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Pervinder Sagoo, … , Maria P. Hernandez-Fuentes, Robert I. Lechler
Published May 24, 2010
Citation Information: J Clin Invest. 2010;120(6):1848-1861. https://doi.org/10.1172/JCI39922.
Citation Information: J Clin Invest. 2010;120(6):1848-1861. https://doi.org/10.1172/JCI39922.
Abstract
Identifying transplant recipients in whom immunological tolerance is established or is developing would allow an individually tailored approach to their posttransplantation management. In this study, we aimed to develop reliable and reproducible in vitro assays capable of detecting tolerance in renal transplant recipients. Several biomarkers and bioassays were screened on a training set that included 11 operationally tolerant renal transplant recipients, recipient groups following different immunosuppressive regimes, recipients undergoing chronic rejection, and healthy controls. Highly predictive assays were repeated on an independent test set that included 24 tolerant renal transplant recipients. Tolerant patients displayed an expansion of peripheral blood B and NK lymphocytes, fewer activated CD4+ T cells, a lack of donor-specific antibodies, donor-specific hyporesponsiveness of CD4+ T cells, and a high ratio of forkhead box P3 to α-1,2-mannosidase gene expression. Microarray analysis further revealed in tolerant recipients a bias toward differential expression of B cell–related genes and their associated molecular pathways. By combining these indices of tolerance as a cross-platform biomarker signature, we were able to identify tolerant recipients in both the training set and the test set. This study provides an immunological profile of the tolerant state that, with further validation, should inform and shape drug-weaning protocols in renal transplant recipients.
Authors
Pervinder Sagoo, Esperanza Perucha, Birgit Sawitzki, Stefan Tomiuk, David A. Stephens, Patrick Miqueu, Stephanie Chapman, Ligia Craciun, Ruhena Sergeant, Sophie Brouard, Flavia Rovis, Elvira Jimenez, Amany Ballow, Magali Giral, Irene Rebollo-Mesa, Alain Le Moine, Cecile Braudeau, Rachel Hilton, Bernhard Gerstmayer, Katarzyna Bourcier, Adnan Sharif, Magdalena Krajewska, Graham M. Lord, Ian Roberts, Michel Goldman, Kathryn J. Wood, Kenneth Newell, Vicki Seyfert-Margolis, Anthony N. Warrens, Uwe Janssen, Hans-Dieter Volk, Jean-Paul Soulillou, Maria P. Hernandez-Fuentes, Robert I. Lechler
Total citations by year
Citation information
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Transplant International | 2017 |
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Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses
AT Brinke, N Marek-Trzonkowska, MJ Mansilla, AW Turksma, K Piekarska, D Iwaszkiewicz-Grześ, L Passerini, G Locafaro, J Puñet-Ortiz, SM van Ham, MP Hernandez-Fuentes, EM Martínez-Cáceres, S Gregori |
Frontiers in immunology | 2017 |
|
Reduced TCR-signalling contributes to impaired Th17 responses in tolerant kidney transplant recipients:
E Nova-Lamperti, M Romano, S Christakoudi, M Runglall, R McGregor, P Mobillo, Y Kamra, TL Tsui, S Norris, S John, DA Boardman, RI Lechler, G Lombardi, MP Hernandez-Fuentes |
Transplantation | 2017 |
|
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation
L Gallon, JM Mathew, SV Bontha, CI Dumur, P Dalal, L Nadimpalli, DG Maluf, AA Shetty, ST Ildstad, JR Leventhal, VR Mas |
Journal of the American Society of Nephrology : JASN | 2017 |
|
The Use of Genomics and Pathway Analysis in Our Understanding and Prediction of Clinical Renal Transplant Injury:
MC Menon, KL Keung, B Murphy, PJ OʼConnell |
Transplantation | 2016 |
|
Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis
SE Andersson, T Eneljung, S Tengvall, P Jirholt, A Stern, L Henningsson, B Liang, K Thorarinsdottir, J Kihlberg, R Holmdahl, IL Mårtensson, K Gustafsson, I Gjertsson |
Arthritis Research & Therapy | 2016 |
|
Transplantation Tolerance Induction: Cell Therapies and Their Mechanisms
JR Scalea, Y Tomita, CR Lindholm, W Burlingham |
Frontiers in immunology | 2016 |
|
Erosion of Transplantation Tolerance After Infection
JS Young, MD Daniels, ML Miller, T Wang, R Zhong, D Yin, ML Alegre, AS Chong |
American Journal of Transplantation | 2016 |
|
Tolerance in liver transplantation: Biomarkers and clinical relevance
A Baroja-Mazo, B Revilla-Nuin, P Parrilla, L Martínez-Alarcón, P Ramírez, JA Pons |
World journal of gastroenterology : WJG | 2016 |
|
Mass cytometry reveals a distinct immunoprofile of operational tolerance in pediatric liver transplantation
AH Lau, MJ Vitalone, K Haas, T Shawler, CO Esquivel, WE Berquist, OM Martinez, RO Castillo, SM Krams |
Pediatric Transplantation | 2016 |
|
Effect of Immunosuppressive Drugs on Humoral Allosensitization after Kidney Transplant
O Thaunat, A Koenig, C Leibler, P Grimbert |
Journal of the American Society of Nephrology : JASN | 2016 |
|
Increased CD40 ligation and reduced BCR signalling leads to higher IL-10 production in B cells from tolerant kidney transplant patients:
E Nova-Lamperti, P Chana, P Mobillo, M Runglall, Y Kamra, R McGregor, GM Lord, RI Lechler, G Lombardi, MP Hernandez-Fuentes |
Transplantation | 2016 |
|
Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?
I Rebollo-Mesa, E Nova-Lamperti, P Mobillo, M Runglall, S Christakoudi, S Norris, N Smallcombe, Y Kamra, R Hilton, S Bhandari, R Baker, D Berglund, S Carr, D Game, S Griffin, PA Kalra, R Lewis, PB Mark, S Marks, I Macphee, W McKane, MG Mohaupt, R Pararajasingam, SP Kon, D Serón, MD Sinha, B Tucker, O Viklický, RI Lechler, GM Lord, MP Hernandez-Fuentes |
American Journal of Transplantation | 2016 |
|
IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses
E Nova-Lamperti, G Fanelli, PD Becker, P Chana, R Elgueta, PC Dodd, GM Lord, G Lombardi, MP Hernandez-Fuentes |
Scientific Reports | 2016 |
|
A New Window into the Human Alloresponse:
S DeWolf, Y Shen, M Sykes |
Transplantation | 2016 |
|
Quantification of CD4 + T Cell Alloreactivity and Its Control by Regulatory T Cells Using Time-Lapse Microscopy and Immune Synapse Detection
SC Juvet, S Sanderson, J Hester, KJ Wood, A Bushell |
American Journal of Transplantation | 2016 |
|
Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation
J Yang, J Chen, JS Young, Q Wang, D Yin, R Sciammas, AS Chong |
Transplantation | 2016 |
|
Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates
JM Yabu, JC Siebert, HT Maecker, S Stepkowski |
PloS one | 2016 |
|
Renal Transplant Recipients Treated with Calcineurin-Inhibitors Lack Circulating Immature Transitional CD19+CD24hiCD38hi Regulatory B-Lymphocytes
B Tebbe, B Wilde, Z Ye, J Wang, X Wang, F Jian, S Dolff, M Schedlowski, PF Hoyer, A Kribben, O Witzke, A Hoerning, S Stepkowski |
PloS one | 2016 |
|
Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs
A Koenig, O Thaunat |
Frontiers in immunology | 2016 |
|
The Effect of Histological CD20-Positive B Cell Infiltration in Acute Cellular Rejection on Kidney Transplant Allograft Survival
Y Jiang, R Wang, H Wang, H Huang, W Peng, W Qiu, J Zhou, J Chen |
Journal of Immunology Research | 2016 |
|
Tolerance in Kidney Transplantation: What Is on the B Side?
L Carreras-Planella, FE Borràs, M Franquesa |
Mediators of Inflammation | 2016 |
|
Transplantology: Challenges for Today
M Boratyńska, D Patrzałek |
Archivum Immunologiae et Therapiae Experimentalis | 2016 |
|
B cells with regulatory properties in transplantation tolerance
J Durand |
World Journal of Transplantation | 2015 |
|
Cellular immune profile of kidney transplant patients developing anti-HLA antibodies during childhood
V Santilli, A Cagigi, I Guzzo, S Rinaldi, N Mora, F Zotta, A Piazza, P Rossi, F Emma, LD Strologo, P Palma |
Pediatric Nephrology | 2015 |
|
Cell Therapy to Induce Allograft Tolerance: Time to Switch to Plan B?
A Sicard, A Koenig, E Morelon, T Defrance, O Thaunat |
Frontiers in immunology | 2015 |
|
B Cells, Antibodies, and More
W Hoffman, FG Lakkis, G Chalasani |
Clinical journal of the American Society of Nephrology : CJASN | 2015 |
|
Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation
C McDonald-Hyman, LA Turka, BR Blazar |
Science Translational Medicine | 2015 |
|
CD8+ Immunosenescence Predicts Post-Transplant Cutaneous Squamous Cell Carcinoma in High-Risk Patients
MJ Bottomley, PN Harden, KJ Wood |
Journal of the American Society of Nephrology : JASN | 2015 |
|
Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation
N Safinia, C Scotta, T Vaikunthanathan, RI Lechler, G Lombardi |
Frontiers in immunology | 2015 |
|
Fibrinogen-Like Protein 2/Fibroleukin Induces Long-Term Allograft Survival in a Rat Model through Regulatory B Cells
S Bézie, E Picarda, L Tesson, K Renaudin, J Durand, S Ménoret, E Mérieau, E Chiffoleau, C Guillonneau, L Caron, I Anegon, L Chatenoud |
PloS one | 2015 |
|
Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance
F Braza, E Dugast, I Panov, C Paul, K Vogt, A Pallier, M Chesneau, D Baron, P Guerif, H Lei, DA Laplaud, HD Volk, N Degauque, M Giral, JP Soulillou, B Sawitzki, S Brouard |
Journal of the American Society of Nephrology : JASN | 2015 |
|
Role of B cells in tolerance induction:
JI Kim, DM Rothstein, JF Markmann |
Current Opinion in Organ Transplantation | 2015 |
|
Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model
R Alhabbab, P Blair, R Elgueta, E Stolarczyk, E Marks, PD Becker, K Ratnasothy, L Smyth, N Safinia, E Sharif-Paghaleh, S O’Connell, RJ Noelle, GM Lord, JK Howard, J Spencer, RI Lechler, G Lombardi |
Scientific Reports | 2015 |
|
Emergent Transcriptomic Technologies and Their Role in the Discovery of Biomarkers of Liver Transplant Tolerance
S Mastoridis, M Martínez-Llordella, A Sanchez-Fueyo |
Frontiers in immunology | 2015 |
|
Tolerance signatures in transplant recipients:
KA Newell, LA Turka |
Current Opinion in Organ Transplantation | 2015 |
|
Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients
E Dumontet, R Danger, PA Vagefi, MC Londoño, A Pallier, JJ Lozano, M Giral, N Degauque, JP Soulillou, M Martínez-Llordella, H Lee, M Latournerie, K Boudjema, J Dulong, K Tarte, A Sanchez-Fueyo, S Feng, S Brouard, S Conchon |
Liver International | 2015 |
|
NK Cells of Kidney Transplant Recipients Display an Activated Phenotype that Is Influenced by Immunosuppression and Pathological Staging
U Hoffmann, C Neudörfl, K Daemen, J Keil, M Stevanovic-Meyer, F Lehner, H Haller, C Blume, CS Falk, JK Sandberg |
PloS one | 2015 |
|
A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft
D Baron, G Ramstein, M Chesneau, Y Echasseriau, A Pallier, C Paul, N Degauque, MP Hernandez-Fuentes, A Sanchez-Fueyo, KA Newell, M Giral, JP Soulillou, R Houlgatte, S Brouard |
Kidney International | 2015 |
|
Establishment of a Global Virtual Laboratory for Transplantation: A Symposium Report
EK Geissler, SG Tullius, AS Chong |
Transplantation | 2015 |
|
Immune biomarkers: the promises and pitfalls of personalized medicine
JC Willis, GM Lord |
Nature Reviews Immunology | 2015 |
|
B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection
KY Shiu, L McLaughlin, I Rebollo-Mesa, J Zhao, V Semik, HT Cook, C Roufosse, P Brookes, RW Bowers, J Galliford, D Taube, RI Lechler, MP Hernandez-Fuentes, A Dorling |
Kidney International | 2015 |
|
Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance:
G Lal, Y Nakayama, A Sethi, AK Singh, BE Burrell, N Kulkarni, CC Brinkman, D Iwami, T Zhang, JS Bromberg |
Transplantation | 2015 |
|
Spontaneous restoration of transplantation tolerance after acute rejection
ML Miller, MD Daniels, T Wang, J Chen, J Young, J Xu, Y Wang, D Yin, V Vu, AN Husain, ML Alegre, AS Chong |
Nature Communications | 2015 |
|
Rejection triggers liver transplant tolerance: Involvement of mesenchyme-mediated immune control mechanisms in mice: HEPATOLOGY, Vol. XX, No. X, 2015
M Morita, D Joyce, C Miller, JJ Fung, L Lu, S Qian |
Hepatology | 2015 |
|
Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance
E Krepsova, I Tycova, A Sekerkova, P Wohlfahrt, P Hruba, I Striz, B Sawitzki, O Viklicky |
BMC Nephrology | 2015 |
|
Longitudinal Studies of a B Cell-Derived Signature of Tolerance in Renal Transplant Recipients: B Cell Biomarkers of Renal Allograft Tolerance
KA Newell, A Asare, I Sanz, C Wei, A Rosenberg, Z Gao, S Kanaparthi, S Asare, N Lim, M Stahly, M Howell, S Knechtle, A Kirk, WH Marks, T Kawai, T Spitzer, N Tolkoff-Rubin, M Sykes, DH Sachs, AB Cosimi, WJ Burlingham, D Phippard, LA Turka |
American Journal of Transplantation | 2015 |
|
Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties
M Chesneau, L Michel, E Dugast, A Chenouard, D Baron, A Pallier, J Durand, F Braza, P Guerif, DA Laplaud, JP Soulillou, M Giral, N Degauque, E Chiffoleau, S Brouard |
Journal of the American Society of Nephrology : JASN | 2015 |
|
Adverse Outcomes of Tacrolimus Withdrawal in Immune-Quiescent Kidney Transplant Recipients
DE Hricik, RN Formica, P Nickerson, D Rush, RL Fairchild, ED Poggio, IW Gibson, C Wiebe, K Tinckam, S Bunnapradist, M Samaniego-Picota, DC Brennan, B Schroppel, O Gaber, B Armstrong, D Ikle, H Diop, ND Bridges, PS Heeger |
Journal of the American Society of Nephrology : JASN | 2015 |
|
Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells
R Bacchetta, B Lucarelli, C Sartirana, S Gregori, MT Stanghellini, P Miqueu, S Tomiuk, M Hernandez-Fuentes, ME Gianolini, R Greco, M Bernardi, E Zappone, S Rossini, U Janssen, A Ambrosi, M Salomoni, J Peccatori, F Ciceri, MG Roncarolo |
Frontiers in immunology | 2014 |
|
Transplantation tolerance and its outcome during infections and inflammation
AS Chong, ML Alegre |
Immunological Reviews | 2014 |
|
The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts
P Urbanellis, W Shyu, R Khattar, J Wang, A Zakharova, W He, H Sadozai, AZ Amir, I Shalev, MJ Phillips, O Adeyi, H Ross, D Grant, GA Levy, A Chruscinski |
Immunology | 2014 |
|
Lung transplantation: Chronic allograft dysfunction and establishing immune tolerance
AS Gracon, DS Wilkes |
Human Immunology | 2014 |
|
Recipients with in utero induction of tolerance upregulated MHC class I in the engrafted donor skin
JC Chen, LS Ou, HY Yu, ML Kuo, PY Chang, HL Chang |
Disease Markers | 2014 |
|
A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation
S Roedder, L Li, MN Alonso, SC Hsieh, MT Vu, H Dai, TK Sigdel, I Bostock, C Macedo, D Metes, A Zeevi, R Shapiro, O Salvatierra, J Scandling, J Alberu, E Engleman, MM Sarwal |
Journal of the American Society of Nephrology : JASN | 2014 |
|
Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients
PF Halloran, J Chang, K Famulski, LG Hidalgo, ID Salazar, MM Lopez, A Matas, M Picton, D Freitas, J Bromberg, D Seron, J Sellares, G Einecke, J Reeve |
Journal of the American Society of Nephrology : JASN | 2014 |
|
Immunologic Human Renal Allograft Injury Associates with an Altered IL-10/TNF- Expression Ratio in Regulatory B Cells
A Cherukuri, DM Rothstein, B Clark, CR Carter, A Davison, M Hernandez-Fuentes, E Hewitt, AD Salama, RJ Baker |
Journal of the American Society of Nephrology : JASN | 2014 |
|
Prevention of Graft-versus-Host Disease by Adoptive T Regulatory Therapy Is Associated with Active Repression of Peripheral Blood Toll-Like Receptor 5 mRNA Expression
B Sawitzki, C Brunstein, C Meisel, J Schumann, K Vogt, C Appelt, JM Curtsinger, MR Verneris, JS Miller, JE Wagner, BR Blazar |
Biology of Blood and Marrow Transplantation | 2014 |
|
Distinct cytokines balance the development of regulatory T cells and interleukin-10-producing regulatory B cells
V Holan, A Zajicova, E Javorkova, P Trosan, M Chudickova, M Pavlikova, M Krulova |
Immunology | 2014 |
|
B cells with immune-regulating function in transplantation
J Stolp, LA Turka, KJ Wood |
Nature Reviews Nephrology | 2014 |
|
Biomarkers for kidney transplant rejection
DJ Lo, B Kaplan, AD Kirk |
Nature Reviews Nephrology | 2014 |
|
Two-stage, in silico deconvolution of the lymphocyte compartment of the peripheral whole blood transcriptome in the context of acute kidney allograft rejection
CP Shannon, R Balshaw, RT Ng, JE Wilson-McManus, P Keown, R McMaster, BM McManus, D Landsberg, NM Isbel, G Knoll, SJ Tebbutt |
PloS one | 2014 |
|
Flow Cytometry and Solid Organ Transplantation: A Perfect Match
O Maguire, JD Tario, TC Shanahan, PK Wallace, H Minderman |
Immunological Investigations | 2014 |
|
Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials
M Letzkus, E Luesink, S Starck-Schwertz, M Bigaud, F Mirza, N Hartmann, B Gerstmayer, U Janssen, A Scherer, MM Schumacher, A Verles, A Vitaliti, N Nirmala, KJ Johnson, F Staedtler |
Clinical and Translational Medicine | 2014 |
|
Antibody-mediated rejection in young kidney transplant recipients: the dilemma of noncompliance and insufficient immunosuppression
O Bestard, MM Sarwal |
Pediatric Nephrology | 2014 |
|
Methodological aspects of anti-human leukocyte antigen antibody analysis in solid organ transplantation
AL Lobashevsky |
World Journal of Transplantation | 2014 |
|
B Cells and Kidney Transplantation: Beyond Antibodies
A Mehrotra, PS Heeger |
Journal of the American Society of Nephrology : JASN | 2014 |
|
Long-term outcomes of children after solid organ transplantation
Kim JJ, Marks SD |
Clinics | 2014 |
|
Heart grafts tolerized through third-party multipotent adult progenitor cells can be retransplanted to secondary hosts with no immunosuppression
E Eggenhofer, FC Popp, M Mendicino, P Silber, WV Hof, P Renner, MJ Hoogduijn, J Pinxteren, N Rooijen, EK Geissler, R Deans, HJ Schlitt, MH Dahlke |
Stem Cells Translational Medicine | 2013 |
|
Effector Mechanisms of Rejection
A Moreau, E Varey, I Anegon, MC Cuturi |
Cold Spring Harbor Perspectives in Medicine | 2013 |
|
Regulatory Cells and Transplantation Tolerance
SP Cobbold, H Waldmann |
Cold Spring Harbor Perspectives in Medicine | 2013 |
|
Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation
G Vassalli |
Journal of Transplantation | 2013 |
|
A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients’ CD8 T Cells
L Ordonez, I Bernard, M Chabod, JF Augusto, V Lauwers-Cances, C Cristini, MC Cuturi, JF Subra, A Saoudi, K Tasken |
PloS one | 2013 |
|
Promoting transplantation tolerance; adoptive regulatory T cell therapy
N Safinia, J Leech, M Hernandez-Fuentes, R Lechler, G Lombardi |
Clinical & Experimental Immunology | 2013 |
|
Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients
DS Segundo, MÁ Ballesteros, S Naranjo, F Zurbano, E Miñambres, M López-Hoyos |
PloS one | 2013 |
|
Regulatory B cells and tolerance in transplantation: from animal models to human
M Chesneau, L Michel, N Degauque, S Brouard |
Frontiers in immunology | 2013 |
|
Immunologic monitoring in kidney transplant recipients
N Townamchai, K Safa, A Chandraker |
Kidney Research and Clinical Practice | 2013 |
|
Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials: Regulatory T cells from uraemic patients
D Berglund, M Karlsson, AR Biglarnia, T Lorant, G Tufveson, O Korsgren, B Carlsson |
Clinical & Experimental Immunology | 2013 |
|
Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study
M Streitz, T Miloud, M Kapinsky, MR Reed, R Magari, EK Geissler, JA Hutchinson, K Vogt, S Schlickeiser, AH Kverneland, C Meisel, HD Volk, B Sawitzki |
Transplantation Research | 2013 |
|
Transplantation tolerance
EM Salisbury, DS Game, RI Lechler |
Pediatric Nephrology | 2013 |
|
B-cell-mediated strategies to fight chronic allograft rejection
A Dalloul |
Frontiers in immunology | 2013 |
|
A decision theory paradigm for evaluating identifier mapping and filtering methods using data integration
RS Day, KK McDade |
BMC bioinformatics | 2013 |
|
Integration of lyoplate based flow cytometry and computational analysis for standardized immunological biomarker discovery
F Villanova, PD Meglio, M Inokuma, N Aghaeepour, E Perucha, J Mollon, L Nomura, M Hernandez-Fuentes, A Cope, AT Prevost, S Heck, V Maino, G Lord, RR Brinkman, FO Nestle |
PloS one | 2013 |
|
Peripheral regulatory cells immunophenotyping in primary Sjögren's syndrome: a cross-sectional study
J Furuzawa-Carballeda, G Hernández-Molina, G Lima, Y Rivera-Vicencio, K Férez-Blando, L Llorente |
Arthritis Research & Therapy | 2013 |
|
Reconsidering the bio-detection of tolerance in renal transplantation
F Braza, JP Soulillou, S Brouard |
Chimerism | 2013 |
|
The Peripheral NK Cell Repertoire after Kidney Transplantation is Modulated by Different Immunosuppressive Drugs
C Neudoerfl, BJ Mueller, C Blume, K Daemen, M Stevanovic-Meyer, J Keil, F Lehner, H Haller, CS Falk |
Frontiers in immunology | 2013 |
|
Tolerance--Is It Worth It?
EB Finger, TB Strom, AJ Matas |
Cold Spring Harbor Perspectives in Medicine | 2013 |
|
The Paradoxical Functions of B Cells and Antibodies in Transplantation
MI Cascalho, BJ Chen, M Kain, JL Platt |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
IFN-γ-induced iNOS Expression in Mouse Regulatory Macrophages Prolongs Allograft Survival in Fully Immunocompetent Recipients
P Riquelme, S Tomiuk, A Kammler, F Fändrich, HJ Schlitt, EK Geissler, JA Hutchinson |
Molecular Therapy | 2012 |
|
Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers
ME Himmel, Y Yao, PC Orban, TS Steiner, MK Levings |
Immunology | 2012 |
|
Individualized immunosuppression in transplant patients: potential role of pharmacogenetics
H Abboudi, IA Macphee |
Pharmacogenomics and Personalized Medicine | 2012 |
|
Biomarkers of operational tolerance in solid organ transplantation
S Heidt, KJ Wood |
Expert Opinion on Medical Diagnostics | 2012 |
|
The impact of infection and tissue damage in solid-organ transplantation
AS Chong, ML Alegre |
Nature Reviews Immunology | 2012 |
|
Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation
P Sagoo, G Lombardi, RI Lechler |
Frontiers in immunology | 2012 |
|
Translating tolerogenic therapies to the clinic – where do we stand?
F Issa, KJ Wood |
Frontiers in immunology | 2012 |
|
Regulatory immune cells in transplantation
KJ Wood, A Bushell, J Hester |
Nature Reviews Immunology | 2012 |
|
Tolerance after Solid Organ and Hematopoietic Cell Transplantation
P Szabolcs, WJ Burlingham, AW Thomson |
Biology of Blood and Marrow Transplantation | 2012 |
|
NK Cells are Required for Costimulatory Blockade Induced Tolerance to Vascularized Allografts:
W der Touw, B Burrell, G Lal, JS Bromberg |
Transplantation | 2012 |
|
B-cell depletion improves islet allograft survival with anti-CD45RB
KM Lee, H Yeh, G Zhao, L Wei, M O'Connor, RT Stott, J Soohoo, K Dunussi, P Fiorina, S Deng, JF Markmann, JI Kim |
Cell Transplantation | 2012 |
|
A New Paradigm for an Old Story: The Role of Regulatory B Cells in Cancer
A Biragyn, C Lee-Chang |
Frontiers in immunology | 2012 |
|
Tolerogenic therapies in transplantation
EK Page, WA Dar, SJ Knechtle |
Frontiers in immunology | 2012 |
|
Immunomodulatory Effect of Mesenchymal Stem Cells on B Cells
M Franquesa, MJ Hoogduijn, O Bestard, JM Grinyó |
Frontiers in immunology | 2012 |
|
B Cell Repopulation After Alemtuzumab Induction—Transient Increase in Transitional B Cells and Long-Term Dominance of Naïve B Cells
S Heidt, J Hester, S Shankar, PJ Friend, KJ Wood |
American Journal of Transplantation | 2012 |
|
Role of ELISPOT Assays in Risk Assessment Pre- and Post-Kidney Transplantation
JR Zitzner, AR Tambur |
Cells | 2012 |
|
Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs
P Riquelme, EK Geissler, JA Hutchinson |
Transplantation Research | 2012 |
|
Peripheral regulatory cells immunophenotyping in kidney transplant recipients with different clinical profiles: a cross-sectional study
J Furuzawa-Carballeda, G Lima, P Simancas, D Ramos-Bello, M Simancas, IC Bostock, M Vilatobá, B Gabilondo, J Granados, L Morales-Buenrostro, J Alberú, L Llorente |
Journal of Transplantation | 2012 |
|
Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant
R Danger, A Pallier, M Giral, M Martínez-Llordella, JJ Lozano, N Degauque, A Sanchez-Fueyo, JP Soulillou, S Brouard |
Journal of the American Society of Nephrology : JASN | 2012 |
|
Bidirectional alloreactivity
WJ Burlingham, G Benichou |
Chimerism | 2012 |
|
Intra-Graft Molecular Pathways Predict the Development of Operational Tolerance in Human Liver Transplantation
Felix Bohne, Marc Martínez-Llordella, Juan Lozano, Rosa Miquel, Carlos Benitez, Maria-Carlotta Londoño, Tommaso-María Manzia, Roberta Angelico, Dorine W. Swinkels, Harold Tjalsma, Marta Lopez, Juan G. Abraldes, Eliano Bonaccorsi-Riani, Elmar Jaeckel, Richard Taubert, Jacques Pirenne, Antoni Rimola, Giuseppe Tisone, Alberto Sanchez-Fueyo |
Journal of Clinical Investigation | 2011 |
|
Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation--a phase I study (MISOT-I)
FC Popp, B Fillenberg, E Eggenhofer, P Renner, J Dillmann, V Benseler, AA Schnitzbauer, J Hutchinson, R Deans, D Ladenheim, CA Graveen, F Zeman, M Koller, MJ Hoogduijn, EK Geissler, HJ Schlitt, MH Dahlke |
Journal of Translational Medicine | 2011 |
|
Challenges in the pursuit of immune tolerance
GT Nepom, EW st Clair, LA Turka |
Immunological Reviews | 2011 |
|
Immunologic Basis of Graft Rejection and Tolerance Following Transplantation of Liver or Other Solid Organs
A Sánchez–Fueyo, TB Strom |
Gastroenterology | 2011 |
|
Preclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism
T Kawai, AB Cosimi, DH Sachs |
Current Opinion in Organ Transplantation | 2011 |
|
Clinical transplantation tolerance
KA Newell |
Seminars in Immunopathology | 2011 |
|
Experimental models of B cell tolerance in transplantation
ML Cowan, R Sciammas, AS Chong |
Seminars in Immunology | 2011 |
|
Moving to tolerance: Clinical application of T regulatory cells
AN McMurchy, A Bushell, MK Levings, KJ Wood |
Seminars in Immunology | 2011 |
|
Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis
TL Spivey, L Uccellini, ML Ascierto, G Zoppoli, VD Giorgi, LG Delogu, AM Engle, JM Thomas, E Wang, FM Marincola, D Bedognetti |
Journal of Translational Medicine | 2011 |
|
Donor-Specific Indirect Pathway Analysis Reveals a B-Cell-Independent Signature Which Reflects Outcomes in Kidney Transplant Recipients
LD Haynes, E Jankowska-Gan, A Sheka, MR Keller, MP Hernandez-Fuentes, RI Lechler, V Seyfert-Margolis, LA Turka, KA Newell, WJ Burlingham |
American Journal of Transplantation | 2011 |
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Biomarkers in solid organ transplantation: establishing personalized transplantation medicine
S Roedder, M Vitalone, P Khatri, MM Sarwal |
Genome Medicine | 2011 |
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Biomarkers of tolerance: searching for the hidden phenotype
E Perucha, I Rebollo-Mesa, P Sagoo, MP Hernandez-Fuentes |
Kidney International Supplements | 2011 |
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A Common Biomarker Signature for Tolerated Allografts and Self Tissues
AL Moine, ND Jones |
Frontiers in immunology | 2011 |
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Matchmaking the B-cell signature of tolerance to regulatory B cells
AS Chong, R Sciammas |
American Journal of Transplantation | 2011 |
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Identifying biomarkers as diagnostic tools in kidney transplantation
VR Mas, TF Mueller, KJ Archer, DG Maluf |
Expert Review of Molecular Diagnostics | 2011 |
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Histological findings in two renal transplants accomplishing operational tolerance criteria
MA Azancot, F Moreso, C Cantarell, IB Torres, DR Seron |
NDT Plus | 2011 |
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The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response
M Racapé, JP van Huyen, R Danger, M Giral, F Bleicher, Y Foucher, A Pallier, P Pilet, P Tafelmeyer, J Ashton-Chess, E Dugast, S Pettré, B Charreau, JP Soulillou, S Brouard |
PloS one | 2011 |
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Essential role for B cells in transplantation tolerance
RR Redfield, E Rodriguez, R Parsons, K Vivek, MM Mustafa, H Noorchashm, A Naji |
Current Opinion in Immunology | 2011 |
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MICROCHIMERISM IN PROMOTING GRAFT ACCEPTANCE IN CLINICAL TRANPLANTATION1
JM Mathew, JR Leventhal, J Miller |
Current Opinion in Organ Transplantation | 2011 |
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Grand Challenges in Alloimmunity and Transplantation
A Toubert |
Frontiers in immunology | 2011 |
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"Tip-toeing” to an assay for transplantation tolerance?
ML Alegre, AS Chong |
American Journal of Transplantation | 2011 |
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Tolerant Renal Transplant Recipients: Evidence for a B-Cell Signature Associated with Tolerance in Humans
Kenneth Newell, Adam Asare, Allan D. Kirk, Trang Gisler, Katarzyna Bourcier, Manikkam Suthanthiran, William Burlingham, William Marks, Iñaki Sanz, Robert Lechler, Maria Hernandez-Fuentes, Laurence A. Turka, Vicki Seyfert-Margolis |
Journal of Clinical Investigation | 2010 |
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Gazing into a crystal ball to predict kidney transplant outcome
Peter S. Heeger, Bernd Schroppel |
Journal of Clinical Investigation | 2010 |
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Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy
R Bacchetta, S Gregori, G Serafini, C Sartirana, U Schulz, E Zino, S Tomiuk, U Jansen, M Ponzoni, CT Paties, K Fleischhauer, MG Roncarolo |
Haematologica | 2010 |
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A 'biomarker signature' for tolerance in transplantation
MP Hernandez-Fuentes, RI Lechler |
Nature Reviews Nephrology | 2010 |
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The Immune Tolerance Network at 10 years: tolerance research at the bedside
JA Bluestone, H Auchincloss, GT Nepom, D Rotrosen, EW st. Clair, LA Turka |
Nature Reviews Immunology | 2010 |
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B cells and transplantation tolerance
AD Kirk, NA Turgeon, NN Iwakoshi |
Nature Reviews Nephrology | 2010 |
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Novel diagnostics in renal transplantation
NE Kieran, K Muczynski, V Gadi |
Chimerism | 2010 |
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