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The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice

Yuri Kim, … , Rhonda Bassel-Duby, Eric N. Olson

Yuri Kim, … , Rhonda Bassel-Duby, Eric N. Olson

Published December 13, 2007
Citation Information: J Clin Invest. 2008;118(1):124-132. https://doi.org/10.1172/JCI33255.

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Citations to this article (131)

Title and authors	Publication	Year
Temporal Transcriptomic Analysis of Periodontal Disease Progression and Its Molecular Links to Systemic Diseases Nantakeeratipat T, Fujihara C, Takedachi M	International Journal of Molecular Sciences	2025
Resveratrol-Based Liposomes Improve Cardiac Remodeling Induced by Isoproterenol Partially by Modulating MEF2, Cytochrome C and S100A1 Expression. Alhusaini AM, Alghibiwi HK, Sarawi WS, Alsaab JS, Alshehri SM, Alqahtani QH, Alshanwani AR, Aljassas EA, Alsultan EN, Hasan IH	Dose-response : a publication of International Hormesis Society	2024
The Molecular and Biological Function of MEF2D in Leukemia. Zhang P, Lu R	Advances in experimental medicine and biology	2024
Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis Gönczi M, Teixeira JM, Barrera-Vilarmau S, Mediani L, Antoniani F, Nagy TM, Fehér K, Ráduly Z, Ambrus V, Tőzsér J, Barta E, Kövér KE, Csernoch L, Carra S, Fuxreiter M	Nature Communications	2023
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia Chang N, Feng J, Liao P, Hu Y, Li M, He Y, Li Y	Translational cancer research	2023
Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact. Kiessling M, Djalinac N, Voglhuber J, Ljubojevic-Holzer S	Biomedicines	2023
A family with brachydactyly mental retardation syndrome with a missense variant in HDAC4 Takeyari S, Yamamoto K, Fujiwara M, Ohata Y, Kitaoka T, Kubota T, Nagata M, Ishihara Y, Miyashita Y, Asano Y, Ozono K	Clinical Pediatric Endocrinology	2023
The MEF2A transcription factor interactome in cardiomyocytes. Moustafa A, Hashemi S, Brar G, Grigull J, Ng SHS, Williams D, Schmitt-Ulms G, McDermott JC	Cell Death and Disease	2023
CRISPR activation and interference as investigative tools in the cardiovascular system Carroll MS, Giacca M	The International Journal of Biochemistry & Cell Biology	2023
The significance of ERK5 catalytic-independent functions in disease pathways Le NT	Frontiers in Cell and Developmental Biology	2023
HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction Zhu C, Piao Z, Jin L	Orphanet Journal of Rare Diseases	2023
Aging, adaptation and maladaptation Lissek T		2023
Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice Qu JH, Tarasov KV, Tarasova YS, Chakir K, Lakatta EG		2023
Loss of m6A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression Y Han, T Du, S Guo, L Wang, G Dai, T Long, T Xu, X Zhuang, C Liu, S Li, D Zhang, X Liao, Y Dong, K Lui, X Tan, S Lin, Y Chen, Z Huang	Frontiers in Cardiovascular Medicine	2022
Angiotensin II Mediates Cardiomyocyte Hypertrophy in Atrial Cardiomyopathy via Epigenetic Transcriptional Regulation Zheng L, Wang J, Zhang R, Zhang Y, Geng J, Cao L, Zhao X, Geng J, Du X, Hu Y, Cong H	Computational and mathematical methods in medicine	2022
Non-Coding RNAs in the Therapeutic Landscape of Pathological Cardiac Hypertrophy Silva J, da Costa Martins PA	Cells	2022
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabič Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M	Genes & development	2022
Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy Feng Y, Cai L, Hong W, Zhang C, Tan N, Wang M, Wang C, Liu F, Wang X, Ma J, Gao C, Kumar M, Mo Y, Geng Q, Luo C, Lin Y, Chen H, Wang SY, Watson MJ, Jegga AG, Pedersen RA, Fu JD, Wang ZV, Fan GC, Sadayappan S, Wang Y, Pauklin S, Huang F, Huang W, Jiang L	Circulation	2022
Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy. Martinez EC, Li J, Ataam JA, Tokarski K, Thakur H, Karakikes I, Dodge-Kafka K, Kapiloff MS	Gene Therapy	2022
Protections of transcription factor BACH2 and natural product myricetin against pathological cardiac hypertrophy and dysfunction. Jiang X, Cao M, Wu J, Wang X, Zhang G, Yang C, Gao P, Zou Y	Frontiers in physiology	2022
Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia Pingul BY, Huang H, Chen Q, Alikarami F, Zhang Z, Qi J, Bernt KM, Berger SL, Cao Z, Shi J	iScience	2022
Variable paralog expression underlies phenotype variation Bailon-Zambrano R, Sucharov J, Mumme-Monheit A, Murry M, Stenzel A, Pulvino AT, Mitchell JM, Colborn KL, Nichols JT	eLife	2022
Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease Demydenko K, Ekhteraei-Tousi S, Roderick HL	Philosophical Transactions of the Royal Society B: Biological Sciences	2022
Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion Zhang M, Zhang H, Li Z, Bai L, Wang Q, Li J, Jiang M, Xue Q, Cheng N, Zhang W, Mao D, Chen Z, Huang J, Meng G, Chen Z, Chen SJ	Blood	2022
Quercetin alleviates diastolic dysfunction and suppresses adverse pro-hypertrophic signaling in diabetic rats Bartosova L, Horvath C, Galis P, Ferenczyova K, Kalocayova B, Szobi A, Duris-Adameova A, Bartekova M, Rajtik T	Frontiers in Endocrinology	2022
MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program YW Lu, N Martino, BD Gerlach, JM Lamar, PA Vincent, AP Adam, JJ Schwarz	Arteriosclerosis, thrombosis, and vascular biology	2021
The MEK5/ERK5 Pathway in Health and Disease R Paudel, L Fusi, M Schmidt	International journal of molecular sciences	2021
Transcriptional Regulation of Postnatal Cardiomyocyte Maturation and Regeneration SL Padula, N Velayutham, KE Yutzey	International journal of molecular sciences	2021
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration A Raso, E Dirkx, V Sampaio-Pinto, H el Azzouzi, RJ Cubero, DW Sorensen, L Ottaviani, S Olieslagers, MM Huibers, R de Weger, S Siddiqi, S Moimas, C Torrini, L Zentillin, L Braga, DS Nascimento, PA da Costa Martins, JH van Berlo, S Zacchigna, M Giacca, LJ Windt	Nature Communications	2021
Mef2d sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity Eros Di Giorgio, Liqing Wang, Yan Xiong, Tatiana Akimova, Lanette M. Christensen, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Tricia R. Bhatti, Ulf H. Beier, Wayne W. Hancock	Journal of Clinical Investigation	2020
MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure AH Pereira, AC Cardoso, SR Consonni, RR Oliveira, A Saito, ML Vaggione, JR Matos-Souza, MF Carazzolle, A Gonçalves, JL Fernandes, GC Ribeiro, MM Lopes, JD Molkentin, KG Franchini	EBioMedicine	2020
Genomic Binding Patterns of Forkhead Box Protein O1 Reveal its Unique Role in Cardiac Hypertrophy J Pfleger, RC Coleman, J Ibetti, R Roy, ID Kyriazis, E Gao, K Drosatos, WJ Koch	Circulation	2020
Loss of Mef2D function enhances TLR induced IL-10 production in macrophages MJ Pattison, RJ Naik, KM Reyskens, JS Arthur	Bioscience Reports	2020
CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure S Batkai, C Genschel, J Viereck, S Rump, C Bär, T Borchert, D Traxler, M Riesenhuber, A Spannbauer, D Lukovic, K Zlabinger, E Hašimbegović, J Winkler, R Garamvölgyi, S Neitzel, M Gyöngyösi, T Thum	European Heart Journal	2020
MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury X Xia, CY Yu, M Bian, CB Sun, B Tanasa, KC Chang, DM Bruffett, H Thakur, SH Shah, C Knasel, EG Cameron, MS Kapiloff, JL Goldberg, TC Badea	PloS one	2020
Nuclear receptor corepressor 1 represses cardiac hypertrophy C Li, XN Sun, BY Chen, MR Zeng, LJ Du, T Liu, HH Gu, Y Liu, YL Li, LJ Zhou, XJ Zheng, YY Zhang, WC Zhang, Y Liu, C Shi, S Shao, XR Shi, Y Yi, X Liu, J Wang, J Auwerx, ZV Wang, F Jia, RG Li, SZ Duan	EMBO Molecular Medicine	2019
MEF2 and the Right Ventricle: From Development to Disease KR Clapham, I Singh, IS Capuano, S Rajagopal, HJ Chun	Frontiers in Cardiovascular Medicine	2019
The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4 ZH Jebessa, KD Shanmukha, M Dewenter, LH Lehmann, C Xu, F Schreiter, D Siede, XM Gong, BC Worst, G Federico, SW Sauer, T Fischer, L Wechselberger, OJ Müller, S Sossalla, C Dieterich, P Most, HJ Gröne, C Moro, M Oberer, G Haemmerle, HA Katus, J Tyedmers, J Backs		2019
MEF-2 isoforms’ (A-D) roles in development and tumorigenesis K Madugula, R Mulherkar, ZK Khan, DG Chigbu, D Patel, EW Harhaj, P Jain	Oncotarget	2019
Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice JA Mohawk, KH Cox, M Sato, SH Yoo, M Yanagisawa, EN Olson, JS Takahashi	The Journal of neuroscience : the official journal of the Society for Neuroscience	2019
mAKAPβ signalosomes – A nodal regulator of gene transcription associated with pathological cardiac remodeling K Dodge-Kafka, M Gildart, K Tokarski, MS Kapiloff	Cellular Signalling	2019
Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure DF Dai, Y Liu, N Basisty, P Karunadharma, SG Dastidar, YA Chiao, T Chen, RP Beyer, MT Chin, M Maccoss, AR Spada, PS Rabinovitch	GeroScience	2019
Regulation of cardiomyocyte maturation during critical perinatal window S Kannan, C Kwon	The Journal of Physiology	2019
Waking the sleeping dragon: gene expression profiling reveals adaptive strategies of the hibernating reptile Pogona vitticeps A Capraro, D OMeally, SA Waters, HR Patel, A Georges, PD Waters	BMC Genomics	2019
Cardiac function modulation depends on the A‐kinase anchoring protein complex YR Zhu, XX Jiang, Y Zheng, J Xiong, D Wei, DM Zhang	Journal of Cellular and Molecular Medicine	2019
Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function A Wnorowski, A Sharma, H Chen, H Wu, NY Shao, N Sayed, C Liu, S Countryman, LS Stodieck, KH Rubins, SM Wu, PH Lee, JC Wu	Stem Cell Reports	2019
Inflammation leads through PGE/EP 3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes AD Tóth, R Schell, M Lévay, C Vettel, P Theis, C Haslinger, F Alban, S Werhahn, L Frischbier, J KrebsHaupenthal, D Thomas, HJ Gröne, M Avkiran, HA Katus, T Wieland, J Backs	EMBO Molecular Medicine	2018
Morphology regulation in vascular endothelial cells K Tsuji-Tamura, M Ogawa	Inflammation and Regeneration	2018
Network-based predictions of in vivo cardiac hypertrophy DU Frank, MD Sutcliffe, JJ Saucerman	Journal of Molecular and Cellular Cardiology	2018
Physiological Responses to Swimming-Induced Exercise in the Adult Zebrafish Regenerating Heart M Rovira, DM Borràs, IJ Marques, C Puig, JV Planas	Frontiers in physiology	2018
Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure S Nomura, M Satoh, T Fujita, T Higo, T Sumida, T Ko, T Yamaguchi, T Tobita, AT Naito, M Ito, K Fujita, M Harada, H Toko, Y Kobayashi, K Ito, E Takimoto, H Akazawa, H Morita, H Aburatani, I Komuro	Nature Communications	2018
Muscle A-kinase–anchoring protein-β–bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D J Li, SA Paris, H Thakur, MS Kapiloff, KL Dodge-Kafka	The Journal of biological chemistry	2018
Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure Duane Hall, Jessica Ponce, Biyi Chen, Kathryn Spitler, Adrianne Alexia, Gavin Oudit, Long-sheng Song, Chad Grueter	JCI Insight	2017
Reversal of pathological cardiac hypertrophy via the MEF2-co-regulator interface Jian Qin Wei, Shaurya Joshi, Svetlana Speransky, Christopher Crowley, Nimanthi Jayathilaka, Xiao Lei, Yongqing Wu, David Gai, Sumit Jain, Michael Hoosien, Yan Gao, Lin Chen, Nanette H. Bishopric	JCI Insight	2017
Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling W Liu, A Ruiz-Velasco, S Wang, S Khan, M Zi, A Jungmann, MD Camacho-Muñoz, J Guo, G Du, L Xie, D Oceandy, A Nicolaou, G Galli, OJ Müller, EJ Cartwright, Y Ji, X Wang	Nature Communications	2017
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway LH Lehmann, ZH Jebessa, MM Kreusser, A Horsch, T He, M Kronlage, M Dewenter, V Sramek, U Oehl, J Krebs-Haupenthal, AH von der Lieth, A Schmidt, Q Sun, J Ritterhoff, D Finke, M Völkers, A Jungmann, SW Sauer, C Thiel, A Nickel, M Kohlhaas, M Schäfer, C Sticht, C Maack, N Gretz, M Wagner, A El-Armouche, LS Maier, JE Londoño, B Meder, M Freichel, HJ Gröne, P Most, OJ Müller, S Herzig, EE Furlong, HA Katus, J Backs	Nature Medicine	2017
Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers SW Tobin, S Hashemi, K Dadson, S Turdi, K Ebrahimian, J Zhao, G Sweeney, J Grigull, JC McDermott	Scientific Reports	2017
Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart W Eldik, B Adel, J Monshouwer-Kloots, D Salvatori, S Maas, I der Made, EE Creemers, D Frank, N Frey, N Boontje, J der Velden, P Steendijk, C Mummery, R Passier, A Beqqali, V Lionetti	PloS one	2017
Targeting myocyte-specific enhancer factor 2D contributes to the suppression of cardiac hypertrophic growth by miR-92b-3p in mice ZQ Hu, JF Luo, XJ Yu, JN Zhu, L Huang, J Yang, YH Fu, T Li, YM Xue, YQ Feng, ZX Shan	Oncotarget	2017
Long-term consequences of disrupting adenosine signaling during embryonic development SA Rivkees, CC Wendler	Molecular Aspects of Medicine	2017
MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress S Nagar, SM Noveral, D Trudler, KM Lopez, SR McKercher, X Han, JR Yates, JC Piña-Crespo, N Nakanishi, T Satoh, S Okamoto, SA Lipton	Proceedings of the National Academy of Sciences	2017
Antagonistic regulation of cell-cycle and differentiation gene programs in neonatal cardiomyocytes by homologous MEF2 transcription factors CA Desjardins, FJ Naya	The Journal of biological chemistry	2017
Poly(A) tail length regulates PABPC1 expression to tune translation in the heart S Chorghade, J Seimetz, R Emmons, J Yang, SM Bresson, MD Lisio, G Parise, NK Conrad, A Kalsotra	eLife	2017
Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency S Nagar, D Trudler, SR McKercher, J Piña-Crespo, N Nakanishi, SI Okamoto, SA Lipton	Investigative ophthalmology & visual science	2017
Protein kinase D2: a versatile player in cancer biology N Azoitei, M Cobbaut, A Becher, JV Lint, T Seufferlein	Oncogene	2017
How cardiomyocytes sense pathophysiological stresses for cardiac remodeling ZK Haque, DZ Wang	Cellular and Molecular Life Sciences	2016
Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy CM Tang, F Liu, JN Zhu, YH Fu, QX Lin, CY Deng, ZQ Hu, H Yang, XL Zheng, JD Cheng, SL Wu, ZX Shan	Scientific Reports	2016
The Function of the MEF2 Family of Transcription Factors in Cardiac Development, Cardiogenomics, and Direct Reprogramming C Desjardins, F Naya	Journal of Cardiovascular Development and Disease	2016
Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment JW Wassenaar, R Gaetani, JJ Garcia, RL Braden, CG Luo, D Huang, AN DeMaria, JH Omens, KL Christman	Journal of the American College of Cardiology	2016
ERK5 and Cell Proliferation: Nuclear Localization Is What Matters N Gomez, T Erazo, JM Lizcano	Frontiers in Cell and Developmental Biology	2016
In Utero Caffeine Exposure Induces Transgenerational Effects on the Adult Heart X Fang, RR Poulsen, SA Rivkees, CC Wendler	Scientific Reports	2016
miR-410 and miR-495 Are Dynamically Regulated in Diverse Cardiomyopathies and Their Inhibition Attenuates Pathological Hypertrophy AL Clark, S Maruyama, S Sano, A Accorsi, M Girgenrath, K Walsh, FJ Naya, M Karmazyn	PloS one	2016
Readers, Writers, and Erasers: Chromatin as the Whiteboard of Heart Disease TG Gillette, JA Hill	Circulation research	2015
Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart M Cardona, JA López, A Serafín, A Rongvaux, J Inserte, D García-Dorado, R Flavell, M Llovera, X Cañas, J Vázquez, D Sanchis, GC Fan	PloS one	2015
Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers S Hashemi, J Salma, S Wales, JC McDermott	Cell Death Discovery	2015
mAKAP—A Master Scaffold for Cardiac Remodeling: CL Passariello, J Li, K Dodge-Kafka, MS Kapiloff	Journal of Cardiovascular Pharmacology	2015
MEF2D Drives Photoreceptor Development through a Genome-wide Competition for Tissue-Specific Enhancers MM Andzelm, TJ Cherry, DA Harmin, AC Boeke, C Lee, M Hemberg, B Pawlyk, AN Malik, SW Flavell, MA Sandberg, E Raviola, ME Greenberg	Neuron	2015
Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy KR Johnson, J Nicodemus-Johnson, MJ Spindler, GK Carnegie, S Gupta	PloS one	2015
MEF2D Deficiency in Neonatal Cardiomyocytes Triggers Cell Cycle Re-entry and Programmed Cell Death in Vitro NL Estrella, AL Clark, CA Desjardins, SE Nocco, FJ Naya	The Journal of biological chemistry	2015
A p38 MAPK regulated MEF2:β-catenin interaction enhances canonical Wnt signalling S Ehyai, MG Dionyssiou, JW Gordon, D Williams, KW Siu, JC McDermott	Molecular and cellular biology	2015
Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo SE Latchney, Y Jiang, DP Petrik, AJ Eisch, J Hsieh	The FASEB Journal	2015
Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells M Di-Luoffo, C Daems, F Bergeron, JJ Tremblay	Biology of reproduction	2015
MEF2 transcription factors: developmental regulators and emerging cancer genes Pon JR, Marra MA	Oncotarget	2015
The Scaffold Protein Muscle A-Kinase Anchoring Protein Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure MD Kritzer, J Li, CL Passariello, M Gayanilo, H Thakur, J Dayan, K Dodge-Kafka, MS Kapiloff	Circulation. Heart failure	2014
CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury M Weinreuter, MM Kreusser, J Beckendorf, FC Schreiter, F Leuschner, LH Lehmann, KP Hofmann, JS Rostosky, N Diemert, C Xu, HC Volz, A Jungmann, A Nickel, C Sticht, N Gretz, C Maack, MD Schneider, HJ Grone, OJ Muller, HA Katus, J Backs	EMBO Molecular Medicine	2014
Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling LH Lehmann, JS Rostosky, SJ Buss, MM Kreusser, J Krebs, W Mier, F Enseleit, K Spiger, SE Hardt, T Wieland, M Haass, TF Luscher, MD Schneider, R Parlato, HJ Grone, U Haberkorn, M Yanagisawa, HA Katus, J Backs	Proceedings of the National Academy of Sciences	2014
Cardiac CaM Kinase II Genes and Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy MM Kreusser, LH Lehmann, S Keranov, MO Hoting, U Oehl, M Kohlhaas, JC Reil, K Neumann, MD Schneider, JA Hill, D Dobrev, C Maack, LS Maier, HJ Grone, HA Katus, EN Olson, J Backs	Circulation	2014
Requirement of MEF2A, C, and D for skeletal muscle regeneration N Liu, BR Nelson, S Bezprozvannaya, JM Shelton, JA Richardson, R Bassel-Duby, EN Olson	Proceedings of the National Academy of Sciences	2014
Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling S Wales, S Hashemi, A Blais, JC McDermott	Nucleic Acids Research	2014
ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage SF Chan, S Sances, LM Brill, S Okamoto, R Zaidi, SR McKercher, MW Akhtar, N Nakanishi, SA Lipton	The Journal of neuroscience : the official journal of the Society for Neuroscience	2014
Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac HypertrophyNovelty and Significance DS Jiang, Y Liu, H Zhou, Y Zhang, XD Zhang, XF Zhang, K Chen, L Gao, J Peng, H Gong, Y Chen, Q Yang, PP Liu, GC Fan, Y Zou, H Li	Hypertension	2014
Comparative analysis reveals distinct and overlapping functions of Mef2c and Mef2d during cardiogenesis in Xenopus laevis Y Guo, SJ Kühl, AS Pfister, W Cizelsky, S Denk, L Beer-Molz, M Kühl	PloS one	2014
Steroid Receptor Coactivator-2 Is a Dual Regulator of Cardiac Transcription Factor Function EL Reineke, A Benham, B Soibam, E Stashi, H Taegtmeyer, ML Entman, RJ Schwartz, BW O'Malley	The Journal of biological chemistry	2014
MEF2 Is Restricted to the Male Gonad and Regulates Expression of the Orphan Nuclear Receptor NR4A1 C Daems, LJ Martin, C Brousseau, JJ Tremblay	Molecular Endocrinology	2014
Histone deacetylase signaling in cardioprotection LH Lehmann, BC Worst, DA Stanmore, J Backs	Cellular and Molecular Life Sciences	2013
Intermedin suppresses pressure overload cardiac hypertrophy through activation of autophagy H Chen, X Wang, M Tong, D Wu, S Wu, J Chen, X Wang, X Wang, Y Kang, H Tang, C Tang, W Jiang	PloS one	2013
Role of Interferon Regulatory Factor 4 in the Regulation of Pathological Cardiac Hypertrophy DS Jiang, ZY Bian, Y Zhang, SM Zhang, Y Liu, R Zhang, Y Chen, Q Yang, XD Zhang, GC Fan, H Li	Hypertension	2013
Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity T Zang, MA Maksimova, CW Cowan, R Bassel-Duby, EN Olson, KM Huber	Molecular and Cellular Neuroscience	2013
A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart J Ye, M Llorian, M Cardona, A Rongvaux, RS Moubarak, JX Comella, R Bassel-Duby, RA Flavell, EN Olson, CW Smith, D Sanchis	Journal of cell science	2013
Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics P Teekakirikul, RF Padera, JG Seidman, CE Seidman	The Journal of Cell Biology	2012
The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth FM Drawnel, CR Archer, HL Roderick	British Journal of Pharmacology	2012
In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal Survival MW Akhtar, MS Kim, M Adachi, MJ Morris, X Qi, JA Richardson, R Bassel-Duby, EN Olson, ET Kavalali, LM Monteggia	PloS one	2012
Regulation of MEF2 Transcriptional Activity by Calcineurin/mAKAP Complexes J Li, MA Vargas, MS Kapiloff, KL Dodge-Kafka	Experimental Cell Research	2012
Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule D Petrik, Y Jiang, SG Birnbaum, CM Powell, MS Kim, J Hsieh, AJ Eisch	The FASEB Journal	2012
Direct Regulation of Complex I by Mitochondrial MEF2D and Its Role in Mouse Model and Human Specimens of Parkinson’s Disease Hua She, Qian Yang, Kennie Shepherd, Yoland Smith, Gary Miller, Claudia Testa, Zixu Mao	Journal of Clinical Investigation	2011
Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4 J Backs, BC Worst, LH Lehmann, DM Patrick, Z Jebessa, MM Kreusser, Q Sun, L Chen, C Heft, HA Katus, EN Olson	The Journal of Cell Biology	2011
Oxidation of CaMKII determines cardiotoxic effects of aldosterone BJ He, ML Joiner, MV Singh, ED Luczak, PD Swaminathan, OM Koval, W Kutschke, C Allamargot, J Yang, X Guan, K Zimmerman, IM Grumbach, RM Weiss, DR Spitz, CD Sigmund, WM Blankesteijn, S Heymans, PJ Mohler, ME Anderson	Nature Medicine	2011
The Mef2A Transcription Factor Coordinately Regulates a Costamere Gene Program in Cardiac Muscle* EP Ewen, CM Snyder, M Wilson, D Desjardins, FJ Naya	The Journal of biological chemistry	2011
Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy G Majumdar, RJ Rooney, IM Johnson, R Raghow	Physiological genomics	2011
Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish JD Wythe, MJ Jurynec, LD Urness, CA Jones, MK Sabeh, AA Werdich, M Sato, HJ Yost, DJ Grunwald, CA MacRae, DY Li	Disease models & mechanisms	2011
Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly J He, J Ye, Y Cai, C Riquelme, JO Liu, X Liu, A Han, L Chen	Nucleic Acids Research	2011
Sex-dimorphism in Cardiac Nutrigenomics: effect of Trans fat and/or Monosodium Glutamate consumption KS Collison, MZ Zaidi, Z Maqbool, SM Saleh, A Inglis, NJ Makhoul, R Bakheet, M Shoukri, FA Al-Mohanna	BMC Genomics	2011
Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress DF Dai, EJ Hsieh, Y Liu, T Chen, RP Beyer, MT Chin, MJ MacCoss, PS Rabinovitch	Cardiovascular Research	2011
Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth I Kehat, J Davis, M Tiburcy, F Accornero, MK Saba-El-Leil, M Maillet, AJ York, JN Lorenz, WH Zimmermann, S Meloche, JD Molkentin	Circulation research	2011
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy T Konno, D Chen, L Wang, H Wakimoto, P Teekakirikul, M Nayor, M Kawana, S Eminaga, JM Gorham, K Pandya, O Smithies, FJ Naya, EN Olson, JG Seidman, CE Seidman	Proceedings of the National Academy of Sciences	2010
Bone marrow support of the heart in pressure overload is lost with aging NA Sopko, BA Turturice, ME Becker, CR Brown, F Dong, ZB Popović, MS Penn	PloS one	2010
Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart TE Kimura, J Jin, M Zi, S Prehar, W Liu, D Oceandy, J Abe, L Neyses, AH Weston, EJ Cartwright, X Wang	Circulation research	2010
The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload Y Liu, M Yu, L Wu, MT Chin	American journal of physiology. Heart and circulatory physiology	2010
Active Wnt signaling in response to cardiac injury MI Oerlemans, MJ Goumans, B Middelaar, H Clevers, PA Doevendans, JP Sluijter	Basic Research in Cardiology	2010
Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment Y Wu, R Dey, A Han, N Jayathilaka, M Philips, J Ye, L Chen	Journal of Molecular Biology	2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice AH Pereira, CF Clemente, AC Cardoso, TH Theizen, SA Rocco, CC Judice, MC Guido, VD Pascoal, I Lopes-Cendes, JR Souza, KG Franchini	PloS one	2009
The many roles of histone deacetylases in development and physiology: implications for disease and therapy M Haberland, RL Montgomery, EN Olson	Nature reviews. Genetics	2009
The isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload J Backs, T Backs, S Neef, MM Kreusser, LH Lehmann, DM Patrick, CE Grueter, X Qi, JA Richardson, JA Hill, HA Katus, R Bassel-Duby, LS Maier, EN Olson	Proceedings of the National Academy of Sciences	2009
Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart Failure ME Putt, S Hannenhalli, Y Lu, P Haines, HR Chandrupatla, EE Morrisey, KB Margulies, TP Cappola	Circulation. Cardiovascular genetics	2009
Maintenance of cardiac energy metabolism by histone deacetylase 3 Rusty L. Montgomery1, Matthew J. Potthoff1, Michael Haberland1, Xiaoxia Qi1, Satoshi Matsuzaki2, Kenneth M. Humphries2, James A. Richardson3, Rhonda Bassel-Duby1, and Eric N. Olson1	Journal of Clinical Investigation	2008
The rationale for cardiomyocyte resuscitation in myocardial salvage GW Dorn, A Diwan	Journal of Molecular Medicine	2008
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart N Liu, S Bezprozvannaya, AH Williams, X Qi, JA Richardson, R Bassel-Duby, EN Olson	Genes & development	2008
Requirement of protein kinase D1 for pathological cardiac remodeling J Fielitz, MS Kim, JM Shelton, X Qi, JA Hill, JA Richardson, R Bassel-Duby, EN Olson	Proceedings of the National Academy of Sciences	2008
Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure DR Fermin, A Barac, S Lee, SP Polster, S Hannenhalli, TL Bergemann, S Grindle, DB Dyke, F Pagani, LW Miller, S Tan, C dos Remedios, TP Cappola, KB Margulies, JL Hall	Circulation. Cardiovascular genetics	2008
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133 N Liu, AH Williams, Y Kim, J McAnally, S Bezprozvannaya, LB Sutherland, JA Richardson, R Bassel-Duby, EN Olson	Proceedings of the National Academy of Sciences	2007

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