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Usage Information

Regulation of Aβ pathology by beclin 1: a protective role for autophagy?
Jin-A Lee, Fen-Biao Gao
Jin-A Lee, Fen-Biao Gao
Published May 22, 2008
Citation Information: J Clin Invest. 2008;118(6):2015-2018. https://doi.org/10.1172/JCI35662.
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Commentary

Regulation of Aβ pathology by beclin 1: a protective role for autophagy?

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Abstract

The amyloid β (Aβ) peptide is thought to be a major culprit in Alzheimer disease (AD), and its production and degradation have been intensely investigated. Nevertheless, it remains largely unknown how Aβ pathology is modulated by the autophagy pathway. The study by Pickford and colleagues in this issue of the JCI shows that beclin 1, a multifunctional protein that also plays an important role in the autophagy pathway, affects some aspects of Aβ pathology in aged but not young transgenic mice expressing amyloid precursor protein (APP) (see the related article beginning on page 2190). These findings further support the notion that modulation of autophagy, in this case through beclin 1, may represent a novel therapeutic strategy for AD.

Authors

Jin-A Lee, Fen-Biao Gao

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 294 20
PDF 77 25
Figure 138 2
Citation downloads 73 0
Totals 582 47
Total Views 629
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