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Citations to this article

Antipsychotics in the treatment of autism
David J. Posey, … , Craig A. Erickson, Christopher J. McDougle
David J. Posey, … , Craig A. Erickson, Christopher J. McDougle
Published January 2, 2008
Citation Information: J Clin Invest. 2008;118(1):6-14. https://doi.org/10.1172/JCI32483.
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Science in Medicine Article has an altmetric score of 30

Antipsychotics in the treatment of autism

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Abstract

Atypical antipsychotics have become indispensable in the treatment of a variety of symptoms in autism. They are frequently used to treat irritability and associated behaviors including aggression and self injury. They may also be efficacious for hyperactivity and stereotyped behavior. This review presents the rationale for the use of this drug class in autism and reviews the most important studies published on this topic to date. Significant adverse effects, including weight gain and the possibility of tardive dyskinesia, are reviewed. Future research directions are discussed.

Authors

David J. Posey, Kimberly A. Stigler, Craig A. Erickson, Christopher J. McDougle

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009 Total
Citations: 1 9 6 6 3 3 2 2 2 3 4 4 3 3 5 2 58
Citation information
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Citations to this article (58)

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Management of antipsychotics in primary care: Insights from healthcare professionals and policy makers in the United Kingdom.
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The use of psychotropic medications in autistic individuals (21 years and younger) in Western Australia: A preliminary investigation.
Bulonza R, Watkins K, Parsons R, Sunderland B, Whitehouse A, Caccetta R
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Quetiapine and Valproic Acid-induced Central Hypothyroidism in a Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case Report.
Daramjav N, Takagi J, Iwayama H, Kanemoto K, Otake K
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Antipsychotic management in general practice: serial cross-sectional study (2011–2020)
Woodall A, Gampel A, Walker LE, Mair FS, Sheard S, Symon P, Buchan I
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Anti-inflammatory properties of commonly used psychiatric drugs
Patel S, Keating BA, Dale RC
Frontiers in neuroscience 2023
Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics
Maurer JJ, Choi A, An I, Sathi N, Chung S
Neurobiology of Sleep and Circadian Rhythms 2023
CYP2D6 Genotype and Pharmacovigilance Impact on Autism Spectrum Disorder: A Naturalistic Study with Extreme Phenotype Analysis
Ballester P, Espadas C, Almenara S, Barrachina J, Muriel J, Ramos E, Toral N, Belda C, Peiró AM
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Five‐year trend of antipsychotic prescription practices in a district Hospital in Ghana: A retrospective study
Daliri DB, Afaya A, Laari TT, Fredrick A, Ankamah AG, Annan S, Abagye N
2023
Cardiometabolic Effects of Antipsychotics in Challenging Behavior and Neuropsychiatric Symptoms in Patients With Intellectual Disability
Takano T
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The Frequency of CYP2D6 and CYP3A4/5 Genotypes and The Impact of Their Allele Translation and Phenoconversion-Predicted Enzyme Activity on Risperidone Pharmacokinetics in Saudi Children with Autism.
Shilbayeh SAR, Adeen IS, Alhazmi AS, Ibrahim SF, Al Enazi FAR, Ghanem EH, Binduraihem AM
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Effectiveness and Adverse Effects of Risperidone in Children with Autism Spectrum Disorder in a Naturalistic Clinical Setting at a University Hospital in Oman
Al-Huseini S, Al-Barhoumi A, Al-Balushi M, Al-Hosni A, Al-Mahrouqi T, Al-Mahrizi B, Jaju S, Mirza H
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Clinical Discordance in Monozygotic Twins With Autism Spectrum Disorder
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Atypical antipsychotics for autism spectrum disorder: a network meta‐analysis
Meza N, Rees R, Escobar Liquitay CM, Franco JV, Sguassero Y, Williams K, Pringsheim T, Rojas V, Madrid E
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Chieh AY, Bryant BM, Kim JW, Li L
Research in Autism Spectrum Disorders 2021
Acceptability, equity, and feasibility of using antipsychotics in children and adolescents with autism spectrum disorder: a systematic review
GL DAlò, FD Crescenzo, L Amato, F Cruciani, M Davoli, F Fulceri, S Minozzi, Z Mitrova, GP Morgano, F Nardocci, R Saulle, HJ Schünemann, ML Scattoni
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Q Ding, F Sethna, XT Wu, Z Miao, P Chen, Y Zhang, H Xiao, W Feng, Y Feng, X Li, H Wang
2020
Sulforaphane treatment for autism spectrum disorder: A systematic review
McGuinness G, Kim Y
EXCLI journal 2020
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H Bae, JY Park, YS Yang
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Characteristics of Children Prescribed Antipsychotics: Analysis of Routinely Collected Data
S Brophy, J Kennedy, F Fernandez-Gutierrez, A John, R Potter, C Linehan, M Kerr
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LK Wink, R Adams, PS Horn, CR Tessier, AP Bantel, M Hong, RC Shaffer, EV Pedapati, CA Erickson
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Pharmacogenomic testing: aiding in the management of psychotropic therapy for adolescents with autism spectrum disorders
S Bose-Brill, J Xing, D Barnette, C Hanks
Pharmacogenomics and Personalized Medicine 2017
Brief Report: Metformin for Antipsychotic-Induced Weight Gain in Youth with Autism Spectrum Disorder.
Wink LK, Adams R, Pedapati EV, Dominick KC, Fox E, Buck C, Erickson CA
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Cochrane Database of Systematic Reviews: Reviews
LE Hirsch, T Pringsheim, T Pringsheim
Cochrane Database of Systematic Reviews: Reviews 2016
Prescription trends in children with pervasive developmental disorders (PDD): A claims data-based study in Japan
M Satoh, T Obara, H Nishigori, N Ooba, Y Morikawa, M Ishikuro, H Metoki, M Kikuya, N Mano
World Journal of Pediatrics 2016
Defining the hidden evidence in autism research. Forty per cent of rigorously designed clinical trials remain unpublished ‐ a cross‐sectional analysis
Mechler K, Hoffmann GF, Dittmann RW, Ries M
International Journal of Methods in Psychiatric Research 2016
Obesity Prevention for Children with Developmental Disabilities
A Must, C Curtin, K Hubbard, L Sikich, J Bedford, L Bandini
Current Obesity Reports 2014
Obesity in Children with Autism Spectrum Disorder:
C Curtin, M Jojic, LG Bandini
Harvard Review of Psychiatry 2014
An aberrant precision account of autism
RP Lawson, G Rees, KJ Friston
Frontiers in human neuroscience 2014
Multidisciplinary Assessment and Treatment of Self-Injurious Behavior in Autism Spectrum Disorder and Intellectual Disability: Integration of Psychological and Biological Theory and Approach
NF Minshawi, S Hurwitz, D Morriss, CJ McDougle
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LK Koegel, AM Krasno, H Taras, RL Koegel, W Frea
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An Open-Label Extension Study of the Safety and Efficacy of Risperidone in Children and Adolescents with Autistic Disorder
JM Kent, D Hough, J Singh, K Karcher, G Pandina
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Focal brain inflammation and autism
TC Theoharides, S Asadi, AB Patel
Journal of Neuroinflammation 2013
Psychopharmacological prescriptions for people with autism spectrum disorder (ASD): a multinational study.
Hsia Y, Wong AY, Murphy DG, Simonoff E, Buitelaar JK, Wong IC
Psychopharmacology 2013
Adenosine and autism: A spectrum of opportunities
SA Masino, M Kawamura, JL Cote, RB Williams, DN Ruskin
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Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
GS Dichter, CA Damiano, JA Allen
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Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
A Sato, S Kasai, T Kobayashi, Y Takamatsu, O Hino, K Ikeda, M Mizuguchi
Nature Communications 2012
Long-Term Aripiprazole in Youth With Developmental Disabilities Including Autism
JA Hellings, D Boehm, HW Yeh, MG Butler, SR Schroeder
Journal of Mental Health Research in Intellectual Disabilities 2011
Aripiprazole: a review of its use in the treatment of irritability associated with autistic disorder patients aged 6-17
P Douglas-Hall, S Curran, V Bird, D Taylor
Journal of Central Nervous System Disease 2011
Relaxation response-based yoga improves functioning in young children with autism: a pilot study
LE Rosenblatt, S Gorantla, JA Torres, RS Yarmush, S Rao, ER Park, JW Denninger, H Benson, GL Fricchione, B Bernstein, JB Levine
The Journal of Alternative and Complementary Medicine 2011
Risperidone Administered During Asymptomatic Period of Adolescence Prevents the Emergence of Brain Structural Pathology and Behavioral Abnormalities in an Animal Model of Schizophrenia
Y Piontkewitz, M Arad, I Weiner
Schizophrenia Bulletin 2010
Micronutrients Versus Standard Medication Management in Autism: A Naturalistic Case–Control Study
L Mehl-Madrona, B Leung, C Kennedy, S Paul, BJ Kaplan
Journal of Child and Adolescent Psychopharmacology 2010
Emerging drugs for the treatment of symptoms associated with autism spectrum disorders
LK Wink, MH Plawecki, CA Erickson, KA Stigler, CJ McDougle
Expert Opinion on Emerging Drugs 2010
Aripiprazole for irritability associated with autistic disorder in children and adolescents aged 6–17 years
Blankenship K, Erickson CA, Stigler KA, Posey DJ, McDougle CJ
Pediatric Health 2010
Psychotropic medication use among children with autism spectrum disorders enrolled in a national registry, 2007-2008.
Rosenberg RE, Mandell DS, Farmer JE, Law JK, Marvin AR, Law PA
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
A Longitudinal Investigation of Psychotropic and Non-Psychotropic Medication Use Among Adolescents and Adults with Autism Spectrum Disorders
AJ Esbensen, JS Greenberg, MM Seltzer, MG Aman
Journal of Autism and Developmental Disorders 2009

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