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Yin and yang interplay of IFN-γ in inflammation and autoimmune disease
Jingwu Zhang
Jingwu Zhang
Published April 2, 2007
Citation Information: J Clin Invest. 2007;117(4):871-873. https://doi.org/10.1172/JCI31860.
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Yin and yang interplay of IFN-γ in inflammation and autoimmune disease

Abstract

IFN-γ has long been recognized as a signature proinflammatory cytokine that plays a central role in inflammation and autoimmune disease. There is now emerging evidence indicating that IFN-γ possesses unexpected properties as a master regulator of immune responses and inflammation. In this issue of the JCI, Guillonneau et al. show that indefinite allograft survival induced by CD40Ig treatment is mediated by CD8+CD45RClow T cells through the production of IFN-γ (see the related article beginning on page 1096), supporting the emerging view that IFN-γ is critical in the self-regulation of inflammation. These contradictory roles of IFN-γ, perhaps best understood by the principle of yin and yang, represent one of nature’s paradoxes, whereby the same cytokine functions as an inducer as well as a regulator for inflammation. Understanding this complex process of IFN-γ signaling is essential, as it has therapeutic implications.

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Jingwu Zhang

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