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Citations to this article

A skewed view of X chromosome inactivation
Jakub Minks, … , Wendy P. Robinson, Carolyn J. Brown
Jakub Minks, … , Wendy P. Robinson, Carolyn J. Brown
Published December 20, 2007
Citation Information: J Clin Invest. 2008;118(1):20-23. https://doi.org/10.1172/JCI34470.
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Commentary Article has an altmetric score of 6

A skewed view of X chromosome inactivation

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Abstract

X chromosome inactivation involves a random choice to silence either X chromosome early in mammalian female development. Once silenced the inactive X is stably inherited through subsequent somatic cell divisions, and thus, females are generally mosaics, having a mixture of cells with one or the other parental X active. While in most females the number of cells with either X being active is roughly equal, skewing of X chromosome inactivation is observed in a percentage of women. In this issue of the JCI, Bolduc and colleagues address whether skewing of X chromosome inactivation in humans is influenced by an X-linked locus that can alter this initial random inactivation (see the related article beginning on page 333). Their data indicate that most of the skewing observed in humans results from secondary events rather than being due to an inherited tendency to inactivate a particular X chromosome.

Authors

Jakub Minks, Wendy P. Robinson, Carolyn J. Brown

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 Total
Citations: 1 4 2 8 6 4 4 4 4 1 1 4 4 2 1 2 52
Citation information
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Citations to this article (52)

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