Loss-of-function mutations in bone morphogenetic protein receptor II (BMP-RII) are linked to pulmonary arterial hypertension (PAH); the ligand for BMP-RII, BMP-2, is a negative regulator of SMC growth. Here, we report an interplay between PPARγ and its transcriptional target apoE downstream of BMP-2 signaling. BMP-2/BMP-RII signaling prevented PDGF-BB–induced proliferation of human and murine pulmonary artery SMCs (PASMCs) by decreasing nuclear phospho-ERK and inducing DNA binding of PPARγ that is independent of Smad1/5/8 phosphorylation. Both BMP-2 and a PPARγ agonist stimulated production and secretion of apoE by SMCs. Using a variety of methods, including short hairpin RNAi in human PASMCs, PAH patient–derived BMP-RII mutant PASMCs, a PPARγ antagonist, and PASMCs isolated from PPARγ- and apoE-deficient mice, we demonstrated that the antiproliferative effect of BMP-2 was BMP-RII, PPARγ, and apoE dependent. Furthermore, we created mice with targeted deletion of PPARγ in SMCs and showed that they spontaneously developed PAH, as indicated by elevated RV systolic pressure, RV hypertrophy, and increased muscularization of the distal pulmonary arteries. Thus, PPARγ-mediated events could protect against PAH, and PPARγ agonists may reverse PAH in patients with or without BMP-RII dysfunction.
Georg Hansmann, Vinicio A. de Jesus Perez, Tero-Pekka Alastalo, Cristina M. Alvira, Christophe Guignabert, Janine M. Bekker, Stefan Schellong, Takashi Urashima, Lingli Wang, Nicholas W. Morrell, Marlene Rabinovitch
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Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism
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Circulation research | 2019 |
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2019 |
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Journal of cardiovascular pharmacology and therapeutics | 2019 |
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World Journal of Pediatrics | 2019 |
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The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2019 |
PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis
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Cell Reports | 2019 |
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Cellular and Molecular Life Sciences | 2017 |
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Journal of Clinical Medicine | 2017 |
Peroxisome Proliferator-Activated Receptor γ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung
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American journal of respiratory cell and molecular biology | 2017 |
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Scientific Reports | 2017 |
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The Lancet Respiratory Medicine | 2017 |
Baicalin attenuates monocrotaline-induced pulmonary hypertension through bone morphogenetic protein signaling pathway
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Molecular medicine reports | 2017 |
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European Respiratory Review | 2017 |
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Journal of clinical hypertension (Greenwich, Conn.) | 2017 |
Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling
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Oncotarget | 2016 |
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SS Pullamsetti, F Perros, P Chelladurai, J Yuan, K Stenmark |
Pulmonary circulation | 2016 |
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JC Huetsch, K Suresh, M Bernier, LA Shimoda |
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Pioglitazone alleviates cardiac and vascular remodelling and improves survival in monocrotaline induced pulmonary arterial hypertension
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Naunyn-Schmiedeberg's Archives of Pharmacology | 2016 |
PDGF-dependent β-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension
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FEBS Letters | 2016 |
PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation
JR Sysol, V Natarajan, RF Machado |
American journal of physiology. Cell physiology | 2016 |
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American journal of respiratory cell and molecular biology | 2016 |
Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle
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American journal of respiratory and critical care medicine | 2016 |
Role of oxidized lipids in pulmonary arterial hypertension
S Sharma, G Ruffenach, S Umar, N Motayagheni, ST Reddy, M Eghbali |
Pulmonary circulation | 2016 |
Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells
JI Blum, KM Bijli, TC Murphy, JM Kleinhenz, CM Hart |
The American Journal of the Medical Sciences | 2016 |
Peroxisome Proliferator–Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling
BY Kang, KK Park, JM Kleinhenz, TC Murphy, DE Green, KM Bijli, SM Yeligar, KA Carthan, CD Searles, RL Sutliff, CM Hart |
American journal of respiratory cell and molecular biology | 2016 |
Update in Pulmonary Vascular Disease 2015
BA Maron, MT Gladwin, MA Simon |
American journal of respiratory and critical care medicine | 2016 |
Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension
K Yuan, NY Shao, JK Hennigs, M Discipulo, ME Orcholski, E Shamskhou, A Richter, X Hu, JC Wu, VA de Perez |
The American Journal of Pathology | 2016 |
Proline-rich tyrosine kinase 2 downregulates peroxisome proliferator–activated receptor gamma to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation
KM Bijli, BY Kang, RL Sutliff, CM Hart |
Pulmonary circulation | 2016 |
Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis
Q Jiang, W Lu, K Yang, C Hadadi, X Fu, Y Chen, X Yun, J Zhang, M Li, L Xu, H Tang, JX Yuan, J Wang, D Sun |
American journal of physiology. Cell physiology | 2016 |
Novel Methods in Pulmonary Hypertension Phenotyping in the Age of Precision Medicine (2015 Grover Conference Series)
JW Barnes, AR Tonelli, GA Heresi, JE Newman, NE Mellor, DE Grove, RA Dweik |
Pulmonary circulation | 2016 |
Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells
J Chen, X Cui, Z Qian, Y Li, K Kang, J Qu, L Li, D Gou |
BMC Genomics | 2016 |
Sex Affects BMPR-II Signalling in Pulmonary Artery Smooth Muscle Cells
KM Mair, XD Yang, L Long, K White, E Wallace, MA Ewart, CK Docherty, NW Morrell, MR MacLean |
American journal of respiratory and critical care medicine | 2015 |
A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis
RG Marangoni, BD Korman, Y Allanore, P Dieude, LL Armstrong, M Rzhetskaya, M Hinchcliff, M Carns, S Podlusky, SJ Shah, B Ruiz, E Hachulla, K Tiev, JL Cracowski, J Varga, MG Hayes |
Arthritis Research & Therapy | 2015 |
Impact of diabetes in patients with pulmonary hypertension
AD Abernethy, K Stackhouse, S Hart, G Devendra, TM Bashore, R Dweik, RA Krasuski |
Pulmonary circulation | 2015 |
Peroxisome proliferator-activated receptor gamma depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation
KM Bijli, JM Kleinhenz, TC Murphy, BY Kang, SE Adesina, RL Sutliff, CM Hart |
Free radical biology & medicine | 2015 |
BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension
I Diebold, JK Hennigs, K Miyagawa, CG Li, NP Nickel, M Kaschwich, A Cao, L Wang, S Reddy, PI Chen, K Nakahira, MA Alcazar, RK Hopper, L Ji, BJ Feldman, M Rabinovitch |
Cell Metabolism | 2015 |
Elafin Reverses Pulmonary Hypertension via Caveolin-1–Dependent Bone Morphogenetic Protein Signaling
NP Nickel, E Spiekerkoetter, M Gu, CG Li, H Li, M Kaschwich, I Diebold, JK Hennigs, KY Kim, K Miyagawa, L Wang, A Cao, S Sa, X Jiang, RW Stockstill, MR Nicolls, RT Zamanian, RD Bland, M Rabinovitch |
American journal of respiratory and critical care medicine | 2015 |
Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system: Bone morphogenetic proteins and cardiovascular regulation
JY Luo, Y Zhang, L Wang, Y Huang |
The Journal of Physiology | 2015 |
PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21
DE Green, TC Murphy, BY Kang, CD Searles, CM Hart, J West |
PloS one | 2015 |
Activation of peroxisome proliferator-activated receptor γ ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
X Xie, G Wang, D Zhang, Y Zhang, Y Zhu, F Li, S Li, M Li |
Biomedical Reports | 2015 |
Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels
K Yang, W Lu, J Jia, J Zhang, M Zhao, S Wang, H Jiang, L Xu, J Wang |
American journal of physiology. Cell physiology | 2015 |
G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY
S Wang, KS Awad, JM Elinoff, EJ Dougherty, GA Ferreyra, JY Wang, R Cai, J Sun, A Ptasinska, RL Danner |
The Journal of biological chemistry | 2015 |
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit
T Bertero, KA Cottrill, Y Lu, CM Haeger, P Dieffenbach, S Annis, A Hale, B Bhat, V Kaimal, YY Zhang, BB Graham, R Kumar, R Saggar, R Saggar, WD Wallace, DJ Ross, SM Black, S Fratz, JR Fineman, SO Vargas, KJ Haley, AB Waxman, BN Chau, LE Fredenburgh, SY Chan |
Cell Reports | 2015 |
Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension
TV Kudryashova, DA Goncharov, A Pena, K Ihida-Stansbury, H DeLisser, SM Kawut, EA Goncharova |
Pulmonary circulation | 2015 |
Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells
KS Awad, JM Elinoff, S Wang, S Gairhe, GA Ferreyra, R Cai, J Sun, MA Solomon, RL Danner |
American journal of physiology. Lung cellular and molecular physiology | 2015 |
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Thomas Bertero, Yu Lu, Sofia Annis, Andrew Hale, Balkrishen Bhat, Rajan Saggar, Rajeev Saggar, W. Dean Wallace, David J. Ross, Sara O. Vargas, Brian B. Graham, Rahul Kumar, Stephen M. Black, Sohrab Fratz, Jeffrey R. Fineman, James D. West, Kathleen J. Haley, Aaron B. Waxman, B. Nelson Chau, Katherine A. Cottrill, Stephen Y. Chan |
Journal of Clinical Investigation | 2014 |
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
H Sawada, T Saito, NP Nickel, TP Alastalo, JP Glotzbach, R Chan, L Haghighat, G Fuchs, M Januszyk, A Cao, YJ Lai, VJ Perez, YM Kim, L Wang, PI Chen, E Spiekerkoetter, Y Mitani, GC Gurtner, P Sarnow, M Rabinovitch |
Journal of Experimental Medicine | 2014 |
Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension
M Rabinovitch, C Guignabert, M Humbert, MR Nicolls |
Circulation research | 2014 |
Pulmonary Arterial Hypertension and Insulin Resistance
DB Bradley |
Journal of molecular and genetic medicine : an international journal of biomedical research | 2014 |
Peripheral Blood Signature of Vasodilator-Responsive Pulmonary Arterial Hypertension
AR Hemnes, AW Trammell, SL Archer, S Rich, C Yu, H Nian, N Penner, M Funke, L Wheeler, IM Robbins, ED Austin, JH Newman, J West |
Circulation | 2014 |
Rosiglitazone Attenuated Endothelin-1-Induced Vasoconstriction of Pulmonary Arteries in the Rat Model of Pulmonary Arterial Hypertension via Differential Regulation of ET-1 Receptors
Y Liu, XY Tian, Y Huang, N Wang |
PPAR Research | 2014 |
Impact of diabetes on survival and right ventricular compensation in pulmonary arterial hypertension
L Benson, EL Brittain, ME Pugh, ED Austin, K Fox, L Wheeler, IM Robbins, AR Hemnes |
Pulmonary circulation | 2014 |
Targeting the Wnt signaling pathways in pulmonary arterial hypertension
VJ Perez, K Yuan, TP Alastalo, E Spiekerkoetter, M Rabinovitch |
Drug Discovery Today | 2014 |
The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up
SH Vitali, G Hansmann, C Rose, A Fernandez-Gonzalez, A Scheid, SA Mitsialis, S Kourembanas |
Pulmonary circulation | 2014 |
The MicroRNA-130/301 Family Controls Vasoconstriction in Pulmonary Hypertension
T Bertero, K Cottrill, A Krauszman, Y Lu, S Annis, A Hale, B Bhat, AB Waxman, BN Chau, WM Kuebler, SY Chan |
The Journal of biological chemistry | 2014 |
FK506 Activates BMPR2 Signaling, Rescues Endothelial Dysfunction, Reverses Pulmonary Hypertension
Edda Spiekerkoetter, Xuefei Tian, Jie Cai, Rachel Hopper, Deepti Sudheendra, Caiyun Grace Li, Nesrine El-Bizri, Hirofumi Sawada, Roxanna Haghighat, Roshelle Chan, Leila Haghighat, Vinicio de Jesus Perez, Lingli Wang, Sushma Reddy, Mingming Zhao, Daniel Bernstein, David Solow-Cordero, Philip A. Beachy, Thomas Wandless, Peter Ten Dijke, Marlene Rabinovitch |
Journal of Clinical Investigation | 2013 |
mTORC2 Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation and Survival in Pulmonary Arterial Hypertension
DA Goncharov, TV Kudryashova, H Ziai, K Ihida-Stansbury, H Delisser, VP Krymskaya, RM Tuder, SM Kawut, EA Goncharova |
Circulation | 2013 |
A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension
R Schwappacher, A Kilic, B Kojonazarov, M Lang, T Diep, S Zhuang, T Gawlowski, RT Schermuly, A Pfeifer, GR Boss, RB Pilz |
The Journal of biological chemistry | 2013 |
Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension
NW Morrell, SL Archer, A Defelice, S Evans, M Fiszman, T Martin, M Saulnier, M Rabinovitch, R Schermuly, D Stewart, H Truebel, G Walker, KR Stenmark |
Pulmonary circulation | 2013 |
Critical Role for the Advanced Glycation End‐Products Receptor in Pulmonary Arterial Hypertension Etiology
J Meloche, A Courchesne, M Barrier, S Carter, M Bisserier, R Paulin, JF LauzonJoset, S BreuilsBonnet, È Tremblay, S Biardel, C Racine, C Courture, P Bonnet, SM Majka, Y Deshaies, F Picard, S Provencher, S Bonnet |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2013 |
Signal transduction in the development of pulmonary arterial hypertension
S Malenfant, AS Neyron, R Paulin, F Potus, J Meloche, S Provencher, S Bonnet |
Pulmonary circulation | 2013 |
Hypoxia downregulates PPARγ via an ERK1/2–NF-κB–Nox4-dependent mechanism in human pulmonary artery smooth muscle cells
X Lu, KM Bijli, A Ramirez, TC Murphy, J Kleinhenz, CM Hart |
Free radical biology & medicine | 2013 |
Evidence for Right Ventricular Lipotoxicity in Heritable Pulmonary Arterial Hypertension
AR Hemnes, EL Brittain, AW Trammell, JP Fessel, ED Austin, N Penner, KB Maynard, L Gleaves, M Talati, T Absi, T Disalvo, J West |
American journal of respiratory and critical care medicine | 2013 |
Effects of propofol on renal ischemia/reperfusion injury in rats
S Yang, WP Chou, L Pei |
Experimental and therapeutic medicine | 2013 |
Hyperoxia Synergizes with Mutant Bone Morphogenic Protein Receptor 2 to Cause Metabolic Stress, Oxidant Injury, and Pulmonary Hypertension
JP Fessel, CR Flynn, LJ Robinson, NL Penner, S Gladson, CJ Kang, DH Wasserman, AR Hemnes, JD West |
American journal of respiratory cell and molecular biology | 2013 |
Oct-2 Transcription Factor Binding Activity and Expression Up-Regulation in Rat Cerebral Ischaemia is Associated with a Diminution of Neuronal Damage In Vitro
S Camós, C Gubern, M Sobrado, R Rodríguez, VG Romera, MÁ Moro, I Lizasoain, J Serena, J Mallolas, M Castellanos |
NeuroMolecular Medicine | 2013 |
Interdisciplinary networks for the treatment of childhood pulmonary vascular disease: what pulmonary hypertension doctors can learn from pediatric oncologists
G Hansmann |
Pulmonary circulation | 2013 |
Sildenafil Inhibits Hypoxia-Induced Transient Receptor Potential Canonical Protein Expression in Pulmonary Arterial Smooth Muscle via cGMP-PKG-PPARγ Axis
J Wang, K Yang, L Xu, Y Zhang, N Lai, H Jiang, Y Zhang, N Zhong, P Ran, W Lu |
American journal of respiratory cell and molecular biology | 2013 |
Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature
BY Kang, KK Park, DE Green, KM Bijli, CD Searles, RL Sutliff, CM Hart |
PloS one | 2013 |
Peroxisome proliferator activated receptor- -Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension
J Gien, N Tseng, G Seedorf, G Roe, SH Abman |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
Endothelin-1 decreases endothelial PPAR signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension
D Wolf, N Tseng, G Seedorf, G Roe, SH Abman, J Gien |
American journal of physiology. Lung cellular and molecular physiology | 2013 |
Downregulation of Bone Morphogenetic Protein Receptor Axis During HIV-1 and Cocaine-Mediated Pulmonary Smooth Muscle Hyperplasia: Implications for HIV-Related Pulmonary Arterial Hypertension
P Dalvi, A O'Brien-Ladner, NK Dhillon |
Arteriosclerosis, thrombosis, and vascular biology | 2013 |
SMAD1 Deficiency in Either Endothelial or Smooth Muscle Cells Can Predispose Mice to Pulmonary Hypertension
C Han, KH Hong, YH Kim, MJ Kim, C Song, MJ Kim, SJ Kim, MK Raizada, SP Oh |
Hypertension | 2013 |
Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism
V Karoor, M Oka, SJ Walchak, LB Hersh, YE Miller, EC Dempsey |
Hypertension | 2013 |
Hypoxia-Inducible Factor-1α in Pulmonary Artery Smooth Muscle Cells Lowers Vascular Tone by Decreasing Myosin Light Chain Phosphorylation
YM Kim, EA Barnes, CM Alvira, L Ying, S Reddy, DN Cornfield |
Circulation research | 2013 |
New horizons in pulmonary arterial hypertension therapies
Galiè N, Ghofrani AH |
European Respiratory Review | 2013 |
Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch |
Journal of Clinical Investigation | 2012 |
Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
AG Hameed, ND Arnold, J Chamberlain, JA Pickworth, C Paiva, S Dawson, S Cross, L Long, L Zhao, NW Morrell, DC Crossman, CM Newman, DG Kiely, SE Francis, A Lawrie |
Journal of Experimental Medicine | 2012 |
A process-based review of mouse models of pulmonary hypertension
M Das, J Fessel, H Tang, J West |
Pulmonary circulation | 2012 |
A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects
J Gomez-Arroyo, SJ Saleem, S Mizuno, AA Syed, HJ Bogaard, A Abbate, L Taraseviciene-Stewart, Y Sung, D Kraskauskas, D Farkas, DH Conrad, MR Nicolls, NF Voelkel |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization
C Iosef, TP Alastalo, Y Hou, C Chen, ES Adams, SC Lyu, DN Cornfield, CM Alvira |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation
SA Aljubran, R Cox, PT Parthasarathy, GK Ramanathan, V Rajanbabu, H Bao, SM Mohapatra, R Lockey, N Kolliputi |
PloS one | 2012 |
Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension
G Marsboom, C Wietholt, CR Haney, PT Toth, JJ Ryan, E Morrow, T Thenappan, P Bache-Wiig, L Piao, J Paul, CT Chen, SL Archer |
American journal of respiratory and critical care medicine | 2012 |
Today’s and tomorrow’s imaging and circulating biomarkers for pulmonary arterial hypertension
M Barrier, J Meloche, MH Jacob, A Courboulin, S Provencher, S Bonnet |
Cellular and Molecular Life Sciences | 2012 |
PPAR-γ Regulates Carnitine Homeostasis and Mitochondrial Function in a Lamb Model of Increased Pulmonary Blood Flow
S Sharma, X Sun, R Rafikov, S Kumar, Y Hou, PE Oishi, SA Datar, G Raff, JR Fineman, SM Black |
PloS one | 2012 |
Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis
J Wei, S Bhattacharyya, M Jain, J Varga |
The open rheumatology journal | 2012 |
BMP-2 Up-Regulates PTEN Expression and Induces Apoptosis of Pulmonary Artery Smooth Muscle Cells under Hypoxia
W Pi, X Guo, L Su, W Xu |
PloS one | 2012 |
Increased activation of NADPH oxidase 4 in the pulmonary vasculature in experimental diaphragmatic hernia
JH Gosemann, F Friedmacher, M Hunziker, L Alvarez, N Corcionivoschi, P Puri |
Pediatric Surgery International | 2012 |
Chronic inhibition of PPAR-γ signaling induces endothelial dysfunction in the juvenile lamb
S Sharma, J Barton, R Rafikov, S Aggarwal, HC Kuo, PE Oishi, SA Datar, JR Fineman, SM Black |
Pulmonary Pharmacology & Therapeutics | 2012 |
Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21WAF1
M Li, Y Liu, H Shi, Y Zhang, G Wang, J Xu, J Lu, D Zhang, X Xie, D Han, Y Wu, S Li |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2012 |
The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation
DE Green, TC Murphy, BY Kang, JM Kleinhenz, C Szyndralewiez, P Page, RL Sutliff, CM Hart |
American journal of respiratory cell and molecular biology | 2012 |
A potential role for insulin resistance in experimental pulmonary hypertension
J West, KD Niswender, JA Johnson, ME Pugh, L Gleaves, JP Fessel, AR Hemnes |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2012 |
Pulmonary hypertension: the science behind the disease spectrum
Wilkins MR |
European Respiratory Review | 2012 |
Dysfunctional BMP Signaling is Rescued via PPARγ-β-catenin-Mediated Regulation of Apelin in Humans and Mice
Tero-Pekka Alastalo, Molong Li, Vinicio de Jesus Perez, David Pham, Hirofumi Sawada, Jordon Wang, Minna Koskenvuo, Lingli Wang, Bruce Freeman, Howard Chang, Marlene Rabinovitch |
Journal of Clinical Investigation | 2011 |
Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension
G Hansmann, BD Plouffe, A Hatch, A Gise, H Sallmon, RT Zamanian, SK Murthy |
Journal of Molecular Medicine | 2011 |
Genetically manipulated mouse models of lung disease: potential and pitfalls
RM Baron, AJ Choi, CA Owen, AM Choi |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Mechanisms of disease: pulmonary arterial hypertension
RT Schermuly, HA Ghofrani, MR Wilkins, F Grimminger |
Nature Reviews Cardiology | 2011 |
Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension
MA Sparks, KK Parsons, J Stegbauer, SB Gurley, A Vivekanandan-Giri, CN Fortner, J Snouwaert, EW Raasch, RC Griffiths, TA Haystead, TH Le, S Pennathur, B Koller, TM Coffman |
Hypertension | 2011 |
New perspectives for the treatment of pulmonary hypertension
RS Baliga, RJ MacAllister, AJ Hobbs |
British Journal of Pharmacology | 2011 |
Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension
M Weng, DM Baron, KD Bloch, AD Luster, JJ Lee, BD Medoff |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions?
R Summer, K Walsh, BD Medoff |
Pulmonary circulation | 2011 |
Is peroxisome proliferator-activated receptor gamma (PPARγ) a therapeutic target for the treatment of pulmonary hypertension?
DE Green, RL Sutliff, CM Hart |
Pulmonary circulation | 2011 |
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner
A Lawrie, AG Hameed, J Chamberlain, N Arnold, A Kennerley, K Hopkinson, J Pickworth, DG Kiely, DC Crossman, SE Francis |
The American Journal of Pathology | 2011 |
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways
VA de Perez, Z Ali, TP Alastalo, F Ikeno, H Sawada, YJ Lai, T Kleisli, E Spiekerkoetter, X Qu, LH Rubinos, E Ashley, M Amieva, S Dedhar, M Rabinovitch |
The Journal of Cell Biology | 2011 |
HO-1 Induced by Cilostazol Protects Against TNF-α-associated Cytotoxicity via a PPAR-γ-dependent Pathway in Human Endothelial Cells
SY Park, JU Bae, KW Hong, CD Kim |
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology | 2011 |
Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension
I Morecroft, B Doyle, M Nilsen, W Kolch, K Mair, MR Maclean |
British Journal of Pharmacology | 2011 |
Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
Y Dempsie, M Nilsen, K White, KM Mair, L Loughlin, N Ambartsumian, M Rabinovitch, MR Maclean |
Respiratory Research | 2011 |
Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH
K White, L Loughlin, Z Maqbool, M Nilsen, J McClure, Y Dempsie, AH Baker, MR MacLean |
Physiological genomics | 2011 |
The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo
BY Kang, JM Kleinhenz, TC Murphy, CM Hart |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
K Gong, D Xing, P Li, B Aksut, N Ambalavanan, Q Yang, SE Nozell, S Oparil, YF Chen |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation
A Gangopahyay, M Oran, EM Bauer, JW Wertz, SA Comhair, SC Erzurum, PM Bauer |
The Journal of biological chemistry | 2011 |
Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease
S Fratz, JR Fineman, A Görlach, S Sharma, P Oishi, C Schreiber, T Kietzmann, I Adatia, J Hess, SM Black |
Circulation | 2011 |
cGMP and PKGI are required for vascular BMP signaling
Schwappacher R, Diep T, Boss G, Pilz R |
BMC pharmacology | 2011 |
Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension
L Tu, L Dewachter, B Gore, E Fadel, P Dartevelle, G Simonneau, M Humbert, S Eddahibi, C Guignabert |
American journal of respiratory cell and molecular biology | 2010 |
Adiponectin Decreases Pulmonary Arterial Remodeling in Murine Models of Pulmonary Hypertension
M Weng, MJ Raher, P Leyton, TP Combs, PE Scherer, KD Bloch, BD Medoff |
American journal of respiratory cell and molecular biology | 2010 |
Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies
SL Archer, EK Weir, MR Wilkins |
Circulation | 2010 |
Vascular smooth muscle cell PPARγ deletion promotes abdominal aortic aneurysms
M Hamblin, L Chang, H Zhang, K Yang, J Zhang, YE Chen |
Journal of Vascular Surgery | 2010 |
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
R Rajkumar, K Konishi, TJ Richards, DC Ishizawar, AC Wiechert, N Kaminski, F Ahmad |
American journal of physiology. Heart and circulatory physiology | 2010 |
PPARgamma as a potential therapeutic target in pulmonary hypertension
RL Sutliff, BY Kang, CM Hart |
Therapeutic advances in respiratory disease | 2010 |
Cellular and molecular aspects of vascular dysfunction in systemic sclerosis
M Trojanowska |
Nature Reviews Rheumatology | 2010 |
Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension
E Falcetti, SM Hall, PG Phillips, J Patel, NW Morrell, SG Haworth, LH Clapp |
American journal of respiratory and critical care medicine | 2010 |
Pulmonary hypertension in women
ME Pugh, AR Hemnes |
Expert Review of Cardiovascular Therapy | 2010 |
Peroxisome proliferator-activated receptor γ: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis
J Wei, S Bhattacharyya, J Varga |
Current Opinion in Rheumatology | 2010 |
Metabolic and Hormonal Derangements in Pulmonary Hypertension: From Mouse to Man
ME Pugh, AR Hemnes |
International journal of clinical practice. Supplement | 2010 |
PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB
X Lu, TC Murphy, MS Nanes, CM Hart |
AJP Lung Cellular and Molecular Physiology | 2010 |
Effect of Cocaine on Human Immunodeficiency Virus–Mediated Pulmonary Endothelial and Smooth Muscle Dysfunction
NK Dhillon, F Li, B Xue, O Tawfik, S Morgello, S Buch, AO Ladner |
American journal of respiratory cell and molecular biology | 2010 |
Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells
W Lu, P Ran, D Zhang, N Lai, N Zhong, J Wang |
AJP Cell Physiology | 2010 |
Update on Pulmonary Hypertension 2009
MT Gladwin, HA Ghofrani |
American journal of respiratory and critical care medicine | 2010 |
Persistent eNOS Activation Secondary to Caveolin-1 Deficiency Induces Pulmonary Hypertension through Protein Kinase G Nitration
You-Yang Zhao, Yidan D. Zhao*, Muhammad K. Mirza*, Julia H. Huang, Hari-Hara S.K. Potula, Steven M. Vogel, Viktor Brovkovych, Jason X-J Yuan, John Wharton, and Asrar B. Malik |
Journal of Clinical Investigation | 2009 |
Vascular smooth muscle cell-selective peroxisome proliferator-activated receptor-gamma deletion leads to hypotension
L Chang, L Villacorta, J Zhang, MT Garcia-Barrio, K Yang, M Hamblin, SE Whitesall, LG D'Alecy, YE Chen |
Circulation | 2009 |
Notch3 signaling promotes the development of pulmonary arterial hypertension
X Li, X Zhang, R Leathers, A Makino, C Huang, P Parsa, J Macias, JX Yuan, SW Jamieson, PA Thistlethwaite |
Nature Medicine | 2009 |
Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension
C Agard, M Rolli-Derkinderen, E Dumas-de-La-Roque, M Rio, C Sagan, JP Savineau, G Loirand, P Pacaud |
British Journal of Pharmacology | 2009 |
Hemodynamic Forces, Vascular Oxidative Stress, and Regulation of BMP-2/4 Expression
A Csiszar, S Lehoux, Z Ungvari |
Antioxidants & Redox Signaling | 2009 |
Prostaglandin E 2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation
A Lundequist, SN Nallamshetty, W Xing, C Feng, TM Laidlaw, S Uematsu, S Akira, JA Boyce |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4
E Spiekerkoetter, C Guignabert, V de Jesus Perez, TP Alastalo, JM Powers, L Wang, A Lawrie, N Ambartsumian, AM Schmidt, M Berryman, RH Ashley, M Rabinovitch |
Circulation research | 2009 |
The role of peroxisome proliferator-activated receptor γ in blood pressure regulation
M Hamblin, L Chang, J Zhang, YE Chen |
Current Hypertension Reports | 2009 |
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
C Guignabert, CM Alvira, TP Alastalo, H Sawada, G Hansmann, M Zhao, L Wang, N El-Bizri, M Rabinovitch |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model
RE Nisbet, JM Bland, DJ Kleinhenz, PO Mitchell, ER Walp, RL Sutliff, CM Hart |
American journal of respiratory cell and molecular biology | 2009 |
Molecular pathogenesis of pulmonary arterial hypertension
Marlene Rabinovitch |
Journal of Clinical Investigation | 2008 |
PPARγ and its ligands: therapeutic implications in cardiovascular disease
L Villacorta, FJ Schopfer, J Zhang, BA Freeman, YE Chen |
Clinical Science | 2008 |
Insulin resistance in pulmonary arterial hypertension
RT Zamanian, G Hansmann, S Snook, D Lilienfeld, KM Rappaport, GM Reaven, M Rabinovitch, RL Doyle |
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology | 2008 |