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Citations to this article

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
Jeremy R. Graff, … , Julia H. Carter, Eric G. Marcusson
Jeremy R. Graff, … , Julia H. Carter, Eric G. Marcusson
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2638-2648. https://doi.org/10.1172/JCI32044.
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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

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Abstract

Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of growth factors important in malignancy (e.g., VEGF, cyclin D1) and is thereby an attractive anticancer therapeutic target. Yet to date, no eIF4E-specific therapy has been developed. Herein we report development of eIF4E-specific antisense oligonucleotides (ASOs) designed to have the necessary tissue stability and nuclease resistance required for systemic anticancer therapy. In mammalian cultured cells, these ASOs specifically targeted the eIF4E mRNA for destruction, repressing expression of eIF4E-regulated proteins (e.g., VEGF, cyclin D1, survivin, c-myc, Bcl-2), inducing apoptosis, and preventing endothelial cells from forming vessel-like structures. Most importantly, intravenous ASO administration selectively and significantly reduced eIF4E expression in human tumor xenografts, significantly suppressing tumor growth. Because these ASOs also target murine eIF4E, we assessed the impact of eIF4E reduction in normal tissues. Despite reducing eIF4E levels by 80% in mouse liver, eIF4E-specific ASO administration did not affect body weight, organ weight, or liver transaminase levels, thereby providing the first in vivo evidence that cancers may be more susceptible to eIF4E inhibition than normal tissues. These data have prompted eIF4E-specific ASO clinical trials for the treatment of human cancers.

Authors

Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent, Rebecca L. Lynch, David Monteith, Spring N. Weir, Phil Schwier, Andrew Capen, Robin L. Goode, Michele S. Dowless, Yuefeng Chen, Hong Zhang, Sean Sissons, Karen Cox, Ann M. McNulty, Stephen H. Parsons, Tao Wang, Lillian Sams, Sandaruwan Geeganage, Larry E. Douglass, Blake Lee Neubauer, Nicholas M. Dean, Kerry Blanchard, Jianyong Shou, Louis F. Stancato, Julia H. Carter, Eric G. Marcusson

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Citations to this article (203)

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The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled
MJ Osborne, KL Borden
Immunological Reviews 2014
The Role of Translational Regulation in Survival after Radiation Damage; an Opportunity for Proteomics Analysis
S Stickel, N Gomes, T Su
Proteomes 2014
New insights into 4E-BP1-regulated translation in cancer progression and metastasis
Wang J, Ye Q, She QB
Cancer Cell & Microenvironment 2014
Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail.
Cai W, Ye Q, She QB
Oncotarget 2014
First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines
Ramalingam S, Gediya L, Kwegyir-Afful AK, Ramamurthy VP, Purushottamachar P, Mbatia H, Njar VC
Oncotarget 2014
The Oncogene eIF4E: Using Biochemical Insights to Target Cancer
M Carroll, KL Borden
Journal of Interferon & Cytokine Research 2013
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate
L Volpon, MJ Osborne, H Zahreddine, AA Romeo, KL Borden
Biochemical and Biophysical Research Communications 2013
Hepatic RNA interference: delivery by synthetic vectors
MT Haynes, L Huang
Drug Delivery and Translational Research 2013
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors
JK Altman, A Szilard, BW Konicek, PW Iversen, B Kroczynska, H Glaser, A Sassano, E Vakana, JR Graff, LC Platanias
Blood 2013
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
M Pourdehnad, ML Truitt, IN Siddiqi, GS Ducker, KM Shokat, D Ruggero
Proceedings of the National Academy of Sciences 2013
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
MJ Gerdes, CJ Sevinsky, A Sood, S Adak, MO Bello, A Bordwell, A Can, A Corwin, S Dinn, RJ Filkins, D Hollman, V Kamath, S Kaanumalle, K Kenny, M Larsen, M Lazare, Q Li, C Lowes, CC McCulloch, E McDonough, MC Montalto, Z Pang, J Rittscher, A Santamaria-Pang, BD Sarachan, ML Seel, A Seppo, K Shaikh, Y Sui, J Zhang, F Ginty
Proceedings of the National Academy of Sciences 2013
Resistance to EGFR-TKI Can Be Mediated through Multiple Signaling Pathways Converging upon Cap-Dependent Translation in EGFR-Wild Type NSCLC:
MR Patel, J Jay-Dixon, AA Sadiq, BA Jacobson, RA Kratzke
Journal of Thoracic Oncology 2013
Translational control of the fibroblast-extracellular matrix association: An application to pulmonary fibrosis
RS Nho, V Polunovsky
Translation 2013
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia
F Hariri, M Arguello, L Volpon, B Culjkovic-Kraljacic, TH Nielsen, J Hiscott, KK Mann, KL Borden
Leukemia 2013
Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics
N AlQurashi, S Hashimi, M Wei
International journal of molecular sciences 2013
Axonal cap-dependent translation regulates presynaptic p35: Translational Control of Bouton Function
K Hsiao, O Bozdagi, DL Benson
Developmental Neurobiology 2013
Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide
BA Jacobson, SC Thumma, J Jay-Dixon, MR Patel, KD Kroening, MG Kratzke, RG Etchison, BW Konicek, JR Graff, RA Kratzke
PloS one 2013
Enzymatic synthesis of RNAs capped with nucleotide analogues reveals the molecular basis for substrate selectivity of RNA capping enzyme: impacts on RNA metabolism
M Issur, I Bougie, S Despins, M Bisaillon
PloS one 2013
Requirement for the eIF4E binding proteins for the synergistic down-regulation of protein synthesis by hypertonic conditions and mTOR inhibition
MJ Clemens, A Elia, SJ Morley
PloS one 2013
Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization
H Wang, Y Ru, M Sanchez-Carbayo, X Wang, JS Kieft, D Theodorescu
Clinical cancer research 2013
Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation
MJ Fournier, L Coudert, S Mellaoui, P Adjibade, C Gareau, MF Côté, N Sonenberg, RC Gaudreault, R Mazroui
Molecular and cellular biology 2013
Targeted Delivery of Antisense Oligonucleotides by Chemically Self-Assembled Nanostructures
A Gangar, A Fegan, SC Kumarapperuma, P Huynh, A Benyumov, CR Wagner
Molecular Pharmaceutics 2013
Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced eIF4E Proteasomal Degradation
S Li, Y Jia, B Jacobson, J McCauley, R Kratzke, PB Bitterman, CR Wagner
Molecular Pharmaceutics 2013
Small-molecule targeting of translation initiation for cancer therapy
Aktas BH, Qiao Y, Ozdelen E, Schubert R, Sevinc S, Harbinski F, Grubissich L, Singer S, Halperin JA
Oncotarget 2013
Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
Yuanyuan Ruan, Linlin Sun, Yuqing Hao, Lijing Wang, Jiejie XU, Wen Zhang, Jianhui Xie, Liang Guo, Lei Zhou, Xiaojing Yun, Hongguang Zhu, Aiguo Shen, Jianxin Gu
Journal of Clinical Investigation 2012
Tumor suppression by small molecule inhibitors of translation initiation
L Chen, BH Aktas, Y Wang, X He, R Sahoo, N Zhang, S Denoyelle, E Kabha, H Yang, RY Freedman, JG Supko, M Chorev, G Wagner, JA Halperin
Oncotarget 2012
eIF4F suppression in breast cancer affects maintenance and progression
Z Nasr, F Robert, JA Porco, WJ Muller, J Pelletier
Oncogene 2012
The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction
G Descamps, P Gomez-Bougie, J Tamburini, A Green, D Bouscary, S Maïga, P Moreau, SL Gouill, C Pellat-Deceunynck, M Amiot
British Journal of Cancer 2012
Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E
Y Ge, R Cheng, Y Zhou, J Shen, L Peng, X Xu, Q Dai, P Liu, H Wang, X Ma, J Jia, Z Chen
Molecular and Cellular Biochemistry 2012
Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis
CJ Lin, Z Nasr, PK Premsrirut, JA Porco, Y Hippo, SW Lowe, J Pelletier
Cell Reports 2012
Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma
XL Wang, HP Cai, JH Ge, XF Su
World journal of gastroenterology : WJG 2012
Versatility of RNA-Binding Proteins in Cancer
L Wurth
Comparative and Functional Genomics 2012
Translational Homeostasis via the mRNA Cap-Binding Protein, eIF4E
A Yanagiya, E Suyama, H Adachi, YV Svitkin, P Aza-Blanc, H Imataka, S Mikami, Y Martineau, ZA Ronai, N Sonenberg
Molecular Cell 2012
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs
M Badura, S Braunstein, J Zavadil, RJ Schneider
Proceedings of the National Academy of Sciences 2012
Autism-related deficits via dysregulated eIF4E-dependent translational control
CG Gkogkas, A Khoutorsky, I Ran, E Rampakakis, T Nevarko, DB Weatherill, C Vasuta, S Yee, M Truitt, P Dallaire, F Major, P Lasko, D Ruggero, K Nader, JC Lacaille, N Sonenberg
Nature 2012
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer
Y Li, S Fan, J Koo, P Yue, ZG Chen, TK Owonikoko, SS Ramalingam, FR Khuri, SY Sun
Cancer biology & therapy 2012
The Development of Novel Therapies for the Treatment of Acute Myeloid Leukemia (AML)
S Assouline, E Cocolakis, KL Borden
Cancers 2012
Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer
F Meric-Bernstam, H Chen, A Akcakanat, KA Do, A Lluch, BT Hennessy, GN Hortobagyi, GB Mills, AM Gonzalez-Angulo
Breast Cancer Research 2012
The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G
C la Parra, E Otero-Franqui, M Martinez-Montemayor, S Dharmawardhane
The Journal of biological chemistry 2012
Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects
W Zhou, ST Quah, CS Verma, Y Liu, DP Lane, CJ Brown
PloS one 2012
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
LM Lindqvist, I Vikström, JM Chambers, K McArthur, MA Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DC Huang
Cell Death and Disease 2012
Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation
PB Bitterman, VA Polunovsky
Molecular cancer therapeutics 2012
Emerging therapeutics targeting mRNA translation
A Malina, JR Mills, J Pelletier
Cold Spring Harbor perspectives in biology 2012
Post-transcriptional regulation in cancer progression
M Jewer, SD Findlay, LM Postovit
Journal of Cell Communication and Signaling 2012
Translational Control in Cancer Etiology
D Ruggero
Cold Spring Harbor perspectives in biology 2012
Translation Initiation Factor eIF4E Is a Target for Tumor Cell Radiosensitization
TJ Hayman, ES Williams, M Jamal, UT Shankavaram, K Camphausen, PJ Tofilon
Cancer research 2012
Cap-Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target: CAP-DEPENDENT TRANSLATION INITIATION EIF4E INHIBITION
Y Jia, V Polunovsky, PB Bitterman, CR Wagner
Medicinal Research Reviews 2012
The biological and therapeutic relevance of mRNA translation in cancer
SP Blagden, AE Willis
Nature Reviews Clinical Oncology 2011
Oncogenic AKTivation of translation as a therapeutic target
AC Hsieh, ML Truitt, D Ruggero
British Journal of Cancer 2011
IMiD immunomodulatory compounds block C/EBPβ translation through eIF4E down-regulation resulting in inhibition of MM
S Li, R Pal, SA Monaghan, P Schafer, H Ouyang, M Mapara, DL Galson, S Lentzsch
Blood 2011
Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation
R Kratzke
International journal of oncology 2011
A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer
DS Hong, R Kurzrock, Y Oh, J Wheler, A Naing, L Brail, S Callies, V Andre, SK Kadam, A Nasir, TR Holzer, F Meric-Bernstam, M Fishman, G Simon
Clinical cancer research 2011
Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication
R Cencic, M Desforges, DR Hall, D Kozakov, Y Du, J Min, R Dingledine, H Fu, S Vajda, PJ Talbot, J Pelletier
Journal of virology 2011
Translational Regulation in Nutrigenomics
B Liu, SB Qian
Advances in nutrition (Bethesda, Md.) 2011
Ribavirin Treatment Effects on Breast Cancers Overexpressing eIF4E, a Biomarker with Prognostic Specificity for Luminal B-Type Breast Cancer
F Pettersson, C Yau, MC Dobocan, B Culjkovic-Kraljacic, H Retrouvay, R Puckett, LM Flores, IE Krop, C Rousseau, E Cocolakis, KL Borden, CC Benz, WH Miller
Clinical cancer research 2011
Targeting Translation Dependence in Cancer
Malina A, Cencic R, Pelletier J
Oncotarget 2011
Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence.
Chao SK, Horwitz SB, McDaid HM
Oncotarget 2011
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
R Cencic, DR Hall, F Robert, Y Du, J Min, L Li, M Qui, I Lewis, S Kurtkaya, R Dingledine, H Fu, D Kozakov, S Vajda, J Pelletier
Proceedings of the National Academy of Sciences 2010
Direct inhibition of eIF4E reduced cell growth in endometrial adenocarcinoma
CH Choi, JS Lee, SR Kim, YY Lee, CJ Kim, JW Lee, TJ Kim, JH Lee, BG Kim, DS Bae
Journal of Cancer Research and Clinical Oncology 2010
Postnatal Deamidation of 4E-BP2 in Brain Enhances Its Association with Raptor and Alters Kinetics of Excitatory Synaptic Transmission
M Bidinosti, I Ran, MR Sanchez-Carbente, Y Martineau, AC Gingras, C Gkogkas, B Raught, CR Bramham, WS Sossin, M Costa-Mattioli, L DesGroseillers, JC Lacaille, N Sonenberg
Molecular Cell 2010
Targeting the translational machinery as a novel treatment strategy for hematologic malignancies
PR Hagner, A Schneider, RB Gartenhaus
Blood 2010
Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells
F Zhou, M Yan, G Guo, F Wang, H Qiu, F Zheng, Y Zhang, Q Liu, X Zhu, L Xia
Medical Oncology 2010
Individual and combined soy isoflavones exert differential effects on metastatic cancer progression
MM Martínez-Montemayor, E Otero-Franqui, J Martinez, AD la Mota-Peynado, LA Cubano, S Dharmawardhane
Clinical & Experimental Metastasis 2010
Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?
KL Borden, B Culjkovic-Kraljacic
Leukemia & Lymphoma 2010
Noncytotoxic inhibition of viral infection through eIF4F-independent suppression of translation by 4EGi-1
R McMahon, I Zaborowska, D Walsh
Journal of virology 2010
Inhibition of translation by cytotrienin A--a member of the ansamycin family
L Lindqvist, F Robert, W Merrick, H Kakeya, C Fraser, H Osada, J Pelletier
RNA (New York, N.Y.) 2010
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically
X Xu, J Vatsyayan, C Gao, CJ Bakkenist, J Hu
The Journal of biological chemistry 2010
Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells
N Chakravarti, H Kadara, DJ Yoon, JW Shay, JN Myers, D Lotan, N Sonenberg, R Lotan
Cancer prevention research (Philadelphia, Pa.) 2010
Expression of human eukaryotic initiation factor 3f oscillates with cell cycle in A549 cells and is essential for cell viability
AE Higareda-Mendoza, MA Pardo-Galván
Cell division 2010
[Expression and its clinical significance of eIF4E in non-small cell lung cancer]
Bo ZHANG, Chengchu ZHU, Baofu CHEN, Xia ZHANG, Minhua YE, Aifen LIN
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2010
Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer: Fig. 1
AC Hsieh, D Ruggero
Clinical cancer research 2010
The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation
Fan S, Li Y, Yue P, Khuri FR, Sun SY
Neoplasia (New York, N.Y.) 2010
Sumoylation of eIF4E activates mRNA translation
Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J
EMBO reports 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer
B Culjkovic, KL Borden
Journal of Oncology 2009
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
N Sonenberg, AG Hinnebusch
Cell 2009
Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma
BA Jacobson, A De, MG Kratzke, MR Patel, J Jay-Dixon, BA Whitson, AA Sadiq, PB Bitterman, VA Polunovsky, RA Kratzke
British Journal of Cancer 2009
Targeting the mTOR signaling network for cancer therapy
F Meric-Bernstam, AM Gonzalez-Angulo
Journal of Clinical Oncology 2009
Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation
NK Mukhopadhyay, J Kim, B Cinar, A Ramachandran, MH Hager, DD Vizio, RM Adam, MA Rubin, P Raychaudhuri, AD Benedetti, MR Freeman
Cancer research 2009
Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells
R Cencic, M Carrier, A Trnkus, JA Porco, M Minden, J Pelletier
Leukemia Research 2009
Nontoxic Chemical Interdiction of the Epithelial-to-Mesenchymal Transition by Targeting Cap-Dependent Translation
B Ghosh, AO Benyumov, P Ghosh, Y Jia, S Avdulov, PS Dahlberg, M Peterson, K Smith, VA Polunovsky, PB Bitterman, CR Wagner
ACS chemical biology 2009
mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition
PT Bhaskar, V Nogueira, KC Patra, SM Jeon, Y Park, RB Robey, N Hay
Molecular and cellular biology 2009
Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.
Fan S, Ramalingam SS, Kauh J, Xu Z, Khuri FR, Sun SY
Cancer biology & therapy 2009
Therapeutic Suppression of Translation Initiation Modulates Chemosensitivity
Marie-Eve Bordeleau, Francis Robert, Baudouin Gerard, Lisa Lindqvist, Samuel M.H. Chen, Hans-Guido Wendel, Brigitte Brem, Harald Greger, Scott W. Lowe, John A. Porco, Jr, and Jerry Pelletier
Journal of Clinical Investigation 2008
Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs
L Rong, M Livingstone, R Sukarieh, E Petroulakis, AC Gingras, K Crosby, B Smith, RD Polakiewicz, J Pelletier, MA Ferraiuolo, N Sonenberg
RNA (New York, N.Y.) 2008
Ribavirin targets eIF4E dependent Akt survival signaling
K Tan, B Culjkovic, A Amri, KL Borden
Biochemical and Biophysical Research Communications 2008
eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling
A Soni, A Akcakanat, G Singh, D Luyimbazi, Y Zheng, D Kim, A Gonzalez-Angulo, F Meric-Bernstam
Molecular cancer therapeutics 2008
Localized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions*S⃞
HC Stuart, Z Jia, A Messenberg, B Joshi, TM Underhill, H Moukhles, IR Nabi
The Journal of biological chemistry 2008
Increased Susceptibility of Breast Cancer Cells to Stress Mediated Inhibition of Protein Synthesis
S Pervin, AH Tran, S Zekavati, JM Fukuto, R Singh, G Chaudhuri
Cancer research 2008
Metastasis Research Society–American Association for Cancer Research Joint Conference on Metastasis
DR Welch, CR Cooper, DR Hurst, CC Lynch, MD Martin, KS Vaidya, MN VanSaun, AM Mastro
Cancer research 2008
Reduced Eukaryotic Initiation Factor 2Bε-Subunit Expression Suppresses the Transformed Phenotype of Cells Overexpressing the Protein
JW Gallagher, N Kubica, SR Kimball, LS Jefferson
Cancer research 2008
Taking aim at translation for tumor therapy
Bryan C. Barnhart, M. Celeste Simon
Journal of Clinical Investigation 2007

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