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L. Darryl Quarles
Published December 1, 2008
Citation Information: J Clin Invest. 2008;118(12):3820-3828. https://doi.org/10.1172/JCI36479.
Citation Information: J Clin Invest. 2008;118(12):3820-3828. https://doi.org/10.1172/JCI36479.
Abstract
Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and other organs to adjust phosphate balance and bone mineralization in response to changing physiological requirements. This review examines the newly discovered signaling pathways involved in the endocrine functions of bone, such as those mediated by the phosphaturic and 1,25(OH)2D-regulating hormone FGF23, and the broader systemic effects associated with abnormalities of calcium and phosphate homeostasis.
Authors
L. Darryl Quarles
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Citations to this article (172)
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Nature Reviews Rheumatology | 2012 |
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1,25-dihydroxyvitamin D(3) regulation of fibroblast growth factor-23 expression in bone cells: evidence for primary and secondary mechanisms modulated by leptin and interleukin-6
RK Saini, I Kaneko, PW Jurutka, R Forster, A Hsieh, JC Hsieh, MR Haussler, GK Whitfield |
Calcified Tissue International | 2012 |
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The role of Klotho in energy metabolism
MS Razzaque |
Nature Reviews Endocrinology | 2012 |
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Can features of phosphate toxicity appear in normophosphatemia?
S Osuka, MS Razzaque |
Journal of Bone and Mineral Metabolism | 2012 |
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Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice
NC Mackenzie, D Zhu, EM Milne, R Hof, A Martin, LD Quarles, DL Quarles, JL Millán, C Farquharson, VE MacRae |
PloS one | 2012 |
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FGF23 and PTH--double agents at the heart of CKD
J Silver, M Rodriguez, E Slatopolsky |
Nephrology Dialysis Transplantation | 2012 |
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(1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers
OM Gutiérrez, KT Smith, A Barchi-Chung, NM Patel, T Isakova, M Wolf |
Clinical journal of the American Society of Nephrology : CJASN | 2012 |
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Overexpression of the DMP1 C-Terminal Fragment Stimulates FGF23 and Exacerbates the Hypophosphatemic Rickets Phenotype in Hyp Mice
A Martin, V David, H Li, B Dai, JQ Feng, LD Quarles |
Molecular Endocrinology | 2012 |
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Fibroblast Growth Factor 23 and Inflammation in CKD
JM Mendoza, T Isakova, AC Ricardo, H Xie, SD Navaneethan, AH Anderson, LA Bazzano, D Xie, M Kretzler, L Nessel, LL Hamm, L Negrea, MB Leonard, D Raj, M Wolf |
Clinical journal of the American Society of Nephrology : CJASN | 2012 |
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Hypophosphatemic rickets
VS Jagtap, V Sarathi, AR Lila, T Bandgar, P Menon, NS Shah |
Indian journal of endocrinology and metabolism | 2012 |
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Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands
C Li, X Xie, X Wang, Y Sun, P Liu, L Chen, C Qin |
Journal Of Molecular Histology | 2012 |
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Physical function mitigates the adverse effects of being thin on mortality in a free-living older Taiwanese cohort.
Lee MS, Chen RC, Chang YH, Huang YC, Wahlqvist ML |
The journal of nutrition, health & aging | 2012 |
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Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone
EJ Weinman, D Steplock, S Shenolikar, R Biswas |
The Journal of biological chemistry | 2011 |
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Diseases of the parathyroid gland in chronic kidney disease
H Komaba, T Kakuta, M Fukagawa |
Clinical and Experimental Nephrology | 2011 |
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Vitamin D metabolism and innate immunity
V Lagishetty, NQ Liu, M Hewison |
Molecular and Cellular Endocrinology | 2011 |
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The bone and beyond: 'Dem bones' are made for more than walking
LD Quarles |
Nature Medicine | 2011 |
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Phosphate Sensing
C Bergwitz, H Jüppner |
Advances in Chronic Kidney Disease | 2011 |
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Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23–Klotho System
CY Cheng, M Kuro-o, MS Razzaque |
Advances in Chronic Kidney Disease | 2011 |
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Klotho and the aging process
M Kuro-o |
The Korean Journal of Internal Medicine | 2011 |
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Phosphate Metabolism in Cardiorenal Metabolic Disease
D Gupta, S Brietzke, MR Hayden, LR Kurukulasuriya, JR Sowers |
Cardiorenal Medicine | 2011 |
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Role of Klotho in Aging, Phosphate Metabolism, and CKD
GB John, CY Cheng, M Kuro-o |
American journal of kidney diseases : the official journal of the National Kidney Foundation | 2011 |
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Mineral and bone disorders in chronic kidney disease and end-stage renal disease patients: new insights into vitamin D receptor activation
J Bover, M Cozzolino |
Kidney International Supplements | 2011 |
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Oncogenic osteomalacia, raised FGF-23, and renal Fanconi syndrome
AG Norden, RJ Laing, P Rowe, RJ Unwin, O Wrong, AJ Crisp |
QJM | 2011 |
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Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
A Martin, S Liu, V David, H Li, A Karydis, JQ Feng, LD Quarles |
The FASEB Journal | 2011 |
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Chronic Kidney Disease Progression and Outcome According to Serum Phosphorus in Mild-to-Moderate Kidney Dysfunction
A Bellasi, M Mandreoli, L Baldrati, M Corradini, PD Nicolò, G Malmusi, A Santoro |
Clinical journal of the American Society of Nephrology : CJASN | 2011 |
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Hdac-mediated control of endochondral and intramembranous ossification.
Bradley EW, McGee-Lawrence ME, Westendorf JJ |
Critical reviews in eukaryotic gene expression | 2011 |
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Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23
C Bergwitz, H Jüppner |
Annual Review of Medicine | 2010 |
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Recent advances in renal phosphate handling
EG Farrow, KE White |
Nature Reviews Nephrology | 2010 |
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Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease
K Nitta |
International Journal of Nephrology | 2010 |
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FGF-23: More than a regulator of renal phosphate handling?
H Jüppner, M Wolf, IB Salusky |
Journal of Bone and Mineral Research | 2010 |
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Clinical practice: Fibroblast growth factor (FGF)23: a new hormone
US Alon |
European Journal of Pediatrics | 2010 |
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The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging
MR Haussler, CA Haussler, GK Whitfield, JC Hsieh, PD Thompson, TK Barthel, L Bartik, JB Egan, Y Wu, JL Kubicek, CL Lowmiller, EW Moffet, RE Forster, PW Jurutka |
The Journal of Steroid Biochemistry and Molecular Biology | 2010 |
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Disorders of phosphorus homeostasis
R Lee, TJ Weber |
Current opinion in endocrinology, diabetes, and obesity | 2010 |
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A potential link between phosphate and aging—Lessons from Klotho-deficient mice
M Kuro-o |
Mechanisms of Ageing and Development | 2010 |
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Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
H Li, A Martin, V David, LD Quarles |
American journal of physiology. Endocrinology and metabolism | 2010 |
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Osteocyte: the unrecognized side of bone tissue
GY Rochefort, S Pallu, CL Benhamou |
Osteoporosis International | 2010 |
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FGF23 and the parathyroid glands
J Silver, T Naveh-Many |
Pediatric Nephrology | 2010 |
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ASARM mineralization hypothesis: a bridge too far?
V David, LD Quarles |
Journal of Bone and Mineral Research | 2010 |
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Vitamin D, disease and therapeutic opportunities
LA Plum, HF DeLuca |
Nature Reviews Drug Discovery | 2010 |
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Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets
B Lorenz-Depiereux, D Schnabel, D Tiosano, G Häusler, TM Strom |
The American Journal of Human Genetics | 2010 |
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Update in vitamin D
JS Adams, M Hewison |
The Journal of clinical endocrinology and metabolism | 2010 |
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Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial
V Fedirko, RM Bostick, Q Long, WD Flanders, ML McCullough, E Sidelnikov, CR Daniel, RE Rutherford, A Shaukat |
Cancer epidemiology, biomarkers & prevention | 2010 |
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Alteration of vitamin D metabolic enzyme expression and calcium transporter abundance in kidney involved in type 1 diabetes-induced bone loss
Y Zhang, CJ Papasian, HW Deng |
Osteoporosis International | 2010 |
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Reduced Hepatic Synthesis of Calcidiol in Uremia
J Michaud, J Naud, D Ouimet, C Demers, JL Petit, FA Leblond, A Bonnardeaux, M Gascon-Barré, V Pichette |
Journal of the American Society of Nephrology : JASN | 2010 |
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Mutation analysis and serum FGF23 level in a patient with pulmonary alveolar microlithiasis.
Olauson H, Brandenburg V, Larsson TE |
Endocrine | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis
MS Razzaque |
Nature Reviews Endocrinology | 2009 |
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Hypophosphatemia: the common denominator of all rickets
D Tiosano, Z Hochberg |
Journal of Bone and Mineral Metabolism | 2009 |
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Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone
S Liu, W Tang, J Fang, J Ren, H Li, Z Xiao, LD Quarles |
Molecular Endocrinology | 2009 |
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Overview of the FGF23-Klotho axis
M Kuro-o |
Pediatric Nephrology | 2009 |
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Klotho
M Kuro-o |
Pflügers Archiv - European Journal of Physiology | 2009 |
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Familial Tumoral Calcinosis: From Characterization of a Rare Phenotype to the Pathogenesis of Ectopic Calcification
E Sprecher |
Journal of Investigative Dermatology | 2009 |
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Do osteocytes contribute to phosphate homeostasis?
JQ Feng, L Ye, S Schiavi |
Current Opinion in Nephrology and Hypertension | 2009 |
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Vitamin D, calcium, and colorectal neoplasia: new insights on mechanisms of action
ET Jacobs, PW Jurutka, ME Martínez, DS Alberts |
Cancer prevention research (Philadelphia, Pa.) | 2009 |
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Fibroblast growth factor-23 is associated with C-reactive protein, serum phosphate and bone mineral density in chronic kidney disease
P Manghat, WD Fraser, AS Wierzbicki, I Fogelman, DJ Goldsmith, G Hampson |
Osteoporosis International | 2009 |
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