Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension
Georg Hansmann, … , Nicholas W. Morrell, Marlene Rabinovitch
Georg Hansmann, … , Nicholas W. Morrell, Marlene Rabinovitch
Published April 1, 2008
Citation Information: J Clin Invest. 2008;118(5):1846-1857. https://doi.org/10.1172/JCI32503.
View: Text | PDF
Research Article Cardiology Article has an altmetric score of 9

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

  • Text
  • PDF
Abstract

Loss-of-function mutations in bone morphogenetic protein receptor II (BMP-RII) are linked to pulmonary arterial hypertension (PAH); the ligand for BMP-RII, BMP-2, is a negative regulator of SMC growth. Here, we report an interplay between PPARγ and its transcriptional target apoE downstream of BMP-2 signaling. BMP-2/BMP-RII signaling prevented PDGF-BB–induced proliferation of human and murine pulmonary artery SMCs (PASMCs) by decreasing nuclear phospho-ERK and inducing DNA binding of PPARγ that is independent of Smad1/5/8 phosphorylation. Both BMP-2 and a PPARγ agonist stimulated production and secretion of apoE by SMCs. Using a variety of methods, including short hairpin RNAi in human PASMCs, PAH patient–derived BMP-RII mutant PASMCs, a PPARγ antagonist, and PASMCs isolated from PPARγ- and apoE-deficient mice, we demonstrated that the antiproliferative effect of BMP-2 was BMP-RII, PPARγ, and apoE dependent. Furthermore, we created mice with targeted deletion of PPARγ in SMCs and showed that they spontaneously developed PAH, as indicated by elevated RV systolic pressure, RV hypertrophy, and increased muscularization of the distal pulmonary arteries. Thus, PPARγ-mediated events could protect against PAH, and PPARγ agonists may reverse PAH in patients with or without BMP-RII dysfunction.

Authors

Georg Hansmann, Vinicio A. de Jesus Perez, Tero-Pekka Alastalo, Cristina M. Alvira, Christophe Guignabert, Janine M. Bekker, Stefan Schellong, Takashi Urashima, Lingli Wang, Nicholas W. Morrell, Marlene Rabinovitch

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 3 13 7 7 10 15 14 15 13 18 14 10 21 17 21 15 10 3 226
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (226)

Title and authors Publication Year
The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway
Jin Y, Mao F, Wang X, Zhang J, Gao Y, Fan Y
Scientific Reports 2025
Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension
Harper RL, Zhou X, Marciano DP, Cao A, Wang L, Chen G, Adil MS, Zhou W, Maguire P, Deivanayagam S, Yu Q, Viswanathan V, Yang D, Martin M, Isobe S, Otsuki S, Burgess J, Inglis A, Kelley D, del Rosario PA, Hsi A, Haddad F, Zamanian RT, Boehm M, Snyder MP, Rabinovitch M
Respiratory Research 2025
Novel Therapies for Right Ventricular Failure.
Das BB
Current cardiology reports 2025
BMPR2 mutation and clinical response to imatinib in a case of heritable pulmonary arterial hypertension
Kumar S, Biswas L, Pushkaran AC, Kumar RK
Pulmonary circulation 2024
Animals in Respiratory Research.
Fröhlich E
International journal of molecular sciences 2024
IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension
Ishibashi T, Inagaki T, Okazawa M, Yamagishi A, Ohta-Ogo K, Asano R, Masaki T, Kotani Y, Ding X, Chikaishi-Kirino T, Maedera N, Shirai M, Hatakeyama K, Kubota Y, Kishimoto T, Nakaoka Y
Proceedings of the National Academy of Sciences 2024
BMPR2 Loss Activates AKT by Disrupting DLL4/NOTCH1 and PPARγ Signaling in Pulmonary Arterial Hypertension
Awad KS, Wang S, Dougherty EJ, Keshavarz A, Demirkale CY, Yu ZX, Miller L, Elinoff JM, Danner RL
International journal of molecular sciences 2024
Disruption of DLL4/NOTCH1 Causes Dysregulated PPARγ/AKT Signaling in Pulmonary Arterial Hypertension
Awad KS, Wang S, Dougherty EJ, Keshavarz A, Demirkale CY, Yu ZX, Miller L, Elinoff JM, Danner RL
2024
BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension
Shen H, Gao Y, Ge D, Tan M, Yin Q, Wei TY, He F, Lee TY, Li Z, Chen Y, Yang Q, Liu Z, Li X, Chen Z, Yang Y, Zhang Z, Thistlethwaite PA, Wang J, Malhotra A, Yuan JX, Shyy JY, Gong K
Circulation 2024
Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression
Legchenko E, Chouvarine P, Qadri F, Specker E, Nazaré M, Wesolowski R, Matthes S, Bader M, Hansmann G
JACC: Basic to Translational Science 2024
Empagliflozin Attenuates Pulmonary Arterial Remodeling Through Peroxisome Proliferator-Activated Receptor Gamma Activation
Lai YJ, Yeh YH, Huang YL, De Almeida C, Chang GJ, Chen WJ, Hsu HH
ACS Pharmacology & Translational Science 2024
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases.
Wen Y, Zheng Y, Hua S, Li T, Bi X, Lu Q, Li M, Sun S
Current allergy and asthma reports 2024
NCAM1 modulates the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary hypertension
Chen Y, Liu N, Yang Y, Yang L, Li Y, Qiao Z, Zhang Y, Li A, Xiang R, Wen L, Huang W
Respiratory Research 2024
Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes
You Q, Song H, Zhu Z, Wang J, Wang R, Du M, Fu Y, Yuan J, Tan R
Cellular & Molecular Biology Letters 2024
Extrapulmonary manifestations of pulmonary arterial hypertension
Singh N, Al-Naamani N, Brown MB, Long GM, Thenappan T, Umar S, Ventetuolo CE, Lahm T
Expert review of respiratory medicine 2024
High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension
Shinohara T, Moonen JR, Chun YH, Lee-Yow YC, Okamura K, Szafron JM, Kaplan J, Cao A, Wang L, Guntur D, Taylor S, Isobe S, Dong M, Yang W, Guo K, Franco BD, Pacharinsak C, Pisani LJ, Saitoh S, Mitani Y, Marsden AL, Engreitz JM, Körbelin J, Rabinovitch M
Arteriosclerosis, thrombosis, and vascular biology 2024
Transcription factors in the pathogenesis of pulmonary arterial hypertension—Current knowledge and therapeutic potential
Körbelin J, Klein J, Matuszcak C, Runge J, Harbaum L, Klose H, Hennigs JK
Frontiers in Cardiovascular Medicine 2023
Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary Hypertension.
Wang L, Moonen JR, Cao A, Isobe S, Li CG, Tojais NF, Taylor S, Marciano DP, Chen PI, Gu M, Li D, Harper RL, El-Bizri N, Kim YM, Stankunas K, Rabinovitch M
Circulation research 2023
Pharmacology and Emerging Therapies for Group 3 Pulmonary Hypertension Due to Chronic Lung Disease.
Gonzales J, Fraidenburg DR
Pharmaceuticals (Basel, Switzerland) 2023
Impact of diabetes mellitus on disease severity and patient survival in idiopathic pulmonary arterial hypertension: data from the Polish multicentre registry (BNP-PL).
Jonas K, Kurzyna M, Mroczek E, Chrzanowski Ł, Mularek-Kubzdela T, Skoczylas I, Błaszczak P, Grześk G, Mizia-Stec K, Kuśmierczyk B, Kamiński K, Lewicka E, Peregud-Pogorzelska M, Tomaszewski M, Jacheć W, Gąsior Z, Pawlak A, Ryczek R, Pruszczyk P, Doboszyńska A, Widejko-Pietkiewicz K, Zabłocka W, Waligóra M, Kopeć G
Cardiovascular Diabetology 2023
Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
Torres G, Lancaster AC, Yang J, Griffiths M, Brandal S, Damico R, Vaidya D, Simpson CE, Martin LJ, Pauciulo MW, Nichols WC, Ivy DD, Austin ED, Hassoun PM, Everett AD
Pulmonary circulation 2023
Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer's disease risk.
Aslam MM, Fan KH, Lawrence E, Bedison MA, Snitz BE, DeKosky ST, Lopez OL, Feingold E, Kamboh MI
Molecular Psychiatry 2023
Role of PPARG in Chemosensitivity-Regulating Network for Hypopharyngeal Squamous Cell Carcinoma
Kong F, Han B, Chen J, Shen X, Hou L, Fang J, Lian M
PPAR Research 2023
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure
O Boucherat, V Agrawal, A Lawrie, S Bonnet
Circulation research 2022
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension
L Calvier, J Herz, G Hansmann
JACC: Basic to Translational Science 2022
Increased Methyl-CpG-Binding Domain Protein 2 Promotes Cigarette Smoke-Induced Pulmonary Hypertension
Wu J, Huang Q, Li Q, Gu Y, Zhan Y, Wang T, Chen J, Zeng Z, Lv Y, Zhao J, Xia J, Xie J
Frontiers in Oncology 2022
TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
Hachana S, Larrivée B
Cells 2022
Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension
Anis M, Gonzales J, Halstrom R, Baig N, Humpal C, Demeritte R, Epshtein Y, Jacobson JR, Fraidenburg DR
International journal of molecular sciences 2022
Pulmonary Arterial Hypertension: Emerging Principles of Precision Medicine across Basic Science to Clinical Practice
Kelly NJ, Chan SY
2022
Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension
Hansmann G, Chouvarine P, Diekmann F, Giera M, Ralser M, Mülleder M, von Kaisenberg C, Bertram H, Legchenko E, Hass R
Nature Cardiovascular Research 2022
ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension
D Li, NY Shao, JR Moonen, Z Zhao, M Shi, S Otsuki, L Wang, T Nguyen, E Yan, DP Marciano, K Contrepois, CG Li, JC Wu, MP Snyder, M Rabinovitch
Circulation 2021
Lung Inflammation in Health and Disease, Volume I
YX Wang
2021
Novel Experimental Therapies for Treatment of Pulmonary Arterial Hypertension
R Zolty
Journal of Experimental Pharmacology 2021
Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases
C Kuiper-Makris, J Selle, E Nüsken, J Dötsch, MA Alcazar
Frontiers in Medicine 2021
PPARγ increases HUWE1 to attenuate NF-κB/p65 and sickle cell disease with pulmonary hypertension
AJ Jang, SS Chang, C Park, CM Lee, RL Benza, MJ Passineau, J Ma, DR Archer, RL Sutliff, CM Hart, BY Kang
Blood Advances 2021
iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension
M Gu, M Donato, M Guo, N Wary, Y Miao, S Mao, T Saito, S Otsuki, L Wang, RL Harper, S Sa, P Khatri, M Rabinovitch
Science Translational Medicine 2021
PPARγ and TGFβ—Major Regulators of Metabolism, Inflammation, and Fibrosis in the Lungs and Kidneys
G Kökény, L Calvier, G Hansmann
International journal of molecular sciences 2021
Anti-inflammatory mechanisms of the vascular smooth muscle PPARγ
M Mukohda, H Ozaki
Journal of Smooth Muscle Research 2021
Endothelial Dec1-PPARγ Axis Impairs Proliferation and Apoptosis Homeostasis Under Hypoxia in Pulmonary Arterial Hypertension
X Li, C Liu, W Qi, Q Meng, H Zhao, Z Teng, R Xu, X Wu, F Zhu, Y Qin, M Zhao, F Xu, M Xia
Frontiers in Cell and Developmental Biology 2021
Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension
F Diekmann, P Chouvarine, H Sallmon, L Meyer-Kobbe, M Kieslich, BD Plouffe, SK Murthy, R Lichtinghagen, E Legchenko, G Hansmann
International journal of molecular sciences 2021
Emerging therapies for right ventricular dysfunction and failure
A Klinke, T Schubert, M Müller, E Legchenko, JG Zelt, T Shimauchi, LC Napp, AM Rothman, S Bonnet, DJ Stewart, G Hansmann, V Rudolph
Cardiovascular diagnosis and therapy 2020
Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm
R Gurung, AM Choong, CC Woo, R Foo, V Sorokin
International journal of molecular sciences 2020
CD248 as a novel therapeutic target in pulmonary arterial hypertension
T Xu, L Shao, A Wang, R Liang, Y Lin, G Wang, Y Zhao, J Hu, S Liu
Clinical and Translational Medicine 2020
Emerging antenatal therapies for congenital diaphragmatic hernia-induced pulmonary hypertension in preclinical models
K Marulanda, ND Tsihlis, SE McLean, MR Kibbe
Pediatric Research 2020
Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell–Dependent Endothelial Cell Apoptosis
G Ruffenach, E OConnor, M Vaillancourt, J Hong, N Cao, S Sarji, S Moazeni, J Papesh, V Grijalva, CM Cunningham, L Shu, A Chattopadhyay, S Tiwari, O Mercier, F Perros, S Umar, X Yang, AV Gomes, AM Fogelman, ST Reddy, M Eghbali
Hypertension 2020
Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension
KM Mair, R Gaw, MR MacLean
Pulmonary circulation 2020
Activation of the Metabolic Master Regulator PPARγ: A Potential PIOneering Therapy for Pulmonary Arterial Hypertension
G Hansmann, L Calvier, MG Risbano, SY Chan
American journal of respiratory cell and molecular biology 2020
Metabolic syndrome, neurohumoral modulation, and pulmonary arterial hypertension
BA Maron, JA Leopold, AR Hemnes
British Journal of Pharmacology 2020
PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension
JK Hennigs, A Cao, CG Li, M Shi, J Mienert, K Miyagawa, J Körbelin, DP Marciano, PI Chen, M Roughley, MV Elliott, RL Harper, MA Bill, J Chappell, JR Moonen, I Diebold, L Wang, MP Snyder, M Rabinovitch
Circulation research 2020
Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches
S Martinho, R Adão, AF Leite-Moreira, C Brás-Silva
Frontiers in Pediatrics 2020
Association of plasma adiponectin with pulmonary hypertension, mortality and heart failure in African Americans: Jackson Heart Study
S Lakshmanan, M Jankowich, WC Wu, S Abbasi, AR Morrison, G Choudhary
Pulmonary circulation 2020
The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review
Y Liu, J Wang, S Luo, Y Zhan, Q Lu
Journal of Autoimmunity 2020
Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism
V Agrawal, T Lahm, G Hansmann, AR Hemnes
Cardiovascular diagnosis and therapy 2020
Pulmonary arterial hypertension: Cellular and molecular changes in the lung
BA Maron
Global Cardiology Science and Practice 2020
Animal models of right heart failure
Andersen A, van der Feen DE, Andersen S, Schultz JG, Hansmann G, Bogaard HJ
Cardiovascular diagnosis and therapy 2020
Human PAH is characterized by a pattern of lipid-related insulin resistance
Anna Hemnes, James M Luther, Christopher Rhodes, Jason Burgess, James Carlson, Run Fan, Joshua Fessel, Niki Fortune, Robert E. Gerszten, stephen halliday, Rezzan Hekmat, Luke S Howard, John Newman, Kevin Niswender, Meredith Pugh, ivan robbins, Quanhu Sheng, cyndya shibao, Yu Shyr, Susan Sumner, Megha Talati, John Wharton, Martin R Wilkins, Fei Ye, chang yu, James West, evan brittain
JCI Insight 2019
LRP1 Deficiency in Vascular SMC Leads To Pulmonary Arterial Hypertension That Is Reversed By PPARγ Activation
L Calvier, P Boucher, J Herz, G Hansmann
Circulation research 2019
Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again
KW Prins, T Thenappan, EK Weir, R Kalra, M Pritzker, SL Archer
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2019
The Search for Disease-Modifying Therapies in Pulmonary Hypertension
CS Woodcock, SY Chan
Journal of cardiovascular pharmacology and therapeutics 2019
Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure
E Spiekerkoetter, EA Goncharova, C Guignabert, K Stenmark, G Kwapiszewska, M Rabinovitch, N Voelkel, HJ Bogaard, B Graham, SS Pullamsetti, WM Kuebler
Pulmonary circulation 2019
Forkhead box M1 transcription factor: a novel target for pulmonary arterial hypertension therapy
L Gu, HM Liu
World Journal of Pediatrics 2019
Clinical trial design and new therapies for pulmonary arterial hypertension
O Sitbon, M Gomberg-Maitland, J Granton, MI Lewis, SC Mathai, M Rainisio, NL Stockbridge, MR Wilkins, RT Zamanian, LJ Rubin
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2019
PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
CG Li, C Mahon, NM Sweeney, E Verschueren, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitch
Cell Reports 2019
Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and Systemic Inflammation in Patients with Idiopathic Pulmonary Arterial Hypertension
K Jonas, W Magoń, P Podolec, G Kopeć
Medical science monitor : international medical journal of experimental and clinical research 2019
Pulmonary arterial remodelling by deficiency of peroxisome proliferator-activated receptor-γ in murine vascular smooth muscle cells occurs independently of obesity-related pulmonary hypertension
E Caglayan, M Trappiel, A Behringer, EM Berghausen, M Odenthal, E Wellnhofer, K Kappert
Respiratory Research 2019
Novel Therapeutic Approaches of Pulmonary Arterial Hypertension
S Tyagi, V Batra
International Journal of Angiology 2019
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
V Kheirollahi, RM Wasnick, V Biasin, AI Vazquez-Armendariz, X Chu, A Moiseenko, A Weiss, J Wilhelm, JS Zhang, G Kwapiszewska, S Herold, RT Schermuly, B Mari, X Li, W Seeger, A Günther, S Bellusci, EE Agha
Nature Communications 2019
Prognostic role of traditional cardiovascular risk factors in patients with idiopathic pulmonary arterial hypertension
K Jonas, M Waligóra, W Magoń, T Zdrojewski, J Stokwiszewski, W Płazak, P Podolec, G Kopeć
Archives of Medical Science : AMS 2019
Apolipoprotein E is a Concentration-dependent Pulmonary Danger Signal that Activates the NLRP3 Inflammasome and IL-1β Secretion by Asthmatic Macrophages
Gordon EM, Yao X, Xu H, Karkowsky W, Kaler M, Kalchiem-Dekel O, Barochia AV, Gao M, Keeran KJ, Jeffries KR, Levine SJ
Journal of Allergy and Clinical Immunology 2019
Recent advances in pulmonary arterial hypertension
MR Wilkins, J Aman, L Harbaum, A Ulrich, J Wharton, CJ Rhodes
F1000Research 2018
PPARγ Knockdown Impairs Bone Morphogenetic Protein-2 (BMP2)-Induced Critical-Size Bone Defect Repair
C Wang, J Tanjaya, J Shen, S Lee, B Bisht, HC Pan, S Pang, Y Zhang, EA Berthiaume, E Chen, AL Lio, X Zhang, K Ting, S Guo, C Soo
The American Journal of Pathology 2018
Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension
V Tseng, R Sutliff, CM Hart
Antioxidants & Redox Signaling 2018
Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension
T Kudryashova, Y Shen, A Pena, E Cronin, E Okorie, D Goncharov, E Goncharova
International journal of molecular sciences 2018
Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension
L Harbaum, P Ghataorhe, J Wharton, B Jiménez, LS Howard, JS Gibbs, JK Nicholson, CJ Rhodes, MR Wilkins
Thorax 2018
Fragile Histidine Triad (FHIT) , a Novel Modifier Gene in Pulmonary Arterial Hypertension
SD Prosseda, X Tian, K Kuramoto, M Boehm, D Sudheendra, K Miyagawa, F Zhang, D Solow-Cordero, JC Saldivar, ED Austin, JE Loyd, L Wheeler, A Andruska, M Donato, L Wang, K Huebner, RJ Metzger, P Khatri, E Spiekerkoetter
American journal of respiratory and critical care medicine 2018
Consequences of BMPR2 Deficiency in the Pulmonary Vasculature and Beyond: Contributions to Pulmonary Arterial Hypertension
A Andruska, E Spiekerkoetter
International journal of molecular sciences 2018
Repurposing rosiglitazone, a PPAR-γ agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH
J Rashid, A Alobaida, TA Al-Hilal, S Hammouda, IF McMurtry, E Nozik-Grayck, KR Stenmark, F Ahsan
Journal of Controlled Release 2018
Pulmonary vascular dysfunction in metabolic syndrome
C Willson, M Watanabe, A Tsuji-Hosokawa, A Makino
The Journal of Physiology 2018
Pharmacological activation of PPARγ inhibits hypoxia-induced proliferation through a caveolin-1-targeted and -dependent mechanism in PASMCs
K Yang, M Zhao, J Huang, C Zhang, Q Zheng, Y Chen, H Jiang, W Lu, J Wang
American journal of physiology. Cell physiology 2018
Metabolic Status in Patients with Operable vs. Inoperable Left-to-Right Shunts
D Luo, C Zhang, Y Huang, T Huang, H Li
Medical science monitor : international medical journal of experimental and clinical research 2018
Associations between diabetes mellitus and pulmonary hypertension in chronic respiratory disease patients
T Takahashi, A Yoshihisa, K Sugimoto, T Yokokawa, T Misaka, T Kaneshiro, M Oikawa, A Kobayashi, K Nakazato, T Ishida, Y Takeishi, Y Fukumoto
PloS one 2018
Drug abuse and HIV related pulmonary hypertension: double hit injury
ZJ Harter, S Agarwal, P Dalvi, NF Voelkel, NK Dhillon
AIDS 2018
The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study
AM Kulminski, AV Barochia, Y Loika, N Raghavachari, KG Arbeev, MK Wojczynski, B Thyagarajan, BN Vardarajan, K Christensen, AI Yashin, SJ Levine, SD Ginsberg
PloS one 2018
Prenatal treatment with rosiglitazone attenuates vascular remodeling and pulmonary monocyte influx in experimental congenital diaphragmatic hernia
JH Gosemann, F Friedmacher, A Hofmann, J Zimmer, JF Kuebler, S Rittinghausen, A Suttkus, M Lacher, L Alvarez, N Corcionivoschi, P Puri, J West
PloS one 2018
Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension
S Bonnet, S Provencher, C Guignabert, F Perros, O Boucherat, RT Schermuly, PM Hassoun, M Rabinovitch, MR Nicolls, M Humbert
American journal of respiratory and critical care medicine 2017
BMP type II receptor as a therapeutic target in pulmonary arterial hypertension
M Orriols, MC Gomez-Puerto, P Dijke
Cellular and Molecular Life Sciences 2017
Emerging Metabolic Therapies in Pulmonary Arterial Hypertension
L Harvey, S Chan
Journal of Clinical Medicine 2017
Peroxisome Proliferator-Activated Receptor γ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung
BY Kang, K Park, JM Kleinhenz, TC Murphy, RL Sutliff, D Archer, CM Hart
American journal of respiratory cell and molecular biology 2017
Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway
YJ Lai, HH Hsu, GJ Chang, SH Lin, WJ Chen, CC Huang, JH Pang
Scientific Reports 2017
PPARγ attenuates hypoxia-induced hypertrophic transcriptional pathways in the heart
A Chaudhry, KA Carthan, BY Kang, J Calvert, RL Sutliff, CM Hart
Pulmonary circulation 2017
Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy
S Umar, R Partow-Navid, G Ruffenach, A Iorga, S Moazeni, M Eghbali
Biology of sex differences 2017
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
CJ Rhodes, J Wharton, P Ghataorhe, G Watson, B Girerd, LS Howard, JS Gibbs, R Condliffe, CA Elliot, DG Kiely, G Simonneau, D Montani, O Sitbon, H Gall, RT Schermuly, HA Ghofrani, A Lawrie, M Humbert, MR Wilkins
The Lancet Respiratory Medicine 2017
Baicalin attenuates monocrotaline-induced pulmonary hypertension through bone morphogenetic protein signaling pathway
Z Zhang, L Zhang, C Sun, F Kong, J Wang, Q Xin, W Jiang, K Li, O Chen, Y Luan
Oncotarget 2017
Altered expression of PPAR‑γ and TRPC in neonatal rats with persistent pulmonary hypertension
Y Du, J Fu, L Yao, L Qiao, N Liu, Y Xing, X Xue
Molecular medicine reports 2017
5-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway
R Ke, X Xie, S Li, Y Pan, J Wang, X Yan, W Zang, L Gao, M Li
Oncotarget 2017
Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice
SY Chan, LJ Rubin
European Respiratory Review 2017
Incidental pulmonary arterial dilatation and coronary calcifications in patients with hypertension and normal findings on myocardial perfusion technetium-99m sestamibi single-photon emission computed tomography.
Santhanam P, Marcus C, Solnes LB, Kral BG, Javadi MS, Rowe SP
Journal of clinical hypertension (Greenwich, Conn.) 2017
Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling
S Wang, H Zeng, XJ Xie, YK Tao, X He, RJ Roman, JL Aschner, JX Chen
Oncotarget 2016
Transcription Factors, Transcriptional Coregulators, and Epigenetic Modulation in the Control of Pulmonary Vascular Cell Phenotype: Therapeutic Implications for Pulmonary Hypertension (2015 Grover Conference Series)
SS Pullamsetti, F Perros, P Chelladurai, J Yuan, K Stenmark
Pulmonary circulation 2016
Update on novel targets and potential treatment avenues in pulmonary hypertension
JC Huetsch, K Suresh, M Bernier, LA Shimoda
American journal of physiology. Lung cellular and molecular physiology 2016
PPARγ signaling and emerging opportunities for improved therapeutics
S Wang, EJ Dougherty, RL Danner
Pharmacological Research 2016
Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension
A Behringer, M Trappiel, EM Berghausen, H Freyhaus, E Wellnhofer, M Odenthal, F Blaschke, F Er, N Gassanov, S Rosenkranz, S Baldus, K Kappert, E Caglayan
Naunyn-Schmiedeberg's Archives of Pharmacology 2016
PDGF-dependent β-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension
J Takahashi, M Orcholski, K Yuan, VJ Perez, N Mantei
FEBS Letters 2016
PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation
JR Sysol, V Natarajan, RF Machado
American journal of physiology. Cell physiology 2016
Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease
X Yao, EM Gordon, DM Figueroa, AV Barochia, SJ Levine
American journal of respiratory cell and molecular biology 2016
Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle
MH Talati, EL Brittain, JP Fessel, N Penner, J Atkinson, M Funke, C Grueter, WG Jerome, M Freeman, JH Newman, J West, AR Hemnes
American journal of respiratory and critical care medicine 2016
Role of oxidized lipids in pulmonary arterial hypertension
S Sharma, G Ruffenach, S Umar, N Motayagheni, ST Reddy, M Eghbali
Pulmonary circulation 2016
Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells
JI Blum, KM Bijli, TC Murphy, JM Kleinhenz, CM Hart
The American Journal of the Medical Sciences 2016
Peroxisome Proliferator–Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling
BY Kang, KK Park, JM Kleinhenz, TC Murphy, DE Green, KM Bijli, SM Yeligar, KA Carthan, CD Searles, RL Sutliff, CM Hart
American journal of respiratory cell and molecular biology 2016
Update in Pulmonary Vascular Disease 2015
BA Maron, MT Gladwin, MA Simon
American journal of respiratory and critical care medicine 2016
Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension
K Yuan, NY Shao, JK Hennigs, M Discipulo, ME Orcholski, E Shamskhou, A Richter, X Hu, JC Wu, VA de Perez
The American Journal of Pathology 2016
Proline-rich tyrosine kinase 2 downregulates peroxisome proliferator–activated receptor gamma to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation
KM Bijli, BY Kang, RL Sutliff, CM Hart
Pulmonary circulation 2016
Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis
Q Jiang, W Lu, K Yang, C Hadadi, X Fu, Y Chen, X Yun, J Zhang, M Li, L Xu, H Tang, JX Yuan, J Wang, D Sun
American journal of physiology. Cell physiology 2016
Novel Methods in Pulmonary Hypertension Phenotyping in the Age of Precision Medicine (2015 Grover Conference Series)
JW Barnes, AR Tonelli, GA Heresi, JE Newman, NE Mellor, DE Grove, RA Dweik
Pulmonary circulation 2016
Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells
J Chen, X Cui, Z Qian, Y Li, K Kang, J Qu, L Li, D Gou
BMC Genomics 2016
Sex Affects BMPR-II Signalling in Pulmonary Artery Smooth Muscle Cells
KM Mair, XD Yang, L Long, K White, E Wallace, MA Ewart, CK Docherty, NW Morrell, MR MacLean
American journal of respiratory and critical care medicine 2015
A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis
RG Marangoni, BD Korman, Y Allanore, P Dieude, LL Armstrong, M Rzhetskaya, M Hinchcliff, M Carns, S Podlusky, SJ Shah, B Ruiz, E Hachulla, K Tiev, JL Cracowski, J Varga, MG Hayes
Arthritis Research & Therapy 2015
Impact of diabetes in patients with pulmonary hypertension
AD Abernethy, K Stackhouse, S Hart, G Devendra, TM Bashore, R Dweik, RA Krasuski
Pulmonary circulation 2015
Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation
KM Bijli, JM Kleinhenz, TC Murphy, BY Kang, SE Adesina, RL Sutliff, CM Hart
Free radical biology & medicine 2015
BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
I Diebold, JK Hennigs, K Miyagawa, CG Li, NP Nickel, M Kaschwich, A Cao, L Wang, S Reddy, PI Chen, K Nakahira, MA Alcazar, RK Hopper, L Ji, BJ Feldman, M Rabinovitch
Cell Metabolism 2015
Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling
NP Nickel, E Spiekerkoetter, M Gu, CG Li, H Li, M Kaschwich, I Diebold, JK Hennigs, KY Kim, K Miyagawa, L Wang, A Cao, S Sa, X Jiang, RW Stockstill, MR Nicolls, RT Zamanian, RD Bland, M Rabinovitch
American journal of respiratory and critical care medicine 2015
Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system: Bone morphogenetic proteins and cardiovascular regulation
JY Luo, Y Zhang, L Wang, Y Huang
The Journal of Physiology 2015
PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21
DE Green, TC Murphy, BY Kang, CD Searles, CM Hart, J West
PloS one 2015
Activation of peroxisome proliferator-activated receptor γ ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
X Xie, G Wang, D Zhang, Y Zhang, Y Zhu, F Li, S Li, M Li
Biomedical Reports 2015
Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels
K Yang, W Lu, J Jia, J Zhang, M Zhao, S Wang, H Jiang, L Xu, J Wang
American journal of physiology. Cell physiology 2015
G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY
S Wang, KS Awad, JM Elinoff, EJ Dougherty, GA Ferreyra, JY Wang, R Cai, J Sun, A Ptasinska, RL Danner
The Journal of biological chemistry 2015
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit
T Bertero, KA Cottrill, Y Lu, CM Haeger, P Dieffenbach, S Annis, A Hale, B Bhat, V Kaimal, YY Zhang, BB Graham, R Kumar, R Saggar, R Saggar, WD Wallace, DJ Ross, SM Black, S Fratz, JR Fineman, SO Vargas, KJ Haley, AB Waxman, BN Chau, LE Fredenburgh, SY Chan
Cell Reports 2015
Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension
TV Kudryashova, DA Goncharov, A Pena, K Ihida-Stansbury, H DeLisser, SM Kawut, EA Goncharova
Pulmonary circulation 2015
Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells
KS Awad, JM Elinoff, S Wang, S Gairhe, GA Ferreyra, R Cai, J Sun, MA Solomon, RL Danner
American journal of physiology. Lung cellular and molecular physiology 2015
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Thomas Bertero, Yu Lu, Sofia Annis, Andrew Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Rahul Kumar, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, James D. West, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Katherine A. Cottrill, Stephen Y. Chan
Journal of Clinical Investigation 2014
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
H Sawada, T Saito, NP Nickel, TP Alastalo, JP Glotzbach, R Chan, L Haghighat, G Fuchs, M Januszyk, A Cao, YJ Lai, VJ Perez, YM Kim, L Wang, PI Chen, E Spiekerkoetter, Y Mitani, GC Gurtner, P Sarnow, M Rabinovitch
Journal of Experimental Medicine 2014
Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
M Rabinovitch, C Guignabert, M Humbert, MR Nicolls
Circulation research 2014
Pulmonary Arterial Hypertension and Insulin Resistance
DB Bradley
Journal of molecular and genetic medicine : an international journal of biomedical research 2014
Peripheral Blood Signature of Vasodilator-Responsive Pulmonary Arterial Hypertension
AR Hemnes, AW Trammell, SL Archer, S Rich, C Yu, H Nian, N Penner, M Funke, L Wheeler, IM Robbins, ED Austin, JH Newman, J West
Circulation 2014
Rosiglitazone Attenuated Endothelin-1-Induced Vasoconstriction of Pulmonary Arteries in the Rat Model of Pulmonary Arterial Hypertension via Differential Regulation of ET-1 Receptors
Y Liu, XY Tian, Y Huang, N Wang
PPAR Research 2014
Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension
L Benson, EL Brittain, ME Pugh, ED Austin, K Fox, L Wheeler, IM Robbins, AR Hemnes
Pulmonary circulation 2014
Targeting the Wnt signaling pathways in pulmonary arterial hypertension
VJ Perez, K Yuan, TP Alastalo, E Spiekerkoetter, M Rabinovitch
Drug Discovery Today 2014
The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up
SH Vitali, G Hansmann, C Rose, A Fernandez-Gonzalez, A Scheid, SA Mitsialis, S Kourembanas
Pulmonary circulation 2014
The MicroRNA-130/301 Family Controls Vasoconstriction in Pulmonary Hypertension
T Bertero, K Cottrill, A Krauszman, Y Lu, S Annis, A Hale, B Bhat, AB Waxman, BN Chau, WM Kuebler, SY Chan
The Journal of biological chemistry 2014
FK506 Activates BMPR2 Signaling, Rescues Endothelial Dysfunction, Reverses Pulmonary Hypertension
Edda Spiekerkoetter, Xuefei Tian, Jie Cai, Rachel Hopper, Deepti Sudheendra, Caiyun Grace Li, Nesrine El-Bizri, Hirofumi Sawada, Roxanna Haghighat, Roshelle Chan, Leila Haghighat, Vinicio de Jesus Perez, Lingli Wang, Sushma Reddy, Mingming Zhao, Daniel Bernstein, David Solow-Cordero, Philip A. Beachy, Thomas Wandless, Peter Ten Dijke, Marlene Rabinovitch
Journal of Clinical Investigation 2013
mTORC2 Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation and Survival in Pulmonary Arterial Hypertension
DA Goncharov, TV Kudryashova, H Ziai, K Ihida-Stansbury, H Delisser, VP Krymskaya, RM Tuder, SM Kawut, EA Goncharova
Circulation 2013
A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension
R Schwappacher, A Kilic, B Kojonazarov, M Lang, T Diep, S Zhuang, T Gawlowski, RT Schermuly, A Pfeifer, GR Boss, RB Pilz
The Journal of biological chemistry 2013
Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension
NW Morrell, SL Archer, A Defelice, S Evans, M Fiszman, T Martin, M Saulnier, M Rabinovitch, R Schermuly, D Stewart, H Truebel, G Walker, KR Stenmark
Pulmonary circulation 2013
Critical Role for the Advanced Glycation End‐Products Receptor in Pulmonary Arterial Hypertension Etiology
J Meloche, A Courchesne, M Barrier, S Carter, M Bisserier, R Paulin, JF LauzonJoset, S BreuilsBonnet, È Tremblay, S Biardel, C Racine, C Courture, P Bonnet, SM Majka, Y Deshaies, F Picard, S Provencher, S Bonnet
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2013
Signal transduction in the development of pulmonary arterial hypertension
S Malenfant, AS Neyron, R Paulin, F Potus, J Meloche, S Provencher, S Bonnet
Pulmonary circulation 2013
Hypoxia downregulates PPARγ via an ERK1/2–NF-κB–Nox4-dependent mechanism in human pulmonary artery smooth muscle cells
X Lu, KM Bijli, A Ramirez, TC Murphy, J Kleinhenz, CM Hart
Free radical biology & medicine 2013
Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension
AR Hemnes, EL Brittain, AW Trammell, JP Fessel, ED Austin, N Penner, KB Maynard, L Gleaves, M Talati, T Absi, T Disalvo, J West
American journal of respiratory and critical care medicine 2013
Effects of propofol on renal ischemia/reperfusion injury in rats
S Yang, WP Chou, L Pei
Experimental and therapeutic medicine 2013
Hyperoxia Synergizes with Mutant Bone Morphogenic Protein Receptor 2 to Cause Metabolic Stress, Oxidant Injury, and Pulmonary Hypertension
JP Fessel, CR Flynn, LJ Robinson, NL Penner, S Gladson, CJ Kang, DH Wasserman, AR Hemnes, JD West
American journal of respiratory cell and molecular biology 2013
Oct-2 Transcription Factor Binding Activity and Expression Up-Regulation in Rat Cerebral Ischaemia is Associated with a Diminution of Neuronal Damage In Vitro
S Camós, C Gubern, M Sobrado, R Rodríguez, VG Romera, MÁ Moro, I Lizasoain, J Serena, J Mallolas, M Castellanos
NeuroMolecular Medicine 2013
Interdisciplinary networks for the treatment of childhood pulmonary vascular disease: what pulmonary hypertension doctors can learn from pediatric oncologists
G Hansmann
Pulmonary circulation 2013
Sildenafil Inhibits Hypoxia-Induced Transient Receptor Potential Canonical Protein Expression in Pulmonary Arterial Smooth Muscle via cGMP-PKG-PPARγ Axis
J Wang, K Yang, L Xu, Y Zhang, N Lai, H Jiang, Y Zhang, N Zhong, P Ran, W Lu
American journal of respiratory cell and molecular biology 2013
Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature
BY Kang, KK Park, DE Green, KM Bijli, CD Searles, RL Sutliff, CM Hart
PloS one 2013
Peroxisome proliferator activated receptor- -Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension
J Gien, N Tseng, G Seedorf, G Roe, SH Abman
American journal of physiology. Lung cellular and molecular physiology 2013
Endothelin-1 decreases endothelial PPAR  signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension
D Wolf, N Tseng, G Seedorf, G Roe, SH Abman, J Gien
American journal of physiology. Lung cellular and molecular physiology 2013
Downregulation of Bone Morphogenetic Protein Receptor Axis During HIV-1 and Cocaine-Mediated Pulmonary Smooth Muscle Hyperplasia: Implications for HIV-Related Pulmonary Arterial Hypertension
P Dalvi, A O'Brien-Ladner, NK Dhillon
Arteriosclerosis, thrombosis, and vascular biology 2013
SMAD1 Deficiency in Either Endothelial or Smooth Muscle Cells Can Predispose Mice to Pulmonary Hypertension
C Han, KH Hong, YH Kim, MJ Kim, C Song, MJ Kim, SJ Kim, MK Raizada, SP Oh
Hypertension 2013
Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism
V Karoor, M Oka, SJ Walchak, LB Hersh, YE Miller, EC Dempsey
Hypertension 2013
Hypoxia-Inducible Factor-1α in Pulmonary Artery Smooth Muscle Cells Lowers Vascular Tone by Decreasing Myosin Light Chain Phosphorylation
YM Kim, EA Barnes, CM Alvira, L Ying, S Reddy, DN Cornfield
Circulation research 2013
New horizons in pulmonary arterial hypertension therapies
Galiè N, Ghofrani AH
European Respiratory Review 2013
Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch
Journal of Clinical Investigation 2012
Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
AG Hameed, ND Arnold, J Chamberlain, JA Pickworth, C Paiva, S Dawson, S Cross, L Long, L Zhao, NW Morrell, DC Crossman, CM Newman, DG Kiely, SE Francis, A Lawrie
Journal of Experimental Medicine 2012
A process-based review of mouse models of pulmonary hypertension
M Das, J Fessel, H Tang, J West
Pulmonary circulation 2012
A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
J Gomez-Arroyo, SJ Saleem, S Mizuno, AA Syed, HJ Bogaard, A Abbate, L Taraseviciene-Stewart, Y Sung, D Kraskauskas, D Farkas, DH Conrad, MR Nicolls, NF Voelkel
American journal of physiology. Lung cellular and molecular physiology 2012
Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization
C Iosef, TP Alastalo, Y Hou, C Chen, ES Adams, SC Lyu, DN Cornfield, CM Alvira
American journal of physiology. Lung cellular and molecular physiology 2012
Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation
SA Aljubran, R Cox, PT Parthasarathy, GK Ramanathan, V Rajanbabu, H Bao, SM Mohapatra, R Lockey, N Kolliputi
PloS one 2012
Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension
G Marsboom, C Wietholt, CR Haney, PT Toth, JJ Ryan, E Morrow, T Thenappan, P Bache-Wiig, L Piao, J Paul, CT Chen, SL Archer
American journal of respiratory and critical care medicine 2012
Today’s and tomorrow’s imaging and circulating biomarkers for pulmonary arterial hypertension
M Barrier, J Meloche, MH Jacob, A Courboulin, S Provencher, S Bonnet
Cellular and Molecular Life Sciences 2012
PPAR-γ Regulates Carnitine Homeostasis and Mitochondrial Function in a Lamb Model of Increased Pulmonary Blood Flow
S Sharma, X Sun, R Rafikov, S Kumar, Y Hou, PE Oishi, SA Datar, G Raff, JR Fineman, SM Black
PloS one 2012
Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis
J Wei, S Bhattacharyya, M Jain, J Varga
The open rheumatology journal 2012
BMP-2 Up-Regulates PTEN Expression and Induces Apoptosis of Pulmonary Artery Smooth Muscle Cells under Hypoxia
W Pi, X Guo, L Su, W Xu
PloS one 2012
Increased activation of NADPH oxidase 4 in the pulmonary vasculature in experimental diaphragmatic hernia
JH Gosemann, F Friedmacher, M Hunziker, L Alvarez, N Corcionivoschi, P Puri
Pediatric Surgery International 2012
Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb
S Sharma, J Barton, R Rafikov, S Aggarwal, HC Kuo, PE Oishi, SA Datar, JR Fineman, SM Black
Pulmonary Pharmacology & Therapeutics 2012
Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1
M Li, Y Liu, H Shi, Y Zhang, G Wang, J Xu, J Lu, D Zhang, X Xie, D Han, Y Wu, S Li
Naunyn-Schmiedeberg's Archives of Pharmacology 2012
The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation
DE Green, TC Murphy, BY Kang, JM Kleinhenz, C Szyndralewiez, P Page, RL Sutliff, CM Hart
American journal of respiratory cell and molecular biology 2012
A potential role for insulin resistance in experimental pulmonary hypertension
J West, KD Niswender, JA Johnson, ME Pugh, L Gleaves, JP Fessel, AR Hemnes
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012
Pulmonary hypertension: the science behind the disease spectrum
Wilkins MR
European Respiratory Review 2012
Dysfunctional BMP Signaling is Rescued via PPARγ-β-catenin-Mediated Regulation of Apelin in Humans and Mice
Tero-Pekka Alastalo, Molong Li, Vinicio de Jesus Perez, David Pham, Hirofumi Sawada, Jordon Wang, Minna Koskenvuo, Lingli Wang, Bruce Freeman, Howard Chang, Marlene Rabinovitch
Journal of Clinical Investigation 2011
Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension
G Hansmann, BD Plouffe, A Hatch, A Gise, H Sallmon, RT Zamanian, SK Murthy
Journal of Molecular Medicine 2011
Genetically manipulated mouse models of lung disease: potential and pitfalls
RM Baron, AJ Choi, CA Owen, AM Choi
American journal of physiology. Lung cellular and molecular physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Mechanisms of disease: pulmonary arterial hypertension
RT Schermuly, HA Ghofrani, MR Wilkins, F Grimminger
Nature Reviews Cardiology 2011
Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension
MA Sparks, KK Parsons, J Stegbauer, SB Gurley, A Vivekanandan-Giri, CN Fortner, J Snouwaert, EW Raasch, RC Griffiths, TA Haystead, TH Le, S Pennathur, B Koller, TM Coffman
Hypertension 2011
New perspectives for the treatment of pulmonary hypertension
RS Baliga, RJ MacAllister, AJ Hobbs
British Journal of Pharmacology 2011
Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension
M Weng, DM Baron, KD Bloch, AD Luster, JJ Lee, BD Medoff
American journal of physiology. Lung cellular and molecular physiology 2011
Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions?
R Summer, K Walsh, BD Medoff
Pulmonary circulation 2011
Is peroxisome proliferator-activated receptor gamma (PPARγ) a therapeutic target for the treatment of pulmonary hypertension?
DE Green, RL Sutliff, CM Hart
Pulmonary circulation 2011
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner
A Lawrie, AG Hameed, J Chamberlain, N Arnold, A Kennerley, K Hopkinson, J Pickworth, DG Kiely, DC Crossman, SE Francis
The American Journal of Pathology 2011
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
VA de Perez, Z Ali, TP Alastalo, F Ikeno, H Sawada, YJ Lai, T Kleisli, E Spiekerkoetter, X Qu, LH Rubinos, E Ashley, M Amieva, S Dedhar, M Rabinovitch
The Journal of Cell Biology 2011
HO-1 Induced by Cilostazol Protects Against TNF-α-associated Cytotoxicity via a PPAR-γ-dependent Pathway in Human Endothelial Cells
SY Park, JU Bae, KW Hong, CD Kim
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011
Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension
I Morecroft, B Doyle, M Nilsen, W Kolch, K Mair, MR Maclean
British Journal of Pharmacology 2011
Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
Y Dempsie, M Nilsen, K White, KM Mair, L Loughlin, N Ambartsumian, M Rabinovitch, MR Maclean
Respiratory Research 2011
Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH
K White, L Loughlin, Z Maqbool, M Nilsen, J McClure, Y Dempsie, AH Baker, MR MacLean
Physiological genomics 2011
The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo
BY Kang, JM Kleinhenz, TC Murphy, CM Hart
American journal of physiology. Lung cellular and molecular physiology 2011
Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
K Gong, D Xing, P Li, B Aksut, N Ambalavanan, Q Yang, SE Nozell, S Oparil, YF Chen
American journal of physiology. Lung cellular and molecular physiology 2011
Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation
A Gangopahyay, M Oran, EM Bauer, JW Wertz, SA Comhair, SC Erzurum, PM Bauer
The Journal of biological chemistry 2011
Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease
S Fratz, JR Fineman, A Görlach, S Sharma, P Oishi, C Schreiber, T Kietzmann, I Adatia, J Hess, SM Black
Circulation 2011
cGMP and PKGI are required for vascular BMP signaling
Schwappacher R, Diep T, Boss G, Pilz R
BMC pharmacology 2011
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension
L Tu, L Dewachter, B Gore, E Fadel, P Dartevelle, G Simonneau, M Humbert, S Eddahibi, C Guignabert
American journal of respiratory cell and molecular biology 2010
Adiponectin Decreases Pulmonary Arterial Remodeling in Murine Models of Pulmonary Hypertension
M Weng, MJ Raher, P Leyton, TP Combs, PE Scherer, KD Bloch, BD Medoff
American journal of respiratory cell and molecular biology 2010
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies
SL Archer, EK Weir, MR Wilkins
Circulation 2010
Vascular smooth muscle cell PPARγ deletion promotes abdominal aortic aneurysms
M Hamblin, L Chang, H Zhang, K Yang, J Zhang, YE Chen
Journal of Vascular Surgery 2010
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
R Rajkumar, K Konishi, TJ Richards, DC Ishizawar, AC Wiechert, N Kaminski, F Ahmad
American journal of physiology. Heart and circulatory physiology 2010
PPARgamma as a potential therapeutic target in pulmonary hypertension
RL Sutliff, BY Kang, CM Hart
Therapeutic advances in respiratory disease 2010
Cellular and molecular aspects of vascular dysfunction in systemic sclerosis
M Trojanowska
Nature Reviews Rheumatology 2010
Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension
E Falcetti, SM Hall, PG Phillips, J Patel, NW Morrell, SG Haworth, LH Clapp
American journal of respiratory and critical care medicine 2010
Pulmonary hypertension in women
ME Pugh, AR Hemnes
Expert Review of Cardiovascular Therapy 2010
Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis
J Wei, S Bhattacharyya, J Varga
Current Opinion in Rheumatology 2010
Metabolic and Hormonal Derangements in Pulmonary Hypertension: From Mouse to Man
ME Pugh, AR Hemnes
International journal of clinical practice. Supplement 2010
PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB
X Lu, TC Murphy, MS Nanes, CM Hart
AJP Lung Cellular and Molecular Physiology 2010
Effect of Cocaine on Human Immunodeficiency Virus–Mediated Pulmonary Endothelial and Smooth Muscle Dysfunction
NK Dhillon, F Li, B Xue, O Tawfik, S Morgello, S Buch, AO Ladner
American journal of respiratory cell and molecular biology 2010
Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells
W Lu, P Ran, D Zhang, N Lai, N Zhong, J Wang
AJP Cell Physiology 2010
Update on Pulmonary Hypertension 2009
MT Gladwin, HA Ghofrani
American journal of respiratory and critical care medicine 2010
Persistent eNOS Activation Secondary to Caveolin-1 Deficiency Induces Pulmonary Hypertension through Protein Kinase G Nitration
You-Yang Zhao, Yidan D. Zhao*, Muhammad K. Mirza*, Julia H. Huang, Hari-Hara S.K. Potula, Steven M. Vogel, Viktor Brovkovych, Jason X-J Yuan, John Wharton, and Asrar B. Malik
Journal of Clinical Investigation 2009
Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension
L Chang, L Villacorta, J Zhang, MT Garcia-Barrio, K Yang, M Hamblin, SE Whitesall, LG D'Alecy, YE Chen
Circulation 2009
Notch3 signaling promotes the development of pulmonary arterial hypertension
X Li, X Zhang, R Leathers, A Makino, C Huang, P Parsa, J Macias, JX Yuan, SW Jamieson, PA Thistlethwaite
Nature Medicine 2009
Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension
C Agard, M Rolli-Derkinderen, E Dumas-de-La-Roque, M Rio, C Sagan, JP Savineau, G Loirand, P Pacaud
British Journal of Pharmacology 2009
Hemodynamic Forces, Vascular Oxidative Stress, and Regulation of BMP-2/4 Expression
A Csiszar, S Lehoux, Z Ungvari
Antioxidants & Redox Signaling 2009
Prostaglandin E 2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation
A Lundequist, SN Nallamshetty, W Xing, C Feng, TM Laidlaw, S Uematsu, S Akira, JA Boyce
Journal of immunology (Baltimore, Md. : 1950) 2009
S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4
E Spiekerkoetter, C Guignabert, V de Jesus Perez, TP Alastalo, JM Powers, L Wang, A Lawrie, N Ambartsumian, AM Schmidt, M Berryman, RH Ashley, M Rabinovitch
Circulation research 2009
The role of peroxisome proliferator-activated receptor γ in blood pressure regulation
M Hamblin, L Chang, J Zhang, YE Chen
Current Hypertension Reports 2009
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
C Guignabert, CM Alvira, TP Alastalo, H Sawada, G Hansmann, M Zhao, L Wang, N El-Bizri, M Rabinovitch
American journal of physiology. Lung cellular and molecular physiology 2009
Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model
RE Nisbet, JM Bland, DJ Kleinhenz, PO Mitchell, ER Walp, RL Sutliff, CM Hart
American journal of respiratory cell and molecular biology 2009
Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch
Journal of Clinical Investigation 2008
PPARγ and its ligands: therapeutic implications in cardiovascular disease
L Villacorta, FJ Schopfer, J Zhang, BA Freeman, YE Chen
Clinical Science 2008
Insulin resistance in pulmonary arterial hypertension
RT Zamanian, G Hansmann, S Snook, D Lilienfeld, KM Rappaport, GM Reaven, M Rabinovitch, RL Doyle
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008

← Previous 1 2 … 8 9 10 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 2 patents
Referenced in 1 Wikipedia pages
121 readers on Mendeley
See more details