Receptor Pharmacogenetics
SB Liggett |
American journal of respiratory and critical care medicine | 2000 |
Functional Evidence for a Cyclic-AMP Related Mechanism of Action of the β2-adrenoceptor in Human Ventricular Myocytes
DL Adamson, AR Money-Kyrle, SE Harding |
Journal of Molecular and Cellular Cardiology | 2000 |
A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α 2C -Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors
KM Small, SL Forbes, FF Rahman, KM Bridges, SB Liggett |
The Journal of biological chemistry | 2000 |
An Asn to Lys Polymorphism in the Third Intracellular Loop of the Human α 2A -Adrenergic Receptor Imparts Enhanced Agonist-promoted G i Coupling
KM Small, SL Forbes, KM Brown, SB Liggett |
The Journal of biological chemistry | 2000 |
G i -dependent suppression of β 1 -adrenoceptor effects in ventricular myocytes from NE-treated guinea pigs
HK Ranu, JC Mak, PJ Barnes, SE Harding |
American journal of physiology. Heart and circulatory physiology | 2000 |
Cell Logic for Dual Coupling of a Single Class of Receptors to G s and G i Proteins
RP Xiao |
Circulation research | 2000 |
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the β 2 -Adrenergic Receptor in the Heart: Prospects for Molecular Ventricular Assistance
AS Shah, RE Lilly, AP Kypson, O Tai, JA Hata, A Pippen, SC Silvestry, RJ Lefkowitz, DD Glower, WJ Koch |
Circulation | 2000 |
β-2 Adrenergic Receptor Gene Variations, Blood Pressure, and Heart Size in Normal Twins
A Busjahn, GH Li, HD Faulhaber, M Rosenthal, A Becker, E Jeschke, H Schuster, B Timmermann, MR Hoehe, FC Luft |
Hypertension | 2000 |
Polymorphisms of the β 2 -Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure
LE Wagoner, LL Craft, B Singh, DP Suresh, PW Zengel, N McGuire, WT Abraham, TC Chenier, GW Dorn, SB Liggett |
Circulation research | 2000 |
Molecular Genetics of Cardiac Electrophysiology
CI Berul, JA Towbin |
2000 | |
The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
T Kenakin, JA Angus |
2000 | |
Molecular Approaches to Heart Failure Therapy
G Hasenfuss, E Marbán |
2000 | |
Alterations in adrenergic receptor signaling in heart failure
S Lamba, W T Abraham |
Heart Failure Reviews | 2000 |
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery
JP Maurice, JA Hata, AS Shah, DC White, PH McDonald, PC Dolber, KH Wilson, RJ Lefkowitz, DD Glower, WJ Koch |
Journal of Clinical Investigation | 1999 |
QT Interval Is Linked to 2 Long-QT Syndrome Loci in Normal Subjects
A Busjahn, H Knoblauch, HD Faulhaber, T Boeckel, M Rosenthal, R Uhlmann, M Hoehe, H Schuster, FC Luft |
Circulation | 1999 |
Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression
DW McGraw, SL Forbes, LA Kramer, SB Liggett |
Journal of Clinical Investigation | 1998 |
Editorial
S Wolf |
Integrative Physiological and Behavioral Science | 1992 |
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin |
The American journal of physiology | 1978 |
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin |
The American journal of physiology | 1978 |