Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis
Joel D. Ernst, … , Giraldina Trevejo-Nuñez, Niaz Banaiee
Joel D. Ernst, … , Giraldina Trevejo-Nuñez, Niaz Banaiee
Published July 2, 2007
Citation Information: J Clin Invest. 2007;117(7):1738-1745. https://doi.org/10.1172/JCI31810.
View: Text | PDF
Science in Medicine Article has an altmetric score of 5

Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis

  • Text
  • PDF
Abstract

Tuberculosis kills nearly 2 million people annually, and current approaches to tuberculosis control are expensive, have limited efficacy, and are vulnerable to being overcome by extensively drug-resistant strains of Mycobacterium tuberculosis. Determination of the genome sequence of M. tuberculosis has revolutionized tuberculosis research, contributed to major advances in the understanding of the evolution and pathogenesis of M. tuberculosis, and facilitated development of new diagnostic tests with increased specificity for tuberculosis. In this review, we describe some of the major progress in tuberculosis research that has resulted from knowledge of the genome sequence and note some of the problems that remain unsolved.

Authors

Joel D. Ernst, Giraldina Trevejo-Nuñez, Niaz Banaiee

×

Figure 2

The RD1 locus and components of the ESX-1 secretion system.

Options: View larger image (or click on image) Download as PowerPoint
The RD1 locus and components of the ESX-1 secretion system.
ESAT-6 and C...
ESAT-6 and CFP-10 dimer secretion (A) by M. tuberculosis depends on other genes in the RD1 locus (B). The product of Rv3870 is a membrane protein that interacts directly with Rv3871, a predicted cytoplasmic protein. Based on homology to the SpoIIIE/FtsK family, Rv3870 and Rv3871 are thought to form a membrane-bound ATPase that provides energy for export of secretion substrates; the carboxyl terminus of CFP-10 interacts directly with the carboxyl terminus of Rv3871. Rv3877 encodes a protein with 12 membrane-spanning domains and is likely to form a secretion pore. Rv3876 is essential for secretion of CFP-10 and ESAT-6 dimers, but its role has not been determined. Secretion substrates encoded by genes outside the BCG RD1 locus include the product of Rv3616c (57), and additional genes essential for ESAT-6 secretion that are outside of the BCG RD1 include Rv3614c, Rv3615c, and Rv3616c (57, 60). The products of Rv3614c and Rv3882c have been found to directly interact (60).

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Posted by 2 X users
Referenced in 6 Wikipedia pages
168 readers on Mendeley
See more details