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Usage Information

Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch
Marlene Rabinovitch
Published July 1, 2008
Citation Information: J Clin Invest. 2008;118(7):2372-2379. https://doi.org/10.1172/JCI33452.
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Science in Medicine Article has an altmetric score of 3

Molecular pathogenesis of pulmonary arterial hypertension

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Abstract

Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current treatments including i.v. prostacyclin. This review will address the cellular and molecular processes implicated in clinical, genetic, and experimental studies as underlying the pulmonary vascular abnormalities associated with PAH. Emerging treatments are aimed at inducing apoptosis of abnormal vascular cells that obstruct blood flow and at promoting regeneration of “lost” distal vasculature.

Authors

Marlene Rabinovitch

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