Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the adaptive immune system in PD remains enigmatic. Here we showed that CD8+ and CD4+ T cells but not B cells had invaded the brain in both postmortem human PD specimens and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD during the course of neuronal degeneration. We further demonstrated that MPTP-induced dopaminergic cell death was markedly attenuated in the absence of mature T lymphocytes in 2 different immunodeficient mouse strains (Rag1–/– and Tcrb–/– mice). Importantly, similar attenuation of MPTP-induced dopaminergic cell death was seen in mice lacking CD4 as well as in Rag1–/– mice reconstituted with FasL-deficient splenocytes. However, mice lacking CD8 and Rag1–/– mice reconstituted with IFN-γ–deficient splenocytes were not protected. These data indicate that T cell–mediated dopaminergic toxicity is almost exclusively arbitrated by CD4+ T cells and requires the expression of FasL but not IFNγ. Further, our data may provide a rationale for targeting the adaptive arm of the immune system as a therapeutic strategy in PD.
Vanessa Brochard, Béhazine Combadière, Annick Prigent, Yasmina Laouar, Aline Perrin, Virginie Beray-Berthat, Olivia Bonduelle, Daniel Alvarez-Fischer, Jacques Callebert, Jean-Marie Launay, Charles Duyckaerts, Richard A. Flavell, Etienne C. Hirsch, Stéphane Hunot
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Xiao Y, Wei Q, Ou R, Yang T, Jiang Q, Hou Y, Zhang L, Liu K, Wang S, Lin J, Zhao B, Song W, Chen X, Wu Y, Li C, Shang H |
Journal of Neurology | 2023 |
Ovalbumin-specific CD4+ and CD8+ T cells contribute to different susceptibility for Theiler’s murine encephalomyelitis virus persistence
Wannemacher R, Reiß A, Rohn K, Lühder F, Flügel A, Baumgärtner W, Hülskötter K |
Frontiers in immunology | 2023 |
The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease
de Rus Jacquet A, Alpaugh M, Denis HL, Tancredi JL, Boutin M, Decaestecker J, Beauparlant C, Herrmann L, Saint-Pierre M, Parent M, Droit A, Breton S, Cicchetti F |
Nature Communications | 2023 |
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Schonhoff AM, Figge DA, Williams GP, Jurkuvenaite A, Gallups NJ, Childers GM, Webster JM, Standaert DG, Goldman JE, Harms AS |
Nature Communications | 2023 |
CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson's disease.
Frosch M, Amann L, Prinz M |
Nature Communications | 2023 |
GATA3 as a Blood-Based RNA Biomarker for Idiopathic Parkinson’s Disease
Acharya S, Lumley AI, Zhang L, Vausort M, Devaux Y |
International journal of molecular sciences | 2023 |
Peripheral MC1R activation modulates immune responses and is neuroprotective in a mouse model of Parkinson’s disease
Srivastava P, Nishiyama S, Lin SH, Srivastava A, Su C, Peng W, Levy M, Schwarzschild M, Xu Y, Chen X |
Research square | 2023 |
Exosomes derived from human umbilical cord mesenchymal stem cells alleviate Parkinson’s disease and neuronal damage through inhibition of microglia
Zhang ZX, Zhou YJ, Gu P, Zhao W, Chen HX, Wu RY, Zhou LY, Cui QZ, Sun SK, Zhang LQ, Zhang K, Xu HJ, Chai XQ, An SJ |
Neural Regeneration Research | 2023 |
Deep brain stimulation improves central nervous system inflammation in Parkinson's disease: Evidence and perspectives.
Chang L, Dong WW, Luo B, Qiu C, Lu Y, Lin XJ, Zhang WB |
CNS Neuroscience & Therapeutics | 2023 |
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Jacques CED, Guerreiro G, Lopes FF, de Souza CFM, Giugliani R, Vargas CR |
Cell Biochemistry and Biophysics | 2023 |
Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats
Lamberty BG, Estrella LD, Mattingly JE, Emanuel K, Trease A, Totusek S, Sheldon L, George JW, Almikhlafi MA, Farmer T, Stauch KL |
2023 | |
Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics
Iyaswamy A, Lu K, Guan XJ, Kan Y, Su C, Liu J, Jaganathan R, Vasudevan K, Paul J, Thakur A, Li M |
Biomedicines | 2023 |
Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases
Abbaoui A, Fatoba O, Yamashita T |
Frontiers in cellular neuroscience | 2023 |
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Hobson BD, Stanley AT, De Los Santos MB, Culbertson B, Mosharov EV, Sims PA, Sulzer D |
Brain, Behavior, and Immunity | 2023 |
The Molecular Mechanisms of the Relationship between Insulin Resistance and Parkinson's Disease Pathogenesis.
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Nutrients | 2023 |
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Spanos F, Deleidi M |
FEBS Open Bio | 2023 |
T Lymphocytes and Their Potential Role in Dementia with Lewy Bodies
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Cells | 2023 |
Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?
Furgiuele A, Pereira FC, Martini S, Marino F, Cosentino M |
IBMS BoneKEy | 2023 |
Alpha-Synuclein-Specific Regulatory T Cells Ameliorate Parkinson’s Disease Progression in Mice
Park SY, Yang H, Kim S, Yang J, Go H, Bae H |
International journal of molecular sciences | 2023 |
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Abdelmoaty MM, Lu E, Kadry R, Foster EG, Bhattarai S, Mosley RL, Gendelman HE |
Cell & Bioscience | 2023 |
CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease
Zhao J, An K, Mao Z, Qu Y, Wang D, Li J, Min Z, Xue Z |
Frontiers in aging neuroscience | 2023 |
Oral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice
Bai XB, Xu S, Zhou LJ, Meng XQ, Li YL, Chen YL, Jiang YH, Lin WZ, Chen BY, Du LJ, Tian GC, Liu Y, Duan SZ, Zhu YQ |
Microbiome | 2023 |
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Bérard M, Martínez-Drudis L, Sheta R, El-Agnaf OM, Oueslati A |
Molecular Neurodegeneration | 2023 |
CD8+ T cells in brain injury and neurodegeneration
Zhang Z, Duan Z, Cui Y |
Frontiers in cellular neuroscience | 2023 |
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Dzamko N |
2023 | |
Microglial Inflammatory Responses to SARS-CoV-2 Infection: A Comprehensive Review.
Dey R, Bishayi B |
Cellular and Molecular Neurobiology | 2023 |
Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson’s Disease
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International journal of molecular sciences | 2023 |
Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson’s Disease
Srivastava P, Nishiyama S, Zhou F, Lin SH, Srivastava A, Su C, Xu Y, Peng W, Levy M, Schwarzschild M, Chen X |
Journal of Neuroimmune Pharmacology | 2023 |
Detecting ferroptosis and immune infiltration profiles in multiple system atrophy using postmortem brain tissue
Chen L, Mao L, Lu H, Liu P |
Frontiers in neuroscience | 2023 |
Extracellular Vesicles: The Invisible Heroes and Villains of COVID-19 Central Neuropathology.
Chang H, Chen E, Hu Y, Wu L, Deng L, Ye-Lehmann S, Mao X, Zhu T, Liu J, Chen C |
2023 | |
Novel therapeutic approaches to target neurodegeneration
de la Fuente AG, Pelucchi S, Mertens J, Di Luca M, Mauceri D, Marcello E |
British Journal of Pharmacology | 2023 |
Interaction of an α-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
Garretti F, Monahan C, Sloan N, Bergen J, Shahriar S, Kim SW, Sette A, Cutforth T, Kanter E, Agalliu D, Sulzer D |
Neuron | 2023 |
Brain and Systemic Inflammation in De Novo Parkinson's Disease
Yacoubian TA, Fang YD, Gerstenecker A, Amara A, Stover N, Ruffrage L, Collette C, Kennedy R, Zhang Y, Hong H, Qin H, McConathy J, Benveniste EN, Standaert DG |
Movement Disorders | 2023 |
Mutant LRRK2 in lymphocytes regulates neurodegeneration via IL-6 in an inflammatory model of Parkinson’s disease
E Kozina, M Byrne, R Smeyne |
npj Parkinson's Disease | 2022 |
Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
C Rickenbach, C Gericke |
Frontiers in neuroscience | 2022 |
The Emerging Role of Central and Peripheral Immune Systems in Neurodegenerative Diseases
X Zang, S Chen, J Zhu, J Ma, Y Zhai |
Frontiers in aging neuroscience | 2022 |
Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit
G Paul, O Elabi |
Frontiers in aging neuroscience | 2022 |
Emerging targets signaling for inflammation in Parkinson’s disease drug discovery
R Khairnar, N Parihar, K Prabhavalkar, L Bhatt |
Metabolic Brain Disease | 2022 |
Noninvasive Imaging of CD4+ T Cells in Humanized Mice
V Nagle, C Hertz, K Henry, M Graham, C Campos, N Pillarsetty, A Schietinger, I Mellinghoff, J Lewis |
Molecular cancer therapeutics | 2022 |
Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
T Lai, Y Kim, H Ma, Y Kim |
Journal of Movement Disorders | 2022 |
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Tian J, Dai SB, Jiang SS, Yang WY, Yan YQ, Lin ZH, Dong JX, Liu Y, Zheng R, Chen Y, Zhang BR, Pu JL |
npj Parkinson's Disease | 2022 |
Peripheral Immune Cell Numbers and C-Reactive Protein in Parkinson's Disease: Results from a Population-Based Study.
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Journal of Parkinson's disease | 2022 |
Inflammation and immune dysfunction in Parkinson disease.
Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V |
Nature reviews. Immunology | 2022 |
Global Characterization of Peripheral B Cells in Parkinson's Disease by Single-Cell RNA and BCR Sequencing.
Wang P, Luo M, Zhou W, Jin X, Xu Z, Yan S, Li Y, Xu C, Cheng R, Huang Y, Lin X, Yao L, Nie H, Jiang Q |
Frontiers in immunology | 2022 |
Changes of T lymphocyte subpopulations and their roles in predicting the risk of Parkinson's disease.
He Y, Peng K, Li R, Zhang Z, Pan L, Zhang T, Lin A, Hong R, Nie Z, Guan Q, Jin L |
Journal of Neurology | 2022 |
DAT and TH expression marks human Parkinson's disease in peripheral immune cells.
Gopinath A, Mackie P, Hashimi B, Buchanan AM, Smith AR, Bouchard R, Shaw G, Badov M, Saadatpour L, Gittis A, Ramirez-Zamora A, Okun MS, Streit WJ, Hashemi P, Khoshbouei H |
npj Parkinson's Disease | 2022 |
The immunology of Parkinson's disease.
Zhu B, Yin D, Zhao H, Zhang L |
Seminars in Immunopathology | 2022 |
A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease.
Salemi M, Lanza G, Mogavero MP, Cosentino FII, Borgione E, Iorio R, Ventola GM, Marchese G, Salluzzo MG, Ravo M, Ferri R |
International journal of molecular sciences | 2022 |
Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells
Ng L, Wang X, Yang C, Su C, Li M, Cheung AK |
Frontiers in immunology | 2022 |
Peripheral inflammatory cytokines and motor symptoms in persons with Parkinson's disease
Diaz K, Kohut ML, Russell DW, Stegemöller EL |
2022 | |
The blood-brain barrier in aging and neurodegeneration
Knox EG, Aburto MR, Clarke G, Cryan JF, O\u2019Driscoll CM |
Molecular Psychiatry | 2022 |
Neuroinflammation in Parkinson’s Disease – Putative Pathomechanisms and Targets for Disease-Modification
Grotemeyer A, McFleder RL, Wu J, Wischhusen J, Ip CW |
Frontiers in immunology | 2022 |
Age-Related Midbrain Inflammation and Senescence in Parkinson’s Disease
Russo T, Riessland M |
Frontiers in aging neuroscience | 2022 |
Integrating Primary Astrocytes in a Microfluidic Model of the Blood-Brain Barrier.
Lauranzano E, Rasile M, Matteoli M |
Methods in molecular biology (Clifton, N.J.) | 2022 |
Prognostic significance of SNCA and its methylation in bladder cancer
Wu Z, Xia C, Zhang C, Yang D, Ma K |
BMC Cancer | 2022 |
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
Heidari A, Yazdanpanah N, Rezaei N |
Journal of Neuroinflammation | 2022 |
Challenges of repurposing tetracyclines for the treatment of Alzheimer's and Parkinson's disease.
Markulin I, Matasin M, Turk VE, Salković-Petrisic M |
Journal of neural transmission (Vienna, Austria : 1996) | 2022 |
Survival motor neuron protein deficiency alters microglia reactivity.
Khayrullina G, Alipio-Gloria ZA, Deguise MO, Gagnon S, Chehade L, Stinson M, Belous N, Bergman EM, Lischka FW, Rotty J, Dalgard CL, Kothary R, Johnson KA, Burnett BG |
Glia | 2022 |
α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease.
Liu Z, Chan RB, Cai Z, Liu X, Wu Y, Yu Z, Feng T, Yang Y, Zhang J |
Journal of Neuroinflammation | 2022 |
The aging immune system in Alzheimer's and Parkinson's diseases.
Heavener KS, Bradshaw EM |
Seminars in Immunopathology | 2022 |
Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson’s Disease Research and Therapeutic Development
McComish SF, MacMahon Copas AN, Caldwell MA |
Frontiers in neuroscience | 2022 |
The Pathological Mechanism Between the Intestine and Brain in the Early Stage of Parkinson's Disease
Yang R, Gao G, Yang H |
Frontiers in aging neuroscience | 2022 |
Emerging Roles of T Helper Cells in Non-Infectious Neuroinflammation: Savior or Sinner
Liu W, Fan M, Lu W, Zhu W, Meng L, Lu S |
Frontiers in immunology | 2022 |
Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review
Fathi M, Vakili K, Yaghoobpoor S, Qadirifard MS, Kosari M, Naghsh N, Asgari taei A, Klegeris A, Dehghani M, Bahrami A, Taheri H, Mohamadkhani A, Hajibeygi R, Rezaei Tavirani M, Sayehmiri F |
Frontiers in aging neuroscience | 2022 |
Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease.
Garcia P, Jürgens-Wemheuer W, Uriarte Huarte O, Michelucci A, Masuch A, Brioschi S, Weihofen A, Koncina E, Coowar D, Heurtaux T, Glaab E, Balling R, Sousa C, Kaoma T, Nicot N, Pfander T, Schulz-Schaeffer W, Allouche A, Fischer N, Biber K, Kleine-Borgmann F, Mittelbronn M, Ostaszewski M, Schmit KJ, Buttini M |
Glia | 2022 |
Monocyte biomarkers define sargramostim treatment outcomes for Parkinson's disease.
Abdelmoaty MM, Machhi J, Yeapuri P, Shahjin F, Kumar V, Olson KE, Mosley RL, Gendelman HE |
Clinical and Translational Medicine | 2022 |
Iron, Neuroinflammation and Neurodegeneration.
Ward RJ, Dexter DT, Crichton RR |
International journal of molecular sciences | 2022 |
Identification of Immune-Related Hub Genes in Parkinson's Disease.
Chen L, Wang Y, Huang J, Hu B, Huang W |
Frontiers in Genetics | 2022 |
Research progress in the early diagnosis of Parkinson's disease.
Xie L, Hu L |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2022 |
Neuronal Presentation of Antigen and Its Possible Role in Parkinson’s Disease
Hobson BD, Sulzer D |
Journal of Parkinson's disease | 2022 |
Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study
Liu SY, Qiao HW, Song TB, Liu XL, Yao YX, Zhao CS, Barret O, Xu SL, Cai YN, Tamagnan GD, Sossi V, Lu J, Chan P |
Journal of Neuroinflammation | 2022 |
Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases.
Boyd RJ, Avramopoulos D, Jantzie LL, McCallion AS |
Journal of Neuroinflammation | 2022 |
Post-COVID-19 Parkinsonism and Parkinson's Disease Pathogenesis: The Exosomal Cargo Hypothesis.
Mysiris DS, Vavougios GD, Karamichali E, Papoutsopoulou S, Stavrou VT, Papayianni E, Boutlas S, Mavridis T, Foka P, Zarogiannis SG, Gourgoulianis K, Xiromerisiou G |
International journal of molecular sciences | 2022 |
T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV.
Williams DW, Flores BR, Xu Y, Wang Y, Yu D, Peters BA, Adedimeji A, Wilson TE, Merenstein D, Tien PC, Cohen MH, Weber KM, Adimora AA, Ofotokun I, Fischl M, Turan J, Turan B, Laumet G, Landay AL, Dastgheyb RM, Gange SJ, Weiser SD, Rubin LH |
2022 | |
The role of antiviral CD8+ T cells in cognitive impairment.
Reagin KL, Funk KE |
Current Opinion in Neurobiology | 2022 |
Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities
Araújo B, Caridade-Silva R, Soares-Guedes C, Martins-Macedo J, Gomes ED, Monteiro S, Teixeira FG |
Cells | 2022 |
Genotype–phenotype correlation of T-cell subtypes reveals senescent and cytotoxic genes in Alzheimer’s disease
Dressman D, Buttrick T, Cimpean M, Bennett D, Menon V, Bradshaw EM, Vardarajan B, Elyaman W |
Human Molecular Genetics | 2022 |
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
DeMaio A, Mehrotra S, Sambamurti K, Husain S |
Journal of Neuroinflammation | 2022 |
Single-cell RNA sequencing of CSF reveals neuroprotective RAC1+ NK cells in Parkinson’s disease
Guan Q, Liu W, Mu K, Hu Q, Xie J, Cheng L, Wang X |
Frontiers in immunology | 2022 |
Lymphocyte Count and Neutrophil-to-Lymphocyte Ratio Are Associated with Mild Cognitive Impairment in Parkinson’s Disease: A Single-Center Longitudinal Study
Contaldi E, Magistrelli L, Cosentino M, Marino F, Comi C |
Journal of Clinical Medicine | 2022 |
T Lymphocytes in Parkinson's Disease.
Contaldi E, Magistrelli L, Comi C |
Journal of Parkinson's disease | 2022 |
Age-Related Adaptive Immune Changes in Parkinson's Disease.
Kouli A, Williams-Gray CH |
Journal of Parkinson's disease | 2022 |
Inflammatory Animal Models of Parkinson's Disease.
García-Revilla J, Herrera AJ, de Pablos RM, Venero JL |
Journal of Parkinson's disease | 2022 |
Neuroinflammation and Immune Changes in Prodromal Parkinson's Disease and Other Synucleinopathies.
Terkelsen MH, Klaestrup IH, Hvingelby V, Lauritsen J, Pavese N, Romero-Ramos M |
Journal of Parkinson's disease | 2022 |
Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease.
Williams GP, Schonhoff AM, Sette A, Lindestam Arlehamn CS |
Journal of Parkinson's disease | 2022 |
The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease.
Alosaimi F, Boonstra JT, Tan S, Temel Y, Jahanshahi A |
Frontiers in neuroscience | 2022 |
Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition
Princiotta Cariddi L, Mauri M, Cosentino M, Versino M, Marino F |
International journal of molecular sciences | 2022 |
Natural product-based pharmacological studies for neurological disorders
Puri V, Kanojia N, Sharma A, Huanbutta K, Dheer D, Sangnim T |
Frontiers in pharmacology | 2022 |
WDR43 is a potential diagnostic biomarker and therapeutic target for osteoarthritis complicated with Parkinson’s disease
Heng H, Liu J, Hu M, Li D, Su W, Li J |
Frontiers in cellular neuroscience | 2022 |
Dopaminergic Signalling Enhances IL-2 Production and Strengthens Anti-Tumour Response Exerted by Cytotoxic T Lymphocytes in a Melanoma Mouse Model
Chovar-Vera O, López E, Gálvez-Cancino F, Prado C, Franz D, Figueroa DA, Espinoza A, Figueroa C, Lladser A, Pacheco R |
Cells | 2022 |
Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation
Silva DF, Empadinhas N, Cardoso SM, Esteves AR |
Antioxidants | 2022 |
Calpain activation and progression of inflammatory cycles in Parkinson’s disease
Gao A, McCoy HM, Zaman V, Shields DC, Banik NL, Haque A |
2022 | |
How the immune system shapes neurodegenerative diseases.
Mason HD, McGavern DB |
Trends in Neurosciences | 2022 |
Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson's Disease.
Al-Nusaif M, Lin Y, Li T, Cheng C, Le W |
International journal of molecular sciences | 2022 |
Mechanisms of Autoimmune Cell in DA Neuron Apoptosis of Parkinson's Disease: Recent Advancement
Zheng Z, Zhang S, Zhang H, Gao Z, Wang X, Liu X, Xue C, Yao L, Lu G |
Oxidative medicine and cellular longevity | 2022 |
High resolution 16S rRNA gene Next Generation Sequencing study of brain areas associated with Alzheimer’s and Parkinson’s disease
Emery DC, Davies M, Cerajewska TL, Taylor J, Hazell M, Paterson A, Allen-Birt SJ, West NX |
Frontiers in aging neuroscience | 2022 |
Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson's disease mice.
Badr M, McFleder RL, Wu J, Knorr S, Koprich JB, Hünig T, Brotchie JM, Volkmann J, Lutz MB, Ip CW |
Journal of Neuroinflammation | 2022 |
An opinion on the debatable function of brain resident immune protein, T-cell receptor beta subunit in the central nervous system
Komal P, Manjari SK, Nashmi R |
2022 | |
Neuro faces of beneficial T cells: essential in brain, impaired in aging and neurological diseases, and activated functionally by neurotransmitters and neuropeptides
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Neural Regeneration Research | 2022 |
Genome integrity and inflammation in the nervous system.
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DNA repair | 2022 |
Unaltered T cell responses to common antigens in individuals with Parkinson’s disease
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Journal of the Neurological Sciences | 2022 |
Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease
Basurco L, Abellanas MA, Ayerra L, Conde E, Vinueza\u2010Gavilanes R, Luquin E, Vales A, Vilas A, Martin\u2010Uriz PS, Tamayo I, Alonso MM, Hernaez M, Gonzalez\u2010Aseguinolaza G, Clavero P, Mengual E, Arrasate M, Hervás\u2010Stubbs S, Aymerich MS |
Glia | 2022 |
Glia as antigen-presenting cells in the central nervous system
Sutter PA, Crocker SJ |
Current Opinion in Neurobiology | 2022 |
T cells, α-synuclein and Parkinson disease.
Garretti F, Monahan C, Sette A, Agalliu D, Sulzer D |
Handbook of Clinical Neurology | 2022 |
Neuroinflammation: 2022 update
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Free neuropathology | 2022 |
Development of an extended half-life GM-CSF fusion protein for Parkinson’s disease
Yeapuri P, Olson KE, Lu Y, Abdelmoaty MM, Namminga KL, Markovic M, Machhi J, Mosley RL, Gendelman HE |
Journal of Controlled Release | 2022 |
The complex role of inflammation and gliotransmitters in Parkinson's disease.
Gopinath A, Mackie PM, Phan LT, Tansey MG, Khoshbouei H |
Neurobiology of Disease | 2022 |
Gut microbiome and Parkinson's disease: Perspective on pathogenesis and treatment
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Journal of Advanced Research | 2022 |
Regulatory T Cell Therapeutics for Neuroinflammatory Disorders.
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Critical reviews in immunology | 2022 |
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology
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Acta Neuropathologica Communications | 2021 |
Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease
Z Yan, W Yang, H Wei, MN Dean, DG Standaert, GR Cutter, EN Benveniste, H Qin |
Neurology: Neuroimmunology & Neuroinflammation | 2021 |
Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson’s disease patients
Z Karaaslan, ÖT Kahraman, E Şanlı, HA Ergen, C Ulusoy, B Bilgiç, V Yılmaz, E Tüzün, HA Hanağası, Cİ Küçükali |
Scientific Reports | 2021 |
Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy
KM Delgado-Minjares, D Martinez-Fong, IA Martínez-Dávila, C Bañuelos, ME Gutierrez-Castillo, VM Blanco-Alvarez, MC Cardenas-Aguayo, J Luna-Muñoz, M Pacheco-Herrero, LO Soto-Rojas |
International journal of molecular sciences | 2021 |
Cellular and molecular pathophysiology in the progression of Parkinson’s disease
V Zaman, DC Shields, R Shams, KP Drasites, D Matzelle, A Haque, NL Banik |
Metabolic Brain Disease | 2021 |
Emerging targets for the diagnosis of Parkinson’s disease: examination of systemic biomarkers
L Cheslow, AE Snook, SA Waldman |
Biomarkers in Medicine | 2021 |
The Positive Role and Mechanism of Herbal Medicine in Parkinson’s Disease
R Yin, J Xue, Y Tan, C Fang, C Hu, Q Yang, X Mei, D Qi, S Hrelia |
Oxidative Medicine & Cellular Longevity | 2021 |
Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease
A Drobny, PA Ngo, MF Neurath, F Zunke, R López-Posadas |
Frontiers in Medicine | 2021 |
Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration
M Dolatshahi, M Sabahi, MH Aarabi |
Molecular Neurobiology | 2021 |
Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System
DC Ivan, S Walthert, K Berve, J Steudler, G Locatelli |
Frontiers in immunology | 2021 |
Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk
AP Passaro, AL Lebos, Y Yao, SL Stice |
Frontiers in immunology | 2021 |
Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model
S Lee, YJ Suh, S Yang, DG Hong, A Ishigami, H Kim, JS Hur, SC Chang, J Lee |
International journal of molecular sciences | 2021 |
Bilirubin: A Promising Therapy for Parkinson’s Disease
S Jayanti, R Moretti, C Tiribelli, S Gazzin |
International journal of molecular sciences | 2021 |
Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity
E Gregersen, C Betzer, WS Kim, G Kovacs, L Reimer, GM Halliday, S Thiel, PH Jensen |
Journal of Neuroinflammation | 2021 |
T lymphocyte senescence is attenuated in Parkinson’s disease
A Kouli, M Jensen, V Papastavrou, KM Scott, C Kolenda, C Parker, IH Solim, M Camacho, C Martin-Ruiz, CH Williams-Gray |
Journal of Neuroinflammation | 2021 |
Cholinergic Modulation of the Immune System in Neuroinflammatory Diseases
M Reale, E Costantini |
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The Contribution of Microglia to Neuroinflammation in Parkinson’s Disease
K Badanjak, S Fixemer, S Smajić, A Skupin, A Grünewald |
International journal of molecular sciences | 2021 |
The Intersection of Parkinson’s Disease, Viral Infections, and COVID-19
B Rosen, A Kurtishi, GR Vazquez-Jimenez, SG Møller |
Molecular Neurobiology | 2021 |
Potential Effects of Leukotriene Receptor Antagonist Montelukast in Treatment of Neuroinflammation in Parkinson’s Disease
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International journal of molecular sciences | 2021 |
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
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Frontiers in neuroscience | 2021 |
Neuroimmune multi-hit perspective of coronaviral infection
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Journal of Neuroinflammation | 2021 |
The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?
AN Copas, SF McComish, JM Fletcher, MA Caldwell |
Frontiers in neurology | 2021 |
B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights
JJ Ahn, M Abu-Rub, RH Miller |
Cells | 2021 |
Content of Peripheral Blood T- and B-Cell Subpopulations in Transgenic A53T Mice of Different Age (A Model of Parkinson’s Disease)
GV Idova, EL Alperina, MM Gevorgyan, MA Tikhonova, SY Zhanaeva |
Bulletin of Experimental Biology and Medicine | 2021 |
Highlighting Immune System and Stress in Major Depressive Disorder, Parkinson’s, and Alzheimer’s Diseases, with a Connection with Serotonin
AS Correia, A Cardoso, N Vale |
International journal of molecular sciences | 2021 |
Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson’s disease
EJ Shin, JH Jeong, Y Hwang, N Sharma, DK Dang, BT Nguyen, SY Nah, CG Jang, G Bing, T Nabeshima, HC Kim |
Archives of Pharmacal Research | 2021 |
High Inflammatory Tendency Induced by Malignant Stimulation Through Imbalance of CD28 and CTLA-4/PD-1 Contributes to Dopamine Neuron Injury
L Dong, YM Zheng, XG Luo, ZY He |
Journal of inflammation research | 2021 |
Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction
A Mancini, V Ghiglieri, L Parnetti, P Calabresi, MD Filippo |
Frontiers in immunology | 2021 |
Periphery and brain, innate and adaptive immunity in Parkinson’s disease
AS Harms, SA Ferreira, M Romero-Ramos |
Acta Neuropathologica | 2021 |
Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?
LY Tan, XY Yeo, HG Bae, DP Lee, RC Ho, JE Kim, DG Jo, S Jung |
Life Sciences | 2021 |
Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease
AF Magnusen, SL Hatton, R Rani, MK Pandey |
Frontiers in neurology | 2021 |
Circadian Clock Regulates Inflammation and the Development of Neurodegeneration
XL Wang, L Li |
Frontiers in Cellular and Infection Microbiology | 2021 |
Paracellular and Transcellular Leukocytes Diapedesis Are Divergent but Interconnected Evolutionary Events
ME Mickael, N Kubick, P Klimovich, PH Flournoy, I Bieńkowska, M Sacharczuk |
Genes & development | 2021 |
Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease
R Su, T Zhou |
Frontiers in aging neuroscience | 2021 |
Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
P Wang, L Yao, M Luo, W Zhou, X Jin, Z Xu, S Yan, Y Li, C Xu, R Cheng, Y Huang, X Lin, K Ma, H Cao, H Liu, G Xue, F Han, H Nie, Q Jiang |
Cell Discovery | 2021 |
The cell biology of Parkinson’s disease
N Panicker, P Ge, VL Dawson, TM Dawson |
The Journal of Cell Biology | 2021 |
Abnormal B-Cell and Tfh-Cell Profiles in Patients With Parkinson Disease: A Cross-sectional Study
R Li, TF Tropea, LR Baratta, L Zuroff, ME Diaz-Ortiz, B Zhang, K Shinoda, A Rezk, RN Alcalay, A Chen-Plotkin, A Bar-Or |
Neurology: Neuroimmunology & Neuroinflammation | 2021 |
Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson’s disease
AD Thome, F Atassi, J Wang, A Faridar, W Zhao, JR Thonhoff, DR Beers, EC Lai, SH Appel |
npj Parkinson's Disease | 2021 |
Immune cell compartmentalization for brain surveillance and protection
T Croese, G Castellani, M Schwartz |
Nature Immunology | 2021 |
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
OC Kwon, JJ Song, Y Yang, SH Kim, JY Kim, MJ Seok, I Hwang, JW Yu, J Karmacharya, HJ Maeng, J Kim, E Jho, SY Ko, H Son, MY Chang, SH Lee |
EMBO Molecular Medicine | 2021 |
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
JB Grigg, A Shanmugavadivu, T Regen, CN Parkhurst, A Ahmed, AM Joseph, M Mazzucco, K Gronke, A Diefenbach, G Eberl, T Vartanian, A Waisman, GF Sonnenberg |
Nature | 2021 |
Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics
O Bulut, G Kilic, J Domínguez-Andrés |
Clinical Reviews in Allergy & Immunology | 2021 |
Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease
SM Carlisle, H Qin, RC Hendrickson, JE Muwanguzi, EJ Lefkowitz, RE Kennedy, Z Yan, TA Yacoubian, EN Benveniste, AB West, AS Harms, DG Standaert |
npj Parkinson's Disease | 2021 |
Protective Effect of the α7 Nicotinic Receptor Agonist PNU-282987 on Dopaminergic Neurons Against 6-Hydroxydopamine, Regulating Anti-neuroinflammatory and the Immune Balance Pathways in Rat.
Jiang Y, Ma H, Wang X, Wang Z, Yang Y, Li L, Feng T |
Frontiers in aging neuroscience | 2021 |
T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils.
George S, Tyson T, Rey NL, Sheridan R, Peelaerts W, Becker K, Schulz E, Meyerdirk L, Burmeister AR, von Linstow CU, Steiner JA, Galvis MLE, Ma J, Pospisilik JA, Labrie V, Brundin L, Brundin P |
Journal of Parkinson's disease | 2021 |
CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease.
Williams GP, Schonhoff AM, Jurkuvenaite A, Gallups NJ, Standaert DG, Harms AS |
Brain : a journal of neurology | 2021 |
Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Safety in Idiopathic Parkinson's Disease.
Schiess M, Suescun J, Doursout MF, Adams C, Green C, Saltarrelli JG, Savitz S, Ellmore TM |
Movement disorders : official journal of the Movement Disorder Society | 2021 |
Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson's Disease.
Lee S, Suh YJ, Lee Y, Yang S, Hong DG, Thirumalai D, Chang SC, Chung KW, Jung YS, Moon HR, Chung HY, Lee J |
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Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background.
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International journal of molecular sciences | 2021 |
LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo.
Van der Perren A, Cabezudo D, Gelders G, Peralta Ramos JM, Van den Haute C, Baekelandt V, Lobbestael E |
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics | 2021 |
Parkinson’s Disease: Can Targeting Inflammation Be an Effective Neuroprotective Strategy?
Gundersen V |
Frontiers in neuroscience | 2021 |
T-cell dysregulation is associated with disease severity in Parkinson’s Disease
Bhatia D, Grozdanov V, Ruf WP, Kassubek J, Ludolph AC, Weishaupt JH, Danzer KM |
Journal of Neuroinflammation | 2021 |
The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations
del Pilar C, Lebrón-Galán R, Pérez-Martín E, Pérez-Revuelta L, Ávila-Zarza CA, Alonso JR, Clemente D, Weruaga E, Díaz D |
Frontiers in cellular neuroscience | 2021 |
CD4+ T cells contribute to neurodegeneration in Lewy body dementia
Gate D, Tapp E, Leventhal O, Shahid M, Nonninger TJ, Yang AC, Strempfl K, Unger MS, Fehlmann T, Oh H, Channappa D, Henderson VW, Keller A, Aigner L, Galasko DR, Davis MM, Poston KL, Wyss-Coray T |
Science (New York, N.Y.) | 2021 |
Infection and Risk of Parkinson's Disease.
Smeyne RJ, Noyce AJ, Byrne M, Savica R, Marras C |
Journal of Parkinson's disease | 2021 |
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
Li W, Luo Y, Xu H, Ma Q, Yao Q |
2021 | |
Evidence for Peripheral Immune Activation in Parkinson’s Disease
Chen X, Feng W, Ou R, Liu J, Yang J, Fu J, Cao B, Chen Y, Wei Q, Shang H |
Frontiers in aging neuroscience | 2021 |
Multi-omic insights into Parkinson’s Disease: from genetic associations to functional mechanisms
Schilder BM, Navarro E, Raj T |
Neurobiology of Disease | 2021 |
RNA sequencing of whole blood reveals early alterations in immune cells and gene expression in Parkinson's disease.
Craig DW, Hutchins E, Violich I, Alsop E, Gibbs JR, Levy S, Robison M, Prasad N, Foroud T, Crawford KL, Toga AW, Whitsett TG, Kim S, Casey B, Reimer A, Hutten SJ, Frasier M, Kern F, Fehlman T, Keller A, Cookson MR, Van Keuren-Jensen K |
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A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus
HM Makinde, DR Winter, D Procissi, EV Mike, AD Stock, MJ Kando, GT Gadhvi, S Droho, CL Bloomfield, ST Dominguez, MG Mayr, JA Lavine, C Putterman, CM Cuda |
Frontiers in immunology | 2020 |
Soluble CD163 Changes Indicate Monocyte Association With Cognitive Deficits in Parkinson's Disease
SK Nissen, SA Ferreira, MC Nielsen, C Schulte, K Shrivastava, D Hennig, A Etzerodt, JH Graversen, D Berg, W Maetzler, A Panhelainen, HJ Møller, K Brockmann, M RomeroRamos |
Movement disorders : official journal of the Movement Disorder Society | 2020 |
Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?
K Mayne, JA White, CE McMurran, FJ Rivera, AG de la Fuente |
Frontiers in aging neuroscience | 2020 |
High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy
A Heras-Garvin, V Refolo, M Reindl, GK Wenning, N Stefanova |
Journal of Neuroinflammation | 2020 |
Glia Crosstalk in Neuroinflammatory Diseases
A Bernaus, S Blanco, A Sevilla |
Frontiers in cellular neuroscience | 2020 |
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
E Pasciuto, OT Burton, CP Roca, V Lagou, WD Rajan, T Theys, R Mancuso, RY Tito, L Kouser, Z Callaerts-Vegh, AG de la Fuente, T Prezzemolo, LG Mascali, A Brajic, CE Whyte, L Yshii, A Martinez-Muriana, M Naughton, A Young, A Moudra, P Lemaitre, S Poovathingal, J Raes, BD Strooper, DC Fitzgerald, J Dooley, A Liston |
Cell | 2020 |
Glycosphingolipids and neuroinflammation in Parkinson’s disease
K Belarbi, E Cuvelier, MA Bonte, M Desplanque, B Gressier, D Devos, MC Chartier-Harlin |
Molecular Neurodegeneration | 2020 |
Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
N Reich, C Hölscher |
Frontiers in neuroscience | 2020 |
Exercise Reverses Dysregulation of T-Cell-Related Function in Blood Leukocytes of Patients With Parkinson's Disease
Y Hu, K Zhang, T Zhang, J Wang, F Chen, W Qin, W Tong, Q Guan, Y He, C Gu, X Chen, UJ Kang, YE Sun, S Li, L Jin |
Frontiers in neurology | 2020 |
Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins
S Chamani, V Bianconi, A Tasbandi, M Pirro, GE Barreto, T Jamialahmadi, A Sahebkar |
Mediators of Inflammation | 2020 |
Critical Neurotransmitters in the Neuroimmune Network
TW Hodo, MT de Aquino, A Shimamoto, A Shanker |
Frontiers in immunology | 2020 |
Lymphocyte-Activation Gene 3 (LAG3) Protein as a Possible Therapeutic Target for Parkinson’s Disease: Molecular Mechanisms Connecting Neuroinflammation to α-Synuclein Spreading Pathology
E Angelopoulou, YN Paudel, C Villa, MF Shaikh, C Piperi |
Biology : open access journal | 2020 |
Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models
K Simmnacher, J Lanfer, T Rizo, J Kaindl, B Winner |
Frontiers in cellular neuroscience | 2020 |
New Insights into Immune-Mediated Mechanisms in Parkinson’s Disease
JS Tan, YX Chao, O Rötzschke, EK Tan |
International journal of molecular sciences | 2020 |
Neurodegeneration and Inflammation—An Interesting Interplay in Parkinson’s Disease
C Marogianni, M Sokratous, E Dardiotis, GM Hadjigeorgiou, D Bogdanos, G Xiromerisiou |
International journal of molecular sciences | 2020 |
Reduction of Peripheral Blood iNKT and γδT Cells in Patients With Parkinson's Disease: An Observational Study
C Zhou, X Zhou, D He, Z Li, X Xie, Y Ren |
Frontiers in immunology | 2020 |
Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration
J He, G Zhu, G Wang, F Zhang |
Oxidative medicine and cellular longevity | 2020 |
Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale
N Ruffini, S Klingenberg, S Schweiger, S Gerber |
Cells | 2020 |
The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols
S Aryal, T Skinner, B Bridges, JT Weber |
Molecules (Basel, Switzerland) | 2020 |
TLR7/8 in the Pathogenesis of Parkinson’s Disease
M Campolo, A Filippone, C Biondo, G Mancuso, G Casili, M Lanza, S Cuzzocrea, E Esposito, I Paterniti |
International journal of molecular sciences | 2020 |
Translation Imaging in Parkinson’s Disease: Focus on Neuroinflammation
S Belloli, M Morari, V Murtaj, S Valtorta, RM Moresco, MC Gilardi |
Frontiers in aging neuroscience | 2020 |
T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease
GP Williams, DJ Marmion, AM Schonhoff, A Jurkuvenaite, WJ Won, DG Standaert, JH Kordower, AS Harms |
Acta Neuropathologica | 2020 |
Battling Neurodegenerative Diseases with Adeno-Associated Virus-Based Approaches
O Mijanović, A Branković, AV Borovjagin, DV Butnaru, EA Bezrukov, RB Sukhanov, A Shpichka, P Timashev, I Ulasov |
Viruses | 2020 |
Role of Peripheral Immune Cells-Mediated Inflammation on the Process of Neurodegenerative Diseases
Q Yang, G Wang, F Zhang |
Frontiers in immunology | 2020 |
Regulatory Roles of Bone in Neurodegenerative Diseases
Z Yu, Z Ling, L Lu, J Zhao, X Chen, P Xu, X Zou |
Frontiers in aging neuroscience | 2020 |
From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
A Heras-Garvin, N Stefanova |
Frontiers in synaptic neuroscience | 2020 |
The Effect of Endurance Training on Brain-Derived Neurotrophic Factor and Inflammatory Markers in Healthy People and Parkinson's Disease. A Narrative Review
P Małczyńska-Sims, M Chalimoniuk, A Sułek |
Frontiers in physiology | 2020 |
Neuroinflammation and protein pathology in Parkinson’s disease dementia
A Kouli, M Camacho, K Allinson, CH Williams-Gray |
Acta Neuropathologica Communications | 2020 |
Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
M Pajares, AI Rojo, G Manda, L Boscá, A Cuadrado |
Cells | 2020 |
Human Adipose Tissue-Derived Mesenchymal Stem Cells in Parkinson’s Disease: Inhibition of T Helper 17 Cell Differentiation and Regulation of Immune Balance Towards a Regulatory T Cell Phenotype Y Bi, X Lin, H Liang, D Yang, X Zhang, J Ke, J Xiao, Z Chen, W Chen, X Zhang, S Wang, CF Liu |
Clinical Interventions in Aging | 2020 |
CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation
D Chakravarty, F Saadi, S Kundu, A Bose, R Khan, K Dine, LC Kenyon, KS Shindler, JD Sarma, S Schultz-Cherry |
Journal of virology | 2020 |
Immune cell regulation of glia during CNS injury and disease
AD Greenhalgh, S David, FC Bennett |
Nature Reviews Neuroscience | 2020 |
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
J Machhi, BD Kevadiya, IK Muhammad, J Herskovitz, KE Olson, RL Mosley, HE Gendelman |
Molecular Neurodegeneration | 2020 |
Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice
KE Olson, KL Namminga, AD Schwab, MJ Thurston, Y Lu, A Woods, L Lei, W Shen, F Wang, SB Joseph, HE Gendelman, RL Mosley |
Neurotherapeutics | 2020 |
Using multi-organ culture systems to study Parkinson’s disease
O Reiner, T Sapir, A Parichha |
Molecular Psychiatry | 2020 |
Inflammation in Experimental Models of α ‐Synucleinopathies
AS Harms, JH Kordower, A Sette, CS Arlehamn, D Sulzer, RH Mach |
Movement disorders : official journal of the Movement Disorder Society | 2020 |
Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson's disease brain.
Rostami J, Fotaki G, Sirois J, Mzezewa R, Bergström J, Essand M, Healy L, Erlandsson A |
Journal of Neuroinflammation | 2020 |
Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease.
Haque A, Samantaray S, Knaryan VH, Capone M, Hossain A, Matzelle D, Chandran R, Shields DC, Farrand AQ, Boger HA, Banik NL |
Experimental Neurology | 2020 |
Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model.
Qiao CM, Sun MF, Jia XB, Li Y, Zhang BP, Zhao LP, Shi Y, Zhou ZL, Zhu YL, Cui C, Shen YQ |
Neurochemical Research | 2020 |
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Schwab AD, Thurston MJ, Machhi J, Olson KE, Namminga KL, Gendelman HE, Mosley RL |
Neurobiology of Disease | 2020 |
Parkinson disease and the immune system - associations, mechanisms and therapeutics.
Tan EK, Chao YX, West A, Chan LL, Poewe W, Jankovic J |
Nature reviews. Neurology | 2020 |
Investigating lymphocyte populations in patients with Parkinson's disease.
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Annals of translational medicine | 2020 |
Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.
Guo X, Pan Y, Xiong M, Sanapala S, Anastasaki C, Cobb O, Dahiya S, Gutmann DH |
Nature Communications | 2020 |
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.
Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E |
Journal of Neuroinflammation | 2020 |
AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia.
Poh L, Fann DY, Wong P, Lim HM, Foo SL, Kang SW, Rajeev V, Selvaraji S, Iyer VR, Parathy N, Khan MB, Hess DC, Jo DG, Drummond GR, Sobey CG, Lai MKP, Chen CL, Lim LHK, Arumugam TV |
Molecular Psychiatry | 2020 |
Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism
Liang T, Qian ZM, Mu MD, Yung WH, Ke Y |
iScience | 2020 |
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease
Li W, Chen S, Luo Y, Xia Y, Ma Q, Yao Q, Wu J |
Experimental and therapeutic medicine | 2020 |
Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells
Panagiotakopoulou V, Ivanyuk D, De Cicco S, Haq W, Arsić A, Yu C, Messelodi D, Oldrati M, Schöndorf DC, Perez MJ, Cassatella RP, Jakobi M, Schneiderhan-Marra N, Gasser T, Nikić-Spiegel I, Deleidi M |
Nature Communications | 2020 |
Glycyrrhizic Acid Improves Cognitive Levels of Aging Mice by Regulating T/B Cell Proliferation
Jiang R, Gao J, Shen J, Zhu X, Wang H, Feng S, Huang C, Shen H, Liu H |
Frontiers in aging neuroscience | 2020 |
RAGE Silencing Ameliorates Neuroinflammation by Inhibition of p38-NF-κB Signaling Pathway in Mouse Model of Parkinson's Disease.
Wang X, Sun X, Niu M, Zhang X, Wang J, Zhou C, Xie A |
Frontiers in neuroscience | 2020 |
Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation.
Cabezudo D, Baekelandt V, Lobbestael E |
Frontiers in neuroscience | 2020 |
Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation.
Campos J, Pacheco R |
Seminars in Immunopathology | 2020 |
Idebenone Ameliorates Rotenone-Induced Parkinson's Disease in Rats Through Decreasing Lipid Peroxidation.
Avcı B, Günaydın C, Güvenç T, Yavuz CK, Kuruca N, Bilge SS |
Neurochemical Research | 2020 |
Elevated Percentage of CD3+ T-Cells and CD4+/CD8+ Ratios in Multiple System Atrophy Patients
Cao B, Chen X, Zhang L, Wei Q, Liu H, Feng W, Chen Y, Shang H |
Frontiers in neurology | 2020 |
Prefrontal cortex transcriptomic deconvolution implicates monocyte infiltration in Parkinson’s disease
Batchu S |
Neurodegenerative Diseases | 2020 |
Dopaminergic signalling limits suppressive activity and gut homing of regulatory T cells upon intestinal inflammation.
Ugalde V, Contreras F, Prado C, Chovar O, Espinoza A, Pacheco R |
Mucosal Immunology | 2020 |
T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease
Subbarayan MS, Hudson C, Moss LD, Nash KR, Bickford PC |
Journal of Neuroinflammation | 2020 |
Azathioprine immunosuppression and disease modification in Parkinson's disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol.
Greenland JC, Cutting E, Kadyan S, Bond S, Chhabra A, Williams-Gray CH |
BMJ Open | 2020 |
Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils
Roux A, Wang X, Becker K, Ma J |
Journal of Parkinson's disease | 2020 |
Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's disease.
Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, Breen DP, Cummins G, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams-Gray CH |
Brain, Behavior, and Immunity | 2020 |
Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity
B Stutz, C Nasrallah, M Nigro, D Curry, ZW Liu, XB Gao, JD Elsworth, L Mintz, TL Horvath |
Molecular Metabolism | 2019 |
A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease
RL Mosley, Y Lu, KE Olson, J Machhi, W Yan, KL Namminga, JR Smith, SJ Shandler, HE Gendelman |
Frontiers in cellular neuroscience | 2019 |
Protective and Regenerative Roles of T Cells in Central Nervous System Disorders
FL Evans, M Dittmer, AG de la Fuente, DC Fitzgerald |
Frontiers in immunology | 2019 |
Innate and adaptive immune responses in Parkinson's disease
Aubrey M Schonhoff, Gregory P Williams, Zachary D Wallen, David G Standaert, Ashley S Harms |
Progress in brain research | 2019 |
Heat-Shock Proteins in Neuroinflammation
B Dukay, B Csoboz, ME Tóth |
Frontiers in pharmacology | 2019 |
Roles for the adaptive immune system in Parkinson’s and Alzheimer’s diseases
CS Arlehamn, F Garretti, D Sulzer, A Sette |
Current Opinion in Immunology | 2019 |
Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1
S Nataf, M Guillen, L Pays |
Frontiers in immunology | 2019 |
B cells in autoimmune and neurodegenerative central nervous system diseases
JJ Sabatino, AK Pröbstel, SS Zamvil |
Nature Reviews Neuroscience | 2019 |
Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
Zuo, Prather, Stetskiv, Garrison, Meade, Peace, Zhou |
International journal of molecular sciences | 2019 |
Immune Signaling in Neurodegeneration
TR Hammond, SE Marsh, B Stevens |
Immunity | 2019 |
Association of LAG3 genetic variation with an increased risk of PD in Chinese female population
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Journal of Neuroinflammation | 2019 |
Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease
SM Matt, PJ Gaskill |
Journal of Neuroimmune Pharmacology | 2019 |
Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice
A Yan, Z Liu, L Song, X Wang, Y Zhang, N Wu, J Lin, Y Liu, Z Liu |
Frontiers in cellular neuroscience | 2019 |
Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age
RR Martins, PS Ellis, RB MacDonald, RJ Richardson, CM Henriques |
Frontiers in Cell and Developmental Biology | 2019 |
Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence
E Storelli, N Cassina, E Rasini, F Marino, M Cosentino |
Frontiers in neurology | 2019 |
Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway
YL Yang, X Cheng, WH Li, M Liu, YH Wang, GH Du |
International journal of molecular sciences | 2019 |
T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis
N Don-Doncow, L Vanherle, Y Zhang, A Meissner |
International journal of molecular sciences | 2019 |
Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease
X Xue, W Zhang, J Zhu, X Chen, S Zhou, Z Xu, G Hu, C Su |
Journal of Cellular and Molecular Medicine | 2019 |
T-Cell-Driven Inflammation as a Mediator of the Gut-Brain Axis Involved in Parkinson's Disease
J Campos-Acuña, D Elgueta, R Pacheco |
Frontiers in immunology | 2019 |
Inflammation, Infectious Triggers, and Parkinson's Disease
E Caggiu, G Arru, S Hosseini, M Niegowska, GP Sechi, IR Zarbo, LA Sechi |
Frontiers in neurology | 2019 |
Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells
F Garretti, D Agalliu, CS Arlehamn, A Sette, D Sulzer |
Frontiers in immunology | 2019 |
Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?
MT Fuzzati-Armentero, S Cerri, F Blandini |
Frontiers in neurology | 2019 |
Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A2 Against MPTP-Induced Parkinson’s Disease in Mice
KH Kim, SY Lee, J Shin, JT Hwang, HN Jeon, H Bae |
Frontiers in aging neuroscience | 2019 |
Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook
B Olson, DL Marks |
Cancers | 2019 |
Dopamine Receptor D3 Expression Is Altered in CD4+ T-Cells From Parkinson's Disease Patients and Its Pharmacologic Inhibition Attenuates the Motor Impairment in a Mouse Model
D Elgueta, F Contreras, C Prado, A Montoya, V Ugalde, O Chovar, R Villagra, C Henríquez, MA Abellanas, MS Aymerich, R Franco, R Pacheco |
Frontiers in immunology | 2019 |
Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat
KL Patrick, SL Bell, CG Weindel, RO Watson |
Frontiers in Cellular and Infection Microbiology | 2019 |
Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA2 Compositions in a Mouse Model of Parkinson’s Disease
KH Kim, M Kim, J Lee, HN Jeon, SH Kim, H Bae |
Toxins | 2019 |
Parkinson’s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation
SK Dutta, S Verma, V Jain, BK Surapaneni, R Vinayek, L Phillips, PP Nair |
Journal of Neurogastroenterology and Motility | 2019 |
Widespread Tau-Specific CD4 T Cell Reactivity in the General Population
CS Arlehamn, J Pham, RN Alcalay, A Frazier, E Shorr, C Carpenter, J Sidney, R Dhanwani, J Agin-Liebes, F Garretti, AW Amara, DG Standaert, EJ Phillips, SA Mallal, B Peters, D Sulzer, A Sette |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation
D Dai, J Yuan, Y Wang, J Xu, C Mao, Y Xiao |
Scientific Reports | 2019 |
Probiotics for Parkinson’s Disease
Gazerani |
International journal of molecular sciences | 2019 |
Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease
QQ Chen, C Haikal, W Li, JY Li |
Frontiers in molecular neuroscience | 2019 |
Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys
S Mondal, SB Rangasamy, A Roy, S Dasarathy, JH Kordower, K Pahan |
Journal of immunology (Baltimore, Md. : 1950) | 2019 |
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses
C Garber, A Soung, LL Vollmer, M Kanmogne, A Last, J Brown, RS Klein |
Nature Neuroscience | 2019 |
RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson's disease
D Dutta, M Kundu, S Mondal, A Roy, S Ruehl, DA Hall, K Pahan |
Neurobiology of Disease | 2019 |
Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions
S Kalampokini, A Becker, K Fassbender, E Lyros, MM Unger |
Parkinson's Disease | 2019 |
Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
C Perner, F Perner, N Gaur, S Zimmermann, OW Witte, FH Heidel, J Grosskreutz, T Prell |
Journal of Neuroinflammation | 2019 |
Translocator Protein Ligand Protects against Neurodegeneration in the MPTP Mouse Model of Parkinsonism
J Gong, ÉM Szego, A Leonov, E Benito, S Becker, A Fischer, M Zweckstetter, T Outeiro, A Schneider |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2019 |
Role of MicroRNAs in Parkinson’s Disease
SY Goh, YX Chao, ST Dheen, EK Tan, SS Tay |
International journal of molecular sciences | 2019 |
Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease
E Palasz, W Niewiadomski, A Gasiorowska, A Wysocka, A Stepniewska, G Niewiadomska |
Frontiers in neurology | 2019 |
18 F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis
BY Chen, C Ghezzi, B Villegas, A Quon, CG Radu, ON Witte, PM Clark |
Journal of Nuclear Medicine | 2019 |
Targeting the Dopaminergic System in Autoimmunity
PM Vidal, R Pacheco |
Journal of Neuroimmune Pharmacology | 2019 |
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
RH Earls, KB Menees, J Chung, J Barber, CA Gutekunst, MG Hazim, JK Lee |
Journal of Neuroinflammation | 2019 |
Microbiome changes: an indicator of Parkinson's disease?
Haikal C, Chen QQ, Li JY |
Translational Neurodegeneration | 2019 |
Dysregulated Long Non-coding RNAs in Parkinson's Disease Contribute to the Apoptosis of Human Neuroblastoma Cells.
Fan Y, Li J, Yang Q, Gong C, Gao H, Mao Z, Yuan X, Zhu S, Xue Z |
Frontiers in neuroscience | 2019 |
Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson's disease.
Sun C, Zhao Z, Yu W, Mo M, Song C, Si Y, Liu Y |
Annals of translational medicine | 2019 |
Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
Anssar TM, Leitzmann MF, Linker RA, Meier C, Becker C, Jick S, Sahm K, Platten M, Hau P, Seliger C |
Cancer Medicine | 2019 |
Peripheral immune biomarkers and neurodegenerative diseases - a prospective cohort study with 20 years of follow-up
Yazdani S, Mariosa D, Hammar N, Andersson J, Ingre C, Walldius G, Fang F |
Annals of Neurology | 2019 |
The Appendix in Parkinson's Disease: From Vestigial Remnant to Vital Organ?
Killinger B, Labrie V |
Journal of Parkinson's disease | 2019 |
Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced Parkinsonian mouse model.
Kim SJ, Ryu MJ, Han J, Jang Y, Lee MJ, Ju X, Ryu I, Lee YL, Oh E, Chung W, Heo JY, Kweon GR |
Laboratory Investigation | 2019 |
Infection triggers symptoms similar to those of Parkinson's disease in mice lacking PINK1 protein.
Herrick MK, Tansey MG |
Nature | 2019 |
Blood-brain barrier opening with focused ultrasound in experimental models of Parkinson's disease.
Karakatsani ME, Blesa J, Konofagou EE |
Movement disorders : official journal of the Movement Disorder Society | 2019 |
Blood biomarkers with Parkinson's disease clusters and prognosis: The oxford discovery cohort
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Movement Disorders | 2019 |
Microglial interactions with the neurovascular system in physiology and pathology: Microglia-Vascular Communication
X Zhao, UB Eyo, M Murugan, LJ Wu |
Developmental Neurobiology | 2018 |
The Role of Immunosenescence in Neurodegenerative Diseases
E Costantini, C DAngelo, M Reale |
Mediators of Inflammation | 2018 |
Neuroinflammation: Microglia and T Cells Get Ready to Tango
ST Schetters, D Gomez-Nicola, JJ Garcia-Vallejo, YV Kooyk |
Frontiers in immunology | 2018 |
Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases
P García-González, F Cabral-Miranda, C Hetz, F Osorio |
Frontiers in immunology | 2018 |
Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson’s Disease
Y Jiang, Z Cao, H Ma, G Wang, X Wang, Z Wang, Y Yang, H Zhao, G Liu, L Li, T Feng |
Neurochemical Research | 2018 |
New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease
G Zhang, Y Xia, F Wan, K Ma, X Guo, L Kou, S Yin, C Han, L Liu, J Huang, N Xiong, T Wang |
Frontiers in aging neuroscience | 2018 |
Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
AS Harms, AD Thome, Z Yan, AM Schonhoff, GP Williams, X Li, Y Liu, H Qin, EN Benveniste, DG Standaert |
Experimental Neurology | 2018 |
Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain
F L'Episcopo, C Tirolo, MF Serapide, S Caniglia, N Testa, L Leggio, S Vivarelli, N Iraci, S Pluchino, B Marchetti |
Frontiers in aging neuroscience | 2018 |
Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients
N Kustrimovic, C Comi, L Magistrelli, E Rasini, M Legnaro, R Bombelli, I Aleksic, F Blandini, B Minafra, G Riboldazzi, A Sturchio, M Mauri, G Bono, F Marino, M Cosentino |
Journal of Neuroinflammation | 2018 |
α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis
LM Butkovich, MC Houser, MG Tansey |
Frontiers in neuroscience | 2018 |
Partial Depletion of Peripheral M1 Macrophages Reverses Motor Deficits in MPTP-Treated Mouse by Suppressing Neuroinflammation and Dopaminergic Neurodegeneration
A Yan, Y Zhang, J Lin, L Song, X Wang, Z Liu |
Frontiers in aging neuroscience | 2018 |
Tolerogenic bone marrow-derived dendritic cells induce neuroprotective regulatory T cells in a model of Parkinson’s disease
CR Schutt, HE Gendelman, RL Mosley |
Molecular Neurodegeneration | 2018 |
Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
C Ising, MT Heneka |
Cell Death and Disease | 2018 |
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells
F Osorio-Barrios, C Prado, F Contreras, R Pacheco |
Frontiers in cellular neuroscience | 2018 |
Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention
SA Ferreira, M Romero-Ramos |
Frontiers in cellular neuroscience | 2018 |
Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
V Ghiglieri, V Calabrese, P Calabresi |
Frontiers in neurology | 2018 |
Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
G Gelders, V Baekelandt, AV der Perren |
Journal of Immunology Research | 2018 |
Emerging Biosensing Technologies for Neuroinflammatory and Neurodegenerative Disease Diagnostics
CM Abreu, R Soares-dos-Reis, PN Melo, JB Relvas, J Guimarães, MJ Sá, AP Cruz, IM Pinto |
Frontiers in molecular neuroscience | 2018 |
Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction
Y Liu, Y Yin |
Mediators of Inflammation | 2018 |
Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases
AU Joshi, D Mochly-Rosen |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2018 |
CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology
MN Olesen, JR Christiansen, SV Petersen, PH Jensen, W Paslawski, M Romero-Ramos, V Sanchez-Guajardo |
Heliyon | 2018 |
Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease
GP Williams, AM Schonhoff, A Jurkuvenaite, AD Thome, DG Standaert, AS Harms |
Journal of Neuroinflammation | 2018 |
NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson’s disease
KM von Herrmann, LA Salas, EM Martinez, AL Young, JM Howard, MS Feldman, BC Christensen, OM Wilkins, SL Lee, WF Hickey, MC Havrda |
npj Parkinson's Disease | 2018 |
Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo
E Bok, YC Chung, KS Kim, HH Baik, WH Shin, BK Jin |
Experimental & molecular medicine | 2018 |
NCX1 and NCX3 as potential factors contributing to neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson’s Disease
R Sirabella, MJ Sisalli, G Costa, K Omura, G Ianniello, A Pinna, M Morelli, GM Renzo, L Annunziato, A Scorziello |
Cell Death and Disease | 2018 |
Abnormalities of age-related T cell senescence in Parkinson’s disease
CH Williams-Gray, RS Wijeyekoon, KM Scott, S Hayat, RA Barker, JL Jones |
Journal of Neuroinflammation | 2018 |
Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion
EG Hain, M Sparenberg, J Rasińska, C Klein, L Akyüz, B Steiner |
Journal of Neuroinflammation | 2018 |
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
MF Duffy, TJ Collier, JR Patterson, CJ Kemp, KC Luk, MG Tansey, KL Paumier, NM Kanaan, DL Fischer, NK Polinski, OL Barth, JW Howe, NN Vaikath, NK Majbour, OM El-Agnaf, CE Sortwell |
Journal of Neuroinflammation | 2018 |
Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice
KE Olson, AN Bade, KL Namminga, MJ Potash, RL Mosley, LY Poluektova, DJ Volsky, HE Gendelman |
Journal of Neurovirology | 2018 |
Depletion of microglia augments the dopaminergic neurotoxicity of MPTP
X Yang, H Ren, K Wood, M Li, S Qiu, FD Shi, C Ma, Q Liu |
The FASEB Journal | 2018 |
Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
R Hussain, H Zubair, S Pursell, M Shahab |
Brain Sciences | 2018 |
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
MS Unger, P Schernthaner, J Marschallinger, H Mrowetz, L Aigner |
Journal of Neuroinflammation | 2018 |
The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?
T Jiang, Li, J Xu, S Gao, X Chen |
Frontiers in immunology | 2018 |
Interaction of systemic oxidative stress and mesial temporal network degeneration in Parkinson’s disease with and without cognitive impairment
PL Chiang, HL Chen, CH Lu, YS Chen, KH Chou, TW Hsu, MH Chen, NW Tsai, SH Li, WC Lin |
Journal of Neuroinflammation | 2018 |
Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
P Troncoso-Escudero, A Parra, M Nassif, RL Vidal |
Frontiers in neurology | 2018 |
Neuroimmunological Implications of Subclinical Lipopolysaccharide from Salmonella Enteritidis
A Mikołajczyk, D Złotkowska |
International journal of molecular sciences | 2018 |
Th17 lymphocyte spearheads the immune attack in Parkinson's disease: New evidence for neuronal death
AW Shukla, SH Fox |
Movement disorders : official journal of the Movement Disorder Society | 2018 |
Curative Anti-Inflammatory Properties of Chinese Optimized Yinxieling Formula in Models of Parkinson’s Disease
RR Wei, J OuYang, WX Lin, TX Lin |
Evidence-Based Complementary and Alternative Medicine | 2018 |
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
I García-Domínguez, K Veselá, J García-Revilla, A Carrillo-Jiménez, MA Roca-Ceballos, M Santiago, RM de Pablos, JL Venero |
Frontiers in cellular neuroscience | 2018 |
Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease
JB Schröder, M Pawlowski, GM zu Hörste, CC Gross, H Wiendl, SG Meuth, T Ruck, T Warnecke |
Frontiers in neurology | 2018 |
Counteracting neuroinflammation in experimental Parkinson’s disease favors recovery of function: effects of Er-NPCs administration
S Carelli, T Giallongo, Z Gombalova, F Rey, MC Gorio, M Mazza, AM Giulio |
Journal of Neuroinflammation | 2018 |
Aging, rather than Parkinson's disease, affects the responsiveness of PBMCs to the immunosuppression of bone marrow mesenchymal stem cells
YQ Guan, CS Zhao, HQ Zou, XM Yan, LL Luo, JL Wu, X Li, Y Zhang |
Molecular medicine reports | 2018 |
Immune system responses in Parkinson's disease: Early and dynamic
MG Tansey, M RomeroRamos |
The European journal of neuroscience | 2018 |
Early microglial activation and peripheral inflammation in dementia with Lewy bodies
A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, PV Rodríguez, WR Bevan-Jones, SA Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT OBrien |
Brain | 2018 |
Microbial treatment: the potential application for Parkinson's disease.
Fang X |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2018 |
Effective effectors: How T cells access and infiltrate the central nervous system.
Congdon KL, Sanchez-Perez LA, Sampson JH |
Pharmacology & Therapeutics | 2018 |
α-Synuclein activates innate immunity but suppresses interferon-γ expression in murine astrocytes.
Wang J, Chen Z, Walston JD, Gao P, Gao M, Leng SX |
The European journal of neuroscience | 2018 |
Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo.
Kozina E, Sadasivan S, Jiao Y, Dou Y, Ma Z, Tan H, Kodali K, Shaw T, Peng J, Smeyne RJ |
Brain : a journal of neurology | 2018 |
Prion-like mechanisms in Parkinson Disease
Volpicelli-Daley L, Brundin P |
Handbook of Clinical Neurology | 2018 |
Th17 cells in Parkinson’s disease: the bane of the midbrain
Bolte AC, Lukens JR |
Cell Stem Cell | 2018 |
CNS inflammation and neurodegeneration
Tanuja Chitnis, Howard L. Weiner |
Journal of Clinical Investigation | 2017 |
Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson's Disease
JA Korecka, EB Moloney, R Eggers, B Hobo, S Scheffer, N Ras-Verloop, RJ Pasterkamp, DF Swaab, AB Smit, RE van Kesteren, K Bossers, J Verhaagen |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2017 |
CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease
SR Stott, S Hayat, T Carnwath, S Garas, JP Sleeman, RA Barker, RJ Smeyne |
PloS one | 2017 |
The Oxygen Paradox, the French Paradox, and age-related diseases
JM Davies, J Cillard, B Friguet, E Cadenas, J Cadet, R Cayce, A Fishmann, D Liao, AL Bulteau, F Derbré, A Rébillard, S Burstein, E Hirsch, RA Kloner, M Jakowec, G Petzinger, D Sauce, F Sennlaub, I Limon, F Ursini, M Maiorino, C Economides, CJ Pike, P Cohen, AN Salvayre, MR Halliday, AJ Lundquist, NA Jakowec, F Mechta-Grigoriou, M Mericskay, J Mariani, Z Li, D Huang, E Grant, HJ Forman, CE Finch, PY Sun, LC Pomatto, O Agbulut, D Warburton, C Neri, M Rouis, P Cillard, J Capeau, J Rosenbaum, KJ Davies |
GeroScience | 2017 |
Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism
A Anandhan, MS Jacome, S Lei, P Hernandez-Franco, A Pappa, MI Panayiotidis, R Powers, R Franco |
Brain Research Bulletin | 2017 |
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition
A Terron, A Bal-Price, A Paini, F Monnet-Tschudi, SH Bennekou, M Leist, S Schildknecht |
Archives of Toxicology | 2017 |
Let’s make microglia great again in neurodegenerative disorders
MV Guillot-Sestier, T Town |
Journal of Neural Transmission | 2017 |
Autoimmune Aspects of Neurodegenerative and Psychiatric Diseases: A Template for Innovative Therapy
P Haan, HC Klein, BA Hart |
Frontiers in Psychiatry | 2017 |
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
D Sulzer, RN Alcalay, F Garretti, L Cote, E Kanter, J Agin-Liebes, C Liong, C McMurtrey, WH Hildebrand, X Mao, VL Dawson, TM Dawson, C Oseroff, J Pham, J Sidney, MB Dillon, C Carpenter, D Weiskopf, E Phillips, S Mallal, B Peters, A Frazier, CS Arlehamn, A Sette |
Nature | 2017 |
Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat
G Ambrosi, N Kustrimovic, F Siani, E Rasini, S Cerri, C Ghezzi, G Dicorato, S Caputo, F Marino, M Cosentino, F Blandini |
Neurotoxicity Research | 2017 |
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
RH Swerdlow, HM Wilkins, IW Weidling, Y Ji |
Frontiers in immunology | 2017 |
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
SR Subramaniam, HJ Federoff |
Frontiers in aging neuroscience | 2017 |
Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
P Thakur, LS Breger, M Lundblad, OW Wan, B Mattsson, KC Luk, VM Lee, JQ Trojanowski, A Björklund |
Proceedings of the National Academy of Sciences | 2017 |
Analysis of monocyte infiltration in MPTP mice reveals that microglial CX3CR1 protects against neurotoxic over-induction of monocyte-attracting CCL2 by astrocytes
VR Parillaud, G Lornet, Y Monnet, AL Privat, AT Haddad, V Brochard, A Bekaert, CB de Chanville, EC Hirsch, C Combadière, S Hunot, CS Lobsiger |
Journal of Neuroinflammation | 2017 |
Peripheral Lymphocyte Subsets as a Marker of Parkinson’s Disease in a Chinese Population
L Cen, C Yang, S Huang, M Zhou, X Tang, K Li, W Guo, Z Wu, M Mo, Y Xiao, X Chen, X Yang, Q Huang, C Chen, S Qu, P Xu |
Neuroscience Bulletin | 2017 |
Evaluation of the safety and immunomodulatory effects of sargramostim in a randomized, double-blind phase 1 clinical Parkinson’s disease trial
HE Gendelman, Y Zhang, P Santamaria, KE Olson, CR Schutt, D Bhatti, BL Shetty, Y Lu, KA Estes, DG Standaert, E Heinrichs-Graham, LA Larson, JL Meza, M Follett, E Forsberg, G Siuzdak, TW Wilson, C Peterson, RL Mosley |
npj Parkinson's Disease | 2017 |
Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease
Q Zhang, Y Heng, Z Mou, J Huang, Y Yuan, N Chen |
Acta Pharmacologica Sinica | 2017 |
Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila
SC Wu, ZS Cao, KM Chang, JL Juang |
Nature Communications | 2017 |
Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease
G Chandra, A Roy, SB Rangasamy, K Pahan |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels
JY Choi, SS Yoon, SE Kim, SA Jo |
Scientific Reports | 2017 |
A Novel Immunosuppressor, (5R)-5-Hydroxytriptolide, Alleviates Movement Disorder and Neuroinflammation in a 6-OHDA Hemiparkinsonian Rat Model
R Su, M Sun, W Wang, J Zhang, L Zhang, J Zhen, Y Qian, Y Zheng, X Wang |
Aging and disease | 2017 |
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease
H Lee, WS James, SA Cowley |
Biochemical Society Transactions | 2017 |
Autoimmunity as a Driving Force of Cognitive Evolution
S Nataf |
Frontiers in neuroscience | 2017 |
The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases
A Sommer, B Winner, I Prots |
Molecular Neurodegeneration | 2017 |
Vanishing cerebral vasculitis in a patient with Lewy pathology
Natalia Liapounova, Kamran H Azar, J Max Findlay, Jian-Qiang Lu |
Journal of Biomedical Research | 2017 |
The role of peripheral immune cells in the CNS in steady state and disease
M Prinz, J Priller |
Nature Neuroscience | 2017 |
Evidence for association between hepatitis C virus and Parkinson's disease.
Abushouk AI, El-Husseny MWA, Magdy M, Ismail A, Attia A, Ahmed H, Pallanti R, Negida A |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2017 |
TGF-β1 Neuroprotection via Inhibition of Microglial Activation in a Rat Model of Parkinson's Disease.
Chen X, Liu Z, Cao BB, Qiu YH, Peng YP |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 2017 |
Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson’s Disease Patients: Search for a Disease Indicator
Yang L, Guo C, Zhu J, Feng Y, Chen W, Feng Z, Wang D, Sun S, Lin W, Wang Y |
Medical science monitor : international medical journal of experimental and clinical research | 2017 |
The correlation of lymphocyte subsets, natural killer cell, and Parkinson's disease: a meta-analysis.
Jiang S, Gao H, Luo Q, Wang P, Yang X |
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology | 2017 |
Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases
Z Yan, SA Gibson, JA Buckley, H Qin, EN Benveniste |
Clinical Immunology | 2016 |
Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson’s Disease-Lessons from Transgenic Mice
V Machado, T Zöller, A Attaai, B Spittau |
International journal of molecular sciences | 2016 |
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease
LC Graham, JM Harder, I Soto, WN de Vries, SW John, GR Howell |
Scientific Reports | 2016 |
Immune-mediated processes in neurodegeneration: where do we stand?
M Fakhoury |
Journal of Neurology | 2016 |
CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson’s disease
YC Chung, WH Shin, JY Baek, EJ Cho, HH Baik, SR Kim, SY Won, BK Jin |
Experimental & molecular medicine | 2016 |
Protective Microglia and Their Regulation in Parkinson’s Disease
W Le, J Wu, Y Tang |
Frontiers in molecular neuroscience | 2016 |
Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases
DG Walker, LF Lue, G Serrano, CH Adler, JN Caviness, LI Sue, TG Beach |
Frontiers in neuroscience | 2016 |
Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson’s Disease
N Kustrimovic, E Rasini, M Legnaro, R Bombelli, I Aleksic, F Blandini, C Comi, M Mauri, B Minafra, G Riboldazzi, V Sanchez-Guajardo, F Marino, M Cosentino |
Scientific Reports | 2016 |
Pink Light on Mitochondria in Autoimmunity and Parkinson Disease
AR Mantegazza, MS Marks |
Cell Metabolism | 2016 |
Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model
A Sommer, T Fadler, E Dorfmeister, AC Hoffmann, W Xiang, B Winner, I Prots |
Journal of Neuroinflammation | 2016 |
Manganese-Enhanced Magnetic Resonance Imaging for Detection of Vasoactive Intestinal Peptide Receptor 2 Agonist Therapy in a Model of Parkinson’s Disease
KE Olson, AN Bade, CR Schutt, J Dong, SJ Shandler, MD Boska, RL Mosley, HE Gendelman, Y Liu |
Neurotherapeutics | 2016 |
Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons
S Wang, CH Chu, M Guo, L Jiang, H Nie, W Zhang, B Wilson, L Yang, T Stewart, JS Hong, J Zhang |
Journal of Neuroinflammation | 2016 |
Central Nervous System-Peripheral Immune System Dialogue in Neurological Disorders: Possible Application of Neuroimmunology in Urology
HS Park, MJ Park, MS Kwon |
International Neurourology Journal | 2016 |
Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease
G Chandra, SB Rangasamy, A Roy, JH Kordower, K Pahan |
The Journal of biological chemistry | 2016 |
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease
R Gordon, N Singh, V Lawana, A Ghosh, DS Harischandra, H Jin, C Hogan, S Sarkar, D Rokad, N Panicker, V Anantharam, AG Kanthasamy, A Kanthasamy |
Neurobiology of Disease | 2016 |
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology
JR Christiansen, MN Olesen, DE Otzen, M Romero-Ramos, V Sanchez-Guajardo |
Journal of Neuroinflammation | 2016 |
Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes
MK Shimabukuro, LG Langhi, I Cordeiro, JM Brito, CM de Batista, MP Mattson, VM Coelho |
Scientific Reports | 2016 |
Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD): Serum Immune Markers and PD Progression
CH Williams-Gray, R Wijeyekoon, AJ Yarnall, RA Lawson, DP Breen, JR Evans, GA Cummins, GW Duncan, TK Khoo, DJ Burn, RA Barker |
Movement disorders : official journal of the Movement Disorder Society | 2016 |
Microglia-Derived Cytokines/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice
CH Chien, MJ Lee, HC Liou, HH Liou, WM Fu, ML Block |
PloS one | 2016 |
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease
AD Thome, AS Harms, LA Volpicelli-Daley, DG Standaert |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies
IL González, P Garcia-Esparcia, F Llorens, I Ferrer |
International journal of molecular sciences | 2016 |
Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms
C Figueroa-Romero, J Hur, JS Lunn, X Paez-Colasante, DE Bender, R Yung, SA Sakowski, EL Feldman |
Molecular and Cellular Neuroscience | 2016 |
Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease
KE Olson, HE Gendelman |
Current Opinion in Pharmacology | 2016 |
Serum Lymphocyte-Associated Cytokine Concentrations Change More Rapidly over Time in Multiple System Atrophy Compared to Parkinson Disease
K Csencsits-Smith, J Suescun, K Li, S Luo, DL Bick, M Schiess |
Neuroimmunomodulation | 2016 |
Rho kinase II interference by small hairpin RNA ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
Q Zhang, YF Zhao, JY Xi, WB Yu, BG Xiao |
Molecular medicine reports | 2016 |
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration
H Qin, JA Buckley, X Li, Y Liu, TH Fox, GP Meares, H Yu, Z Yan, AS Harms, Y Li, DG Standaert, EN Benveniste |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model
N Tentillier, A Etzerodt, MN Olesen, FS Rizalar, J Jacobsen, D Bender, SK Moestrup, M Romero-Ramos |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2016 |
Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson's Disease.
Liu Z, Huang Y, Cao BB, Qiu YH, Peng YP |
Molecular Neurobiology | 2016 |
Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy
LJ Blair, HD Frauen, B Zhang, BA Nordhues, S Bijan, YC Lin, F Zamudio, LD Hernandez, JJ Sabbagh, ML Selenica, CA Dickey |
Acta Neuropathologica Communications | 2015 |
Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging
B Coder, W Wang, L Wang, Z Wu, Q Zhuge, DM Su |
Oncotarget | 2015 |
Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes
EH Rannikko, SS Weber, PJ Kahle |
BMC neuroscience | 2015 |
Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
C Späni, T Suter, R Derungs, MT Ferretti, T Welt, F Wirth, C Gericke, RM Nitsch, L Kulic |
Acta Neuropathologica Communications | 2015 |
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
B Dehay, M Bourdenx, P Gorry, S Przedborski, M Vila, S Hunot, A Singleton, CW Olanow, KM Merchant, E Bezard, GA Petsko, WG Meissner |
The Lancet Neurology | 2015 |
Relevance of chronic stress and the two faces of microglia in Parkinson’s disease
AJ Herrera, AM Espinosa-Oliva, A Carrillo-Jiménez, MJ Oliva-Martín, J García-Revilla, A García-Quintanilla, RM de Pablos, JL Venero |
Frontiers in cellular neuroscience | 2015 |
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
FA Zucca, J Segura-Aguilar, E Ferrari, P Muñoz, I Paris, D Sulzer, T Sarna, L Casella, L Zecca |
Progress in Neurobiology | 2015 |
Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8+ T cells in the nigra of hemiparkinsonian monkey
A Roy, S Mondal, JH Kordower, K Pahan |
Neuroscience | 2015 |
Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice
L Gao, D Brenner, E Llorens-Bobadilla, G Saiz-Castro, T Frank, P Wieghofer, O Hill, M Thiemann, S Karray, M Prinz, JH Weishaupt, A Martin-Villalba |
Journal of Experimental Medicine | 2015 |
Anti-Human α-Synuclein N-Terminal Peptide Antibody Protects against Dopaminergic Cell Death and Ameliorates Behavioral Deficits in an AAV-α-Synuclein Rat Model of Parkinson’s Disease
M Shahaduzzaman, K Nash, C Hudson, M Sharif, B Grimmig, X Lin, G Bai, H Liu, KE Ugen, C Cao, PC Bickford |
PloS one | 2015 |
Effects of inflammation on stem cells: together they strive?
C Kizil, N Kyritsis, M Brand |
EMBO reports | 2015 |
Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease
Heather E. Allen Reish, David G. Standaert |
Journal of Parkinson's disease | 2015 |
Low-variance RNAs identify Parkinson's disease molecular signature in blood: New Blood Biomarkers of PD
MD Chikina, CP Gerald, X Li, Y Ge, H Pincas, VD Nair, AK Wong, A Krishnan, OG Troyanskaya, D Raymond, R Saunders-Pullman, SB Bressman, Z Yue, SC Sealfon |
Movement disorders : official journal of the Movement Disorder Society | 2015 |
Striatal blood–brain barrier permeability in Parkinson’s disease
MT Gray, JM Woulfe |
Journal of Cerebral Blood Flow & Metabolism | 2015 |
Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration
S Theofilopoulos, E Arenas |
F1000prime reports | 2015 |
Immune aging, dysmetabolism, and inflammation in neurological diseases
M Deleidi, M Jäggle, G Rubino |
Frontiers in neuroscience | 2015 |
Baseline C-Reactive Protein Levels and Life Prognosis in Parkinson Disease
H Sawada, T Oeda, A Umemura, S Tomita, M Kohsaka, K Park, K Yamamoto, H Sugiyama, K Hashimoto |
PloS one | 2015 |
Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model
R Dutta, S Roy |
Journal of Neuroinflammation | 2015 |
Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice
S Samantaray, VH Knaryan, DC Shields, AA Cox, A Haque, NL Banik |
Molecular Neurobiology | 2015 |
Neuroinflammation in Parkinson’s disease and its potential as therapeutic target
Q Wang, Y Liu, J Zhou |
Translational Neurodegeneration | 2015 |
Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease
KE Ugen, X Lin, G Bai, Z Liang, J Cai, K Li, S Song, C Cao, J Sanchez-Ramos |
Human Vaccines & Immunotherapeutics | 2015 |
Are Microglial Cells the Regulators of Lymphocyte Responses in the CNS?
B Almolda, B González, B Castellano |
Frontiers in cellular neuroscience | 2015 |
Myeloid Dendritic Cells are Potential Players in Human Neurodegenerative Diseases
P Bossù, G Spalletta, C Caltagirone, A Ciaramella |
Frontiers in immunology | 2015 |
Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study
GT Kannarkat, DA Cook, JK Lee, J Chang, J Chung, E Sandy, KC Paul, B Ritz, J Bronstein, SA Factor, JM Boss, MG Tansey |
npj Parkinson's Disease | 2015 |
Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice
KE Olson, LM Kosloski-Bilek, KM Anderson, BJ Diggs, BE Clark, JM Gledhill, SJ Shandler, RL Mosley, HE Gendelman |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2015 |
Substance P and its tachykinin NK1 receptor: a novel neuroprotective target for Parkinson′s disease
E Thornton, R Vink |
NEURAL REGEN RES | 2015 |
Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease: MHC II Ablation Attenuates MPTP Toxicity
HL Martin, M Santoro, S Mustafa, G Riedel, JV Forrester, P Teismann |
Glia | 2015 |
Fractalkine Signaling Regulates the Inflammatory Response in an α-Synuclein Model of Parkinson Disease
AD Thome, DG Standaert, AS Harms, MG Tansey |
PloS one | 2015 |
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia
P Ejlerskov, JG Hultberg, JY Wang, R Carlsson, M Ambjørn, M Kuss, Y Liu, G Porcu, K Kolkova, C Friis Rundsten, K Ruscher, B Pakkenberg, T Goldmann, D Loreth, M Prinz, DC Rubinsztein, S Issazadeh-Navikas |
Cell | 2015 |
Parkinson’s disease and enhanced inflammatory response
I Stojkovska, BM Wagner, BE Morrison |
Experimental biology and medicine (Maywood, N.J.) | 2015 |
Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells
H González, F Contreras, R Pacheco |
Journal of Neuroimmune Pharmacology | 2015 |
The Role of Neuroinflammation in Dementias
G Pasqualetti, DJ Brooks, P Edison |
Current Neurology and Neuroscience Reports | 2015 |
New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation.
Trudler D, Nash Y, Frenkel D |
Journal of neural transmission (Vienna, Austria : 1996) | 2015 |
Adaptive Immunity in Schizophrenia: Functional Implications of T Cells in the Etiology, Course and Treatment.
Debnath M |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 2015 |
Lymphocytes reduce nigrostriatal deficits in the 6-hydroxydopamine mouse model of Parkinson's disease.
Ip CW, Beck SK, Volkmann J |
Journal of neural transmission (Vienna, Austria : 1996) | 2015 |
Nanowire array chips for molecular typing of rare trafficking leukocytes with application to neurodegenerative pathology
M Kwak, DJ Kim, MR Lee, Y Wu, L Han, SK Lee, R Fan |
Nanoscale | 2014 |
The Dopaminergic System in Autoimmune Diseases
R Pacheco, F Contreras, M Zouali |
Frontiers in immunology | 2014 |
T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases
H González, R Pacheco |
Journal of Neuroinflammation | 2014 |
The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease
MA Lynch |
Immunology | 2014 |
The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
KR Doty, MV Guillot-Sestier, T Town |
Brain Research | 2014 |
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
C Cebrián, FA Zucca, P Mauri, JA Steinbeck, L Studer, CR Scherzer, E Kanter, S Budhu, J Mandelbaum, JP Vonsattel, L Zecca, JD Loike, D Sulzer |
Nature Communications | 2014 |
Immune Responses in Parkinson's Disease: Interplay between Central and Peripheral Immune Systems
X Su, HJ Federoff |
BioMed Research International | 2014 |
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
G Olmos, J Lladó |
Mediators of Inflammation | 2014 |
Opposite effects of bone marrow-derived cells transplantation in MPTP-rat model of Parkinson's disease: a comparison study of mononuclear and mesenchymal stem cells
CS Capitelli, CS Lopes, AC Alves, J Barbiero, LF Oliveira, VJ da Silva, MA Vital |
International journal of medical sciences | 2014 |
Evidence of inflammatory system involvement in Parkinson's disease
Y Chao, SC Wong, EK Tan |
BioMed Research International | 2014 |
Damage of neuroblastoma cell SH-SY5Y mediated by MPP+ inhibits proliferation of T-cell leukemia Jurkat by co-culture system
F Wang, UF Awan, Y Wang, L Wang, H Qing, H Ma, Y Deng |
International journal of molecular sciences | 2014 |
Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease
F L’Episcopo, C Tirolo, S Caniglia, N Testa, MC Morale, MF Serapide, S Pluchino, B Marchetti |
Journal of Molecular Cell Biology | 2014 |
Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases
C Cebrián, JD Loike, D Sulzer |
Frontiers in neuroanatomy | 2014 |
Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders
KM Anderson, KE Olson, KA Estes, K Flanagan, HE Gendelman, R Mosley |
Translational Neurodegeneration | 2014 |
T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson’s Disease
CJ Wheeler |
Journal of Neurology & Neurophysiology | 2014 |
Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
V Grozdanov, C Bliederhaeuser, WP Ruf, V Roth, K Fundel-Clemens, L Zondler, D Brenner, A Martin-Villalba, B Hengerer, J Kassubek, AC Ludolph, JH Weishaupt, KM Danzer |
Acta Neuropathologica | 2014 |
Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype: Immunization with Hsp70-Chaperoned α-Synuclein
A Labrador-Garrido, M Cejudo-Guillén, R Klippstein, EJ de Genst, L Tomas-Gallardo, MM Leal, J Villadiego, JJ Toledo-Aral, CM Dobson, D Pozo, C Roodveldt |
Immunity, Inflammation and Disease | 2014 |
Microglia Development and Function*
D Nayak, TL Roth, DB McGavern |
Annual Review of Immunology | 2014 |
Vaccination strategies for Parkinson disease: Induction of a swift attack or raising tolerance?
Romero-Ramos M, von Euler Chelpin M, Sanchez-Guajardo V |
Human Vaccines & Immunotherapeutics | 2014 |
Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent.
Garcia-Esparcia P, Llorens F, Carmona M, Ferrer I |
Brain Pathology | 2014 |
MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration
AS Harms, S Cao, AL Rowse, AD Thome, X Li, LR Mangieri, RQ Cron, JJ Shacka, C Raman, DG Standaert |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2013 |
The role of inflammation in sporadic and familial Parkinson’s disease
M Deleidi, T Gasser |
Cellular and Molecular Life Sciences | 2013 |
Viruses and neurodegeneration
L Zhou, M Miranda-Saksena, NK Saksena |
Virology Journal | 2013 |
Integrating pathways of Parkinson's disease in a molecular interaction map
KA Fujita, M Ostaszewski, Y Matsuoka, S Ghosh, E Glaab, C Trefois, I Crespo, TM Perumal, W Jurkowski, PM Antony, N Diederich, M Buttini, A Kodama, VP Satagopam, S Eifes, AD Sol, R Schneider, H Kitano, R Balling |
Molecular Neurobiology | 2013 |
Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease
F Blandini |
Journal of Neuroimmune Pharmacology | 2013 |
Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
G Laćan, H Dang, B Middleton, MA Horwitz, J Tian, WP Melega, DL Kaufman |
Journal of Neuroscience Research | 2013 |
Cellular therapy to target neuroinflammation in amyotrophic lateral sclerosis
F Rizzo, G Riboldi, S Salani, M Nizzardo, C Simone, S Corti, E Hedlund |
Experientia | 2013 |
Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation
C Barcia, I Mitxitorena, MA Sauvage, JM Gallego, A Pérez-Vallés, C Barcia |
Frontiers in cellular neuroscience | 2013 |
MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's disease
YC Chung, YS Kim, E Bok, TY Yune, S Maeng, BK Jin |
Mediators of Inflammation | 2013 |
Glial-mediated inflammation underlying parkinsonism
C Barcia |
Scientifica | 2013 |
Cellular and molecular mediators of neuroinflammation in the pathogenesis of Parkinson's disease
SV More, H Kumar, IS Kim, SY Song, DK Choi |
Mediators of Inflammation | 2013 |
Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity
V Sanchez-Guajardo, CJ Barnum, MG Tansey, M Romero-Ramos |
ASN NEURO | 2013 |
PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice
MB Watson, H Nobuta, C Abad, SK Lee, N Bala, C Zhu, F Richter, MF Chesselet, JA Waschek |
Neuroscience | 2013 |
Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
C Noelker, L Morel, T Lescot, A Osterloh, D Alvarez-Fischer, M Breloer, C Henze, C Depboylu, D Skrzydelski, PP Michel, RC Dodel, L Lu, EC Hirsch, S Hunot, A Hartmann |
Scientific Reports | 2013 |
The role of innate and adaptive immunity in Parkinson's disease
GT Kannarkat, JM Boss, MG Tansey |
Journal of Parkinson's disease | 2013 |
GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice
LM Kosloski, EA Kosmacek, KE Olson, RL Mosley, HE Gendelman |
Journal of Neuroimmunology | 2013 |
Critical role of calpain in spinal cord degeneration in Parkinson's disease
S Samantaray, VH Knaryan, DC Shields, NL Banik |
Journal of Neurochemistry | 2013 |
Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function: Molecular immunology
GI Ellis, L Zhi, R Akundi, H Büeler, F Marti |
European Journal of Immunology | 2013 |
The immunology of neurodegeneration
Eva Czirr, Tony Wyss-Coray |
Journal of Clinical Investigation | 2012 |
Aspects of Innate Immunity and Parkinson’s Disease
Y Huang, GM Halliday |
Frontiers in pharmacology | 2012 |
Inflammation and Adaptive Immunity in Parkinson’s Disease
RL Mosley, JA Hutter-Saunders, DK Stone, HE Gendelman |
Cold Spring Harbor Perspectives in Medicine | 2012 |
Treatment with a Substance P Receptor Antagonist Is Neuroprotective in the Intrastriatal 6-Hydroxydopamine Model of Early Parkinson's Disease
E Thornton, R Vink |
PloS one | 2012 |
Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?
E Greggio, L Civiero, M Bisaglia, L Bubacco |
Journal of Neuroinflammation | 2012 |
Markov Chain Ontology Analysis (MCOA)
HR Frost, AT McCray |
BMC bioinformatics | 2012 |
A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
P Holmans, V Moskvina, L Jones, M Sharma, A Vedernikov, F Buchel, M Sadd, JM Bras, F Bettella, N Nicolaou, J Simon-Sanchez, F Mittag, JR Gibbs, C Schulte, A Durr, R Guerreiro, D Hernandez, A Brice, H Stefansson, K Majamaa, T Gasser, P Heutink, NW Wood, M Martinez, AB Singleton, MA Nalls, J Hardy, HR Morris, NM Williams, S Arepalli, R Barker, J Barrett, Y Ben-Shlomo, HW Berendse, D Berg, K Bhatia, RM de Bie, A Biffi, B Bloem, A Brice, Z Bochdanovits, M Bonin, JM Bras, K Brockmann, J Brooks, DJ Burn, G Charlesworth, H Chen, PF Chinnery, S Chong, CE Clarke, MR Cookson, JM Cooper, JC Corvol, C Counsell, P Damier, JF Dartigues, P Deloukas, G Deuschl, DT Dexter, KD van Dijk, A Dillman, F Durif, A Durr, S Edkins, JR Evans, T Foltynie, J Gao, M Gardner, T Gasser, JR Gibbs, A Goate, E Gray, R Guerreiro, O Gustafsson, J Hardy, C Harris, DG Hernandez, P Heutink, JJ van Hilten, A Hofman, A Hollenbeck, P Holmans, J Holton, M Hu, H Huber, G Hudson, SE Hunt, J Huttenlocher, T Illig, C Langford, A Lees, S Lesage, P Lichtner, P Limousin, G Lopez, D Lorenz, M Martinez, A McNeill, C Moorby, M Moore, H Morris, KE Morrison, V Moskvina, E Mudanohwo, MA Nalls, J Pearson, JS Perlmutter, H Petursson, V Plagnol, P Pollak, B Post, S Potter, B Ravina, T Revesz, O Riess, F Rivadeneira, P Rizzu, M Ryten, M Saad, S Sawcer, A Schapira, H Scheffer, M Sharma, K Shaw, UM Sheerin, I Shoulson, C Schulte, E Sidransky, J Simon-Sanchez, AB Singleton, C Smith, H Stefansson, K Stefansson, S Steinberg, JD Stockton, S Sveinbjornsdottir, K Talbot, CM Tanner, A Tashakkori-Ghanbaria, F Tison, D Trabzuni, BJ Traynor, AG Uitterlinden, D Velseboer, M Vidailhet, R Walker, B de Warrenburg, M Wickremaratchi, N Williams, CH Williams-Gray, S Winder-Rhodes, N Wood |
Human Molecular Genetics | 2012 |
Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage
WB Rolland, T Lekic, PR Krafft, Y Hasegawa, O Altay, R Hartman, R Ostrowski, A Manaenko, J Tang, JH Zhang |
Experimental Neurology | 2012 |
The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia
S Cao, DG Standaert, AS Harms |
Journal of Neuroinflammation | 2012 |
HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population
C Sun, L Wei, F Luo, Y Li, J Li, F Zhu, P Kang, R Xu, L Xiao, Z Liu, P Xu |
PloS one | 2012 |
The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease
JM Morganti, KR Nash, BA Grimmig, S Ranjit, B Small, PC Bickford, C Gemma |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2012 |
Differential expression of nerve injury-induced protein 1 (ninjurin 1) in in vivo and in vitro models for diabetic erectile dysfunction
DK Kim, GN Yin, JK Ryu, JK Suh |
Korean Journal of Urology | 2012 |
CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease
JA Saunders, KA Estes, LM Kosloski, HE Allen, KM Dempsey, DR Torres-Russotto, JL Meza, PM Santamaria, JM Bertoni, DL Murman, HH Ali, DG Standaert, RL Mosley, HE Gendelman |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 2012 |
Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease
I St-Amour, M Bousquet, I Paré, J Drouin-Ouellet, F Cicchetti, R Bazin, F Calon |
Journal of Neuroinflammation | 2012 |
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
MB Watson, F Richter, SK Lee, L Gabby, J Wu, E Masliah, RB Effros, MF Chesselet |
Experimental Neurology | 2012 |
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?
CM Tomé, T Tyson, NL Rey, S Grathwohl, M Britschgi, P Brundin |
Molecular Neurobiology | 2012 |
A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice
MF Chesselet, F Richter, C Zhu, I Magen, MB Watson, SR Subramaniam |
Neurotherapeutics | 2012 |
Innate inflammation in Parkinson's disease
VH Perry |
Cold Spring Harbor Perspectives in Medicine | 2012 |
Mechanisms of Altered Redox Regulation in Neurodegenerative Diseases—Focus on S-Glutathionylation
EA Liedhegner, XH Gao, JJ Mieyal |
Antioxidants & Redox Signaling | 2012 |
Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration
JR Sundaram, ES Chan, CP Poore, TK Pareek, WF Cheong, G Shui, N Tang, CM Low, MR Wenk, S Kesavapany |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2012 |
Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?
Carta AR, Pisanu A |
Neurotoxicity Research | 2012 |
Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons
A Machado, AJ Herrera, JL Venero, M Santiago, RM de Pablos, RF Villarán, AM Espinosa-Oliva, S Argüelles, M Sarmiento, MJ Delgado-Cortés, R Mauriño, J Cano |
ISRN Neurology | 2011 |
Inflammation in the early stages of neurodegenerative pathology
PJ Khandelwal, AM Herman, CE Moussa |
Journal of Neuroimmunology | 2011 |
Parkinson's Disease and Systemic Inflammation
CC Ferrari, R Tarelli |
Parkinson's Disease | 2011 |
Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence
A Machado, AJ Herrera, JL Venero, M Santiago, RM de Pablos, RF Villarán, AM Espinosa-Oliva, S Argüelles, M Sarmiento, MJ Delgado-Cortés, R Mauriño, J Cano |
Parkinson's Disease | 2011 |
The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease
KU Tufekci, S Genc, K Genc |
Parkinson's Disease | 2011 |
Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?
AR Carta, A Pisanu, E Carboni |
Parkinson's Disease | 2011 |
Inflammatory Mechanisms of Neurodegeneration in Toxin-Based Models of Parkinson's Disease
D Litteljohn, E Mangano, M Clarke, J Bobyn, K Moloney, S Hayley |
Parkinson's Disease | 2011 |
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
L Fellner, KA Jellinger, GK Wenning, N Stefanova |
Acta Neuropathologica | 2011 |
Involvement of the Fcγ Receptor in a Chronic N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Dopaminergic Loss*
A Lira, J Kulczycki, R Slack, H Anisman, DS Park |
The Journal of biological chemistry | 2011 |
BCG Vaccine-Induced Neuroprotection in a Mouse Model of Parkinson's Disease
J Yong, G Lacan, H Dang, T Hsieh, B Middleton, C Wasserfall, J Tian, WP Melega, DL Kaufman |
PloS one | 2011 |
Axonal Damage in Multiple Sclerosis
JD Haines, M Inglese, P Casaccia |
The Mount Sinai journal of medicine, New York | 2011 |
Regulation by Glycogen Synthase Kinase-3 of Inflammation and T Cells in CNS Diseases
E Beurel |
Frontiers in molecular neuroscience | 2011 |
Immunolocalization of Influenza A Virus and Markers of Inflammation in the Human Parkinson's Disease Brain
TT Rohn, LW Catlin |
PloS one | 2011 |
An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity
A Patel, GV Toia, K Colletta, BD Bradaric, PM Carvey, B Hendey |
Experimental Neurology | 2011 |
IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
C Barcia, CM Ros, V Annese, A Gómez, F Ros-Bernal, D Aguado-Yera, ME Martínez-Pagán, V Pablos, E Fernandez-Villalba, MT Herrero |
Cell Death and Disease | 2011 |
Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
J Thévenet, RP Gobert, RH van Huijsduijnen, C Wiessner, YJ Sagot |
PloS one | 2011 |
Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection
S Stemberger, A Jamnig, N Stefanova, G Lepperdinger, M Reindl, GK Wenning |
PloS one | 2011 |
Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
M Hakimi, T Selvanantham, E Swinton, RF Padmore, Y Tong, G Kabbach, K Venderova, SE Girardin, DE Bulman, CR Scherzer, MJ LaVoie, D Gris, DS Park, JB Angel, J Shen, DJ Philpott, MG Schlossmacher |
Journal of Neural Transmission | 2011 |
The role of the MYD88-dependent pathway in MPTP-induced brain dopaminergic degeneration
J Drouin-Ouellet, C Gibrat, M Bousquet, F Calon, J Kriz, F Cicchetti |
Journal of Neuroinflammation | 2011 |
Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease
MT Armentero, A Pinna, S Ferré, JL Lanciego, CE Müller, R Franco |
Pharmacology & Therapeutics | 2011 |
Pathways towards an effective immunotherapy for Parkinson's disease
JA Hutter-Saunders, RL Mosley, HE Gendelman |
Expert Review of Neurotherapeutics | 2011 |
The executioners sing a new song: killer caspases activate microglia
JL Venero, MA Burguillos, P Brundin, B Joseph |
Cell Death and Differentiation | 2011 |
Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy
BD Bradaric, A Patel, JA Schneider, PM Carvey, B Hendey |
Journal of Neural Transmission - Parkinson's Disease and Dementia Section | 2011 |
FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice
WB 2nd, A Manaenko, T Lekic, Y Hasegawa, R Ostrowski, J Tang, JH Zhang |
Acta neurochirurgica. Supplement | 2011 |
Activated immune cells in Parkinson's disease.
Cao JJ, Li KS, Shen YQ |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 2011 |
Aspirin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity in primary midbrain cultures.
Wang F, Zhai H, Huang L, Li H, Xu Y, Qiao X, Sun S, Wu Y |
Journal of molecular neuroscience : MN | 2011 |
Kynurenines in Parkinson's disease: therapeutic perspectives.
Zádori D, Klivényi P, Toldi J, Fülöp F, Vécsei L |
Journal of neural transmission (Vienna, Austria : 1996) | 2011 |
Trafficking of immune cells in the central nervous system
Emma H. Wilson, Wolfgang Weninger, Chris Hunter |
Journal of Clinical Investigation | 2010 |
Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
V Sanchez-Guajardo, F Febbraro, D Kirik, M Romero-Ramos |
PloS one | 2010 |
Inflammation in neurodegenerative diseases
S Amor, F Puentes, D Baker, P der Valk |
Immunology | 2010 |
Mechanisms underlying inflammation in neurodegeneration
CK Glass, K Saijo, B Winner, MC Marchetto, FH Gage |
Cell | 2010 |
T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?
SH Appel, DR Beers, JS Henkel |
Trends in Immunology | 2010 |
Basic mechanisms of neurodegeneration: a critical update
KA Jellinger |
Journal of Cellular and Molecular Medicine | 2010 |
Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
S Cao, S Theodore, DG Standaert |
Molecular Neurodegeneration | 2010 |
Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy
L Qian, PM Flood, JS Hong |
Journal of Neural Transmission | 2010 |
POTENTIAL FUTURE NEUROPROTECTIVE THERAPIES FOR NEURODEGENERATIVE DISORDERS AND STROKE
R Tarawneh, JE Galvin |
Clinics in Geriatric Medicine | 2010 |
Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats
Z Yu, X Xu, Z Xiang, J Zhou, Z Zhang, C Hu, C He |
PloS one | 2010 |
Expression and regulation in the brain of the chemokine CCL27 gene locus
C Gunsolly, JD Nicholson, SJ Listwak, D Ledee, P Zelenka, D Verthelyi, S Chapoval, A Keegan, LH Tonelli |
Journal of Neuroimmunology | 2010 |
Pharmacological Therapy in Parkinson's Disease: Focus on Neuroprotection: Neuroprotection in Parkinson's Disease
ZT Kincses, L Vecsei |
CNS Neuroscience & Therapeutics | 2010 |
Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.
Davies NW, Guillemin G, Brew BJ |
International journal of tryptophan research : IJTR | 2010 |
Nitrated Alpha Synuclein Induced Alterations in Microglial Immunity is Regulated by CD4+ T Cell Subsets1
AD Reynolds, DK Stone, RL Mosley, HE Gendelman |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
CD 4+ T cells in the pathobiology of neurodegenerative disorders
X Huang, AD Reynolds, RL Mosley, HE Gendelman |
Journal of Neuroimmunology | 2009 |
Targeting neural precursors in the adult brain rescues injured dopamine neurons
A Androutsellis-Theotokis, MA Rueger, DM Park, H Mkhikian, E Korb, SW Poser, S Walbridge, J Munasinghe, AP Koretsky, RR Lonser, RD McKay |
Proceedings of the National Academy of Sciences | 2009 |
CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease?
K Rezai-Zadeh, D Gate, T Town |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 2009 |
Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease
A Ghosh, A Roy, J Matras, S Brahmachari, HE Gendelman, K Pahan |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2009 |
Immune activation in brain aging and neurodegeneration: too much or too little?
KM Lucin, T Wyss-Coray |
Neuron | 2009 |
Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
H Ilieva, M Polymenidou, DW Cleveland |
The Journal of Cell Biology | 2009 |
Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice
T Ishikawa, H Yamada, A Oyamada, F Goshima, Y Nishiyama, Y Yoshikai |
Journal of virology | 2009 |
Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain
SH Choi, S Aid, U Choi, F Bosetti |
The Pharmacogenomics Journal | 2009 |
The Blood Brain Barrier in Neurodegenerative Disease: A Rhetorical Perspective
PM Carvey, B Hendey, AJ Monahan |
Journal of Neurochemistry | 2009 |
Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells
AD Reynolds, DK Stone, RL Mosley, HE Gendelman |
Journal of Proteome Research | 2009 |
Heterogeneity of microglia and TNF signaling as determinants for neuronal death or survival
AD Kraft, CA McPherson, GJ Harry |
NeuroToxicology | 2009 |
Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention
MG Tansey, MS Goldberg |
Neurobiology of Disease | 2009 |
Neuroinflammation in Parkinson's disease
JK Lee, T Tran, MG Tansey |
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology | 2009 |
Recent advances in our understanding of neurodegeneration
KA Jellinger |
Journal of Neural Transmission | 2009 |
CD4+ T cells mediate cytotoxicity in neurodegenerative diseases
Stanley H. Appel |
Journal of Clinical Investigation | 2008 |