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Citations to this article

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
Vanessa Brochard, … , Etienne C. Hirsch, Stéphane Hunot
Vanessa Brochard, … , Etienne C. Hirsch, Stéphane Hunot
Published December 22, 2008
Citation Information: J Clin Invest. 2009;119(1):182-192. https://doi.org/10.1172/JCI36470.
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Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

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Abstract

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the adaptive immune system in PD remains enigmatic. Here we showed that CD8+ and CD4+ T cells but not B cells had invaded the brain in both postmortem human PD specimens and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD during the course of neuronal degeneration. We further demonstrated that MPTP-induced dopaminergic cell death was markedly attenuated in the absence of mature T lymphocytes in 2 different immunodeficient mouse strains (Rag1–/– and Tcrb–/– mice). Importantly, similar attenuation of MPTP-induced dopaminergic cell death was seen in mice lacking CD4 as well as in Rag1–/– mice reconstituted with FasL-deficient splenocytes. However, mice lacking CD8 and Rag1–/– mice reconstituted with IFN-γ–deficient splenocytes were not protected. These data indicate that T cell–mediated dopaminergic toxicity is almost exclusively arbitrated by CD4+ T cells and requires the expression of FasL but not IFNγ. Further, our data may provide a rationale for targeting the adaptive arm of the immune system as a therapeutic strategy in PD.

Authors

Vanessa Brochard, Béhazine Combadière, Annick Prigent, Yasmina Laouar, Aline Perrin, Virginie Beray-Berthat, Olivia Bonduelle, Daniel Alvarez-Fischer, Jacques Callebert, Jean-Marie Launay, Charles Duyckaerts, Richard A. Flavell, Etienne C. Hirsch, Stéphane Hunot

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
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Communications biology 2023
Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease
Grotemeyer A, Fischer JF, Koprich JB, Brotchie JM, Blum R, Volkmann J, Ip CW
Journal of Neuroinflammation 2023
Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases.
Poppell M, Hammel G, Ren Y
International journal of molecular sciences 2023
Pathological mechanisms of neuroimmune response and multitarget disease-modifying therapies of mesenchymal stem cells in Parkinson’s disease
Zhuo Y, Li X, He Z, Lu M
Stem Cell Research & Therapy 2023
Microglia Mediated Neuroinflammation in Parkinson’s Disease
Isik S, Yeman Kiyak B, Akbayir R, Seyhali R, Arpaci T
Cells 2023
C1q and central nervous system disorders
Zhang W, Chen Y, Pei H
Frontiers in immunology 2023
FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction.
Ying K, Chen J, Fu Z, Ren B
Journal of molecular neuroscience : MN 2023
Redox Imbalance in Neurological Disorders in Adults and Children
Rey F, Berardo C, Maghraby E, Mauri A, Messa L, Esposito L, Casili G, Ottolenghi S, Bonaventura E, Cuzzocrea S, Zuccotti G, Tonduti D, Esposito E, Paterniti I, Cereda C, Carelli S
Antioxidants 2023
Revisiting Alpha-Synuclein Pathways to Inflammation
Lyra P, Machado V, Rota S, Chaudhuri KR, Botelho J, Mendes JJ
International journal of molecular sciences 2023
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.
Piwecka M, Rajewsky N, Rybak-Wolf A
Nature reviews. Neurology 2023
Pro-Inflammatory Priming of the Brain: The Underlying Cause of Parkinson’s Disease
Martins AC, Lima IS, Pêgo AC, Sá Pereira I, Martins G, Kapitão A, Gozzelino R
International journal of molecular sciences 2023
The contribution of the peripheral immune system to neurodegeneration.
Berriat F, Lobsiger CS, Boillée S
Nature Neuroscience 2023
Association between peripheral adaptive immune markers and disease progression in Parkinson's disease
Xiao Y, Wei Q, Ou R, Yang T, Jiang Q, Hou Y, Zhang L, Liu K, Wang S, Lin J, Zhao B, Song W, Chen X, Wu Y, Li C, Shang H
Journal of Neurology 2023
Ovalbumin-specific CD4+ and CD8+ T cells contribute to different susceptibility for Theiler’s murine encephalomyelitis virus persistence
Wannemacher R, Reiß A, Rohn K, Lühder F, Flügel A, Baumgärtner W, Hülskötter K
Frontiers in immunology 2023
The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease
de Rus Jacquet A, Alpaugh M, Denis HL, Tancredi JL, Boutin M, Decaestecker J, Beauparlant C, Herrmann L, Saint-Pierre M, Parent M, Droit A, Breton S, Cicchetti F
Nature Communications 2023
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease.
Schonhoff AM, Figge DA, Williams GP, Jurkuvenaite A, Gallups NJ, Childers GM, Webster JM, Standaert DG, Goldman JE, Harms AS
Nature Communications 2023
CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson's disease.
Frosch M, Amann L, Prinz M
Nature Communications 2023
GATA3 as a Blood-Based RNA Biomarker for Idiopathic Parkinson’s Disease
Acharya S, Lumley AI, Zhang L, Vausort M, Devaux Y
International journal of molecular sciences 2023
Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson’s disease
Srivastava P, Nishiyama S, Lin SH, Srivastava A, Su C, Peng W, Levy M, Schwarzschild M, Xu Y, Chen X
Research square 2023
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate Parkinson’s disease and neuronal damage through inhibition of microglia
Zhang ZX, Zhou YJ, Gu P, Zhao W, Chen HX, Wu RY, Zhou LY, Cui QZ, Sun SK, Zhang LQ, Zhang K, Xu HJ, Chai XQ, An SJ
Neural Regeneration Research 2023
Deep brain stimulation improves central nervous system inflammation in Parkinson's disease: Evidence and perspectives.
Chang L, Dong WW, Luo B, Qiu C, Lu Y, Lin XJ, Zhang WB
CNS Neuroscience & Therapeutics 2023
Alterations of Plasmatic Biomarkers of Neurodegeneration in Mucopolysaccharidosis Type II Patients Under Enzyme Replacement Therapy.
Jacques CED, Guerreiro G, Lopes FF, de Souza CFM, Giugliani R, Vargas CR
Cell Biochemistry and Biophysics 2023
Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats
Lamberty BG, Estrella LD, Mattingly JE, Emanuel K, Trease A, Totusek S, Sheldon L, George JW, Almikhlafi MA, Farmer T, Stauch KL
2023
Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics
Iyaswamy A, Lu K, Guan XJ, Kan Y, Su C, Liu J, Jaganathan R, Vasudevan K, Paul J, Thakur A, Li M
Biomedicines 2023
Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases
Abbaoui A, Fatoba O, Yamashita T
Frontiers in cellular neuroscience 2023
Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain.
Hobson BD, Stanley AT, De Los Santos MB, Culbertson B, Mosharov EV, Sims PA, Sulzer D
Brain, Behavior, and Immunity 2023
The Molecular Mechanisms of the Relationship between Insulin Resistance and Parkinson's Disease Pathogenesis.
Ruiz-Pozo VA, Tamayo-Trujillo R, Cadena-Ullauri S, Frias-Toral E, Guevara-Ramírez P, Paz-Cruz E, Chapela S, Montalván M, Morales-López T, Simancas-Racines D, Zambrano AK
Nutrients 2023
Glycolipids in Parkinson's disease: beyond neuronal function.
Spanos F, Deleidi M
FEBS Open Bio 2023
T Lymphocytes and Their Potential Role in Dementia with Lewy Bodies
Amin J, Gee C, Stowell K, Coulthard D, Boche D
Cells 2023
Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?
Furgiuele A, Pereira FC, Martini S, Marino F, Cosentino M
IBMS BoneKEy 2023
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson’s Disease Progression in Mice
Park SY, Yang H, Kim S, Yang J, Go H, Bae H
International journal of molecular sciences 2023
Clinical biomarkers for Lewy body diseases
Abdelmoaty MM, Lu E, Kadry R, Foster EG, Bhattarai S, Mosley RL, Gendelman HE
Cell & Bioscience 2023
CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease
Zhao J, An K, Mao Z, Qu Y, Wang D, Li J, Min Z, Xue Z
Frontiers in aging neuroscience 2023
Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice
Bai XB, Xu S, Zhou LJ, Meng XQ, Li YL, Chen YL, Jiang YH, Lin WZ, Chen BY, Du LJ, Tian GC, Liu Y, Duan SZ, Zhu YQ
Microbiome 2023
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Bérard M, Martínez-Drudis L, Sheta R, El-Agnaf OM, Oueslati A
Molecular Neurodegeneration 2023
CD8+ T cells in brain injury and neurodegeneration
Zhang Z, Duan Z, Cui Y
Frontiers in cellular neuroscience 2023
Cytokine activity in Parkinson’s disease
Dzamko N
2023
Microglial Inflammatory Responses to SARS-CoV-2 Infection: A Comprehensive Review.
Dey R, Bishayi B
Cellular and Molecular Neurobiology 2023
Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson’s Disease
Saramowicz K, Siwecka N, Galita G, Kucharska-Lusina A, Rozpędek-Kamińska W, Majsterek I
International journal of molecular sciences 2023
Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease
Srivastava P, Nishiyama S, Zhou F, Lin SH, Srivastava A, Su C, Xu Y, Peng W, Levy M, Schwarzschild M, Chen X
Journal of Neuroimmune Pharmacology 2023
Detecting ferroptosis and immune infiltration profiles in multiple system atrophy using postmortem brain tissue
Chen L, Mao L, Lu H, Liu P
Frontiers in neuroscience 2023
Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.
Chang H, Chen E, Hu Y, Wu L, Deng L, Ye-Lehmann S, Mao X, Zhu T, Liu J, Chen C
2023
Novel therapeutic approaches to target neurodegeneration
de la Fuente AG, Pelucchi S, Mertens J, Di Luca M, Mauceri D, Marcello E
British Journal of Pharmacology 2023
Interaction of an α-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
Garretti F, Monahan C, Sloan N, Bergen J, Shahriar S, Kim SW, Sette A, Cutforth T, Kanter E, Agalliu D, Sulzer D
Neuron 2023
Brain and Systemic Inflammation in De Novo Parkinson's Disease
Yacoubian TA, Fang YD, Gerstenecker A, Amara A, Stover N, Ruffrage L, Collette C, Kennedy R, Zhang Y, Hong H, Qin H, McConathy J, Benveniste EN, Standaert DG
Movement Disorders 2023
Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease
E Kozina, M Byrne, R Smeyne
npj Parkinson's Disease 2022
Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
C Rickenbach, C Gericke
Frontiers in neuroscience 2022
The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases
X Zang, S Chen, J Zhu, J Ma, Y Zhai
Frontiers in aging neuroscience 2022
Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit
G Paul, O Elabi
Frontiers in aging neuroscience 2022
Emerging targets signaling for inflammation in Parkinson’s disease drug discovery
R Khairnar, N Parihar, K Prabhavalkar, L Bhatt
Metabolic Brain Disease 2022
Noninvasive Imaging of CD4+ T Cells in Humanized Mice
V Nagle, C Hertz, K Henry, M Graham, C Campos, N Pillarsetty, A Schietinger, I Mellinghoff, J Lewis
Molecular cancer therapeutics 2022
Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
T Lai, Y Kim, H Ma, Y Kim
Journal of Movement Disorders 2022
Specific immune status in Parkinson's disease at different ages of onset.
Tian J, Dai SB, Jiang SS, Yang WY, Yan YQ, Lin ZH, Dong JX, Liu Y, Zheng R, Chen Y, Zhang BR, Pu JL
npj Parkinson's Disease 2022
Peripheral Immune Cell Numbers and C-Reactive Protein in Parkinson's Disease: Results from a Population-Based Study.
Dommershuijsen LJ, Ruiter R, Erler NS, Rizopoulos D, Ikram MA, Ikram MK
Journal of Parkinson's disease 2022
Inflammation and immune dysfunction in Parkinson disease.
Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V
Nature reviews. Immunology 2022
Global Characterization of Peripheral B Cells in Parkinson's Disease by Single-Cell RNA and BCR Sequencing.
Wang P, Luo M, Zhou W, Jin X, Xu Z, Yan S, Li Y, Xu C, Cheng R, Huang Y, Lin X, Yao L, Nie H, Jiang Q
Frontiers in immunology 2022
Changes of T lymphocyte subpopulations and their roles in predicting the risk of Parkinson's disease.
He Y, Peng K, Li R, Zhang Z, Pan L, Zhang T, Lin A, Hong R, Nie Z, Guan Q, Jin L
Journal of Neurology 2022
DAT and TH expression marks human Parkinson's disease in peripheral immune cells.
Gopinath A, Mackie P, Hashimi B, Buchanan AM, Smith AR, Bouchard R, Shaw G, Badov M, Saadatpour L, Gittis A, Ramirez-Zamora A, Okun MS, Streit WJ, Hashemi P, Khoshbouei H
npj Parkinson's Disease 2022
The immunology of Parkinson's disease.
Zhu B, Yin D, Zhao H, Zhang L
Seminars in Immunopathology 2022
A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease.
Salemi M, Lanza G, Mogavero MP, Cosentino FII, Borgione E, Iorio R, Ventola GM, Marchese G, Salluzzo MG, Ravo M, Ferri R
International journal of molecular sciences 2022
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells
Ng L, Wang X, Yang C, Su C, Li M, Cheung AK
Frontiers in immunology 2022
Peripheral inflammatory cytokines and motor symptoms in persons with Parkinson's disease
Diaz K, Kohut ML, Russell DW, Stegemöller EL
2022
The blood-brain barrier in aging and neurodegeneration
Knox EG, Aburto MR, Clarke G, Cryan JF, O\u2019Driscoll CM
Molecular Psychiatry 2022
Neuroinflammation in Parkinson’s Disease – Putative Pathomechanisms and Targets for Disease-Modification
Grotemeyer A, McFleder RL, Wu J, Wischhusen J, Ip CW
Frontiers in immunology 2022
Age-Related Midbrain Inflammation and Senescence in Parkinson’s Disease
Russo T, Riessland M
Frontiers in aging neuroscience 2022
Integrating Primary Astrocytes in a Microfluidic Model of the Blood-Brain Barrier.
Lauranzano E, Rasile M, Matteoli M
Methods in molecular biology (Clifton, N.J.) 2022
Prognostic significance of SNCA and its methylation in bladder cancer
Wu Z, Xia C, Zhang C, Yang D, Ma K
BMC Cancer 2022
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
Heidari A, Yazdanpanah N, Rezaei N
Journal of Neuroinflammation 2022
Challenges of repurposing tetracyclines for the treatment of Alzheimer's and Parkinson's disease.
Markulin I, Matasin M, Turk VE, Salković-Petrisic M
Journal of neural transmission (Vienna, Austria : 1996) 2022
Survival motor neuron protein deficiency alters microglia reactivity.
Khayrullina G, Alipio-Gloria ZA, Deguise MO, Gagnon S, Chehade L, Stinson M, Belous N, Bergman EM, Lischka FW, Rotty J, Dalgard CL, Kothary R, Johnson KA, Burnett BG
Glia 2022
α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease.
Liu Z, Chan RB, Cai Z, Liu X, Wu Y, Yu Z, Feng T, Yang Y, Zhang J
Journal of Neuroinflammation 2022
The aging immune system in Alzheimer's and Parkinson's diseases.
Heavener KS, Bradshaw EM
Seminars in Immunopathology 2022
Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson’s Disease Research and Therapeutic Development
McComish SF, MacMahon Copas AN, Caldwell MA
Frontiers in neuroscience 2022
The Pathological Mechanism Between the Intestine and Brain in the Early Stage of Parkinson's Disease
Yang R, Gao G, Yang H
Frontiers in aging neuroscience 2022
Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner
Liu W, Fan M, Lu W, Zhu W, Meng L, Lu S
Frontiers in immunology 2022
Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review
Fathi M, Vakili K, Yaghoobpoor S, Qadirifard MS, Kosari M, Naghsh N, Asgari taei A, Klegeris A, Dehghani M, Bahrami A, Taheri H, Mohamadkhani A, Hajibeygi R, Rezaei Tavirani M, Sayehmiri F
Frontiers in aging neuroscience 2022
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease.
Garcia P, Jürgens-Wemheuer W, Uriarte Huarte O, Michelucci A, Masuch A, Brioschi S, Weihofen A, Koncina E, Coowar D, Heurtaux T, Glaab E, Balling R, Sousa C, Kaoma T, Nicot N, Pfander T, Schulz-Schaeffer W, Allouche A, Fischer N, Biber K, Kleine-Borgmann F, Mittelbronn M, Ostaszewski M, Schmit KJ, Buttini M
Glia 2022
Monocyte biomarkers define sargramostim treatment outcomes for Parkinson's disease.
Abdelmoaty MM, Machhi J, Yeapuri P, Shahjin F, Kumar V, Olson KE, Mosley RL, Gendelman HE
Clinical and Translational Medicine 2022
Iron, Neuroinflammation and Neurodegeneration.
Ward RJ, Dexter DT, Crichton RR
International journal of molecular sciences 2022
Identification of Immune-Related Hub Genes in Parkinson's Disease.
Chen L, Wang Y, Huang J, Hu B, Huang W
Frontiers in Genetics 2022
Research progress in the early diagnosis of Parkinson's disease.
Xie L, Hu L
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2022
Neuronal Presentation of Antigen and Its Possible Role in Parkinson’s Disease
Hobson BD, Sulzer D
Journal of Parkinson's disease 2022
Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study
Liu SY, Qiao HW, Song TB, Liu XL, Yao YX, Zhao CS, Barret O, Xu SL, Cai YN, Tamagnan GD, Sossi V, Lu J, Chan P
Journal of Neuroinflammation 2022
Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases.
Boyd RJ, Avramopoulos D, Jantzie LL, McCallion AS
Journal of Neuroinflammation 2022
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.
Mysiris DS, Vavougios GD, Karamichali E, Papoutsopoulou S, Stavrou VT, Papayianni E, Boutlas S, Mavridis T, Foka P, Zarogiannis SG, Gourgoulianis K, Xiromerisiou G
International journal of molecular sciences 2022
T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV.
Williams DW, Flores BR, Xu Y, Wang Y, Yu D, Peters BA, Adedimeji A, Wilson TE, Merenstein D, Tien PC, Cohen MH, Weber KM, Adimora AA, Ofotokun I, Fischl M, Turan J, Turan B, Laumet G, Landay AL, Dastgheyb RM, Gange SJ, Weiser SD, Rubin LH
2022
The role of antiviral CD8+ T cells in cognitive impairment.
Reagin KL, Funk KE
Current Opinion in Neurobiology 2022
Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities
Araújo B, Caridade-Silva R, Soares-Guedes C, Martins-Macedo J, Gomes ED, Monteiro S, Teixeira FG
Cells 2022
Genotype–phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer’s disease
Dressman D, Buttrick T, Cimpean M, Bennett D, Menon V, Bradshaw EM, Vardarajan B, Elyaman W
Human Molecular Genetics 2022
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
DeMaio A, Mehrotra S, Sambamurti K, Husain S
Journal of Neuroinflammation 2022
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson’s disease
Guan Q, Liu W, Mu K, Hu Q, Xie J, Cheng L, Wang X
Frontiers in immunology 2022
Lymphocyte Count and Neutrophil-to-Lymphocyte Ratio Are Associated with Mild Cognitive Impairment in Parkinson’s Disease: A Single-Center Longitudinal Study
Contaldi E, Magistrelli L, Cosentino M, Marino F, Comi C
Journal of Clinical Medicine 2022
T Lymphocytes in Parkinson's Disease.
Contaldi E, Magistrelli L, Comi C
Journal of Parkinson's disease 2022
Age-Related Adaptive Immune Changes in Parkinson's Disease.
Kouli A, Williams-Gray CH
Journal of Parkinson's disease 2022
Inflammatory Animal Models of Parkinson's Disease.
García-Revilla J, Herrera AJ, de Pablos RM, Venero JL
Journal of Parkinson's disease 2022
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.
Terkelsen MH, Klaestrup IH, Hvingelby V, Lauritsen J, Pavese N, Romero-Ramos M
Journal of Parkinson's disease 2022
Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.
Williams GP, Schonhoff AM, Sette A, Lindestam Arlehamn CS
Journal of Parkinson's disease 2022
The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease.
Alosaimi F, Boonstra JT, Tan S, Temel Y, Jahanshahi A
Frontiers in neuroscience 2022
Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition
Princiotta Cariddi L, Mauri M, Cosentino M, Versino M, Marino F
International journal of molecular sciences 2022
Natural product-based pharmacological studies for neurological disorders
Puri V, Kanojia N, Sharma A, Huanbutta K, Dheer D, Sangnim T
Frontiers in pharmacology 2022
WDR43 is a potential diagnostic biomarker and therapeutic target for osteoarthritis complicated with Parkinson’s disease
Heng H, Liu J, Hu M, Li D, Su W, Li J
Frontiers in cellular neuroscience 2022
Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model
Chovar-Vera O, López E, Gálvez-Cancino F, Prado C, Franz D, Figueroa DA, Espinoza A, Figueroa C, Lladser A, Pacheco R
Cells 2022
Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation
Silva DF, Empadinhas N, Cardoso SM, Esteves AR
Antioxidants 2022
Calpain activation and progression of inflammatory cycles in Parkinson’s disease
Gao A, McCoy HM, Zaman V, Shields DC, Banik NL, Haque A
2022
How the immune system shapes neurodegenerative diseases.
Mason HD, McGavern DB
Trends in Neurosciences 2022
Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson's Disease.
Al-Nusaif M, Lin Y, Li T, Cheng C, Le W
International journal of molecular sciences 2022
Mechanisms of Autoimmune Cell in DA Neuron Apoptosis of Parkinson's Disease: Recent Advancement
Zheng Z, Zhang S, Zhang H, Gao Z, Wang X, Liu X, Xue C, Yao L, Lu G
Oxidative medicine and cellular longevity 2022
High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer’s and Parkinson’s disease
Emery DC, Davies M, Cerajewska TL, Taylor J, Hazell M, Paterson A, Allen-Birt SJ, West NX
Frontiers in aging neuroscience 2022
Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.
Badr M, McFleder RL, Wu J, Knorr S, Koprich JB, Hünig T, Brotchie JM, Volkmann J, Lutz MB, Ip CW
Journal of Neuroinflammation 2022
An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system
Komal P, Manjari SK, Nashmi R
2022
Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides
Levite M
Neural Regeneration Research 2022
Genome integrity and inflammation in the nervous system.
Aditi, McKinnon PJ
DNA repair 2022
Unaltered T cell responses to common antigens in individuals with Parkinson’s disease
Williams GP, Muskat K, Frazier A, Xu Y, Mateus J, Grifoni A, da Silva Antunes R, Weiskopf D, Amara AW, Standaert DG, Goldman JG, Litvan I, Alcalay RN, Sulzer D, Lindestam Arlehamn CS, Sette A
Journal of the Neurological Sciences 2022
Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease
Basurco L, Abellanas MA, Ayerra L, Conde E, Vinueza\u2010Gavilanes R, Luquin E, Vales A, Vilas A, Martin\u2010Uriz PS, Tamayo I, Alonso MM, Hernaez M, Gonzalez\u2010Aseguinolaza G, Clavero P, Mengual E, Arrasate M, Hervás\u2010Stubbs S, Aymerich MS
Glia 2022
Glia as antigen-presenting cells in the central nervous system
Sutter PA, Crocker SJ
Current Opinion in Neurobiology 2022
T cells, α-synuclein and Parkinson disease.
Garretti F, Monahan C, Sette A, Agalliu D, Sulzer D
Handbook of Clinical Neurology 2022
Neuroinflammation: 2022 update
Lassmann H
Free neuropathology 2022
Development of an extended half-life GM-CSF fusion protein for Parkinson’s disease
Yeapuri P, Olson KE, Lu Y, Abdelmoaty MM, Namminga KL, Markovic M, Machhi J, Mosley RL, Gendelman HE
Journal of Controlled Release 2022
The complex role of inflammation and gliotransmitters in Parkinson's disease.
Gopinath A, Mackie PM, Phan LT, Tansey MG, Khoshbouei H
Neurobiology of Disease 2022
Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment
Salim S, Ahmad F, Banu A, Mohammad F
Journal of Advanced Research 2022
Regulatory T Cell Therapeutics for Neuroinflammatory Disorders.
Harkins AL, Kopec AL, Keeler AM
Critical reviews in immunology 2022
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology
MC Houser, WM Caudle, J Chang, GT Kannarkat, Y Yang, SD Kelly, D Oliver, V Joers, KM Shannon, A Keshavarzian, MG Tansey
Acta Neuropathologica Communications 2021
Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease
Z Yan, W Yang, H Wei, MN Dean, DG Standaert, GR Cutter, EN Benveniste, H Qin
Neurology: Neuroimmunology & Neuroinflammation 2021
Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson’s disease patients
Z Karaaslan, ÖT Kahraman, E Şanlı, HA Ergen, C Ulusoy, B Bilgiç, V Yılmaz, E Tüzün, HA Hanağası, Cİ Küçükali
Scientific Reports 2021
Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy
KM Delgado-Minjares, D Martinez-Fong, IA Martínez-Dávila, C Bañuelos, ME Gutierrez-Castillo, VM Blanco-Alvarez, MC Cardenas-Aguayo, J Luna-Muñoz, M Pacheco-Herrero, LO Soto-Rojas
International journal of molecular sciences 2021
Cellular and molecular pathophysiology in the progression of Parkinson’s disease
V Zaman, DC Shields, R Shams, KP Drasites, D Matzelle, A Haque, NL Banik
Metabolic Brain Disease 2021
Emerging targets for the diagnosis of Parkinson’s disease: examination of systemic biomarkers
L Cheslow, AE Snook, SA Waldman
Biomarkers in Medicine 2021
The Positive Role and Mechanism of Herbal Medicine in Parkinson’s Disease
R Yin, J Xue, Y Tan, C Fang, C Hu, Q Yang, X Mei, D Qi, S Hrelia
Oxidative Medicine & Cellular Longevity 2021
Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease
A Drobny, PA Ngo, MF Neurath, F Zunke, R López-Posadas
Frontiers in Medicine 2021
Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration
M Dolatshahi, M Sabahi, MH Aarabi
Molecular Neurobiology 2021
Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System
DC Ivan, S Walthert, K Berve, J Steudler, G Locatelli
Frontiers in immunology 2021
Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk
AP Passaro, AL Lebos, Y Yao, SL Stice
Frontiers in immunology 2021
Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model
S Lee, YJ Suh, S Yang, DG Hong, A Ishigami, H Kim, JS Hur, SC Chang, J Lee
International journal of molecular sciences 2021
Bilirubin: A Promising Therapy for Parkinson’s Disease
S Jayanti, R Moretti, C Tiribelli, S Gazzin
International journal of molecular sciences 2021
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity
E Gregersen, C Betzer, WS Kim, G Kovacs, L Reimer, GM Halliday, S Thiel, PH Jensen
Journal of Neuroinflammation 2021
T lymphocyte senescence is attenuated in Parkinson’s disease
A Kouli, M Jensen, V Papastavrou, KM Scott, C Kolenda, C Parker, IH Solim, M Camacho, C Martin-Ruiz, CH Williams-Gray
Journal of Neuroinflammation 2021
Cholinergic Modulation of the Immune System in Neuroinflammatory Diseases
M Reale, E Costantini
Diseases 2021
The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease
K Badanjak, S Fixemer, S Smajić, A Skupin, A Grünewald
International journal of molecular sciences 2021
The Intersection of Parkinson’s Disease, Viral Infections, and COVID-19
B Rosen, A Kurtishi, GR Vazquez-Jimenez, SG Møller
Molecular Neurobiology 2021
Potential Effects of Leukotriene Receptor Antagonist Montelukast in Treatment of Neuroinflammation in Parkinson’s Disease
J Wallin, P Svenningsson
International journal of molecular sciences 2021
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
L Muzio, A Viotti, G Martino
Frontiers in neuroscience 2021
Neuroimmune multi-hit perspective of coronaviral infection
S Hayley, H Sun
Journal of Neuroinflammation 2021
The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?
AN Copas, SF McComish, JM Fletcher, MA Caldwell
Frontiers in neurology 2021
B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights
JJ Ahn, M Abu-Rub, RH Miller
Cells 2021
Content of Peripheral Blood T- and B-Cell Subpopulations in Transgenic A53T Mice of Different Age (A Model of Parkinson’s Disease)
GV Idova, EL Alperina, MM Gevorgyan, MA Tikhonova, SY Zhanaeva
Bulletin of Experimental Biology and Medicine 2021
Highlighting Immune System and Stress in Major Depressive Disorder, Parkinson’s, and Alzheimer’s Diseases, with a Connection with Serotonin
AS Correia, A Cardoso, N Vale
International journal of molecular sciences 2021
Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson’s disease
EJ Shin, JH Jeong, Y Hwang, N Sharma, DK Dang, BT Nguyen, SY Nah, CG Jang, G Bing, T Nabeshima, HC Kim
Archives of Pharmacal Research 2021
High Inflammatory Tendency Induced by Malignant Stimulation Through Imbalance of CD28 and CTLA-4/PD-1 Contributes to Dopamine Neuron Injury
L Dong, YM Zheng, XG Luo, ZY He
Journal of inflammation research 2021
Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction
A Mancini, V Ghiglieri, L Parnetti, P Calabresi, MD Filippo
Frontiers in immunology 2021
Periphery and brain, innate and adaptive immunity in Parkinson’s disease
AS Harms, SA Ferreira, M Romero-Ramos
Acta Neuropathologica 2021
Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?
LY Tan, XY Yeo, HG Bae, DP Lee, RC Ho, JE Kim, DG Jo, S Jung
Life Sciences 2021
Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease
AF Magnusen, SL Hatton, R Rani, MK Pandey
Frontiers in neurology 2021
Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
XL Wang, L Li
Frontiers in Cellular and Infection Microbiology 2021
Paracellular and Transcellular Leukocytes Diapedesis Are Divergent but Interconnected Evolutionary Events
ME Mickael, N Kubick, P Klimovich, PH Flournoy, I Bieńkowska, M Sacharczuk
Genes & development 2021
Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
R Su, T Zhou
Frontiers in aging neuroscience 2021
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
P Wang, L Yao, M Luo, W Zhou, X Jin, Z Xu, S Yan, Y Li, C Xu, R Cheng, Y Huang, X Lin, K Ma, H Cao, H Liu, G Xue, F Han, H Nie, Q Jiang
Cell Discovery 2021
The cell biology of Parkinson’s disease
N Panicker, P Ge, VL Dawson, TM Dawson
The Journal of Cell Biology 2021
Abnormal B-Cell and Tfh-Cell Profiles in Patients With Parkinson Disease: A Cross-sectional Study
R Li, TF Tropea, LR Baratta, L Zuroff, ME Diaz-Ortiz, B Zhang, K Shinoda, A Rezk, RN Alcalay, A Chen-Plotkin, A Bar-Or
Neurology: Neuroimmunology & Neuroinflammation 2021
Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
AD Thome, F Atassi, J Wang, A Faridar, W Zhao, JR Thonhoff, DR Beers, EC Lai, SH Appel
npj Parkinson's Disease 2021
Immune cell compartmentalization for brain surveillance and protection
T Croese, G Castellani, M Schwartz
Nature Immunology 2021
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
OC Kwon, JJ Song, Y Yang, SH Kim, JY Kim, MJ Seok, I Hwang, JW Yu, J Karmacharya, HJ Maeng, J Kim, E Jho, SY Ko, H Son, MY Chang, SH Lee
EMBO Molecular Medicine 2021
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
JB Grigg, A Shanmugavadivu, T Regen, CN Parkhurst, A Ahmed, AM Joseph, M Mazzucco, K Gronke, A Diefenbach, G Eberl, T Vartanian, A Waisman, GF Sonnenberg
Nature 2021
Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics
O Bulut, G Kilic, J Domínguez-Andrés
Clinical Reviews in Allergy & Immunology 2021
Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
SM Carlisle, H Qin, RC Hendrickson, JE Muwanguzi, EJ Lefkowitz, RE Kennedy, Z Yan, TA Yacoubian, EN Benveniste, AB West, AS Harms, DG Standaert
npj Parkinson's Disease 2021
Protective Effect of the α7 Nicotinic Receptor Agonist PNU-282987 on Dopaminergic Neurons Against 6-Hydroxydopamine, Regulating Anti-neuroinflammatory and the Immune Balance Pathways in Rat.
Jiang Y, Ma H, Wang X, Wang Z, Yang Y, Li L, Feng T
Frontiers in aging neuroscience 2021
T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.
George S, Tyson T, Rey NL, Sheridan R, Peelaerts W, Becker K, Schulz E, Meyerdirk L, Burmeister AR, von Linstow CU, Steiner JA, Galvis MLE, Ma J, Pospisilik JA, Labrie V, Brundin L, Brundin P
Journal of Parkinson's disease 2021
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease.
Williams GP, Schonhoff AM, Jurkuvenaite A, Gallups NJ, Standaert DG, Harms AS
Brain : a journal of neurology 2021
Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Safety in Idiopathic Parkinson's Disease.
Schiess M, Suescun J, Doursout MF, Adams C, Green C, Saltarrelli JG, Savitz S, Ellmore TM
Movement disorders : official journal of the Movement Disorder Society 2021
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson's Disease.
Lee S, Suh YJ, Lee Y, Yang S, Hong DG, Thirumalai D, Chang SC, Chung KW, Jung YS, Moon HR, Chung HY, Lee J
2021
Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background.
Vavilova JD, Boyko AA, Ponomareva NV, Fokin VF, Fedotova EY, Streltsova MA, Kust SA, Grechikhina MV, Bril EV, Zimnyakova OS, Kovalenko EI, Sapozhnikov AM
International journal of molecular sciences 2021
LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.
Van der Perren A, Cabezudo D, Gelders G, Peralta Ramos JM, Van den Haute C, Baekelandt V, Lobbestael E
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021
Parkinson’s Disease: Can Targeting Inflammation Be an Effective Neuroprotective Strategy?
Gundersen V
Frontiers in neuroscience 2021
T-cell dysregulation is associated with disease severity in Parkinson’s Disease
Bhatia D, Grozdanov V, Ruf WP, Kassubek J, Ludolph AC, Weishaupt JH, Danzer KM
Journal of Neuroinflammation 2021
The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations
del Pilar C, Lebrón-Galán R, Pérez-Martín E, Pérez-Revuelta L, Ávila-Zarza CA, Alonso JR, Clemente D, Weruaga E, Díaz D
Frontiers in cellular neuroscience 2021
CD4+ T cells contribute to neurodegeneration in Lewy body dementia
Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, Davis MM, Poston KL, Wyss-Coray T
Science (New York, N.Y.) 2021
Infection and Risk of Parkinson's Disease.
Smeyne RJ, Noyce AJ, Byrne M, Savica R, Marras C
Journal of Parkinson's disease 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
Li W, Luo Y, Xu H, Ma Q, Yao Q
2021
Evidence for Peripheral Immune Activation in Parkinson’s Disease
Chen X, Feng W, Ou R, Liu J, Yang J, Fu J, Cao B, Chen Y, Wei Q, Shang H
Frontiers in aging neuroscience 2021
Multi-omic insights into Parkinson’s Disease: from genetic associations to functional mechanisms
Schilder BM, Navarro E, Raj T
Neurobiology of Disease 2021
RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson's disease.
Craig DW, Hutchins E, Violich I, Alsop E, Gibbs JR, Levy S, Robison M, Prasad N, Foroud T, Crawford KL, Toga AW, Whitsett TG, Kim S, Casey B, Reimer A, Hutten SJ, Frasier M, Kern F, Fehlman T, Keller A, Cookson MR, Van Keuren-Jensen K
2021
A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus
HM Makinde, DR Winter, D Procissi, EV Mike, AD Stock, MJ Kando, GT Gadhvi, S Droho, CL Bloomfield, ST Dominguez, MG Mayr, JA Lavine, C Putterman, CM Cuda
Frontiers in immunology 2020
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease
SK Nissen, SA Ferreira, MC Nielsen, C Schulte, K Shrivastava, D Hennig, A Etzerodt, JH Graversen, D Berg, W Maetzler, A Panhelainen, HJ Møller, K Brockmann, M RomeroRamos
Movement disorders : official journal of the Movement Disorder Society 2020
Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?
K Mayne, JA White, CE McMurran, FJ Rivera, AG de la Fuente
Frontiers in aging neuroscience 2020
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy
A Heras-Garvin, V Refolo, M Reindl, GK Wenning, N Stefanova
Journal of Neuroinflammation 2020
Glia Crosstalk in Neuroinflammatory Diseases
A Bernaus, S Blanco, A Sevilla
Frontiers in cellular neuroscience 2020
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
E Pasciuto, OT Burton, CP Roca, V Lagou, WD Rajan, T Theys, R Mancuso, RY Tito, L Kouser, Z Callaerts-Vegh, AG de la Fuente, T Prezzemolo, LG Mascali, A Brajic, CE Whyte, L Yshii, A Martinez-Muriana, M Naughton, A Young, A Moudra, P Lemaitre, S Poovathingal, J Raes, BD Strooper, DC Fitzgerald, J Dooley, A Liston
Cell 2020
Glycosphingolipids and neuroinflammation in Parkinson’s disease
K Belarbi, E Cuvelier, MA Bonte, M Desplanque, B Gressier, D Devos, MC Chartier-Harlin
Molecular Neurodegeneration 2020
Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
N Reich, C Hölscher
Frontiers in neuroscience 2020
Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's Disease
Y Hu, K Zhang, T Zhang, J Wang, F Chen, W Qin, W Tong, Q Guan, Y He, C Gu, X Chen, UJ Kang, YE Sun, S Li, L Jin
Frontiers in neurology 2020
Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
S Chamani, V Bianconi, A Tasbandi, M Pirro, GE Barreto, T Jamialahmadi, A Sahebkar
Mediators of Inflammation 2020
Critical Neurotransmitters in the Neuroimmune Network
TW Hodo, MT de Aquino, A Shimamoto, A Shanker
Frontiers in immunology 2020
Lymphocyte-Activation Gene 3 (LAG3) Protein as a Possible Therapeutic Target for Parkinson’s Disease: Molecular Mechanisms Connecting Neuroinflammation to α-Synuclein Spreading Pathology
E Angelopoulou, YN Paudel, C Villa, MF Shaikh, C Piperi
Biology : open access journal 2020
Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models
K Simmnacher, J Lanfer, T Rizo, J Kaindl, B Winner
Frontiers in cellular neuroscience 2020
New Insights into Immune-Mediated Mechanisms in Parkinson’s Disease
JS Tan, YX Chao, O Rötzschke, EK Tan
International journal of molecular sciences 2020
Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease
C Marogianni, M Sokratous, E Dardiotis, GM Hadjigeorgiou, D Bogdanos, G Xiromerisiou
International journal of molecular sciences 2020
Reduction of Peripheral Blood iNKT and γδT Cells in Patients With Parkinson's Disease: An Observational Study
C Zhou, X Zhou, D He, Z Li, X Xie, Y Ren
Frontiers in immunology 2020
Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration
J He, G Zhu, G Wang, F Zhang
Oxidative medicine and cellular longevity 2020
Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale
N Ruffini, S Klingenberg, S Schweiger, S Gerber
Cells 2020
The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols
S Aryal, T Skinner, B Bridges, JT Weber
Molecules (Basel, Switzerland) 2020
TLR7/8 in the Pathogenesis of Parkinson’s Disease
M Campolo, A Filippone, C Biondo, G Mancuso, G Casili, M Lanza, S Cuzzocrea, E Esposito, I Paterniti
International journal of molecular sciences 2020
Translation Imaging in Parkinson’s Disease: Focus on Neuroinflammation
S Belloli, M Morari, V Murtaj, S Valtorta, RM Moresco, MC Gilardi
Frontiers in aging neuroscience 2020
T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease
GP Williams, DJ Marmion, AM Schonhoff, A Jurkuvenaite, WJ Won, DG Standaert, JH Kordower, AS Harms
Acta Neuropathologica 2020
Battling Neurodegenerative Diseases with Adeno-Associated Virus-Based Approaches
O Mijanović, A Branković, AV Borovjagin, DV Butnaru, EA Bezrukov, RB Sukhanov, A Shpichka, P Timashev, I Ulasov
Viruses 2020
Role of Peripheral Immune Cells-Mediated Inflammation on the Process of Neurodegenerative Diseases
Q Yang, G Wang, F Zhang
Frontiers in immunology 2020
Regulatory Roles of Bone in Neurodegenerative Diseases
Z Yu, Z Ling, L Lu, J Zhao, X Chen, P Xu, X Zou
Frontiers in aging neuroscience 2020
From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
A Heras-Garvin, N Stefanova
Frontiers in synaptic neuroscience 2020
The Effect of Endurance Training on Brain-Derived Neurotrophic Factor and Inflammatory Markers in Healthy People and Parkinson's Disease. A Narrative Review
P Małczyńska-Sims, M Chalimoniuk, A Sułek
Frontiers in physiology 2020
Neuroinflammation and protein pathology in Parkinson’s disease dementia
A Kouli, M Camacho, K Allinson, CH Williams-Gray
Acta Neuropathologica Communications 2020
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
M Pajares, AI Rojo, G Manda, L Boscá, A Cuadrado
Cells 2020

Human Adipose Tissue-Derived Mesenchymal Stem Cells in Parkinson’s Disease: Inhibition of T Helper 17 Cell Differentiation and Regulation of Immune Balance Towards a Regulatory T Cell Phenotype


Y Bi, X Lin, H Liang, D Yang, X Zhang, J Ke, J Xiao, Z Chen, W Chen, X Zhang, S Wang, CF Liu
Clinical Interventions in Aging 2020
CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation
D Chakravarty, F Saadi, S Kundu, A Bose, R Khan, K Dine, LC Kenyon, KS Shindler, JD Sarma, S Schultz-Cherry
Journal of virology 2020
Immune cell regulation of glia during CNS injury and disease
AD Greenhalgh, S David, FC Bennett
Nature Reviews Neuroscience 2020
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
J Machhi, BD Kevadiya, IK Muhammad, J Herskovitz, KE Olson, RL Mosley, HE Gendelman
Molecular Neurodegeneration 2020
Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice
KE Olson, KL Namminga, AD Schwab, MJ Thurston, Y Lu, A Woods, L Lei, W Shen, F Wang, SB Joseph, HE Gendelman, RL Mosley
Neurotherapeutics 2020
Using multi-organ culture systems to study Parkinson’s disease
O Reiner, T Sapir, A Parichha
Molecular Psychiatry 2020
Inflammation in Experimental Models of α ‐Synucleinopathies
AS Harms, JH Kordower, A Sette, CS Arlehamn, D Sulzer, RH Mach
Movement disorders : official journal of the Movement Disorder Society 2020
Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain.
Rostami J, Fotaki G, Sirois J, Mzezewa R, Bergström J, Essand M, Healy L, Erlandsson A
Journal of Neuroinflammation 2020
Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease.
Haque A, Samantaray S, Knaryan VH, Capone M, Hossain A, Matzelle D, Chandran R, Shields DC, Farrand AQ, Boger HA, Banik NL
Experimental Neurology 2020
Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model.
Qiao CM, Sun MF, Jia XB, Li Y, Zhang BP, Zhao LP, Shi Y, Zhou ZL, Zhu YL, Cui C, Shen YQ
Neurochemical Research 2020
Immunotherapy for Parkinson's disease.
Schwab AD, Thurston MJ, Machhi J, Olson KE, Namminga KL, Gendelman HE, Mosley RL
Neurobiology of Disease 2020
Parkinson disease and the immune system - associations, mechanisms and therapeutics.
Tan EK, Chao YX, West A, Chan LL, Poewe W, Jankovic J
Nature reviews. Neurology 2020
Investigating lymphocyte populations in patients with Parkinson's disease.
Dzamko N
Annals of translational medicine 2020
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.
Guo X, Pan Y, Xiong M, Sanapala S, Anastasaki C, Cobb O, Dahiya S, Gutmann DH
Nature Communications 2020
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.
Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E
Journal of Neuroinflammation 2020
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia.
Poh L, Fann DY, Wong P, Lim HM, Foo SL, Kang SW, Rajeev V, Selvaraji S, Iyer VR, Parathy N, Khan MB, Hess DC, Jo DG, Drummond GR, Sobey CG, Lai MKP, Chen CL, Lim LHK, Arumugam TV
Molecular Psychiatry 2020
Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism
Liang T, Qian ZM, Mu MD, Yung WH, Ke Y
iScience 2020
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease
Li W, Chen S, Luo Y, Xia Y, Ma Q, Yao Q, Wu J
Experimental and therapeutic medicine 2020
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells
Panagiotakopoulou V, Ivanyuk D, De Cicco S, Haq W, Arsić A, Yu C, Messelodi D, Oldrati M, Schöndorf DC, Perez MJ, Cassatella RP, Jakobi M, Schneiderhan-Marra N, Gasser T, Nikić-Spiegel I, Deleidi M
Nature Communications 2020
Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation
Jiang R, Gao J, Shen J, Zhu X, Wang H, Feng S, Huang C, Shen H, Liu H
Frontiers in aging neuroscience 2020
RAGE Silencing Ameliorates Neuroinflammation by Inhibition of p38-NF-κB Signaling Pathway in Mouse Model of Parkinson's Disease.
Wang X, Sun X, Niu M, Zhang X, Wang J, Zhou C, Xie A
Frontiers in neuroscience 2020
Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation.
Cabezudo D, Baekelandt V, Lobbestael E
Frontiers in neuroscience 2020
Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation.
Campos J, Pacheco R
Seminars in Immunopathology 2020
Idebenone Ameliorates Rotenone-Induced Parkinson's Disease in Rats Through Decreasing Lipid Peroxidation.
Avcı B, Günaydın C, Güvenç T, Yavuz CK, Kuruca N, Bilge SS
Neurochemical Research 2020
Elevated Percentage of CD3+ T-Cells and CD4+/CD8+ Ratios in Multiple System Atrophy Patients
Cao B, Chen X, Zhang L, Wei Q, Liu H, Feng W, Chen Y, Shang H
Frontiers in neurology 2020
Prefrontal cortex transcriptomic deconvolution implicates monocyte infiltration in Parkinson’s disease
Batchu S
Neurodegenerative Diseases 2020
Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation.
Ugalde V, Contreras F, Prado C, Chovar O, Espinoza A, Pacheco R
Mucosal Immunology 2020
T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease
Subbarayan MS, Hudson C, Moss LD, Nash KR, Bickford PC
Journal of Neuroinflammation 2020
Azathioprine immunosuppression and disease modification in Parkinson's disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol.
Greenland JC, Cutting E, Kadyan S, Bond S, Chhabra A, Williams-Gray CH
BMJ Open 2020
Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils
Roux A, Wang X, Becker K, Ma J
Journal of Parkinson's disease 2020
Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.
Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, Breen DP, Cummins G, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams-Gray CH
Brain, Behavior, and Immunity 2020
Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity
B Stutz, C Nasrallah, M Nigro, D Curry, ZW Liu, XB Gao, JD Elsworth, L Mintz, TL Horvath
Molecular Metabolism 2019
A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease
RL Mosley, Y Lu, KE Olson, J Machhi, W Yan, KL Namminga, JR Smith, SJ Shandler, HE Gendelman
Frontiers in cellular neuroscience 2019
Protective and Regenerative Roles of T Cells in Central Nervous System Disorders
FL Evans, M Dittmer, AG de la Fuente, DC Fitzgerald
Frontiers in immunology 2019
Innate and adaptive immune responses in Parkinson's disease
Aubrey M Schonhoff, Gregory P Williams, Zachary D Wallen, David G Standaert, Ashley S Harms
Progress in brain research 2019
Heat-Shock Proteins in Neuroinflammation
B Dukay, B Csoboz, ME Tóth
Frontiers in pharmacology 2019
Roles for the adaptive immune system in Parkinson’s and Alzheimer’s diseases
CS Arlehamn, F Garretti, D Sulzer, A Sette
Current Opinion in Immunology 2019
Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1
S Nataf, M Guillen, L Pays
Frontiers in immunology 2019
B cells in autoimmune and neurodegenerative central nervous system diseases
JJ Sabatino, AK Pröbstel, SS Zamvil
Nature Reviews Neuroscience 2019
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
Zuo, Prather, Stetskiv, Garrison, Meade, Peace, Zhou
International journal of molecular sciences 2019
Immune Signaling in Neurodegeneration
TR Hammond, SE Marsh, B Stevens
Immunity 2019
Association of LAG3 genetic variation with an increased risk of PD in Chinese female population
W Guo, M Zhou, J Qiu, Y Lin, X Chen, S Huang, M Mo, H Liu, G Peng, X Zhu, P Xu
Journal of Neuroinflammation 2019
Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease
SM Matt, PJ Gaskill
Journal of Neuroimmune Pharmacology 2019
Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice
A Yan, Z Liu, L Song, X Wang, Y Zhang, N Wu, J Lin, Y Liu, Z Liu
Frontiers in cellular neuroscience 2019
Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age
RR Martins, PS Ellis, RB MacDonald, RJ Richardson, CM Henriques
Frontiers in Cell and Developmental Biology 2019
Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence
E Storelli, N Cassina, E Rasini, F Marino, M Cosentino
Frontiers in neurology 2019
Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway
YL Yang, X Cheng, WH Li, M Liu, YH Wang, GH Du
International journal of molecular sciences 2019
T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis
N Don-Doncow, L Vanherle, Y Zhang, A Meissner
International journal of molecular sciences 2019
Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease
X Xue, W Zhang, J Zhu, X Chen, S Zhou, Z Xu, G Hu, C Su
Journal of Cellular and Molecular Medicine 2019
T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease
J Campos-Acuña, D Elgueta, R Pacheco
Frontiers in immunology 2019
Inflammation, Infectious Triggers, and Parkinson's Disease
E Caggiu, G Arru, S Hosseini, M Niegowska, GP Sechi, IR Zarbo, LA Sechi
Frontiers in neurology 2019
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells
F Garretti, D Agalliu, CS Arlehamn, A Sette, D Sulzer
Frontiers in immunology 2019
Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?
MT Fuzzati-Armentero, S Cerri, F Blandini
Frontiers in neurology 2019
Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A2 Against MPTP-Induced Parkinson’s Disease in Mice
KH Kim, SY Lee, J Shin, JT Hwang, HN Jeon, H Bae
Frontiers in aging neuroscience 2019
Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook
B Olson, DL Marks
Cancers 2019
Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model
D Elgueta, F Contreras, C Prado, A Montoya, V Ugalde, O Chovar, R Villagra, C Henríquez, MA Abellanas, MS Aymerich, R Franco, R Pacheco
Frontiers in immunology 2019
Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat
KL Patrick, SL Bell, CG Weindel, RO Watson
Frontiers in Cellular and Infection Microbiology 2019
Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA2 Compositions in a Mouse Model of Parkinson’s Disease
KH Kim, M Kim, J Lee, HN Jeon, SH Kim, H Bae
Toxins 2019
Parkinson’s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation
SK Dutta, S Verma, V Jain, BK Surapaneni, R Vinayek, L Phillips, PP Nair
Journal of Neurogastroenterology and Motility 2019
Widespread Tau-Specific CD4 T Cell Reactivity in the General Population
CS Arlehamn, J Pham, RN Alcalay, A Frazier, E Shorr, C Carpenter, J Sidney, R Dhanwani, J Agin-Liebes, F Garretti, AW Amara, DG Standaert, EJ Phillips, SA Mallal, B Peters, D Sulzer, A Sette
Journal of immunology (Baltimore, Md. : 1950) 2019
Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation
D Dai, J Yuan, Y Wang, J Xu, C Mao, Y Xiao
Scientific Reports 2019
Probiotics for Parkinson’s Disease
Gazerani
International journal of molecular sciences 2019
Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease
QQ Chen, C Haikal, W Li, JY Li
Frontiers in molecular neuroscience 2019
Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys
S Mondal, SB Rangasamy, A Roy, S Dasarathy, JH Kordower, K Pahan
Journal of immunology (Baltimore, Md. : 1950) 2019
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses
C Garber, A Soung, LL Vollmer, M Kanmogne, A Last, J Brown, RS Klein
Nature Neuroscience 2019
RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson's disease
D Dutta, M Kundu, S Mondal, A Roy, S Ruehl, DA Hall, K Pahan
Neurobiology of Disease 2019
Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions
S Kalampokini, A Becker, K Fassbender, E Lyros, MM Unger
Parkinson's Disease 2019
Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
C Perner, F Perner, N Gaur, S Zimmermann, OW Witte, FH Heidel, J Grosskreutz, T Prell
Journal of Neuroinflammation 2019
Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism
J Gong, ÉM Szego, A Leonov, E Benito, S Becker, A Fischer, M Zweckstetter, T Outeiro, A Schneider
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019
Role of MicroRNAs in Parkinson’s Disease
SY Goh, YX Chao, ST Dheen, EK Tan, SS Tay
International journal of molecular sciences 2019
Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease
E Palasz, W Niewiadomski, A Gasiorowska, A Wysocka, A Stepniewska, G Niewiadomska
Frontiers in neurology 2019
18 F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis
BY Chen, C Ghezzi, B Villegas, A Quon, CG Radu, ON Witte, PM Clark
Journal of Nuclear Medicine 2019
Targeting the Dopaminergic System in Autoimmunity
PM Vidal, R Pacheco
Journal of Neuroimmune Pharmacology 2019
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
RH Earls, KB Menees, J Chung, J Barber, CA Gutekunst, MG Hazim, JK Lee
Journal of Neuroinflammation 2019
Microbiome changes: an indicator of Parkinson's disease?
Haikal C, Chen QQ, Li JY
Translational Neurodegeneration 2019
Dysregulated Long Non-coding RNAs in Parkinson's Disease Contribute to the Apoptosis of Human Neuroblastoma Cells.
Fan Y, Li J, Yang Q, Gong C, Gao H, Mao Z, Yuan X, Zhu S, Xue Z
Frontiers in neuroscience 2019
Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson's disease.
Sun C, Zhao Z, Yu W, Mo M, Song C, Si Y, Liu Y
Annals of translational medicine 2019
Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
Anssar TM, Leitzmann MF, Linker RA, Meier C, Becker C, Jick S, Sahm K, Platten M, Hau P, Seliger C
Cancer Medicine 2019
Peripheral immune biomarkers and neurodegenerative diseases - a prospective cohort study with 20 years of follow-up
Yazdani S, Mariosa D, Hammar N, Andersson J, Ingre C, Walldius G, Fang F
Annals of Neurology 2019
The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?
Killinger B, Labrie V
Journal of Parkinson's disease 2019
Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced Parkinsonian mouse model.
Kim SJ, Ryu MJ, Han J, Jang Y, Lee MJ, Ju X, Ryu I, Lee YL, Oh E, Chung W, Heo JY, Kweon GR
Laboratory Investigation 2019
Infection triggers symptoms similar to those of Parkinson's disease in mice lacking PINK1 protein.
Herrick MK, Tansey MG
Nature 2019
Blood-brain barrier opening with focused ultrasound in experimental models of Parkinson's disease.
Karakatsani ME, Blesa J, Konofagou EE
Movement disorders : official journal of the Movement Disorder Society 2019
Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort
Lawton M, Baig F, Toulson G, Morovat A, Evetts SG, Ben\u2010Shlomo Y, Hu MT
Movement Disorders 2019
Microglial interactions with the neurovascular system in physiology and pathology: Microglia-Vascular Communication
X Zhao, UB Eyo, M Murugan, LJ Wu
Developmental Neurobiology 2018
The Role of Immunosenescence in Neurodegenerative Diseases
E Costantini, C DAngelo, M Reale
Mediators of Inflammation 2018
Neuroinflammation: Microglia and T Cells Get Ready to Tango
ST Schetters, D Gomez-Nicola, JJ Garcia-Vallejo, YV Kooyk
Frontiers in immunology 2018
Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases
P García-González, F Cabral-Miranda, C Hetz, F Osorio
Frontiers in immunology 2018
Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson’s Disease
Y Jiang, Z Cao, H Ma, G Wang, X Wang, Z Wang, Y Yang, H Zhao, G Liu, L Li, T Feng
Neurochemical Research 2018
New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
G Zhang, Y Xia, F Wan, K Ma, X Guo, L Kou, S Yin, C Han, L Liu, J Huang, N Xiong, T Wang
Frontiers in aging neuroscience 2018
Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
AS Harms, AD Thome, Z Yan, AM Schonhoff, GP Williams, X Li, Y Liu, H Qin, EN Benveniste, DG Standaert
Experimental Neurology 2018
Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain
F L'Episcopo, C Tirolo, MF Serapide, S Caniglia, N Testa, L Leggio, S Vivarelli, N Iraci, S Pluchino, B Marchetti
Frontiers in aging neuroscience 2018
Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients
N Kustrimovic, C Comi, L Magistrelli, E Rasini, M Legnaro, R Bombelli, I Aleksic, F Blandini, B Minafra, G Riboldazzi, A Sturchio, M Mauri, G Bono, F Marino, M Cosentino
Journal of Neuroinflammation 2018
α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
LM Butkovich, MC Houser, MG Tansey
Frontiers in neuroscience 2018
Partial Depletion of Peripheral M1 Macrophages Reverses Motor Deficits in MPTP-Treated Mouse by Suppressing Neuroinflammation and Dopaminergic Neurodegeneration
A Yan, Y Zhang, J Lin, L Song, X Wang, Z Liu
Frontiers in aging neuroscience 2018
Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease
CR Schutt, HE Gendelman, RL Mosley
Molecular Neurodegeneration 2018
Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
C Ising, MT Heneka
Cell Death and Disease 2018
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells
F Osorio-Barrios, C Prado, F Contreras, R Pacheco
Frontiers in cellular neuroscience 2018
Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
SA Ferreira, M Romero-Ramos
Frontiers in cellular neuroscience 2018
Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
V Ghiglieri, V Calabrese, P Calabresi
Frontiers in neurology 2018
Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
G Gelders, V Baekelandt, AV der Perren
Journal of Immunology Research 2018
Emerging Biosensing Technologies for Neuroinflammatory and Neurodegenerative Disease Diagnostics
CM Abreu, R Soares-dos-Reis, PN Melo, JB Relvas, J Guimarães, MJ Sá, AP Cruz, IM Pinto
Frontiers in molecular neuroscience 2018
Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction
Y Liu, Y Yin
Mediators of Inflammation 2018
Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases
AU Joshi, D Mochly-Rosen
Pharmacological research : the official journal of the Italian Pharmacological Society 2018
CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology
MN Olesen, JR Christiansen, SV Petersen, PH Jensen, W Paslawski, M Romero-Ramos, V Sanchez-Guajardo
Heliyon 2018
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease
GP Williams, AM Schonhoff, A Jurkuvenaite, AD Thome, DG Standaert, AS Harms
Journal of Neuroinflammation 2018
NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson’s disease
KM von Herrmann, LA Salas, EM Martinez, AL Young, JM Howard, MS Feldman, BC Christensen, OM Wilkins, SL Lee, WF Hickey, MC Havrda
npj Parkinson's Disease 2018
Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo
E Bok, YC Chung, KS Kim, HH Baik, WH Shin, BK Jin
Experimental & molecular medicine 2018
NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson’s Disease
R Sirabella, MJ Sisalli, G Costa, K Omura, G Ianniello, A Pinna, M Morelli, GM Renzo, L Annunziato, A Scorziello
Cell Death and Disease 2018
Abnormalities of age-related T cell senescence in Parkinson’s disease
CH Williams-Gray, RS Wijeyekoon, KM Scott, S Hayat, RA Barker, JL Jones
Journal of Neuroinflammation 2018
Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion
EG Hain, M Sparenberg, J Rasińska, C Klein, L Akyüz, B Steiner
Journal of Neuroinflammation 2018
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
MF Duffy, TJ Collier, JR Patterson, CJ Kemp, KC Luk, MG Tansey, KL Paumier, NM Kanaan, DL Fischer, NK Polinski, OL Barth, JW Howe, NN Vaikath, NK Majbour, OM El-Agnaf, CE Sortwell
Journal of Neuroinflammation 2018
Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice
KE Olson, AN Bade, KL Namminga, MJ Potash, RL Mosley, LY Poluektova, DJ Volsky, HE Gendelman
Journal of Neurovirology 2018
Depletion of microglia augments the dopaminergic neurotoxicity of MPTP
X Yang, H Ren, K Wood, M Li, S Qiu, FD Shi, C Ma, Q Liu
The FASEB Journal 2018
Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
R Hussain, H Zubair, S Pursell, M Shahab
Brain Sciences 2018
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
MS Unger, P Schernthaner, J Marschallinger, H Mrowetz, L Aigner
Journal of Neuroinflammation 2018
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
T Jiang, Li, J Xu, S Gao, X Chen
Frontiers in immunology 2018
Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment
PL Chiang, HL Chen, CH Lu, YS Chen, KH Chou, TW Hsu, MH Chen, NW Tsai, SH Li, WC Lin
Journal of Neuroinflammation 2018
Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
P Troncoso-Escudero, A Parra, M Nassif, RL Vidal
Frontiers in neurology 2018
Neuroimmunological Implications of Subclinical Lipopolysaccharide from Salmonella Enteritidis
A Mikołajczyk, D Złotkowska
International journal of molecular sciences 2018
Th17 lymphocyte spearheads the immune attack in Parkinson's disease: New evidence for neuronal death
AW Shukla, SH Fox
Movement disorders : official journal of the Movement Disorder Society 2018
Curative Anti-Inflammatory Properties of Chinese Optimized Yinxieling Formula in Models of Parkinson’s Disease
RR Wei, J OuYang, WX Lin, TX Lin
Evidence-Based Complementary and Alternative Medicine 2018
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
I García-Domínguez, K Veselá, J García-Revilla, A Carrillo-Jiménez, MA Roca-Ceballos, M Santiago, RM de Pablos, JL Venero
Frontiers in cellular neuroscience 2018
Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease
JB Schröder, M Pawlowski, GM zu Hörste, CC Gross, H Wiendl, SG Meuth, T Ruck, T Warnecke
Frontiers in neurology 2018
Counteracting neuroinflammation in experimental Parkinson’s disease favors recovery of function: effects of Er-NPCs administration
S Carelli, T Giallongo, Z Gombalova, F Rey, MC Gorio, M Mazza, AM Giulio
Journal of Neuroinflammation 2018
Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells
YQ Guan, CS Zhao, HQ Zou, XM Yan, LL Luo, JL Wu, X Li, Y Zhang
Molecular medicine reports 2018
Immune system responses in Parkinson's disease: Early and dynamic
MG Tansey, M RomeroRamos
The European journal of neuroscience 2018
Early microglial activation and peripheral inflammation in dementia with Lewy bodies
A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, PV Rodríguez, WR Bevan-Jones, SA Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT OBrien
Brain 2018
Microbial treatment: the potential application for Parkinson's disease.
Fang X
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2018
Effective effectors: How T cells access and infiltrate the central nervous system.
Congdon KL, Sanchez-Perez LA, Sampson JH
Pharmacology & Therapeutics 2018
α-Synuclein activates innate immunity but suppresses interferon-γ expression in murine astrocytes.
Wang J, Chen Z, Walston JD, Gao P, Gao M, Leng SX
The European journal of neuroscience 2018
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Kozina E, Sadasivan S, Jiao Y, Dou Y, Ma Z, Tan H, Kodali K, Shaw T, Peng J, Smeyne RJ
Brain : a journal of neurology 2018
Prion-like mechanisms in Parkinson Disease
Volpicelli-Daley L, Brundin P
Handbook of Clinical Neurology 2018
Th17 cells in Parkinson’s disease: the bane of the midbrain
Bolte AC, Lukens JR
Cell Stem Cell 2018
CNS inflammation and neurodegeneration
Tanuja Chitnis, Howard L. Weiner
Journal of Clinical Investigation 2017
Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease
JA Korecka, EB Moloney, R Eggers, B Hobo, S Scheffer, N Ras-Verloop, RJ Pasterkamp, DF Swaab, AB Smit, RE van Kesteren, K Bossers, J Verhaagen
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease
SR Stott, S Hayat, T Carnwath, S Garas, JP Sleeman, RA Barker, RJ Smeyne
PloS one 2017
The Oxygen Paradox, the French Paradox, and age-related diseases
JM Davies, J Cillard, B Friguet, E Cadenas, J Cadet, R Cayce, A Fishmann, D Liao, AL Bulteau, F Derbré, A Rébillard, S Burstein, E Hirsch, RA Kloner, M Jakowec, G Petzinger, D Sauce, F Sennlaub, I Limon, F Ursini, M Maiorino, C Economides, CJ Pike, P Cohen, AN Salvayre, MR Halliday, AJ Lundquist, NA Jakowec, F Mechta-Grigoriou, M Mericskay, J Mariani, Z Li, D Huang, E Grant, HJ Forman, CE Finch, PY Sun, LC Pomatto, O Agbulut, D Warburton, C Neri, M Rouis, P Cillard, J Capeau, J Rosenbaum, KJ Davies
GeroScience 2017
Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism
A Anandhan, MS Jacome, S Lei, P Hernandez-Franco, A Pappa, MI Panayiotidis, R Powers, R Franco
Brain Research Bulletin 2017
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
A Terron, A Bal-Price, A Paini, F Monnet-Tschudi, SH Bennekou, M Leist, S Schildknecht
Archives of Toxicology 2017
Let’s make microglia great again in neurodegenerative disorders
MV Guillot-Sestier, T Town
Journal of Neural Transmission 2017
Autoimmune Aspects of Neurodegenerative and Psychiatric Diseases: A Template for Innovative Therapy
P Haan, HC Klein, BA Hart
Frontiers in Psychiatry 2017
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
D Sulzer, RN Alcalay, F Garretti, L Cote, E Kanter, J Agin-Liebes, C Liong, C McMurtrey, WH Hildebrand, X Mao, VL Dawson, TM Dawson, C Oseroff, J Pham, J Sidney, MB Dillon, C Carpenter, D Weiskopf, E Phillips, S Mallal, B Peters, A Frazier, CS Arlehamn, A Sette
Nature 2017
Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat
G Ambrosi, N Kustrimovic, F Siani, E Rasini, S Cerri, C Ghezzi, G Dicorato, S Caputo, F Marino, M Cosentino, F Blandini
Neurotoxicity Research 2017
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
RH Swerdlow, HM Wilkins, IW Weidling, Y Ji
Frontiers in immunology 2017
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
SR Subramaniam, HJ Federoff
Frontiers in aging neuroscience 2017
Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
P Thakur, LS Breger, M Lundblad, OW Wan, B Mattsson, KC Luk, VM Lee, JQ Trojanowski, A Björklund
Proceedings of the National Academy of Sciences 2017
Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes
VR Parillaud, G Lornet, Y Monnet, AL Privat, AT Haddad, V Brochard, A Bekaert, CB de Chanville, EC Hirsch, C Combadière, S Hunot, CS Lobsiger
Journal of Neuroinflammation 2017
Peripheral Lymphocyte Subsets as a Marker of Parkinson’s Disease in a Chinese Population
L Cen, C Yang, S Huang, M Zhou, X Tang, K Li, W Guo, Z Wu, M Mo, Y Xiao, X Chen, X Yang, Q Huang, C Chen, S Qu, P Xu
Neuroscience Bulletin 2017
Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson’s disease trial
HE Gendelman, Y Zhang, P Santamaria, KE Olson, CR Schutt, D Bhatti, BL Shetty, Y Lu, KA Estes, DG Standaert, E Heinrichs-Graham, LA Larson, JL Meza, M Follett, E Forsberg, G Siuzdak, TW Wilson, C Peterson, RL Mosley
npj Parkinson's Disease 2017
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease
Q Zhang, Y Heng, Z Mou, J Huang, Y Yuan, N Chen
Acta Pharmacologica Sinica 2017
Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila
SC Wu, ZS Cao, KM Chang, JL Juang
Nature Communications 2017
Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease
G Chandra, A Roy, SB Rangasamy, K Pahan
Journal of immunology (Baltimore, Md. : 1950) 2017
KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels
JY Choi, SS Yoon, SE Kim, SA Jo
Scientific Reports 2017
A Novel Immunosuppressor, (5R)-5-Hydroxytriptolide, Alleviates Movement Disorder and Neuroinflammation in a 6-OHDA Hemiparkinsonian Rat Model
R Su, M Sun, W Wang, J Zhang, L Zhang, J Zhen, Y Qian, Y Zheng, X Wang
Aging and disease 2017
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease
H Lee, WS James, SA Cowley
Biochemical Society Transactions 2017
Autoimmunity as a Driving Force of Cognitive Evolution
S Nataf
Frontiers in neuroscience 2017
The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
A Sommer, B Winner, I Prots
Molecular Neurodegeneration 2017
Vanishing cerebral vasculitis in a patient with Lewy pathology
Natalia Liapounova, Kamran H Azar, J Max Findlay, Jian-Qiang Lu
Journal of Biomedical Research 2017
The role of peripheral immune cells in the CNS in steady state and disease
M Prinz, J Priller
Nature Neuroscience 2017
Evidence for association between hepatitis C virus and Parkinson's disease.
Abushouk AI, El-Husseny MWA, Magdy M, Ismail A, Attia A, Ahmed H, Pallanti R, Negida A
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2017
TGF-β1 Neuroprotection via Inhibition of Microglial Activation in a Rat Model of Parkinson's Disease.
Chen X, Liu Z, Cao BB, Qiu YH, Peng YP
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2017
Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson’s Disease Patients: Search for a Disease Indicator
Yang L, Guo C, Zhu J, Feng Y, Chen W, Feng Z, Wang D, Sun S, Lin W, Wang Y
Medical science monitor : international medical journal of experimental and clinical research 2017
The correlation of lymphocyte subsets, natural killer cell, and Parkinson's disease: a meta-analysis.
Jiang S, Gao H, Luo Q, Wang P, Yang X
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2017
Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases
Z Yan, SA Gibson, JA Buckley, H Qin, EN Benveniste
Clinical Immunology 2016
Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson’s Disease-Lessons from Transgenic Mice
V Machado, T Zöller, A Attaai, B Spittau
International journal of molecular sciences 2016
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease
LC Graham, JM Harder, I Soto, WN de Vries, SW John, GR Howell
Scientific Reports 2016
Immune-mediated processes in neurodegeneration: where do we stand?
M Fakhoury
Journal of Neurology 2016
CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson’s disease
YC Chung, WH Shin, JY Baek, EJ Cho, HH Baik, SR Kim, SY Won, BK Jin
Experimental & molecular medicine 2016
Protective Microglia and Their Regulation in Parkinson’s Disease
W Le, J Wu, Y Tang
Frontiers in molecular neuroscience 2016
Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases
DG Walker, LF Lue, G Serrano, CH Adler, JN Caviness, LI Sue, TG Beach
Frontiers in neuroscience 2016
Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson’s Disease
N Kustrimovic, E Rasini, M Legnaro, R Bombelli, I Aleksic, F Blandini, C Comi, M Mauri, B Minafra, G Riboldazzi, V Sanchez-Guajardo, F Marino, M Cosentino
Scientific Reports 2016
Pink Light on Mitochondria in Autoimmunity and Parkinson Disease
AR Mantegazza, MS Marks
Cell Metabolism 2016
Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model
A Sommer, T Fadler, E Dorfmeister, AC Hoffmann, W Xiang, B Winner, I Prots
Journal of Neuroinflammation 2016
Manganese-Enhanced Magnetic Resonance Imaging for Detection of Vasoactive Intestinal Peptide Receptor 2 Agonist Therapy in a Model of Parkinson’s Disease
KE Olson, AN Bade, CR Schutt, J Dong, SJ Shandler, MD Boska, RL Mosley, HE Gendelman, Y Liu
Neurotherapeutics 2016
Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons
S Wang, CH Chu, M Guo, L Jiang, H Nie, W Zhang, B Wilson, L Yang, T Stewart, JS Hong, J Zhang
Journal of Neuroinflammation 2016
Central Nervous System-Peripheral Immune System Dialogue in Neurological Disorders: Possible Application of Neuroimmunology in Urology
HS Park, MJ Park, MS Kwon
International Neurourology Journal 2016
Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease
G Chandra, SB Rangasamy, A Roy, JH Kordower, K Pahan
The Journal of biological chemistry 2016
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease
R Gordon, N Singh, V Lawana, A Ghosh, DS Harischandra, H Jin, C Hogan, S Sarkar, D Rokad, N Panicker, V Anantharam, AG Kanthasamy, A Kanthasamy
Neurobiology of Disease 2016
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology
JR Christiansen, MN Olesen, DE Otzen, M Romero-Ramos, V Sanchez-Guajardo
Journal of Neuroinflammation 2016
Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes
MK Shimabukuro, LG Langhi, I Cordeiro, JM Brito, CM de Batista, MP Mattson, VM Coelho
Scientific Reports 2016
Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD): Serum Immune Markers and PD Progression
CH Williams-Gray, R Wijeyekoon, AJ Yarnall, RA Lawson, DP Breen, JR Evans, GA Cummins, GW Duncan, TK Khoo, DJ Burn, RA Barker
Movement disorders : official journal of the Movement Disorder Society 2016
Microglia-Derived Cytokines/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice
CH Chien, MJ Lee, HC Liou, HH Liou, WM Fu, ML Block
PloS one 2016
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease
AD Thome, AS Harms, LA Volpicelli-Daley, DG Standaert
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies
IL González, P Garcia-Esparcia, F Llorens, I Ferrer
International journal of molecular sciences 2016
Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms
C Figueroa-Romero, J Hur, JS Lunn, X Paez-Colasante, DE Bender, R Yung, SA Sakowski, EL Feldman
Molecular and Cellular Neuroscience 2016
Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease
KE Olson, HE Gendelman
Current Opinion in Pharmacology 2016
Serum Lymphocyte-Associated Cytokine Concentrations Change More Rapidly over Time in Multiple System Atrophy Compared to Parkinson Disease
K Csencsits-Smith, J Suescun, K Li, S Luo, DL Bick, M Schiess
Neuroimmunomodulation 2016
Rho kinase II interference by small hairpin RNA ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
Q Zhang, YF Zhao, JY Xi, WB Yu, BG Xiao
Molecular medicine reports 2016
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration
H Qin, JA Buckley, X Li, Y Liu, TH Fox, GP Meares, H Yu, Z Yan, AS Harms, Y Li, DG Standaert, EN Benveniste
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model
N Tentillier, A Etzerodt, MN Olesen, FS Rizalar, J Jacobsen, D Bender, SK Moestrup, M Romero-Ramos
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson's Disease.
Liu Z, Huang Y, Cao BB, Qiu YH, Peng YP
Molecular Neurobiology 2016
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
LJ Blair, HD Frauen, B Zhang, BA Nordhues, S Bijan, YC Lin, F Zamudio, LD Hernandez, JJ Sabbagh, ML Selenica, CA Dickey
Acta Neuropathologica Communications 2015
Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging
B Coder, W Wang, L Wang, Z Wu, Q Zhuge, DM Su
Oncotarget 2015
Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes
EH Rannikko, SS Weber, PJ Kahle
BMC neuroscience 2015
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
C Späni, T Suter, R Derungs, MT Ferretti, T Welt, F Wirth, C Gericke, RM Nitsch, L Kulic
Acta Neuropathologica Communications 2015
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
B Dehay, M Bourdenx, P Gorry, S Przedborski, M Vila, S Hunot, A Singleton, CW Olanow, KM Merchant, E Bezard, GA Petsko, WG Meissner
The Lancet Neurology 2015
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
AJ Herrera, AM Espinosa-Oliva, A Carrillo-Jiménez, MJ Oliva-Martín, J García-Revilla, A García-Quintanilla, RM de Pablos, JL Venero
Frontiers in cellular neuroscience 2015
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
FA Zucca, J Segura-Aguilar, E Ferrari, P Muñoz, I Paris, D Sulzer, T Sarna, L Casella, L Zecca
Progress in Neurobiology 2015
Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8+ T cells in the nigra of hemiparkinsonian monkey
A Roy, S Mondal, JH Kordower, K Pahan
Neuroscience 2015
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
L Gao, D Brenner, E Llorens-Bobadilla, G Saiz-Castro, T Frank, P Wieghofer, O Hill, M Thiemann, S Karray, M Prinz, JH Weishaupt, A Martin-Villalba
Journal of Experimental Medicine 2015
Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease
M Shahaduzzaman, K Nash, C Hudson, M Sharif, B Grimmig, X Lin, G Bai, H Liu, KE Ugen, C Cao, PC Bickford
PloS one 2015
Effects of inflammation on stem cells: together they strive?
C Kizil, N Kyritsis, M Brand
EMBO reports 2015
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease
Heather E. Allen Reish, David G. Standaert
Journal of Parkinson's disease 2015
Low-variance RNAs identify Parkinson's disease molecular signature in blood: New Blood Biomarkers of PD
MD Chikina, CP Gerald, X Li, Y Ge, H Pincas, VD Nair, AK Wong, A Krishnan, OG Troyanskaya, D Raymond, R Saunders-Pullman, SB Bressman, Z Yue, SC Sealfon
Movement disorders : official journal of the Movement Disorder Society 2015
Striatal blood–brain barrier permeability in Parkinson’s disease
MT Gray, JM Woulfe
Journal of Cerebral Blood Flow & Metabolism 2015
Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration
S Theofilopoulos, E Arenas
F1000prime reports 2015
Immune aging, dysmetabolism, and inflammation in neurological diseases
M Deleidi, M Jäggle, G Rubino
Frontiers in neuroscience 2015
Baseline C-Reactive Protein Levels and Life Prognosis in Parkinson Disease
H Sawada, T Oeda, A Umemura, S Tomita, M Kohsaka, K Park, K Yamamoto, H Sugiyama, K Hashimoto
PloS one 2015
Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model
R Dutta, S Roy
Journal of Neuroinflammation 2015
Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice
S Samantaray, VH Knaryan, DC Shields, AA Cox, A Haque, NL Banik
Molecular Neurobiology 2015
Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
Q Wang, Y Liu, J Zhou
Translational Neurodegeneration 2015
Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease
KE Ugen, X Lin, G Bai, Z Liang, J Cai, K Li, S Song, C Cao, J Sanchez-Ramos
Human Vaccines & Immunotherapeutics 2015
Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS?
B Almolda, B González, B Castellano
Frontiers in cellular neuroscience 2015
Myeloid Dendritic Cells are Potential Players in Human Neurodegenerative Diseases
P Bossù, G Spalletta, C Caltagirone, A Ciaramella
Frontiers in immunology 2015
Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study
GT Kannarkat, DA Cook, JK Lee, J Chang, J Chung, E Sandy, KC Paul, B Ritz, J Bronstein, SA Factor, JM Boss, MG Tansey
npj Parkinson's Disease 2015
Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice
KE Olson, LM Kosloski-Bilek, KM Anderson, BJ Diggs, BE Clark, JM Gledhill, SJ Shandler, RL Mosley, HE Gendelman
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Substance P and its tachykinin NK1 receptor: a novel neuroprotective target for Parkinson′s disease
E Thornton, R Vink
NEURAL REGEN RES 2015
Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease: MHC II Ablation Attenuates MPTP Toxicity
HL Martin, M Santoro, S Mustafa, G Riedel, JV Forrester, P Teismann
Glia 2015
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease
AD Thome, DG Standaert, AS Harms, MG Tansey
PloS one 2015
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
P Ejlerskov, JG Hultberg, JY Wang, R Carlsson, M Ambjørn, M Kuss, Y Liu, G Porcu, K Kolkova, C Friis Rundsten, K Ruscher, B Pakkenberg, T Goldmann, D Loreth, M Prinz, DC Rubinsztein, S Issazadeh-Navikas
Cell 2015
Parkinson’s disease and enhanced inflammatory response
I Stojkovska, BM Wagner, BE Morrison
Experimental biology and medicine (Maywood, N.J.) 2015
Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells
H González, F Contreras, R Pacheco
Journal of Neuroimmune Pharmacology 2015
The Role of Neuroinflammation in Dementias
G Pasqualetti, DJ Brooks, P Edison
Current Neurology and Neuroscience Reports 2015
New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation.
Trudler D, Nash Y, Frenkel D
Journal of neural transmission (Vienna, Austria : 1996) 2015
Adaptive Immunity in Schizophrenia: Functional Implications of T Cells in the Etiology, Course and Treatment.
Debnath M
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2015
Lymphocytes reduce nigrostriatal deficits in the 6-hydroxydopamine mouse model of Parkinson's disease.
Ip CW, Beck SK, Volkmann J
Journal of neural transmission (Vienna, Austria : 1996) 2015
Nanowire array chips for molecular typing of rare trafficking leukocytes with application to neurodegenerative pathology
M Kwak, DJ Kim, MR Lee, Y Wu, L Han, SK Lee, R Fan
Nanoscale 2014
The Dopaminergic System in Autoimmune Diseases
R Pacheco, F Contreras, M Zouali
Frontiers in immunology 2014
T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases
H González, R Pacheco
Journal of Neuroinflammation 2014
The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease
MA Lynch
Immunology 2014
The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
KR Doty, MV Guillot-Sestier, T Town
Brain Research 2014
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
C Cebrián, FA Zucca, P Mauri, JA Steinbeck, L Studer, CR Scherzer, E Kanter, S Budhu, J Mandelbaum, JP Vonsattel, L Zecca, JD Loike, D Sulzer
Nature Communications 2014
Immune Responses in Parkinson's Disease: Interplay between Central and Peripheral Immune Systems
X Su, HJ Federoff
BioMed Research International 2014
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
G Olmos, J Lladó
Mediators of Inflammation 2014
Opposite effects of bone marrow-derived cells transplantation in MPTP-rat model of Parkinson's disease: a comparison study of mononuclear and mesenchymal stem cells
CS Capitelli, CS Lopes, AC Alves, J Barbiero, LF Oliveira, VJ da Silva, MA Vital
International journal of medical sciences 2014
Evidence of inflammatory system involvement in Parkinson's disease
Y Chao, SC Wong, EK Tan
BioMed Research International 2014
Damage of neuroblastoma cell SH-SY5Y mediated by MPP+ inhibits proliferation of T-cell leukemia Jurkat by co-culture system
F Wang, UF Awan, Y Wang, L Wang, H Qing, H Ma, Y Deng
International journal of molecular sciences 2014
Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease
F L’Episcopo, C Tirolo, S Caniglia, N Testa, MC Morale, MF Serapide, S Pluchino, B Marchetti
Journal of Molecular Cell Biology 2014
Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases
C Cebrián, JD Loike, D Sulzer
Frontiers in neuroanatomy 2014
Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders
KM Anderson, KE Olson, KA Estes, K Flanagan, HE Gendelman, R Mosley
Translational Neurodegeneration 2014
T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson’s Disease
CJ Wheeler
Journal of Neurology & Neurophysiology 2014
Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
V Grozdanov, C Bliederhaeuser, WP Ruf, V Roth, K Fundel-Clemens, L Zondler, D Brenner, A Martin-Villalba, B Hengerer, J Kassubek, AC Ludolph, JH Weishaupt, KM Danzer
Acta Neuropathologica 2014
Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype: Immunization with Hsp70-Chaperoned α-Synuclein
A Labrador-Garrido, M Cejudo-Guillén, R Klippstein, EJ de Genst, L Tomas-Gallardo, MM Leal, J Villadiego, JJ Toledo-Aral, CM Dobson, D Pozo, C Roodveldt
Immunity, Inflammation and Disease 2014
Microglia Development and Function*
D Nayak, TL Roth, DB McGavern
Annual Review of Immunology 2014
Vaccination strategies for Parkinson disease: Induction of a swift attack or raising tolerance?
Romero-Ramos M, von Euler Chelpin M, Sanchez-Guajardo V
Human Vaccines & Immunotherapeutics 2014
Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent.
Garcia-Esparcia P, Llorens F, Carmona M, Ferrer I
Brain Pathology 2014
MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration
AS Harms, S Cao, AL Rowse, AD Thome, X Li, LR Mangieri, RQ Cron, JJ Shacka, C Raman, DG Standaert
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
The role of inflammation in sporadic and familial Parkinson’s disease
M Deleidi, T Gasser
Cellular and Molecular Life Sciences 2013
Viruses and neurodegeneration
L Zhou, M Miranda-Saksena, NK Saksena
Virology Journal 2013
Integrating pathways of Parkinson's disease in a molecular interaction map
KA Fujita, M Ostaszewski, Y Matsuoka, S Ghosh, E Glaab, C Trefois, I Crespo, TM Perumal, W Jurkowski, PM Antony, N Diederich, M Buttini, A Kodama, VP Satagopam, S Eifes, AD Sol, R Schneider, H Kitano, R Balling
Molecular Neurobiology 2013
Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease
F Blandini
Journal of Neuroimmune Pharmacology 2013
Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
G Laćan, H Dang, B Middleton, MA Horwitz, J Tian, WP Melega, DL Kaufman
Journal of Neuroscience Research 2013
Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
F Rizzo, G Riboldi, S Salani, M Nizzardo, C Simone, S Corti, E Hedlund
Experientia 2013
Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation
C Barcia, I Mitxitorena, MA Sauvage, JM Gallego, A Pérez-Vallés, C Barcia
Frontiers in cellular neuroscience 2013
MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease
YC Chung, YS Kim, E Bok, TY Yune, S Maeng, BK Jin
Mediators of Inflammation 2013
Glial-mediated inflammation underlying parkinsonism
C Barcia
Scientifica 2013
Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease
SV More, H Kumar, IS Kim, SY Song, DK Choi
Mediators of Inflammation 2013
Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity
V Sanchez-Guajardo, CJ Barnum, MG Tansey, M Romero-Ramos
ASN NEURO 2013
PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice
MB Watson, H Nobuta, C Abad, SK Lee, N Bala, C Zhu, F Richter, MF Chesselet, JA Waschek
Neuroscience 2013
Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
C Noelker, L Morel, T Lescot, A Osterloh, D Alvarez-Fischer, M Breloer, C Henze, C Depboylu, D Skrzydelski, PP Michel, RC Dodel, L Lu, EC Hirsch, S Hunot, A Hartmann
Scientific Reports 2013
The role of innate and adaptive immunity in Parkinson's disease
GT Kannarkat, JM Boss, MG Tansey
Journal of Parkinson's disease 2013
GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice
LM Kosloski, EA Kosmacek, KE Olson, RL Mosley, HE Gendelman
Journal of Neuroimmunology 2013
Critical role of calpain in spinal cord degeneration in Parkinson's disease
S Samantaray, VH Knaryan, DC Shields, NL Banik
Journal of Neurochemistry 2013
Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function: Molecular immunology
GI Ellis, L Zhi, R Akundi, H Büeler, F Marti
European Journal of Immunology 2013
The immunology of neurodegeneration
Eva Czirr, Tony Wyss-Coray
Journal of Clinical Investigation 2012
Aspects of Innate Immunity and Parkinson’s Disease
Y Huang, GM Halliday
Frontiers in pharmacology 2012
Inflammation and Adaptive Immunity in Parkinson’s Disease
RL Mosley, JA Hutter-Saunders, DK Stone, HE Gendelman
Cold Spring Harbor Perspectives in Medicine 2012
Treatment with a Substance P Receptor Antagonist Is Neuroprotective in the Intrastriatal 6-Hydroxydopamine Model of Early Parkinson's Disease
E Thornton, R Vink
PloS one 2012
Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?
E Greggio, L Civiero, M Bisaglia, L Bubacco
Journal of Neuroinflammation 2012
Markov Chain Ontology Analysis (MCOA)
HR Frost, AT McCray
BMC bioinformatics 2012
A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
P Holmans, V Moskvina, L Jones, M Sharma, A Vedernikov, F Buchel, M Sadd, JM Bras, F Bettella, N Nicolaou, J Simon-Sanchez, F Mittag, JR Gibbs, C Schulte, A Durr, R Guerreiro, D Hernandez, A Brice, H Stefansson, K Majamaa, T Gasser, P Heutink, NW Wood, M Martinez, AB Singleton, MA Nalls, J Hardy, HR Morris, NM Williams, S Arepalli, R Barker, J Barrett, Y Ben-Shlomo, HW Berendse, D Berg, K Bhatia, RM de Bie, A Biffi, B Bloem, A Brice, Z Bochdanovits, M Bonin, JM Bras, K Brockmann, J Brooks, DJ Burn, G Charlesworth, H Chen, PF Chinnery, S Chong, CE Clarke, MR Cookson, JM Cooper, JC Corvol, C Counsell, P Damier, JF Dartigues, P Deloukas, G Deuschl, DT Dexter, KD van Dijk, A Dillman, F Durif, A Durr, S Edkins, JR Evans, T Foltynie, J Gao, M Gardner, T Gasser, JR Gibbs, A Goate, E Gray, R Guerreiro, O Gustafsson, J Hardy, C Harris, DG Hernandez, P Heutink, JJ van Hilten, A Hofman, A Hollenbeck, P Holmans, J Holton, M Hu, H Huber, G Hudson, SE Hunt, J Huttenlocher, T Illig, C Langford, A Lees, S Lesage, P Lichtner, P Limousin, G Lopez, D Lorenz, M Martinez, A McNeill, C Moorby, M Moore, H Morris, KE Morrison, V Moskvina, E Mudanohwo, MA Nalls, J Pearson, JS Perlmutter, H Petursson, V Plagnol, P Pollak, B Post, S Potter, B Ravina, T Revesz, O Riess, F Rivadeneira, P Rizzu, M Ryten, M Saad, S Sawcer, A Schapira, H Scheffer, M Sharma, K Shaw, UM Sheerin, I Shoulson, C Schulte, E Sidransky, J Simon-Sanchez, AB Singleton, C Smith, H Stefansson, K Stefansson, S Steinberg, JD Stockton, S Sveinbjornsdottir, K Talbot, CM Tanner, A Tashakkori-Ghanbaria, F Tison, D Trabzuni, BJ Traynor, AG Uitterlinden, D Velseboer, M Vidailhet, R Walker, B de Warrenburg, M Wickremaratchi, N Williams, CH Williams-Gray, S Winder-Rhodes, N Wood
Human Molecular Genetics 2012
Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage
WB Rolland, T Lekic, PR Krafft, Y Hasegawa, O Altay, R Hartman, R Ostrowski, A Manaenko, J Tang, JH Zhang
Experimental Neurology 2012
The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia
S Cao, DG Standaert, AS Harms
Journal of Neuroinflammation 2012
HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population
C Sun, L Wei, F Luo, Y Li, J Li, F Zhu, P Kang, R Xu, L Xiao, Z Liu, P Xu
PloS one 2012
The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease
JM Morganti, KR Nash, BA Grimmig, S Ranjit, B Small, PC Bickford, C Gemma
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Differential expression of nerve injury-induced protein 1 (ninjurin 1) in in vivo and in vitro models for diabetic erectile dysfunction
DK Kim, GN Yin, JK Ryu, JK Suh
Korean Journal of Urology 2012
CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease
JA Saunders, KA Estes, LM Kosloski, HE Allen, KM Dempsey, DR Torres-Russotto, JL Meza, PM Santamaria, JM Bertoni, DL Murman, HH Ali, DG Standaert, RL Mosley, HE Gendelman
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012
Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease
I St-Amour, M Bousquet, I Paré, J Drouin-Ouellet, F Cicchetti, R Bazin, F Calon
Journal of Neuroinflammation 2012
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
MB Watson, F Richter, SK Lee, L Gabby, J Wu, E Masliah, RB Effros, MF Chesselet
Experimental Neurology 2012
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?
CM Tomé, T Tyson, NL Rey, S Grathwohl, M Britschgi, P Brundin
Molecular Neurobiology 2012
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice
MF Chesselet, F Richter, C Zhu, I Magen, MB Watson, SR Subramaniam
Neurotherapeutics 2012
Innate inflammation in Parkinson's disease
VH Perry
Cold Spring Harbor Perspectives in Medicine 2012
Mechanisms of Altered Redox Regulation in Neurodegenerative Diseases—Focus on S-Glutathionylation
EA Liedhegner, XH Gao, JJ Mieyal
Antioxidants & Redox Signaling 2012
Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration
JR Sundaram, ES Chan, CP Poore, TK Pareek, WF Cheong, G Shui, N Tang, CM Low, MR Wenk, S Kesavapany
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?
Carta AR, Pisanu A
Neurotoxicity Research 2012
Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons
A Machado, AJ Herrera, JL Venero, M Santiago, RM de Pablos, RF Villarán, AM Espinosa-Oliva, S Argüelles, M Sarmiento, MJ Delgado-Cortés, R Mauriño, J Cano
ISRN Neurology 2011
Inflammation in the early stages of neurodegenerative pathology
PJ Khandelwal, AM Herman, CE Moussa
Journal of Neuroimmunology 2011
Parkinson's Disease and Systemic Inflammation
CC Ferrari, R Tarelli
Parkinson's Disease 2011
Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence
A Machado, AJ Herrera, JL Venero, M Santiago, RM de Pablos, RF Villarán, AM Espinosa-Oliva, S Argüelles, M Sarmiento, MJ Delgado-Cortés, R Mauriño, J Cano
Parkinson's Disease 2011
The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease
KU Tufekci, S Genc, K Genc
Parkinson's Disease 2011
Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?
AR Carta, A Pisanu, E Carboni
Parkinson's Disease 2011
Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease
D Litteljohn, E Mangano, M Clarke, J Bobyn, K Moloney, S Hayley
Parkinson's Disease 2011
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
L Fellner, KA Jellinger, GK Wenning, N Stefanova
Acta Neuropathologica 2011
Involvement of the Fcγ Receptor in a Chronic N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Dopaminergic Loss*
A Lira, J Kulczycki, R Slack, H Anisman, DS Park
The Journal of biological chemistry 2011
BCG Vaccine-Induced Neuroprotection in a Mouse Model of Parkinson's Disease
J Yong, G Lacan, H Dang, T Hsieh, B Middleton, C Wasserfall, J Tian, WP Melega, DL Kaufman
PloS one 2011
Axonal Damage in Multiple Sclerosis
JD Haines, M Inglese, P Casaccia
The Mount Sinai journal of medicine, New York 2011
Regulation by Glycogen Synthase Kinase-3 of Inflammation and T Cells in CNS Diseases
E Beurel
Frontiers in molecular neuroscience 2011
Immunolocalization of Influenza A Virus and Markers of Inflammation in the Human Parkinson's Disease Brain
TT Rohn, LW Catlin
PloS one 2011
An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity
A Patel, GV Toia, K Colletta, BD Bradaric, PM Carvey, B Hendey
Experimental Neurology 2011
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
C Barcia, CM Ros, V Annese, A Gómez, F Ros-Bernal, D Aguado-Yera, ME Martínez-Pagán, V Pablos, E Fernandez-Villalba, MT Herrero
Cell Death and Disease 2011
Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
J Thévenet, RP Gobert, RH van Huijsduijnen, C Wiessner, YJ Sagot
PloS one 2011
Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection
S Stemberger, A Jamnig, N Stefanova, G Lepperdinger, M Reindl, GK Wenning
PloS one 2011
Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
M Hakimi, T Selvanantham, E Swinton, RF Padmore, Y Tong, G Kabbach, K Venderova, SE Girardin, DE Bulman, CR Scherzer, MJ LaVoie, D Gris, DS Park, JB Angel, J Shen, DJ Philpott, MG Schlossmacher
Journal of Neural Transmission 2011
The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
J Drouin-Ouellet, C Gibrat, M Bousquet, F Calon, J Kriz, F Cicchetti
Journal of Neuroinflammation 2011
Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease
MT Armentero, A Pinna, S Ferré, JL Lanciego, CE Müller, R Franco
Pharmacology & Therapeutics 2011
Pathways towards an effective immunotherapy for Parkinson's disease
JA Hutter-Saunders, RL Mosley, HE Gendelman
Expert Review of Neurotherapeutics 2011
The executioners sing a new song: killer caspases activate microglia
JL Venero, MA Burguillos, P Brundin, B Joseph
Cell Death and Differentiation 2011
Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy
BD Bradaric, A Patel, JA Schneider, PM Carvey, B Hendey
Journal of Neural Transmission - Parkinson's Disease and Dementia Section 2011
FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice
WB 2nd, A Manaenko, T Lekic, Y Hasegawa, R Ostrowski, J Tang, JH Zhang
Acta neurochirurgica. Supplement 2011
Activated immune cells in Parkinson's disease.
Cao JJ, Li KS, Shen YQ
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2011
Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in primary midbrain cultures.
Wang F, Zhai H, Huang L, Li H, Xu Y, Qiao X, Sun S, Wu Y
Journal of molecular neuroscience : MN 2011
Kynurenines in Parkinson's disease: therapeutic perspectives.
Zádori D, Klivényi P, Toldi J, Fülöp F, Vécsei L
Journal of neural transmission (Vienna, Austria : 1996) 2011
Trafficking of immune cells in the central nervous system
Emma H. Wilson, Wolfgang Weninger, Chris Hunter
Journal of Clinical Investigation 2010
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
V Sanchez-Guajardo, F Febbraro, D Kirik, M Romero-Ramos
PloS one 2010
Inflammation in neurodegenerative diseases
S Amor, F Puentes, D Baker, P der Valk
Immunology 2010
Mechanisms underlying inflammation in neurodegeneration
CK Glass, K Saijo, B Winner, MC Marchetto, FH Gage
Cell 2010
T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
SH Appel, DR Beers, JS Henkel
Trends in Immunology 2010
Basic mechanisms of neurodegeneration: a critical update
KA Jellinger
Journal of Cellular and Molecular Medicine 2010
Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
S Cao, S Theodore, DG Standaert
Molecular Neurodegeneration 2010
Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy
L Qian, PM Flood, JS Hong
Journal of Neural Transmission 2010
POTENTIAL FUTURE NEUROPROTECTIVE THERAPIES FOR NEURODEGENERATIVE DISORDERS AND STROKE
R Tarawneh, JE Galvin
Clinics in Geriatric Medicine 2010
Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats
Z Yu, X Xu, Z Xiang, J Zhou, Z Zhang, C Hu, C He
PloS one 2010
Expression and regulation in the brain of the chemokine CCL27 gene locus
C Gunsolly, JD Nicholson, SJ Listwak, D Ledee, P Zelenka, D Verthelyi, S Chapoval, A Keegan, LH Tonelli
Journal of Neuroimmunology 2010
Pharmacological Therapy in Parkinson's Disease: Focus on Neuroprotection: Neuroprotection in Parkinson's Disease
ZT Kincses, L Vecsei
CNS Neuroscience & Therapeutics 2010
Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.
Davies NW, Guillemin G, Brew BJ
International journal of tryptophan research : IJTR 2010
Nitrated Alpha Synuclein Induced Alterations in Microglial Immunity is Regulated by CD4+ T Cell Subsets1
AD Reynolds, DK Stone, RL Mosley, HE Gendelman
Journal of immunology (Baltimore, Md. : 1950) 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
CD 4+ T cells in the pathobiology of neurodegenerative disorders
X Huang, AD Reynolds, RL Mosley, HE Gendelman
Journal of Neuroimmunology 2009
Targeting neural precursors in the adult brain rescues injured dopamine neurons
A Androutsellis-Theotokis, MA Rueger, DM Park, H Mkhikian, E Korb, SW Poser, S Walbridge, J Munasinghe, AP Koretsky, RR Lonser, RD McKay
Proceedings of the National Academy of Sciences 2009
CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?
K Rezai-Zadeh, D Gate, T Town
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009
Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease
A Ghosh, A Roy, J Matras, S Brahmachari, HE Gendelman, K Pahan
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Immune activation in brain aging and neurodegeneration: too much or too little?
KM Lucin, T Wyss-Coray
Neuron 2009
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
H Ilieva, M Polymenidou, DW Cleveland
The Journal of Cell Biology 2009
Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice
T Ishikawa, H Yamada, A Oyamada, F Goshima, Y Nishiyama, Y Yoshikai
Journal of virology 2009
Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain
SH Choi, S Aid, U Choi, F Bosetti
The Pharmacogenomics Journal 2009
The Blood Brain Barrier in Neurodegenerative Disease: A Rhetorical Perspective
PM Carvey, B Hendey, AJ Monahan
Journal of Neurochemistry 2009
Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells
AD Reynolds, DK Stone, RL Mosley, HE Gendelman
Journal of Proteome Research 2009
Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival
AD Kraft, CA McPherson, GJ Harry
NeuroToxicology 2009
Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention
MG Tansey, MS Goldberg
Neurobiology of Disease 2009
Neuroinflammation in Parkinson's disease
JK Lee, T Tran, MG Tansey
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009
Recent advances in our understanding of neurodegeneration
KA Jellinger
Journal of Neural Transmission 2009
CD4+ T cells mediate cytotoxicity in neurodegenerative diseases
Stanley H. Appel
Journal of Clinical Investigation 2008

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