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Steven E. Bosinger, … , Ashley T. Haase, David J. Kelvin
Published November 23, 2009
Citation Information: J Clin Invest. 2009;119(12):3556-3572. https://doi.org/10.1172/JCI40115.
Citation Information: J Clin Invest. 2009;119(12):3556-3572. https://doi.org/10.1172/JCI40115.
Abstract
Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques (RMs) is associated with chronic immune activation. To elucidate the mechanisms underlying this intriguing phenotype, we used high-density oligonucleotide microarrays to longitudinally assess host gene expression in SIV-infected SMs and RMs. We found that acute SIV infection of SMs was consistently associated with a robust innate immune response, including widespread upregulation of IFN-stimulated genes (ISGs) in blood and lymph nodes. While SMs exhibited a rapid resolution of ISG expression and immune activation, both responses were observed chronically in RMs. Systems biology analysis indicated that expression of the lymphocyte inhibitory receptor LAG3, a marker of T cell exhaustion, correlated with immune activation in SIV-infected RMs but not SMs. Our findings suggest that active immune regulatory mechanisms, rather than intrinsically attenuated innate immune responses, underlie the low levels of immune activation characteristic of SMs chronically infected with SIV.
Authors
Steven E. Bosinger, Qingsheng Li, Shari N. Gordon, Nichole R. Klatt, Lijie Duan, Luoling Xu, Nicholas Francella, Abubaker Sidahmed, Anthony J. Smith, Elizabeth M. Cramer, Ming Zeng, David Masopust, John V. Carlis, Longsi Ran, Thomas H. Vanderford, Mirko Paiardini, R. Benjamin Isett, Don A. Baldwin, James G. Else, Silvija I. Staprans, Guido Silvestri, Ashley T. Haase, David J. Kelvin
Total citations by year
Citation information
Citations to this article (264)
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Clinical Infectious Diseases | 2017 |
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Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis
AO Moguche, M Musvosvi, A Penn-Nicholson, CR Plumlee, H Mearns, H Geldenhuys, E Smit, D Abrahams, V Rozot, O Dintwe, ST Hoff, I Kromann, M Ruhwald, P Bang, RP Larson, S Shafiani, S Ma, DR Sherman, A Sette, CS Arlehamn, DM McKinney, H Maecker, WA Hanekom, M Hatherill, P Andersen, TJ Scriba, KB Urdahl |
Cell Host & Microbe | 2017 |
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Early type I Interferon response induces upregulation of human β-defensin 1 during acute HIV-1 infection
B Corleis, AC Lisanti, C Körner, AE Schiff, ES Rosenberg, TM Allen, M Altfeld, DS Kwon, A Cimarelli |
PloS one | 2017 |
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Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence
HY Zheng, MX Zhang, M Chen, J Jiang, JH Song, XD Lian, RR Tian, XL Zhang, LT Zhang, W Pang, GH Zhang, YT Zheng |
Scientific Reports | 2017 |
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Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells
S Reiss, AE Baxter, KM Cirelli, JM Dan, A Morou, A Daigneault, N Brassard, G Silvestri, JP Routy, C Havenar-Daughton, S Crotty, DE Kaufmann, LC Ndhlovu |
PloS one | 2017 |
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Type I Interferon in Chronic Virus Infection and Cancer
LM Snell, TL McGaha, DG Brooks |
Trends in Immunology | 2017 |
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Blockade of type I interferon signaling during cART rescues T-cell functions and reduces HIV-1 reservoirs
Liang Cheng, Jianping Ma, Jingyun Li, Dan Li, Guangming Li, Feng Li, Qing Zhang, Haisheng Yu, Fumihiko Yasui, Chaobaihui Ye, li-chung Tsao, zhiyuan Hu, Lishan Su, Liguo Zhang |
Journal of Clinical Investigation | 2016 |
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Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis
F Calascibetta, L Micci, D Carnathan, B Lawson, TH Vanderford, SE Bosinger, K Easley, A Chahroudi, J Mackel, BF Keele, S Long, J Lifson, M Paiardini, G Silvestri, F Kirchhoff |
Journal of virology | 2016 |
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Type I interferons in viral control and immune regulation
JR Teijaro |
Current Opinion in Virology | 2016 |
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Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses
J R Teijaro |
Advances in immunology | 2016 |
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Early treatment with reverse transcriptase inhibitors significantly suppresses peak plasma IFNα in vivo during acute simian immunodeficiency virus infection
J George, L Renn, D Verthelyi, M Roederer, RL Rabin, JJ Mattapallil |
Cellular Immunology | 2016 |
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Stimulation of PBMC and Monocyte-Derived Macrophages via Toll-Like Receptor Activates Innate Immune Pathways in HIV-Infected Patients on Virally Suppressive Combination Antiretroviral Therapy
E Merlini, C Tincati, M Biasin, I Saulle, FA Cazzaniga, AA Monforte, AJ Cappione, J Snyder-Cappione, M Clerici, GC Marchetti |
Frontiers in immunology | 2016 |
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Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque
ZW Yang, YH Jiang, C Ma, G Silvestri, SE Bosinger, BL Li, A Jong, YH Zhou, SH Huang, C Apetrei |
PloS one | 2016 |
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The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression
K Raehtz, I Pandrea, C Apetrei |
Infection, Genetics and Evolution | 2016 |
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Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset
MJ Ploquin, Y Madec, A Casrouge, N Huot, C Passaes, C Lécuroux, A Essat, F Boufassa, B Jacquelin, SP Jochems, G Petitjean, M Angin, K Gärtner, T Garcia-Tellez, N Noël, T Booiman, BD Boeser-Nunnink, P Roques, A Saez-Cirion, B Vaslin, N Dereudre-Bosquet, F Barré-Sinoussi, M Ghislain, C Rouzioux, O Lambotte, ML Albert, C Goujard, N Kootstra, L Meyer, MC Müller-Trutwin, DC Douek |
PLoS pathogens | 2016 |
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Role of HLA Adaptation in HIV Evolution
HN Kløverpris, A Leslie, P Goulder |
Frontiers in immunology | 2016 |
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Nonpathogenic SIV and Pathogenic HIV Infections Associate with Disparate Innate Cytokine Signatures in Response to Mycobacterium bovis BCG
MA Gasper, SP Biswas, BS Fisher, SC Ehnert, DR Sherman, DL Sodora, AA Ansari |
PloS one | 2016 |
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Interferons and HIV Infection: The Good, the Bad, and the Ugly
NS Utay, DC Douek |
Pathogens and Immunity | 2016 |
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Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection
A Murira, A Lamarre |
Frontiers in immunology | 2016 |
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Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo
KJ Lavender, K Gibbert, KE Peterson, EV Dis, S Francois, T Woods, RJ Messer, A Gawanbacht, JA Müller, J Münch, K Phillips, B Race, MS Harper, K Guo, EJ Lee, M Trilling, H Hengel, J Piehler, J Verheyen, CC Wilson, ML Santiago, KJ Hasenkrug, U Dittmer, G Silvestri |
Journal of virology | 2016 |
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Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated
SD Kijewski, H Akiyama, A Feizpour, CM Miller, NG Ramirez, BM Reinhard, S Gummuluru |
Virology | 2016 |
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The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1
JM Jacobson, SE Bosinger, M Kang, P Belaunzaran-Zamudio, RM Matining, CC Wilson, C Flexner, B Clagett, J Plants, S Read, L Purdue, L Myers, L Boone, P Tebas, P Kumar, D Clifford, D Douek, G Silvestri, AL Landay, MM Lederman |
AIDS Research and Human Retroviruses | 2016 |
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Oxidative Stress during HIV Infection: Mechanisms and Consequences
AV Ivanov, VT Valuev-Elliston, ON Ivanova, SN Kochetkov, ES Starodubova, B Bartosch, MG Isaguliants |
Oxidative medicine and cellular longevity | 2016 |
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Innate and Adaptive Immune Regulation During Chronic Viral Infections
EI Zuniga, M Macal, GM Lewis, JA Harker |
Annual Review of Virology | 2015 |
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Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients
G d’Ettorre, G Ceccarelli, M Andreotti, C Selvaggi, N Giustini, S Serafino, I Schietroma, G Nunnari, G Antonelli, V Vullo, C Scagnolari |
Mediators of Inflammation | 2015 |
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HIV-1 and interferons: who's interfering with whom?
T Doyle, C Goujon, MH Malim |
Nature Reviews Microbiology | 2015 |
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Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections
S Davidson, MK Maini, A Wack |
Journal of Interferon & Cytokine Research | 2015 |
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Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options
V Velu, RD Shetty, M Larsson, EM Shankar |
Retrovirology | 2015 |
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Longitudinal Changes in Plasma Caspase-1 and Caspase-3 during the First 2 Years of HIV-1 Infection in CD4Low and CD4High Patient Groups
J Song, Y Jiao, T Zhang, Y Zhang, X Huang, H Li, H Wu, ML Santiago |
PloS one | 2015 |
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Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections
EJ Greenwood, F Schmidt, I Kondova, H Niphuis, VL Hodara, L Clissold, K McLay, B Guerra, S Redrobe, LD Giavedoni, RE Lanford, KK Murthy, F Rouet, JL Heeney, G Silvestri |
PLoS pathogens | 2015 |
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Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues
T He, E Brocca-Cofano, DG Gillespie, C Xu, JL Stock, D Ma, BB Policicchio, KD Raehtz, CR Rinaldo, C Apetrei, EK Jackson, BJ Macatangay, I Pandrea, G Silvestri |
Journal of virology | 2015 |
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Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors
NE Riddick, F Wu, K Matsuda, S Whitted, I Ourmanov, S Goldstein, RM Goeken, RJ Plishka, A Buckler-White, JM Brenchley, VM Hirsch, G Silvestri |
Journal of virology | 2015 |
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Reducing IRF-1 to Levels Observed in HESN Subjects Limits HIV Replication, But Not the Extent of Host Immune Activation
RC Su, A Plesniarski, Z Ao, J Kimani, A Sivro, W Jaoko, FA Plummer, X Yao, TB Ball |
Molecular Therapy — Nucleic Acids | 2015 |
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Gene therapy with plasmids encoding IFN-β or IFN-α14 confers long-term resistance to HIV-1 in humanized mice
S Abraham, JG Choi, NM Ortega, J Zhang, P Shankar, NM Swamy |
Oncotarget | 2015 |
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Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment
JA Juno, AT Stalker, JL Waruk, J Oyugi, M Kimani, FA Plummer, J Kimani, KR Fowke |
Retrovirology | 2015 |
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Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy
SE Bosinger, NS Utay |
Current HIV/AIDS Reports | 2015 |
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Involvement of Neutrophil Hyporesponse and the Role of Toll-Like Receptors in Human Immunodeficiency Virus 1 Protection
JC Hernandez, DM Giraldo, S Paul, S Urcuqui-Inchima, R Ahmad |
PloS one | 2015 |
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Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4 + T cells, and disease progression
DT Claiborne, JL Prince, E Scully, G Macharia, L Micci, B Lawson, J Kopycinski, MJ Deymier, TH Vanderford, K Nganou-Makamdop, Z Ende, K Brooks, J Tang, T Yu, S Lakhi, W Kilembe, G Silvestri, D Douek, PA Goepfert, MA Price, SA Allen, M Paiardini, M Altfeld, J Gilmour, E Hunter |
Proceedings of the National Academy of Sciences | 2015 |
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Guarding the frontiers: the biology of type III interferons
A Wack, E Terczyńska-Dyla, R Hartmann |
Nature Immunology | 2015 |
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Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach
SA Vishwanathan, A Burgener, SE Bosinger, GK Tharp, PC Guenthner, NB Patel, K Birse, DL Hanson, GR Westmacott, TR Henning, J Radzio, JG Garcia-Lerma, TB Ball, JM McNicholl, EN Kersh, F Kirchhoff |
Journal of virology | 2015 |
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Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection
TW Glavan, CA Gaulke, CS Rocha, S Sankaran-Walters, LA Hirao, M Raffatellu, G Jiang, AJ Bäumler, LR Goulart, S Dandekar |
Mucosal Immunology | 2015 |
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Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif
MW Breed, SE Elser, W Torben, AP Jordan, PP Aye, C Midkiff, F Schiro, C Sugimoto, X Alvarez-Hernandez, RV Blair, A Somasunderam, NS Utay, MJ Kuroda, B Pahar, RW Wiseman, DH O'Connor, CC LaBranche, DC Montefiori, M Marsh, Y Li, M Piatak, JD Lifson, BF Keele, PN Fultz, AA Lackner, JA Hoxie, F Kirchhoff |
Journal of virology | 2015 |
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Plasmacytoid dendritic cell dynamics tune interferon-alfa production in SIV-infected cynomolgus macaques
T Bruel, S Dupuy, T Démoulins, C Rogez-Kreuz, J Dutrieux, A Corneau, A Cosma, R Cheynier, N Dereuddre-Bosquet, RL Grand, B Vaslin |
PLoS pathogens | 2014 |
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Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals
NR Klatt, SE Bosinger, M Peck, LE Richert-Spuhler, A Heigele, JP Gile, N Patel, J Taaffe, B Julg, D Camerini, C Torti, JN Martin, SG Deeks, E Sinclair, FM Hecht, MM Lederman, M Paiardini, F Kirchhoff, JM Brenchley, PW Hunt, G Silvestri |
PLoS pathogens | 2014 |
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Increased Stability and Limited Proliferation of CD4+ Central Memory T Cells Differentiate Nonprogressive Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabeys from Progressive SIV Infection of Rhesus Macaques
CS McGary, B Cervasi, A Chahroudi, L Micci, J Taaffe, T Meeker, G Silvestri, MP Davenport, M Paiardini |
Journal of virology | 2014 |
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types
E Tomasello, E Pollet, TP Manh, G Uzé, M Dalod |
Frontiers in immunology | 2014 |
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Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis
CL Saout, RB Hasley, H Imamichi, L Tcheung, Z Hu, MA Luckey, JH Park, SK Durum, M Smith, AW Rupert, MC Sneller, HC Lane, M Catalfamo |
PLoS pathogens | 2014 |
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Dendritic cells in progression and pathology of HIV infection
O Manches, D Frleta, N Bhardwaj |
Trends in Immunology | 2014 |
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Modulation of HIV-1-Induced Activation of Plasmacytoid Dendritic Cells by 6-Desfluoroquinolones
CM Royle, MH Tsai, O Tabarrini, S Massari, DR Graham, VN Aquino, A Boasso |
AIDS Research and Human Retroviruses | 2014 |
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Transient Increase of Interferon-Stimulated Genes and No Clinical Benefit by Chloroquine Treatment During Acute Simian Immunodeficiency Virus Infection of Macaques
M Vaccari, C Fenizia, ZM Ma, A Hryniewicz, A Boasso, MN Doster, CJ Miller, N Lindegardh, J Tarning, AL Landay, GM Shearer, G Franchini |
AIDS Research and Human Retroviruses | 2014 |
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Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice
G Li, M Cheng, JI Nunoya, L Cheng, H Guo, H Yu, YJ Liu, L Su, L Zhang |
PLoS pathogens | 2014 |
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Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection
B Jacquelin, G Petitjean, D Kunkel, AS Liovat, SP Jochems, KA Rogers, MJ Ploquin, Y Madec, F Barré-Sinoussi, N Dereuddre-Bosquet, P Lebon, RL Grand, F Villinger, M Müller-Trutwin |
PLoS pathogens | 2014 |
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Modulation of Type I Interferon-Associated Viral Sensing during Acute Simian Immunodeficiency Virus Infection in African Green Monkeys
SP Jochems, G Petitjean, D Kunkel, AS Liovat, MJ Ploquin, F Barré-Sinoussi, P Lebon, B Jacquelin, MC Müller-Trutwin, G Silvestri |
Journal of virology | 2014 |
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HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells
S Kukkonen, MD Martinez-Viedma, N Kim, M Manrique, A Aldovini |
Retrovirology | 2014 |
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Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline
JL Drewes, GL Szeto, EL Engle, Z Liao, GM Shearer, MC Zink, DR Graham |
PloS one | 2014 |
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Disentangling Human Tolerance and Resistance Against HIV
RR Regoes, PJ McLaren, M Battegay, E Bernasconi, A Calmy, HF Günthard, M Hoffmann, A Rauch, A Telenti, J Fellay, DS Schneider |
PLoS Biology | 2014 |
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Can early therapy reduce inflammation?:
NG Sandler, I Sereti |
Current Opinion in HIV and AIDS | 2014 |
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Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection
A Crawford, JM Angelosanto, C Kao, TA Doering, PM Odorizzi, BE Barnett, EJ Wherry |
Immunity | 2014 |
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Immunity to HIV in Early Life
M Muenchhoff, AJ Prendergast, PJ Goulder |
Frontiers in immunology | 2014 |
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Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design
DK Wijesundara, Y Xi, C Ranasinghe |
Frontiers in immunology | 2014 |
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Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line
FQ He, U Sauermann, C Beer, S Winkelmann, Z Yu, S Sopper, AP Zeng, M Wirth |
Virology Journal | 2014 |
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Models for Predicting Effective HIV Chemoprevention in Women:
MR Nicol, CW Emerson, HM Prince, JA Nelson, Y Fedoriw, C Sykes, EJ Geller, KB Patterson, MS Cohen, AD Kashuba |
2014 | |
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The mixed blessing of interferon
A Telenti |
Nature | 2014 |
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Innate Immunity in Simian Immunodeficiency Virus Infection
Reeves RK, Bosinger SE |
Natural Hosts of SIV | 2014 |
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Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection.
Pulliam L |
Current HIV research | 2014 |
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Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection
M Kader, AP Smith, C Guiducci, ER Wonderlich, D Normolle, SC Watkins, FJ Barrat, SM Barratt-Boyes |
PLoS pathogens | 2013 |
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Therapeutic depletion of natural killer cells controls persistent infection
SN Waggoner, KA Daniels, RM Welsh |
Journal of virology | 2013 |
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Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers
XD Yao, RW Omange, BM Henrick, RT Lester, J Kimani, TB Ball, FA Plummer, KL Rosenthal |
Mucosal Immunology | 2013 |
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HIV-associated chronic immune activation
M Paiardini, M Müller-Trutwin |
Immunological Reviews | 2013 |
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Immune Activation and Collateral Damage in AIDS Pathogenesis
F Miedema, MD Hazenberg, K Tesselaar, D Baarle, RJ de Boer, JA Borghans |
Frontiers in immunology | 2013 |
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Immune restoration after antiretroviral therapy: the pitfalls of hasty or incomplete repairs
EM Wilson, I Sereti |
Immunological Reviews | 2013 |
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Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues
JD Estes |
Immunological Reviews | 2013 |
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Loss of memory CD4+ T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with species-specific simian immunodeficiency virus SIVmnd-1
EJ Greenwood, F Schmidt, F Liegeois, I Kondova, A Herbert, B Ngoubangoye, F Rouet, JL Heeney |
Journal of General Virology | 2013 |
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Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek, SG Deeks |
Immunological Reviews | 2013 |
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Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling
JR Teijaro, C Ng, AM Lee, BM Sullivan, KC Sheehan, M Welch, RD Schreiber, JC de la Torre, MB Oldstone |
Science | 2013 |
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Dendritic cell dysregulation during HIV-1 infection
E Miller, N Bhardwaj |
Immunological Reviews | 2013 |
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HIV-1 Infection of Plasmacytoid and Myeloid Dendritic Cells is Restricted by High Levels of SAMHD1 that Cannot be Counteracted by Vpx
N Bloch, M O'Brien, TD Norton, SB Polsky, N Bhardwaj, NR Landau |
AIDS Research and Human Retroviruses | 2013 |
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Immune Activation and the Role of TLRs and TLR Agonists in the Pathogenesis of HIV-1 Infection in the Humanized Mouse Model
JJ Chang, M Altfeld |
The Journal of Infectious Diseases | 2013 |
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Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1
A Boasso |
Scientifica | 2013 |
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Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
GA Hardy, S Sieg, B Rodriguez, D Anthony, R Asaad, W Jiang, J Mudd, T Schacker, NT Funderburg, HA Pilch-Cooper, R Debernardo, RL Rabin, MM Lederman, CV Harding |
PloS one | 2013 |
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Virus-encoded TLR ligands reveal divergent functional responses of mononuclear phagocytes in pathogenic simian immunodeficiency virus infection
ER Wonderlich, V Wijewardana, X Liu, SM Barratt-Boyes |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations
D Ma, A Jasinska, J Kristoff, JP Grobler, T Turner, Y Jung, C Schmitt, K Raehtz, F Feyertag, NM Sosa, V Wijewardana, DS Burke, DL Robertson, R Tracy, I Pandrea, N Freimer, C Apetrei, |
PLoS pathogens | 2013 |
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Link between Primate Lentiviral Coreceptor Usage and Nef Function
J Schmökel, H Li, A Shabir, H Yu, M Geyer, G Silvestri, DL Sodora, BH Hahn, F Kirchhoff |
Cell Reports | 2013 |
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NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections
RM Welsh, SN Waggoner |
Virology | 2013 |
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Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection
EB Wilson, DH Yamada, H Elsaesser, J Herskovitz, J Deng, G Cheng, BJ Aronow, CL Karp, DG Brooks |
Science | 2013 |
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Host–pathogen interaction in HIV infection
A Chowdhury, G Silvestri |
Current Opinion in Immunology | 2013 |
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Short Communication: HIV + Viremic Slow Progressors Maintain Low Regulatory T Cell Numbers in Rectal Mucosa but Exhibit High T Cell Activation
JM Shaw, PW Hunt, JW Critchfield, DH McConnell, JC Garcia, RB Pollard, M Somsouk, SG Deeks, BL Shacklett |
AIDS Research and Human Retroviruses | 2013 |
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Old world monkeys and new age science: the evolution of nonhuman primate systems virology
RE Palermo, J Tisoncik-Go, MJ Korth, MG Katze |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 2013 |
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Kinetics of myeloid dendritic cell trafficking and activation: impact on progressive, nonprogressive and controlled SIV infections
V Wijewardana, J Kristoff, C Xu, D Ma, G Haret-Richter, JL Stock, BB Policicchio, AD Mobley, R Nusbaum, H Aamer, A Trichel, RM Ribeiro, C Apetrei, I Pandrea |
PLoS pathogens | 2013 |
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Intact type I Interferon production and IRF7 function in sooty mangabeys
SE Bosinger, ZP Johnson, KA Folkner, N Patel, T Hashempour, SP Jochems, PM Estrada, M Paiardini, R Lin, TH Vanderford, J Hiscott, G Silvestri |
PLoS pathogens | 2013 |
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Interfering with type I interferon: a novel approach to purge persistent viral infection
EB Wilson, DG Brooks |
Cell cycle (Georgetown, Tex.) | 2013 |
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Differential type 1 interferon-regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence
MJ Polyak, P Vivithanaporn, FG Maingat, JG Walsh, W Branton, EA Cohen, R Meeker, C Power |
The FASEB Journal | 2013 |
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Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes
B Tavano, RP Galao, DR Graham, SJ Neil, VN Aquino, D Fuchs, A Boasso |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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SIV infection of rhesus macaques differentially impacts mononuclear phagocyte responses to virus-derived TLR agonists
ER Wonderlich, SM Barratt-Boyes |
2013 | |
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Decoding the complexity of type I interferon to treat persistent viral infections
EB Wilson, DG Brooks |
Trends in Microbiology | 2013 |
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The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression
MA O'Connor, WR Green |
Virology Journal | 2013 |
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The Oral Mucosa Immune Environment and Oral Transmission of HIV/SIV
LF Wood, A Chahroudi, HL Chen, HB Jaspan, DL Sodora |
Immunological Reviews | 2013 |
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Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10
P Verheugd, AH Forst, L Milke, N Herzog, KL Feijs, E Kremmer, H Kleine, B Lüscher |
Nature Communications | 2013 |
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PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
Ravi Dyavar, Vijayakumar Velu, Kehmia Titanji, Steven Bosinger, Gordon Freeman, Guido Silvestri, Rama Rao Amara |
Journal of Clinical Investigation | 2012 |
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Reduced Inflammation and Lymphoid Tissue Immunopathology in Rhesus Macaques Receiving Anti-Tumor Necrosis Factor Treatment During Primary Simian Immunodeficiency Virus Infection
B Tabb, DR Morcock, CM Trubey, OA Quinones, XP Hao, J Smedley, R Macallister, M Piatak, LD Harris, M Paiardini, G Silvestri, JM Brenchley, WG Alvord, JD Lifson, JD Estes |
The Journal of Infectious Diseases | 2012 |
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Natural SIV Hosts: Showing AIDS the Door
A Chahroudi, SE Bosinger, TH Vanderford, M Paiardini, G Silvestri |
Science | 2012 |
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The role of cytokines in the pathogenesis and treatment of HIV infection
M Catalfamo, CL Saout, HC Lane |
Cytokine & Growth Factor Reviews | 2012 |
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HIV Interactions with Dendritic Cells
L Wu, O Schwartz |
2012 | |
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HIV Interactions with Dendritic Cells
L Wu, O Schwartz |
2012 | |
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Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development
SM Keating, ES Jacobs, PJ Norris |
Cytokine & Growth Factor Reviews | 2012 |
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Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection
N Rout, J Greene, S Yue, D O'Connor, RP Johnson, JG Else, MA Exley, A Kaur |
PLoS pathogens | 2012 |
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Differential regulation of toll-like receptor pathways in acute and chronic HIV-1 infection :
JJ Chang, A Lacas, RJ Lindsay, EH Doyle, KL Axten, F Pereyra, ES Rosenberg, BD Walker, TM Allen, M Altfeld |
AIDS | 2012 |
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HIV-1 immunopathogenesis in humanized mouse models
L Zhang, L Su |
Cellular and Molecular Immunology | 2012 |
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Innate Immune Recognition of HIV-1
A Iwasaki |
Immunity | 2012 |
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Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers
JP Herbeuval, N Smith, J Thèze |
Clinical & developmental immunology | 2012 |
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Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype
O Manches, MV Fernandez, J Plumas, L Chaperot, N Bhardwaj |
Proceedings of the National Academy of Sciences | 2012 |
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Systems biology of natural simian immunodeficiency virus infections :
SE Bosinger, B Jacquelin, A Benecke, G Silvestri, M Müller-Trutwin |
Current Opinion in HIV and AIDS | 2012 |
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Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites
I Pandrea, NF Parrish, K Raehtz, T Gaufin, HJ Barbian, D Ma, J Kristoff, R Gautam, F Zhong, GS Haret-Richter, A Trichel, GM Shaw, BH Hahn, C Apetrei |
Journal of virology | 2012 |
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A dendrite in every pie
ER Wonderlich, SM Barratt-Boyes |
Virulence | 2012 |
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Double-negative T cells during HIV/SIV infections: Potential pinch hitters in the T cell lineup
V Sundaravaradan, KD Mir, DL Sodora |
Current Opinion in HIV and AIDS | 2012 |
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Evidence for a different susceptibility of primate lentiviruses to type I interferons
S Cordeil, XN Nguyen, G Berger, S Durand, M Ainouze, A Cimarelli |
Journal of virology | 2012 |
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Nonpathogenic Simian Immunodeficiency Virus Infections
NR Klatt, G Silvestri, V Hirsch |
Cold Spring Harbor Perspectives in Medicine | 2012 |
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Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge
M Genescà, ZM Ma, Y Wang, B Assaf, H Qureshi, L Fritts, Y Huang, MB McChesney, CJ Miller |
Journal of virology | 2012 |
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Systems Biology
MG Katze |
Systems Biology | 2012 |
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Host Genes Important to HIV Replication and Evolution
A Telenti, WE Johnson |
Cold Spring Harbor Perspectives in Medicine | 2012 |
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Dynamics of innate immunity are key to chronic immune activation in AIDS:
A Benecke, M Gale, MG Katze |
Current Opinion in HIV and AIDS | 2012 |
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Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection
AS Liovat, MA Rey-Cuillé, C Lécuroux, B Jacquelin, I Girault, G Petitjean, Y Zitoun, A Venet, F Barré-Sinoussi, P Lebon, L Meyer, M Sinet, M Müller-Trutwin |
PloS one | 2012 |
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Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation
TH Vanderford, C Slichter, KA Rogers, BO Lawson, R Obaede, J Else, F Villinger, SE Bosinger, G Silvestri |
Blood | 2012 |
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Dissecting the HIV-specific immune response: a systems biology approach
Y Peretz, C Cameron, RP Sékaly |
Current Opinion in HIV and AIDS | 2012 |
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Immune Activation in the Pathogenesis of Treated Chronic HIV Disease: A Workshop Summary
SF Plaeger, BS Collins, R Musib, SG Deeks, S Read, A Embry |
AIDS Research and Human Retroviruses | 2012 |
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Simian Immunodeficiency Virus-Induced Alterations in Monocyte Production of Tumor Necrosis Factor Alpha Contribute to Reduced Immune Activation in Sooty Mangabeys
KD Mir, SE Bosinger, M Gasper, O Ho, JG Else, JM Brenchley, DJ Kelvin, G Silvestri, S Hu, DL Sodora |
Journal of virology | 2012 |
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Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells
AG Drannik, K Nag, XD Yao, BM Henrick, TB Ball, FA Plummer, C Wachihi, J Kimani, KL Rosenthal |
PloS one | 2012 |
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Transcriptional profiling of experimental CD8(+) lymphocyte depletion in rhesus macaques infected with simian immunodeficiency virus SIVmac239
SE Bosinger, SP Jochems, KA Folkner, TL Hayes, NR Klatt, G Silvestri |
Journal of virology | 2012 |
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Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase
RM Dunham, SN Gordon, M Vaccari, M Piatak, Y Huang, SG Deeks, J Lifson, G Franchini, JM McCune |
AIDS Research and Human Retroviruses | 2012 |
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HIV and Inflammation: Mechanisms and Consequences
PW Hunt |
Current HIV/AIDS Reports | 2012 |
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Emerging Viral Infections
Osterhaus AD, Smits SL |
Genomic and Personalized Medicine | 2012 |
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Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype
Meagan O'Brien, Oliver Manches, Rachel Sabado, Sonia Jimenez Baranda, Yaming Wang, Isabelle Marie, Linda Rolnitzky, Martin Markowitz, David Margolis, David Levy, Nina Bhardwaj |
Journal of Clinical Investigation | 2011 |
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Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and sooty mangabey and rhesus macaque models of SIV infection
Margalida Rotger, Judith Dalmau, Andri Rauch, Paul McLaren, Steven Bosinger, Raquel Martinez, Netanya G. Sandler, Annelys Roque, Julia Liebner, Manuel Battegay, Enos Bernasconi, Patrick Descombes, Itziar Erkizia, Jacques Fellay, Bernard Hirschel, Jose M Miro, Eduard Palou, Matthias Hoffmann, MARTA MASSANELLA, JULIÀ BLANCO, Matthew Woods, Huldrych Guenthard, Paul de Bakker, Daniel Douek, Guido Silvestri, Javier Martinez-Picado, Amalio Telenti |
Journal of Clinical Investigation | 2011 |
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Type I Interferon Contributes to CD4+ T Cell Depletion Induced by Infection with HIV-1 in the Human Thymus▿
V Sivaraman, L Zhang, L Su |
Journal of virology | 2011 |
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Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques
S Kwa, S Kannanganat, P Nigam, M Siddiqui, RD Shetty, W Armstrong, A Ansari, SE Bosinger, G Silvestri, RR Amara |
Blood | 2011 |
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The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point?
PD Katsikis, YM Mueller, F Villinger |
PLoS pathogens | 2011 |
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A peripheral monocyte interferon phenotype in HIV infection correlates with a decrease in magnetic resonance spectroscopy metabolite concentrations :
L Pulliam, H Rempel, B Sun, L Abadjian, C Calosing, DJ Meyerhoff |
AIDS | 2011 |
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Dissecting the role of dendritic cells in simian immunodeficiency virus infection and AIDS
ER Wonderlich, M Kader, V Wijewardana, SM Barratt-Boyes |
Immunologic Research | 2011 |
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Innate sensing of HIV-infected cells
A Lepelley, S Louis, M Sourisseau, HK Law, J Pothlichet, C Schilte, L Chaperot, J Plumas, RE Randall, M Si-Tahar, F Mammano, ML Albert, O Schwartz |
PLoS pathogens | 2011 |
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Innate immunity in acute HIV-1 infection
P Borrow |
Current Opinion in HIV and AIDS | 2011 |
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Blocking Type I Interferon Production: A New Therapeutic Option to Reduce the HIV-1-Induced Immune Activation
M Ries, K Pritschet, B Schmidt |
Clinical and Developmental Immunology | 2011 |
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Grand Challenges in the Immunology of HIV and AIDS
F Miedema |
Frontiers in immunology | 2011 |
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Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis
A Boasso, CM Royle, S Doumazos, VN Aquino, M Biasin, L Piacentini, B Tavano, D Fuchs, F Mazzotta, SL Caputo, GM Shearer, M Clerici, DR Graham |
Blood | 2011 |
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DCs and NK cells: critical effectors in the immune response to HIV-1
M Altfeld, L Fadda, D Frleta, N Bhardwaj |
Nature reviews. Immunology | 2011 |
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CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques
JE Taaffe, SE Bosinger, GQ Prete, JG Else, S Ratcliffe, CD Ward, T Migone, M Paiardini, G Silvestri |
Journal of Medical Primatology | 2011 |
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Immunovirological Analyses of Chronically Simian Immunodeficiency Virus SIVmnd-1- and SIVmnd-2-Infected Mandrills (Mandrillus sphinx)
C Apetrei, B Sumpter, S Souquiere, A Chahroudi, M Makuwa, P Reed, RM Ribeiro, I Pandrea, P Roques, G Silvestri |
Journal of virology | 2011 |
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SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase
KD Mir, MA Gasper, V Sundaravaradan, DL Sodora |
Microbes and Infection | 2011 |
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Generalized immune activation and innate immune responses in SIV infection
SE Bosinger, DL Sodora, G Silvestri |
Current Opinion in HIV and AIDS | 2011 |
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Innate and adaptive immune responses both contribute to pathological CD4 T cell activation in HIV-1 infected Ugandans
MA Eller, KG Blom, VD Gonzalez, LA Eller, P Naluyima, O Laeyendecker, TC Quinn, N Kiwanuka, D Serwadda, NK Sewankambo, B Tasseneetrithep, MJ Wawer, RH Gray, MA Marovich, NL Michael, MS de Souza, F Wabwire-Mangen, ML Robb, JR Currier, JK Sandberg |
PloS one | 2011 |
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Negative regulation of interferon-β gene expression during acute and persistent virus infections
J Ye, T Maniatis |
PloS one | 2011 |
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The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature
AK Morou, F Porichis, E Krambovitis, G Sourvinos, DA Spandidos, A Zafiropoulos |
Journal of Translational Medicine | 2011 |
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A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques
SM Barratt-Boyes, V Wijewardana |
Journal of Medical Primatology | 2011 |
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Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals
RC Su, A Sivro, J Kimani, W Jaoko, FA Plummer, TB Ball |
Blood | 2011 |
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The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women
SM Keating, ET Golub, M Nowicki, M Young, K Anastos, H Crystal, MH Cohen, J Zhang, RM Greenblatt, S Desai, S Wu, AL Landay, SJ Gange, PJ Norris, |
AIDS | 2011 |
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Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic HIV-1 Infection
A Haas, K Zimmermann, A Oxenius |
Journal of virology | 2011 |
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CD4 and CD8 T Cell Immune Activation during Chronic HIV Infection: Roles of Homeostasis, HIV, Type I IFN, and IL-7
M Catalfamo, C Wilhelm, L Tcheung, M Proschan, T Friesen, JH Park, J Adelsberger, M Baseler, F Maldarelli, R Davey, G Roby, C Rehm, C Lane |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Early Induction of Polyfunctional Simian Immunodeficiency Virus (SIV)-Specific T Lymphocytes and Rapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys during Primary Infection
M Meythaler, Z Wang, A Martinot, S Pryputniewicz, M Kasheta, HM McClure, SP ONeil, A Kaur |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands
W Jennes, S Verheyden, C Demanet, J Menten, B Vuylsteke, JN Nkengasong, L Kestens |
PloS one | 2011 |
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Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression
M Paiardini, B Cervasi, E Reyes-Aviles, L Micci, AM Ortiz, A Chahroudi, C Vinton, SN Gordon, SE Bosinger, N Francella, PL Hallberg, E Cramer, T Schlub, ML Chan, NE Riddick, RG Collman, C Apetrei, I Pandrea, J Else, J Munch, F Kirchhoff, MP Davenport, JM Brenchley, G Silvestri |
Nature Medicine | 2011 |
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Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge
LJ Patterson, M Daltabuit-Test, P Xiao, J Zhao, W Hu, U Wille-Reece, E Brocca-Cofano, VS Kalyanaraman, I Kalisz, S Whitney, EM Lee, R Pal, DC Montefiori, S Dandekar, R Seder, M Roederer, RW Wiseman, V Hirsch, M Robert-Guroff |
Virology | 2011 |
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EBV-specific CD8+ T cells from asymptomatic pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function
C Macedo, SA Webber, AD Donnenberg, I Popescu, Y Hua, M Green, D Rowe, L Smith, MM Brooks, D Metes |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Mother-to-Infant Transmission of Simian Immunodeficiency Virus Is Rare in Sooty Mangabeys and Is Associated with Low Viremia
A Chahroudi, T Meeker, B Lawson, S Ratcliffe, J Else, G Silvestri |
Journal of virology | 2011 |
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Mechanisms of HIV-associated lymphocyte apoptosis: 2010
NW Cummins, AD Badley |
Cell Death and Disease | 2010 |
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Innate immunity against HIV: a priority target for HIV prevention research
P Borrow, RJ Shattock, A Vyakarnam |
Retrovirology | 2010 |
|
Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
LG Zhang, E Meissner, JZ Chen, LS Su |
Science China Life Sciences | 2010 |
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Innate immune recognition and activation during HIV infection
TH Mogensen, J Melchjorsen, CS Larsen, SR Paludan |
Retrovirology | 2010 |
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In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization
SM Barratt-Boyes, V Wijewardana, KN Brown |
Journal of Medical Primatology | 2010 |
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Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections
JM Brenchley, G Silvestri, DC Douek |
Immunity | 2010 |
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A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo
NE Riddick, EA Hermann, LM Loftin, ST Elliott, WC Wey, B Cervasi, J Taaffe, JC Engram, B Li, JG Else, Y Li, BH Hahn, CA Derdeyn, DL Sodora, C Apetrei, M Paiardini, G Silvestri, RG Collman |
PLoS pathogens | 2010 |
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A Five-Year Longitudinal Analysis of Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus Reveals a Slow but Progressive Decline in CD4 + T-Cell Count Whose Magnitude Is Not Predicted by Viral Load or Immune Activation
J Taaffe, A Chahroudi, J Engram, B Sumpter, T Meeker, S Ratcliffe, M Paiardini, J Else, G Silvestri |
Journal of virology | 2010 |
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Innate Immune Activation in Primary HIV-1 Infection
JJ Chang, M Altfeld |
The Journal of Infectious Diseases | 2010 |
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The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses
J Schmökel, D Sauter, M Schindler, FH Leendertz, E Bailes, MC Dazza, S Saragosti, F Bibollet-Ruche, M Peeters, BH Hahn, F Kirchhoff |
Journal of virology | 2010 |
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Genetic Identity and Biological Phenotype of a Transmitted/Founder Virus Representative of Nonpathogenic Simian Immunodeficiency Virus Infection in African Green Monkeys
CW Gnanadurai, I Pandrea, NF Parrish, MH Kraus, GH Learn, MG Salazar, U Sauermann, K Töpfer, R Gautam, J Münch, C Stahl-Hennig, C Apetrei, BH Hahn, F Kirchhoff |
Journal of virology | 2010 |
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Transcriptional Profiling of CD4 T Cells Identifies Distinct Subgroups of HIV-1 Elite Controllers
F Vigneault, M Woods, MJ Buzon, C Li, F Pereyra, SD Crosby, J Rychert, G Church, J Martinez-Picado, ES Rosenberg, A Telenti, XG Yu, M Lichterfeld |
Journal of virology | 2010 |
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Genomic analysis reveals pre- and postchallenge differences in a rhesus macaque AIDS vaccine trial: insights into mechanisms of vaccine efficacy
RE Palermo, LJ Patterson, LD Aicher, MJ Korth, M Robert-Guroff, MG Katze |
Journal of virology | 2010 |
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Host genetics and HIV-1: the final phase?
J Fellay, KV Shianna, A Telenti, DB Goldstein |
PLoS pathogens | 2010 |
|
Identifying and characterizing recently transmitted viruses
BF Keele |
Current Opinion in HIV and AIDS | 2010 |
|
Plasmacytoid dendritic cells in antiviral immunity and autoimmunity
F Tang, Q Du, YJ Liu |
Science China Life Sciences | 2010 |
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Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques
LD Harris, B Tabb, DL Sodora, M Paiardini, NR Klatt, DC Douek, G Silvestri, M Müller-Trutwin, I Vasile-Pandrea, C Apetrei, V Hirsch, J Lifson, JM Brenchley, JD Estes |
Journal of virology | 2010 |
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Host adaptive immunity deficiency in severe pandemic influenza
JF Bermejo-Martin, I Martin-Loeches, J Rello, A Antón, R Almansa, L Xu, G Lopez-Campos, T Pumarola, L Ran, P Ramirez, D Banner, DC Ng, L Socias, A Loza, D Andaluz, E Maravi, MJ Gómez-Sánchez, M Gordón, MC Gallegos, V Fernandez, S Aldunate, C León, P Merino, J Blanco, F Martin-Sanchez, L Rico, D Varillas, V Iglesias, MÁ Marcos, F Gandía, F Bobillo, B Nogueira, S Rojo, S Resino, C Castro, RO de Lejarazu, D Kelvin |
Critical Care | 2010 |
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Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation
A Danesh, CM Cameron, AJ León, L Ran, L Xu, Y Fang, AA Kelvin, T Rowe, H Chen, Y Guan, CB Jonsson, MJ Cameron, DJ Kelvin |
Virology | 2010 |
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Strong but Rapidly Controlled Interferon Type I Response in Nonpathogenic SIV Infection of African Green Monkeys
Beatrice JACQUELIN, Véronique MAYAU, Brice Targat, Anne-Sophie Liovat, Désirée Kunkel, Gaël Petitjean, Marie-Agnès Dillies, Pierre Roques, Cécile Butor, Guido Silvestri, Luis D. Giavedoni, Pierre Lebon, Françoise Barré-Sinoussi, Arndt Benecke, Michaela Müller-Trutwin |
Journal of Clinical Investigation | 2009 |
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Resolution of immune activation defines non-pathogenic SIV infection
Nina Bhardwaj, Oliver Manches |
Journal of Clinical Investigation | 2009 |
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