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Citations to this article

Role for α3 integrin in EMT and pulmonary fibrosis
Zea Borok
Zea Borok
Published December 22, 2008
Citation Information: J Clin Invest. 2009;119(1):7-10. https://doi.org/10.1172/JCI38084.
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Commentary

Role for α3 integrin in EMT and pulmonary fibrosis

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Abstract

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive (myo)fibroblast accumulation and collagen deposition. One possible source of (myo)fibroblasts is epithelial cells that undergo epithelial-mesenchymal transition (EMT), a process frequently mediated by TGF-β. In this issue of the JCI, Kim et al. report that epithelial cell–specific deletion of α3 integrin prevents EMT in mice, thereby protecting against bleomycin-induced fibrosis (see the related article beginning on page 213). The authors propose a novel mechanism linking TGF-β and β-catenin signaling in EMT through integrin-dependent association of tyrosine-phosphorylated β-catenin and pSmad2 and suggest targeted disruption of this interaction as a potential therapeutic approach.

Authors

Zea Borok

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Total
Citations: 4 1 2 2 2 1 2 2 2 1 1 5 1 1 27
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (27)

Title and authors Publication Year
The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression
Kanno Y
International journal of molecular sciences 2023
The Emerging Role of Cell Adhesion Molecules on Benign Prostatic Hyperplasia
Liu J, Zhang J, Fu X, Yang S, Li Y, Liu J, DiSanto ME, Chen P, Zhang X
International journal of molecular sciences 2023
What role does PDL1 play in EMT changes in tumors and fibrosis?
Zhang YC, Zhang YT, Wang Y, Zhao Y, He LJ
Frontiers in immunology 2023
A roadmap for developing and engineering in vitro pulmonary fibrosis models
Dabaghi M, Carpio MB, Saraei N, Moran-Mirabal JM, Kolb MR, Hirota JA
2023
Mannan-Binding Lectin Reduces Epithelial-Mesenchymal Transition in Pulmonary Fibrosis via Inactivating the Store-Operated Calcium Entry Machinery
Liu Y, Xie X, Wang P, Luo J, Chen Y, Xu Q, Zhou J, Lu X, Zhao J, Chen Z, Zuo D
Journal of Innate Immunity 2022
Cooperative signaling between integrins and growth factor receptors in fibrosis
H Maldonado, JS Hagood
Journal of Molecular Medicine 2021
TGF‑β inhibitor RepSox suppresses osteosarcoma via the JNK/Smad3 signaling pathway
D He, J Gao, L Zheng, S Liu, L Ye, H Lai, B Pan, W Pan, C Lou, Z Chen, S Fan
International journal of oncology 2021
MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review
SR Volovat, C Volovat, I Hordila, DA Hordila, CC Mirestean, OT Miron, C Lungulescu, DV Scripcariu, CR Stolniceanu, AA Konsoulova-Kirova, C Grigorescu, C Stefanescu, CC Volovat, I Augustin
Frontiers in Oncology 2020
The Scientific Foundation of Chinese Herbal Medicine against COVID-19
EL Leung, HD Pan, YF Huang, XX Fan, WY Wang, F He, J Cai, H Zhou, L Liu
Engineering 2020
Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?
RK Albert, B Smith, CE Perlman, DA Schwartz
American journal of respiratory and critical care medicine 2019
SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR)
Y Sun, B Lei, Q Huang
Medical science monitor : international medical journal of experimental and clinical research 2019
Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β
Y Tsubakihara, A Moustakas
International journal of molecular sciences 2018
BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis
E Cherubini, S Mariotta, D Scozzi, R Mancini, G Osman, M DAscanio, P Bruno, G Cardillo, A Ricci
Journal of Translational Medicine 2017
Electric field exposure promotes epithelial‑mesenchymal transition in human lens epithelial cells via integrin β1‑FAK signaling
J Liu, XL Yan, XL Zheng, L Mei, S Wang, J Han, H Yan
Molecular medicine reports 2017
Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition
A Moustakas, CH Heldin
Journal of Clinical Medicine 2016
Bone Morphogenetic Protein-7 Antagonizes Myocardial Fibrosis Induced by Atrial Fibrillation by Restraining Transforming Growth Factor-β (TGF-β)/Smads Signaling
Chen X, Xu J, Jiang B, Liu D
Medical science monitor : international medical journal of experimental and clinical research 2016
Pleural mesothelial cells in pleural and lung diseases
Hitesh Batra, Veena B. Antony
Journal of Thoracic Disease 2015
miRNAs and Other Epigenetic Changes as Biomarkers in Triple Negative Breast Cancer
A Mathe, R Scott, K Avery-Kiejda
International journal of molecular sciences 2015
Deficient repair response of IPF fibroblasts in a co-culture model of epithelial injury and repair
S Prasad, CM Hogaboam, G Jarai
Fibrogenesis & Tissue Repair 2014
Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis
S Karki, R Surolia, TD Hock, P Guroji, JS Zolak, R Duggal, T Ye, VJ Thannickal, VB Antony
The FASEB Journal 2013
Molecular and cellular mechanisms of pulmonary fibrosis
NW Todd, IG Luzina, SP Atamas
Fibrogenesis & Tissue Repair 2012
Inhalation treatment of pulmonary fibrosis by liposomal prostaglandin E2
V Ivanova, OB Garbuzenko, KR Reuhl, DC Reimer, VP Pozharov, T Minko
European Journal of Pharmaceutics and Biopharmaceutics 2012
Integrin α9β1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition
SK Gupta, S Oommen, MC Aubry, BP Williams, NE Vlahakis
Oncogene 2012
EMT and interstitial lung disease: a mysterious relationship
H Kage, Z Borok
Current Opinion in Pulmonary Medicine 2012
Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?
L Goitre, B Pergolizzi, E Ferro, L Trabalzini, SF Retta
Journal of Signal Transduction 2012
Identification of a Novel Inhibitor of the Canonical Wnt Pathway▿
K Park, K Lee, B Zhang, T Zhou, X He, G Gao, AR Murray, JX Ma
Molecular and cellular biology 2011
Microtopographical cues in 3D attenuate fibrotic phenotype and extracellular matrix deposition: implications for tissue regeneration
P Ayala, JI Lopez, TA Desai
Tissue Engineering Part A 2010

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